locus-tag	class	description
SynM161_00001	COG0592	DNA-directed DNA polymerase activity
SynM161_00003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynM161_00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynM161_00007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynM161_00010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynM161_00011	COG0552	protein localization to endoplasmic reticulum
SynM161_00012	COG2208	phosphoserine phosphatase activity
SynM161_00013	COG0165	Argininosuccinate lyase
SynM161_00014	COG0724	RNA recognition motif
SynM161_00015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynM161_00017	COG2081	HI0933 family
SynM161_00018	COG1459	type II secretion system
SynM161_00020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynM161_00021	COG0484	heat shock protein binding
SynM161_00023	COG1162	GTPase activity
SynM161_00024	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynM161_00025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynM161_00026	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynM161_00028	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynM161_00029	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynM161_00030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynM161_00031	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynM161_00032	COG0511	ligase activity, forming carbon-carbon bonds
SynM161_00033	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynM161_00048	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynM161_00049	COG0519	Catalyzes the synthesis of GMP from XMP
SynM161_00049	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynM161_00052	COG0768	penicillin binding
SynM161_00053	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynM161_00053	COG0438	transferase activity, transferring glycosyl groups
SynM161_00054	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynM161_00056	COG2022	thiamine diphosphate biosynthetic process
SynM161_00059	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynM161_00060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynM161_00061	COG2385	sporulation resulting in formation of a cellular spore
SynM161_00062	COG1215	transferase activity, transferring glycosyl groups
SynM161_00063	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynM161_00065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynM161_00066	COG0740	serine-type endopeptidase activity
SynM161_00067	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynM161_00068	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynM161_00069	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynM161_00070	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynM161_00074	COG2082	Precorrin-8x methylmutase
SynM161_00075	COG0037	tRNA processing
SynM161_00078	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynM161_00079	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynM161_00081	COG0556	nucleotide-excision repair
SynM161_00083	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynM161_00090	COG0653	protein targeting
SynM161_00096	COG1215	transferase activity, transferring glycosyl groups
SynM161_00097	COG0438	transferase activity, transferring glycosyl groups
SynM161_00097	COG1216	Glycosyl transferase, family 2
SynM161_00098	COG1215	transferase activity, transferring glycosyl groups
SynM161_00102	COG2192	nodulation
SynM161_00103	COG1045	serine acetyltransferase
SynM161_00104	COG1725	Transcriptional regulator
SynM161_00105	COG0412	Dienelactone hydrolase
SynM161_00106	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynM161_00107	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynM161_00108	COG0187	DNA topoisomerase II activity
SynM161_00108	COG1372	Participates in initiation and elongation during chromosome replication
SynM161_00110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynM161_00111	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynM161_00113	COG0386	Belongs to the glutathione peroxidase family
SynM161_00114	COG2239	Acts as a magnesium transporter
SynM161_00115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynM161_00116	COG0596	Alpha beta hydrolase
SynM161_00117	COG1194	a g-specific adenine glycosylase
SynM161_00119	COG0802	atpase or kinase
SynM161_00120	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynM161_00121	COG0586	Pfam SNARE associated Golgi protein
SynM161_00122	COG0629	single-stranded DNA binding
SynM161_00124	COG1792	Involved in formation and maintenance of cell shape
SynM161_00127	COG0745	RESPONSE REGULATOR receiver
SynM161_00128	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynM161_00133	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynM161_00134	COG2255	four-way junction helicase activity
SynM161_00136	COG1473	amidohydrolase
SynM161_00139	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynM161_00140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynM161_00141	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynM161_00142	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynM161_00143	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynM161_00144	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynM161_00145	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynM161_00145	COG0662	Cupin 2, conserved barrel domain protein
SynM161_00146	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynM161_00149	COG0571	ribonuclease III activity
SynM161_00153	COG0058	SHG alpha-glucan phosphorylase activity
SynM161_00154	COG0475	glutathione-regulated potassium exporter activity
SynM161_00158	COG0277	FAD linked oxidase domain protein
SynM161_00160	COG0247	lactate metabolic process
SynM161_00161	COG0538	isocitrate dehydrogenase activity
SynM161_00162	COG0463	Glycosyl transferase, family 2
SynM161_00164	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SynM161_00166	COG5398	heme oxygenase
SynM161_00168	COG1132	(ABC) transporter
SynM161_00169	COG0438	transferase activity, transferring glycosyl groups
SynM161_00170	COG0438	transferase activity, transferring glycosyl groups
SynM161_00171	COG0438	transferase activity, transferring glycosyl groups
SynM161_00172	COG0297	glycogen (starch) synthase activity
SynM161_00175	COG0617	tRNA 3'-terminal CCA addition
SynM161_00176	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynM161_00180	COG0709	Synthesizes selenophosphate from selenide and ATP
SynM161_00181	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynM161_00182	COG0124	histidyl-tRNA synthetase
SynM161_00183	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynM161_00184	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynM161_00190	COG4447	cellulose binding
SynM161_00191	COG1773	rubredoxin
SynM161_00192	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynM161_00193	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynM161_00194	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynM161_00195	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynM161_00196	COG3842	ATPase activity
SynM161_00198	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynM161_00198	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynM161_00200	COG1132	(ABC) transporter
SynM161_00201	COG0494	nUDIX hydrolase
SynM161_00202	COG0415	Belongs to the DNA photolyase family
SynM161_00209	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynM161_00210	COG0131	Imidazoleglycerol-phosphate dehydratase
SynM161_00211	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynM161_00212	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynM161_00216	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynM161_00217	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynM161_00219	COG0354	folic acid binding
SynM161_00220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynM161_00223	COG1253	flavin adenine dinucleotide binding
SynM161_00224	COG0673	inositol 2-dehydrogenase activity
SynM161_00228	COG0343	queuine tRNA-ribosyltransferase activity
SynM161_00229	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SynM161_00234	COG0138	bifunctional purine biosynthesis protein purh
SynM161_00237	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynM161_00238	COG0004	ammonium transporteR
SynM161_00239	COG1489	DNA binding
SynM161_00240	COG0728	peptidoglycan biosynthetic process
SynM161_00245	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynM161_00246	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynM161_00247	COG1058	Belongs to the CinA family
SynM161_00247	COG1546	Belongs to the CinA family
SynM161_00248	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynM161_00249	COG0066	3-isopropylmalate dehydratase activity
SynM161_00256	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynM161_00257	COG0193	aminoacyl-tRNA hydrolase activity
SynM161_00260	COG4372	Transposase
SynM161_00261	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynM161_00262	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynM161_00264	COG0717	Belongs to the dCTP deaminase family
SynM161_00266	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynM161_00267	COG0741	lytic transglycosylase activity
SynM161_00268	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynM161_00271	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynM161_00275	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynM161_00279	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynM161_00280	COG1402	creatininase
SynM161_00282	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynM161_00283	COG2094	Belongs to the DNA glycosylase MPG family
SynM161_00284	COG0540	Belongs to the ATCase OTCase family
SynM161_00289	COG3536	Protein conserved in bacteria
SynM161_00290	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynM161_00293	COG2046	Belongs to the sulfate adenylyltransferase family
SynM161_00293	COG0529	Catalyzes the synthesis of activated sulfate
SynM161_00294	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynM161_00297	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynM161_00300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynM161_00302	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynM161_00303	COG0436	Aminotransferase
SynM161_00305	COG1530	ribonuclease E activity
SynM161_00306	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynM161_00309	COG2226	methyltransferase
SynM161_00310	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynM161_00311	COG0051	transcription antitermination factor activity, RNA binding
SynM161_00312	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynM161_00313	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynM161_00314	COG0049	tRNA binding
SynM161_00315	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynM161_00316	COG0316	Belongs to the HesB IscA family
SynM161_00318	COG0070	glutamate synthase
SynM161_00318	COG0069	glutamate synthase activity
SynM161_00318	COG0067	glutamate synthase
SynM161_00320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynM161_00324	COG2885	chlorophyll binding
SynM161_00325	COG2885	chlorophyll binding
SynM161_00332	COG0463	Glycosyl transferase, family 2
SynM161_00336	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynM161_00338	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynM161_00339	COG0254	rRNA binding
SynM161_00340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynM161_00341	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynM161_00342	COG0101	tRNA pseudouridine synthase activity
SynM161_00343	COG0203	ribosomal protein L17
SynM161_00344	COG0202	RNA polymerase activity
SynM161_00345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynM161_00346	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynM161_00347	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynM161_00348	COG0563	adenylate kinase activity
SynM161_00349	COG0201	protein transport
SynM161_00350	COG0200	Binds to the 23S rRNA
SynM161_00351	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynM161_00352	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynM161_00353	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynM161_00354	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynM161_00355	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynM161_00356	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynM161_00357	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynM161_00358	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynM161_00359	COG0255	Belongs to the universal ribosomal protein uL29 family
SynM161_00360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynM161_00361	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynM161_00362	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynM161_00363	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynM161_00364	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynM161_00365	COG0089	rRNA binding
SynM161_00366	COG0088	Forms part of the polypeptide exit tunnel
SynM161_00367	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynM161_00371	COG3854	ATPases associated with a variety of cellular activities
SynM161_00374	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynM161_00380	COG3001	Fructosamine kinase
SynM161_00384	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynM161_00385	COG1606	tRNA processing
SynM161_00386	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynM161_00387	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynM161_00390	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynM161_00391	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynM161_00392	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynM161_00395	COG0772	Belongs to the SEDS family
SynM161_00396	COG0489	protein tyrosine kinase activity
SynM161_00397	COG0408	coproporphyrinogen oxidase activity
SynM161_00401	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SynM161_00410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynM161_00412	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynM161_00413	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynM161_00413	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynM161_00414	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynM161_00440	COG0237	dephospho-CoA kinase activity
SynM161_00444	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynM161_00464	COG1070	Carbohydrate kinase
SynM161_00465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynM161_00467	COG0539	negative regulation of cytoplasmic translation
SynM161_00468	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynM161_00473	COG0589	response to stress
SynM161_00476	COG0758	DNA mediated transformation
SynM161_00476	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynM161_00477	COG2890	protein-(glutamine-N5) methyltransferase activity
SynM161_00478	COG0009	L-threonylcarbamoyladenylate synthase
SynM161_00482	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynM161_00483	COG2894	cell division
SynM161_00484	COG0850	regulation of cytokinetic process
SynM161_00485	COG1078	dGTPase activity
SynM161_00486	COG0793	Belongs to the peptidase S41A family
SynM161_00487	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynM161_00488	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynM161_00496	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynM161_00497	COG0235	Class ii aldolase
SynM161_00498	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynM161_00499	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynM161_00502	COG0514	ATP-dependent DNA helicase (RecQ)
SynM161_00504	COG1012	belongs to the aldehyde dehydrogenase family
SynM161_00506	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynM161_00507	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynM161_00511	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynM161_00513	COG0659	secondary active sulfate transmembrane transporter activity
SynM161_00514	COG4243	Vitamin k epoxide reductase
SynM161_00515	COG0484	heat shock protein binding
SynM161_00516	COG0113	porphobilinogen synthase activity
SynM161_00518	COG1193	negative regulation of DNA recombination
SynM161_00519	COG3842	ATPase activity
SynM161_00520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynM161_00524	COG0488	(ABC) transporter
SynM161_00526	COG0435	Glutathione S-transferase
SynM161_00527	COG2988	succinylglutamate desuccinylase activity
SynM161_00552	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynM161_00554	COG1185	polyribonucleotide nucleotidyltransferase activity
SynM161_00555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynM161_00556	COG0750	zinc metalloprotease
SynM161_00557	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynM161_00559	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynM161_00561	COG0706	membrane insertase activity
SynM161_00563	COG0594	ribonuclease P activity
SynM161_00564	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynM161_00567	COG0616	signal peptide processing
SynM161_00568	COG0697	spore germination
SynM161_00570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynM161_00572	COG1842	Phage shock protein A
SynM161_00573	COG3118	belongs to the thioredoxin family
SynM161_00574	COG0436	Aminotransferase
SynM161_00575	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynM161_00575	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynM161_00576	COG0739	heme binding
SynM161_00578	COG1136	(ABC) transporter
SynM161_00578	COG0577	efflux transmembrane transporter activity
SynM161_00579	COG1007	ATP synthesis coupled electron transport
SynM161_00580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynM161_00583	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynM161_00589	COG1845	cytochrome c oxidase, subunit III
SynM161_00591	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynM161_00592	COG1612	heme a metabolic process
SynM161_00593	COG0109	protoheme IX farnesyltransferase activity
SynM161_00597	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynM161_00598	COG0459	protein refolding
SynM161_00600	COG1028	Short-chain dehydrogenase reductase Sdr
SynM161_00603	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynM161_00604	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynM161_00605	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynM161_00606	COG0248	Ppx GppA phosphatase
SynM161_00609	COG2875	Belongs to the precorrin methyltransferase family
SynM161_00610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynM161_00611	COG0739	heme binding
SynM161_00612	COG0723	plastoquinol--plastocyanin reductase activity
SynM161_00614	COG0805	protein transport
SynM161_00615	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynM161_00616	COG0194	GDP metabolic process
SynM161_00619	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynM161_00620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynM161_00621	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynM161_00624	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynM161_00628	COG0335	large ribosomal subunit rRNA binding
SynM161_00630	COG0024	Methionine aminopeptidase
SynM161_00631	COG0300	oxidoreductase activity
SynM161_00631	COG3000	fatty acid hydroxylase
SynM161_00633	COG0857	belongs to the CobB CobQ family
SynM161_00636	COG1666	GTP binding
SynM161_00638	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SynM161_00640	COG0295	cytidine deaminase activity
SynM161_00642	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynM161_00643	COG0277	FAD linked oxidase domain protein
SynM161_00644	COG0708	Exodeoxyribonuclease III
SynM161_00648	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynM161_00649	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynM161_00653	COG3842	ATPase activity
SynM161_00655	COG0523	cobalamin synthesis protein
SynM161_00656	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynM161_00657	COG0432	Pfam Uncharacterised protein family UPF0047
SynM161_00661	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynM161_00663	COG0181	hydroxymethylbilane synthase activity
SynM161_00665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynM161_00666	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynM161_00668	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynM161_00674	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynM161_00675	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynM161_00677	COG0442	prolyl-tRNA aminoacylation
SynM161_00680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynM161_00686	COG0588	phosphoglycerate mutase activity
SynM161_00689	COG0768	penicillin binding
SynM161_00690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynM161_00693	COG0415	Belongs to the DNA photolyase family
SynM161_00695	COG0233	cytoplasmic translational termination
SynM161_00696	COG0528	UMP kinase activity
SynM161_00699	COG2226	methyltransferase
SynM161_00701	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynM161_00702	COG0028	Belongs to the TPP enzyme family
SynM161_00706	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynM161_00709	COG0539	negative regulation of cytoplasmic translation
SynM161_00711	COG3396	Phenylacetate-CoA oxygenase
SynM161_00713	COG5322	oxidoreductase activity
SynM161_00714	COG0825	malonyl-CoA metabolic process
SynM161_00716	COG0302	gtp cyclohydrolase
SynM161_00717	COG0135	phosphoribosylanthranilate isomerase activity
SynM161_00718	COG1994	Peptidase M50
SynM161_00718	COG0517	IMP dehydrogenase activity
SynM161_00719	COG0095	Lipoate-protein ligase
SynM161_00720	COG0730	response to heat
SynM161_00726	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynM161_00727	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynM161_00728	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynM161_00730	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynM161_00731	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynM161_00732	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynM161_00733	COG1850	ribulose-bisphosphate carboxylase activity
SynM161_00734	COG4451	ribulose bisphosphate carboxylase, small
SynM161_00739	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynM161_00740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynM161_00741	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynM161_00747	COG1492	cobalamin metabolic process
SynM161_00749	COG0424	maF-like protein
SynM161_00751	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynM161_00752	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynM161_00754	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynM161_00767	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynM161_00768	COG0579	oxidoreductase
SynM161_00770	COG0481	GTPase activity
SynM161_00771	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SynM161_00774	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynM161_00775	COG3695	enzyme binding
SynM161_00776	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynM161_00776	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynM161_00777	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynM161_00778	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynM161_00780	COG0107	imidazoleglycerol-phosphate synthase activity
SynM161_00781	COG2226	methyltransferase
SynM161_00783	COG0752	glycyl-tRNA synthetase alpha subunit
SynM161_00790	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynM161_00791	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynM161_00792	COG0740	serine-type endopeptidase activity
SynM161_00793	COG0740	serine-type endopeptidase activity
SynM161_00794	COG4956	integral membrane protein (PIN domain superfamily)
SynM161_00795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynM161_00796	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynM161_00797	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynM161_00800	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynM161_00801	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynM161_00807	COG1357	PFAM Pentapeptide repeats (8 copies)
SynM161_00808	COG0285	dihydrofolate synthase activity
SynM161_00809	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynM161_00810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynM161_00811	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynM161_00814	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynM161_00815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynM161_00816	COG0134	indole-3-glycerol-phosphate synthase activity
SynM161_00822	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynM161_00823	COG0482	sulfurtransferase activity
SynM161_00824	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynM161_00824	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynM161_00825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynM161_00826	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynM161_00828	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynM161_00829	COG0228	four-way junction DNA binding
SynM161_00830	COG1702	phosphate starvation-inducible protein PhoH
SynM161_00831	COG0670	Belongs to the BI1 family
SynM161_00833	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynM161_00835	COG0336	Belongs to the RNA methyltransferase TrmD family
SynM161_00837	COG1691	(AIR) carboxylase
SynM161_00841	COG0352	thiamine-phosphate diphosphorylase activity
SynM161_00843	COG0196	riboflavin kinase activity
SynM161_00845	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynM161_00846	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynM161_00847	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynM161_00857	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynM161_00857	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynM161_00859	COG2135	peptidase activity
SynM161_00860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynM161_00861	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynM161_00864	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynM161_00924	COG0251	oxidation-reduction process
SynM161_00925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynM161_00926	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynM161_00927	COG1132	(ABC) transporter
SynM161_00928	COG0456	acetyltransferase
SynM161_00931	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynM161_00932	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynM161_00936	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynM161_00939	COG0659	secondary active sulfate transmembrane transporter activity
SynM161_00940	COG0418	dihydroorotase activity
SynM161_00945	COG0159	tryptophan synthase activity
SynM161_00948	COG2010	Cytochrome c
SynM161_00955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynM161_00959	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynM161_00959	COG0140	phosphoribosyl-ATP diphosphatase activity
SynM161_00961	COG0542	response to heat
SynM161_00968	COG3794	PFAM blue (type 1) copper domain protein
SynM161_00970	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynM161_00971	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynM161_00979	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynM161_00982	COG0339	signal peptide processing
SynM161_00983	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynM161_00984	COG0083	homoserine kinase activity
SynM161_00985	COG0837	glucose binding
SynM161_00987	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynM161_00991	COG0180	Tryptophanyl-tRNA synthetase
SynM161_01020	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynM161_01045	COG0484	heat shock protein binding
SynM161_01057	COG0189	ligase activity
SynM161_01057	COG4067	protein conserved in archaea
SynM161_01064	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynM161_01073	COG0681	Belongs to the peptidase S26 family
SynM161_01074	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynM161_01075	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynM161_01077	COG1376	ErfK ybiS ycfS ynhG family protein
SynM161_01078	COG0297	glycogen (starch) synthase activity
SynM161_01080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynM161_01081	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynM161_01083	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynM161_01084	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynM161_01085	COG2045	Belongs to the ComB family
SynM161_01088	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynM161_01089	COG0142	geranyltranstransferase activity
SynM161_01090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynM161_01091	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynM161_01093	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynM161_01094	COG2176	DNA-directed DNA polymerase activity
SynM161_01096	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynM161_01097	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynM161_01098	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynM161_01103	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynM161_01106	COG1132	(ABC) transporter
SynM161_01107	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynM161_01108	COG0505	Belongs to the CarA family
SynM161_01110	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynM161_01111	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynM161_01113	COG0154	amidase activity
SynM161_01114	COG0587	DNA-directed DNA polymerase activity
SynM161_01116	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynM161_01117	COG0632	four-way junction helicase activity
SynM161_01120	COG0358	DNA primase activity
SynM161_01124	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynM161_01128	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynM161_01132	COG0792	nuclease activity
SynM161_01133	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynM161_01134	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynM161_01137	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynM161_01137	COG0022	dehydrogenase e1 component
SynM161_01138	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynM161_01139	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynM161_01144	COG0628	permease
SynM161_01146	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynM161_01147	COG0515	serine threonine protein kinase
SynM161_01152	COG2226	methyltransferase
SynM161_01153	COG0174	glutamine synthetase
SynM161_01155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynM161_01159	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynM161_01163	COG0612	Peptidase, M16
SynM161_01169	COG1216	Glycosyl transferase, family 2
SynM161_01170	COG0052	Belongs to the universal ribosomal protein uS2 family
SynM161_01171	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynM161_01173	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynM161_01174	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynM161_01175	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynM161_01176	COG0751	glycine-tRNA ligase activity
SynM161_01178	COG0644	oxidoreductase
SynM161_01180	COG0826	peptidase U32
SynM161_01181	COG1217	gtp-binding protein TYPA
SynM161_01186	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynM161_01189	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynM161_01190	COG1494	fructose-1,6-bisphosphatase
SynM161_01191	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynM161_01192	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynM161_01193	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynM161_01194	COG0363	glucosamine-6-phosphate deaminase activity
SynM161_01197	COG0129	dihydroxy-acid dehydratase activity
SynM161_01199	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynM161_01200	COG1357	PFAM Pentapeptide repeats (8 copies)
SynM161_01208	COG0300	oxidoreductase activity
SynM161_01218	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynM161_01221	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynM161_01222	COG1122	ATPase activity
SynM161_01226	COG1836	PFAM Integral membrane protein DUF92
SynM161_01233	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynM161_01234	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynM161_01235	COG0436	Aminotransferase
SynM161_01237	COG1573	uracil-dna glycosylase
SynM161_01238	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynM161_01239	COG0793	Belongs to the peptidase S41A family
SynM161_01241	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynM161_01247	COG0861	Integral membrane protein TerC family
SynM161_01250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynM161_01252	COG0312	modulator of DNA gyrase
SynM161_01253	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynM161_01256	COG0163	prenyltransferase activity
SynM161_01257	COG0557	exoribonuclease II activity
SynM161_01259	COG2119	membrane
SynM161_01262	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynM161_01262	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynM161_01263	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynM161_01266	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynM161_01267	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynM161_01268	COG1615	UPF0182 protein
SynM161_01269	COG0450	alkyl hydroperoxide reductase
SynM161_01272	COG0739	heme binding
SynM161_01273	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynM161_01279	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynM161_01281	COG0557	exoribonuclease II activity
SynM161_01282	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynM161_01283	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynM161_01284	COG0072	phenylalanine-tRNA ligase activity
SynM161_01285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynM161_01291	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynM161_01294	COG2385	sporulation resulting in formation of a cellular spore
SynM161_01299	COG0646	methionine synthase
SynM161_01299	COG1410	methionine synthase
SynM161_01300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynM161_01304	COG1981	membrane
SynM161_01305	COG3046	protein related to deoxyribodipyrimidine photolyase
SynM161_01307	COG0322	excinuclease ABC activity
SynM161_01309	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynM161_01311	COG2027	D-alanyl-D-alanine carboxypeptidase
SynM161_01314	COG1104	cysteine desulfurase activity
SynM161_01315	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynM161_01317	COG0495	leucyl-tRNA aminoacylation
SynM161_01318	COG0166	Belongs to the GPI family
SynM161_01325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynM161_01326	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynM161_01327	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynM161_01327	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynM161_01328	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynM161_01329	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynM161_01330	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynM161_01332	COG0484	heat shock protein binding
SynM161_01333	COG0443	Heat shock 70 kDa protein
SynM161_01334	COG0573	inorganic phosphate transmembrane transporter activity
SynM161_01335	COG0581	inorganic phosphate transmembrane transporter activity
SynM161_01336	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynM161_01339	COG0483	inositol monophosphate 1-phosphatase activity
SynM161_01340	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynM161_01342	COG0326	Molecular chaperone. Has ATPase activity
SynM161_01343	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynM161_01344	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynM161_01345	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynM161_01346	COG1653	transport
SynM161_01347	COG1175	transmembrane transport
SynM161_01354	COG0446	pyridine nucleotide-disulphide oxidoreductase
SynM161_01355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynM161_01356	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynM161_01358	COG0762	integral membrane protein
SynM161_01361	COG0469	pyruvate kinase activity
SynM161_01362	COG0577	efflux transmembrane transporter activity
SynM161_01362	COG1136	(ABC) transporter
SynM161_01363	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynM161_01365	COG0740	serine-type endopeptidase activity
SynM161_01370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynM161_01377	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynM161_01378	COG1175	transmembrane transport
SynM161_01379	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynM161_01386	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SynM161_01391	COG1793	dna ligase
SynM161_01392	COG1201	RNA secondary structure unwinding
SynM161_01412	COG2226	methyltransferase
SynM161_01422	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynM161_01424	COG1121	(ABC) transporter
SynM161_01425	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynM161_01426	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynM161_01427	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynM161_01431	COG0572	uridine kinase
SynM161_01451	COG2032	superoxide dismutase activity
SynM161_01455	COG0724	RNA recognition motif
SynM161_01457	COG0463	Glycosyl transferase, family 2
SynM161_01477	COG2124	cytochrome p450
SynM161_01482	COG0237	dephospho-CoA kinase activity
SynM161_01495	COG1611	Belongs to the LOG family
SynM161_01496	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SynM161_01514	COG0590	tRNA wobble adenosine to inosine editing
SynM161_01538	COG0405	Gamma-glutamyltransferase
SynM161_01544	COG2197	response regulator
SynM161_01558	COG3659	wide pore channel activity
SynM161_01560	COG3128	pkhd-type hydroxylase
SynM161_01561	COG1840	ABC-type Fe3 transport system, periplasmic component
SynM161_01563	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynM161_01565	COG3659	wide pore channel activity
SynM161_01574	COG0701	Predicted permease
SynM161_01579	COG1121	(ABC) transporter
SynM161_01580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynM161_01585	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynM161_01589	COG1640	4-alpha-glucanotransferase
SynM161_01590	COG1187	pseudouridine synthase activity
SynM161_01591	COG5002	protein histidine kinase activity
SynM161_01592	COG0745	RESPONSE REGULATOR receiver
SynM161_01594	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynM161_01595	COG1982	Orn Lys Arg decarboxylase major
SynM161_01596	COG0575	Belongs to the CDS family
SynM161_01598	COG2267	carboxylic ester hydrolase activity
SynM161_01599	COG0371	Dehydrogenase
SynM161_01600	COG0542	response to heat
SynM161_01602	COG0019	diaminopimelate decarboxylase activity
SynM161_01603	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynM161_01604	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynM161_01605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynM161_01607	COG1054	Belongs to the UPF0176 family
SynM161_01608	COG0625	glutathione transferase activity
SynM161_01610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynM161_01611	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynM161_01614	COG0589	response to stress
SynM161_01614	COG0475	glutathione-regulated potassium exporter activity
SynM161_01615	COG1132	(ABC) transporter
SynM161_01617	COG0724	RNA recognition motif
SynM161_01620	COG0513	Belongs to the DEAD box helicase family
SynM161_01622	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynM161_01625	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynM161_01629	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynM161_01632	COG0271	Belongs to the BolA IbaG family
SynM161_01633	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynM161_01635	COG0745	RESPONSE REGULATOR receiver
SynM161_01643	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynM161_01645	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynM161_01676	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynM161_01685	COG0735	belongs to the Fur family
SynM161_01701	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynM161_01708	COG1126	abc transporter atp-binding protein
SynM161_01709	COG0765	amino acid transport
SynM161_01710	COG4597	amino acid ABC transporter
SynM161_01711	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynM161_01713	COG0659	secondary active sulfate transmembrane transporter activity
SynM161_01722	COG0799	negative regulation of ribosome biogenesis
SynM161_01724	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynM161_01726	COG1115	amino acid carrier protein
SynM161_01728	COG1132	(ABC) transporter
SynM161_01730	COG0149	triose-phosphate isomerase activity
SynM161_01731	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynM161_01733	COG1429	ligase activity, forming nitrogen-metal bonds
SynM161_01734	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynM161_01736	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynM161_01739	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynM161_01748	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynM161_01749	COG0640	Transcriptional regulator
SynM161_01751	COG0668	transmembrane transport
SynM161_01754	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynM161_01755	COG0047	phosphoribosylformylglycinamidine synthase activity
SynM161_01756	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynM161_01757	COG0191	fructose-bisphosphate aldolase activity
SynM161_01758	COG0673	inositol 2-dehydrogenase activity
SynM161_01760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynM161_01761	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynM161_01763	COG3954	Phosphoribulokinase
SynM161_01764	COG0473	3-isopropylmalate dehydrogenase activity
SynM161_01765	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynM161_01766	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynM161_01769	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynM161_01772	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynM161_01773	COG2197	response regulator
SynM161_01775	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynM161_01783	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynM161_01799	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynM161_01801	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynM161_01813	COG0308	aminopeptidase N
SynM161_01818	COG2205	protein histidine kinase activity
SynM161_01823	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynM161_01825	COG1797	cobyrinic acid a,c-diamide synthase activity
SynM161_01826	COG1254	Belongs to the acylphosphatase family
SynM161_01828	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynM161_01833	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynM161_01834	COG1480	7TM receptor with intracellular HD hydrolase
SynM161_01835	COG0564	pseudouridine synthase activity
SynM161_01837	COG0011	TIGRFAM Protein of
SynM161_01842	COG0395	ABC-type sugar transport system, permease component
SynM161_01843	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynM161_01844	COG1543	Belongs to the glycosyl hydrolase 57 family
SynM161_01845	COG0644	oxidoreductase
SynM161_01846	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynM161_01847	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynM161_01848	COG0516	GMP reductase activity
SynM161_01849	COG3118	belongs to the thioredoxin family
SynM161_01850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynM161_01851	COG0742	ribosomal rna small subunit methyltransferase
SynM161_01852	COG2010	Cytochrome c
SynM161_01853	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SynM161_01856	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynM161_01857	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynM161_01858	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynM161_01860	COG2166	iron-sulfur cluster assembly
SynM161_01861	COG0460	homoserine dehydrogenase
SynM161_01863	COG0747	negative chemotaxis
SynM161_01864	COG0601	transmembrane transport
SynM161_01869	COG0012	GTP binding
SynM161_01870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynM161_01871	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynM161_01871	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynM161_01872	COG0215	cysteine-tRNA ligase activity
SynM161_01874	COG0733	neurotransmitter:sodium symporter activity
SynM161_01875	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynM161_01876	COG3411	Ferredoxin
SynM161_01886	COG0492	ferredoxin-NADP+ reductase activity
SynM161_01887	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynM161_01893	COG2267	carboxylic ester hydrolase activity
SynM161_01894	COG0440	acetolactate synthase activity
SynM161_01895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynM161_01901	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynM161_01902	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynM161_01903	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynM161_01905	COG1022	Amp-dependent synthetase and ligase
SynM161_01906	COG0321	lipoyl(octanoyl) transferase activity
SynM161_01907	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynM161_01909	COG1381	Involved in DNA repair and RecF pathway recombination
SynM161_01911	COG0438	transferase activity, transferring glycosyl groups
SynM161_01915	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynM161_01917	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynM161_01918	COG1799	cell septum assembly
SynM161_01919	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynM161_01921	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynM161_01922	COG1160	GTP binding
SynM161_01923	COG1376	ErfK ybiS ycfS ynhG family protein
SynM161_01925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynM161_01928	COG1091	dTDP-4-dehydrorhamnose reductase activity
SynM161_01929	COG1088	dTDP-glucose 4,6-dehydratase activity
SynM161_01930	COG0114	fumarate hydratase activity
SynM161_01931	COG4581	dead DEAH box helicase
SynM161_01933	COG0385	Bile acid
SynM161_01934	COG0156	8-amino-7-oxononanoate synthase activity
SynM161_01937	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynM161_01940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynM161_01943	COG0357	Ribosomal RNA small subunit methyltransferase G
SynM161_01951	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynM161_01952	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynM161_01953	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynM161_01954	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynM161_01955	COG0085	RNA polymerase activity
SynM161_01956	COG0084	hydrolase, TatD family'
SynM161_01957	COG0268	Binds directly to 16S ribosomal RNA
SynM161_01958	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynM161_01959	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynM161_01960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynM161_01961	COG0641	radical SAM
SynM161_01963	COG0779	Required for maturation of 30S ribosomal subunits
SynM161_01964	COG0195	Participates in both transcription termination and antitermination
SynM161_01966	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynM161_01971	COG1053	succinate dehydrogenase
SynM161_01977	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynM161_01978	COG0776	regulation of translation
SynM161_01982	COG2211	Major facilitator Superfamily
SynM161_01983	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynM161_01986	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynM161_01987	COG0284	orotidine-5'-phosphate decarboxylase activity
SynM161_01988	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynM161_01993	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynM161_02002	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynM161_02004	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynM161_02005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynM161_02006	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynM161_02008	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynM161_02010	COG0151	Belongs to the GarS family
SynM161_02011	COG5002	protein histidine kinase activity
SynM161_02012	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynM161_02013	COG4251	negative regulation of phosphorylation
SynM161_02015	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynM161_02016	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynM161_02018	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynM161_02019	COG0217	transcriptional regulatory protein
SynM161_02022	COG0363	glucosamine-6-phosphate deaminase activity
SynM161_02023	COG2247	cell wall binding repeat
SynM161_02023	COG2385	sporulation resulting in formation of a cellular spore
SynM161_02024	COG1234	tRNA 3'-trailer cleavage
SynM161_02025	COG2010	Cytochrome c
SynM161_02028	COG2264	protein methyltransferase activity
SynM161_02029	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynM161_02033	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynM161_02040	COG0443	Heat shock 70 kDa protein
SynM161_02043	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynM161_02044	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynM161_02048	COG0459	protein refolding
SynM161_02049	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynM161_02051	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynM161_02052	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynM161_02055	COG0006	proline dipeptidase activity
SynM161_02056	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynM161_02057	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynM161_02058	COG1253	flavin adenine dinucleotide binding
SynM161_02059	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynM161_02060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynM161_02061	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynM161_02061	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynM161_02062	COG0686	Belongs to the AlaDH PNT family
SynM161_02063	COG3012	SEC-C Motif Domain Protein
SynM161_02064	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynM161_02066	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynM161_02068	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynM161_02069	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynM161_02070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynM161_02071	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynM161_02072	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynM161_02073	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynM161_02074	COG0356	it plays a direct role in the translocation of protons across the membrane
SynM161_02076	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynM161_02077	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynM161_02083	COG0772	Belongs to the SEDS family
SynM161_02086	COG1333	cytochrome c biogenesis protein
SynM161_02088	COG2337	Toxic component of a toxin-antitoxin (TA) module
SynM161_02089	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynM161_02093	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynM161_02099	COG1132	(ABC) transporter
SynM161_02104	COG1083	cytidylyl-transferase
SynM161_02105	COG2089	acid synthase
SynM161_02122	COG0438	transferase activity, transferring glycosyl groups
SynM161_02125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynM161_02137	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynM161_02141	COG0277	FAD linked oxidase domain protein
SynM161_02156	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SynM161_02157	COG0116	Belongs to the methyltransferase superfamily
SynM161_02161	COG1196	nuclear chromosome segregation
SynM161_02163	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynM161_02167	COG0439	Biotin carboxylase
SynM161_02170	COG0515	serine threonine protein kinase
SynM161_02173	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynM161_02174	COG4178	(ABC) transporter
SynM161_02175	COG0537	adenosine 5'-monophosphoramidase activity
SynM161_02180	COG0242	peptide deformylase activity
SynM161_02183	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynM161_02184	COG0719	Fe-S assembly protein
SynM161_02185	COG0396	ATPase activity
SynM161_02186	COG0719	Fe-S assembly protein
SynM161_02187	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynM161_02191	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynM161_02195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SynM161_02196	COG0457	Tetratricopeptide repeat
SynM161_02202	COG0033	Phosphoglucomutase
SynM161_02204	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynM161_02206	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SynM161_02210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynM161_02211	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynM161_02212	COG0175	sulfate reduction
SynM161_02213	COG1252	NADH dehydrogenase
SynM161_02214	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynM161_02215	COG3273	potassium ion transport
SynM161_02215	COG0471	metal ion transport
SynM161_02216	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynM161_02217	COG0569	domain protein
SynM161_02218	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynM161_02223	COG0488	(ABC) transporter
SynM161_02225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynM161_02229	COG1643	Atp-dependent helicase
SynM161_02232	COG1570	exodeoxyribonuclease VII activity
SynM161_02246	COG1968	undecaprenyl-diphosphatase activity
SynM161_02248	COG1555	photosystem II stabilization
SynM161_02249	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynM161_02250	COG4243	Vitamin k epoxide reductase
SynM161_02251	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynM161_02253	COG1032	radical SAM domain protein
SynM161_02253	COG1032	radical SAM domain protein
SynM161_02258	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynM161_02263	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynM161_02264	COG1472	Belongs to the glycosyl hydrolase 3 family
SynM161_02265	COG0463	Glycosyl transferase, family 2
SynM161_02265	COG0457	Tetratricopeptide repeat
SynM161_02266	COG1587	Uroporphyrinogen-III synthase
SynM161_02270	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynM161_02271	COG0316	Belongs to the HesB IscA family
SynM161_02275	COG1090	epimerase
SynM161_02278	COG0484	heat shock protein binding
SynM161_02279	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynM161_02280	COG3659	wide pore channel activity
SynM161_02281	COG3659	wide pore channel activity
SynM161_02292	COG1122	ATPase activity
SynM161_02294	COG0745	RESPONSE REGULATOR receiver
SynM161_02296	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynM161_02297	COG2217	Heavy metal translocating P-type atpase
SynM161_02298	COG3063	Type IV pilus biogenesis stability protein PilW
SynM161_02299	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynM161_02301	COG0416	fatty acid biosynthetic process
SynM161_02302	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynM161_02303	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynM161_02304	COG0204	Acyl-transferase
SynM161_02304	COG0318	PFAM AMP-dependent synthetase and ligase
SynM161_02306	COG1214	PFAM Peptidase M22, glycoprotease
SynM161_02308	COG0617	tRNA 3'-terminal CCA addition
SynM161_02309	COG0724	RNA recognition motif
SynM161_02310	COG1562	ergosterol biosynthetic process
SynM161_02311	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynM161_02311	COG0493	'glutamate synthase
SynM161_02314	COG0583	DNA-binding transcription factor activity
SynM161_02316	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynM161_02317	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynM161_02320	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynM161_02322	COG2197	response regulator
SynM161_02325	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynM161_02326	COG0713	ATP synthesis coupled electron transport
SynM161_02327	COG0839	Belongs to the complex I subunit 6 family
SynM161_02328	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynM161_02329	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynM161_02330	COG0372	Belongs to the citrate synthase family
SynM161_02333	COG1054	Belongs to the UPF0176 family
SynM161_02334	COG1420	regulation of RNA biosynthetic process
SynM161_02335	COG0133	tryptophan synthase activity
SynM161_02336	COG0023	Translation Initiation Factor
SynM161_02337	COG0529	Catalyzes the synthesis of activated sulfate
SynM161_02338	COG0628	permease
SynM161_02340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynM161_02342	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynM161_02343	COG0564	pseudouridine synthase activity
SynM161_02344	COG0745	RESPONSE REGULATOR receiver
SynM161_02346	COG1104	cysteine desulfurase activity
SynM161_02347	COG0275	rRNA processing
SynM161_02348	COG0649	NAD binding
SynM161_02351	COG0824	Thioesterase
SynM161_02354	COG1575	Belongs to the MenA family. Type 1 subfamily
SynM161_02356	COG0189	ligase activity
SynM161_02357	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynM161_02358	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynM161_02360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynM161_02361	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynM161_02364	COG0252	asparaginase activity
SynM161_02365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynM161_02366	COG0018	arginyl-trna synthetase
SynM161_02367	COG0157	Belongs to the NadC ModD family
SynM161_02368	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynM161_02370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynM161_02371	COG4172	Belongs to the ABC transporter superfamily
SynM161_02372	COG0564	pseudouridine synthase activity
SynM161_02373	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SynM161_02374	COG0126	phosphoglycerate kinase activity
SynM161_02377	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynM161_02382	COG0167	dihydroorotate dehydrogenase activity
SynM161_02383	COG0328	RNA-DNA hybrid ribonuclease activity
SynM161_02385	COG0222	ribosome binding
SynM161_02386	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynM161_02387	COG0081	regulation of translation
SynM161_02388	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynM161_02389	COG0250	Participates in transcription elongation, termination and antitermination
SynM161_02390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynM161_02391	COG0542	response to heat
SynM161_02392	COG0346	lactoylglutathione lyase activity
SynM161_02393	COG0148	phosphopyruvate hydratase activity
SynM161_02394	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynM161_02398	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynM161_02399	COG0237	dephospho-CoA kinase activity
SynM161_02401	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynM161_02402	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynM161_02402	COG2022	thiamine diphosphate biosynthetic process
SynM161_02403	COG0105	UTP biosynthetic process
SynM161_02404	COG1166	arginine decarboxylase activity
SynM161_02405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynM161_02407	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynM161_02413	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynM161_02413	COG0426	domain, Protein
SynM161_02414	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynM161_02414	COG0426	domain, Protein
SynM161_02415	COG1773	rubredoxin
SynM161_02417	COG1741	Belongs to the pirin family
SynM161_02420	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynM161_02420	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynM161_02421	COG0509	glycine decarboxylation via glycine cleavage system
SynM161_02422	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynM161_02424	COG0359	binds to the 23S rRNA
SynM161_02425	COG0305	Participates in initiation and elongation during chromosome replication
SynM161_02425	COG0305	Participates in initiation and elongation during chromosome replication
SynM161_02425	COG1372	Participates in initiation and elongation during chromosome replication
SynM161_02425	COG1372	Participates in initiation and elongation during chromosome replication
SynM161_02426	COG0445	tRNA wobble uridine modification
SynM161_02433	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynM161_02435	COG0398	Pfam SNARE associated Golgi protein
SynM161_02439	COG0525	valine-tRNA ligase activity
SynM161_02444	COG4221	oxidoreductase activity
SynM161_02445	COG0735	belongs to the Fur family
SynM161_02454	COG3956	TIGRFAM MazG family protein
SynM161_02455	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynM161_02457	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynM161_02458	COG0010	Belongs to the arginase family
SynM161_02461	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynM161_02462	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynM161_02463	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynM161_02464	COG0504	CTP synthase activity
SynM161_02465	COG0602	queuosine metabolic process
SynM161_02467	COG2084	Dehydrogenase
SynM161_02468	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynM161_02472	COG0366	Alpha amylase catalytic
SynM161_02473	COG0463	Glycosyl transferase, family 2
SynM161_02481	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynM161_02482	COG0830	nickel cation binding
SynM161_02483	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynM161_02484	COG0829	nickel cation binding
SynM161_02485	COG0831	urea catabolic process
SynM161_02486	COG0832	Belongs to the urease beta subunit family
SynM161_02487	COG0804	urea catabolic process
SynM161_02488	COG0519	Catalyzes the synthesis of GMP from XMP
SynM161_02488	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynM161_02493	COG0367	asparagine synthase
SynM161_02494	COG0540	Belongs to the ATCase OTCase family
SynM161_02498	COG2308	Evidence 4 Homologs of previously reported genes of
SynM161_02502	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynM161_02503	COG0746	molybdenum cofactor guanylyltransferase activity
SynM161_02504	COG2223	nitrite transmembrane transporter activity
SynM161_02505	COG0243	molybdopterin cofactor binding
SynM161_02510	COG0315	cyclic pyranopterin monophosphate synthase activity
SynM161_02511	COG0303	'Molybdopterin
SynM161_02514	COG0314	molybdopterin synthase activity
SynM161_02516	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynM161_02517	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynM161_02520	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynM161_02522	COG2116	formate transmembrane transporter activity
SynM161_02524	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynM161_02526	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynM161_02529	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynM161_02530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynM161_02531	COG0170	dolichyl monophosphate biosynthetic process
SynM161_02532	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynM161_02533	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynM161_02537	COG0788	formyltetrahydrofolate deformylase activity
SynM161_02540	COG0443	Heat shock 70 kDa protein
SynM161_02541	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynM161_02543	COG0360	Binds together with S18 to 16S ribosomal RNA
SynM161_02545	COG0137	argininosuccinate synthase activity
SynM161_02548	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynM161_02551	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynM161_02552	COG0438	transferase activity, transferring glycosyl groups
SynM161_02555	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynM161_02556	COG0497	DNA recombination
SynM161_02557	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynM161_02559	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine