locus-tag	class	description
SynMITS9220_00001	COG0592	DNA-directed DNA polymerase activity
SynMITS9220_00003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynMITS9220_00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynMITS9220_00007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynMITS9220_00010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynMITS9220_00011	COG0552	protein localization to endoplasmic reticulum
SynMITS9220_00012	COG2208	phosphoserine phosphatase activity
SynMITS9220_00013	COG0165	Argininosuccinate lyase
SynMITS9220_00014	COG0724	RNA recognition motif
SynMITS9220_00015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynMITS9220_00017	COG2081	HI0933 family
SynMITS9220_00018	COG1459	type II secretion system
SynMITS9220_00020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynMITS9220_00021	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynMITS9220_00022	COG0484	heat shock protein binding
SynMITS9220_00024	COG1162	GTPase activity
SynMITS9220_00025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynMITS9220_00026	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynMITS9220_00027	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynMITS9220_00028	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynMITS9220_00029	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynMITS9220_00030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynMITS9220_00031	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynMITS9220_00032	COG0511	ligase activity, forming carbon-carbon bonds
SynMITS9220_00033	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynMITS9220_00051	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynMITS9220_00052	COG0519	Catalyzes the synthesis of GMP from XMP
SynMITS9220_00052	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynMITS9220_00055	COG0768	penicillin binding
SynMITS9220_00056	COG0438	transferase activity, transferring glycosyl groups
SynMITS9220_00057	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynMITS9220_00059	COG2022	thiamine diphosphate biosynthetic process
SynMITS9220_00062	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynMITS9220_00063	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynMITS9220_00066	COG2385	sporulation resulting in formation of a cellular spore
SynMITS9220_00067	COG1215	transferase activity, transferring glycosyl groups
SynMITS9220_00068	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynMITS9220_00070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynMITS9220_00071	COG0740	serine-type endopeptidase activity
SynMITS9220_00072	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynMITS9220_00073	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynMITS9220_00074	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynMITS9220_00075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynMITS9220_00077	COG0037	tRNA processing
SynMITS9220_00080	COG0556	nucleotide-excision repair
SynMITS9220_00081	COG0527	aspartate kinase activity
SynMITS9220_00083	COG2082	Precorrin-8x methylmutase
SynMITS9220_00084	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynMITS9220_00086	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynMITS9220_00089	COG0438	transferase activity, transferring glycosyl groups
SynMITS9220_00090	COG0653	protein targeting
SynMITS9220_00091	COG1045	serine acetyltransferase
SynMITS9220_00092	COG1725	Transcriptional regulator
SynMITS9220_00094	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynMITS9220_00095	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynMITS9220_00096	COG0187	DNA topoisomerase II activity
SynMITS9220_00096	COG1372	Participates in initiation and elongation during chromosome replication
SynMITS9220_00098	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynMITS9220_00099	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynMITS9220_00100	COG0386	Belongs to the glutathione peroxidase family
SynMITS9220_00101	COG2239	Acts as a magnesium transporter
SynMITS9220_00102	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMITS9220_00103	COG0596	Alpha beta hydrolase
SynMITS9220_00110	COG0802	atpase or kinase
SynMITS9220_00111	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynMITS9220_00112	COG0586	Pfam SNARE associated Golgi protein
SynMITS9220_00113	COG0629	single-stranded DNA binding
SynMITS9220_00118	COG0745	RESPONSE REGULATOR receiver
SynMITS9220_00119	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynMITS9220_00122	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynMITS9220_00123	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynMITS9220_00124	COG0515	serine threonine protein kinase
SynMITS9220_00124	COG1357	PFAM Pentapeptide repeats (8 copies)
SynMITS9220_00125	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynMITS9220_00126	COG2255	four-way junction helicase activity
SynMITS9220_00128	COG1473	amidohydrolase
SynMITS9220_00132	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynMITS9220_00135	COG0463	Glycosyl transferase, family 2
SynMITS9220_00137	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynMITS9220_00139	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynMITS9220_00140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynMITS9220_00141	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynMITS9220_00142	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMITS9220_00143	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynMITS9220_00144	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynMITS9220_00144	COG0662	Cupin 2, conserved barrel domain protein
SynMITS9220_00145	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynMITS9220_00146	COG1088	dTDP-glucose 4,6-dehydratase activity
SynMITS9220_00152	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMITS9220_00153	COG0571	ribonuclease III activity
SynMITS9220_00158	COG0058	SHG alpha-glucan phosphorylase activity
SynMITS9220_00159	COG0475	glutathione-regulated potassium exporter activity
SynMITS9220_00164	COG1304	FMN binding
SynMITS9220_00165	COG0277	FAD linked oxidase domain protein
SynMITS9220_00166	COG0538	isocitrate dehydrogenase activity
SynMITS9220_00167	COG0463	Glycosyl transferase, family 2
SynMITS9220_00170	COG5398	heme oxygenase
SynMITS9220_00172	COG1132	(ABC) transporter
SynMITS9220_00176	COG0617	tRNA 3'-terminal CCA addition
SynMITS9220_00177	COG2192	nodulation
SynMITS9220_00180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynMITS9220_00182	COG0367	asparagine synthase
SynMITS9220_00186	COG0297	glycogen (starch) synthase activity
SynMITS9220_00198	COG1086	Polysaccharide biosynthesis protein
SynMITS9220_00199	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SynMITS9220_00200	COG2089	acid synthase
SynMITS9220_00202	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynMITS9220_00205	COG2089	acid synthase
SynMITS9220_00208	COG1132	(ABC) transporter
SynMITS9220_00219	COG0367	asparagine synthase
SynMITS9220_00221	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SynMITS9220_00225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynMITS9220_00227	COG0709	Synthesizes selenophosphate from selenide and ATP
SynMITS9220_00228	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynMITS9220_00236	COG0124	histidyl-tRNA synthetase
SynMITS9220_00237	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynMITS9220_00241	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynMITS9220_00242	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynMITS9220_00247	COG4447	cellulose binding
SynMITS9220_00248	COG1773	rubredoxin
SynMITS9220_00249	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMITS9220_00250	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMITS9220_00251	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMITS9220_00252	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynMITS9220_00253	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SynMITS9220_00255	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynMITS9220_00255	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynMITS9220_00258	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SynMITS9220_00261	COG0494	nUDIX hydrolase
SynMITS9220_00262	COG0415	Belongs to the DNA photolyase family
SynMITS9220_00268	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynMITS9220_00269	COG0131	Imidazoleglycerol-phosphate dehydratase
SynMITS9220_00270	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynMITS9220_00272	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynMITS9220_00276	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynMITS9220_00277	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynMITS9220_00280	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynMITS9220_00284	COG1253	flavin adenine dinucleotide binding
SynMITS9220_00285	COG0673	inositol 2-dehydrogenase activity
SynMITS9220_00289	COG0343	queuine tRNA-ribosyltransferase activity
SynMITS9220_00290	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SynMITS9220_00294	COG0138	bifunctional purine biosynthesis protein purh
SynMITS9220_00300	COG0716	FMN binding
SynMITS9220_00307	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynMITS9220_00308	COG0004	ammonium transporteR
SynMITS9220_00310	COG1489	DNA binding
SynMITS9220_00311	COG0728	peptidoglycan biosynthetic process
SynMITS9220_00317	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynMITS9220_00319	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynMITS9220_00320	COG1546	Belongs to the CinA family
SynMITS9220_00320	COG1058	Belongs to the CinA family
SynMITS9220_00321	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynMITS9220_00322	COG0066	3-isopropylmalate dehydratase activity
SynMITS9220_00330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynMITS9220_00331	COG0193	aminoacyl-tRNA hydrolase activity
SynMITS9220_00335	COG4372	Transposase
SynMITS9220_00336	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMITS9220_00337	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynMITS9220_00340	COG0717	Belongs to the dCTP deaminase family
SynMITS9220_00342	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynMITS9220_00346	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynMITS9220_00349	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynMITS9220_00353	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynMITS9220_00357	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynMITS9220_00359	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynMITS9220_00361	COG2094	Belongs to the DNA glycosylase MPG family
SynMITS9220_00362	COG0540	Belongs to the ATCase OTCase family
SynMITS9220_00367	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynMITS9220_00369	COG3536	Protein conserved in bacteria
SynMITS9220_00370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynMITS9220_00374	COG0529	Catalyzes the synthesis of activated sulfate
SynMITS9220_00374	COG2046	Belongs to the sulfate adenylyltransferase family
SynMITS9220_00375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMITS9220_00378	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynMITS9220_00380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynMITS9220_00381	COG2226	methyltransferase
SynMITS9220_00384	COG4176	ABC-type proline glycine betaine transport system permease component
SynMITS9220_00385	COG2113	Glycine betaine
SynMITS9220_00390	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynMITS9220_00391	COG0436	Aminotransferase
SynMITS9220_00393	COG1530	ribonuclease E activity
SynMITS9220_00394	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynMITS9220_00396	COG0077	Prephenate dehydratase
SynMITS9220_00396	COG1605	Chorismate mutase
SynMITS9220_00397	COG2226	methyltransferase
SynMITS9220_00398	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynMITS9220_00399	COG0051	transcription antitermination factor activity, RNA binding
SynMITS9220_00400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynMITS9220_00401	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynMITS9220_00402	COG0049	tRNA binding
SynMITS9220_00403	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynMITS9220_00406	COG0070	glutamate synthase
SynMITS9220_00406	COG0067	glutamate synthase
SynMITS9220_00406	COG0069	glutamate synthase activity
SynMITS9220_00408	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynMITS9220_00412	COG2885	chlorophyll binding
SynMITS9220_00413	COG2885	chlorophyll binding
SynMITS9220_00421	COG0463	Glycosyl transferase, family 2
SynMITS9220_00425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynMITS9220_00427	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynMITS9220_00429	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynMITS9220_00430	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynMITS9220_00431	COG0101	tRNA pseudouridine synthase activity
SynMITS9220_00432	COG0203	ribosomal protein L17
SynMITS9220_00433	COG0202	RNA polymerase activity
SynMITS9220_00434	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynMITS9220_00435	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynMITS9220_00437	COG0563	adenylate kinase activity
SynMITS9220_00438	COG0201	protein transport
SynMITS9220_00439	COG0200	Binds to the 23S rRNA
SynMITS9220_00440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynMITS9220_00441	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynMITS9220_00442	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynMITS9220_00443	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynMITS9220_00444	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynMITS9220_00445	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynMITS9220_00446	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynMITS9220_00447	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynMITS9220_00448	COG0255	Belongs to the universal ribosomal protein uL29 family
SynMITS9220_00449	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynMITS9220_00450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynMITS9220_00451	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynMITS9220_00452	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynMITS9220_00453	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynMITS9220_00454	COG0089	rRNA binding
SynMITS9220_00455	COG0088	Forms part of the polypeptide exit tunnel
SynMITS9220_00456	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynMITS9220_00460	COG3854	ATPases associated with a variety of cellular activities
SynMITS9220_00463	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynMITS9220_00470	COG3001	Fructosamine kinase
SynMITS9220_00474	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynMITS9220_00475	COG1606	tRNA processing
SynMITS9220_00476	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynMITS9220_00477	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynMITS9220_00480	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynMITS9220_00481	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynMITS9220_00482	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynMITS9220_00485	COG0772	Belongs to the SEDS family
SynMITS9220_00486	COG0489	protein tyrosine kinase activity
SynMITS9220_00487	COG0408	coproporphyrinogen oxidase activity
SynMITS9220_00498	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynMITS9220_00500	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynMITS9220_00501	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynMITS9220_00501	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynMITS9220_00502	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynMITS9220_00530	COG0237	dephospho-CoA kinase activity
SynMITS9220_00535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMITS9220_00544	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynMITS9220_00547	COG1070	Carbohydrate kinase
SynMITS9220_00548	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynMITS9220_00550	COG0539	negative regulation of cytoplasmic translation
SynMITS9220_00551	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynMITS9220_00556	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynMITS9220_00556	COG0758	DNA mediated transformation
SynMITS9220_00557	COG2890	protein-(glutamine-N5) methyltransferase activity
SynMITS9220_00558	COG0009	L-threonylcarbamoyladenylate synthase
SynMITS9220_00562	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynMITS9220_00563	COG2894	cell division
SynMITS9220_00564	COG0850	regulation of cytokinetic process
SynMITS9220_00565	COG1078	dGTPase activity
SynMITS9220_00566	COG0793	Belongs to the peptidase S41A family
SynMITS9220_00567	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynMITS9220_00568	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynMITS9220_00576	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynMITS9220_00577	COG0235	Class ii aldolase
SynMITS9220_00578	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynMITS9220_00581	COG0514	ATP-dependent DNA helicase (RecQ)
SynMITS9220_00582	COG0791	NLP P60 protein
SynMITS9220_00582	COG1388	LysM domain
SynMITS9220_00583	COG1012	belongs to the aldehyde dehydrogenase family
SynMITS9220_00585	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynMITS9220_00586	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynMITS9220_00589	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynMITS9220_00593	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynMITS9220_00597	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynMITS9220_00601	COG1376	ErfK ybiS ycfS ynhG family protein
SynMITS9220_00602	COG1160	GTP binding
SynMITS9220_00603	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynMITS9220_00605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynMITS9220_00606	COG1799	cell septum assembly
SynMITS9220_00607	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynMITS9220_00608	COG0438	transferase activity, transferring glycosyl groups
SynMITS9220_00610	COG1381	Involved in DNA repair and RecF pathway recombination
SynMITS9220_00611	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynMITS9220_00612	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynMITS9220_00613	COG0321	lipoyl(octanoyl) transferase activity
SynMITS9220_00614	COG1022	Amp-dependent synthetase and ligase
SynMITS9220_00634	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynMITS9220_00635	COG0531	amino acid
SynMITS9220_00636	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynMITS9220_00637	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynMITS9220_00649	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynMITS9220_00650	COG1104	cysteine desulfurase activity
SynMITS9220_00653	COG1132	(ABC) transporter
SynMITS9220_00661	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynMITS9220_00662	COG0579	oxidoreductase
SynMITS9220_00666	COG0481	GTPase activity
SynMITS9220_00668	COG4969	Belongs to the N-Me-Phe pilin family
SynMITS9220_00676	COG2274	protein secretion by the type I secretion system
SynMITS9220_00678	COG0481	GTPase activity
SynMITS9220_00681	COG2205	protein histidine kinase activity
SynMITS9220_00682	COG0745	RESPONSE REGULATOR receiver
SynMITS9220_00685	COG5002	protein histidine kinase activity
SynMITS9220_00686	COG4176	ABC-type proline glycine betaine transport system permease component
SynMITS9220_00688	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynMITS9220_00689	COG0316	Belongs to the HesB IscA family
SynMITS9220_00693	COG3695	enzyme binding
SynMITS9220_00695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynMITS9220_00695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynMITS9220_00696	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynMITS9220_00697	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynMITS9220_00699	COG0107	imidazoleglycerol-phosphate synthase activity
SynMITS9220_00701	COG2226	methyltransferase
SynMITS9220_00703	COG0752	glycyl-tRNA synthetase alpha subunit
SynMITS9220_00712	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynMITS9220_00713	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynMITS9220_00714	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynMITS9220_00715	COG0740	serine-type endopeptidase activity
SynMITS9220_00716	COG0740	serine-type endopeptidase activity
SynMITS9220_00717	COG4956	integral membrane protein (PIN domain superfamily)
SynMITS9220_00718	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynMITS9220_00719	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynMITS9220_00720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynMITS9220_00723	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynMITS9220_00724	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynMITS9220_00725	COG4948	Mandelate Racemase Muconate Lactonizing
SynMITS9220_00737	COG0285	dihydrofolate synthase activity
SynMITS9220_00738	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynMITS9220_00740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynMITS9220_00741	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynMITS9220_00747	COG0438	transferase activity, transferring glycosyl groups
SynMITS9220_00753	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynMITS9220_00754	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynMITS9220_00755	COG0134	indole-3-glycerol-phosphate synthase activity
SynMITS9220_00760	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynMITS9220_00761	COG0482	sulfurtransferase activity
SynMITS9220_00762	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynMITS9220_00762	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynMITS9220_00764	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMITS9220_00765	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynMITS9220_00766	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynMITS9220_00768	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynMITS9220_00770	COG1702	phosphate starvation-inducible protein PhoH
SynMITS9220_00773	COG0477	Major facilitator Superfamily
SynMITS9220_00775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynMITS9220_00777	COG0336	Belongs to the RNA methyltransferase TrmD family
SynMITS9220_00778	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SynMITS9220_00780	COG1691	(AIR) carboxylase
SynMITS9220_00784	COG0352	thiamine-phosphate diphosphorylase activity
SynMITS9220_00786	COG0196	riboflavin kinase activity
SynMITS9220_00788	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynMITS9220_00789	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynMITS9220_00790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynMITS9220_00813	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynMITS9220_00816	COG3119	arylsulfatase activity
SynMITS9220_00835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynMITS9220_00835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynMITS9220_00837	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMITS9220_00838	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynMITS9220_00848	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynMITS9220_00853	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynMITS9220_00861	COG1525	nuclease
SynMITS9220_00871	COG0515	serine threonine protein kinase
SynMITS9220_00891	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynMITS9220_00926	COG0477	Major facilitator Superfamily
SynMITS9220_00927	COG0432	Pfam Uncharacterised protein family UPF0047
SynMITS9220_00933	COG1492	cobalamin metabolic process
SynMITS9220_00935	COG0424	maF-like protein
SynMITS9220_00940	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynMITS9220_00941	COG0440	acetolactate synthase activity
SynMITS9220_00942	COG1073	alpha beta
SynMITS9220_00945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynMITS9220_00947	COG2226	methyltransferase
SynMITS9220_00948	COG1187	pseudouridine synthase activity
SynMITS9220_00950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynMITS9220_00951	COG0492	ferredoxin-NADP+ reductase activity
SynMITS9220_00959	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SynMITS9220_00962	COG3411	Ferredoxin
SynMITS9220_00963	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynMITS9220_00964	COG0733	neurotransmitter:sodium symporter activity
SynMITS9220_00967	COG0215	cysteine-tRNA ligase activity
SynMITS9220_00970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynMITS9220_00970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynMITS9220_00971	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynMITS9220_00972	COG0012	GTP binding
SynMITS9220_00974	COG0678	peroxiredoxin activity
SynMITS9220_00980	COG0601	transmembrane transport
SynMITS9220_00981	COG0747	negative chemotaxis
SynMITS9220_00983	COG0460	homoserine dehydrogenase
SynMITS9220_00984	COG2166	iron-sulfur cluster assembly
SynMITS9220_00986	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynMITS9220_01002	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynMITS9220_01003	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynMITS9220_01007	COG2010	Cytochrome c
SynMITS9220_01009	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynMITS9220_01010	COG3118	belongs to the thioredoxin family
SynMITS9220_01011	COG0516	GMP reductase activity
SynMITS9220_01013	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynMITS9220_01014	COG0644	oxidoreductase
SynMITS9220_01015	COG1543	Belongs to the glycosyl hydrolase 57 family
SynMITS9220_01016	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynMITS9220_01017	COG0395	ABC-type sugar transport system, permease component
SynMITS9220_01024	COG0011	TIGRFAM Protein of
SynMITS9220_01027	COG0564	pseudouridine synthase activity
SynMITS9220_01028	COG1480	7TM receptor with intracellular HD hydrolase
SynMITS9220_01029	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynMITS9220_01030	COG0142	geranyltranstransferase activity
SynMITS9220_01035	COG1254	Belongs to the acylphosphatase family
SynMITS9220_01036	COG1797	cobyrinic acid a,c-diamide synthase activity
SynMITS9220_01037	COG3409	Peptidoglycan-binding domain 1 protein
SynMITS9220_01037	COG3429	Glucose-6-phosphate dehydrogenase subunit
SynMITS9220_01038	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynMITS9220_01039	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SynMITS9220_01042	COG2205	protein histidine kinase activity
SynMITS9220_01045	COG0308	aminopeptidase N
SynMITS9220_01050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynMITS9220_01053	COG1640	4-alpha-glucanotransferase
SynMITS9220_01055	COG1187	pseudouridine synthase activity
SynMITS9220_01056	COG5002	protein histidine kinase activity
SynMITS9220_01057	COG0745	RESPONSE REGULATOR receiver
SynMITS9220_01058	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMITS9220_01060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynMITS9220_01061	COG1982	Orn Lys Arg decarboxylase major
SynMITS9220_01062	COG0575	Belongs to the CDS family
SynMITS9220_01064	COG0596	Alpha beta hydrolase
SynMITS9220_01065	COG0371	Dehydrogenase
SynMITS9220_01066	COG0542	response to heat
SynMITS9220_01068	COG0456	acetyltransferase
SynMITS9220_01069	COG0019	diaminopimelate decarboxylase activity
SynMITS9220_01070	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynMITS9220_01071	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynMITS9220_01072	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynMITS9220_01073	COG1054	Belongs to the UPF0176 family
SynMITS9220_01076	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynMITS9220_01077	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynMITS9220_01081	COG0589	response to stress
SynMITS9220_01081	COG0475	glutathione-regulated potassium exporter activity
SynMITS9220_01082	COG1132	(ABC) transporter
SynMITS9220_01084	COG0724	RNA recognition motif
SynMITS9220_01086	COG0513	Belongs to the DEAD box helicase family
SynMITS9220_01088	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynMITS9220_01089	COG1074	ATP-dependent DNA helicase activity
SynMITS9220_01090	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynMITS9220_01109	COG3239	Fatty acid desaturase
SynMITS9220_01144	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SynMITS9220_01145	COG0668	transmembrane transport
SynMITS9220_01147	COG4106	trans-aconitate 2-methyltransferase activity
SynMITS9220_01148	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynMITS9220_01154	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynMITS9220_01155	COG1122	ATPase activity
SynMITS9220_01159	COG1836	PFAM Integral membrane protein DUF92
SynMITS9220_01160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMITS9220_01163	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynMITS9220_01168	COG0793	Belongs to the peptidase S41A family
SynMITS9220_01169	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynMITS9220_01170	COG1573	uracil-dna glycosylase
SynMITS9220_01172	COG0436	Aminotransferase
SynMITS9220_01173	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynMITS9220_01174	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynMITS9220_01174	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynMITS9220_01175	COG3639	organic phosphonate transmembrane transporter activity
SynMITS9220_01189	COG1126	abc transporter atp-binding protein
SynMITS9220_01190	COG0765	amino acid transport
SynMITS9220_01192	COG4597	amino acid ABC transporter
SynMITS9220_01193	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynMITS9220_01196	COG0659	secondary active sulfate transmembrane transporter activity
SynMITS9220_01206	COG0799	negative regulation of ribosome biogenesis
SynMITS9220_01208	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynMITS9220_01210	COG1115	amino acid carrier protein
SynMITS9220_01212	COG1132	(ABC) transporter
SynMITS9220_01214	COG0149	triose-phosphate isomerase activity
SynMITS9220_01215	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynMITS9220_01218	COG1429	ligase activity, forming nitrogen-metal bonds
SynMITS9220_01219	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynMITS9220_01221	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMITS9220_01224	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynMITS9220_01238	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SynMITS9220_01243	COG3659	wide pore channel activity
SynMITS9220_01245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynMITS9220_01246	COG1494	fructose-1,6-bisphosphatase
SynMITS9220_01247	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynMITS9220_01248	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMITS9220_01249	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynMITS9220_01250	COG0363	glucosamine-6-phosphate deaminase activity
SynMITS9220_01253	COG0129	dihydroxy-acid dehydratase activity
SynMITS9220_01255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynMITS9220_01256	COG1357	PFAM Pentapeptide repeats (8 copies)
SynMITS9220_01258	COG3895	Periplasmic Protein
SynMITS9220_01261	COG0300	oxidoreductase activity
SynMITS9220_01263	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynMITS9220_01264	COG0047	phosphoribosylformylglycinamidine synthase activity
SynMITS9220_01265	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynMITS9220_01269	COG0191	fructose-bisphosphate aldolase activity
SynMITS9220_01270	COG3588	fructose-bisphosphate aldolase
SynMITS9220_01274	COG0673	inositol 2-dehydrogenase activity
SynMITS9220_01276	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynMITS9220_01277	COG1528	Iron-storage protein
SynMITS9220_01278	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynMITS9220_01280	COG3954	Phosphoribulokinase
SynMITS9220_01281	COG0473	3-isopropylmalate dehydrogenase activity
SynMITS9220_01282	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynMITS9220_01285	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynMITS9220_01288	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynMITS9220_01292	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynMITS9220_01293	COG2197	response regulator
SynMITS9220_01295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynMITS9220_01298	COG0517	IMP dehydrogenase activity
SynMITS9220_01300	COG1376	ErfK ybiS ycfS ynhG family protein
SynMITS9220_01304	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMITS9220_01311	COG1119	ATPase activity
SynMITS9220_01336	COG1201	RNA secondary structure unwinding
SynMITS9220_01337	COG1793	dna ligase
SynMITS9220_01340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SynMITS9220_01347	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynMITS9220_01349	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynMITS9220_01363	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynMITS9220_01367	COG0740	serine-type endopeptidase activity
SynMITS9220_01368	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMITS9220_01369	COG0577	efflux transmembrane transporter activity
SynMITS9220_01369	COG1136	(ABC) transporter
SynMITS9220_01370	COG0469	pyruvate kinase activity
SynMITS9220_01375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynMITS9220_01376	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynMITS9220_01381	COG3842	ATPase activity
SynMITS9220_01384	COG1653	transport
SynMITS9220_01385	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynMITS9220_01386	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynMITS9220_01387	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynMITS9220_01388	COG0326	Molecular chaperone. Has ATPase activity
SynMITS9220_01390	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynMITS9220_01391	COG0483	inositol monophosphate 1-phosphatase activity
SynMITS9220_01394	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynMITS9220_01396	COG0573	inorganic phosphate transmembrane transporter activity
SynMITS9220_01397	COG0443	Heat shock 70 kDa protein
SynMITS9220_01398	COG0484	heat shock protein binding
SynMITS9220_01400	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynMITS9220_01401	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynMITS9220_01402	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynMITS9220_01403	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynMITS9220_01403	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynMITS9220_01404	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynMITS9220_01405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynMITS9220_01411	COG0166	Belongs to the GPI family
SynMITS9220_01412	COG0495	leucyl-tRNA aminoacylation
SynMITS9220_01416	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynMITS9220_01422	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynMITS9220_01423	COG0322	excinuclease ABC activity
SynMITS9220_01425	COG3046	protein related to deoxyribodipyrimidine photolyase
SynMITS9220_01426	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
SynMITS9220_01430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynMITS9220_01431	COG0646	methionine synthase
SynMITS9220_01431	COG1410	methionine synthase
SynMITS9220_01436	COG2385	sporulation resulting in formation of a cellular spore
SynMITS9220_01438	COG1191	sigma factor activity
SynMITS9220_01444	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynMITS9220_01445	COG0072	phenylalanine-tRNA ligase activity
SynMITS9220_01446	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynMITS9220_01447	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynMITS9220_01448	COG0557	exoribonuclease II activity
SynMITS9220_01450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynMITS9220_01457	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynMITS9220_01458	COG0739	heme binding
SynMITS9220_01461	COG0450	alkyl hydroperoxide reductase
SynMITS9220_01462	COG1615	UPF0182 protein
SynMITS9220_01463	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMITS9220_01464	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynMITS9220_01468	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynMITS9220_01468	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynMITS9220_01473	COG2119	membrane
SynMITS9220_01475	COG0557	exoribonuclease II activity
SynMITS9220_01476	COG0163	prenyltransferase activity
SynMITS9220_01479	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynMITS9220_01480	COG0312	modulator of DNA gyrase
SynMITS9220_01482	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynMITS9220_01483	COG0513	Belongs to the DEAD box helicase family
SynMITS9220_01487	COG0861	Integral membrane protein TerC family
SynMITS9220_01490	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynMITS9220_01493	COG0271	Belongs to the BolA IbaG family
SynMITS9220_01494	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynMITS9220_01497	COG0745	RESPONSE REGULATOR receiver
SynMITS9220_01500	COG0076	glutamate decarboxylase activity
SynMITS9220_01501	COG2095	MarC family integral membrane protein
SynMITS9220_01504	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynMITS9220_01509	COG0745	RESPONSE REGULATOR receiver
SynMITS9220_01517	COG0735	belongs to the Fur family
SynMITS9220_01519	COG1799	cell septum assembly
SynMITS9220_01523	COG0625	glutathione transferase activity
SynMITS9220_01550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynMITS9220_01556	COG1217	gtp-binding protein TYPA
SynMITS9220_01558	COG0644	oxidoreductase
SynMITS9220_01559	COG0751	glycine-tRNA ligase activity
SynMITS9220_01560	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynMITS9220_01561	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynMITS9220_01562	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynMITS9220_01564	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynMITS9220_01565	COG0052	Belongs to the universal ribosomal protein uS2 family
SynMITS9220_01566	COG1216	Glycosyl transferase, family 2
SynMITS9220_01572	COG0612	Peptidase, M16
SynMITS9220_01576	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynMITS9220_01577	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SynMITS9220_01580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynMITS9220_01582	COG0174	glutamine synthetase
SynMITS9220_01595	COG2226	methyltransferase
SynMITS9220_01600	COG0515	serine threonine protein kinase
SynMITS9220_01601	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynMITS9220_01603	COG0628	permease
SynMITS9220_01608	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynMITS9220_01609	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynMITS9220_01610	COG0022	dehydrogenase e1 component
SynMITS9220_01610	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynMITS9220_01613	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynMITS9220_01614	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynMITS9220_01619	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynMITS9220_01622	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynMITS9220_01648	COG1028	Short-chain dehydrogenase reductase Sdr
SynMITS9220_01649	COG0358	DNA primase activity
SynMITS9220_01658	COG0632	four-way junction helicase activity
SynMITS9220_01659	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynMITS9220_01661	COG0587	DNA-directed DNA polymerase activity
SynMITS9220_01662	COG0154	amidase activity
SynMITS9220_01664	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynMITS9220_01665	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynMITS9220_01667	COG0505	Belongs to the CarA family
SynMITS9220_01668	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynMITS9220_01669	COG1132	(ABC) transporter
SynMITS9220_01671	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynMITS9220_01675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMITS9220_01679	COG2176	DNA-directed DNA polymerase activity
SynMITS9220_01680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynMITS9220_01684	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynMITS9220_01688	COG0142	geranyltranstransferase activity
SynMITS9220_01689	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynMITS9220_01690	COG0860	N-Acetylmuramoyl-L-alanine amidase
SynMITS9220_01692	COG2045	Belongs to the ComB family
SynMITS9220_01693	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynMITS9220_01694	COG1840	ABC-type Fe3 transport system, periplasmic component
SynMITS9220_01695	COG3128	pkhd-type hydroxylase
SynMITS9220_01698	COG3659	wide pore channel activity
SynMITS9220_01701	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynMITS9220_01705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynMITS9220_01706	COG1803	Methylglyoxal synthase
SynMITS9220_01706	COG1597	lipid kinase activity
SynMITS9220_01709	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynMITS9220_01711	COG0297	glycogen (starch) synthase activity
SynMITS9220_01712	COG1376	ErfK ybiS ycfS ynhG family protein
SynMITS9220_01713	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynMITS9220_01714	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynMITS9220_01716	COG0681	Belongs to the peptidase S26 family
SynMITS9220_01730	COG0590	tRNA wobble adenosine to inosine editing
SynMITS9220_01774	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynMITS9220_01775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynMITS9220_01776	COG1121	(ABC) transporter
SynMITS9220_01779	COG0701	Predicted permease
SynMITS9220_01784	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynMITS9220_01785	COG1121	(ABC) transporter
SynMITS9220_01875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynMITS9220_01877	COG0300	oxidoreductase activity
SynMITS9220_01886	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMITS9220_01890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynMITS9220_01922	COG0405	Gamma-glutamyltransferase
SynMITS9220_01940	COG2720	vancomycin resistance protein
SynMITS9220_01942	COG0523	cobalamin synthesis protein
SynMITS9220_01944	COG1121	(ABC) transporter
SynMITS9220_01945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynMITS9220_01946	COG2124	cytochrome p450
SynMITS9220_02008	COG2135	peptidase activity
SynMITS9220_02015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynMITS9220_02031	COG3781	membrane
SynMITS9220_02059	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynMITS9220_02060	COG0351	phosphomethylpyrimidine kinase
SynMITS9220_02068	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynMITS9220_02078	COG0180	Tryptophanyl-tRNA synthetase
SynMITS9220_02084	COG0837	glucose binding
SynMITS9220_02085	COG0083	homoserine kinase activity
SynMITS9220_02086	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMITS9220_02087	COG0339	signal peptide processing
SynMITS9220_02093	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SynMITS9220_02094	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynMITS9220_02102	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynMITS9220_02103	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynMITS9220_02105	COG3794	PFAM blue (type 1) copper domain protein
SynMITS9220_02119	COG0542	response to heat
SynMITS9220_02121	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynMITS9220_02121	COG0140	phosphoribosyl-ATP diphosphatase activity
SynMITS9220_02122	COG1376	ErfK ybiS ycfS ynhG family protein
SynMITS9220_02126	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMITS9220_02132	COG2010	Cytochrome c
SynMITS9220_02135	COG0159	tryptophan synthase activity
SynMITS9220_02140	COG0418	dihydroorotase activity
SynMITS9220_02141	COG0659	secondary active sulfate transmembrane transporter activity
SynMITS9220_02142	COG0530	calcium, potassium:sodium antiporter activity
SynMITS9220_02146	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynMITS9220_02149	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynMITS9220_02152	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynMITS9220_02153	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMITS9220_02156	COG0456	acetyltransferase
SynMITS9220_02157	COG0596	Alpha beta hydrolase
SynMITS9220_02158	COG1132	(ABC) transporter
SynMITS9220_02159	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynMITS9220_02160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynMITS9220_02162	COG0251	oxidation-reduction process
SynMITS9220_02167	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMITS9220_02168	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynMITS9220_02169	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynMITS9220_02174	COG4451	ribulose bisphosphate carboxylase, small
SynMITS9220_02175	COG1850	ribulose-bisphosphate carboxylase activity
SynMITS9220_02176	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynMITS9220_02178	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynMITS9220_02179	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynMITS9220_02182	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynMITS9220_02183	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynMITS9220_02185	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynMITS9220_02192	COG0730	response to heat
SynMITS9220_02193	COG0095	Lipoate-protein ligase
SynMITS9220_02194	COG1994	Peptidase M50
SynMITS9220_02194	COG0517	IMP dehydrogenase activity
SynMITS9220_02195	COG0135	phosphoribosylanthranilate isomerase activity
SynMITS9220_02197	COG0302	gtp cyclohydrolase
SynMITS9220_02198	COG1028	Short-chain dehydrogenase reductase Sdr
SynMITS9220_02199	COG0825	malonyl-CoA metabolic process
SynMITS9220_02200	COG5322	oxidoreductase activity
SynMITS9220_02202	COG3396	Phenylacetate-CoA oxygenase
SynMITS9220_02204	COG0539	negative regulation of cytoplasmic translation
SynMITS9220_02207	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynMITS9220_02210	COG0028	Belongs to the TPP enzyme family
SynMITS9220_02211	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMITS9220_02214	COG2226	methyltransferase
SynMITS9220_02217	COG0528	UMP kinase activity
SynMITS9220_02218	COG0233	cytoplasmic translational termination
SynMITS9220_02219	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
SynMITS9220_02220	COG0415	Belongs to the DNA photolyase family
SynMITS9220_02222	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynMITS9220_02223	COG0768	penicillin binding
SynMITS9220_02228	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SynMITS9220_02229	COG0681	Belongs to the peptidase S26 family
SynMITS9220_02233	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynMITS9220_02236	COG0442	prolyl-tRNA aminoacylation
SynMITS9220_02238	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynMITS9220_02239	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynMITS9220_02240	COG2099	Precorrin-6x reductase
SynMITS9220_02241	COG0629	single-stranded DNA binding
SynMITS9220_02244	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynMITS9220_02246	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynMITS9220_02248	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMITS9220_02250	COG0181	hydroxymethylbilane synthase activity
SynMITS9220_02253	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynMITS9220_02254	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynMITS9220_02258	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynMITS9220_02259	COG0523	cobalamin synthesis protein
SynMITS9220_02264	COG1230	cation diffusion facilitator family transporter
SynMITS9220_02266	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynMITS9220_02272	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynMITS9220_02274	COG1666	GTP binding
SynMITS9220_02276	COG0330	HflC and HflK could
SynMITS9220_02279	COG0857	belongs to the CobB CobQ family
SynMITS9220_02282	COG0300	oxidoreductase activity
SynMITS9220_02282	COG3000	fatty acid hydroxylase
SynMITS9220_02283	COG0024	Methionine aminopeptidase
SynMITS9220_02285	COG0335	large ribosomal subunit rRNA binding
SynMITS9220_02291	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynMITS9220_02292	COG3263	regulation of cellular component size
SynMITS9220_02295	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynMITS9220_02297	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMITS9220_02298	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynMITS9220_02301	COG0194	GDP metabolic process
SynMITS9220_02303	COG0805	protein transport
SynMITS9220_02305	COG0723	plastoquinol--plastocyanin reductase activity
SynMITS9220_02306	COG0739	heme binding
SynMITS9220_02307	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynMITS9220_02316	COG0248	Ppx GppA phosphatase
SynMITS9220_02317	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynMITS9220_02318	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynMITS9220_02319	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynMITS9220_02321	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynMITS9220_02322	COG1028	Short-chain dehydrogenase reductase Sdr
SynMITS9220_02324	COG0459	protein refolding
SynMITS9220_02326	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynMITS9220_02330	COG0109	protoheme IX farnesyltransferase activity
SynMITS9220_02331	COG1612	heme a metabolic process
SynMITS9220_02334	COG1845	cytochrome c oxidase, subunit III
SynMITS9220_02343	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynMITS9220_02346	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynMITS9220_02348	COG1007	ATP synthesis coupled electron transport
SynMITS9220_02349	COG0577	efflux transmembrane transporter activity
SynMITS9220_02349	COG1136	(ABC) transporter
SynMITS9220_02350	COG0745	RESPONSE REGULATOR receiver
SynMITS9220_02351	COG0739	heme binding
SynMITS9220_02352	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynMITS9220_02352	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynMITS9220_02353	COG0436	Aminotransferase
SynMITS9220_02354	COG1842	Phage shock protein A
SynMITS9220_02356	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynMITS9220_02358	COG0697	spore germination
SynMITS9220_02359	COG0616	signal peptide processing
SynMITS9220_02363	COG0594	ribonuclease P activity
SynMITS9220_02365	COG0706	membrane insertase activity
SynMITS9220_02367	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMITS9220_02369	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynMITS9220_02370	COG0750	zinc metalloprotease
SynMITS9220_02371	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynMITS9220_02372	COG1185	polyribonucleotide nucleotidyltransferase activity
SynMITS9220_02374	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynMITS9220_02383	COG1525	nuclease
SynMITS9220_02411	COG1970	mechanosensitive ion channel activity
SynMITS9220_02413	COG0625	glutathione transferase activity
SynMITS9220_02451	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynMITS9220_02452	COG0776	regulation of translation
SynMITS9220_02456	COG2211	Major facilitator Superfamily
SynMITS9220_02457	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynMITS9220_02460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynMITS9220_02461	COG0284	orotidine-5'-phosphate decarboxylase activity
SynMITS9220_02462	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynMITS9220_02467	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynMITS9220_02470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynMITS9220_02470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynMITS9220_02471	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynMITS9220_02472	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynMITS9220_02473	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynMITS9220_02474	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynMITS9220_02476	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynMITS9220_02478	COG0151	Belongs to the GarS family
SynMITS9220_02479	COG5002	protein histidine kinase activity
SynMITS9220_02480	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynMITS9220_02481	COG4251	negative regulation of phosphorylation
SynMITS9220_02483	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynMITS9220_02484	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynMITS9220_02486	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynMITS9220_02487	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynMITS9220_02489	COG0363	glucosamine-6-phosphate deaminase activity
SynMITS9220_02490	COG2385	sporulation resulting in formation of a cellular spore
SynMITS9220_02491	COG1234	tRNA 3'-trailer cleavage
SynMITS9220_02492	COG2010	Cytochrome c
SynMITS9220_02495	COG2264	protein methyltransferase activity
SynMITS9220_02496	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynMITS9220_02500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynMITS9220_02507	COG0443	Heat shock 70 kDa protein
SynMITS9220_02509	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynMITS9220_02512	COG0004	ammonium transporteR
SynMITS9220_02513	COG0459	protein refolding
SynMITS9220_02514	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynMITS9220_02515	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynMITS9220_02516	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynMITS9220_02519	COG0739	heme binding
SynMITS9220_02523	COG0006	proline dipeptidase activity
SynMITS9220_02524	COG1253	flavin adenine dinucleotide binding
SynMITS9220_02525	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynMITS9220_02526	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynMITS9220_02527	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynMITS9220_02527	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynMITS9220_02529	COG3012	SEC-C Motif Domain Protein
SynMITS9220_02530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynMITS9220_02533	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynMITS9220_02535	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynMITS9220_02536	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynMITS9220_02537	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynMITS9220_02538	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynMITS9220_02539	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynMITS9220_02540	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynMITS9220_02541	COG0356	it plays a direct role in the translocation of protons across the membrane
SynMITS9220_02543	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynMITS9220_02544	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMITS9220_02548	COG0772	Belongs to the SEDS family
SynMITS9220_02550	COG1333	cytochrome c biogenesis protein
SynMITS9220_02551	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynMITS9220_02554	COG0347	Belongs to the P(II) protein family
SynMITS9220_02557	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynMITS9220_02558	COG0114	fumarate hydratase activity
SynMITS9220_02559	COG4581	dead DEAH box helicase
SynMITS9220_02560	COG0156	8-amino-7-oxononanoate synthase activity
SynMITS9220_02563	COG4106	trans-aconitate 2-methyltransferase activity
SynMITS9220_02563	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynMITS9220_02566	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynMITS9220_02569	COG0357	Ribosomal RNA small subunit methyltransferase G
SynMITS9220_02576	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SynMITS9220_02577	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynMITS9220_02578	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMITS9220_02579	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynMITS9220_02580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynMITS9220_02581	COG0085	RNA polymerase activity
SynMITS9220_02583	COG0084	hydrolase, TatD family'
SynMITS9220_02584	COG0268	Binds directly to 16S ribosomal RNA
SynMITS9220_02585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynMITS9220_02586	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynMITS9220_02587	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMITS9220_02590	COG0641	radical SAM
SynMITS9220_02591	COG0779	Required for maturation of 30S ribosomal subunits
SynMITS9220_02592	COG0195	Participates in both transcription termination and antitermination
SynMITS9220_02594	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynMITS9220_02611	COG2988	succinylglutamate desuccinylase activity
SynMITS9220_02612	COG0435	Glutathione S-transferase
SynMITS9220_02614	COG0488	(ABC) transporter
SynMITS9220_02618	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynMITS9220_02619	COG3842	ATPase activity
SynMITS9220_02620	COG1193	negative regulation of DNA recombination
SynMITS9220_02623	COG0113	porphobilinogen synthase activity
SynMITS9220_02624	COG0484	heat shock protein binding
SynMITS9220_02626	COG0659	secondary active sulfate transmembrane transporter activity
SynMITS9220_02629	COG0716	FMN binding
SynMITS9220_02630	COG0492	ferredoxin-NADP+ reductase activity
SynMITS9220_02642	COG2197	response regulator
SynMITS9220_02652	COG0116	Belongs to the methyltransferase superfamily
SynMITS9220_02656	COG1196	nuclear chromosome segregation
SynMITS9220_02658	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynMITS9220_02659	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynMITS9220_02661	COG0439	Biotin carboxylase
SynMITS9220_02664	COG0515	serine threonine protein kinase
SynMITS9220_02668	COG4178	(ABC) transporter
SynMITS9220_02669	COG0537	adenosine 5'-monophosphoramidase activity
SynMITS9220_02673	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynMITS9220_02676	COG0242	peptide deformylase activity
SynMITS9220_02679	COG0235	Class ii aldolase
SynMITS9220_02680	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynMITS9220_02681	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynMITS9220_02682	COG0719	Fe-S assembly protein
SynMITS9220_02683	COG0396	ATPase activity
SynMITS9220_02684	COG0719	Fe-S assembly protein
SynMITS9220_02691	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMITS9220_02706	COG0033	Phosphoglucomutase
SynMITS9220_02708	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynMITS9220_02710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SynMITS9220_02713	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynMITS9220_02714	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynMITS9220_02715	COG0175	sulfate reduction
SynMITS9220_02716	COG1252	NADH dehydrogenase
SynMITS9220_02717	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynMITS9220_02718	COG0471	metal ion transport
SynMITS9220_02718	COG3273	potassium ion transport
SynMITS9220_02719	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynMITS9220_02720	COG0569	domain protein
SynMITS9220_02721	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynMITS9220_02726	COG0488	(ABC) transporter
SynMITS9220_02728	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMITS9220_02732	COG1643	Atp-dependent helicase
SynMITS9220_02733	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMITS9220_02735	COG1570	exodeoxyribonuclease VII activity
SynMITS9220_02746	COG0483	inositol monophosphate 1-phosphatase activity
SynMITS9220_02747	COG1538	Outer membrane efflux protein
SynMITS9220_02749	COG1968	undecaprenyl-diphosphatase activity
SynMITS9220_02751	COG1555	photosystem II stabilization
SynMITS9220_02752	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynMITS9220_02753	COG4243	Vitamin k epoxide reductase
SynMITS9220_02754	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynMITS9220_02756	COG1032	radical SAM domain protein
SynMITS9220_02762	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynMITS9220_02767	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynMITS9220_02769	COG0463	Glycosyl transferase, family 2
SynMITS9220_02769	COG0457	Tetratricopeptide repeat
SynMITS9220_02770	COG1587	Uroporphyrinogen-III synthase
SynMITS9220_02773	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynMITS9220_02774	COG0316	Belongs to the HesB IscA family
SynMITS9220_02777	COG1090	epimerase
SynMITS9220_02778	COG3263	regulation of cellular component size
SynMITS9220_02781	COG0484	heat shock protein binding
SynMITS9220_02782	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynMITS9220_02783	COG3659	wide pore channel activity
SynMITS9220_02785	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynMITS9220_02793	COG1122	ATPase activity
SynMITS9220_02796	COG0745	RESPONSE REGULATOR receiver
SynMITS9220_02798	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynMITS9220_02799	COG2217	Heavy metal translocating P-type atpase
SynMITS9220_02800	COG3063	Type IV pilus biogenesis stability protein PilW
SynMITS9220_02801	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynMITS9220_02803	COG0416	fatty acid biosynthetic process
SynMITS9220_02804	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynMITS9220_02805	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynMITS9220_02806	COG0204	Acyl-transferase
SynMITS9220_02806	COG0318	PFAM AMP-dependent synthetase and ligase
SynMITS9220_02808	COG1214	PFAM Peptidase M22, glycoprotease
SynMITS9220_02810	COG0617	tRNA 3'-terminal CCA addition
SynMITS9220_02812	COG1562	ergosterol biosynthetic process
SynMITS9220_02813	COG0493	'glutamate synthase
SynMITS9220_02813	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynMITS9220_02817	COG0583	DNA-binding transcription factor activity
SynMITS9220_02819	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynMITS9220_02821	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMITS9220_02823	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynMITS9220_02825	COG2197	response regulator
SynMITS9220_02828	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynMITS9220_02829	COG0713	ATP synthesis coupled electron transport
SynMITS9220_02830	COG0839	Belongs to the complex I subunit 6 family
SynMITS9220_02831	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMITS9220_02832	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynMITS9220_02833	COG0372	Belongs to the citrate synthase family
SynMITS9220_02837	COG1420	regulation of RNA biosynthetic process
SynMITS9220_02838	COG0133	tryptophan synthase activity
SynMITS9220_02839	COG2226	methyltransferase
SynMITS9220_02840	COG0023	Translation Initiation Factor
SynMITS9220_02841	COG0529	Catalyzes the synthesis of activated sulfate
SynMITS9220_02842	COG0628	permease
SynMITS9220_02843	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynMITS9220_02844	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SynMITS9220_02845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynMITS9220_02847	COG0564	pseudouridine synthase activity
SynMITS9220_02848	COG0745	RESPONSE REGULATOR receiver
SynMITS9220_02850	COG1104	cysteine desulfurase activity
SynMITS9220_02853	COG0275	rRNA processing
SynMITS9220_02854	COG0649	NAD binding
SynMITS9220_02862	COG0824	Thioesterase
SynMITS9220_02866	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMITS9220_02871	COG1575	Belongs to the MenA family. Type 1 subfamily
SynMITS9220_02873	COG0189	ligase activity
SynMITS9220_02874	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynMITS9220_02876	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynMITS9220_02878	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynMITS9220_02879	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynMITS9220_02880	COG0512	Glutamine amidotransferase of anthranilate synthase
SynMITS9220_02882	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynMITS9220_02884	COG0252	asparaginase activity
SynMITS9220_02885	COG0018	arginyl-trna synthetase
SynMITS9220_02886	COG0157	Belongs to the NadC ModD family
SynMITS9220_02887	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynMITS9220_02890	COG2226	methyltransferase
SynMITS9220_02891	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMITS9220_02892	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynMITS9220_02893	COG4172	Belongs to the ABC transporter superfamily
SynMITS9220_02896	COG0564	pseudouridine synthase activity
SynMITS9220_02898	COG0589	response to stress
SynMITS9220_02899	COG0126	phosphoglycerate kinase activity
SynMITS9220_02903	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynMITS9220_02904	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynMITS9220_02910	COG0167	dihydroorotate dehydrogenase activity
SynMITS9220_02911	COG0328	RNA-DNA hybrid ribonuclease activity
SynMITS9220_02914	COG0222	ribosome binding
SynMITS9220_02915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynMITS9220_02916	COG0081	regulation of translation
SynMITS9220_02917	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynMITS9220_02918	COG0250	Participates in transcription elongation, termination and antitermination
SynMITS9220_02919	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynMITS9220_02920	COG0542	response to heat
SynMITS9220_02921	COG0346	lactoylglutathione lyase activity
SynMITS9220_02923	COG0148	phosphopyruvate hydratase activity
SynMITS9220_02925	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynMITS9220_02928	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynMITS9220_02929	COG0237	dephospho-CoA kinase activity
SynMITS9220_02933	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynMITS9220_02934	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynMITS9220_02934	COG2022	thiamine diphosphate biosynthetic process
SynMITS9220_02938	COG0105	UTP biosynthetic process
SynMITS9220_02940	COG1166	arginine decarboxylase activity
SynMITS9220_02942	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMITS9220_02951	COG1803	Methylglyoxal synthase
SynMITS9220_02957	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynMITS9220_02959	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynMITS9220_02963	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SynMITS9220_02965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SynMITS9220_02966	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynMITS9220_02966	COG0426	domain, Protein
SynMITS9220_02969	COG0426	domain, Protein
SynMITS9220_02969	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynMITS9220_02974	COG0509	glycine decarboxylation via glycine cleavage system
SynMITS9220_02975	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynMITS9220_02979	COG0359	binds to the 23S rRNA
SynMITS9220_02980	COG1372	Participates in initiation and elongation during chromosome replication
SynMITS9220_02980	COG0305	Participates in initiation and elongation during chromosome replication
SynMITS9220_02980	COG0305	Participates in initiation and elongation during chromosome replication
SynMITS9220_02980	COG1372	Participates in initiation and elongation during chromosome replication
SynMITS9220_02983	COG0445	tRNA wobble uridine modification
SynMITS9220_02991	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynMITS9220_02994	COG0398	Pfam SNARE associated Golgi protein
SynMITS9220_02997	COG0668	transmembrane transport
SynMITS9220_02998	COG0668	transmembrane transport
SynMITS9220_03001	COG1131	(ABC) transporter
SynMITS9220_03002	COG0525	valine-tRNA ligase activity
SynMITS9220_03004	COG3264	Mechanosensitive ion channel
SynMITS9220_03004	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SynMITS9220_03008	COG4221	oxidoreductase activity
SynMITS9220_03015	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMITS9220_03023	COG3956	TIGRFAM MazG family protein
SynMITS9220_03026	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynMITS9220_03032	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynMITS9220_03033	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynMITS9220_03034	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMITS9220_03035	COG0783	Belongs to the Dps family
SynMITS9220_03036	COG0504	CTP synthase activity
SynMITS9220_03037	COG0602	queuosine metabolic process
SynMITS9220_03040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SynMITS9220_03043	COG4574	serine-type endopeptidase inhibitor activity
SynMITS9220_03044	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynMITS9220_03050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynMITS9220_03052	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynMITS9220_03054	COG2116	formate transmembrane transporter activity
SynMITS9220_03056	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynMITS9220_03059	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynMITS9220_03062	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynMITS9220_03063	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMITS9220_03064	COG0170	dolichyl monophosphate biosynthetic process
SynMITS9220_03065	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynMITS9220_03066	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynMITS9220_03069	COG0788	formyltetrahydrofolate deformylase activity
SynMITS9220_03072	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynMITS9220_03074	COG0443	Heat shock 70 kDa protein
SynMITS9220_03075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynMITS9220_03077	COG0360	Binds together with S18 to 16S ribosomal RNA
SynMITS9220_03079	COG0137	argininosuccinate synthase activity
SynMITS9220_03082	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynMITS9220_03085	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynMITS9220_03086	COG0438	transferase activity, transferring glycosyl groups
SynMITS9220_03089	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynMITS9220_03090	COG0497	DNA recombination
SynMITS9220_03091	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynMITS9220_03093	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SynMITS9220_50014	COG0217	transcriptional regulatory protein