locus-tag	class	description
SynMINOS11_00001	COG0592	DNA-directed DNA polymerase activity
SynMINOS11_00003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynMINOS11_00004	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynMINOS11_00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynMINOS11_00007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynMINOS11_00010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynMINOS11_00011	COG0552	protein localization to endoplasmic reticulum
SynMINOS11_00012	COG2208	phosphoserine phosphatase activity
SynMINOS11_00013	COG0165	Argininosuccinate lyase
SynMINOS11_00014	COG0724	RNA recognition motif
SynMINOS11_00015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynMINOS11_00017	COG2081	HI0933 family
SynMINOS11_00018	COG1459	type II secretion system
SynMINOS11_00020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynMINOS11_00021	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynMINOS11_00022	COG0484	heat shock protein binding
SynMINOS11_00025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynMINOS11_00026	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynMINOS11_00027	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynMINOS11_00028	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynMINOS11_00029	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynMINOS11_00030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynMINOS11_00031	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynMINOS11_00032	COG0511	ligase activity, forming carbon-carbon bonds
SynMINOS11_00033	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynMINOS11_00039	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynMINOS11_00044	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynMINOS11_00052	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynMINOS11_00052	COG0519	Catalyzes the synthesis of GMP from XMP
SynMINOS11_00057	COG0768	penicillin binding
SynMINOS11_00058	COG0438	transferase activity, transferring glycosyl groups
SynMINOS11_00058	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynMINOS11_00059	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynMINOS11_00061	COG2022	thiamine diphosphate biosynthetic process
SynMINOS11_00064	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynMINOS11_00065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynMINOS11_00066	COG2385	sporulation resulting in formation of a cellular spore
SynMINOS11_00067	COG1215	transferase activity, transferring glycosyl groups
SynMINOS11_00068	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynMINOS11_00070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynMINOS11_00071	COG0740	serine-type endopeptidase activity
SynMINOS11_00072	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynMINOS11_00073	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynMINOS11_00074	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynMINOS11_00075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynMINOS11_00077	COG0037	tRNA processing
SynMINOS11_00079	COG0556	nucleotide-excision repair
SynMINOS11_00080	COG0527	aspartate kinase activity
SynMINOS11_00082	COG2082	Precorrin-8x methylmutase
SynMINOS11_00083	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynMINOS11_00085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynMINOS11_00091	COG0454	-acetyltransferase
SynMINOS11_00092	COG0653	protein targeting
SynMINOS11_00093	COG1045	serine acetyltransferase
SynMINOS11_00094	COG1725	Transcriptional regulator
SynMINOS11_00095	COG0412	Dienelactone hydrolase
SynMINOS11_00096	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynMINOS11_00097	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynMINOS11_00098	COG0187	DNA topoisomerase II activity
SynMINOS11_00098	COG1372	Participates in initiation and elongation during chromosome replication
SynMINOS11_00100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynMINOS11_00101	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynMINOS11_00102	COG0386	Belongs to the glutathione peroxidase family
SynMINOS11_00103	COG2239	Acts as a magnesium transporter
SynMINOS11_00104	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_00108	COG0802	atpase or kinase
SynMINOS11_00109	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynMINOS11_00110	COG0586	Pfam SNARE associated Golgi protein
SynMINOS11_00111	COG0629	single-stranded DNA binding
SynMINOS11_00116	COG0745	RESPONSE REGULATOR receiver
SynMINOS11_00117	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynMINOS11_00123	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynMINOS11_00124	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynMINOS11_00126	COG0515	serine threonine protein kinase
SynMINOS11_00127	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynMINOS11_00128	COG2255	four-way junction helicase activity
SynMINOS11_00130	COG1473	amidohydrolase
SynMINOS11_00133	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynMINOS11_00134	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynMINOS11_00135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynMINOS11_00136	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynMINOS11_00137	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_00138	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynMINOS11_00139	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynMINOS11_00141	COG0571	ribonuclease III activity
SynMINOS11_00142	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SynMINOS11_00142	COG2755	lipolytic protein G-D-S-L family
SynMINOS11_00147	COG0058	SHG alpha-glucan phosphorylase activity
SynMINOS11_00152	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SynMINOS11_00152	COG2755	lipolytic protein G-D-S-L family
SynMINOS11_00153	COG0277	FAD linked oxidase domain protein
SynMINOS11_00155	COG0247	lactate metabolic process
SynMINOS11_00156	COG2192	nodulation
SynMINOS11_00160	COG0538	isocitrate dehydrogenase activity
SynMINOS11_00162	COG5398	heme oxygenase
SynMINOS11_00164	COG1132	(ABC) transporter
SynMINOS11_00165	COG0124	histidyl-tRNA synthetase
SynMINOS11_00166	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynMINOS11_00167	COG0709	Synthesizes selenophosphate from selenide and ATP
SynMINOS11_00171	COG0617	tRNA 3'-terminal CCA addition
SynMINOS11_00179	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynMINOS11_00180	COG0438	transferase activity, transferring glycosyl groups
SynMINOS11_00181	COG0367	asparagine synthase
SynMINOS11_00184	COG0463	Glycosyl transferase, family 2
SynMINOS11_00194	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynMINOS11_00195	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynMINOS11_00196	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynMINOS11_00197	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynMINOS11_00200	COG1083	cytidylyl-transferase
SynMINOS11_00201	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynMINOS11_00211	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SynMINOS11_00220	COG1063	alcohol dehydrogenase
SynMINOS11_00221	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SynMINOS11_00227	COG4447	cellulose binding
SynMINOS11_00228	COG1773	rubredoxin
SynMINOS11_00229	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_00230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_00231	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_00233	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynMINOS11_00234	COG3842	ATPase activity
SynMINOS11_00236	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynMINOS11_00236	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynMINOS11_00239	COG0494	nUDIX hydrolase
SynMINOS11_00240	COG0415	Belongs to the DNA photolyase family
SynMINOS11_00241	COG2197	response regulator
SynMINOS11_00243	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynMINOS11_00246	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_00247	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynMINOS11_00249	COG0583	DNA-binding transcription factor activity
SynMINOS11_00252	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynMINOS11_00252	COG0493	'glutamate synthase
SynMINOS11_00253	COG1562	ergosterol biosynthetic process
SynMINOS11_00256	COG0617	tRNA 3'-terminal CCA addition
SynMINOS11_00258	COG1214	PFAM Peptidase M22, glycoprotease
SynMINOS11_00261	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynMINOS11_00262	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynMINOS11_00263	COG0416	fatty acid biosynthetic process
SynMINOS11_00264	COG0745	RESPONSE REGULATOR receiver
SynMINOS11_00265	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynMINOS11_00266	COG0457	Tetratricopeptide repeat
SynMINOS11_00267	COG2217	Heavy metal translocating P-type atpase
SynMINOS11_00268	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynMINOS11_00269	COG0470	DNA polymerase III
SynMINOS11_00270	COG0745	RESPONSE REGULATOR receiver
SynMINOS11_00272	COG1122	ATPase activity
SynMINOS11_00280	COG3659	wide pore channel activity
SynMINOS11_00280	COG3659	wide pore channel activity
SynMINOS11_00281	COG3659	wide pore channel activity
SynMINOS11_00281	COG3659	wide pore channel activity
SynMINOS11_00282	COG0457	Tetratricopeptide repeat
SynMINOS11_00282	COG0859	PFAM glycosyl transferase family 9
SynMINOS11_00283	COG0859	PFAM glycosyl transferase family 9
SynMINOS11_00283	COG0457	Tetratricopeptide repeat
SynMINOS11_00284	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynMINOS11_00285	COG0484	heat shock protein binding
SynMINOS11_00287	COG1090	epimerase
SynMINOS11_00291	COG0316	Belongs to the HesB IscA family
SynMINOS11_00292	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynMINOS11_00295	COG1587	Uroporphyrinogen-III synthase
SynMINOS11_00296	COG0463	Glycosyl transferase, family 2
SynMINOS11_00296	COG0457	Tetratricopeptide repeat
SynMINOS11_00297	COG1472	Belongs to the glycosyl hydrolase 3 family
SynMINOS11_00298	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynMINOS11_00301	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SynMINOS11_00301	COG0517	IMP dehydrogenase activity
SynMINOS11_00302	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynMINOS11_00303	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynMINOS11_00304	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynMINOS11_00309	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynMINOS11_00315	COG1032	radical SAM domain protein
SynMINOS11_00318	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynMINOS11_00319	COG0434	BtpA family
SynMINOS11_00320	COG4243	Vitamin k epoxide reductase
SynMINOS11_00321	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynMINOS11_00322	COG1555	photosystem II stabilization
SynMINOS11_00324	COG1968	undecaprenyl-diphosphatase activity
SynMINOS11_00327	COG2211	Major facilitator Superfamily
SynMINOS11_00328	COG0483	inositol monophosphate 1-phosphatase activity
SynMINOS11_00329	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynMINOS11_00331	COG1193	negative regulation of DNA recombination
SynMINOS11_00333	COG0113	porphobilinogen synthase activity
SynMINOS11_00334	COG0484	heat shock protein binding
SynMINOS11_00357	COG0116	Belongs to the methyltransferase superfamily
SynMINOS11_00360	COG1196	nuclear chromosome segregation
SynMINOS11_00362	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynMINOS11_00365	COG0439	Biotin carboxylase
SynMINOS11_00368	COG0515	serine threonine protein kinase
SynMINOS11_00371	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMINOS11_00372	COG4178	(ABC) transporter
SynMINOS11_00373	COG0537	adenosine 5'-monophosphoramidase activity
SynMINOS11_00377	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynMINOS11_00380	COG0242	peptide deformylase activity
SynMINOS11_00382	COG2988	succinylglutamate desuccinylase activity
SynMINOS11_00399	COG1570	exodeoxyribonuclease VII activity
SynMINOS11_00401	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMINOS11_00406	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMINOS11_00411	COG0488	(ABC) transporter
SynMINOS11_00418	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynMINOS11_00419	COG0450	alkyl hydroperoxide reductase
SynMINOS11_00420	COG0438	transferase activity, transferring glycosyl groups
SynMINOS11_00421	COG0546	phosphoglycolate phosphatase activity
SynMINOS11_00422	COG1252	NADH dehydrogenase
SynMINOS11_00423	COG0175	sulfate reduction
SynMINOS11_00424	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynMINOS11_00425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynMINOS11_00432	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMINOS11_00433	COG0033	Phosphoglucomutase
SynMINOS11_00436	COG3394	polysaccharide catabolic process
SynMINOS11_00437	COG0463	Glycosyl transferase, family 2
SynMINOS11_00439	COG0659	secondary active sulfate transmembrane transporter activity
SynMINOS11_00440	COG0418	dihydroorotase activity
SynMINOS11_00444	COG1070	Carbohydrate kinase
SynMINOS11_00445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynMINOS11_00447	COG0539	negative regulation of cytoplasmic translation
SynMINOS11_00448	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynMINOS11_00452	COG0589	response to stress
SynMINOS11_00453	COG0824	Thioesterase
SynMINOS11_00454	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynMINOS11_00454	COG0758	DNA mediated transformation
SynMINOS11_00455	COG2890	protein-(glutamine-N5) methyltransferase activity
SynMINOS11_00456	COG0009	L-threonylcarbamoyladenylate synthase
SynMINOS11_00457	COG0798	PFAM Bile acid sodium symporter
SynMINOS11_00459	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynMINOS11_00460	COG0640	Transcriptional regulator
SynMINOS11_00462	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_00468	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynMINOS11_00469	COG2894	cell division
SynMINOS11_00470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SynMINOS11_00473	COG0850	regulation of cytokinetic process
SynMINOS11_00474	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
SynMINOS11_00475	COG1078	dGTPase activity
SynMINOS11_00476	COG0793	Belongs to the peptidase S41A family
SynMINOS11_00477	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynMINOS11_00478	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynMINOS11_00480	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynMINOS11_00481	COG0235	Class ii aldolase
SynMINOS11_00482	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynMINOS11_00485	COG0514	ATP-dependent DNA helicase (RecQ)
SynMINOS11_00487	COG1012	belongs to the aldehyde dehydrogenase family
SynMINOS11_00490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynMINOS11_00493	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynMINOS11_00496	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynMINOS11_00499	COG1376	ErfK ybiS ycfS ynhG family protein
SynMINOS11_00501	COG1160	GTP binding
SynMINOS11_00502	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynMINOS11_00504	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynMINOS11_00505	COG1799	cell septum assembly
SynMINOS11_00506	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynMINOS11_00507	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynMINOS11_00510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynMINOS11_00511	COG2211	Major facilitator Superfamily
SynMINOS11_00515	COG0776	regulation of translation
SynMINOS11_00522	COG2274	protein secretion by the type I secretion system
SynMINOS11_00524	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SynMINOS11_00560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMINOS11_00590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynMINOS11_00591	COG1218	3'(2'),5'-bisphosphate nucleotidase
SynMINOS11_00592	COG1185	polyribonucleotide nucleotidyltransferase activity
SynMINOS11_00593	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SynMINOS11_00594	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynMINOS11_00595	COG0750	zinc metalloprotease
SynMINOS11_00596	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynMINOS11_00597	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynMINOS11_00598	COG0579	oxidoreductase
SynMINOS11_00600	COG0371	Dehydrogenase
SynMINOS11_00601	COG0481	GTPase activity
SynMINOS11_00613	COG0745	RESPONSE REGULATOR receiver
SynMINOS11_00615	COG2205	protein histidine kinase activity
SynMINOS11_00618	COG5002	protein histidine kinase activity
SynMINOS11_00619	COG1450	Type ii and iii secretion system protein
SynMINOS11_00626	COG4968	Prepilin-type N-terminal cleavage methylation domain
SynMINOS11_00632	COG4968	Prepilin-type N-terminal cleavage methylation domain
SynMINOS11_00636	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynMINOS11_00638	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynMINOS11_00638	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynMINOS11_00640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynMINOS11_00641	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynMINOS11_00643	COG0107	imidazoleglycerol-phosphate synthase activity
SynMINOS11_00645	COG2226	methyltransferase
SynMINOS11_00647	COG2132	Multicopper oxidase
SynMINOS11_00650	COG0752	glycyl-tRNA synthetase alpha subunit
SynMINOS11_00656	COG0438	transferase activity, transferring glycosyl groups
SynMINOS11_00667	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynMINOS11_00668	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynMINOS11_00669	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynMINOS11_00670	COG0740	serine-type endopeptidase activity
SynMINOS11_00671	COG0740	serine-type endopeptidase activity
SynMINOS11_00672	COG4956	integral membrane protein (PIN domain superfamily)
SynMINOS11_00673	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynMINOS11_00674	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynMINOS11_00675	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynMINOS11_00678	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynMINOS11_00679	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynMINOS11_00680	COG4948	Mandelate Racemase Muconate Lactonizing
SynMINOS11_00687	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynMINOS11_00688	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynMINOS11_00689	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynMINOS11_00692	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynMINOS11_00693	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynMINOS11_00694	COG0134	indole-3-glycerol-phosphate synthase activity
SynMINOS11_00703	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynMINOS11_00704	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynMINOS11_00706	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynMINOS11_00707	COG1104	cysteine desulfurase activity
SynMINOS11_00719	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMINOS11_00721	COG0706	membrane insertase activity
SynMINOS11_00723	COG0594	ribonuclease P activity
SynMINOS11_00724	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynMINOS11_00728	COG0616	signal peptide processing
SynMINOS11_00729	COG0697	spore germination
SynMINOS11_00730	COG0438	transferase activity, transferring glycosyl groups
SynMINOS11_00732	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynMINOS11_00733	COG0662	Cupin 2, conserved barrel domain protein
SynMINOS11_00733	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynMINOS11_00734	COG3273	potassium ion transport
SynMINOS11_00734	COG0471	metal ion transport
SynMINOS11_00736	COG1842	Phage shock protein A
SynMINOS11_00737	COG3118	belongs to the thioredoxin family
SynMINOS11_00738	COG0436	Aminotransferase
SynMINOS11_00741	COG0739	heme binding
SynMINOS11_00742	COG1136	(ABC) transporter
SynMINOS11_00742	COG0577	efflux transmembrane transporter activity
SynMINOS11_00743	COG1007	ATP synthesis coupled electron transport
SynMINOS11_00744	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynMINOS11_00747	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynMINOS11_00754	COG1845	cytochrome c oxidase, subunit III
SynMINOS11_00755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynMINOS11_00758	COG0109	protoheme IX farnesyltransferase activity
SynMINOS11_00762	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynMINOS11_00765	COG1028	Short-chain dehydrogenase reductase Sdr
SynMINOS11_00768	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynMINOS11_00769	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynMINOS11_00770	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynMINOS11_00776	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynMINOS11_00777	COG3258	Cytochrome c
SynMINOS11_00778	COG0723	plastoquinol--plastocyanin reductase activity
SynMINOS11_00780	COG0805	protein transport
SynMINOS11_00782	COG0194	GDP metabolic process
SynMINOS11_00786	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMINOS11_00789	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynMINOS11_00790	COG0012	GTP binding
SynMINOS11_00794	COG0601	transmembrane transport
SynMINOS11_00797	COG0460	homoserine dehydrogenase
SynMINOS11_00798	COG2166	iron-sulfur cluster assembly
SynMINOS11_00801	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynMINOS11_00802	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynMINOS11_00803	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynMINOS11_00807	COG2010	Cytochrome c
SynMINOS11_00810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynMINOS11_00811	COG1611	Belongs to the LOG family
SynMINOS11_00812	COG3118	belongs to the thioredoxin family
SynMINOS11_00813	COG0516	GMP reductase activity
SynMINOS11_00814	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynMINOS11_00816	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynMINOS11_00817	COG0644	oxidoreductase
SynMINOS11_00819	COG1543	Belongs to the glycosyl hydrolase 57 family
SynMINOS11_00820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynMINOS11_00821	COG0395	ABC-type sugar transport system, permease component
SynMINOS11_00822	COG1480	7TM receptor with intracellular HD hydrolase
SynMINOS11_00823	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynMINOS11_00827	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynMINOS11_00830	COG1254	Belongs to the acylphosphatase family
SynMINOS11_00831	COG1797	cobyrinic acid a,c-diamide synthase activity
SynMINOS11_00832	COG3429	Glucose-6-phosphate dehydrogenase subunit
SynMINOS11_00832	COG3409	Peptidoglycan-binding domain 1 protein
SynMINOS11_00833	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynMINOS11_00837	COG2205	protein histidine kinase activity
SynMINOS11_00842	COG0308	aminopeptidase N
SynMINOS11_00847	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynMINOS11_00850	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
SynMINOS11_00851	COG1640	4-alpha-glucanotransferase
SynMINOS11_00853	COG1187	pseudouridine synthase activity
SynMINOS11_00854	COG5002	protein histidine kinase activity
SynMINOS11_00855	COG0745	RESPONSE REGULATOR receiver
SynMINOS11_00857	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynMINOS11_00858	COG1982	Orn Lys Arg decarboxylase major
SynMINOS11_00859	COG2242	protein methyltransferase activity
SynMINOS11_00859	COG2241	protein methyltransferase activity
SynMINOS11_00860	COG0575	Belongs to the CDS family
SynMINOS11_00863	COG0371	Dehydrogenase
SynMINOS11_00864	COG0542	response to heat
SynMINOS11_00867	COG0019	diaminopimelate decarboxylase activity
SynMINOS11_00869	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynMINOS11_00870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynMINOS11_00871	COG1054	Belongs to the UPF0176 family
SynMINOS11_00873	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynMINOS11_00876	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynMINOS11_00878	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynMINOS11_00879	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynMINOS11_00892	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynMINOS11_00893	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynMINOS11_00896	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynMINOS11_00897	COG1850	ribulose-bisphosphate carboxylase activity
SynMINOS11_00898	COG4451	ribulose bisphosphate carboxylase, small
SynMINOS11_00903	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynMINOS11_00905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynMINOS11_00906	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_00909	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynMINOS11_00910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMINOS11_00913	COG0456	acetyltransferase
SynMINOS11_00915	COG1132	(ABC) transporter
SynMINOS11_00916	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynMINOS11_00917	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynMINOS11_00918	COG0251	oxidation-reduction process
SynMINOS11_00920	COG0488	(ABC) transporter
SynMINOS11_00928	COG2326	polyphosphate kinase activity
SynMINOS11_00931	COG0028	Belongs to the TPP enzyme family
SynMINOS11_00932	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMINOS11_00934	COG2226	methyltransferase
SynMINOS11_00937	COG0528	UMP kinase activity
SynMINOS11_00938	COG0233	cytoplasmic translational termination
SynMINOS11_00941	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynMINOS11_00942	COG0768	penicillin binding
SynMINOS11_00945	COG0588	phosphoglycerate mutase activity
SynMINOS11_00946	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SynMINOS11_00947	COG0681	Belongs to the peptidase S26 family
SynMINOS11_00952	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynMINOS11_00955	COG0442	prolyl-tRNA aminoacylation
SynMINOS11_00958	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynMINOS11_00959	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynMINOS11_00960	COG1324	tolerance protein
SynMINOS11_00965	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynMINOS11_00967	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynMINOS11_00968	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_00973	COG0181	hydroxymethylbilane synthase activity
SynMINOS11_00974	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynMINOS11_00977	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynMINOS11_00983	COG0542	response to heat
SynMINOS11_00986	COG2010	Cytochrome c
SynMINOS11_00988	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynMINOS11_00989	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynMINOS11_00995	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynMINOS11_00996	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SynMINOS11_01008	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SynMINOS11_01009	COG0011	TIGRFAM Protein of
SynMINOS11_01010	COG0339	signal peptide processing
SynMINOS11_01011	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_01012	COG0083	homoserine kinase activity
SynMINOS11_01013	COG0837	glucose binding
SynMINOS11_01014	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynMINOS11_01020	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynMINOS11_01023	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SynMINOS11_01038	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynMINOS11_01041	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMINOS11_01042	COG1429	ligase activity, forming nitrogen-metal bonds
SynMINOS11_01043	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynMINOS11_01045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynMINOS11_01046	COG0149	triose-phosphate isomerase activity
SynMINOS11_01048	COG1132	(ABC) transporter
SynMINOS11_01050	COG1115	amino acid carrier protein
SynMINOS11_01052	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynMINOS11_01060	COG1970	mechanosensitive ion channel activity
SynMINOS11_01065	COG0673	inositol 2-dehydrogenase activity
SynMINOS11_01067	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynMINOS11_01068	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynMINOS11_01070	COG3954	Phosphoribulokinase
SynMINOS11_01071	COG0473	3-isopropylmalate dehydrogenase activity
SynMINOS11_01072	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynMINOS11_01073	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynMINOS11_01076	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynMINOS11_01082	COG2197	response regulator
SynMINOS11_01084	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynMINOS11_01086	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SynMINOS11_01091	COG1201	RNA secondary structure unwinding
SynMINOS11_01092	COG1793	dna ligase
SynMINOS11_01096	COG0598	Magnesium transport protein CorA
SynMINOS11_01126	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynMINOS11_01131	COG0659	secondary active sulfate transmembrane transporter activity
SynMINOS11_01132	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynMINOS11_01132	COG0426	domain, Protein
SynMINOS11_01173	COG0724	RNA recognition motif
SynMINOS11_01202	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SynMINOS11_01203	COG0732	type I restriction modification DNA specificity domain
SynMINOS11_01204	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SynMINOS11_01208	COG2124	cytochrome p450
SynMINOS11_01215	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynMINOS11_01224	COG5002	protein histidine kinase activity
SynMINOS11_01228	COG0367	asparagine synthase
SynMINOS11_01229	COG0540	Belongs to the ATCase OTCase family
SynMINOS11_01235	COG1773	rubredoxin
SynMINOS11_01245	COG0681	Belongs to the peptidase S26 family
SynMINOS11_01246	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynMINOS11_01247	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynMINOS11_01249	COG1376	ErfK ybiS ycfS ynhG family protein
SynMINOS11_01250	COG0297	glycogen (starch) synthase activity
SynMINOS11_01252	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynMINOS11_01253	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynMINOS11_01255	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynMINOS11_01259	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynMINOS11_01260	COG2045	Belongs to the ComB family
SynMINOS11_01263	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynMINOS11_01264	COG0142	geranyltranstransferase activity
SynMINOS11_01278	COG4106	trans-aconitate 2-methyltransferase activity
SynMINOS11_01279	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynMINOS11_01283	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SynMINOS11_01289	COG0415	Belongs to the DNA photolyase family
SynMINOS11_01292	COG0495	leucyl-tRNA aminoacylation
SynMINOS11_01294	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynMINOS11_01295	COG1104	cysteine desulfurase activity
SynMINOS11_01300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynMINOS11_01301	COG0322	excinuclease ABC activity
SynMINOS11_01305	COG2197	response regulator
SynMINOS11_01306	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynMINOS11_01307	COG3046	protein related to deoxyribodipyrimidine photolyase
SynMINOS11_01308	COG1981	membrane
SynMINOS11_01309	COG0587	DNA-directed DNA polymerase activity
SynMINOS11_01312	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynMINOS11_01313	COG1410	methionine synthase
SynMINOS11_01313	COG0646	methionine synthase
SynMINOS11_01318	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SynMINOS11_01320	COG2385	sporulation resulting in formation of a cellular spore
SynMINOS11_01327	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynMINOS11_01328	COG0072	phenylalanine-tRNA ligase activity
SynMINOS11_01329	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynMINOS11_01330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynMINOS11_01331	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
SynMINOS11_01333	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynMINOS11_01340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynMINOS11_01341	COG0739	heme binding
SynMINOS11_01344	COG0450	alkyl hydroperoxide reductase
SynMINOS11_01345	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynMINOS11_01346	COG0047	phosphoribosylformylglycinamidine synthase activity
SynMINOS11_01352	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynMINOS11_01354	COG0129	dihydroxy-acid dehydratase activity
SynMINOS11_01357	COG0363	glucosamine-6-phosphate deaminase activity
SynMINOS11_01358	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynMINOS11_01359	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMINOS11_01360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynMINOS11_01361	COG1494	fructose-1,6-bisphosphatase
SynMINOS11_01362	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynMINOS11_01365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynMINOS11_01367	COG1137	ATPase activity
SynMINOS11_01370	COG1217	gtp-binding protein TYPA
SynMINOS11_01372	COG0644	oxidoreductase
SynMINOS11_01373	COG0751	glycine-tRNA ligase activity
SynMINOS11_01374	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynMINOS11_01375	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynMINOS11_01376	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynMINOS11_01378	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynMINOS11_01379	COG0052	Belongs to the universal ribosomal protein uS2 family
SynMINOS11_01380	COG1216	Glycosyl transferase, family 2
SynMINOS11_01384	COG0811	peptide transport
SynMINOS11_01386	COG1136	(ABC) transporter
SynMINOS11_01390	COG0612	Peptidase, M16
SynMINOS11_01394	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynMINOS11_01395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SynMINOS11_01397	COG0076	glutamate decarboxylase activity
SynMINOS11_01398	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynMINOS11_01400	COG0174	glutamine synthetase
SynMINOS11_01406	COG0515	serine threonine protein kinase
SynMINOS11_01407	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynMINOS11_01408	COG3310	Protein conserved in bacteria
SynMINOS11_01409	COG0628	permease
SynMINOS11_01416	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynMINOS11_01417	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynMINOS11_01418	COG0022	dehydrogenase e1 component
SynMINOS11_01418	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynMINOS11_01421	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynMINOS11_01422	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynMINOS11_01423	COG0792	nuclease activity
SynMINOS11_01426	COG0358	DNA primase activity
SynMINOS11_01429	COG0632	four-way junction helicase activity
SynMINOS11_01430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynMINOS11_01432	COG0587	DNA-directed DNA polymerase activity
SynMINOS11_01433	COG0154	amidase activity
SynMINOS11_01435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynMINOS11_01436	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynMINOS11_01438	COG0505	Belongs to the CarA family
SynMINOS11_01439	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynMINOS11_01441	COG1132	(ABC) transporter
SynMINOS11_01443	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynMINOS11_01447	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynMINOS11_01449	COG2176	DNA-directed DNA polymerase activity
SynMINOS11_01450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynMINOS11_01452	COG0530	calcium, potassium:sodium antiporter activity
SynMINOS11_01453	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynMINOS11_01454	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynMINOS11_01455	COG2271	Major facilitator Superfamily
SynMINOS11_01456	COG0166	Belongs to the GPI family
SynMINOS11_01461	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynMINOS11_01462	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynMINOS11_01463	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynMINOS11_01463	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynMINOS11_01464	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynMINOS11_01465	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynMINOS11_01466	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynMINOS11_01468	COG0484	heat shock protein binding
SynMINOS11_01469	COG0443	Heat shock 70 kDa protein
SynMINOS11_01470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynMINOS11_01471	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynMINOS11_01472	COG0573	inorganic phosphate transmembrane transporter activity
SynMINOS11_01473	COG0581	inorganic phosphate transmembrane transporter activity
SynMINOS11_01474	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynMINOS11_01475	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynMINOS11_01477	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynMINOS11_01478	COG0483	inositol monophosphate 1-phosphatase activity
SynMINOS11_01479	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynMINOS11_01481	COG0326	Molecular chaperone. Has ATPase activity
SynMINOS11_01483	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynMINOS11_01484	COG1653	transport
SynMINOS11_01487	COG3842	ATPase activity
SynMINOS11_01490	COG0366	Alpha amylase catalytic
SynMINOS11_01491	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynMINOS11_01492	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynMINOS11_01493	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynMINOS11_01494	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynMINOS11_01500	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynMINOS11_01501	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynMINOS11_01509	COG0469	pyruvate kinase activity
SynMINOS11_01510	COG1136	(ABC) transporter
SynMINOS11_01510	COG0577	efflux transmembrane transporter activity
SynMINOS11_01512	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMINOS11_01514	COG0740	serine-type endopeptidase activity
SynMINOS11_01519	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynMINOS11_01527	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynMINOS11_01528	COG1175	transmembrane transport
SynMINOS11_01529	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynMINOS11_01530	COG2226	methyltransferase
SynMINOS11_01533	COG1942	4-Oxalocrotonate Tautomerase
SynMINOS11_01544	COG2197	response regulator
SynMINOS11_01545	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SynMINOS11_01549	COG0475	glutathione-regulated potassium exporter activity
SynMINOS11_01557	COG0180	Tryptophanyl-tRNA synthetase
SynMINOS11_01559	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynMINOS11_01560	COG1122	ATPase activity
SynMINOS11_01565	COG1836	PFAM Integral membrane protein DUF92
SynMINOS11_01566	COG1191	sigma factor activity
SynMINOS11_01567	COG3639	organic phosphonate transmembrane transporter activity
SynMINOS11_01568	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynMINOS11_01569	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynMINOS11_01570	COG0436	Aminotransferase
SynMINOS11_01572	COG1573	uracil-dna glycosylase
SynMINOS11_01574	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynMINOS11_01575	COG0793	Belongs to the peptidase S41A family
SynMINOS11_01577	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynMINOS11_01586	COG0861	Integral membrane protein TerC family
SynMINOS11_01588	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynMINOS11_01590	COG0312	modulator of DNA gyrase
SynMINOS11_01591	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynMINOS11_01594	COG0163	prenyltransferase activity
SynMINOS11_01595	COG0557	exoribonuclease II activity
SynMINOS11_01597	COG2119	membrane
SynMINOS11_01601	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynMINOS11_01601	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynMINOS11_01602	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynMINOS11_01604	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynMINOS11_01605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMINOS11_01606	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SynMINOS11_01607	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SynMINOS11_01609	COG0191	fructose-bisphosphate aldolase activity
SynMINOS11_01613	COG0435	Glutathione S-transferase
SynMINOS11_01620	COG0432	Pfam Uncharacterised protein family UPF0047
SynMINOS11_01623	COG3179	chitinase
SynMINOS11_01628	COG0477	Major facilitator Superfamily
SynMINOS11_01630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMINOS11_01642	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynMINOS11_01671	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynMINOS11_01672	COG1233	COG1233 Phytoene dehydrogenase and related
SynMINOS11_01673	COG2095	MarC family integral membrane protein
SynMINOS11_01674	COG0076	glutamate decarboxylase activity
SynMINOS11_01678	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynMINOS11_01679	COG0271	Belongs to the BolA IbaG family
SynMINOS11_01682	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynMINOS11_01684	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynMINOS11_01685	COG1074	ATP-dependent DNA helicase activity
SynMINOS11_01686	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynMINOS11_01689	COG0513	Belongs to the DEAD box helicase family
SynMINOS11_01695	COG1316	TRANSCRIPTIONal
SynMINOS11_01696	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynMINOS11_01697	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynMINOS11_01698	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynMINOS11_01701	COG1741	Belongs to the pirin family
SynMINOS11_01702	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynMINOS11_01703	COG0569	domain protein
SynMINOS11_01707	COG0704	Plays a role in the regulation of phosphate uptake
SynMINOS11_01710	COG0095	Lipoate-protein ligase
SynMINOS11_01711	COG0517	IMP dehydrogenase activity
SynMINOS11_01711	COG1994	Peptidase M50
SynMINOS11_01712	COG0135	phosphoribosylanthranilate isomerase activity
SynMINOS11_01714	COG0302	gtp cyclohydrolase
SynMINOS11_01715	COG0300	oxidoreductase activity
SynMINOS11_01717	COG5322	oxidoreductase activity
SynMINOS11_01718	COG3396	Phenylacetate-CoA oxygenase
SynMINOS11_01720	COG0539	negative regulation of cytoplasmic translation
SynMINOS11_01722	COG1496	oxidoreductase activity
SynMINOS11_01729	COG2010	Cytochrome c
SynMINOS11_01731	COG0159	tryptophan synthase activity
SynMINOS11_01741	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_01744	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynMINOS11_01745	COG1121	(ABC) transporter
SynMINOS11_01746	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynMINOS11_01747	COG0701	Predicted permease
SynMINOS11_01750	COG0140	phosphoribosyl-ATP diphosphatase activity
SynMINOS11_01750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynMINOS11_01751	COG0720	synthase
SynMINOS11_01760	COG0523	cobalamin synthesis protein
SynMINOS11_01763	COG1840	ABC-type Fe3 transport system, periplasmic component
SynMINOS11_01765	COG3842	ATPase activity
SynMINOS11_01766	COG0735	belongs to the Fur family
SynMINOS11_01772	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynMINOS11_01778	COG0277	FAD linked oxidase domain protein
SynMINOS11_01779	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynMINOS11_01780	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SynMINOS11_01783	COG0405	Gamma-glutamyltransferase
SynMINOS11_01790	COG1666	GTP binding
SynMINOS11_01793	COG0857	belongs to the CobB CobQ family
SynMINOS11_01794	COG0300	oxidoreductase activity
SynMINOS11_01794	COG3000	fatty acid hydroxylase
SynMINOS11_01795	COG0024	Methionine aminopeptidase
SynMINOS11_01797	COG0335	large ribosomal subunit rRNA binding
SynMINOS11_01801	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynMINOS11_01804	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynMINOS11_01804	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynMINOS11_01805	COG0215	cysteine-tRNA ligase activity
SynMINOS11_01808	COG0733	neurotransmitter:sodium symporter activity
SynMINOS11_01809	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynMINOS11_01817	COG0492	ferredoxin-NADP+ reductase activity
SynMINOS11_01818	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynMINOS11_01819	COG1187	pseudouridine synthase activity
SynMINOS11_01825	COG0440	acetolactate synthase activity
SynMINOS11_01826	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynMINOS11_01836	COG0424	maF-like protein
SynMINOS11_01838	COG1492	cobalamin metabolic process
SynMINOS11_01841	COG0482	sulfurtransferase activity
SynMINOS11_01842	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynMINOS11_01842	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynMINOS11_01843	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_01844	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynMINOS11_01845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynMINOS11_01847	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynMINOS11_01848	COG0228	four-way junction DNA binding
SynMINOS11_01849	COG1702	phosphate starvation-inducible protein PhoH
SynMINOS11_01857	COG3527	Alpha-acetolactate decarboxylase
SynMINOS11_01858	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynMINOS11_01861	COG0336	Belongs to the RNA methyltransferase TrmD family
SynMINOS11_01862	COG0330	HflC and HflK could
SynMINOS11_01864	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SynMINOS11_01867	COG1691	(AIR) carboxylase
SynMINOS11_01871	COG0352	thiamine-phosphate diphosphorylase activity
SynMINOS11_01873	COG0196	riboflavin kinase activity
SynMINOS11_01875	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynMINOS11_01876	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynMINOS11_01877	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynMINOS11_01878	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynMINOS11_01879	COG0745	RESPONSE REGULATOR receiver
SynMINOS11_01886	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynMINOS11_01886	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynMINOS11_01889	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMINOS11_01891	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynMINOS11_01892	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynMINOS11_01895	COG3239	Fatty acid desaturase
SynMINOS11_01898	COG1028	Short-chain dehydrogenase reductase Sdr
SynMINOS11_01924	COG2105	PFAM AIG2 family protein
SynMINOS11_01931	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynMINOS11_01932	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMINOS11_01935	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SynMINOS11_01936	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynMINOS11_01937	COG0531	amino acid
SynMINOS11_01940	COG1022	Amp-dependent synthetase and ligase
SynMINOS11_01941	COG0321	lipoyl(octanoyl) transferase activity
SynMINOS11_01942	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynMINOS11_01943	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynMINOS11_01946	COG0438	transferase activity, transferring glycosyl groups
SynMINOS11_01947	COG0284	orotidine-5'-phosphate decarboxylase activity
SynMINOS11_01949	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynMINOS11_01954	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynMINOS11_01956	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_01959	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynMINOS11_01960	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynMINOS11_01961	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynMINOS11_01962	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynMINOS11_01963	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynMINOS11_01965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynMINOS11_01968	COG0151	Belongs to the GarS family
SynMINOS11_01969	COG5002	protein histidine kinase activity
SynMINOS11_01970	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynMINOS11_01971	COG4251	negative regulation of phosphorylation
SynMINOS11_01973	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynMINOS11_01974	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynMINOS11_01977	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynMINOS11_01979	COG0217	transcriptional regulatory protein
SynMINOS11_01981	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynMINOS11_01983	COG0363	glucosamine-6-phosphate deaminase activity
SynMINOS11_01984	COG2385	sporulation resulting in formation of a cellular spore
SynMINOS11_01984	COG2247	cell wall binding repeat
SynMINOS11_01985	COG1234	tRNA 3'-trailer cleavage
SynMINOS11_01986	COG2010	Cytochrome c
SynMINOS11_01989	COG2264	protein methyltransferase activity
SynMINOS11_01990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynMINOS11_01994	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynMINOS11_02000	COG1077	Cell shape determining protein MreB Mrl
SynMINOS11_02003	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynMINOS11_02006	COG0459	protein refolding
SynMINOS11_02007	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynMINOS11_02008	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynMINOS11_02009	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynMINOS11_02012	COG0387	Pfam Sodium calcium exchanger
SynMINOS11_02013	COG0006	proline dipeptidase activity
SynMINOS11_02014	COG1253	flavin adenine dinucleotide binding
SynMINOS11_02015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynMINOS11_02016	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynMINOS11_02017	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynMINOS11_02017	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynMINOS11_02020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynMINOS11_02022	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynMINOS11_02024	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynMINOS11_02025	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynMINOS11_02026	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynMINOS11_02027	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynMINOS11_02028	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynMINOS11_02029	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynMINOS11_02030	COG0356	it plays a direct role in the translocation of protons across the membrane
SynMINOS11_02032	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynMINOS11_02033	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMINOS11_02038	COG0772	Belongs to the SEDS family
SynMINOS11_02041	COG1333	cytochrome c biogenesis protein
SynMINOS11_02042	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynMINOS11_02043	COG0347	Belongs to the P(II) protein family
SynMINOS11_02046	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynMINOS11_02068	COG4581	dead DEAH box helicase
SynMINOS11_02069	COG0156	8-amino-7-oxononanoate synthase activity
SynMINOS11_02070	COG1381	Involved in DNA repair and RecF pathway recombination
SynMINOS11_02071	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynMINOS11_02071	COG4106	trans-aconitate 2-methyltransferase activity
SynMINOS11_02072	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynMINOS11_02081	COG2010	Cytochrome c
SynMINOS11_02081	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynMINOS11_02084	COG0114	fumarate hydratase activity
SynMINOS11_02085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynMINOS11_02091	COG0484	heat shock protein binding
SynMINOS11_02092	COG0357	Ribosomal RNA small subunit methyltransferase G
SynMINOS11_02099	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SynMINOS11_02100	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynMINOS11_02102	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynMINOS11_02103	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynMINOS11_02104	COG0085	RNA polymerase activity
SynMINOS11_02106	COG0084	hydrolase, TatD family'
SynMINOS11_02107	COG0268	Binds directly to 16S ribosomal RNA
SynMINOS11_02108	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynMINOS11_02110	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynMINOS11_02111	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMINOS11_02114	COG0779	Required for maturation of 30S ribosomal subunits
SynMINOS11_02115	COG0195	Participates in both transcription termination and antitermination
SynMINOS11_02117	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynMINOS11_02149	COG1012	belongs to the aldehyde dehydrogenase family
SynMINOS11_02164	COG0463	Glycosyl transferase, family 2
SynMINOS11_02165	COG0366	Alpha amylase catalytic
SynMINOS11_02166	COG3769	mannosylglycerate metabolic process
SynMINOS11_02168	COG0235	Class ii aldolase
SynMINOS11_02170	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynMINOS11_02173	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynMINOS11_02174	COG0719	Fe-S assembly protein
SynMINOS11_02175	COG0396	ATPase activity
SynMINOS11_02176	COG0719	Fe-S assembly protein
SynMINOS11_02177	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynMINOS11_02178	COG1830	Aldolase
SynMINOS11_02182	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMINOS11_02186	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynMINOS11_02188	COG3264	Mechanosensitive ion channel
SynMINOS11_02188	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SynMINOS11_02194	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynMINOS11_02230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynMINOS11_02231	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynMINOS11_02231	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynMINOS11_02232	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynMINOS11_02234	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynMINOS11_02243	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SynMINOS11_02247	COG0408	coproporphyrinogen oxidase activity
SynMINOS11_02248	COG0489	protein tyrosine kinase activity
SynMINOS11_02249	COG0772	Belongs to the SEDS family
SynMINOS11_02252	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynMINOS11_02253	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynMINOS11_02254	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynMINOS11_02257	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynMINOS11_02259	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynMINOS11_02260	COG1606	tRNA processing
SynMINOS11_02264	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynMINOS11_02267	COG1132	(ABC) transporter
SynMINOS11_02271	COG3001	Fructosamine kinase
SynMINOS11_02273	COG0287	Prephenate dehydrogenase
SynMINOS11_02277	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynMINOS11_02280	COG3854	ATPases associated with a variety of cellular activities
SynMINOS11_02283	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynMINOS11_02284	COG0088	Forms part of the polypeptide exit tunnel
SynMINOS11_02285	COG0089	rRNA binding
SynMINOS11_02286	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynMINOS11_02287	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynMINOS11_02288	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynMINOS11_02289	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynMINOS11_02290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynMINOS11_02291	COG0255	Belongs to the universal ribosomal protein uL29 family
SynMINOS11_02292	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynMINOS11_02293	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynMINOS11_02294	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynMINOS11_02295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynMINOS11_02296	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynMINOS11_02297	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynMINOS11_02298	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynMINOS11_02299	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynMINOS11_02300	COG0200	Binds to the 23S rRNA
SynMINOS11_02301	COG0201	protein transport
SynMINOS11_02302	COG0563	adenylate kinase activity
SynMINOS11_02303	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynMINOS11_02304	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynMINOS11_02305	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynMINOS11_02306	COG0202	RNA polymerase activity
SynMINOS11_02307	COG0203	ribosomal protein L17
SynMINOS11_02308	COG0101	tRNA pseudouridine synthase activity
SynMINOS11_02310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynMINOS11_02311	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynMINOS11_02312	COG0254	rRNA binding
SynMINOS11_02313	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynMINOS11_02315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynMINOS11_02319	COG0791	NLP P60 protein
SynMINOS11_02320	COG0463	Glycosyl transferase, family 2
SynMINOS11_02326	COG2885	chlorophyll binding
SynMINOS11_02327	COG2885	chlorophyll binding
SynMINOS11_02332	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynMINOS11_02333	COG0659	secondary active sulfate transmembrane transporter activity
SynMINOS11_02334	COG0067	glutamate synthase
SynMINOS11_02334	COG0069	glutamate synthase activity
SynMINOS11_02334	COG0070	glutamate synthase
SynMINOS11_02337	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynMINOS11_02338	COG0049	tRNA binding
SynMINOS11_02339	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynMINOS11_02340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynMINOS11_02341	COG0051	transcription antitermination factor activity, RNA binding
SynMINOS11_02344	COG2226	methyltransferase
SynMINOS11_02345	COG0077	Prephenate dehydratase
SynMINOS11_02346	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynMINOS11_02347	COG1530	ribonuclease E activity
SynMINOS11_02348	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynMINOS11_02349	COG0436	Aminotransferase
SynMINOS11_02350	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynMINOS11_02357	COG1121	(ABC) transporter
SynMINOS11_02358	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynMINOS11_02359	COG3386	PFAM SMP-30 Gluconolaconase
SynMINOS11_02360	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynMINOS11_02363	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynMINOS11_02364	COG0529	Catalyzes the synthesis of activated sulfate
SynMINOS11_02364	COG2046	Belongs to the sulfate adenylyltransferase family
SynMINOS11_02367	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynMINOS11_02368	COG3536	Protein conserved in bacteria
SynMINOS11_02375	COG0540	Belongs to the ATCase OTCase family
SynMINOS11_02376	COG2094	Belongs to the DNA glycosylase MPG family
SynMINOS11_02379	COG1402	creatininase
SynMINOS11_02380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynMINOS11_02385	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynMINOS11_02389	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynMINOS11_02392	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynMINOS11_02394	COG0741	lytic transglycosylase activity
SynMINOS11_02397	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynMINOS11_02398	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynMINOS11_02402	COG0126	phosphoglycerate kinase activity
SynMINOS11_02403	COG0589	response to stress
SynMINOS11_02404	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SynMINOS11_02405	COG0564	pseudouridine synthase activity
SynMINOS11_02407	COG4172	Belongs to the ABC transporter superfamily
SynMINOS11_02408	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynMINOS11_02411	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynMINOS11_02413	COG0157	Belongs to the NadC ModD family
SynMINOS11_02414	COG0018	arginyl-trna synthetase
SynMINOS11_02415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynMINOS11_02421	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynMINOS11_02422	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynMINOS11_02424	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynMINOS11_02425	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynMINOS11_02426	COG0189	ligase activity
SynMINOS11_02428	COG1575	Belongs to the MenA family. Type 1 subfamily
SynMINOS11_02431	COG0824	Thioesterase
SynMINOS11_02432	COG0649	NAD binding
SynMINOS11_02433	COG0275	rRNA processing
SynMINOS11_02434	COG1104	cysteine desulfurase activity
SynMINOS11_02436	COG0745	RESPONSE REGULATOR receiver
SynMINOS11_02437	COG0564	pseudouridine synthase activity
SynMINOS11_02439	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynMINOS11_02440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SynMINOS11_02441	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynMINOS11_02442	COG0628	permease
SynMINOS11_02443	COG0529	Catalyzes the synthesis of activated sulfate
SynMINOS11_02444	COG0023	Translation Initiation Factor
SynMINOS11_02447	COG0133	tryptophan synthase activity
SynMINOS11_02448	COG1420	regulation of RNA biosynthetic process
SynMINOS11_02451	COG2062	phosphohistidine phosphatase, SixA
SynMINOS11_02452	COG0372	Belongs to the citrate synthase family
SynMINOS11_02453	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynMINOS11_02454	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynMINOS11_02455	COG0839	Belongs to the complex I subunit 6 family
SynMINOS11_02457	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynMINOS11_02465	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynMINOS11_02466	COG0131	Imidazoleglycerol-phosphate dehydratase
SynMINOS11_02468	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynMINOS11_02469	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynMINOS11_02473	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynMINOS11_02474	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynMINOS11_02478	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynMINOS11_02481	COG0625	glutathione transferase activity
SynMINOS11_02483	COG1253	flavin adenine dinucleotide binding
SynMINOS11_02484	COG0673	inositol 2-dehydrogenase activity
SynMINOS11_02488	COG0343	queuine tRNA-ribosyltransferase activity
SynMINOS11_02490	COG2205	protein histidine kinase activity
SynMINOS11_02493	COG0138	bifunctional purine biosynthesis protein purh
SynMINOS11_02496	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynMINOS11_02497	COG0004	ammonium transporteR
SynMINOS11_02501	COG1489	DNA binding
SynMINOS11_02502	COG0728	peptidoglycan biosynthetic process
SynMINOS11_02507	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynMINOS11_02508	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynMINOS11_02509	COG1058	Belongs to the CinA family
SynMINOS11_02509	COG1546	Belongs to the CinA family
SynMINOS11_02510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynMINOS11_02511	COG0066	3-isopropylmalate dehydratase activity
SynMINOS11_02518	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynMINOS11_02522	COG4372	Transposase
SynMINOS11_02523	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynMINOS11_02525	COG0717	Belongs to the dCTP deaminase family
SynMINOS11_02527	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynMINOS11_02531	COG0167	dihydroorotate dehydrogenase activity
SynMINOS11_02532	COG0328	RNA-DNA hybrid ribonuclease activity
SynMINOS11_02533	COG0222	ribosome binding
SynMINOS11_02534	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynMINOS11_02536	COG0081	regulation of translation
SynMINOS11_02537	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynMINOS11_02538	COG0250	Participates in transcription elongation, termination and antitermination
SynMINOS11_02539	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynMINOS11_02540	COG0542	response to heat
SynMINOS11_02541	COG0346	lactoylglutathione lyase activity
SynMINOS11_02542	COG0148	phosphopyruvate hydratase activity
SynMINOS11_02543	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynMINOS11_02556	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMINOS11_02557	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynMINOS11_02558	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynMINOS11_02559	COG0237	dephospho-CoA kinase activity
SynMINOS11_02560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynMINOS11_02562	COG2022	thiamine diphosphate biosynthetic process
SynMINOS11_02562	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynMINOS11_02563	COG0105	UTP biosynthetic process
SynMINOS11_02564	COG1166	arginine decarboxylase activity
SynMINOS11_02572	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynMINOS11_02573	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynMINOS11_02576	COG0071	Belongs to the small heat shock protein (HSP20) family
SynMINOS11_02578	COG0426	domain, Protein
SynMINOS11_02578	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynMINOS11_02579	COG0426	domain, Protein
SynMINOS11_02579	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynMINOS11_02582	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynMINOS11_02582	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynMINOS11_02583	COG0509	glycine decarboxylation via glycine cleavage system
SynMINOS11_02584	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynMINOS11_02588	COG0359	binds to the 23S rRNA
SynMINOS11_02589	COG0305	Participates in initiation and elongation during chromosome replication
SynMINOS11_02589	COG1372	Participates in initiation and elongation during chromosome replication
SynMINOS11_02589	COG1372	Participates in initiation and elongation during chromosome replication
SynMINOS11_02589	COG0305	Participates in initiation and elongation during chromosome replication
SynMINOS11_02593	COG0445	tRNA wobble uridine modification
SynMINOS11_02603	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynMINOS11_02605	COG0398	Pfam SNARE associated Golgi protein
SynMINOS11_02606	COG0668	transmembrane transport
SynMINOS11_02607	COG0525	valine-tRNA ligase activity
SynMINOS11_02617	COG3956	TIGRFAM MazG family protein
SynMINOS11_02618	COG0288	reversible hydration of carbon dioxide
SynMINOS11_02619	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynMINOS11_02620	COG0010	Belongs to the arginase family
SynMINOS11_02622	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynMINOS11_02623	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynMINOS11_02624	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_02625	COG0783	Belongs to the Dps family
SynMINOS11_02627	COG0504	CTP synthase activity
SynMINOS11_02628	COG0602	queuosine metabolic process
SynMINOS11_02629	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynMINOS11_02639	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynMINOS11_02641	COG0830	nickel cation binding
SynMINOS11_02642	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynMINOS11_02643	COG0829	nickel cation binding
SynMINOS11_02645	COG0831	urea catabolic process
SynMINOS11_02646	COG0832	Belongs to the urease beta subunit family
SynMINOS11_02647	COG0804	urea catabolic process
SynMINOS11_02649	COG2308	Evidence 4 Homologs of previously reported genes of
SynMINOS11_02656	COG4638	Rieske (2fe-2S)
SynMINOS11_02657	COG1116	anion transmembrane transporter activity
SynMINOS11_02658	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynMINOS11_02661	COG0375	protein maturation
SynMINOS11_02662	COG0010	Belongs to the arginase family
SynMINOS11_02663	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynMINOS11_02665	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynMINOS11_02667	COG2116	formate transmembrane transporter activity
SynMINOS11_02669	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynMINOS11_02671	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynMINOS11_02676	COG0243	molybdopterin cofactor binding
SynMINOS11_02677	COG2223	nitrite transmembrane transporter activity
SynMINOS11_02678	COG0746	molybdenum cofactor guanylyltransferase activity
SynMINOS11_02679	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynMINOS11_02681	COG1643	Atp-dependent helicase
SynMINOS11_02683	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynMINOS11_02685	COG0314	molybdopterin synthase activity
SynMINOS11_02686	COG0303	'Molybdopterin
SynMINOS11_02687	COG0315	cyclic pyranopterin monophosphate synthase activity
SynMINOS11_02688	COG0590	tRNA wobble adenosine to inosine editing
SynMINOS11_02690	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynMINOS11_02691	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynMINOS11_02692	COG0170	dolichyl monophosphate biosynthetic process
SynMINOS11_02694	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynMINOS11_02695	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynMINOS11_02698	COG0788	formyltetrahydrofolate deformylase activity
SynMINOS11_02702	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynMINOS11_02702	COG2022	thiamine diphosphate biosynthetic process
SynMINOS11_02703	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynMINOS11_02704	COG0443	Heat shock 70 kDa protein
SynMINOS11_02705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynMINOS11_02707	COG0360	Binds together with S18 to 16S ribosomal RNA
SynMINOS11_02709	COG0137	argininosuccinate synthase activity
SynMINOS11_02712	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynMINOS11_02715	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynMINOS11_02716	COG0438	transferase activity, transferring glycosyl groups
SynMINOS11_02718	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynMINOS11_02719	COG0497	DNA recombination
SynMINOS11_02720	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynMINOS11_02722	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SynMINOS11_50004	COG0025	NhaP-type Na H and K H