locus-tag	class	description
LY254_00025	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LY254_00030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LY254_00040	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
LY254_00070	COG4451	ribulose bisphosphate carboxylase, small
LY254_00075	COG1850	ribulose-bisphosphate carboxylase activity
LY254_00080	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
LY254_00095	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LY254_00100	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
LY254_00120	COG0531	amino acid
LY254_00125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LY254_00130	COG0659	secondary active sulfate transmembrane transporter activity
LY254_00155	COG0004	ammonium transporteR
LY254_00165	COG1959	2 iron, 2 sulfur cluster binding
LY254_00170	COG0471	metal ion transport
LY254_00170	COG3273	potassium ion transport
LY254_00180	COG1253	flavin adenine dinucleotide binding
LY254_00185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LY254_00190	COG0569	domain protein
LY254_00195	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LY254_00200	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LY254_00205	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
LY254_00245	COG0730	response to heat
LY254_00250	COG0095	Lipoate-protein ligase
LY254_00255	COG0517	IMP dehydrogenase activity
LY254_00255	COG1994	Peptidase M50
LY254_00260	COG0135	phosphoribosylanthranilate isomerase activity
LY254_00270	COG0302	gtp cyclohydrolase
LY254_00275	COG4221	oxidoreductase activity
LY254_00280	COG0825	malonyl-CoA metabolic process
LY254_00285	COG5322	oxidoreductase activity
LY254_00290	COG3396	Phenylacetate-CoA oxygenase
LY254_00300	COG0539	negative regulation of cytoplasmic translation
LY254_00310	COG1496	oxidoreductase activity
LY254_00315	COG0415	Belongs to the DNA photolyase family
LY254_00325	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LY254_00350	COG0028	Belongs to the TPP enzyme family
LY254_00355	COG0739	heme binding
LY254_00360	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LY254_00380	COG0528	UMP kinase activity
LY254_00385	COG0233	cytoplasmic translational termination
LY254_00400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LY254_00405	COG0768	penicillin binding
LY254_00425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LY254_00430	COG0681	Belongs to the peptidase S26 family
LY254_00455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LY254_00465	COG0442	prolyl-tRNA aminoacylation
LY254_00480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LY254_00490	COG2099	Precorrin-6x reductase
LY254_00495	COG0629	single-stranded DNA binding
LY254_00510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LY254_00520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LY254_00525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LY254_00530	COG1215	transferase activity, transferring glycosyl groups
LY254_00535	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LY254_00550	COG0181	hydroxymethylbilane synthase activity
LY254_00565	COG1611	Belongs to the LOG family
LY254_00570	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LY254_00610	COG2154	pterin-4-alpha-carbinolamine dehydratase
LY254_00620	COG0542	response to heat
LY254_00640	COG2010	Cytochrome c
LY254_00650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LY254_00655	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LY254_00695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LY254_00730	COG0339	signal peptide processing
LY254_00735	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LY254_00740	COG0083	homoserine kinase activity
LY254_00745	COG0837	glucose binding
LY254_00750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LY254_00765	COG0180	Tryptophanyl-tRNA synthetase
LY254_00805	COG1799	cell septum assembly
LY254_00810	COG0428	transporter
LY254_00825	COG0681	Belongs to the peptidase S26 family
LY254_00830	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LY254_00835	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LY254_00840	COG1376	ErfK ybiS ycfS ynhG family protein
LY254_00845	COG0297	glycogen (starch) synthase activity
LY254_00855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LY254_00865	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LY254_00870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LY254_00870	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LY254_00875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LY254_00890	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LY254_00895	COG2045	Belongs to the ComB family
LY254_00910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LY254_00915	COG0142	geranyltranstransferase activity
LY254_00920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LY254_00925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LY254_00935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LY254_00970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LY254_00980	COG1132	(ABC) transporter
LY254_00990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LY254_00995	COG0505	Belongs to the CarA family
LY254_01005	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LY254_01010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LY254_01020	COG0154	amidase activity
LY254_01025	COG0587	DNA-directed DNA polymerase activity
LY254_01035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LY254_01040	COG0632	four-way junction helicase activity
LY254_01055	COG0358	DNA primase activity
LY254_01070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LY254_01100	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LY254_01105	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LY254_01115	COG0022	dehydrogenase e1 component
LY254_01120	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LY254_01125	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LY254_01140	COG0628	permease
LY254_01145	COG3310	Protein conserved in bacteria
LY254_01150	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LY254_01155	COG0515	serine threonine protein kinase
LY254_01180	COG2226	methyltransferase
LY254_01190	COG0174	glutamine synthetase
LY254_01200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LY254_01205	COG0590	tRNA wobble adenosine to inosine editing
LY254_01220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LY254_01240	COG0612	Peptidase, M16
LY254_01250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LY254_01260	COG1136	(ABC) transporter
LY254_01270	COG1216	Glycosyl transferase, family 2
LY254_01275	COG0052	Belongs to the universal ribosomal protein uS2 family
LY254_01280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LY254_01290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LY254_01295	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LY254_01300	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LY254_01305	COG0751	glycine-tRNA ligase activity
LY254_01315	COG0644	oxidoreductase
LY254_01325	COG0826	peptidase U32
LY254_01330	COG1217	gtp-binding protein TYPA
LY254_01345	COG1137	ATPase activity
LY254_01360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LY254_01365	COG1494	fructose-1,6-bisphosphatase
LY254_01370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LY254_01375	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LY254_01380	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LY254_01385	COG0363	glucosamine-6-phosphate deaminase activity
LY254_01400	COG0129	dihydroxy-acid dehydratase activity
LY254_01410	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LY254_01435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LY254_01440	COG0047	phosphoribosylformylglycinamidine synthase activity
LY254_01445	COG1619	proteins homologs of microcin C7 resistance protein MccF
LY254_01450	COG0450	alkyl hydroperoxide reductase
LY254_01460	COG0745	RESPONSE REGULATOR receiver
LY254_01495	COG0798	PFAM Bile acid sodium symporter
LY254_01555	COG2132	Multicopper oxidase
LY254_01570	COG5002	protein histidine kinase activity
LY254_01610	COG0582	viral genome integration into host DNA
LY254_01625	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LY254_01660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LY254_01670	COG0557	exoribonuclease II activity
LY254_01675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LY254_01680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LY254_01685	COG0072	phenylalanine-tRNA ligase activity
LY254_01690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LY254_01715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LY254_01730	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LY254_01750	COG1410	methionine synthase
LY254_01750	COG0646	methionine synthase
LY254_01755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LY254_01775	COG1981	membrane
LY254_01780	COG3046	protein related to deoxyribodipyrimidine photolyase
LY254_01790	COG0322	excinuclease ABC activity
LY254_01795	COG0426	domain, Protein
LY254_01795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LY254_01800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LY254_01825	COG1104	cysteine desulfurase activity
LY254_01830	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LY254_01840	COG0495	leucyl-tRNA aminoacylation
LY254_01845	COG0166	Belongs to the GPI family
LY254_01870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LY254_01875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LY254_01880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LY254_01880	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LY254_01885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LY254_01890	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LY254_01895	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LY254_01905	COG0484	heat shock protein binding
LY254_01910	COG0443	Heat shock 70 kDa protein
LY254_01915	COG0573	inorganic phosphate transmembrane transporter activity
LY254_01920	COG0581	inorganic phosphate transmembrane transporter activity
LY254_01925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LY254_01935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LY254_01940	COG0483	inositol monophosphate 1-phosphatase activity
LY254_01945	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LY254_01975	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LY254_01980	COG1653	transport
LY254_02015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LY254_02020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LY254_02025	COG0668	transmembrane transport
LY254_02030	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LY254_02035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LY254_02045	COG2308	Evidence 4 Homologs of previously reported genes of
LY254_02095	COG1119	ATPase activity
LY254_02135	COG1051	belongs to the nudix hydrolase family
LY254_02200	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LY254_02200	COG0284	orotidine-5'-phosphate decarboxylase activity
LY254_02210	COG1131	(ABC) transporter
LY254_02245	COG2226	methyltransferase
LY254_02295	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LY254_02300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LY254_02325	COG0469	pyruvate kinase activity
LY254_02330	COG1136	(ABC) transporter
LY254_02330	COG0577	efflux transmembrane transporter activity
LY254_02340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LY254_02350	COG0740	serine-type endopeptidase activity
LY254_02365	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LY254_02380	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LY254_02430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LY254_02435	COG1175	transmembrane transport
LY254_02440	COG0514	ATP-dependent DNA helicase (RecQ)
LY254_02445	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LY254_02475	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LY254_02480	COG3588	fructose-bisphosphate aldolase
LY254_02490	COG1793	dna ligase
LY254_02495	COG1201	RNA secondary structure unwinding
LY254_02545	COG0625	glutathione transferase activity
LY254_02560	COG0516	GMP reductase activity
LY254_02560	COG0517	IMP dehydrogenase activity
LY254_02565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LY254_02585	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LY254_02595	COG2197	response regulator
LY254_02600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LY254_02605	COG0114	fumarate hydratase activity
LY254_02610	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LY254_02625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LY254_02640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LY254_02645	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LY254_02650	COG0473	3-isopropylmalate dehydrogenase activity
LY254_02655	COG3954	Phosphoribulokinase
LY254_02665	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LY254_02670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LY254_02680	COG0673	inositol 2-dehydrogenase activity
LY254_02685	COG0191	fructose-bisphosphate aldolase activity
LY254_02695	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LY254_02700	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LY254_02710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LY254_02715	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LY254_02725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LY254_02730	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LY254_02730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LY254_02745	COG2119	membrane
LY254_02755	COG0557	exoribonuclease II activity
LY254_02760	COG0163	prenyltransferase activity
LY254_02775	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
LY254_02780	COG0312	modulator of DNA gyrase
LY254_02790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LY254_02800	COG0513	Belongs to the DEAD box helicase family
LY254_02815	COG0861	Integral membrane protein TerC family
LY254_02830	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LY254_02840	COG0793	Belongs to the peptidase S41A family
LY254_02845	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LY254_02850	COG1573	uracil-dna glycosylase
LY254_02860	COG0436	Aminotransferase
LY254_02865	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LY254_02875	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LY254_02880	COG3639	organic phosphonate transmembrane transporter activity
LY254_02890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LY254_02895	COG1836	PFAM Integral membrane protein DUF92
LY254_02915	COG1122	ATPase activity
LY254_02920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LY254_02940	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LY254_02945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LY254_03010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LY254_03020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LY254_03025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LY254_03035	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LY254_03040	COG1429	ligase activity, forming nitrogen-metal bonds
LY254_03055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LY254_03060	COG1132	(ABC) transporter
LY254_03065	COG2274	protein secretion by the type I secretion system
LY254_03075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LY254_03080	COG0149	triose-phosphate isomerase activity
LY254_03090	COG3706	GGDEF domain
LY254_03100	COG5001	Diguanylate cyclase
LY254_03100	COG3300	MHYT domain
LY254_03105	COG1132	(ABC) transporter
LY254_03120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LY254_03130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LY254_03140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LY254_03155	COG1741	Belongs to the pirin family
LY254_03170	COG1773	rubredoxin
LY254_03180	COG3659	wide pore channel activity
LY254_03190	COG0745	RESPONSE REGULATOR receiver
LY254_03195	COG5002	protein histidine kinase activity
LY254_03200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LY254_03210	COG0640	Transcriptional regulator
LY254_03215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LY254_03245	COG2197	response regulator
LY254_03250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LY254_03260	COG0709	Synthesizes selenophosphate from selenide and ATP
LY254_03265	COG1126	abc transporter atp-binding protein
LY254_03270	COG0765	amino acid transport
LY254_03275	COG4597	amino acid ABC transporter
LY254_03280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LY254_03290	COG0418	dihydroorotase activity
LY254_03365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LY254_03375	COG1115	amino acid carrier protein
LY254_03395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LY254_03405	COG0799	negative regulation of ribosome biogenesis
LY254_03420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LY254_03460	COG0387	Pfam Sodium calcium exchanger
LY254_03500	COG0432	Pfam Uncharacterised protein family UPF0047
LY254_03580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LY254_03580	COG0574	Belongs to the PEP-utilizing enzyme family
LY254_03595	COG3383	formate dehydrogenase (NAD+) activity
LY254_03605	COG3259	Nickel-dependent hydrogenase
LY254_03615	COG0375	protein maturation
LY254_03620	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LY254_03625	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LY254_03650	COG2197	response regulator
LY254_03660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LY254_03685	COG3706	GGDEF domain
LY254_03695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LY254_03700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LY254_03710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LY254_03765	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LY254_03805	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LY254_03810	COG0271	Belongs to the BolA IbaG family
LY254_03820	COG0318	PFAM AMP-dependent synthetase and ligase
LY254_03820	COG0204	Acyl-transferase
LY254_03825	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LY254_03850	COG1074	ATP-dependent DNA helicase activity
LY254_03860	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LY254_03860	COG0662	Cupin 2, conserved barrel domain protein
LY254_03885	COG1132	(ABC) transporter
LY254_03890	COG1316	TRANSCRIPTIONal
LY254_03900	COG1285	pathogenesis
LY254_03940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LY254_03945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LY254_03965	COG2161	toxin-antitoxin pair type II binding
LY254_03970	COG4115	mRNA cleavage
LY254_03980	COG1054	Belongs to the UPF0176 family
LY254_03985	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LY254_03990	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LY254_03995	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LY254_04000	COG0019	diaminopimelate decarboxylase activity
LY254_04005	COG0456	acetyltransferase
LY254_04010	COG0542	response to heat
LY254_04070	COG0371	Dehydrogenase
LY254_04075	COG2267	carboxylic ester hydrolase activity
LY254_04085	COG0575	Belongs to the CDS family
LY254_04090	COG2242	protein methyltransferase activity
LY254_04090	COG2241	protein methyltransferase activity
LY254_04095	COG1982	Orn Lys Arg decarboxylase major
LY254_04100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LY254_04110	COG2337	Toxic component of a toxin-antitoxin (TA) module
LY254_04155	COG2274	protein secretion by the type I secretion system
LY254_04165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LY254_04170	COG1187	pseudouridine synthase activity
LY254_04180	COG1640	4-alpha-glucanotransferase
LY254_04185	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
LY254_04200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LY254_04210	COG0308	aminopeptidase N
LY254_04230	COG2205	protein histidine kinase activity
LY254_04245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LY254_04250	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LY254_04255	COG3429	Glucose-6-phosphate dehydrogenase subunit
LY254_04255	COG3409	Peptidoglycan-binding domain 1 protein
LY254_04260	COG1797	cobyrinic acid a,c-diamide synthase activity
LY254_04265	COG0406	alpha-ribazole phosphatase activity
LY254_04270	COG1254	Belongs to the acylphosphatase family
LY254_04290	COG0142	geranyltranstransferase activity
LY254_04300	COG1480	7TM receptor with intracellular HD hydrolase
LY254_04310	COG0564	pseudouridine synthase activity
LY254_04325	COG1799	cell septum assembly
LY254_04360	COG0436	Aminotransferase
LY254_04365	COG0395	ABC-type sugar transport system, permease component
LY254_04370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LY254_04380	COG1543	Belongs to the glycosyl hydrolase 57 family
LY254_04390	COG0644	oxidoreductase
LY254_04395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LY254_04410	COG0516	GMP reductase activity
LY254_04415	COG3118	belongs to the thioredoxin family
LY254_04425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LY254_04430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LY254_04430	COG0116	Belongs to the methyltransferase superfamily
LY254_04440	COG2010	Cytochrome c
LY254_04445	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LY254_04460	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LY254_04465	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LY254_04485	COG2166	iron-sulfur cluster assembly
LY254_04490	COG0460	homoserine dehydrogenase
LY254_04500	COG0747	negative chemotaxis
LY254_04505	COG0601	transmembrane transport
LY254_04560	COG0012	GTP binding
LY254_04570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LY254_04580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LY254_04585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LY254_04600	COG0194	GDP metabolic process
LY254_04605	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LY254_04610	COG0805	protein transport
LY254_04620	COG0723	plastoquinol--plastocyanin reductase activity
LY254_04625	COG0739	heme binding
LY254_04630	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LY254_04650	COG0248	Ppx GppA phosphatase
LY254_04655	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LY254_04660	COG1619	proteins homologs of microcin C7 resistance protein MccF
LY254_04665	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LY254_04680	COG1028	Short-chain dehydrogenase reductase Sdr
LY254_04690	COG0459	protein refolding
LY254_04700	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
LY254_04720	COG0109	protoheme IX farnesyltransferase activity
LY254_04725	COG1612	heme a metabolic process
LY254_04735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LY254_04740	COG1845	cytochrome c oxidase, subunit III
LY254_04775	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LY254_04790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LY254_04795	COG1007	ATP synthesis coupled electron transport
LY254_04800	COG1136	(ABC) transporter
LY254_04805	COG0739	heme binding
LY254_04820	COG3118	belongs to the thioredoxin family
LY254_04825	COG1842	Phage shock protein A
LY254_04835	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LY254_04840	COG0438	transferase activity, transferring glycosyl groups
LY254_04845	COG0697	spore germination
LY254_04850	COG0616	signal peptide processing
LY254_04865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LY254_04870	COG0594	ribonuclease P activity
LY254_04880	COG0706	membrane insertase activity
LY254_04890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LY254_04940	COG3781	membrane
LY254_04945	COG1104	cysteine desulfurase activity
LY254_04950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LY254_04960	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LY254_04970	COG0134	indole-3-glycerol-phosphate synthase activity
LY254_04975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LY254_04980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LY254_04995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LY254_05000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LY254_05005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LY254_05010	COG0285	dihydrofolate synthase activity
LY254_05045	COG4948	Mandelate Racemase Muconate Lactonizing
LY254_05050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LY254_05055	COG1181	Belongs to the D-alanine--D-alanine ligase family
LY254_05070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LY254_05085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LY254_05090	COG4956	integral membrane protein (PIN domain superfamily)
LY254_05095	COG0740	serine-type endopeptidase activity
LY254_05100	COG0740	serine-type endopeptidase activity
LY254_05105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LY254_05110	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LY254_05115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LY254_05120	COG0438	transferase activity, transferring glycosyl groups
LY254_05145	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LY254_05220	COG0658	competence protein
LY254_05220	COG2333	competence protein COMEC
LY254_05225	COG0752	glycyl-tRNA synthetase alpha subunit
LY254_05240	COG3128	pkhd-type hydroxylase
LY254_05255	COG3659	wide pore channel activity
LY254_05260	COG2226	methyltransferase
LY254_05270	COG0107	imidazoleglycerol-phosphate synthase activity
LY254_05280	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LY254_05290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LY254_05290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LY254_05295	COG3695	enzyme binding
LY254_05300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LY254_05335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LY254_05340	COG2274	protein secretion by the type I secretion system
LY254_05415	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LY254_05420	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LY254_05425	COG0579	oxidoreductase
LY254_05430	COG0750	zinc metalloprotease
LY254_05435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LY254_05440	COG1185	polyribonucleotide nucleotidyltransferase activity
LY254_05445	COG1218	3'(2'),5'-bisphosphate nucleotidase
LY254_05450	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LY254_05480	COG0484	heat shock protein binding
LY254_05485	COG4243	Vitamin k epoxide reductase
LY254_05530	COG0116	Belongs to the methyltransferase superfamily
LY254_05535	COG3263	regulation of cellular component size
LY254_05550	COG1196	nuclear chromosome segregation
LY254_05560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LY254_05565	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LY254_05575	COG0439	Biotin carboxylase
LY254_05590	COG0515	serine threonine protein kinase
LY254_05610	COG4178	(ABC) transporter
LY254_05615	COG0537	adenosine 5'-monophosphoramidase activity
LY254_05630	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LY254_05645	COG0242	peptide deformylase activity
LY254_05650	COG1073	alpha beta
LY254_05660	COG0235	Class ii aldolase
LY254_05665	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LY254_05680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LY254_05685	COG0719	Fe-S assembly protein
LY254_05690	COG0396	ATPase activity
LY254_05695	COG0719	Fe-S assembly protein
LY254_05700	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
LY254_05725	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LY254_05765	COG0033	Phosphoglucomutase
LY254_05780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LY254_05795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LY254_05800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LY254_05805	COG0175	sulfate reduction
LY254_05810	COG1252	NADH dehydrogenase
LY254_05820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LY254_05825	COG0450	alkyl hydroperoxide reductase
LY254_05830	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LY254_05840	COG0488	(ABC) transporter
LY254_05850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LY254_05865	COG1643	Atp-dependent helicase
LY254_05880	COG1570	exodeoxyribonuclease VII activity
LY254_05935	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LY254_05940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LY254_05945	COG0793	Belongs to the peptidase S41A family
LY254_05950	COG1078	dGTPase activity
LY254_05955	COG0850	regulation of cytokinetic process
LY254_05960	COG2059	Chromate
LY254_05970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LY254_05975	COG2894	cell division
LY254_05980	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LY254_05995	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LY254_06015	COG0189	ligase activity
LY254_06020	COG0697	spore germination
LY254_06070	COG0463	Glycosyl transferase, family 2
LY254_06075	COG5505	Protein of unknown function (DUF819)
LY254_06095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LY254_06105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LY254_06110	COG0254	rRNA binding
LY254_06115	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LY254_06120	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LY254_06125	COG0101	tRNA pseudouridine synthase activity
LY254_06130	COG0203	ribosomal protein L17
LY254_06135	COG0202	RNA polymerase activity
LY254_06140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LY254_06145	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LY254_06150	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LY254_06155	COG0563	adenylate kinase activity
LY254_06160	COG0201	protein transport
LY254_06165	COG0200	Binds to the 23S rRNA
LY254_06170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LY254_06175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LY254_06180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LY254_06190	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LY254_06195	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LY254_06200	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LY254_06205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LY254_06210	COG0255	Belongs to the universal ribosomal protein uL29 family
LY254_06215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LY254_06220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LY254_06225	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LY254_06230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LY254_06235	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LY254_06240	COG0089	rRNA binding
LY254_06245	COG0088	Forms part of the polypeptide exit tunnel
LY254_06250	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LY254_06265	COG3854	ATPases associated with a variety of cellular activities
LY254_06305	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
LY254_06310	COG3001	Fructosamine kinase
LY254_06330	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LY254_06335	COG1606	tRNA processing
LY254_06345	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LY254_06350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LY254_06365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LY254_06370	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LY254_06375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LY254_06390	COG0772	Belongs to the SEDS family
LY254_06395	COG0489	protein tyrosine kinase activity
LY254_06400	COG0408	coproporphyrinogen oxidase activity
LY254_06420	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LY254_06460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LY254_06465	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LY254_06470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LY254_06470	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LY254_06475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LY254_06480	COG1413	lyase activity
LY254_06530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LY254_06555	COG1070	Carbohydrate kinase
LY254_06560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LY254_06570	COG0539	negative regulation of cytoplasmic translation
LY254_06575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LY254_06600	COG0589	response to stress
LY254_06605	COG0824	Thioesterase
LY254_06615	COG2890	protein-(glutamine-N5) methyltransferase activity
LY254_06620	COG0009	L-threonylcarbamoyladenylate synthase
LY254_06630	COG2885	chlorophyll binding
LY254_06635	COG2885	chlorophyll binding
LY254_06655	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LY254_06665	COG0069	glutamate synthase activity
LY254_06665	COG0070	glutamate synthase
LY254_06665	COG0067	glutamate synthase
LY254_06680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LY254_06685	COG0049	tRNA binding
LY254_06695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LY254_06700	COG0051	transcription antitermination factor activity, RNA binding
LY254_06710	COG2226	methyltransferase
LY254_06715	COG1605	Chorismate mutase
LY254_06715	COG0077	Prephenate dehydratase
LY254_06725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LY254_06730	COG1530	ribonuclease E activity
LY254_06740	COG0436	Aminotransferase
LY254_06745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LY254_06760	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LY254_06770	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LY254_06775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LY254_06790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LY254_06795	COG0529	Catalyzes the synthesis of activated sulfate
LY254_06795	COG2046	Belongs to the sulfate adenylyltransferase family
LY254_06810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LY254_06815	COG3536	Protein conserved in bacteria
LY254_06840	COG0540	Belongs to the ATCase OTCase family
LY254_06845	COG2094	Belongs to the DNA glycosylase MPG family
LY254_06860	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LY254_06880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LY254_06900	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LY254_06915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LY254_06920	COG0741	lytic transglycosylase activity
LY254_06935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LY254_06945	COG0717	Belongs to the dCTP deaminase family
LY254_06955	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LY254_06960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LY254_06965	COG4372	Transposase
LY254_06980	COG0193	aminoacyl-tRNA hydrolase activity
LY254_06985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LY254_07020	COG0066	3-isopropylmalate dehydratase activity
LY254_07025	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LY254_07030	COG1546	Belongs to the CinA family
LY254_07030	COG1058	Belongs to the CinA family
LY254_07035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LY254_07040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LY254_07065	COG0728	peptidoglycan biosynthetic process
LY254_07070	COG1489	DNA binding
LY254_07075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LY254_07090	COG0138	bifunctional purine biosynthesis protein purh
LY254_07115	COG0343	queuine tRNA-ribosyltransferase activity
LY254_07135	COG0673	inositol 2-dehydrogenase activity
LY254_07140	COG1253	flavin adenine dinucleotide binding
LY254_07155	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LY254_07170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LY254_07175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LY254_07190	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
LY254_07195	COG0131	Imidazoleglycerol-phosphate dehydratase
LY254_07200	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LY254_07205	COG0415	Belongs to the DNA photolyase family
LY254_07230	COG0415	Belongs to the DNA photolyase family
LY254_07235	COG0494	nUDIX hydrolase
LY254_07240	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LY254_07245	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LY254_07245	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LY254_07260	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LY254_07265	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LY254_07270	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LY254_07275	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LY254_07280	COG1773	rubredoxin
LY254_07285	COG4447	cellulose binding
LY254_07320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LY254_07355	COG2226	methyltransferase
LY254_07370	COG0367	asparagine synthase
LY254_07410	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
LY254_07420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LY254_07430	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LY254_07465	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LY254_07475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LY254_07480	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LY254_07520	COG0463	Glycosyl transferase, family 2
LY254_07540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LY254_07575	COG1132	(ABC) transporter
LY254_07605	COG0463	Glycosyl transferase, family 2
LY254_07630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LY254_07635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LY254_07640	COG0438	transferase activity, transferring glycosyl groups
LY254_07650	COG0124	histidyl-tRNA synthetase
LY254_07655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LY254_07665	COG0617	tRNA 3'-terminal CCA addition
LY254_07675	COG1132	(ABC) transporter
LY254_07695	COG5398	heme oxygenase
LY254_07705	COG0538	isocitrate dehydrogenase activity
LY254_07730	COG2192	nodulation
LY254_07740	COG0531	amino acid
LY254_07750	COG0277	FAD linked oxidase domain protein
LY254_07760	COG1215	transferase activity, transferring glycosyl groups
LY254_07780	COG0724	RNA recognition motif
LY254_07785	COG0165	Argininosuccinate lyase
LY254_07790	COG2208	phosphoserine phosphatase activity
LY254_07795	COG0552	protein localization to endoplasmic reticulum
LY254_07800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LY254_07815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LY254_07825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LY254_07835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LY254_07840	COG0497	DNA recombination
LY254_07845	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LY254_07855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LY254_07860	COG0592	DNA-directed DNA polymerase activity
LY254_07875	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LY254_07895	COG2082	Precorrin-8x methylmutase
LY254_07900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LY254_07910	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LY254_07930	COG1091	dTDP-4-dehydrorhamnose reductase activity
LY254_07940	COG0653	protein targeting
LY254_07945	COG1045	serine acetyltransferase
LY254_07955	COG1725	Transcriptional regulator
LY254_07960	COG0412	Dienelactone hydrolase
LY254_07965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LY254_07970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LY254_07975	COG0187	DNA topoisomerase II activity
LY254_07975	COG1372	Participates in initiation and elongation during chromosome replication
LY254_07985	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LY254_07990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LY254_07995	COG0386	Belongs to the glutathione peroxidase family
LY254_08000	COG2239	Acts as a magnesium transporter
LY254_08005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LY254_08020	COG0802	atpase or kinase
LY254_08025	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LY254_08030	COG0629	single-stranded DNA binding
LY254_08040	COG1792	Involved in formation and maintenance of cell shape
LY254_08055	COG0745	RESPONSE REGULATOR receiver
LY254_08060	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LY254_08090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LY254_08100	COG0515	serine threonine protein kinase
LY254_08120	COG1473	amidohydrolase
LY254_08135	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LY254_08140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LY254_08145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LY254_08150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LY254_08155	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LY254_08160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LY254_08165	COG0662	Cupin 2, conserved barrel domain protein
LY254_08165	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LY254_08170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LY254_08180	COG0571	ribonuclease III activity
LY254_08240	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LY254_08245	COG0058	SHG alpha-glucan phosphorylase activity
LY254_08250	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LY254_08255	COG0475	glutathione-regulated potassium exporter activity
LY254_08265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LY254_08270	COG2081	HI0933 family
LY254_08275	COG1459	type II secretion system
LY254_08285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LY254_08290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LY254_08295	COG0484	heat shock protein binding
LY254_08305	COG1162	GTPase activity
LY254_08310	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LY254_08315	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LY254_08320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LY254_08325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LY254_08330	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LY254_08335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LY254_08340	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LY254_08345	COG0511	ligase activity, forming carbon-carbon bonds
LY254_08350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LY254_08375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LY254_08420	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LY254_08425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LY254_08425	COG0519	Catalyzes the synthesis of GMP from XMP
LY254_08465	COG0768	penicillin binding
LY254_08470	COG0438	transferase activity, transferring glycosyl groups
LY254_08475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LY254_08485	COG2022	thiamine diphosphate biosynthetic process
LY254_08500	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LY254_08505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LY254_08510	COG2385	sporulation resulting in formation of a cellular spore
LY254_08515	COG1215	transferase activity, transferring glycosyl groups
LY254_08520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LY254_08530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LY254_08535	COG0740	serine-type endopeptidase activity
LY254_08540	COG0544	peptidyl-prolyl cis-trans isomerase activity
LY254_08545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LY254_08550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LY254_08555	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LY254_08565	COG0037	tRNA processing
LY254_08575	COG0556	nucleotide-excision repair
LY254_08580	COG0438	transferase activity, transferring glycosyl groups
LY254_08585	COG1316	TRANSCRIPTIONal
LY254_08590	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LY254_08620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LY254_08635	COG0137	argininosuccinate synthase activity
LY254_08645	COG0360	Binds together with S18 to 16S ribosomal RNA
LY254_08655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LY254_08660	COG0443	Heat shock 70 kDa protein
LY254_08665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LY254_08680	COG0788	formyltetrahydrofolate deformylase activity
LY254_08700	COG1049	propionate catabolic process, 2-methylcitrate cycle
LY254_08705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LY254_08715	COG0170	dolichyl monophosphate biosynthetic process
LY254_08720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LY254_08725	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LY254_08735	COG0315	cyclic pyranopterin monophosphate synthase activity
LY254_08740	COG0303	'Molybdopterin
LY254_08745	COG0314	molybdopterin synthase activity
LY254_08755	COG0521	Mo-molybdopterin cofactor biosynthetic process
LY254_08760	COG0730	response to heat
LY254_08765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LY254_08770	COG0746	molybdenum cofactor guanylyltransferase activity
LY254_08775	COG2223	nitrite transmembrane transporter activity
LY254_08780	COG0243	molybdopterin cofactor binding
LY254_08795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LY254_08800	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
LY254_08810	COG2116	formate transmembrane transporter activity
LY254_08815	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LY254_08830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LY254_08845	COG0531	amino acid
LY254_08855	COG0804	urea catabolic process
LY254_08860	COG0832	Belongs to the urease beta subunit family
LY254_08865	COG0831	urea catabolic process
LY254_08870	COG0829	nickel cation binding
LY254_08875	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LY254_08880	COG0830	nickel cation binding
LY254_08885	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LY254_08925	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LY254_08930	COG0602	queuosine metabolic process
LY254_08935	COG0504	CTP synthase activity
LY254_08940	COG0783	Belongs to the Dps family
LY254_08945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LY254_08950	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LY254_08955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LY254_08970	COG0010	Belongs to the arginase family
LY254_08975	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LY254_08985	COG3956	TIGRFAM MazG family protein
LY254_09010	COG0659	secondary active sulfate transmembrane transporter activity
LY254_09015	COG0300	oxidoreductase activity
LY254_09020	COG2226	methyltransferase
LY254_09040	COG0525	valine-tRNA ligase activity
LY254_09045	COG0398	Pfam SNARE associated Golgi protein
LY254_09055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LY254_09090	COG0445	tRNA wobble uridine modification
LY254_09095	COG1372	Participates in initiation and elongation during chromosome replication
LY254_09095	COG1372	Participates in initiation and elongation during chromosome replication
LY254_09095	COG0305	Participates in initiation and elongation during chromosome replication
LY254_09095	COG0305	Participates in initiation and elongation during chromosome replication
LY254_09100	COG0359	binds to the 23S rRNA
LY254_09120	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LY254_09125	COG0509	glycine decarboxylation via glycine cleavage system
LY254_09130	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LY254_09130	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LY254_09145	COG0426	domain, Protein
LY254_09145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LY254_09150	COG0426	domain, Protein
LY254_09150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LY254_09155	COG0071	Belongs to the small heat shock protein (HSP20) family
LY254_09195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LY254_09205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LY254_09235	COG1166	arginine decarboxylase activity
LY254_09240	COG0105	UTP biosynthetic process
LY254_09255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LY254_09255	COG2022	thiamine diphosphate biosynthetic process
LY254_09260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LY254_09270	COG0237	dephospho-CoA kinase activity
LY254_09275	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LY254_09290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LY254_09295	COG0148	phosphopyruvate hydratase activity
LY254_09300	COG0346	lactoylglutathione lyase activity
LY254_09305	COG0542	response to heat
LY254_09310	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LY254_09315	COG0250	Participates in transcription elongation, termination and antitermination
LY254_09320	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LY254_09325	COG0081	regulation of translation
LY254_09330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LY254_09335	COG0222	ribosome binding
LY254_09345	COG0328	RNA-DNA hybrid ribonuclease activity
LY254_09350	COG0167	dihydroorotate dehydrogenase activity
LY254_09380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LY254_09385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LY254_09420	COG0126	phosphoglycerate kinase activity
LY254_09425	COG0589	response to stress
LY254_09435	COG0564	pseudouridine synthase activity
LY254_09440	COG4172	Belongs to the ABC transporter superfamily
LY254_09445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LY254_09450	COG2140	Oxalate decarboxylase
LY254_09465	COG4106	trans-aconitate 2-methyltransferase activity
LY254_09475	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LY254_09480	COG0157	Belongs to the NadC ModD family
LY254_09485	COG0018	arginyl-trna synthetase
LY254_09490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LY254_09500	COG0512	Glutamine amidotransferase of anthranilate synthase
LY254_09505	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LY254_09510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LY254_09525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LY254_09530	COG0189	ligase activity
LY254_09540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LY254_09550	COG1575	Belongs to the MenA family. Type 1 subfamily
LY254_09560	COG0318	PFAM AMP-dependent synthetase and ligase
LY254_09590	COG0649	NAD binding
LY254_09605	COG1104	cysteine desulfurase activity
LY254_09615	COG0745	RESPONSE REGULATOR receiver
LY254_09620	COG0564	pseudouridine synthase activity
LY254_09625	COG0564	pseudouridine synthase activity
LY254_09630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LY254_09635	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LY254_09640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LY254_09645	COG0628	permease
LY254_09650	COG0529	Catalyzes the synthesis of activated sulfate
LY254_09655	COG0023	Translation Initiation Factor
LY254_09665	COG0133	tryptophan synthase activity
LY254_09670	COG1420	regulation of RNA biosynthetic process
LY254_09675	COG1132	(ABC) transporter
LY254_09680	COG1054	Belongs to the UPF0176 family
LY254_09690	COG2062	phosphohistidine phosphatase, SixA
LY254_09695	COG0372	Belongs to the citrate synthase family
LY254_09700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LY254_09705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LY254_09710	COG0839	Belongs to the complex I subunit 6 family
LY254_09715	COG0713	ATP synthesis coupled electron transport
LY254_09720	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LY254_09740	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LY254_09755	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LY254_09760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LY254_09770	COG0583	DNA-binding transcription factor activity
LY254_09785	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LY254_09785	COG0493	'glutamate synthase
LY254_09790	COG1562	ergosterol biosynthetic process
LY254_09835	COG1136	(ABC) transporter
LY254_09860	COG0724	RNA recognition motif
LY254_09875	COG1214	PFAM Peptidase M22, glycoprotease
LY254_09890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LY254_09895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LY254_09900	COG0416	fatty acid biosynthetic process
LY254_09910	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LY254_09915	COG0457	Tetratricopeptide repeat
LY254_09920	COG2217	Heavy metal translocating P-type atpase
LY254_09925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LY254_09935	COG0745	RESPONSE REGULATOR receiver
LY254_09945	COG1122	ATPase activity
LY254_09960	COG2132	Multicopper oxidase
LY254_09970	COG0463	Glycosyl transferase, family 2
LY254_09985	COG3659	wide pore channel activity
LY254_09990	COG3659	wide pore channel activity
LY254_09995	COG3659	wide pore channel activity
LY254_10000	COG0484	heat shock protein binding
LY254_10010	COG1090	epimerase
LY254_10030	COG0316	Belongs to the HesB IscA family
LY254_10035	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LY254_10050	COG1587	Uroporphyrinogen-III synthase
LY254_10055	COG0463	Glycosyl transferase, family 2
LY254_10055	COG0457	Tetratricopeptide repeat
LY254_10060	COG1472	Belongs to the glycosyl hydrolase 3 family
LY254_10065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LY254_10090	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LY254_10120	COG1032	radical SAM domain protein
LY254_10135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LY254_10140	COG4243	Vitamin k epoxide reductase
LY254_10145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LY254_10150	COG1555	photosystem II stabilization
LY254_10160	COG1968	undecaprenyl-diphosphatase activity
LY254_10180	COG0483	inositol monophosphate 1-phosphatase activity
LY254_10215	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LY254_10225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LY254_10240	COG0514	ATP-dependent DNA helicase (RecQ)
LY254_10245	COG3942	CHAP domain
LY254_10245	COG1388	LysM domain
LY254_10250	COG1012	belongs to the aldehyde dehydrogenase family
LY254_10285	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LY254_10315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LY254_10330	COG1160	GTP binding
LY254_10335	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LY254_10345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LY254_10350	COG1799	cell septum assembly
LY254_10355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LY254_10360	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LY254_10375	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LY254_10380	COG2211	Major facilitator Superfamily
LY254_10390	COG1523	belongs to the glycosyl hydrolase 13 family
LY254_10400	COG0776	regulation of translation
LY254_10420	COG0113	porphobilinogen synthase activity
LY254_10445	COG1193	negative regulation of DNA recombination
LY254_10450	COG3842	ATPase activity
LY254_10455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LY254_10470	COG0488	(ABC) transporter
LY254_10480	COG0435	Glutathione S-transferase
LY254_10485	COG2988	succinylglutamate desuccinylase activity
LY254_10500	COG0028	Belongs to the TPP enzyme family
LY254_10505	COG3527	Alpha-acetolactate decarboxylase
LY254_10540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LY254_10550	COG0195	Participates in both transcription termination and antitermination
LY254_10555	COG0779	Required for maturation of 30S ribosomal subunits
LY254_10565	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LY254_10570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LY254_10575	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LY254_10580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LY254_10585	COG0268	Binds directly to 16S ribosomal RNA
LY254_10590	COG0084	hydrolase, TatD family'
LY254_10595	COG0085	RNA polymerase activity
LY254_10600	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LY254_10605	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LY254_10610	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LY254_10615	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LY254_10650	COG0357	Ribosomal RNA small subunit methyltransferase G
LY254_10655	COG0484	heat shock protein binding
LY254_10670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LY254_10685	COG0156	8-amino-7-oxononanoate synthase activity
LY254_10690	COG4581	dead DEAH box helicase
LY254_10695	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LY254_10700	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LY254_10710	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LY254_10715	COG0347	Belongs to the P(II) protein family
LY254_10720	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LY254_10725	COG1333	cytochrome c biogenesis protein
LY254_10735	COG0772	Belongs to the SEDS family
LY254_10755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LY254_10760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LY254_10780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LY254_10810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LY254_10820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LY254_10825	COG3012	SEC-C Motif Domain Protein
LY254_10830	COG0686	Belongs to the AlaDH PNT family
LY254_10835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LY254_10835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LY254_10840	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LY254_10845	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LY254_10850	COG0006	proline dipeptidase activity
LY254_10880	COG0515	serine threonine protein kinase
LY254_10895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LY254_10905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LY254_10910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LY254_10915	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LY254_10920	COG0459	protein refolding
LY254_10940	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LY254_10950	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LY254_10955	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LY254_10970	COG0443	Heat shock 70 kDa protein
LY254_11010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LY254_11030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LY254_11035	COG2264	protein methyltransferase activity
LY254_11050	COG2010	Cytochrome c
LY254_11055	COG1234	tRNA 3'-trailer cleavage
LY254_11060	COG2385	sporulation resulting in formation of a cellular spore
LY254_11065	COG0363	glucosamine-6-phosphate deaminase activity
LY254_11070	COG0217	transcriptional regulatory protein
LY254_11075	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LY254_11080	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LY254_11085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LY254_11090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LY254_11095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LY254_11105	COG4251	negative regulation of phosphorylation
LY254_11110	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
LY254_11115	COG5002	protein histidine kinase activity
LY254_11120	COG0151	Belongs to the GarS family
LY254_11130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LY254_11135	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LY254_11140	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LY254_11145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LY254_11150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LY254_11155	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LY254_11160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LY254_11175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LY254_11190	COG2197	response regulator
LY254_11200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LY254_11205	COG0288	reversible hydration of carbon dioxide
LY254_11215	COG0284	orotidine-5'-phosphate decarboxylase activity
LY254_11220	COG0438	transferase activity, transferring glycosyl groups
LY254_11235	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LY254_11240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LY254_11245	COG0321	lipoyl(octanoyl) transferase activity
LY254_11250	COG1022	Amp-dependent synthetase and ligase
LY254_11260	COG0508	dehydrogenase complex catalyzes the overall conversion of
LY254_11265	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LY254_11270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LY254_11300	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LY254_11330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LY254_11335	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LY254_11340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LY254_11345	COG2135	peptidase activity
LY254_11350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LY254_11355	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LY254_11355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LY254_11385	COG0745	RESPONSE REGULATOR receiver
LY254_11390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LY254_11395	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LY254_11400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LY254_11410	COG0196	riboflavin kinase activity
LY254_11440	COG1691	(AIR) carboxylase
LY254_11450	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LY254_11470	COG0330	HflC and HflK could
LY254_11475	COG0336	Belongs to the RNA methyltransferase TrmD family
LY254_11485	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LY254_11500	COG1702	phosphate starvation-inducible protein PhoH
LY254_11505	COG0228	four-way junction DNA binding
LY254_11510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LY254_11520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LY254_11525	COG0123	including yeast histone deacetylase and acetoin utilization protein
LY254_11540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LY254_11545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LY254_11545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LY254_11550	COG0482	sulfurtransferase activity
LY254_11570	COG1492	cobalamin metabolic process
LY254_11615	COG0424	maF-like protein
LY254_11690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LY254_11695	COG0440	acetolactate synthase activity
LY254_11775	COG1187	pseudouridine synthase activity
LY254_11835	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LY254_11845	COG0733	neurotransmitter:sodium symporter activity
LY254_11855	COG0215	cysteine-tRNA ligase activity
LY254_11895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LY254_11895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LY254_11915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LY254_11935	COG0335	large ribosomal subunit rRNA binding
LY254_11945	COG0024	Methionine aminopeptidase
LY254_11950	COG3000	fatty acid hydroxylase
LY254_11950	COG0300	oxidoreductase activity
LY254_11960	COG0857	belongs to the CobB CobQ family
LY254_11975	COG1666	GTP binding
LY254_11990	COG0405	Gamma-glutamyltransferase
LY254_11995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LY254_12005	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LY254_12010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LY254_12015	COG0277	FAD linked oxidase domain protein
LY254_12020	COG0708	Exodeoxyribonuclease III
LY254_12045	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
LY254_12055	COG0735	belongs to the Fur family
LY254_12070	COG0523	cobalamin synthesis protein
LY254_12090	COG1121	(ABC) transporter
LY254_12100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LY254_12120	COG0720	synthase
LY254_12125	COG0140	phosphoribosyl-ATP diphosphatase activity
LY254_12125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LY254_12130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LY254_12150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LY254_12155	COG3339	Conserved Protein
LY254_12200	COG2010	Cytochrome c
LY254_12215	COG0159	tryptophan synthase activity
LY254_12240	COG1053	succinate dehydrogenase
LY254_12265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LY254_12270	COG1845	cytochrome c oxidase, subunit III
LY254_12325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LY254_12350	COG1840	ABC-type Fe3 transport system, periplasmic component
LY254_12355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LY254_12375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LY254_12475	COG2226	methyltransferase
LY254_12485	COG0778	Nitroreductase
LY254_12490	COG2113	Glycine betaine
LY254_12495	COG4176	ABC-type proline glycine betaine transport system permease component
LY254_12500	COG4175	Glycine betaine
LY254_12505	COG2226	methyltransferase
LY254_12510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LY254_12525	COG0540	Belongs to the ATCase OTCase family
LY254_12530	COG0367	asparagine synthase
LY254_12555	COG2326	polyphosphate kinase activity
LY254_12660	COG3781	membrane
LY254_12695	COG0659	secondary active sulfate transmembrane transporter activity
LY254_12825	COG2124	cytochrome p450
LY254_12890	COG4942	peptidase
LY254_12900	COG0251	oxidation-reduction process
LY254_12910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LY254_12915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LY254_12920	COG1132	(ABC) transporter
LY254_12930	COG0456	acetyltransferase
LY254_12945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain