locus-tag	class	description
SynMEDNS5_00001	COG0592	DNA-directed DNA polymerase activity
SynMEDNS5_00003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynMEDNS5_00004	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynMEDNS5_00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynMEDNS5_00007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynMEDNS5_00010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynMEDNS5_00011	COG0552	protein localization to endoplasmic reticulum
SynMEDNS5_00012	COG2208	phosphoserine phosphatase activity
SynMEDNS5_00013	COG0165	Argininosuccinate lyase
SynMEDNS5_00014	COG0724	RNA recognition motif
SynMEDNS5_00015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynMEDNS5_00017	COG2081	HI0933 family
SynMEDNS5_00018	COG1459	type II secretion system
SynMEDNS5_00020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynMEDNS5_00021	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynMEDNS5_00022	COG0484	heat shock protein binding
SynMEDNS5_00024	COG1162	GTPase activity
SynMEDNS5_00025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynMEDNS5_00026	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynMEDNS5_00027	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynMEDNS5_00028	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynMEDNS5_00029	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynMEDNS5_00030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynMEDNS5_00031	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynMEDNS5_00032	COG0511	ligase activity, forming carbon-carbon bonds
SynMEDNS5_00033	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynMEDNS5_00049	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynMEDNS5_00050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynMEDNS5_00050	COG0519	Catalyzes the synthesis of GMP from XMP
SynMEDNS5_00053	COG0768	penicillin binding
SynMEDNS5_00054	COG0438	transferase activity, transferring glycosyl groups
SynMEDNS5_00055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynMEDNS5_00057	COG2022	thiamine diphosphate biosynthetic process
SynMEDNS5_00060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynMEDNS5_00061	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynMEDNS5_00062	COG2385	sporulation resulting in formation of a cellular spore
SynMEDNS5_00063	COG1215	transferase activity, transferring glycosyl groups
SynMEDNS5_00064	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynMEDNS5_00066	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynMEDNS5_00067	COG0740	serine-type endopeptidase activity
SynMEDNS5_00068	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynMEDNS5_00069	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynMEDNS5_00070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynMEDNS5_00071	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynMEDNS5_00073	COG0037	tRNA processing
SynMEDNS5_00076	COG0556	nucleotide-excision repair
SynMEDNS5_00080	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynMEDNS5_00082	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynMEDNS5_00085	COG0438	transferase activity, transferring glycosyl groups
SynMEDNS5_00086	COG0653	protein targeting
SynMEDNS5_00087	COG1045	serine acetyltransferase
SynMEDNS5_00088	COG1725	Transcriptional regulator
SynMEDNS5_00090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynMEDNS5_00091	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynMEDNS5_00092	COG0187	DNA topoisomerase II activity
SynMEDNS5_00092	COG1372	Participates in initiation and elongation during chromosome replication
SynMEDNS5_00094	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynMEDNS5_00095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynMEDNS5_00096	COG0386	Belongs to the glutathione peroxidase family
SynMEDNS5_00097	COG2239	Acts as a magnesium transporter
SynMEDNS5_00098	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMEDNS5_00102	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynMEDNS5_00107	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynMEDNS5_00108	COG1070	Carbohydrate kinase
SynMEDNS5_00110	COG0802	atpase or kinase
SynMEDNS5_00111	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynMEDNS5_00112	COG0586	Pfam SNARE associated Golgi protein
SynMEDNS5_00113	COG0629	single-stranded DNA binding
SynMEDNS5_00115	COG1792	Involved in formation and maintenance of cell shape
SynMEDNS5_00118	COG0745	RESPONSE REGULATOR receiver
SynMEDNS5_00119	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynMEDNS5_00123	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynMEDNS5_00124	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynMEDNS5_00125	COG0515	serine threonine protein kinase
SynMEDNS5_00125	COG1357	PFAM Pentapeptide repeats (8 copies)
SynMEDNS5_00126	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynMEDNS5_00127	COG2255	four-way junction helicase activity
SynMEDNS5_00129	COG1473	amidohydrolase
SynMEDNS5_00132	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynMEDNS5_00134	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynMEDNS5_00135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynMEDNS5_00136	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynMEDNS5_00137	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMEDNS5_00138	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynMEDNS5_00139	COG0662	Cupin 2, conserved barrel domain protein
SynMEDNS5_00139	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynMEDNS5_00140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynMEDNS5_00142	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMEDNS5_00143	COG0571	ribonuclease III activity
SynMEDNS5_00147	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SynMEDNS5_00148	COG0058	SHG alpha-glucan phosphorylase activity
SynMEDNS5_00149	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SynMEDNS5_00150	COG0475	glutathione-regulated potassium exporter activity
SynMEDNS5_00154	COG0277	FAD linked oxidase domain protein
SynMEDNS5_00156	COG0247	lactate metabolic process
SynMEDNS5_00157	COG0538	isocitrate dehydrogenase activity
SynMEDNS5_00158	COG0463	Glycosyl transferase, family 2
SynMEDNS5_00162	COG5398	heme oxygenase
SynMEDNS5_00165	COG0438	transferase activity, transferring glycosyl groups
SynMEDNS5_00166	COG0438	transferase activity, transferring glycosyl groups
SynMEDNS5_00167	COG0438	transferase activity, transferring glycosyl groups
SynMEDNS5_00168	COG0438	transferase activity, transferring glycosyl groups
SynMEDNS5_00172	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynMEDNS5_00174	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynMEDNS5_00176	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynMEDNS5_00177	COG0517	IMP dehydrogenase activity
SynMEDNS5_00177	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SynMEDNS5_00180	COG0517	IMP dehydrogenase activity
SynMEDNS5_00180	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SynMEDNS5_00180	COG0617	tRNA 3'-terminal CCA addition
SynMEDNS5_00189	COG0709	Synthesizes selenophosphate from selenide and ATP
SynMEDNS5_00192	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynMEDNS5_00195	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynMEDNS5_00196	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynMEDNS5_00198	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynMEDNS5_00203	COG0438	transferase activity, transferring glycosyl groups
SynMEDNS5_00210	COG1132	(ABC) transporter
SynMEDNS5_00214	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynMEDNS5_00218	COG2337	Toxic component of a toxin-antitoxin (TA) module
SynMEDNS5_00224	COG1088	dTDP-glucose 4,6-dehydratase activity
SynMEDNS5_00243	COG0124	histidyl-tRNA synthetase
SynMEDNS5_00245	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynMEDNS5_00252	COG4447	cellulose binding
SynMEDNS5_00253	COG1773	rubredoxin
SynMEDNS5_00254	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMEDNS5_00255	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMEDNS5_00256	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMEDNS5_00257	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynMEDNS5_00258	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SynMEDNS5_00260	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynMEDNS5_00260	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynMEDNS5_00262	COG0494	nUDIX hydrolase
SynMEDNS5_00263	COG0415	Belongs to the DNA photolyase family
SynMEDNS5_00269	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynMEDNS5_00270	COG0131	Imidazoleglycerol-phosphate dehydratase
SynMEDNS5_00271	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynMEDNS5_00273	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynMEDNS5_00277	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynMEDNS5_00278	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynMEDNS5_00280	COG0354	folic acid binding
SynMEDNS5_00281	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynMEDNS5_00284	COG1253	flavin adenine dinucleotide binding
SynMEDNS5_00290	COG0343	queuine tRNA-ribosyltransferase activity
SynMEDNS5_00291	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SynMEDNS5_00296	COG0138	bifunctional purine biosynthesis protein purh
SynMEDNS5_00299	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynMEDNS5_00300	COG0004	ammonium transporteR
SynMEDNS5_00301	COG1489	DNA binding
SynMEDNS5_00302	COG0728	peptidoglycan biosynthetic process
SynMEDNS5_00307	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynMEDNS5_00308	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynMEDNS5_00309	COG1058	Belongs to the CinA family
SynMEDNS5_00309	COG1546	Belongs to the CinA family
SynMEDNS5_00310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynMEDNS5_00311	COG0066	3-isopropylmalate dehydratase activity
SynMEDNS5_00319	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynMEDNS5_00320	COG0193	aminoacyl-tRNA hydrolase activity
SynMEDNS5_00323	COG4372	Transposase
SynMEDNS5_00324	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMEDNS5_00325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynMEDNS5_00327	COG0717	Belongs to the dCTP deaminase family
SynMEDNS5_00329	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynMEDNS5_00333	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynMEDNS5_00336	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynMEDNS5_00340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynMEDNS5_00344	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynMEDNS5_00347	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynMEDNS5_00348	COG2094	Belongs to the DNA glycosylase MPG family
SynMEDNS5_00349	COG0540	Belongs to the ATCase OTCase family
SynMEDNS5_00358	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynMEDNS5_00361	COG2046	Belongs to the sulfate adenylyltransferase family
SynMEDNS5_00361	COG0529	Catalyzes the synthesis of activated sulfate
SynMEDNS5_00362	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMEDNS5_00363	COG0800	Aldolase
SynMEDNS5_00365	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynMEDNS5_00367	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynMEDNS5_00368	COG2226	methyltransferase
SynMEDNS5_00369	COG4175	Glycine betaine
SynMEDNS5_00370	COG4176	ABC-type proline glycine betaine transport system permease component
SynMEDNS5_00371	COG2113	Glycine betaine
SynMEDNS5_00372	COG0701	Predicted permease
SynMEDNS5_00373	COG0385	Bile acid
SynMEDNS5_00375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynMEDNS5_00377	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynMEDNS5_00378	COG0436	Aminotransferase
SynMEDNS5_00381	COG1530	ribonuclease E activity
SynMEDNS5_00382	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynMEDNS5_00384	COG1605	Chorismate mutase
SynMEDNS5_00384	COG0077	Prephenate dehydratase
SynMEDNS5_00385	COG2226	methyltransferase
SynMEDNS5_00386	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynMEDNS5_00387	COG0051	transcription antitermination factor activity, RNA binding
SynMEDNS5_00388	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynMEDNS5_00389	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynMEDNS5_00390	COG0049	tRNA binding
SynMEDNS5_00391	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynMEDNS5_00394	COG0067	glutamate synthase
SynMEDNS5_00394	COG0069	glutamate synthase activity
SynMEDNS5_00394	COG0070	glutamate synthase
SynMEDNS5_00396	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynMEDNS5_00401	COG2885	chlorophyll binding
SynMEDNS5_00402	COG2885	chlorophyll binding
SynMEDNS5_00409	COG0463	Glycosyl transferase, family 2
SynMEDNS5_00413	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynMEDNS5_00415	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynMEDNS5_00416	COG0254	rRNA binding
SynMEDNS5_00417	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynMEDNS5_00418	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynMEDNS5_00419	COG0101	tRNA pseudouridine synthase activity
SynMEDNS5_00420	COG0203	ribosomal protein L17
SynMEDNS5_00421	COG0202	RNA polymerase activity
SynMEDNS5_00422	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynMEDNS5_00423	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynMEDNS5_00424	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynMEDNS5_00425	COG0563	adenylate kinase activity
SynMEDNS5_00426	COG0201	protein transport
SynMEDNS5_00427	COG0200	Binds to the 23S rRNA
SynMEDNS5_00428	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynMEDNS5_00429	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynMEDNS5_00430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynMEDNS5_00431	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynMEDNS5_00432	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynMEDNS5_00433	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynMEDNS5_00434	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynMEDNS5_00435	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynMEDNS5_00436	COG0255	Belongs to the universal ribosomal protein uL29 family
SynMEDNS5_00437	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynMEDNS5_00438	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynMEDNS5_00439	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynMEDNS5_00440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynMEDNS5_00441	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynMEDNS5_00442	COG0089	rRNA binding
SynMEDNS5_00443	COG0088	Forms part of the polypeptide exit tunnel
SynMEDNS5_00444	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynMEDNS5_00448	COG3854	ATPases associated with a variety of cellular activities
SynMEDNS5_00451	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynMEDNS5_00455	COG0287	Prephenate dehydrogenase
SynMEDNS5_00457	COG3001	Fructosamine kinase
SynMEDNS5_00461	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynMEDNS5_00462	COG1606	tRNA processing
SynMEDNS5_00463	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynMEDNS5_00464	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynMEDNS5_00467	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynMEDNS5_00468	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynMEDNS5_00469	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynMEDNS5_00471	COG5002	protein histidine kinase activity
SynMEDNS5_00472	COG0772	Belongs to the SEDS family
SynMEDNS5_00473	COG0489	protein tyrosine kinase activity
SynMEDNS5_00474	COG0408	coproporphyrinogen oxidase activity
SynMEDNS5_00486	COG0667	Aldo Keto reductase
SynMEDNS5_00488	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynMEDNS5_00490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynMEDNS5_00491	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynMEDNS5_00491	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynMEDNS5_00492	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynMEDNS5_00524	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMEDNS5_00530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynMEDNS5_00533	COG1070	Carbohydrate kinase
SynMEDNS5_00534	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynMEDNS5_00535	COG0546	phosphoglycolate phosphatase activity
SynMEDNS5_00536	COG0539	negative regulation of cytoplasmic translation
SynMEDNS5_00537	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynMEDNS5_00542	COG0589	response to stress
SynMEDNS5_00545	COG2890	protein-(glutamine-N5) methyltransferase activity
SynMEDNS5_00546	COG0009	L-threonylcarbamoyladenylate synthase
SynMEDNS5_00550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynMEDNS5_00551	COG2894	cell division
SynMEDNS5_00552	COG0850	regulation of cytokinetic process
SynMEDNS5_00553	COG1078	dGTPase activity
SynMEDNS5_00554	COG0793	Belongs to the peptidase S41A family
SynMEDNS5_00555	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynMEDNS5_00556	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynMEDNS5_00557	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SynMEDNS5_00566	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynMEDNS5_00567	COG0235	Class ii aldolase
SynMEDNS5_00568	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynMEDNS5_00571	COG0514	ATP-dependent DNA helicase (RecQ)
SynMEDNS5_00572	COG1388	LysM domain
SynMEDNS5_00572	COG1705	Flagellar rod assembly protein muramidase FlgJ
SynMEDNS5_00573	COG1012	belongs to the aldehyde dehydrogenase family
SynMEDNS5_00575	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynMEDNS5_00576	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynMEDNS5_00582	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynMEDNS5_00588	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynMEDNS5_00592	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynMEDNS5_00595	COG1376	ErfK ybiS ycfS ynhG family protein
SynMEDNS5_00597	COG1160	GTP binding
SynMEDNS5_00598	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynMEDNS5_00600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynMEDNS5_00601	COG1799	cell septum assembly
SynMEDNS5_00602	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynMEDNS5_00603	COG0438	transferase activity, transferring glycosyl groups
SynMEDNS5_00605	COG1381	Involved in DNA repair and RecF pathway recombination
SynMEDNS5_00606	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynMEDNS5_00607	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynMEDNS5_00608	COG0321	lipoyl(octanoyl) transferase activity
SynMEDNS5_00609	COG1022	Amp-dependent synthetase and ligase
SynMEDNS5_00612	COG0531	amino acid
SynMEDNS5_00613	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynMEDNS5_00614	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynMEDNS5_00618	COG3239	Fatty acid desaturase
SynMEDNS5_00620	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynMEDNS5_00623	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynMEDNS5_00627	COG1104	cysteine desulfurase activity
SynMEDNS5_00632	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynMEDNS5_00633	COG0579	oxidoreductase
SynMEDNS5_00636	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynMEDNS5_00639	COG2095	MarC family integral membrane protein
SynMEDNS5_00640	COG0181	hydroxymethylbilane synthase activity
SynMEDNS5_00643	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMEDNS5_00645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynMEDNS5_00647	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynMEDNS5_00650	COG0629	single-stranded DNA binding
SynMEDNS5_00652	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynMEDNS5_00653	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynMEDNS5_00655	COG0442	prolyl-tRNA aminoacylation
SynMEDNS5_00658	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynMEDNS5_00662	COG0681	Belongs to the peptidase S26 family
SynMEDNS5_00668	COG0768	penicillin binding
SynMEDNS5_00669	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynMEDNS5_00671	COG0415	Belongs to the DNA photolyase family
SynMEDNS5_00673	COG0233	cytoplasmic translational termination
SynMEDNS5_00674	COG0528	UMP kinase activity
SynMEDNS5_00677	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynMEDNS5_00679	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMEDNS5_00680	COG0028	Belongs to the TPP enzyme family
SynMEDNS5_00684	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynMEDNS5_00687	COG0539	negative regulation of cytoplasmic translation
SynMEDNS5_00689	COG3396	Phenylacetate-CoA oxygenase
SynMEDNS5_00690	COG5322	oxidoreductase activity
SynMEDNS5_00691	COG0825	malonyl-CoA metabolic process
SynMEDNS5_00693	COG0302	gtp cyclohydrolase
SynMEDNS5_00695	COG0135	phosphoribosylanthranilate isomerase activity
SynMEDNS5_00696	COG1994	Peptidase M50
SynMEDNS5_00696	COG0517	IMP dehydrogenase activity
SynMEDNS5_00697	COG0095	Lipoate-protein ligase
SynMEDNS5_00705	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynMEDNS5_00707	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynMEDNS5_00708	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynMEDNS5_00711	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynMEDNS5_00712	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynMEDNS5_00715	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynMEDNS5_00716	COG1850	ribulose-bisphosphate carboxylase activity
SynMEDNS5_00717	COG4451	ribulose bisphosphate carboxylase, small
SynMEDNS5_00722	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynMEDNS5_00726	COG2091	lysine biosynthetic process via aminoadipic acid
SynMEDNS5_00730	COG0318	PFAM AMP-dependent synthetase and ligase
SynMEDNS5_00737	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynMEDNS5_00738	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMEDNS5_00744	COG0251	oxidation-reduction process
SynMEDNS5_00745	COG3842	ATPase activity
SynMEDNS5_00746	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynMEDNS5_00747	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynMEDNS5_00748	COG1132	(ABC) transporter
SynMEDNS5_00750	COG0456	acetyltransferase
SynMEDNS5_00751	COG1215	transferase activity, transferring glycosyl groups
SynMEDNS5_00753	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMEDNS5_00754	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynMEDNS5_00758	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynMEDNS5_00759	COG0811	peptide transport
SynMEDNS5_00765	COG1845	cytochrome c oxidase, subunit III
SynMEDNS5_00766	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynMEDNS5_00767	COG2010	Cytochrome c
SynMEDNS5_00767	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynMEDNS5_00772	COG0659	secondary active sulfate transmembrane transporter activity
SynMEDNS5_00773	COG0418	dihydroorotase activity
SynMEDNS5_00781	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynMEDNS5_00781	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynMEDNS5_00786	COG0159	tryptophan synthase activity
SynMEDNS5_00789	COG2010	Cytochrome c
SynMEDNS5_00795	COG3339	Conserved Protein
SynMEDNS5_00796	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMEDNS5_00800	COG1376	ErfK ybiS ycfS ynhG family protein
SynMEDNS5_00801	COG0140	phosphoribosyl-ATP diphosphatase activity
SynMEDNS5_00801	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynMEDNS5_00803	COG0542	response to heat
SynMEDNS5_00807	COG3794	PFAM blue (type 1) copper domain protein
SynMEDNS5_00809	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynMEDNS5_00810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynMEDNS5_00819	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynMEDNS5_00826	COG0339	signal peptide processing
SynMEDNS5_00827	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMEDNS5_00828	COG0083	homoserine kinase activity
SynMEDNS5_00829	COG0837	glucose binding
SynMEDNS5_00831	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynMEDNS5_00835	COG0180	Tryptophanyl-tRNA synthetase
SynMEDNS5_00841	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynMEDNS5_00846	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SynMEDNS5_00852	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMEDNS5_00853	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynMEDNS5_00860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynMEDNS5_00861	COG2226	methyltransferase
SynMEDNS5_00868	COG3781	membrane
SynMEDNS5_00872	COG1064	alcohol dehydrogenase
SynMEDNS5_00879	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynMEDNS5_00916	COG0484	heat shock protein binding
SynMEDNS5_00924	COG0405	Gamma-glutamyltransferase
SynMEDNS5_00927	COG3961	Belongs to the TPP enzyme family
SynMEDNS5_00929	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SynMEDNS5_00930	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SynMEDNS5_00931	COG0668	transmembrane transport
SynMEDNS5_00941	COG0671	phosphoesterase, PA-phosphatase related
SynMEDNS5_00946	COG1487	ribonuclease activity
SynMEDNS5_00958	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SynMEDNS5_00976	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMEDNS5_00989	COG0717	Belongs to the dCTP deaminase family
SynMEDNS5_00990	COG0300	oxidoreductase activity
SynMEDNS5_01014	COG0651	ATP synthesis coupled electron transport
SynMEDNS5_01015	COG1006	Multisubunit Na H antiporter MnhC subunit
SynMEDNS5_01024	COG1121	(ABC) transporter
SynMEDNS5_01025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynMEDNS5_01029	COG2010	Cytochrome c
SynMEDNS5_01030	COG0701	Predicted permease
SynMEDNS5_01033	COG1121	(ABC) transporter
SynMEDNS5_01034	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynMEDNS5_01050	COG2124	cytochrome p450
SynMEDNS5_01072	COG0681	Belongs to the peptidase S26 family
SynMEDNS5_01073	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynMEDNS5_01074	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynMEDNS5_01075	COG1376	ErfK ybiS ycfS ynhG family protein
SynMEDNS5_01076	COG0297	glycogen (starch) synthase activity
SynMEDNS5_01078	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynMEDNS5_01080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynMEDNS5_01082	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynMEDNS5_01083	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynMEDNS5_01084	COG2045	Belongs to the ComB family
SynMEDNS5_01087	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynMEDNS5_01088	COG0142	geranyltranstransferase activity
SynMEDNS5_01089	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynMEDNS5_01091	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynMEDNS5_01093	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynMEDNS5_01094	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SynMEDNS5_01097	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynMEDNS5_01098	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMEDNS5_01101	COG2146	nitrite reductase [NAD(P)H] activity
SynMEDNS5_01105	COG0189	ligase activity
SynMEDNS5_01109	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynMEDNS5_01111	COG1132	(ABC) transporter
SynMEDNS5_01113	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynMEDNS5_01114	COG0505	Belongs to the CarA family
SynMEDNS5_01116	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynMEDNS5_01117	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynMEDNS5_01119	COG0154	amidase activity
SynMEDNS5_01120	COG0587	DNA-directed DNA polymerase activity
SynMEDNS5_01122	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynMEDNS5_01123	COG0632	four-way junction helicase activity
SynMEDNS5_01126	COG0358	DNA primase activity
SynMEDNS5_01128	COG0798	PFAM Bile acid sodium symporter
SynMEDNS5_01133	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynMEDNS5_01137	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynMEDNS5_01138	COG2308	Evidence 4 Homologs of previously reported genes of
SynMEDNS5_01143	COG0861	Integral membrane protein TerC family
SynMEDNS5_01147	COG0513	Belongs to the DEAD box helicase family
SynMEDNS5_01148	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynMEDNS5_01150	COG0312	modulator of DNA gyrase
SynMEDNS5_01151	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynMEDNS5_01154	COG0163	prenyltransferase activity
SynMEDNS5_01155	COG0557	exoribonuclease II activity
SynMEDNS5_01158	COG2119	membrane
SynMEDNS5_01162	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynMEDNS5_01162	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynMEDNS5_01166	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynMEDNS5_01167	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMEDNS5_01168	COG1615	UPF0182 protein
SynMEDNS5_01169	COG0450	alkyl hydroperoxide reductase
SynMEDNS5_01172	COG0739	heme binding
SynMEDNS5_01173	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynMEDNS5_01180	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynMEDNS5_01183	COG0129	dihydroxy-acid dehydratase activity
SynMEDNS5_01185	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynMEDNS5_01188	COG2211	Major facilitator Superfamily
SynMEDNS5_01191	COG0300	oxidoreductase activity
SynMEDNS5_01193	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynMEDNS5_01194	COG0047	phosphoribosylformylglycinamidine synthase activity
SynMEDNS5_01195	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynMEDNS5_01197	COG0191	fructose-bisphosphate aldolase activity
SynMEDNS5_01198	COG0673	inositol 2-dehydrogenase activity
SynMEDNS5_01200	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynMEDNS5_01201	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynMEDNS5_01203	COG3954	Phosphoribulokinase
SynMEDNS5_01204	COG0473	3-isopropylmalate dehydrogenase activity
SynMEDNS5_01205	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynMEDNS5_01206	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynMEDNS5_01209	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynMEDNS5_01212	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynMEDNS5_01213	COG2197	response regulator
SynMEDNS5_01215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynMEDNS5_01221	COG1376	ErfK ybiS ycfS ynhG family protein
SynMEDNS5_01226	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMEDNS5_01231	COG3659	wide pore channel activity
SynMEDNS5_01232	COG1119	ATPase activity
SynMEDNS5_01234	COG1051	belongs to the nudix hydrolase family
SynMEDNS5_01242	COG1201	RNA secondary structure unwinding
SynMEDNS5_01246	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynMEDNS5_01248	COG1793	dna ligase
SynMEDNS5_01250	COG1793	dna ligase
SynMEDNS5_01250	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SynMEDNS5_01252	COG2132	Multicopper oxidase
SynMEDNS5_01260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynMEDNS5_01262	COG1175	transmembrane transport
SynMEDNS5_01263	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynMEDNS5_01267	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynMEDNS5_01272	COG0740	serine-type endopeptidase activity
SynMEDNS5_01274	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMEDNS5_01275	COG0577	efflux transmembrane transporter activity
SynMEDNS5_01275	COG1136	(ABC) transporter
SynMEDNS5_01276	COG0469	pyruvate kinase activity
SynMEDNS5_01280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynMEDNS5_01281	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynMEDNS5_01286	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynMEDNS5_01287	COG0598	Magnesium transport protein CorA
SynMEDNS5_01289	COG3842	ATPase activity
SynMEDNS5_01292	COG1653	transport
SynMEDNS5_01293	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynMEDNS5_01294	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynMEDNS5_01295	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynMEDNS5_01296	COG0326	Molecular chaperone. Has ATPase activity
SynMEDNS5_01298	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynMEDNS5_01299	COG0483	inositol monophosphate 1-phosphatase activity
SynMEDNS5_01300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynMEDNS5_01302	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynMEDNS5_01303	COG0581	inorganic phosphate transmembrane transporter activity
SynMEDNS5_01304	COG0573	inorganic phosphate transmembrane transporter activity
SynMEDNS5_01305	COG0443	Heat shock 70 kDa protein
SynMEDNS5_01306	COG0484	heat shock protein binding
SynMEDNS5_01308	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynMEDNS5_01309	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynMEDNS5_01310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynMEDNS5_01311	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynMEDNS5_01311	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynMEDNS5_01312	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynMEDNS5_01313	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynMEDNS5_01318	COG0166	Belongs to the GPI family
SynMEDNS5_01319	COG0495	leucyl-tRNA aminoacylation
SynMEDNS5_01321	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynMEDNS5_01322	COG1104	cysteine desulfurase activity
SynMEDNS5_01327	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynMEDNS5_01328	COG0322	excinuclease ABC activity
SynMEDNS5_01330	COG3046	protein related to deoxyribodipyrimidine photolyase
SynMEDNS5_01331	COG1981	membrane
SynMEDNS5_01335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynMEDNS5_01336	COG0646	methionine synthase
SynMEDNS5_01336	COG1410	methionine synthase
SynMEDNS5_01341	COG2385	sporulation resulting in formation of a cellular spore
SynMEDNS5_01343	COG1191	sigma factor activity
SynMEDNS5_01349	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynMEDNS5_01350	COG0072	phenylalanine-tRNA ligase activity
SynMEDNS5_01351	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynMEDNS5_01352	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynMEDNS5_01353	COG0557	exoribonuclease II activity
SynMEDNS5_01356	COG0363	glucosamine-6-phosphate deaminase activity
SynMEDNS5_01357	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynMEDNS5_01358	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMEDNS5_01359	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynMEDNS5_01360	COG1494	fructose-1,6-bisphosphatase
SynMEDNS5_01361	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynMEDNS5_01365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynMEDNS5_01370	COG1217	gtp-binding protein TYPA
SynMEDNS5_01371	COG0826	peptidase U32
SynMEDNS5_01373	COG0644	oxidoreductase
SynMEDNS5_01374	COG0751	glycine-tRNA ligase activity
SynMEDNS5_01376	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynMEDNS5_01377	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynMEDNS5_01378	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynMEDNS5_01380	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynMEDNS5_01381	COG0052	Belongs to the universal ribosomal protein uS2 family
SynMEDNS5_01382	COG1216	Glycosyl transferase, family 2
SynMEDNS5_01388	COG0612	Peptidase, M16
SynMEDNS5_01392	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynMEDNS5_01393	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SynMEDNS5_01397	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynMEDNS5_01399	COG0174	glutamine synthetase
SynMEDNS5_01402	COG2226	methyltransferase
SynMEDNS5_01407	COG0515	serine threonine protein kinase
SynMEDNS5_01408	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynMEDNS5_01410	COG0628	permease
SynMEDNS5_01411	COG0628	permease
SynMEDNS5_01413	COG0426	domain, Protein
SynMEDNS5_01413	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynMEDNS5_01416	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynMEDNS5_01417	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynMEDNS5_01418	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynMEDNS5_01418	COG0022	dehydrogenase e1 component
SynMEDNS5_01420	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynMEDNS5_01421	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynMEDNS5_01427	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynMEDNS5_01430	COG0271	Belongs to the BolA IbaG family
SynMEDNS5_01431	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynMEDNS5_01433	COG0745	RESPONSE REGULATOR receiver
SynMEDNS5_01437	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynMEDNS5_01447	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynMEDNS5_01451	COG0735	belongs to the Fur family
SynMEDNS5_01453	COG1799	cell septum assembly
SynMEDNS5_01461	COG0420	3'-5' exonuclease activity
SynMEDNS5_01465	COG0477	Major facilitator Superfamily
SynMEDNS5_01467	COG2873	o-acetylhomoserine
SynMEDNS5_01468	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynMEDNS5_01475	COG0765	amino acid transport
SynMEDNS5_01477	COG4597	amino acid ABC transporter
SynMEDNS5_01478	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynMEDNS5_01480	COG0659	secondary active sulfate transmembrane transporter activity
SynMEDNS5_01489	COG0799	negative regulation of ribosome biogenesis
SynMEDNS5_01491	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynMEDNS5_01493	COG1115	amino acid carrier protein
SynMEDNS5_01495	COG1132	(ABC) transporter
SynMEDNS5_01496	COG2501	S4 domain
SynMEDNS5_01497	COG0149	triose-phosphate isomerase activity
SynMEDNS5_01498	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynMEDNS5_01500	COG1429	ligase activity, forming nitrogen-metal bonds
SynMEDNS5_01501	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynMEDNS5_01503	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMEDNS5_01504	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynMEDNS5_01506	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynMEDNS5_01514	COG0642	Histidine kinase
SynMEDNS5_01524	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynMEDNS5_01525	COG0640	Transcriptional regulator
SynMEDNS5_01533	COG3639	organic phosphonate transmembrane transporter activity
SynMEDNS5_01534	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynMEDNS5_01534	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynMEDNS5_01535	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynMEDNS5_01536	COG0436	Aminotransferase
SynMEDNS5_01538	COG1573	uracil-dna glycosylase
SynMEDNS5_01539	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynMEDNS5_01540	COG0793	Belongs to the peptidase S41A family
SynMEDNS5_01544	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynMEDNS5_01566	COG1836	PFAM Integral membrane protein DUF92
SynMEDNS5_01571	COG1122	ATPase activity
SynMEDNS5_01572	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynMEDNS5_01576	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynMEDNS5_01577	COG4106	trans-aconitate 2-methyltransferase activity
SynMEDNS5_01579	COG0668	transmembrane transport
SynMEDNS5_01581	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SynMEDNS5_01595	COG2197	response regulator
SynMEDNS5_01601	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynMEDNS5_01602	COG1074	ATP-dependent DNA helicase activity
SynMEDNS5_01603	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynMEDNS5_01605	COG0513	Belongs to the DEAD box helicase family
SynMEDNS5_01609	COG0724	RNA recognition motif
SynMEDNS5_01611	COG1132	(ABC) transporter
SynMEDNS5_01612	COG0475	glutathione-regulated potassium exporter activity
SynMEDNS5_01612	COG0589	response to stress
SynMEDNS5_01620	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynMEDNS5_01621	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynMEDNS5_01624	COG1054	Belongs to the UPF0176 family
SynMEDNS5_01625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynMEDNS5_01626	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynMEDNS5_01627	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynMEDNS5_01628	COG0019	diaminopimelate decarboxylase activity
SynMEDNS5_01631	COG0542	response to heat
SynMEDNS5_01632	COG0371	Dehydrogenase
SynMEDNS5_01633	COG2226	methyltransferase
SynMEDNS5_01633	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SynMEDNS5_01633	COG0596	Alpha beta hydrolase
SynMEDNS5_01635	COG0575	Belongs to the CDS family
SynMEDNS5_01636	COG1982	Orn Lys Arg decarboxylase major
SynMEDNS5_01638	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynMEDNS5_01640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMEDNS5_01641	COG0745	RESPONSE REGULATOR receiver
SynMEDNS5_01642	COG5002	protein histidine kinase activity
SynMEDNS5_01643	COG1187	pseudouridine synthase activity
SynMEDNS5_01646	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
SynMEDNS5_01648	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynMEDNS5_01651	COG0308	aminopeptidase N
SynMEDNS5_01654	COG2205	protein histidine kinase activity
SynMEDNS5_01658	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynMEDNS5_01659	COG3429	Glucose-6-phosphate dehydrogenase subunit
SynMEDNS5_01659	COG3409	Peptidoglycan-binding domain 1 protein
SynMEDNS5_01660	COG1797	cobyrinic acid a,c-diamide synthase activity
SynMEDNS5_01661	COG1254	Belongs to the acylphosphatase family
SynMEDNS5_01662	COG0406	alpha-ribazole phosphatase activity
SynMEDNS5_01666	COG0142	geranyltranstransferase activity
SynMEDNS5_01667	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynMEDNS5_01668	COG1480	7TM receptor with intracellular HD hydrolase
SynMEDNS5_01669	COG0564	pseudouridine synthase activity
SynMEDNS5_01673	COG0011	TIGRFAM Protein of
SynMEDNS5_01677	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynMEDNS5_01682	COG0395	ABC-type sugar transport system, permease component
SynMEDNS5_01683	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynMEDNS5_01684	COG1543	Belongs to the glycosyl hydrolase 57 family
SynMEDNS5_01687	COG0644	oxidoreductase
SynMEDNS5_01688	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynMEDNS5_01691	COG0516	GMP reductase activity
SynMEDNS5_01692	COG3118	belongs to the thioredoxin family
SynMEDNS5_01693	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynMEDNS5_01695	COG2010	Cytochrome c
SynMEDNS5_01699	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynMEDNS5_01700	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynMEDNS5_01701	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynMEDNS5_01704	COG2166	iron-sulfur cluster assembly
SynMEDNS5_01705	COG0460	homoserine dehydrogenase
SynMEDNS5_01708	COG0601	transmembrane transport
SynMEDNS5_01713	COG4095	Psort location CytoplasmicMembrane, score
SynMEDNS5_01715	COG0012	GTP binding
SynMEDNS5_01716	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynMEDNS5_01717	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynMEDNS5_01717	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynMEDNS5_01718	COG0215	cysteine-tRNA ligase activity
SynMEDNS5_01721	COG0733	neurotransmitter:sodium symporter activity
SynMEDNS5_01722	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynMEDNS5_01734	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynMEDNS5_01736	COG1187	pseudouridine synthase activity
SynMEDNS5_01737	COG2226	methyltransferase
SynMEDNS5_01739	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynMEDNS5_01742	COG2267	carboxylic ester hydrolase activity
SynMEDNS5_01743	COG0440	acetolactate synthase activity
SynMEDNS5_01744	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynMEDNS5_01754	COG0424	maF-like protein
SynMEDNS5_01756	COG1492	cobalamin metabolic process
SynMEDNS5_01761	COG0432	Pfam Uncharacterised protein family UPF0047
SynMEDNS5_01762	COG0477	Major facilitator Superfamily
SynMEDNS5_01782	COG2197	response regulator
SynMEDNS5_01826	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynMEDNS5_01832	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynMEDNS5_01833	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMEDNS5_01836	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynMEDNS5_01836	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynMEDNS5_01864	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynMEDNS5_01865	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynMEDNS5_01866	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynMEDNS5_01868	COG0196	riboflavin kinase activity
SynMEDNS5_01870	COG0352	thiamine-phosphate diphosphorylase activity
SynMEDNS5_01875	COG1691	(AIR) carboxylase
SynMEDNS5_01877	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SynMEDNS5_01878	COG0336	Belongs to the RNA methyltransferase TrmD family
SynMEDNS5_01880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynMEDNS5_01883	COG0670	Belongs to the BI1 family
SynMEDNS5_01884	COG1702	phosphate starvation-inducible protein PhoH
SynMEDNS5_01885	COG0228	four-way junction DNA binding
SynMEDNS5_01886	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynMEDNS5_01889	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynMEDNS5_01890	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynMEDNS5_01891	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMEDNS5_01892	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynMEDNS5_01892	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynMEDNS5_01893	COG0482	sulfurtransferase activity
SynMEDNS5_01894	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynMEDNS5_01898	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SynMEDNS5_01899	COG0134	indole-3-glycerol-phosphate synthase activity
SynMEDNS5_01900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynMEDNS5_01901	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynMEDNS5_01904	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynMEDNS5_01905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynMEDNS5_01906	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynMEDNS5_01907	COG0285	dihydrofolate synthase activity
SynMEDNS5_01908	COG1357	PFAM Pentapeptide repeats (8 copies)
SynMEDNS5_01910	COG0402	S-adenosylhomocysteine deaminase activity
SynMEDNS5_01914	COG4948	Mandelate Racemase Muconate Lactonizing
SynMEDNS5_01915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynMEDNS5_01916	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynMEDNS5_01919	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynMEDNS5_01920	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynMEDNS5_01921	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynMEDNS5_01922	COG4956	integral membrane protein (PIN domain superfamily)
SynMEDNS5_01923	COG0740	serine-type endopeptidase activity
SynMEDNS5_01924	COG0740	serine-type endopeptidase activity
SynMEDNS5_01925	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynMEDNS5_01926	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynMEDNS5_01935	COG2217	Heavy metal translocating P-type atpase
SynMEDNS5_01949	COG0752	glycyl-tRNA synthetase alpha subunit
SynMEDNS5_01951	COG2226	methyltransferase
SynMEDNS5_01953	COG0107	imidazoleglycerol-phosphate synthase activity
SynMEDNS5_01955	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynMEDNS5_01956	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynMEDNS5_01957	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynMEDNS5_01957	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynMEDNS5_01958	COG3695	enzyme binding
SynMEDNS5_01961	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynMEDNS5_01965	COG5002	protein histidine kinase activity
SynMEDNS5_01966	COG2205	protein histidine kinase activity
SynMEDNS5_01971	COG0745	RESPONSE REGULATOR receiver
SynMEDNS5_01972	COG5002	protein histidine kinase activity
SynMEDNS5_01979	COG0481	GTPase activity
SynMEDNS5_01980	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynMEDNS5_01982	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynMEDNS5_01983	COG0523	cobalamin synthesis protein
SynMEDNS5_01985	COG1840	ABC-type Fe3 transport system, periplasmic component
SynMEDNS5_01989	COG2271	Major facilitator Superfamily
SynMEDNS5_01991	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynMEDNS5_01996	COG0277	FAD linked oxidase domain protein
SynMEDNS5_01998	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynMEDNS5_02000	COG1666	GTP binding
SynMEDNS5_02003	COG0330	HflC and HflK could
SynMEDNS5_02006	COG0857	belongs to the CobB CobQ family
SynMEDNS5_02008	COG3000	fatty acid hydroxylase
SynMEDNS5_02008	COG0300	oxidoreductase activity
SynMEDNS5_02009	COG0024	Methionine aminopeptidase
SynMEDNS5_02011	COG0335	large ribosomal subunit rRNA binding
SynMEDNS5_02015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynMEDNS5_02016	COG3263	regulation of cellular component size
SynMEDNS5_02019	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynMEDNS5_02021	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMEDNS5_02022	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynMEDNS5_02025	COG0194	GDP metabolic process
SynMEDNS5_02026	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynMEDNS5_02027	COG0805	protein transport
SynMEDNS5_02029	COG0723	plastoquinol--plastocyanin reductase activity
SynMEDNS5_02030	COG3258	Cytochrome c
SynMEDNS5_02031	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynMEDNS5_02032	COG2875	Belongs to the precorrin methyltransferase family
SynMEDNS5_02035	COG0248	Ppx GppA phosphatase
SynMEDNS5_02036	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynMEDNS5_02037	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynMEDNS5_02038	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynMEDNS5_02040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynMEDNS5_02041	COG1028	Short-chain dehydrogenase reductase Sdr
SynMEDNS5_02043	COG0459	protein refolding
SynMEDNS5_02045	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynMEDNS5_02049	COG0109	protoheme IX farnesyltransferase activity
SynMEDNS5_02050	COG1612	heme a metabolic process
SynMEDNS5_02053	COG1845	cytochrome c oxidase, subunit III
SynMEDNS5_02060	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynMEDNS5_02063	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynMEDNS5_02064	COG1007	ATP synthesis coupled electron transport
SynMEDNS5_02065	COG1136	(ABC) transporter
SynMEDNS5_02065	COG0577	efflux transmembrane transporter activity
SynMEDNS5_02066	COG0745	RESPONSE REGULATOR receiver
SynMEDNS5_02067	COG0739	heme binding
SynMEDNS5_02068	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynMEDNS5_02068	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynMEDNS5_02069	COG0436	Aminotransferase
SynMEDNS5_02070	COG3118	belongs to the thioredoxin family
SynMEDNS5_02071	COG1842	Phage shock protein A
SynMEDNS5_02074	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynMEDNS5_02075	COG0438	transferase activity, transferring glycosyl groups
SynMEDNS5_02076	COG0697	spore germination
SynMEDNS5_02077	COG0616	signal peptide processing
SynMEDNS5_02080	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynMEDNS5_02081	COG0594	ribonuclease P activity
SynMEDNS5_02083	COG0706	membrane insertase activity
SynMEDNS5_02085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMEDNS5_02087	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynMEDNS5_02088	COG0750	zinc metalloprotease
SynMEDNS5_02089	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynMEDNS5_02091	COG1185	polyribonucleotide nucleotidyltransferase activity
SynMEDNS5_02093	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynMEDNS5_02118	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynMEDNS5_02119	COG0776	regulation of translation
SynMEDNS5_02121	COG1523	belongs to the glycosyl hydrolase 13 family
SynMEDNS5_02123	COG2211	Major facilitator Superfamily
SynMEDNS5_02124	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynMEDNS5_02127	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynMEDNS5_02133	COG0284	orotidine-5'-phosphate decarboxylase activity
SynMEDNS5_02137	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynMEDNS5_02142	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynMEDNS5_02145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynMEDNS5_02147	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynMEDNS5_02148	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynMEDNS5_02149	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynMEDNS5_02151	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynMEDNS5_02153	COG0151	Belongs to the GarS family
SynMEDNS5_02154	COG5002	protein histidine kinase activity
SynMEDNS5_02155	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynMEDNS5_02156	COG4251	negative regulation of phosphorylation
SynMEDNS5_02158	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynMEDNS5_02159	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynMEDNS5_02162	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynMEDNS5_02163	COG0217	transcriptional regulatory protein
SynMEDNS5_02167	COG2274	protein secretion by the type I secretion system
SynMEDNS5_02187	COG0363	glucosamine-6-phosphate deaminase activity
SynMEDNS5_02188	COG2385	sporulation resulting in formation of a cellular spore
SynMEDNS5_02188	COG2247	cell wall binding repeat
SynMEDNS5_02189	COG1234	tRNA 3'-trailer cleavage
SynMEDNS5_02190	COG2010	Cytochrome c
SynMEDNS5_02194	COG2264	protein methyltransferase activity
SynMEDNS5_02195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynMEDNS5_02199	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynMEDNS5_02210	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynMEDNS5_02211	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynMEDNS5_02213	COG1970	mechanosensitive ion channel activity
SynMEDNS5_02215	COG0459	protein refolding
SynMEDNS5_02216	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynMEDNS5_02218	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynMEDNS5_02219	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynMEDNS5_02222	COG0387	Pfam Sodium calcium exchanger
SynMEDNS5_02223	COG0006	proline dipeptidase activity
SynMEDNS5_02224	COG1253	flavin adenine dinucleotide binding
SynMEDNS5_02225	COG1160	GTP binding
SynMEDNS5_02226	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynMEDNS5_02227	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynMEDNS5_02227	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynMEDNS5_02229	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynMEDNS5_02231	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynMEDNS5_02233	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynMEDNS5_02234	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynMEDNS5_02235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynMEDNS5_02236	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynMEDNS5_02237	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynMEDNS5_02238	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynMEDNS5_02239	COG0356	it plays a direct role in the translocation of protons across the membrane
SynMEDNS5_02241	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynMEDNS5_02242	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMEDNS5_02246	COG0772	Belongs to the SEDS family
SynMEDNS5_02248	COG1333	cytochrome c biogenesis protein
SynMEDNS5_02249	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynMEDNS5_02253	COG0347	Belongs to the P(II) protein family
SynMEDNS5_02254	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SynMEDNS5_02256	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynMEDNS5_02257	COG0114	fumarate hydratase activity
SynMEDNS5_02258	COG4581	dead DEAH box helicase
SynMEDNS5_02259	COG0385	Bile acid
SynMEDNS5_02260	COG0156	8-amino-7-oxononanoate synthase activity
SynMEDNS5_02263	COG4106	trans-aconitate 2-methyltransferase activity
SynMEDNS5_02263	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynMEDNS5_02266	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynMEDNS5_02269	COG0357	Ribosomal RNA small subunit methyltransferase G
SynMEDNS5_02276	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SynMEDNS5_02277	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynMEDNS5_02278	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMEDNS5_02279	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynMEDNS5_02281	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynMEDNS5_02282	COG0085	RNA polymerase activity
SynMEDNS5_02284	COG0084	hydrolase, TatD family'
SynMEDNS5_02285	COG0268	Binds directly to 16S ribosomal RNA
SynMEDNS5_02286	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynMEDNS5_02287	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynMEDNS5_02288	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMEDNS5_02291	COG2197	response regulator
SynMEDNS5_02297	COG0641	radical SAM
SynMEDNS5_02299	COG0779	Required for maturation of 30S ribosomal subunits
SynMEDNS5_02300	COG0195	Participates in both transcription termination and antitermination
SynMEDNS5_02302	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynMEDNS5_02312	COG2988	succinylglutamate desuccinylase activity
SynMEDNS5_02315	COG0488	(ABC) transporter
SynMEDNS5_02318	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynMEDNS5_02320	COG3842	ATPase activity
SynMEDNS5_02321	COG1193	negative regulation of DNA recombination
SynMEDNS5_02324	COG0113	porphobilinogen synthase activity
SynMEDNS5_02325	COG0484	heat shock protein binding
SynMEDNS5_02327	COG0659	secondary active sulfate transmembrane transporter activity
SynMEDNS5_02328	COG0431	NADPH-dependent FMN reductase
SynMEDNS5_02342	COG0116	Belongs to the methyltransferase superfamily
SynMEDNS5_02346	COG1196	nuclear chromosome segregation
SynMEDNS5_02348	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynMEDNS5_02351	COG0439	Biotin carboxylase
SynMEDNS5_02355	COG0515	serine threonine protein kinase
SynMEDNS5_02359	COG4178	(ABC) transporter
SynMEDNS5_02360	COG0537	adenosine 5'-monophosphoramidase activity
SynMEDNS5_02363	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynMEDNS5_02366	COG0242	peptide deformylase activity
SynMEDNS5_02368	COG0235	Class ii aldolase
SynMEDNS5_02369	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynMEDNS5_02372	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynMEDNS5_02373	COG0719	Fe-S assembly protein
SynMEDNS5_02374	COG0396	ATPase activity
SynMEDNS5_02375	COG0719	Fe-S assembly protein
SynMEDNS5_02376	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynMEDNS5_02378	COG1830	Aldolase
SynMEDNS5_02382	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMEDNS5_02386	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SynMEDNS5_02390	COG0033	Phosphoglucomutase
SynMEDNS5_02394	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SynMEDNS5_02398	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynMEDNS5_02399	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynMEDNS5_02400	COG0175	sulfate reduction
SynMEDNS5_02401	COG1252	NADH dehydrogenase
SynMEDNS5_02402	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynMEDNS5_02403	COG0471	metal ion transport
SynMEDNS5_02403	COG3273	potassium ion transport
SynMEDNS5_02404	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynMEDNS5_02405	COG0569	domain protein
SynMEDNS5_02406	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynMEDNS5_02411	COG0488	(ABC) transporter
SynMEDNS5_02413	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMEDNS5_02416	COG1643	Atp-dependent helicase
SynMEDNS5_02418	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMEDNS5_02420	COG1570	exodeoxyribonuclease VII activity
SynMEDNS5_02421	COG1722	exodeoxyribonuclease VII activity
SynMEDNS5_02432	COG0483	inositol monophosphate 1-phosphatase activity
SynMEDNS5_02435	COG1968	undecaprenyl-diphosphatase activity
SynMEDNS5_02437	COG1555	photosystem II stabilization
SynMEDNS5_02438	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynMEDNS5_02440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynMEDNS5_02443	COG1032	radical SAM domain protein
SynMEDNS5_02449	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynMEDNS5_02454	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynMEDNS5_02456	COG0463	Glycosyl transferase, family 2
SynMEDNS5_02456	COG0457	Tetratricopeptide repeat
SynMEDNS5_02457	COG1587	Uroporphyrinogen-III synthase
SynMEDNS5_02460	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynMEDNS5_02461	COG0316	Belongs to the HesB IscA family
SynMEDNS5_02464	COG1090	epimerase
SynMEDNS5_02468	COG0484	heat shock protein binding
SynMEDNS5_02469	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynMEDNS5_02470	COG3659	wide pore channel activity
SynMEDNS5_02471	COG3659	wide pore channel activity
SynMEDNS5_02473	COG3659	wide pore channel activity
SynMEDNS5_02480	COG1122	ATPase activity
SynMEDNS5_02483	COG0745	RESPONSE REGULATOR receiver
SynMEDNS5_02485	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynMEDNS5_02486	COG2217	Heavy metal translocating P-type atpase
SynMEDNS5_02487	COG3063	Type IV pilus biogenesis stability protein PilW
SynMEDNS5_02488	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynMEDNS5_02490	COG0416	fatty acid biosynthetic process
SynMEDNS5_02491	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynMEDNS5_02492	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynMEDNS5_02495	COG1214	PFAM Peptidase M22, glycoprotease
SynMEDNS5_02497	COG0617	tRNA 3'-terminal CCA addition
SynMEDNS5_02511	COG1562	ergosterol biosynthetic process
SynMEDNS5_02512	COG0745	RESPONSE REGULATOR receiver
SynMEDNS5_02515	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynMEDNS5_02515	COG0493	'glutamate synthase
SynMEDNS5_02518	COG0583	DNA-binding transcription factor activity
SynMEDNS5_02520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynMEDNS5_02521	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMEDNS5_02523	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynMEDNS5_02525	COG2197	response regulator
SynMEDNS5_02528	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynMEDNS5_02529	COG0713	ATP synthesis coupled electron transport
SynMEDNS5_02530	COG0839	Belongs to the complex I subunit 6 family
SynMEDNS5_02531	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMEDNS5_02532	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynMEDNS5_02533	COG0372	Belongs to the citrate synthase family
SynMEDNS5_02537	COG1420	regulation of RNA biosynthetic process
SynMEDNS5_02538	COG0683	leucine binding
SynMEDNS5_02540	COG0133	tryptophan synthase activity
SynMEDNS5_02542	COG0023	Translation Initiation Factor
SynMEDNS5_02543	COG0529	Catalyzes the synthesis of activated sulfate
SynMEDNS5_02544	COG0628	permease
SynMEDNS5_02545	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynMEDNS5_02547	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynMEDNS5_02549	COG0564	pseudouridine synthase activity
SynMEDNS5_02550	COG0745	RESPONSE REGULATOR receiver
SynMEDNS5_02552	COG1104	cysteine desulfurase activity
SynMEDNS5_02554	COG0275	rRNA processing
SynMEDNS5_02555	COG0649	NAD binding
SynMEDNS5_02556	COG0824	Thioesterase
SynMEDNS5_02559	COG1575	Belongs to the MenA family. Type 1 subfamily
SynMEDNS5_02562	COG0189	ligase activity
SynMEDNS5_02563	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynMEDNS5_02566	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynMEDNS5_02568	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynMEDNS5_02569	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynMEDNS5_02570	COG0512	Glutamine amidotransferase of anthranilate synthase
SynMEDNS5_02575	COG0252	asparaginase activity
SynMEDNS5_02576	COG0018	arginyl-trna synthetase
SynMEDNS5_02577	COG0157	Belongs to the NadC ModD family
SynMEDNS5_02580	COG0242	peptide deformylase activity
SynMEDNS5_02581	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynMEDNS5_02583	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynMEDNS5_02585	COG2197	response regulator
SynMEDNS5_02588	COG0564	pseudouridine synthase activity
SynMEDNS5_02590	COG0589	response to stress
SynMEDNS5_02591	COG0126	phosphoglycerate kinase activity
SynMEDNS5_02593	COG2084	Dehydrogenase
SynMEDNS5_02595	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynMEDNS5_02596	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynMEDNS5_02598	COG1450	Type ii and iii secretion system protein
SynMEDNS5_02602	COG0167	dihydroorotate dehydrogenase activity
SynMEDNS5_02607	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynMEDNS5_02608	COG0081	regulation of translation
SynMEDNS5_02609	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynMEDNS5_02610	COG0250	Participates in transcription elongation, termination and antitermination
SynMEDNS5_02611	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynMEDNS5_02612	COG0542	response to heat
SynMEDNS5_02613	COG0346	lactoylglutathione lyase activity
SynMEDNS5_02614	COG0148	phosphopyruvate hydratase activity
SynMEDNS5_02617	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynMEDNS5_02621	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynMEDNS5_02622	COG0237	dephospho-CoA kinase activity
SynMEDNS5_02623	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynMEDNS5_02624	COG2022	thiamine diphosphate biosynthetic process
SynMEDNS5_02624	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynMEDNS5_02626	COG0105	UTP biosynthetic process
SynMEDNS5_02627	COG1166	arginine decarboxylase activity
SynMEDNS5_02630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynMEDNS5_02632	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynMEDNS5_02637	COG0426	domain, Protein
SynMEDNS5_02637	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynMEDNS5_02638	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynMEDNS5_02638	COG0426	domain, Protein
SynMEDNS5_02640	COG1741	Belongs to the pirin family
SynMEDNS5_02646	COG0509	glycine decarboxylation via glycine cleavage system
SynMEDNS5_02647	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynMEDNS5_02651	COG0359	binds to the 23S rRNA
SynMEDNS5_02652	COG1372	Participates in initiation and elongation during chromosome replication
SynMEDNS5_02652	COG0305	Participates in initiation and elongation during chromosome replication
SynMEDNS5_02652	COG1372	Participates in initiation and elongation during chromosome replication
SynMEDNS5_02652	COG0305	Participates in initiation and elongation during chromosome replication
SynMEDNS5_02653	COG0445	tRNA wobble uridine modification
SynMEDNS5_02662	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynMEDNS5_02664	COG0398	Pfam SNARE associated Golgi protein
SynMEDNS5_02667	COG0668	transmembrane transport
SynMEDNS5_02673	COG0525	valine-tRNA ligase activity
SynMEDNS5_02677	COG1028	Short-chain dehydrogenase reductase Sdr
SynMEDNS5_02698	COG3956	TIGRFAM MazG family protein
SynMEDNS5_02700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynMEDNS5_02703	COG0010	Belongs to the arginase family
SynMEDNS5_02707	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynMEDNS5_02708	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynMEDNS5_02709	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMEDNS5_02710	COG0783	Belongs to the Dps family
SynMEDNS5_02715	COG0783	Belongs to the Dps family
SynMEDNS5_02716	COG0504	CTP synthase activity
SynMEDNS5_02717	COG0602	queuosine metabolic process
SynMEDNS5_02718	COG4942	peptidase
SynMEDNS5_02719	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SynMEDNS5_02722	COG4574	serine-type endopeptidase inhibitor activity
SynMEDNS5_02723	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynMEDNS5_02726	COG0531	amino acid
SynMEDNS5_02728	COG0366	Alpha amylase catalytic
SynMEDNS5_02729	COG0463	Glycosyl transferase, family 2
SynMEDNS5_02734	COG0367	asparagine synthase
SynMEDNS5_02735	COG0540	Belongs to the ATCase OTCase family
SynMEDNS5_02739	COG2308	Evidence 4 Homologs of previously reported genes of
SynMEDNS5_02743	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynMEDNS5_02744	COG0746	molybdenum cofactor guanylyltransferase activity
SynMEDNS5_02746	COG2223	nitrite transmembrane transporter activity
SynMEDNS5_02747	COG0243	molybdopterin cofactor binding
SynMEDNS5_02752	COG0315	cyclic pyranopterin monophosphate synthase activity
SynMEDNS5_02753	COG0303	'Molybdopterin
SynMEDNS5_02754	COG0314	molybdopterin synthase activity
SynMEDNS5_02755	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SynMEDNS5_02756	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynMEDNS5_02757	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynMEDNS5_02760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynMEDNS5_02762	COG2116	formate transmembrane transporter activity
SynMEDNS5_02764	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynMEDNS5_02766	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynMEDNS5_02769	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynMEDNS5_02770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMEDNS5_02771	COG0170	dolichyl monophosphate biosynthetic process
SynMEDNS5_02773	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynMEDNS5_02774	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynMEDNS5_02777	COG0788	formyltetrahydrofolate deformylase activity
SynMEDNS5_02779	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynMEDNS5_02781	COG0443	Heat shock 70 kDa protein
SynMEDNS5_02782	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynMEDNS5_02784	COG0360	Binds together with S18 to 16S ribosomal RNA
SynMEDNS5_02786	COG0137	argininosuccinate synthase activity
SynMEDNS5_02789	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynMEDNS5_02795	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynMEDNS5_02796	COG0438	transferase activity, transferring glycosyl groups
SynMEDNS5_02799	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynMEDNS5_02800	COG0497	DNA recombination
SynMEDNS5_02801	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynMEDNS5_02803	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine