locus-tag	class	description
H0O22_00045	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H0O22_00055	COG0733	neurotransmitter:sodium symporter activity
H0O22_00065	COG0215	cysteine-tRNA ligase activity
H0O22_00070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0O22_00070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0O22_00090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0O22_00110	COG0335	large ribosomal subunit rRNA binding
H0O22_00120	COG0024	Methionine aminopeptidase
H0O22_00125	COG3000	fatty acid hydroxylase
H0O22_00125	COG0300	oxidoreductase activity
H0O22_00135	COG0857	belongs to the CobB CobQ family
H0O22_00150	COG1666	GTP binding
H0O22_00160	COG0405	Gamma-glutamyltransferase
H0O22_00165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H0O22_00175	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H0O22_00180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H0O22_00185	COG0277	FAD linked oxidase domain protein
H0O22_00190	COG0708	Exodeoxyribonuclease III
H0O22_00215	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
H0O22_00225	COG0735	belongs to the Fur family
H0O22_00240	COG0523	cobalamin synthesis protein
H0O22_00255	COG1121	(ABC) transporter
H0O22_00265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0O22_00280	COG0701	Predicted permease
H0O22_00295	COG0720	synthase
H0O22_00300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0O22_00300	COG0140	phosphoribosyl-ATP diphosphatase activity
H0O22_00305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0O22_00325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0O22_00330	COG3339	Conserved Protein
H0O22_00375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H0O22_00395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0O22_00400	COG2264	protein methyltransferase activity
H0O22_00415	COG2010	Cytochrome c
H0O22_00420	COG1234	tRNA 3'-trailer cleavage
H0O22_00425	COG2247	cell wall binding repeat
H0O22_00425	COG2385	sporulation resulting in formation of a cellular spore
H0O22_00430	COG0363	glucosamine-6-phosphate deaminase activity
H0O22_00435	COG0217	transcriptional regulatory protein
H0O22_00440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0O22_00445	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H0O22_00450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H0O22_00455	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H0O22_00460	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H0O22_00470	COG4251	negative regulation of phosphorylation
H0O22_00475	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H0O22_00480	COG5002	protein histidine kinase activity
H0O22_00485	COG0151	Belongs to the GarS family
H0O22_00495	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H0O22_00500	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0O22_00505	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H0O22_00510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0O22_00515	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0O22_00520	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0O22_00525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0O22_00540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H0O22_00555	COG2197	response regulator
H0O22_00565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0O22_00575	COG0284	orotidine-5'-phosphate decarboxylase activity
H0O22_00580	COG0438	transferase activity, transferring glycosyl groups
H0O22_00595	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H0O22_00600	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H0O22_00605	COG0321	lipoyl(octanoyl) transferase activity
H0O22_00610	COG1022	Amp-dependent synthetase and ligase
H0O22_00620	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0O22_00625	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H0O22_00630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0O22_00670	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H0O22_00710	COG0625	glutathione transferase activity
H0O22_00780	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H0O22_00815	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H0O22_00820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H0O22_00825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0O22_00830	COG2135	peptidase activity
H0O22_00840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0O22_00840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0O22_00875	COG0745	RESPONSE REGULATOR receiver
H0O22_00880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0O22_00885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H0O22_00890	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H0O22_00900	COG0196	riboflavin kinase activity
H0O22_00935	COG1691	(AIR) carboxylase
H0O22_00945	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H0O22_00955	COG0330	HflC and HflK could
H0O22_00960	COG0336	Belongs to the RNA methyltransferase TrmD family
H0O22_00970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0O22_00985	COG1702	phosphate starvation-inducible protein PhoH
H0O22_00990	COG0228	four-way junction DNA binding
H0O22_00995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0O22_01005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H0O22_01010	COG0123	including yeast histone deacetylase and acetoin utilization protein
H0O22_01025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0O22_01030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0O22_01030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H0O22_01035	COG0482	sulfurtransferase activity
H0O22_01045	COG1492	cobalamin metabolic process
H0O22_01055	COG0424	maF-like protein
H0O22_01075	COG2010	Cytochrome c
H0O22_01090	COG0159	tryptophan synthase activity
H0O22_01125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0O22_01130	COG1845	cytochrome c oxidase, subunit III
H0O22_01165	COG1840	ABC-type Fe3 transport system, periplasmic component
H0O22_01170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0O22_01195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H0O22_01200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0O22_01285	COG2226	methyltransferase
H0O22_01300	COG2113	Glycine betaine
H0O22_01305	COG4176	ABC-type proline glycine betaine transport system permease component
H0O22_01315	COG2226	methyltransferase
H0O22_01320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H0O22_01340	COG0367	asparagine synthase
H0O22_01360	COG0366	Alpha amylase catalytic
H0O22_01365	COG0463	Glycosyl transferase, family 2
H0O22_01380	COG2326	polyphosphate kinase activity
H0O22_01515	COG0659	secondary active sulfate transmembrane transporter activity
H0O22_01645	COG2124	cytochrome p450
H0O22_01815	COG2132	Multicopper oxidase
H0O22_01865	COG4942	peptidase
H0O22_01875	COG0251	oxidation-reduction process
H0O22_01885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0O22_01890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0O22_01895	COG1132	(ABC) transporter
H0O22_01905	COG0456	acetyltransferase
H0O22_01920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0O22_01925	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0O22_01945	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0O22_01950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0O22_01960	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H0O22_01990	COG4451	ribulose bisphosphate carboxylase, small
H0O22_01995	COG1850	ribulose-bisphosphate carboxylase activity
H0O22_02000	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H0O22_02015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H0O22_02020	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H0O22_02040	COG0531	amino acid
H0O22_02045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H0O22_02050	COG0659	secondary active sulfate transmembrane transporter activity
H0O22_02075	COG0004	ammonium transporteR
H0O22_02085	COG1959	2 iron, 2 sulfur cluster binding
H0O22_02090	COG0471	metal ion transport
H0O22_02090	COG3273	potassium ion transport
H0O22_02100	COG1253	flavin adenine dinucleotide binding
H0O22_02105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0O22_02110	COG0569	domain protein
H0O22_02115	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H0O22_02120	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H0O22_02125	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
H0O22_02175	COG0095	Lipoate-protein ligase
H0O22_02180	COG0517	IMP dehydrogenase activity
H0O22_02180	COG1994	Peptidase M50
H0O22_02185	COG0135	phosphoribosylanthranilate isomerase activity
H0O22_02195	COG0302	gtp cyclohydrolase
H0O22_02200	COG4221	oxidoreductase activity
H0O22_02205	COG0825	malonyl-CoA metabolic process
H0O22_02210	COG5322	oxidoreductase activity
H0O22_02215	COG3396	Phenylacetate-CoA oxygenase
H0O22_02225	COG0539	negative regulation of cytoplasmic translation
H0O22_02235	COG1496	oxidoreductase activity
H0O22_02240	COG0415	Belongs to the DNA photolyase family
H0O22_02250	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H0O22_02275	COG0028	Belongs to the TPP enzyme family
H0O22_02285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H0O22_02305	COG0528	UMP kinase activity
H0O22_02310	COG0233	cytoplasmic translational termination
H0O22_02325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0O22_02330	COG0768	penicillin binding
H0O22_02350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H0O22_02355	COG0681	Belongs to the peptidase S26 family
H0O22_02380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0O22_02390	COG0442	prolyl-tRNA aminoacylation
H0O22_02405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0O22_02410	COG1324	tolerance protein
H0O22_02415	COG2099	Precorrin-6x reductase
H0O22_02420	COG0629	single-stranded DNA binding
H0O22_02435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0O22_02445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0O22_02450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0O22_02455	COG1215	transferase activity, transferring glycosyl groups
H0O22_02460	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H0O22_02475	COG0181	hydroxymethylbilane synthase activity
H0O22_02490	COG1611	Belongs to the LOG family
H0O22_02515	COG0432	Pfam Uncharacterised protein family UPF0047
H0O22_02530	COG2154	pterin-4-alpha-carbinolamine dehydratase
H0O22_02535	COG0367	asparagine synthase
H0O22_02565	COG2010	Cytochrome c
H0O22_02575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H0O22_02580	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H0O22_02620	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H0O22_02655	COG0339	signal peptide processing
H0O22_02660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0O22_02665	COG0083	homoserine kinase activity
H0O22_02670	COG0837	glucose binding
H0O22_02675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H0O22_02690	COG0180	Tryptophanyl-tRNA synthetase
H0O22_02730	COG1799	cell septum assembly
H0O22_02740	COG1121	(ABC) transporter
H0O22_02745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0O22_02760	COG0681	Belongs to the peptidase S26 family
H0O22_02765	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H0O22_02770	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H0O22_02775	COG1376	ErfK ybiS ycfS ynhG family protein
H0O22_02780	COG0297	glycogen (starch) synthase activity
H0O22_02790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0O22_02800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H0O22_02805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0O22_02805	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H0O22_02810	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H0O22_02825	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H0O22_02830	COG2045	Belongs to the ComB family
H0O22_02840	COG0860	N-Acetylmuramoyl-L-alanine amidase
H0O22_02845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0O22_02850	COG0142	geranyltranstransferase activity
H0O22_02855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0O22_02860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0O22_02870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0O22_02905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0O22_02915	COG1132	(ABC) transporter
H0O22_02925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0O22_02930	COG0505	Belongs to the CarA family
H0O22_02940	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H0O22_02945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0O22_02955	COG0154	amidase activity
H0O22_02960	COG0587	DNA-directed DNA polymerase activity
H0O22_02970	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H0O22_02975	COG0632	four-way junction helicase activity
H0O22_02990	COG0358	DNA primase activity
H0O22_03005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H0O22_03025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0O22_03030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H0O22_03040	COG0022	dehydrogenase e1 component
H0O22_03045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0O22_03050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0O22_03065	COG0628	permease
H0O22_03070	COG3310	Protein conserved in bacteria
H0O22_03075	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H0O22_03080	COG0515	serine threonine protein kinase
H0O22_03115	COG0174	glutamine synthetase
H0O22_03125	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H0O22_03130	COG0590	tRNA wobble adenosine to inosine editing
H0O22_03145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H0O22_03150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H0O22_03170	COG0612	Peptidase, M16
H0O22_03190	COG1136	(ABC) transporter
H0O22_03200	COG1216	Glycosyl transferase, family 2
H0O22_03205	COG0052	Belongs to the universal ribosomal protein uS2 family
H0O22_03210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H0O22_03220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0O22_03225	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H0O22_03230	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0O22_03235	COG0751	glycine-tRNA ligase activity
H0O22_03245	COG0644	oxidoreductase
H0O22_03255	COG0826	peptidase U32
H0O22_03260	COG1217	gtp-binding protein TYPA
H0O22_03275	COG1137	ATPase activity
H0O22_03285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H0O22_03290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0O22_03295	COG1494	fructose-1,6-bisphosphatase
H0O22_03300	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H0O22_03305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H0O22_03310	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H0O22_03315	COG0363	glucosamine-6-phosphate deaminase activity
H0O22_03330	COG0129	dihydroxy-acid dehydratase activity
H0O22_03340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H0O22_03345	COG1357	PFAM Pentapeptide repeats (8 copies)
H0O22_03365	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0O22_03370	COG0047	phosphoribosylformylglycinamidine synthase activity
H0O22_03375	COG1619	proteins homologs of microcin C7 resistance protein MccF
H0O22_03380	COG0450	alkyl hydroperoxide reductase
H0O22_03390	COG0745	RESPONSE REGULATOR receiver
H0O22_03425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H0O22_03460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0O22_03470	COG0557	exoribonuclease II activity
H0O22_03475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H0O22_03480	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H0O22_03485	COG0072	phenylalanine-tRNA ligase activity
H0O22_03490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H0O22_03530	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H0O22_03550	COG0646	methionine synthase
H0O22_03550	COG1410	methionine synthase
H0O22_03555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0O22_03570	COG0613	PHP domain protein
H0O22_03575	COG1981	membrane
H0O22_03580	COG3046	protein related to deoxyribodipyrimidine photolyase
H0O22_03590	COG0322	excinuclease ABC activity
H0O22_03595	COG0426	domain, Protein
H0O22_03595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0O22_03600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H0O22_03625	COG1104	cysteine desulfurase activity
H0O22_03630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H0O22_03640	COG0495	leucyl-tRNA aminoacylation
H0O22_03645	COG0166	Belongs to the GPI family
H0O22_03670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H0O22_03675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H0O22_03680	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0O22_03680	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0O22_03685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0O22_03690	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H0O22_03695	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H0O22_03705	COG0484	heat shock protein binding
H0O22_03710	COG0443	Heat shock 70 kDa protein
H0O22_03715	COG0573	inorganic phosphate transmembrane transporter activity
H0O22_03720	COG0581	inorganic phosphate transmembrane transporter activity
H0O22_03725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0O22_03735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0O22_03740	COG0483	inositol monophosphate 1-phosphatase activity
H0O22_03745	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H0O22_03780	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H0O22_03785	COG1653	transport
H0O22_03820	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H0O22_03825	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0O22_03830	COG0668	transmembrane transport
H0O22_03835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H0O22_03840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0O22_03850	COG2308	Evidence 4 Homologs of previously reported genes of
H0O22_03895	COG4191	Histidine kinase
H0O22_03895	COG0784	Response regulator, receiver
H0O22_03900	COG1122	ATPase activity
H0O22_03910	COG1051	belongs to the nudix hydrolase family
H0O22_03975	COG0284	orotidine-5'-phosphate decarboxylase activity
H0O22_03975	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H0O22_03985	COG1131	(ABC) transporter
H0O22_04020	COG2226	methyltransferase
H0O22_04070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H0O22_04075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0O22_04100	COG0469	pyruvate kinase activity
H0O22_04105	COG0577	efflux transmembrane transporter activity
H0O22_04105	COG1136	(ABC) transporter
H0O22_04115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0O22_04125	COG0740	serine-type endopeptidase activity
H0O22_04140	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H0O22_04155	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H0O22_04240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H0O22_04245	COG0477	Major facilitator Superfamily
H0O22_04255	COG1175	transmembrane transport
H0O22_04260	COG0514	ATP-dependent DNA helicase (RecQ)
H0O22_04265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H0O22_04300	COG3588	fructose-bisphosphate aldolase
H0O22_04310	COG1793	dna ligase
H0O22_04315	COG1201	RNA secondary structure unwinding
H0O22_04375	COG0625	glutathione transferase activity
H0O22_04390	COG0516	GMP reductase activity
H0O22_04390	COG0517	IMP dehydrogenase activity
H0O22_04395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0O22_04410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H0O22_04420	COG2197	response regulator
H0O22_04425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0O22_04430	COG0114	fumarate hydratase activity
H0O22_04435	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H0O22_04450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0O22_04465	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H0O22_04470	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0O22_04475	COG0473	3-isopropylmalate dehydrogenase activity
H0O22_04480	COG3954	Phosphoribulokinase
H0O22_04490	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H0O22_04495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H0O22_04505	COG0673	inositol 2-dehydrogenase activity
H0O22_04510	COG0191	fructose-bisphosphate aldolase activity
H0O22_04520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0O22_04525	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H0O22_04535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0O22_04540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H0O22_04555	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H0O22_04555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0O22_04570	COG2119	membrane
H0O22_04580	COG0557	exoribonuclease II activity
H0O22_04585	COG0163	prenyltransferase activity
H0O22_04600	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H0O22_04605	COG0312	modulator of DNA gyrase
H0O22_04615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H0O22_04625	COG0513	Belongs to the DEAD box helicase family
H0O22_04640	COG0861	Integral membrane protein TerC family
H0O22_04660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0O22_04670	COG0793	Belongs to the peptidase S41A family
H0O22_04675	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H0O22_04680	COG1573	uracil-dna glycosylase
H0O22_04690	COG0436	Aminotransferase
H0O22_04695	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H0O22_04705	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H0O22_04710	COG3639	organic phosphonate transmembrane transporter activity
H0O22_04720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0O22_04730	COG1836	PFAM Integral membrane protein DUF92
H0O22_04750	COG1122	ATPase activity
H0O22_04755	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H0O22_04775	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H0O22_04780	COG4106	trans-aconitate 2-methyltransferase activity
H0O22_04815	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
H0O22_04840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H0O22_04850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0O22_04855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H0O22_04865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H0O22_04870	COG1429	ligase activity, forming nitrogen-metal bonds
H0O22_04875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0O22_04880	COG0149	triose-phosphate isomerase activity
H0O22_04890	COG1132	(ABC) transporter
H0O22_04905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0O22_04915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0O22_04935	COG1741	Belongs to the pirin family
H0O22_04950	COG1773	rubredoxin
H0O22_04970	COG3659	wide pore channel activity
H0O22_04980	COG0745	RESPONSE REGULATOR receiver
H0O22_04985	COG5002	protein histidine kinase activity
H0O22_04990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0O22_05000	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H0O22_05015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0O22_05020	COG0581	inorganic phosphate transmembrane transporter activity
H0O22_05025	COG0573	inorganic phosphate transmembrane transporter activity
H0O22_05035	COG0640	Transcriptional regulator
H0O22_05040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0O22_05075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0O22_05085	COG0709	Synthesizes selenophosphate from selenide and ATP
H0O22_05090	COG2271	Major facilitator Superfamily
H0O22_05095	COG1126	abc transporter atp-binding protein
H0O22_05100	COG0765	amino acid transport
H0O22_05105	COG4597	amino acid ABC transporter
H0O22_05110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0O22_05115	COG1872	DUF167
H0O22_05125	COG0418	dihydroorotase activity
H0O22_05195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0O22_05200	COG0300	oxidoreductase activity
H0O22_05205	COG1115	amino acid carrier protein
H0O22_05225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H0O22_05235	COG0799	negative regulation of ribosome biogenesis
H0O22_05250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0O22_05280	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H0O22_05430	COG2197	response regulator
H0O22_05485	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H0O22_05525	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H0O22_05530	COG0271	Belongs to the BolA IbaG family
H0O22_05540	COG0204	Acyl-transferase
H0O22_05540	COG0318	PFAM AMP-dependent synthetase and ligase
H0O22_05545	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0O22_05565	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H0O22_05570	COG1074	ATP-dependent DNA helicase activity
H0O22_05575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0O22_05580	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H0O22_05580	COG0662	Cupin 2, conserved barrel domain protein
H0O22_05585	COG0513	Belongs to the DEAD box helicase family
H0O22_05595	COG0724	RNA recognition motif
H0O22_05600	COG1132	(ABC) transporter
H0O22_05605	COG1316	TRANSCRIPTIONal
H0O22_05640	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H0O22_05660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0O22_05665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0O22_05690	COG1054	Belongs to the UPF0176 family
H0O22_05695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H0O22_05700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0O22_05705	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H0O22_05710	COG0019	diaminopimelate decarboxylase activity
H0O22_05715	COG0456	acetyltransferase
H0O22_05720	COG0542	response to heat
H0O22_05765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0O22_05780	COG0371	Dehydrogenase
H0O22_05795	COG0575	Belongs to the CDS family
H0O22_05800	COG2242	protein methyltransferase activity
H0O22_05800	COG2241	protein methyltransferase activity
H0O22_05805	COG1982	Orn Lys Arg decarboxylase major
H0O22_05810	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0O22_05820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0O22_05825	COG1187	pseudouridine synthase activity
H0O22_05840	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
H0O22_05855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0O22_05870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0O22_05910	COG0308	aminopeptidase N
H0O22_05930	COG2205	protein histidine kinase activity
H0O22_05945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H0O22_05950	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H0O22_05955	COG3409	Peptidoglycan-binding domain 1 protein
H0O22_05955	COG3429	Glucose-6-phosphate dehydrogenase subunit
H0O22_05960	COG1797	cobyrinic acid a,c-diamide synthase activity
H0O22_05965	COG0406	alpha-ribazole phosphatase activity
H0O22_05970	COG1254	Belongs to the acylphosphatase family
H0O22_05990	COG0142	geranyltranstransferase activity
H0O22_06000	COG1480	7TM receptor with intracellular HD hydrolase
H0O22_06010	COG0564	pseudouridine synthase activity
H0O22_06025	COG1799	cell septum assembly
H0O22_06060	COG0436	Aminotransferase
H0O22_06065	COG0395	ABC-type sugar transport system, permease component
H0O22_06070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0O22_06080	COG1543	Belongs to the glycosyl hydrolase 57 family
H0O22_06090	COG0644	oxidoreductase
H0O22_06095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H0O22_06110	COG0516	GMP reductase activity
H0O22_06115	COG3118	belongs to the thioredoxin family
H0O22_06120	COG1611	Belongs to the LOG family
H0O22_06125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0O22_06130	COG0116	Belongs to the methyltransferase superfamily
H0O22_06130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H0O22_06140	COG2010	Cytochrome c
H0O22_06145	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H0O22_06160	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H0O22_06165	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H0O22_06185	COG2166	iron-sulfur cluster assembly
H0O22_06190	COG0460	homoserine dehydrogenase
H0O22_06205	COG0601	transmembrane transport
H0O22_06290	COG0012	GTP binding
H0O22_06300	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H0O22_06310	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H0O22_06315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H0O22_06330	COG0194	GDP metabolic process
H0O22_06335	COG1293	RNA-binding protein homologous to eukaryotic snRNP
H0O22_06340	COG0805	protein transport
H0O22_06350	COG0723	plastoquinol--plastocyanin reductase activity
H0O22_06355	COG0739	heme binding
H0O22_06375	COG0248	Ppx GppA phosphatase
H0O22_06380	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H0O22_06385	COG1619	proteins homologs of microcin C7 resistance protein MccF
H0O22_06390	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H0O22_06405	COG1028	Short-chain dehydrogenase reductase Sdr
H0O22_06415	COG0459	protein refolding
H0O22_06425	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H0O22_06445	COG0109	protoheme IX farnesyltransferase activity
H0O22_06450	COG1612	heme a metabolic process
H0O22_06460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0O22_06465	COG1845	cytochrome c oxidase, subunit III
H0O22_06500	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H0O22_06515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H0O22_06520	COG1007	ATP synthesis coupled electron transport
H0O22_06525	COG0577	efflux transmembrane transporter activity
H0O22_06525	COG1136	(ABC) transporter
H0O22_06530	COG0739	heme binding
H0O22_06540	COG0436	Aminotransferase
H0O22_06545	COG3118	belongs to the thioredoxin family
H0O22_06550	COG1842	Phage shock protein A
H0O22_06565	COG0438	transferase activity, transferring glycosyl groups
H0O22_06570	COG0697	spore germination
H0O22_06575	COG0616	signal peptide processing
H0O22_06590	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H0O22_06595	COG0594	ribonuclease P activity
H0O22_06605	COG0706	membrane insertase activity
H0O22_06615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0O22_06690	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H0O22_06700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0O22_06710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H0O22_06715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H0O22_06730	COG0134	indole-3-glycerol-phosphate synthase activity
H0O22_06735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0O22_06740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0O22_06755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H0O22_06760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0O22_06765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0O22_06770	COG0285	dihydrofolate synthase activity
H0O22_06805	COG4948	Mandelate Racemase Muconate Lactonizing
H0O22_06810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0O22_06815	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0O22_06830	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0O22_06845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0O22_06850	COG4956	integral membrane protein (PIN domain superfamily)
H0O22_06855	COG0740	serine-type endopeptidase activity
H0O22_06860	COG0740	serine-type endopeptidase activity
H0O22_06865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H0O22_06870	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H0O22_06875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0O22_06880	COG0438	transferase activity, transferring glycosyl groups
H0O22_06900	COG0752	glycyl-tRNA synthetase alpha subunit
H0O22_06910	COG2226	methyltransferase
H0O22_06920	COG0107	imidazoleglycerol-phosphate synthase activity
H0O22_06930	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H0O22_06940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H0O22_06940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0O22_06945	COG3695	enzyme binding
H0O22_06950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0O22_06970	COG0745	RESPONSE REGULATOR receiver
H0O22_06985	COG2274	protein secretion by the type I secretion system
H0O22_07000	COG0481	GTPase activity
H0O22_07005	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H0O22_07010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H0O22_07015	COG0579	oxidoreductase
H0O22_07020	COG0750	zinc metalloprotease
H0O22_07025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H0O22_07030	COG1185	polyribonucleotide nucleotidyltransferase activity
H0O22_07040	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H0O22_07125	COG0484	heat shock protein binding
H0O22_07130	COG4243	Vitamin k epoxide reductase
H0O22_07200	COG0523	cobalamin synthesis protein
H0O22_07215	COG3659	wide pore channel activity
H0O22_07225	COG3128	pkhd-type hydroxylase
H0O22_07230	COG1840	ABC-type Fe3 transport system, periplasmic component
H0O22_07270	COG0116	Belongs to the methyltransferase superfamily
H0O22_07275	COG3263	regulation of cellular component size
H0O22_07290	COG1196	nuclear chromosome segregation
H0O22_07300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0O22_07315	COG0439	Biotin carboxylase
H0O22_07330	COG0515	serine threonine protein kinase
H0O22_07350	COG4178	(ABC) transporter
H0O22_07355	COG0537	adenosine 5'-monophosphoramidase activity
H0O22_07370	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H0O22_07385	COG0242	peptide deformylase activity
H0O22_07390	COG1073	alpha beta
H0O22_07400	COG0235	Class ii aldolase
H0O22_07405	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H0O22_07415	COG2226	methyltransferase
H0O22_07420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H0O22_07425	COG0719	Fe-S assembly protein
H0O22_07430	COG0396	ATPase activity
H0O22_07435	COG0719	Fe-S assembly protein
H0O22_07440	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
H0O22_07465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H0O22_07555	COG2094	Belongs to the DNA glycosylase MPG family
H0O22_07605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H0O22_07605	COG2755	lipolytic protein G-D-S-L family
H0O22_07670	COG0033	Phosphoglucomutase
H0O22_07685	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0O22_07700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0O22_07705	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H0O22_07710	COG0175	sulfate reduction
H0O22_07715	COG1252	NADH dehydrogenase
H0O22_07725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0O22_07730	COG0450	alkyl hydroperoxide reductase
H0O22_07735	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H0O22_07745	COG0488	(ABC) transporter
H0O22_07755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0O22_07770	COG1643	Atp-dependent helicase
H0O22_07785	COG1570	exodeoxyribonuclease VII activity
H0O22_07840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H0O22_07845	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H0O22_07850	COG0793	Belongs to the peptidase S41A family
H0O22_07855	COG1078	dGTPase activity
H0O22_07860	COG0850	regulation of cytokinetic process
H0O22_07865	COG2059	Chromate
H0O22_07880	COG2894	cell division
H0O22_07885	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H0O22_07925	COG0463	Glycosyl transferase, family 2
H0O22_07930	COG5505	Protein of unknown function (DUF819)
H0O22_07950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0O22_07960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0O22_07965	COG0254	rRNA binding
H0O22_07970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0O22_07975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0O22_07980	COG0101	tRNA pseudouridine synthase activity
H0O22_07985	COG0203	ribosomal protein L17
H0O22_07990	COG0202	RNA polymerase activity
H0O22_07995	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H0O22_08000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H0O22_08005	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H0O22_08010	COG0563	adenylate kinase activity
H0O22_08015	COG0201	protein transport
H0O22_08020	COG0200	Binds to the 23S rRNA
H0O22_08025	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H0O22_08030	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H0O22_08035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H0O22_08045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H0O22_08050	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H0O22_08055	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H0O22_08060	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H0O22_08065	COG0255	Belongs to the universal ribosomal protein uL29 family
H0O22_08070	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H0O22_08075	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H0O22_08080	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H0O22_08085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H0O22_08090	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H0O22_08095	COG0089	rRNA binding
H0O22_08100	COG0088	Forms part of the polypeptide exit tunnel
H0O22_08105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H0O22_08120	COG3854	ATPases associated with a variety of cellular activities
H0O22_08165	COG3001	Fructosamine kinase
H0O22_08185	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H0O22_08190	COG1606	tRNA processing
H0O22_08200	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H0O22_08205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H0O22_08220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H0O22_08225	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H0O22_08230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0O22_08245	COG0772	Belongs to the SEDS family
H0O22_08250	COG0489	protein tyrosine kinase activity
H0O22_08255	COG0408	coproporphyrinogen oxidase activity
H0O22_08275	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H0O22_08315	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H0O22_08320	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H0O22_08325	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H0O22_08325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H0O22_08330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0O22_08355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H0O22_08455	COG0237	dephospho-CoA kinase activity
H0O22_08475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H0O22_08515	COG1070	Carbohydrate kinase
H0O22_08520	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0O22_08525	COG0546	phosphoglycolate phosphatase activity
H0O22_08530	COG0539	negative regulation of cytoplasmic translation
H0O22_08535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H0O22_08560	COG0589	response to stress
H0O22_08565	COG0824	Thioesterase
H0O22_08600	COG2890	protein-(glutamine-N5) methyltransferase activity
H0O22_08605	COG0009	L-threonylcarbamoyladenylate synthase
H0O22_08615	COG2885	chlorophyll binding
H0O22_08620	COG2885	chlorophyll binding
H0O22_08640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0O22_08650	COG0067	glutamate synthase
H0O22_08650	COG0069	glutamate synthase activity
H0O22_08650	COG0070	glutamate synthase
H0O22_08665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H0O22_08670	COG0049	tRNA binding
H0O22_08680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0O22_08685	COG0051	transcription antitermination factor activity, RNA binding
H0O22_08695	COG2226	methyltransferase
H0O22_08700	COG1605	Chorismate mutase
H0O22_08700	COG0077	Prephenate dehydratase
H0O22_08710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0O22_08715	COG1530	ribonuclease E activity
H0O22_08725	COG0436	Aminotransferase
H0O22_08730	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H0O22_08745	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H0O22_08760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0O22_08765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H0O22_08780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0O22_08785	COG0529	Catalyzes the synthesis of activated sulfate
H0O22_08785	COG2046	Belongs to the sulfate adenylyltransferase family
H0O22_08800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H0O22_08805	COG3536	Protein conserved in bacteria
H0O22_08830	COG0540	Belongs to the ATCase OTCase family
H0O22_08835	COG2094	Belongs to the DNA glycosylase MPG family
H0O22_08855	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0O22_08875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0O22_08895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0O22_08910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0O22_08915	COG0739	heme binding
H0O22_08915	COG0741	lytic transglycosylase activity
H0O22_08915	COG1196	nuclear chromosome segregation
H0O22_08930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0O22_08945	COG0717	Belongs to the dCTP deaminase family
H0O22_08950	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H0O22_08955	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H0O22_08960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0O22_08965	COG4372	Transposase
H0O22_08980	COG0193	aminoacyl-tRNA hydrolase activity
H0O22_08985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H0O22_09020	COG0066	3-isopropylmalate dehydratase activity
H0O22_09025	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0O22_09030	COG1058	Belongs to the CinA family
H0O22_09030	COG1546	Belongs to the CinA family
H0O22_09035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0O22_09040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H0O22_09065	COG0728	peptidoglycan biosynthetic process
H0O22_09070	COG1489	DNA binding
H0O22_09075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H0O22_09090	COG0138	bifunctional purine biosynthesis protein purh
H0O22_09105	COG2205	protein histidine kinase activity
H0O22_09115	COG0343	queuine tRNA-ribosyltransferase activity
H0O22_09135	COG0463	Glycosyl transferase, family 2
H0O22_09160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0O22_09165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0O22_09175	COG0673	inositol 2-dehydrogenase activity
H0O22_09180	COG1253	flavin adenine dinucleotide binding
H0O22_09195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H0O22_09200	COG0354	folic acid binding
H0O22_09210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0O22_09215	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H0O22_09220	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H0O22_09225	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H0O22_09265	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
H0O22_09280	COG0131	Imidazoleglycerol-phosphate dehydratase
H0O22_09285	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H0O22_09290	COG0415	Belongs to the DNA photolyase family
H0O22_09320	COG0415	Belongs to the DNA photolyase family
H0O22_09325	COG1083	cytidylyl-transferase
H0O22_09335	COG2089	acid synthase
H0O22_09350	COG0494	nUDIX hydrolase
H0O22_09360	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H0O22_09360	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H0O22_09370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0O22_09375	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H0O22_09380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0O22_09385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0O22_09390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0O22_09395	COG1773	rubredoxin
H0O22_09400	COG4447	cellulose binding
H0O22_09425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0O22_09490	COG0438	transferase activity, transferring glycosyl groups
H0O22_09530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0O22_09535	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H0O22_09595	COG0463	Glycosyl transferase, family 2
H0O22_09610	COG0438	transferase activity, transferring glycosyl groups
H0O22_09620	COG0124	histidyl-tRNA synthetase
H0O22_09630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0O22_09635	COG0517	IMP dehydrogenase activity
H0O22_09635	COG0617	tRNA 3'-terminal CCA addition
H0O22_09635	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H0O22_09645	COG1132	(ABC) transporter
H0O22_09655	COG5398	heme oxygenase
H0O22_09665	COG0538	isocitrate dehydrogenase activity
H0O22_09680	COG2192	nodulation
H0O22_09685	COG0247	lactate metabolic process
H0O22_09690	COG0438	transferase activity, transferring glycosyl groups
H0O22_09700	COG0531	amino acid
H0O22_09710	COG0277	FAD linked oxidase domain protein
H0O22_09730	COG0463	Glycosyl transferase, family 2
H0O22_09750	COG0724	RNA recognition motif
H0O22_09755	COG0165	Argininosuccinate lyase
H0O22_09760	COG2208	phosphoserine phosphatase activity
H0O22_09765	COG0552	protein localization to endoplasmic reticulum
H0O22_09770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0O22_09785	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H0O22_09795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H0O22_09800	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H0O22_09805	COG0107	imidazoleglycerol-phosphate synthase activity
H0O22_09815	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H0O22_09820	COG2089	acid synthase
H0O22_09830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0O22_09835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0O22_09840	COG1083	cytidylyl-transferase
H0O22_09850	COG0107	imidazoleglycerol-phosphate synthase activity
H0O22_09855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0O22_09860	COG1028	Short-chain dehydrogenase reductase Sdr
H0O22_09865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0O22_09870	COG0497	DNA recombination
H0O22_09875	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0O22_09885	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0O22_09890	COG0592	DNA-directed DNA polymerase activity
H0O22_09905	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H0O22_09945	COG2082	Precorrin-8x methylmutase
H0O22_09950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H0O22_09960	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H0O22_09990	COG0653	protein targeting
H0O22_09995	COG1045	serine acetyltransferase
H0O22_10005	COG1725	Transcriptional regulator
H0O22_10010	COG0412	Dienelactone hydrolase
H0O22_10015	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H0O22_10020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H0O22_10025	COG0187	DNA topoisomerase II activity
H0O22_10025	COG1372	Participates in initiation and elongation during chromosome replication
H0O22_10035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H0O22_10040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H0O22_10045	COG0386	Belongs to the glutathione peroxidase family
H0O22_10050	COG2239	Acts as a magnesium transporter
H0O22_10055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0O22_10060	COG1132	(ABC) transporter
H0O22_10075	COG0802	atpase or kinase
H0O22_10080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H0O22_10085	COG0629	single-stranded DNA binding
H0O22_10110	COG0745	RESPONSE REGULATOR receiver
H0O22_10115	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H0O22_10145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0O22_10175	COG1473	amidohydrolase
H0O22_10190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0O22_10190	COG0517	IMP dehydrogenase activity
H0O22_10195	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H0O22_10200	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H0O22_10215	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H0O22_10220	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H0O22_10255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H0O22_10260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0O22_10265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0O22_10270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0O22_10275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0O22_10280	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H0O22_10280	COG0662	Cupin 2, conserved barrel domain protein
H0O22_10285	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0O22_10295	COG0571	ribonuclease III activity
H0O22_10320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H0O22_10325	COG0058	SHG alpha-glucan phosphorylase activity
H0O22_10335	COG0475	glutathione-regulated potassium exporter activity
H0O22_10345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0O22_10350	COG2081	HI0933 family
H0O22_10355	COG1459	type II secretion system
H0O22_10370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H0O22_10375	COG0484	heat shock protein binding
H0O22_10385	COG1162	GTPase activity
H0O22_10390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H0O22_10395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H0O22_10400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0O22_10405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0O22_10410	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0O22_10415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0O22_10420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0O22_10425	COG0511	ligase activity, forming carbon-carbon bonds
H0O22_10430	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0O22_10455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H0O22_10495	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
H0O22_10500	COG0519	Catalyzes the synthesis of GMP from XMP
H0O22_10500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0O22_10535	COG2022	thiamine diphosphate biosynthetic process
H0O22_10550	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H0O22_10555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H0O22_10560	COG2385	sporulation resulting in formation of a cellular spore
H0O22_10565	COG1215	transferase activity, transferring glycosyl groups
H0O22_10570	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0O22_10580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H0O22_10585	COG0740	serine-type endopeptidase activity
H0O22_10590	COG0544	peptidyl-prolyl cis-trans isomerase activity
H0O22_10595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H0O22_10600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0O22_10605	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H0O22_10615	COG0037	tRNA processing
H0O22_10625	COG0556	nucleotide-excision repair
H0O22_10630	COG0438	transferase activity, transferring glycosyl groups
H0O22_10635	COG1316	TRANSCRIPTIONal
H0O22_10640	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H0O22_10705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0O22_10720	COG0137	argininosuccinate synthase activity
H0O22_10730	COG0360	Binds together with S18 to 16S ribosomal RNA
H0O22_10740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H0O22_10745	COG0443	Heat shock 70 kDa protein
H0O22_10750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H0O22_10765	COG0788	formyltetrahydrofolate deformylase activity
H0O22_10800	COG1049	propionate catabolic process, 2-methylcitrate cycle
H0O22_10805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0O22_10815	COG0170	dolichyl monophosphate biosynthetic process
H0O22_10820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0O22_10825	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H0O22_10835	COG0315	cyclic pyranopterin monophosphate synthase activity
H0O22_10840	COG0303	'Molybdopterin
H0O22_10845	COG0314	molybdopterin synthase activity
H0O22_10855	COG0521	Mo-molybdopterin cofactor biosynthetic process
H0O22_10860	COG0730	response to heat
H0O22_10865	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H0O22_10870	COG0746	molybdenum cofactor guanylyltransferase activity
H0O22_10875	COG2223	nitrite transmembrane transporter activity
H0O22_10880	COG0243	molybdopterin cofactor binding
H0O22_10900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0O22_10905	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H0O22_10915	COG2116	formate transmembrane transporter activity
H0O22_10925	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0O22_10940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H0O22_10960	COG0804	urea catabolic process
H0O22_10965	COG0832	Belongs to the urease beta subunit family
H0O22_10970	COG0831	urea catabolic process
H0O22_10975	COG0829	nickel cation binding
H0O22_10980	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H0O22_10985	COG0830	nickel cation binding
H0O22_10990	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H0O22_11030	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H0O22_11035	COG0602	queuosine metabolic process
H0O22_11040	COG0504	CTP synthase activity
H0O22_11045	COG0783	Belongs to the Dps family
H0O22_11050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0O22_11055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H0O22_11060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H0O22_11075	COG0010	Belongs to the arginase family
H0O22_11080	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H0O22_11090	COG3956	TIGRFAM MazG family protein
H0O22_11110	COG0659	secondary active sulfate transmembrane transporter activity
H0O22_11115	COG0300	oxidoreductase activity
H0O22_11140	COG0525	valine-tRNA ligase activity
H0O22_11145	COG0398	Pfam SNARE associated Golgi protein
H0O22_11155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0O22_11190	COG0445	tRNA wobble uridine modification
H0O22_11195	COG1372	Participates in initiation and elongation during chromosome replication
H0O22_11195	COG0305	Participates in initiation and elongation during chromosome replication
H0O22_11195	COG0305	Participates in initiation and elongation during chromosome replication
H0O22_11195	COG1372	Participates in initiation and elongation during chromosome replication
H0O22_11200	COG0359	binds to the 23S rRNA
H0O22_11220	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H0O22_11225	COG0509	glycine decarboxylation via glycine cleavage system
H0O22_11245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0O22_11245	COG0426	domain, Protein
H0O22_11250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0O22_11250	COG0426	domain, Protein
H0O22_11255	COG0071	Belongs to the small heat shock protein (HSP20) family
H0O22_11270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H0O22_11280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H0O22_11290	COG1166	arginine decarboxylase activity
H0O22_11295	COG0105	UTP biosynthetic process
H0O22_11300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0O22_11300	COG2022	thiamine diphosphate biosynthetic process
H0O22_11305	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0O22_11310	COG0237	dephospho-CoA kinase activity
H0O22_11315	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H0O22_11370	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0O22_11375	COG0148	phosphopyruvate hydratase activity
H0O22_11380	COG0346	lactoylglutathione lyase activity
H0O22_11385	COG0542	response to heat
H0O22_11390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H0O22_11395	COG0250	Participates in transcription elongation, termination and antitermination
H0O22_11400	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H0O22_11405	COG0081	regulation of translation
H0O22_11410	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0O22_11415	COG0222	ribosome binding
H0O22_11425	COG0328	RNA-DNA hybrid ribonuclease activity
H0O22_11430	COG0167	dihydroorotate dehydrogenase activity
H0O22_11460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0O22_11465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H0O22_11475	COG2084	Dehydrogenase
H0O22_11500	COG0126	phosphoglycerate kinase activity
H0O22_11505	COG0589	response to stress
H0O22_11515	COG0564	pseudouridine synthase activity
H0O22_11520	COG4172	Belongs to the ABC transporter superfamily
H0O22_11525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0O22_11535	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H0O22_11540	COG0157	Belongs to the NadC ModD family
H0O22_11545	COG0018	arginyl-trna synthetase
H0O22_11550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0O22_11560	COG0512	Glutamine amidotransferase of anthranilate synthase
H0O22_11565	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H0O22_11570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H0O22_11585	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H0O22_11590	COG0189	ligase activity
H0O22_11595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0O22_11605	COG1575	Belongs to the MenA family. Type 1 subfamily
H0O22_11640	COG0649	NAD binding
H0O22_11665	COG0745	RESPONSE REGULATOR receiver
H0O22_11670	COG0564	pseudouridine synthase activity
H0O22_11675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H0O22_11680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H0O22_11685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H0O22_11690	COG0628	permease
H0O22_11695	COG0529	Catalyzes the synthesis of activated sulfate
H0O22_11700	COG0023	Translation Initiation Factor
H0O22_11710	COG0133	tryptophan synthase activity
H0O22_11715	COG1420	regulation of RNA biosynthetic process
H0O22_11720	COG1132	(ABC) transporter
H0O22_11725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H0O22_11725	COG0425	Belongs to the sulfur carrier protein TusA family
H0O22_11735	COG2062	phosphohistidine phosphatase, SixA
H0O22_11740	COG0372	Belongs to the citrate synthase family
H0O22_11745	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H0O22_11750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0O22_11755	COG0839	Belongs to the complex I subunit 6 family
H0O22_11760	COG0713	ATP synthesis coupled electron transport
H0O22_11765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0O22_11790	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H0O22_11805	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0O22_11810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0O22_11820	COG0583	DNA-binding transcription factor activity
H0O22_11835	COG0493	'glutamate synthase
H0O22_11835	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H0O22_11840	COG1562	ergosterol biosynthetic process
H0O22_11850	COG0724	RNA recognition motif
H0O22_11855	COG0617	tRNA 3'-terminal CCA addition
H0O22_11865	COG1214	PFAM Peptidase M22, glycoprotease
H0O22_11880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H0O22_11885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0O22_11890	COG0416	fatty acid biosynthetic process
H0O22_11900	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H0O22_11905	COG0457	Tetratricopeptide repeat
H0O22_11910	COG2217	Heavy metal translocating P-type atpase
H0O22_11915	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H0O22_11920	COG0470	DNA polymerase III
H0O22_11925	COG0745	RESPONSE REGULATOR receiver
H0O22_11935	COG1122	ATPase activity
H0O22_11950	COG2132	Multicopper oxidase
H0O22_11965	COG0463	Glycosyl transferase, family 2
H0O22_11980	COG3659	wide pore channel activity
H0O22_11985	COG3659	wide pore channel activity
H0O22_11990	COG0484	heat shock protein binding
H0O22_12000	COG1090	epimerase
H0O22_12020	COG0316	Belongs to the HesB IscA family
H0O22_12025	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H0O22_12040	COG1587	Uroporphyrinogen-III synthase
H0O22_12045	COG0457	Tetratricopeptide repeat
H0O22_12045	COG0463	Glycosyl transferase, family 2
H0O22_12050	COG1472	Belongs to the glycosyl hydrolase 3 family
H0O22_12055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H0O22_12080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H0O22_12110	COG1032	radical SAM domain protein
H0O22_12125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0O22_12130	COG4243	Vitamin k epoxide reductase
H0O22_12135	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H0O22_12140	COG1555	photosystem II stabilization
H0O22_12150	COG1968	undecaprenyl-diphosphatase activity
H0O22_12205	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H0O22_12210	COG0235	Class ii aldolase
H0O22_12215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H0O22_12230	COG0514	ATP-dependent DNA helicase (RecQ)
H0O22_12235	COG1388	LysM domain
H0O22_12235	COG3942	CHAP domain
H0O22_12240	COG1012	belongs to the aldehyde dehydrogenase family
H0O22_12260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H0O22_12285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0O22_12300	COG1160	GTP binding
H0O22_12305	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H0O22_12315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H0O22_12320	COG1799	cell septum assembly
H0O22_12325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H0O22_12330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H0O22_12345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0O22_12350	COG2211	Major facilitator Superfamily
H0O22_12360	COG1523	belongs to the glycosyl hydrolase 13 family
H0O22_12370	COG0776	regulation of translation
H0O22_12390	COG0113	porphobilinogen synthase activity
H0O22_12400	COG1193	negative regulation of DNA recombination
H0O22_12405	COG3842	ATPase activity
H0O22_12410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H0O22_12425	COG0488	(ABC) transporter
H0O22_12440	COG2988	succinylglutamate desuccinylase activity
H0O22_12460	COG3527	Alpha-acetolactate decarboxylase
H0O22_12495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H0O22_12505	COG0195	Participates in both transcription termination and antitermination
H0O22_12510	COG0779	Required for maturation of 30S ribosomal subunits
H0O22_12520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0O22_12525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0O22_12530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H0O22_12535	COG0519	Catalyzes the synthesis of GMP from XMP
H0O22_12535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0O22_12540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0O22_12545	COG0268	Binds directly to 16S ribosomal RNA
H0O22_12550	COG0084	hydrolase, TatD family'
H0O22_12555	COG0085	RNA polymerase activity
H0O22_12560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H0O22_12565	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H0O22_12570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H0O22_12575	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H0O22_12580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0O22_12610	COG0357	Ribosomal RNA small subunit methyltransferase G
H0O22_12615	COG0484	heat shock protein binding
H0O22_12630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H0O22_12645	COG0156	8-amino-7-oxononanoate synthase activity
H0O22_12650	COG4581	dead DEAH box helicase
H0O22_12655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H0O22_12660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H0O22_12670	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H0O22_12675	COG0347	Belongs to the P(II) protein family
H0O22_12680	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H0O22_12685	COG1333	cytochrome c biogenesis protein
H0O22_12695	COG0772	Belongs to the SEDS family
H0O22_12715	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H0O22_12720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H0O22_12740	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H0O22_12745	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H0O22_12760	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H0O22_12770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0O22_12780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0O22_12785	COG3012	SEC-C Motif Domain Protein
H0O22_12795	COG3631	Ketosteroid isomerase-related protein
H0O22_12810	COG0686	Belongs to the AlaDH PNT family
H0O22_12815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0O22_12815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0O22_12820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H0O22_12830	COG0006	proline dipeptidase activity
H0O22_12875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0O22_12885	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H0O22_12890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H0O22_12895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H0O22_12900	COG0459	protein refolding
H0O22_12915	COG0004	ammonium transporteR
H0O22_12925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0O22_12935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0O22_12940	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H0O22_13095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0O22_13100	COG0440	acetolactate synthase activity
H0O22_13185	COG1187	pseudouridine synthase activity