locus-tag	class	description
NIES970_00010	COG1132	(ABC) transporter
NIES970_00020	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NIES970_00030	COG0123	including yeast histone deacetylase and acetoin utilization protein
NIES970_00050	COG0673	inositol 2-dehydrogenase activity
NIES970_00060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIES970_00070	COG0633	Ferredoxin
NIES970_00080	COG1234	tRNA 3'-trailer cleavage
NIES970_00130	COG0312	modulator of DNA gyrase
NIES970_00140	COG2154	pterin-4-alpha-carbinolamine dehydratase
NIES970_00150	COG3659	wide pore channel activity
NIES970_00160	COG2084	Dehydrogenase
NIES970_00170	COG2203	Gaf domain
NIES970_00170	COG5001	Diguanylate cyclase
NIES970_00170	COG3706	GGDEF domain
NIES970_00170	COG4251	negative regulation of phosphorylation
NIES970_00180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NIES970_00210	COG1543	Belongs to the glycosyl hydrolase 57 family
NIES970_00250	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NIES970_00260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NIES970_00290	COG4956	integral membrane protein (PIN domain superfamily)
NIES970_00300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NIES970_00310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIES970_00330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NIES970_00340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NIES970_00360	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NIES970_00370	COG1022	Amp-dependent synthetase and ligase
NIES970_00390	COG0287	Prephenate dehydrogenase
NIES970_00400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NIES970_00420	COG0804	urea catabolic process
NIES970_00470	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
NIES970_00490	COG3259	Nickel-dependent hydrogenase
NIES970_00520	COG0375	protein maturation
NIES970_00530	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NIES970_00540	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
NIES970_00560	COG0298	carbon dioxide binding
NIES970_00600	COG1490	D-aminoacyl-tRNA deacylase activity
NIES970_00640	COG0583	DNA-binding transcription factor activity
NIES970_00650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NIES970_00660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES970_00680	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NIES970_00690	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NIES970_00690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NIES970_00700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NIES970_00710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NIES970_00810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NIES970_00810	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NIES970_00850	COG2010	Cytochrome c
NIES970_00860	COG0508	dehydrogenase complex catalyzes the overall conversion of
NIES970_00880	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NIES970_00900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NIES970_00910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NIES970_00960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NIES970_00970	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NIES970_00980	COG0019	diaminopimelate decarboxylase activity
NIES970_00990	COG0456	acetyltransferase
NIES970_01000	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NIES970_01010	COG0716	FMN binding
NIES970_01040	COG0708	Exodeoxyribonuclease III
NIES970_01050	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NIES970_01110	COG0672	)-iron permease
NIES970_01140	COG1494	fructose-1,6-bisphosphatase
NIES970_01150	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NIES970_01210	COG0745	RESPONSE REGULATOR receiver
NIES970_01220	COG1372	Participates in initiation and elongation during chromosome replication
NIES970_01220	COG0719	Fe-S assembly protein
NIES970_01230	COG0717	Belongs to the dCTP deaminase family
NIES970_01260	COG2223	nitrite transmembrane transporter activity
NIES970_01270	COG0243	molybdopterin cofactor binding
NIES970_01280	COG2239	Acts as a magnesium transporter
NIES970_01300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NIES970_01310	COG0848	biopolymer transport protein
NIES970_01320	COG0811	peptide transport
NIES970_01330	COG0831	urea catabolic process
NIES970_01350	COG0426	domain, Protein
NIES970_01350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIES970_01360	COG3237	CsbD-like
NIES970_01380	COG3237	CsbD-like
NIES970_01410	COG0489	protein tyrosine kinase activity
NIES970_01430	COG2166	iron-sulfur cluster assembly
NIES970_01450	COG1136	(ABC) transporter
NIES970_01470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NIES970_01490	COG0745	RESPONSE REGULATOR receiver
NIES970_01500	COG1691	(AIR) carboxylase
NIES970_01520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NIES970_01530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES970_01550	COG5002	protein histidine kinase activity
NIES970_01580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NIES970_01640	COG0793	Belongs to the peptidase S41A family
NIES970_01660	COG0656	L-ascorbic acid biosynthetic process
NIES970_01680	COG0737	Belongs to the 5'-nucleotidase family
NIES970_01690	COG0668	transmembrane transport
NIES970_01730	COG0756	dUTP diphosphatase activity
NIES970_01760	COG2205	protein histidine kinase activity
NIES970_01760	COG5002	protein histidine kinase activity
NIES970_01760	COG0784	Response regulator, receiver
NIES970_01770	COG0459	protein refolding
NIES970_01800	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NIES970_01830	COG0542	response to heat
NIES970_01850	COG0745	RESPONSE REGULATOR receiver
NIES970_01860	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NIES970_01880	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NIES970_01900	COG0728	peptidoglycan biosynthetic process
NIES970_01910	COG1175	transmembrane transport
NIES970_01930	COG0789	Transcriptional regulator
NIES970_01940	COG0800	Aldolase
NIES970_01960	COG1959	2 iron, 2 sulfur cluster binding
NIES970_01970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIES970_01980	COG1160	GTP binding
NIES970_02000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NIES970_02010	COG4172	Belongs to the ABC transporter superfamily
NIES970_02020	COG0629	single-stranded DNA binding
NIES970_02040	COG0386	Belongs to the glutathione peroxidase family
NIES970_02080	COG3239	Fatty acid desaturase
NIES970_02110	COG0205	6-phosphofructokinase activity
NIES970_02150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NIES970_02160	COG5398	heme oxygenase
NIES970_02170	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NIES970_02180	COG1733	regulation of RNA biosynthetic process
NIES970_02190	COG0410	ABC transporter
NIES970_02200	COG0411	ABC transporter
NIES970_02210	COG0288	reversible hydration of carbon dioxide
NIES970_02220	COG3693	PFAM glycoside hydrolase, family 10
NIES970_02230	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NIES970_02240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NIES970_02250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIES970_02260	COG0784	Response regulator, receiver
NIES970_02290	COG2203	Gaf domain
NIES970_02290	COG0840	transmembrane signaling receptor activity
NIES970_02310	COG0484	heat shock protein binding
NIES970_02340	COG3347	Dehydrogenase
NIES970_02340	COG1028	Short-chain dehydrogenase reductase Sdr
NIES970_02350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NIES970_02360	COG5001	Diguanylate cyclase
NIES970_02360	COG4251	negative regulation of phosphorylation
NIES970_02360	COG2203	Gaf domain
NIES970_02360	COG3706	GGDEF domain
NIES970_02420	COG1193	negative regulation of DNA recombination
NIES970_02440	COG1331	Highly conserved protein containing a thioredoxin domain
NIES970_02460	COG1970	mechanosensitive ion channel activity
NIES970_02470	COG5001	Diguanylate cyclase
NIES970_02480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NIES970_02520	COG0018	arginyl-trna synthetase
NIES970_02540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NIES970_02560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NIES970_02600	COG1253	flavin adenine dinucleotide binding
NIES970_02620	COG0673	inositol 2-dehydrogenase activity
NIES970_02640	COG0339	signal peptide processing
NIES970_02670	COG0542	response to heat
NIES970_02680	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NIES970_02700	COG0285	dihydrofolate synthase activity
NIES970_02750	COG0559	Belongs to the binding-protein-dependent transport system permease family
NIES970_02770	COG1606	tRNA processing
NIES970_02780	COG0747	negative chemotaxis
NIES970_02800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NIES970_02810	COG1214	PFAM Peptidase M22, glycoprotease
NIES970_02840	COG0752	glycyl-tRNA synthetase alpha subunit
NIES970_02860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIES970_02870	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NIES970_02890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NIES970_02930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES970_02950	COG0189	ligase activity
NIES970_02960	COG0189	ligase activity
NIES970_02960	COG4067	protein conserved in archaea
NIES970_03000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIES970_03000	COG2205	protein histidine kinase activity
NIES970_03020	COG1162	GTPase activity
NIES970_03040	COG0484	heat shock protein binding
NIES970_03050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NIES970_03050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NIES970_03080	COG1968	undecaprenyl-diphosphatase activity
NIES970_03120	COG0860	N-Acetylmuramoyl-L-alanine amidase
NIES970_03130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NIES970_03170	COG0142	geranyltranstransferase activity
NIES970_03180	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NIES970_03190	COG2247	cell wall binding repeat
NIES970_03190	COG0860	N-Acetylmuramoyl-L-alanine amidase
NIES970_03200	COG0475	glutathione-regulated potassium exporter activity
NIES970_03230	COG0557	exoribonuclease II activity
NIES970_03240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NIES970_03250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NIES970_03320	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NIES970_03360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NIES970_03440	COG0443	Heat shock 70 kDa protein
NIES970_03470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NIES970_03510	COG0083	homoserine kinase activity
NIES970_03590	COG0612	Peptidase, M16
NIES970_03620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES970_03640	COG3937	granule-associated protein
NIES970_03670	COG1472	Belongs to the glycosyl hydrolase 3 family
NIES970_03680	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NIES970_03690	COG0148	phosphopyruvate hydratase activity
NIES970_03700	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NIES970_03710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NIES970_03720	COG0457	Tetratricopeptide repeat
NIES970_03750	COG0500	methyltransferase
NIES970_03760	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NIES970_03780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NIES970_03790	COG0450	alkyl hydroperoxide reductase
NIES970_03800	COG1555	photosystem II stabilization
NIES970_03820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NIES970_03840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NIES970_03850	COG1032	radical SAM domain protein
NIES970_03860	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NIES970_03870	COG1640	4-alpha-glucanotransferase
NIES970_03890	COG1192	Involved in chromosome partitioning
NIES970_03920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NIES970_03930	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NIES970_03980	COG0574	Belongs to the PEP-utilizing enzyme family
NIES970_03980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NIES970_03990	COG0459	protein refolding
NIES970_04000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NIES970_04010	COG0751	glycine-tRNA ligase activity
NIES970_04020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NIES970_04080	COG0024	Methionine aminopeptidase
NIES970_04120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIES970_04120	COG0426	domain, Protein
NIES970_04130	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NIES970_04140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NIES970_04150	COG3174	membrane
NIES970_04160	COG0484	heat shock protein binding
NIES970_04170	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NIES970_04170	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NIES970_04190	COG1122	ATPase activity
NIES970_04210	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NIES970_04240	COG1127	ABC transporter
NIES970_04280	COG1121	(ABC) transporter
NIES970_04290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NIES970_04300	COG0009	L-threonylcarbamoyladenylate synthase
NIES970_04330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NIES970_04350	COG0012	GTP binding
NIES970_04360	COG0515	serine threonine protein kinase
NIES970_04360	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES970_04370	COG2267	carboxylic ester hydrolase activity
NIES970_04420	COG0095	Lipoate-protein ligase
NIES970_04430	COG0438	transferase activity, transferring glycosyl groups
NIES970_04440	COG1132	(ABC) transporter
NIES970_04460	COG2226	methyltransferase
NIES970_04480	COG2084	Dehydrogenase
NIES970_04490	COG3781	membrane
NIES970_04530	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
NIES970_04540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NIES970_04550	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NIES970_04560	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NIES970_04570	COG0457	Tetratricopeptide repeat
NIES970_04600	COG4783	chaperone-mediated protein folding
NIES970_04620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NIES970_04670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NIES970_04680	COG0542	response to heat
NIES970_04720	COG0025	NhaP-type Na H and K H
NIES970_04760	COG0242	peptide deformylase activity
NIES970_04770	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
NIES970_04800	COG0598	Magnesium transport protein CorA
NIES970_04820	COG0113	porphobilinogen synthase activity
NIES970_04860	COG0170	dolichyl monophosphate biosynthetic process
NIES970_04910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NIES970_04920	COG0512	Glutamine amidotransferase of anthranilate synthase
NIES970_04920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NIES970_04930	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NIES970_04940	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NIES970_04960	COG3239	Fatty acid desaturase
NIES970_04970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NIES970_05040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NIES970_05070	COG3591	Belongs to the peptidase S1B family
NIES970_05080	COG1032	radical SAM domain protein
NIES970_05210	COG0473	3-isopropylmalate dehydrogenase activity
NIES970_05220	COG2081	HI0933 family
NIES970_05240	COG1187	pseudouridine synthase activity
NIES970_05260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NIES970_05270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NIES970_05290	COG4106	trans-aconitate 2-methyltransferase activity
NIES970_05310	COG0539	negative regulation of cytoplasmic translation
NIES970_05330	COG5002	protein histidine kinase activity
NIES970_05330	COG2205	protein histidine kinase activity
NIES970_05330	COG0784	Response regulator, receiver
NIES970_05350	COG1028	Short-chain dehydrogenase reductase Sdr
NIES970_05360	COG3118	belongs to the thioredoxin family
NIES970_05400	COG0575	Belongs to the CDS family
NIES970_05430	COG0644	oxidoreductase
NIES970_05450	COG0438	transferase activity, transferring glycosyl groups
NIES970_05470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NIES970_05510	COG0017	Asparaginyl-tRNA synthetase
NIES970_05540	COG0432	Pfam Uncharacterised protein family UPF0047
NIES970_05570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NIES970_05580	COG1121	(ABC) transporter
NIES970_05590	COG0803	Belongs to the bacterial solute-binding protein 9 family
NIES970_05610	COG3063	Type IV pilus biogenesis stability protein PilW
NIES970_05630	COG0419	ATPase involved in DNA repair
NIES970_05650	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NIES970_05690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIES970_05700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NIES970_05710	COG4581	dead DEAH box helicase
NIES970_05720	COG3447	MASE1 domain protein
NIES970_05720	COG5002	protein histidine kinase activity
NIES970_05720	COG5001	Diguanylate cyclase
NIES970_05750	COG0193	aminoacyl-tRNA hydrolase activity
NIES970_05840	COG0454	-acetyltransferase
NIES970_05860	COG0556	nucleotide-excision repair
NIES970_05870	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NIES970_05930	COG1007	ATP synthesis coupled electron transport
NIES970_05940	COG1754	DNA topoisomerase type I activity
NIES970_05940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NIES970_05960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NIES970_05970	COG0571	ribonuclease III activity
NIES970_05980	COG0649	NAD binding
NIES970_06000	COG0697	spore germination
NIES970_06010	COG0616	signal peptide processing
NIES970_06060	COG0832	Belongs to the urease beta subunit family
NIES970_06070	COG1940	carbohydrate kinase activity
NIES970_06080	COG1309	transcriptional regulator
NIES970_06090	COG0670	Belongs to the BI1 family
NIES970_06100	COG0825	malonyl-CoA metabolic process
NIES970_06110	COG0302	gtp cyclohydrolase
NIES970_06120	COG1902	pentaerythritol trinitrate reductase activity
NIES970_06150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NIES970_06160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIES970_06210	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
NIES970_06220	COG4948	Mandelate Racemase Muconate Lactonizing
NIES970_06240	COG2202	Pas domain
NIES970_06240	COG2205	protein histidine kinase activity
NIES970_06270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NIES970_06280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NIES970_06290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIES970_06300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NIES970_06310	COG0745	RESPONSE REGULATOR receiver
NIES970_06330	COG2003	Belongs to the UPF0758 family
NIES970_06340	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NIES970_06350	COG0312	modulator of DNA gyrase
NIES970_06380	COG0316	Belongs to the HesB IscA family
NIES970_06390	COG0569	domain protein
NIES970_06400	COG1773	rubredoxin
NIES970_06410	COG4447	cellulose binding
NIES970_06470	COG3977	Valine--pyruvate aminotransferase
NIES970_06480	COG0322	excinuclease ABC activity
NIES970_06510	COG1131	(ABC) transporter
NIES970_06530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NIES970_06560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIES970_06580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NIES970_06610	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NIES970_06610	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NIES970_06620	COG0149	triose-phosphate isomerase activity
NIES970_06630	COG1619	proteins homologs of microcin C7 resistance protein MccF
NIES970_06650	COG0750	zinc metalloprotease
NIES970_06670	COG0640	Transcriptional regulator
NIES970_06680	COG0798	PFAM Bile acid sodium symporter
NIES970_06690	COG0431	NADPH-dependent FMN reductase
NIES970_06700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NIES970_06770	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
NIES970_06780	COG0346	lactoylglutathione lyase activity
NIES970_06800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NIES970_06810	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NIES970_06820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NIES970_06820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NIES970_06830	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NIES970_06840	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NIES970_06860	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NIES970_06860	COG0517	IMP dehydrogenase activity
NIES970_06910	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NIES970_06930	COG0105	UTP biosynthetic process
NIES970_06970	COG2226	methyltransferase
NIES970_06980	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NIES970_07010	COG1132	(ABC) transporter
NIES970_07030	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NIES970_07040	COG1446	asparaginase
NIES970_07050	COG0601	transmembrane transport
NIES970_07060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NIES970_07110	COG4206	TonB-dependent receptor
NIES970_07120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NIES970_07170	COG0504	CTP synthase activity
NIES970_07220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NIES970_07240	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NIES970_07250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NIES970_07270	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NIES970_07280	COG0356	it plays a direct role in the translocation of protons across the membrane
NIES970_07330	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NIES970_07340	COG0857	belongs to the CobB CobQ family
NIES970_07360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NIES970_07380	COG0357	Ribosomal RNA small subunit methyltransferase G
NIES970_07400	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NIES970_07420	COG0779	Required for maturation of 30S ribosomal subunits
NIES970_07430	COG0195	Participates in both transcription termination and antitermination
NIES970_07450	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NIES970_07460	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NIES970_07490	COG3639	organic phosphonate transmembrane transporter activity
NIES970_07510	COG0515	serine threonine protein kinase
NIES970_07540	COG0429	hydrolase of the alpha beta-hydrolase fold
NIES970_07550	COG0488	(ABC) transporter
NIES970_07570	COG0463	Glycosyl transferase, family 2
NIES970_07580	COG0681	Belongs to the peptidase S26 family
NIES970_07620	COG0303	'Molybdopterin
NIES970_07710	COG5002	protein histidine kinase activity
NIES970_07720	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NIES970_07760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NIES970_07780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NIES970_07810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NIES970_07820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES970_07830	COG0668	transmembrane transport
NIES970_07840	COG3693	PFAM glycoside hydrolase, family 10
NIES970_07860	COG0497	DNA recombination
NIES970_07870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NIES970_07880	COG4636	protein conserved in cyanobacteria
NIES970_07900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NIES970_07900	COG0072	phenylalanine-tRNA ligase activity
NIES970_07910	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES970_07910	COG0515	serine threonine protein kinase
NIES970_07940	COG0360	Binds together with S18 to 16S ribosomal RNA
NIES970_07970	COG0371	Dehydrogenase
NIES970_07980	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NIES970_08020	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NIES970_08020	COG0284	orotidine-5'-phosphate decarboxylase activity
NIES970_08030	COG0577	efflux transmembrane transporter activity
NIES970_08030	COG1136	(ABC) transporter
NIES970_08050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIES970_08070	COG2197	response regulator
NIES970_08090	COG0251	oxidation-reduction process
NIES970_08100	COG0513	Belongs to the DEAD box helicase family
NIES970_08110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIES970_08120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NIES970_08130	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NIES970_08140	COG0484	heat shock protein binding
NIES970_08150	COG0483	inositol monophosphate 1-phosphatase activity
NIES970_08160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIES970_08180	COG0488	(ABC) transporter
NIES970_08200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NIES970_08210	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NIES970_08220	COG0515	serine threonine protein kinase
NIES970_08220	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES970_08250	COG3659	wide pore channel activity
NIES970_08280	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NIES970_08290	COG1104	cysteine desulfurase activity
NIES970_08300	COG1530	ribonuclease E activity
NIES970_08310	COG3956	TIGRFAM MazG family protein
NIES970_08340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIES970_08360	COG0488	(ABC) transporter
NIES970_08380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NIES970_08390	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NIES970_08400	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES970_08400	COG0515	serine threonine protein kinase
NIES970_08430	COG3659	wide pore channel activity
NIES970_08460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NIES970_08470	COG1104	cysteine desulfurase activity
NIES970_08480	COG1530	ribonuclease E activity
NIES970_08490	COG3956	TIGRFAM MazG family protein
NIES970_08530	COG0678	peroxiredoxin activity
NIES970_08540	COG3273	potassium ion transport
NIES970_08540	COG0471	metal ion transport
NIES970_08550	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NIES970_08570	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NIES970_08580	COG4208	sulfate ABC transporter
NIES970_08590	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NIES970_08610	COG0516	GMP reductase activity
NIES970_08640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NIES970_08660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NIES970_08670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NIES970_08680	COG1028	Short-chain dehydrogenase reductase Sdr
NIES970_08690	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NIES970_08740	COG0673	inositol 2-dehydrogenase activity
NIES970_08760	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NIES970_08770	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NIES970_08790	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NIES970_08800	COG1132	(ABC) transporter
NIES970_08820	COG0277	FAD linked oxidase domain protein
NIES970_08870	COG1196	nuclear chromosome segregation
NIES970_08880	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NIES970_08890	COG2226	methyltransferase
NIES970_08920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NIES970_08950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NIES970_09020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NIES970_09030	COG1333	cytochrome c biogenesis protein
NIES970_09070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NIES970_09110	COG3338	carbonate dehydratase activity
NIES970_09130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NIES970_09140	COG1185	polyribonucleotide nucleotidyltransferase activity
NIES970_09160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NIES970_09190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NIES970_09200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NIES970_09210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NIES970_09220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NIES970_09230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NIES970_09240	COG0255	Belongs to the universal ribosomal protein uL29 family
NIES970_09260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NIES970_09270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NIES970_09280	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NIES970_09290	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NIES970_09300	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NIES970_09310	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NIES970_09320	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NIES970_09330	COG0200	Binds to the 23S rRNA
NIES970_09340	COG0201	protein transport
NIES970_09350	COG0563	adenylate kinase activity
NIES970_09370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NIES970_09390	COG0202	RNA polymerase activity
NIES970_09400	COG0203	ribosomal protein L17
NIES970_09410	COG0101	tRNA pseudouridine synthase activity
NIES970_09420	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NIES970_09430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NIES970_09440	COG0254	rRNA binding
NIES970_09450	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NIES970_09470	COG3659	wide pore channel activity
NIES970_09480	COG0335	large ribosomal subunit rRNA binding
NIES970_09500	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NIES970_09510	COG0250	Participates in transcription elongation, termination and antitermination
NIES970_09520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NIES970_09530	COG0081	regulation of translation
NIES970_09550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NIES970_09560	COG0222	ribosome binding
NIES970_09570	COG0154	amidase activity
NIES970_09580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NIES970_09590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NIES970_09600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NIES970_09640	COG1429	ligase activity, forming nitrogen-metal bonds
NIES970_09670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NIES970_09700	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NIES970_09710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NIES970_09720	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
NIES970_09730	COG4251	negative regulation of phosphorylation
NIES970_09750	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NIES970_09770	COG0436	Aminotransferase
NIES970_09780	COG3118	belongs to the thioredoxin family
NIES970_09790	COG1842	Phage shock protein A
NIES970_09800	COG4251	negative regulation of phosphorylation
NIES970_09810	COG0133	tryptophan synthase activity
NIES970_09860	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NIES970_09870	COG0783	Belongs to the Dps family
NIES970_09910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NIES970_09920	COG0436	Aminotransferase
NIES970_09930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NIES970_09930	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NIES970_09940	COG2205	protein histidine kinase activity
NIES970_09940	COG2202	Pas domain
NIES970_09950	COG1505	serine-type exopeptidase activity
NIES970_09960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NIES970_09970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NIES970_09990	COG0438	transferase activity, transferring glycosyl groups
NIES970_10010	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NIES970_10050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES970_10080	COG0706	membrane insertase activity
NIES970_10100	COG0594	ribonuclease P activity
NIES970_10110	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NIES970_10140	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NIES970_10150	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NIES970_10160	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NIES970_10200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NIES970_10200	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NIES970_10210	COG0745	RESPONSE REGULATOR receiver
NIES970_10220	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NIES970_10230	COG0517	IMP dehydrogenase activity
NIES970_10230	COG1994	Peptidase M50
NIES970_10250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NIES970_10260	COG0745	RESPONSE REGULATOR receiver
NIES970_10280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NIES970_10280	COG0140	phosphoribosyl-ATP diphosphatase activity
NIES970_10290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NIES970_10300	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NIES970_10330	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NIES970_10370	COG0416	fatty acid biosynthetic process
NIES970_10380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NIES970_10400	COG0058	SHG alpha-glucan phosphorylase activity
NIES970_10430	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
NIES970_10440	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NIES970_10450	COG0235	Class ii aldolase
NIES970_10480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NIES970_10490	COG0450	alkyl hydroperoxide reductase
NIES970_10520	COG0159	tryptophan synthase activity
NIES970_10570	COG0484	heat shock protein binding
NIES970_10610	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NIES970_10620	COG0271	Belongs to the BolA IbaG family
NIES970_10640	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NIES970_10650	COG0613	PHP domain protein
NIES970_10660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NIES970_10670	COG0501	Belongs to the peptidase M48B family
NIES970_10700	COG0612	Peptidase, M16
NIES970_10710	COG0443	Heat shock 70 kDa protein
NIES970_10720	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NIES970_10750	COG2211	Major facilitator Superfamily
NIES970_10760	COG0515	serine threonine protein kinase
NIES970_10760	COG3266	domain, Protein
NIES970_10770	COG1070	Carbohydrate kinase
NIES970_10780	COG0720	synthase
NIES970_10790	COG0066	3-isopropylmalate dehydratase activity
NIES970_10800	COG3937	granule-associated protein
NIES970_10810	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NIES970_10820	COG0631	protein serine/threonine phosphatase activity
NIES970_10850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES970_10890	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NIES970_10930	COG0318	PFAM AMP-dependent synthetase and ligase
NIES970_10950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NIES970_10950	COG0723	plastoquinol--plastocyanin reductase activity
NIES970_10960	COG2264	protein methyltransferase activity
NIES970_10970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NIES970_10980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NIES970_10990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIES970_11010	COG0564	pseudouridine synthase activity
NIES970_11030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NIES970_11040	COG0539	negative regulation of cytoplasmic translation
NIES970_11060	COG0528	UMP kinase activity
NIES970_11070	COG0233	cytoplasmic translational termination
NIES970_11090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NIES970_11130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NIES970_11150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NIES970_11160	COG2310	stress, protein
NIES970_11170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIES970_11180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NIES970_11190	COG5001	Diguanylate cyclase
NIES970_11190	COG1716	ATPase activity
NIES970_11200	COG1702	phosphate starvation-inducible protein PhoH
NIES970_11210	COG0745	RESPONSE REGULATOR receiver
NIES970_11230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NIES970_11260	COG0363	glucosamine-6-phosphate deaminase activity
NIES970_11270	COG1716	ATPase activity
NIES970_11280	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NIES970_11290	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES970_11300	COG0839	Belongs to the complex I subunit 6 family
NIES970_11310	COG0713	ATP synthesis coupled electron transport
NIES970_11340	COG1104	cysteine desulfurase activity
NIES970_11350	COG4251	negative regulation of phosphorylation
NIES970_11360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NIES970_11440	COG1012	belongs to the aldehyde dehydrogenase family
NIES970_11450	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NIES970_11460	COG0602	queuosine metabolic process
NIES970_11470	COG0352	thiamine-phosphate diphosphorylase activity
NIES970_11550	COG2239	Acts as a magnesium transporter
NIES970_11560	COG0724	RNA recognition motif
NIES970_11570	COG1834	amidinotransferase
NIES970_11590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIES970_11630	COG0745	RESPONSE REGULATOR receiver
NIES970_11640	COG2203	Gaf domain
NIES970_11650	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NIES970_11660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NIES970_11690	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
NIES970_11720	COG0784	Response regulator, receiver
NIES970_11720	COG5002	protein histidine kinase activity
NIES970_11720	COG2198	Histidine kinase
NIES970_11730	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NIES970_11750	COG3266	domain, Protein
NIES970_11750	COG0515	serine threonine protein kinase
NIES970_11760	COG3842	ATPase activity
NIES970_11770	COG0799	negative regulation of ribosome biogenesis
NIES970_11810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NIES970_11820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NIES970_11850	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NIES970_11860	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NIES970_11870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NIES970_11890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NIES970_11910	COG0045	succinate-CoA ligase (ADP-forming) activity
NIES970_11940	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NIES970_11960	COG0456	acetyltransferase
NIES970_11970	COG2198	Histidine kinase
NIES970_11970	COG2205	protein histidine kinase activity
NIES970_11970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIES970_11970	COG0784	Response regulator, receiver
NIES970_11980	COG2048	Heterodisulfide reductase, subunit B
NIES970_12000	COG2161	toxin-antitoxin pair type II binding
NIES970_12030	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NIES970_12040	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NIES970_12050	COG0793	Belongs to the peptidase S41A family
NIES970_12070	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NIES970_12090	COG5001	Diguanylate cyclase
NIES970_12090	COG4251	negative regulation of phosphorylation
NIES970_12090	COG3706	GGDEF domain
NIES970_12090	COG2203	Gaf domain
NIES970_12150	COG2226	methyltransferase
NIES970_12180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NIES970_12190	COG0633	Ferredoxin
NIES970_12190	COG3217	Mosc domain protein beta barrel domain protein
NIES970_12200	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NIES970_12230	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NIES970_12250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NIES970_12280	COG0457	Tetratricopeptide repeat
NIES970_12280	COG0463	Glycosyl transferase, family 2
NIES970_12320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NIES970_12330	COG0788	formyltetrahydrofolate deformylase activity
NIES970_12340	COG0514	ATP-dependent DNA helicase (RecQ)
NIES970_12360	COG0025	NhaP-type Na H and K H
NIES970_12400	COG0003	Pfam Anion-transporting ATPase
NIES970_12410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES970_12430	COG0509	glycine decarboxylation via glycine cleavage system
NIES970_12450	COG0006	proline dipeptidase activity
NIES970_12460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NIES970_12470	COG0484	heat shock protein binding
NIES970_12520	COG0606	chelatase, subunit chli
NIES970_12540	COG1316	TRANSCRIPTIONal
NIES970_12560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIES970_12570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NIES970_12580	COG0157	Belongs to the NadC ModD family
NIES970_12600	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIES970_12630	COG2208	phosphoserine phosphatase activity
NIES970_12640	COG1216	Glycosyl transferase, family 2
NIES970_12650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NIES970_12670	COG2010	Cytochrome c
NIES970_12710	COG0513	Belongs to the DEAD box helicase family
NIES970_12720	COG0022	dehydrogenase e1 component
NIES970_12720	COG0508	dehydrogenase complex catalyzes the overall conversion of
NIES970_12730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NIES970_12740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NIES970_12760	COG2197	response regulator
NIES970_12780	COG0826	peptidase U32
NIES970_12810	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NIES970_12830	COG0740	serine-type endopeptidase activity
NIES970_12840	COG0740	serine-type endopeptidase activity
NIES970_12850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NIES970_12860	COG3118	belongs to the thioredoxin family
NIES970_12880	COG0583	DNA-binding transcription factor activity
NIES970_12900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NIES970_12930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIES970_12940	COG0436	Aminotransferase
NIES970_12970	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NIES970_13010	COG1253	flavin adenine dinucleotide binding
NIES970_13050	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NIES970_13070	COG0525	valine-tRNA ligase activity
NIES970_13090	COG0772	Belongs to the SEDS family
NIES970_13160	COG0805	protein transport
NIES970_13200	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NIES970_13230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES970_13290	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
NIES970_13370	COG0166	Belongs to the GPI family
NIES970_13410	COG0386	Belongs to the glutathione peroxidase family
NIES970_13440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NIES970_13450	COG0521	Mo-molybdopterin cofactor biosynthetic process
NIES970_13480	COG0850	regulation of cytokinetic process
NIES970_13490	COG2894	cell division
NIES970_13500	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NIES970_13520	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NIES970_13560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NIES970_13570	COG0612	Peptidase, M16
NIES970_13600	COG0434	BtpA family
NIES970_13610	COG4243	Vitamin k epoxide reductase
NIES970_13630	COG1215	transferase activity, transferring glycosyl groups
NIES970_13650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NIES970_13660	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NIES970_13670	COG2314	TM2 domain
NIES970_13690	COG0745	RESPONSE REGULATOR receiver
NIES970_13700	COG1126	abc transporter atp-binding protein
NIES970_13710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NIES970_13710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NIES970_13770	COG1450	Type ii and iii secretion system protein
NIES970_13780	COG0395	ABC-type sugar transport system, permease component
NIES970_13820	COG0653	protein targeting
NIES970_13840	COG5002	protein histidine kinase activity
NIES970_13840	COG2205	protein histidine kinase activity
NIES970_13840	COG0784	Response regulator, receiver
NIES970_13860	COG0592	DNA-directed DNA polymerase activity
NIES970_13920	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NIES970_13930	COG0632	four-way junction helicase activity
NIES970_13940	COG1372	Participates in initiation and elongation during chromosome replication
NIES970_13940	COG0305	Participates in initiation and elongation during chromosome replication
NIES970_13940	COG1372	Participates in initiation and elongation during chromosome replication
NIES970_13940	COG0305	Participates in initiation and elongation during chromosome replication
NIES970_13960	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NIES970_13970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIES970_13980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NIES970_13990	COG0544	peptidyl-prolyl cis-trans isomerase activity
NIES970_14060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NIES970_14070	COG0189	ligase activity
NIES970_14080	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NIES970_14100	COG2814	Major facilitator Superfamily
NIES970_14130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NIES970_14140	COG0385	Bile acid
NIES970_14170	COG0616	signal peptide processing
NIES970_14180	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NIES970_14250	COG3688	RNA-binding protein containing a PIN domain
NIES970_14260	COG2112	serine threonine protein kinase
NIES970_14290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NIES970_14310	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NIES970_14340	COG4399	Belongs to the UPF0754 family
NIES970_14350	COG0445	tRNA wobble uridine modification
NIES970_14370	COG4251	negative regulation of phosphorylation
NIES970_14380	COG3437	response regulator, receiver
NIES970_14390	COG0010	Belongs to the arginase family
NIES970_14400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIES970_14410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIES970_14430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NIES970_14450	COG2226	methyltransferase
NIES970_14460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NIES970_14490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NIES970_14490	COG0519	Catalyzes the synthesis of GMP from XMP
NIES970_14500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NIES970_14550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NIES970_14560	COG5001	Diguanylate cyclase
NIES970_14570	COG2205	protein histidine kinase activity
NIES970_14580	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NIES970_14590	COG0191	fructose-bisphosphate aldolase activity
NIES970_14610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NIES970_14660	COG0358	DNA primase activity
NIES970_14670	COG2046	Belongs to the sulfate adenylyltransferase family
NIES970_14680	COG0187	DNA topoisomerase II activity
NIES970_14680	COG1372	Participates in initiation and elongation during chromosome replication
NIES970_14810	COG1192	Involved in chromosome partitioning
NIES970_14840	COG0617	tRNA 3'-terminal CCA addition
NIES970_14860	COG1366	Belongs to the anti-sigma-factor antagonist family
NIES970_14870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NIES970_14890	COG0347	Belongs to the P(II) protein family
NIES970_14900	COG0824	Thioesterase
NIES970_14930	COG0156	8-amino-7-oxononanoate synthase activity
NIES970_14940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NIES970_14940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NIES970_14960	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NIES970_14970	COG0024	Methionine aminopeptidase
NIES970_15000	COG0561	phosphatase activity
NIES970_15010	COG1982	Orn Lys Arg decarboxylase major
NIES970_15020	COG0109	protoheme IX farnesyltransferase activity
NIES970_15030	COG1612	heme a metabolic process
NIES970_15040	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NIES970_15050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NIES970_15060	COG1845	cytochrome c oxidase, subunit III
NIES970_15120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NIES970_15130	COG0840	transmembrane signaling receptor activity
NIES970_15160	COG0745	RESPONSE REGULATOR receiver
NIES970_15190	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
NIES970_15220	COG1178	ABC-type Fe3 transport system permease component
NIES970_15230	COG5002	protein histidine kinase activity
NIES970_15230	COG2198	Histidine kinase
NIES970_15230	COG0784	Response regulator, receiver
NIES970_15260	COG5002	protein histidine kinase activity
NIES970_15310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NIES970_15320	COG2255	four-way junction helicase activity
NIES970_15360	COG1252	NADH dehydrogenase
NIES970_15380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NIES970_15440	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NIES970_15450	COG0248	Ppx GppA phosphatase
NIES970_15460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NIES970_15490	COG5002	protein histidine kinase activity
NIES970_15500	COG0151	Belongs to the GarS family
NIES970_15510	COG0392	lysyltransferase activity
NIES970_15560	COG1120	ATPase activity
NIES970_15570	COG0735	belongs to the Fur family
NIES970_15600	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NIES970_15610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NIES970_15620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES970_15630	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NIES970_15690	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
NIES970_15700	COG1252	NADH dehydrogenase
NIES970_15720	COG0829	nickel cation binding
NIES970_15730	COG0297	glycogen (starch) synthase activity
NIES970_15760	COG0418	dihydroorotase activity
NIES970_15780	COG0559	Belongs to the binding-protein-dependent transport system permease family
NIES970_15790	COG5002	protein histidine kinase activity
NIES970_15850	COG0674	pyruvate-flavodoxin oxidoreductase activity
NIES970_15850	COG1013	pyruvate-flavodoxin oxidoreductase activity
NIES970_15850	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NIES970_15850	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NIES970_15860	COG0167	dihydroorotate dehydrogenase activity
NIES970_15920	COG0587	DNA-directed DNA polymerase activity
NIES970_15960	COG0589	response to stress
NIES970_15970	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NIES970_15990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NIES970_16090	COG4636	protein conserved in cyanobacteria
NIES970_16100	COG0460	homoserine dehydrogenase
NIES970_16140	COG0439	Biotin carboxylase
NIES970_16150	COG1049	propionate catabolic process, 2-methylcitrate cycle
NIES970_16160	COG0515	serine threonine protein kinase
NIES970_16170	COG0116	Belongs to the methyltransferase superfamily
NIES970_16200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NIES970_16230	COG0517	IMP dehydrogenase activity
NIES970_16230	COG1994	Peptidase M50
NIES970_16250	COG0745	RESPONSE REGULATOR receiver
NIES970_16260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES970_16270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NIES970_16280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES970_16280	COG1116	anion transmembrane transporter activity
NIES970_16290	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
NIES970_16310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NIES970_16320	COG0784	Response regulator, receiver
NIES970_16340	COG4372	Transposase
NIES970_16360	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NIES970_16370	COG0275	rRNA processing
NIES970_16380	COG0582	viral genome integration into host DNA
NIES970_16390	COG0686	Belongs to the AlaDH PNT family
NIES970_16440	COG0463	Glycosyl transferase, family 2
NIES970_16450	COG0671	phosphoesterase, PA-phosphatase related
NIES970_16490	COG0612	Peptidase, M16
NIES970_16600	COG2205	protein histidine kinase activity
NIES970_16600	COG0784	Response regulator, receiver
NIES970_16610	COG3854	ATPases associated with a variety of cellular activities
NIES970_16660	COG0646	methionine synthase
NIES970_16660	COG1410	methionine synthase
NIES970_16690	COG2247	cell wall binding repeat
NIES970_16690	COG2385	sporulation resulting in formation of a cellular spore
NIES970_16700	COG0643	Histidine kinase
NIES970_16700	COG2198	Histidine kinase
NIES970_16710	COG0217	transcriptional regulatory protein
NIES970_16730	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NIES970_16750	COG0739	heme binding
NIES970_16760	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NIES970_16770	COG1045	serine acetyltransferase
NIES970_16780	COG1131	(ABC) transporter
NIES970_16790	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NIES970_16800	COG0210	DNA helicase
NIES970_16810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NIES970_16820	COG5002	protein histidine kinase activity
NIES970_16830	COG0745	RESPONSE REGULATOR receiver
NIES970_16860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NIES970_16890	COG3429	Glucose-6-phosphate dehydrogenase subunit
NIES970_16890	COG3409	Peptidoglycan-binding domain 1 protein
NIES970_16900	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NIES970_16910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NIES970_16940	COG2226	methyltransferase
NIES970_16950	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NIES970_16950	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NIES970_16990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NIES970_17000	COG0564	pseudouridine synthase activity
NIES970_17010	COG0484	heat shock protein binding
NIES970_17020	COG0443	Heat shock 70 kDa protein
NIES970_17040	COG4636	protein conserved in cyanobacteria
NIES970_17070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NIES970_17080	COG2133	pyrroloquinoline quinone binding
NIES970_17090	COG0163	prenyltransferase activity
NIES970_17110	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NIES970_17120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NIES970_17170	COG0504	CTP synthase activity
NIES970_17190	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NIES970_17200	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
NIES970_17220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NIES970_17230	COG3536	Protein conserved in bacteria
NIES970_17290	COG0681	Belongs to the peptidase S26 family
NIES970_17310	COG0442	prolyl-tRNA aminoacylation
NIES970_17320	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIES970_17330	COG0475	glutathione-regulated potassium exporter activity
NIES970_17330	COG0589	response to stress
NIES970_17340	COG0469	pyruvate kinase activity
NIES970_17410	COG0515	serine threonine protein kinase
NIES970_17460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NIES970_17470	COG0347	Belongs to the P(II) protein family
NIES970_17500	COG2226	methyltransferase
NIES970_17510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NIES970_17510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIES970_17570	COG0438	transferase activity, transferring glycosyl groups
NIES970_17580	COG0438	transferase activity, transferring glycosyl groups
NIES970_17660	COG1132	(ABC) transporter
NIES970_17700	COG0489	protein tyrosine kinase activity
NIES970_17710	COG1489	DNA binding
NIES970_17780	COG2814	Major facilitator Superfamily
NIES970_17810	COG4451	ribulose bisphosphate carboxylase, small
NIES970_17830	COG1850	ribulose-bisphosphate carboxylase activity
NIES970_17850	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NIES970_17850	COG4451	ribulose bisphosphate carboxylase, small
NIES970_17860	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
NIES970_17870	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NIES970_17880	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NIES970_17890	COG0659	secondary active sulfate transmembrane transporter activity
NIES970_17900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NIES970_17910	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES970_17930	COG1166	arginine decarboxylase activity
NIES970_17950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NIES970_17960	COG0719	Fe-S assembly protein
NIES970_17970	COG0396	ATPase activity
NIES970_17980	COG0719	Fe-S assembly protein
NIES970_18000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NIES970_18010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIES970_18050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NIES970_18070	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NIES970_18080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NIES970_18080	COG2022	thiamine diphosphate biosynthetic process
NIES970_18090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NIES970_18110	COG0408	coproporphyrinogen oxidase activity
NIES970_18120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NIES970_18130	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NIES970_18190	COG0633	Ferredoxin
NIES970_18250	COG1515	deoxyribonuclease V activity
NIES970_18270	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NIES970_18280	COG0745	RESPONSE REGULATOR receiver
NIES970_18300	COG0628	permease
NIES970_18320	COG1090	epimerase
NIES970_18350	COG2890	protein-(glutamine-N5) methyltransferase activity
NIES970_18400	COG0830	nickel cation binding
NIES970_18420	COG3300	MHYT domain
NIES970_18420	COG5001	Diguanylate cyclase
NIES970_18440	COG1473	amidohydrolase
NIES970_18450	COG1836	PFAM Integral membrane protein DUF92
NIES970_18460	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES970_18490	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NIES970_18530	COG0454	-acetyltransferase
NIES970_18560	COG1575	Belongs to the MenA family. Type 1 subfamily
NIES970_18570	COG1666	GTP binding
NIES970_18610	COG0156	8-amino-7-oxononanoate synthase activity
NIES970_18630	COG0318	PFAM AMP-dependent synthetase and ligase
NIES970_18650	COG2244	polysaccharide biosynthetic process
NIES970_18670	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES970_18710	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NIES970_18720	COG0390	transport system, permease component
NIES970_18740	COG0776	regulation of translation
NIES970_18750	COG0628	permease
NIES970_18760	COG2885	chlorophyll binding
NIES970_18770	COG2885	chlorophyll binding
NIES970_18780	COG0052	Belongs to the universal ribosomal protein uS2 family
NIES970_18790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NIES970_18800	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NIES970_18810	COG2197	response regulator
NIES970_18840	COG2205	protein histidine kinase activity
NIES970_18850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NIES970_18890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIES970_18900	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
NIES970_18950	COG0023	Translation Initiation Factor
NIES970_18960	COG0515	serine threonine protein kinase
NIES970_18970	COG0395	ABC-type sugar transport system, permease component
NIES970_18980	COG1175	transmembrane transport
NIES970_18990	COG1653	transport
NIES970_19000	COG3842	ATPase activity
NIES970_19010	COG1027	Aspartate ammonia-lyase
NIES970_19030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIES970_19040	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NIES970_19050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NIES970_19080	COG0668	transmembrane transport
NIES970_19090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NIES970_19090	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NIES970_19100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NIES970_19130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NIES970_19140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NIES970_19160	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NIES970_19210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NIES970_19230	COG0514	ATP-dependent DNA helicase (RecQ)
NIES970_19240	COG3932	Exopolysaccharide synthesis, ExoD
NIES970_19260	COG0326	Molecular chaperone. Has ATPase activity
NIES970_19280	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NIES970_19290	COG0772	Belongs to the SEDS family
NIES970_19320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIES970_19350	COG1132	(ABC) transporter
NIES970_19360	COG0436	Aminotransferase
NIES970_19380	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NIES970_19390	COG0003	Pfam Anion-transporting ATPase
NIES970_19400	COG2268	Band 7 protein
NIES970_19420	COG5398	heme oxygenase
NIES970_19440	COG1840	ABC-type Fe3 transport system, periplasmic component
NIES970_19450	COG0758	DNA mediated transformation
NIES970_19450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NIES970_19460	COG0505	Belongs to the CarA family
NIES970_19470	COG5002	protein histidine kinase activity
NIES970_19480	COG0596	Alpha beta hydrolase
NIES970_19490	COG2217	Heavy metal translocating P-type atpase
NIES970_19500	COG2132	Multicopper oxidase
NIES970_19520	COG3063	Type IV pilus biogenesis stability protein PilW
NIES970_19530	COG0589	response to stress
NIES970_19540	COG0126	phosphoglycerate kinase activity
NIES970_19580	COG1181	Belongs to the D-alanine--D-alanine ligase family
NIES970_19590	COG0247	lactate metabolic process
NIES970_19640	COG0529	Catalyzes the synthesis of activated sulfate
NIES970_19660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NIES970_19750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NIES970_19770	COG0667	Aldo Keto reductase
NIES970_19790	COG2843	Capsule synthesis protein
NIES970_19850	COG2319	Wd-40 repeat
NIES970_19850	COG4249	Peptidase C14 caspase catalytic subunit p20
NIES970_19910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NIES970_19920	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES970_19930	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES970_19940	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES970_19970	COG3266	domain, Protein
NIES970_19970	COG0515	serine threonine protein kinase
NIES970_20000	COG0583	DNA-binding transcription factor activity
NIES970_20040	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NIES970_20060	COG1803	Methylglyoxal synthase
NIES970_20060	COG1597	lipid kinase activity
NIES970_20140	COG2062	phosphohistidine phosphatase, SixA
NIES970_20150	COG0372	Belongs to the citrate synthase family
NIES970_20170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NIES970_20210	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NIES970_20220	COG2385	sporulation resulting in formation of a cellular spore
NIES970_20230	COG1295	ribonuclease BN
NIES970_20270	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
NIES970_20280	COG0009	L-threonylcarbamoyladenylate synthase
NIES970_20290	COG0704	Plays a role in the regulation of phosphate uptake
NIES970_20300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NIES970_20310	COG0328	RNA-DNA hybrid ribonuclease activity
NIES970_20330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NIES970_20340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NIES970_20350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NIES970_20360	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NIES970_20370	COG0085	RNA polymerase activity
NIES970_20380	COG0084	hydrolase, TatD family'
NIES970_20390	COG0268	Binds directly to 16S ribosomal RNA
NIES970_20490	COG1160	GTP binding
NIES970_20510	COG0051	transcription antitermination factor activity, RNA binding
NIES970_20520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NIES970_20530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NIES970_20540	COG0049	tRNA binding
NIES970_20550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NIES970_20560	COG0316	Belongs to the HesB IscA family
NIES970_20580	COG0590	tRNA wobble adenosine to inosine editing
NIES970_20590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NIES970_20600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NIES970_20620	COG0210	DNA helicase
NIES970_20640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NIES970_20650	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NIES970_20680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NIES970_20730	COG0612	Peptidase, M16
NIES970_20740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIES970_20750	COG3258	Cytochrome c
NIES970_20760	COG0723	plastoquinol--plastocyanin reductase activity
NIES970_20820	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NIES970_20830	COG5001	Diguanylate cyclase
NIES970_20830	COG1716	ATPase activity
NIES970_20840	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NIES970_20860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIES970_20870	COG0861	Integral membrane protein TerC family
NIES970_20890	COG2045	Belongs to the ComB family
NIES970_20910	COG2363	Small membrane protein
NIES970_20920	COG0312	modulator of DNA gyrase
NIES970_20930	COG0747	negative chemotaxis
NIES970_20960	COG0366	Alpha amylase catalytic
NIES970_20970	COG3769	mannosylglycerate metabolic process
NIES970_21030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NIES970_21040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIES970_21060	COG1598	PFAM Uncharacterised protein family UPF0150
NIES970_21070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NIES970_21090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES970_21110	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NIES970_21120	COG0406	alpha-ribazole phosphatase activity
NIES970_21130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NIES970_21150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NIES970_21160	COG2211	Major facilitator Superfamily
NIES970_21210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIES970_21230	COG0601	transmembrane transport
NIES970_21240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NIES970_21270	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NIES970_21280	COG0569	domain protein
NIES970_21290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NIES970_21320	COG4999	Histidine kinase
NIES970_21320	COG2205	protein histidine kinase activity
NIES970_21320	COG3437	response regulator, receiver
NIES970_21320	COG3850	Histidine kinase
NIES970_21360	COG0124	histidyl-tRNA synthetase
NIES970_21380	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NIES970_21400	COG2267	carboxylic ester hydrolase activity
NIES970_21410	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NIES970_21430	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NIES970_21440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NIES970_21450	COG0581	inorganic phosphate transmembrane transporter activity
NIES970_21470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIES970_21500	COG0802	atpase or kinase
NIES970_21530	COG0315	cyclic pyranopterin monophosphate synthase activity
NIES970_21550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NIES970_21560	COG3152	Membrane
NIES970_21600	COG3046	protein related to deoxyribodipyrimidine photolyase
NIES970_21620	COG0768	penicillin binding
NIES970_21660	COG1595	DNA-templated transcription, initiation
NIES970_21690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIES970_21740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NIES970_21750	COG0314	molybdopterin synthase activity
NIES970_21780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NIES970_21820	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NIES970_21870	COG2205	protein histidine kinase activity
NIES970_21900	COG1215	transferase activity, transferring glycosyl groups
NIES970_21910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NIES970_21920	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NIES970_21930	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NIES970_21950	COG2217	Heavy metal translocating P-type atpase
NIES970_22020	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES970_22040	COG1420	regulation of RNA biosynthetic process
NIES970_22080	COG0237	dephospho-CoA kinase activity
NIES970_22080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NIES970_22090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NIES970_22100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIES970_22150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIES970_22170	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NIES970_22180	COG1799	cell septum assembly
NIES970_22190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NIES970_22200	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NIES970_22210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NIES970_22230	COG0037	tRNA processing
NIES970_22250	COG0484	heat shock protein binding
NIES970_22330	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NIES970_22330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIES970_22340	COG1562	ergosterol biosynthetic process
NIES970_22350	COG0745	RESPONSE REGULATOR receiver
NIES970_22360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NIES970_22410	COG0175	sulfate reduction
NIES970_22420	COG0359	binds to the 23S rRNA
NIES970_22430	COG0517	IMP dehydrogenase activity
NIES970_22440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NIES970_22460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NIES970_22530	COG4636	protein conserved in cyanobacteria
NIES970_22550	COG0297	glycogen (starch) synthase activity
NIES970_22570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NIES970_22580	COG0740	serine-type endopeptidase activity
NIES970_22660	COG0557	exoribonuclease II activity
NIES970_22690	COG0047	phosphoribosylformylglycinamidine synthase activity
NIES970_22700	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NIES970_22710	COG0701	Predicted permease
NIES970_22730	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NIES970_22730	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NIES970_22740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIES970_22750	COG1131	(ABC) transporter
NIES970_22770	COG0842	Transport permease protein
NIES970_22780	COG0745	RESPONSE REGULATOR receiver
NIES970_22820	COG1316	TRANSCRIPTIONal
NIES970_22890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NIES970_22940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NIES970_22950	COG0793	Belongs to the peptidase S41A family
NIES970_22970	COG2052	Domain of unknown function (DUF370)
NIES970_22980	COG0194	GDP metabolic process
NIES970_22990	COG0740	serine-type endopeptidase activity
NIES970_23000	COG2226	methyltransferase
NIES970_23010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NIES970_23030	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
NIES970_23070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NIES970_23090	COG1116	anion transmembrane transporter activity
NIES970_23100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES970_23100	COG1116	anion transmembrane transporter activity
NIES970_23110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NIES970_23120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES970_23160	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NIES970_23170	COG0640	Transcriptional regulator
NIES970_23200	COG2124	cytochrome p450
NIES970_23220	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NIES970_23240	COG0495	leucyl-tRNA aminoacylation
NIES970_23270	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NIES970_23280	COG2310	stress, protein
NIES970_23300	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NIES970_23340	COG1082	Xylose isomerase domain protein TIM barrel
NIES970_23350	COG0596	Alpha beta hydrolase
NIES970_23360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NIES970_23400	COG0683	leucine binding
NIES970_23450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NIES970_23470	COG0004	ammonium transporteR
NIES970_23500	COG0237	dephospho-CoA kinase activity
NIES970_23510	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NIES970_23520	COG1413	lyase activity
NIES970_23530	COG1413	lyase activity
NIES970_23550	COG0824	Thioesterase
NIES970_23570	COG0537	adenosine 5'-monophosphoramidase activity
NIES970_23630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NIES970_23640	COG1131	(ABC) transporter
NIES970_23670	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NIES970_23710	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NIES970_23720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIES970_23740	COG0792	nuclease activity
NIES970_23760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NIES970_23780	COG2304	oxidoreductase activity
NIES970_23790	COG2501	S4 domain
NIES970_23800	COG0412	Dienelactone hydrolase
NIES970_23820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NIES970_23830	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NIES970_23870	COG0552	protein localization to endoplasmic reticulum
NIES970_23880	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NIES970_23890	COG0415	Belongs to the DNA photolyase family
NIES970_23960	COG4968	Prepilin-type N-terminal cleavage methylation domain
NIES970_23970	COG2852	Protein conserved in bacteria
NIES970_23980	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES970_23990	COG0004	ammonium transporteR
NIES970_24020	COG2319	Wd-40 repeat
NIES970_24060	COG1741	Belongs to the pirin family
NIES970_24080	COG0237	dephospho-CoA kinase activity
NIES970_24090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NIES970_24110	COG0237	dephospho-CoA kinase activity
NIES970_24130	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NIES970_24140	COG0482	sulfurtransferase activity
NIES970_24170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NIES970_24190	COG0440	acetolactate synthase activity
NIES970_24200	COG2267	carboxylic ester hydrolase activity
NIES970_24210	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NIES970_24260	COG0330	HflC and HflK could
NIES970_24270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIES970_24290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NIES970_24300	COG1672	PFAM Archaeal ATPase
NIES970_24310	COG0589	response to stress
NIES970_24340	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NIES970_24360	COG1252	NADH dehydrogenase
NIES970_24370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NIES970_24390	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NIES970_24400	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NIES970_24410	COG0481	GTPase activity
NIES970_24440	COG0443	Heat shock 70 kDa protein
NIES970_24450	COG1064	alcohol dehydrogenase
NIES970_24470	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NIES970_24500	COG0435	Glutathione S-transferase
NIES970_24530	COG1480	7TM receptor with intracellular HD hydrolase
NIES970_24590	COG1605	Chorismate mutase
NIES970_24590	COG0077	Prephenate dehydratase
NIES970_24610	COG1473	amidohydrolase
NIES970_24640	COG0714	Associated with various cellular activities
NIES970_24650	COG0196	riboflavin kinase activity
NIES970_24660	COG1234	tRNA 3'-trailer cleavage
NIES970_24690	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NIES970_24740	COG0069	glutamate synthase activity
NIES970_24740	COG0070	glutamate synthase
NIES970_24740	COG0067	glutamate synthase
NIES970_24760	COG2010	Cytochrome c
NIES970_24810	COG1187	pseudouridine synthase activity
NIES970_24830	COG0587	DNA-directed DNA polymerase activity
NIES970_24840	COG1056	cytidyltransferase-related domain
NIES970_24840	COG1051	belongs to the nudix hydrolase family
NIES970_24850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NIES970_24920	COG0651	ATP synthesis coupled electron transport
NIES970_24940	COG0475	glutathione-regulated potassium exporter activity
NIES970_24950	COG0659	secondary active sulfate transmembrane transporter activity
NIES970_24960	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NIES970_24970	COG3174	membrane
NIES970_24990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES970_25000	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NIES970_25020	COG0415	Belongs to the DNA photolyase family
NIES970_25040	COG0572	uridine kinase
NIES970_25050	COG2193	ferroxidase activity
NIES970_25100	COG0523	cobalamin synthesis protein
NIES970_25110	COG2200	EAL domain
NIES970_25120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NIES970_25160	COG0683	leucine binding
NIES970_25170	COG0709	Synthesizes selenophosphate from selenide and ATP
NIES970_25180	COG0784	Response regulator, receiver
NIES970_25180	COG2205	protein histidine kinase activity
NIES970_25190	COG0745	RESPONSE REGULATOR receiver
NIES970_25210	COG3012	SEC-C Motif Domain Protein
NIES970_25240	COG2226	methyltransferase
NIES970_25250	COG0668	transmembrane transport
NIES970_25270	COG0174	glutamine synthetase
NIES970_25280	COG0724	RNA recognition motif
NIES970_25290	COG0123	including yeast histone deacetylase and acetoin utilization protein
NIES970_25310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NIES970_25330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NIES970_25340	COG2346	COG2346, Truncated hemoglobins
NIES970_25350	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NIES970_25390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NIES970_25410	COG3118	belongs to the thioredoxin family
NIES970_25460	COG0181	hydroxymethylbilane synthase activity
NIES970_25470	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NIES970_25480	COG0730	response to heat
NIES970_25490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NIES970_25500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIES970_25510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NIES970_25520	COG5001	Diguanylate cyclase
NIES970_25520	COG2203	Gaf domain
NIES970_25520	COG3706	GGDEF domain
NIES970_25520	COG4251	negative regulation of phosphorylation
NIES970_25550	COG0277	FAD linked oxidase domain protein
NIES970_25560	COG3954	Phosphoribulokinase
NIES970_25580	COG0746	molybdenum cofactor guanylyltransferase activity
NIES970_25590	COG0135	phosphoribosylanthranilate isomerase activity
NIES970_25600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NIES970_25610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NIES970_25620	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NIES970_25650	COG2211	Major facilitator Superfamily
NIES970_25660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NIES970_25690	COG0484	heat shock protein binding
NIES970_25780	COG4251	negative regulation of phosphorylation
NIES970_25860	COG2010	Cytochrome c
NIES970_25870	COG1131	(ABC) transporter
NIES970_25880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NIES970_25930	COG0131	Imidazoleglycerol-phosphate dehydratase
NIES970_25940	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NIES970_25960	COG0745	RESPONSE REGULATOR receiver
NIES970_25980	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NIES970_25990	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NIES970_26010	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NIES970_26030	COG1546	Belongs to the CinA family
NIES970_26030	COG1058	Belongs to the CinA family
NIES970_26050	COG0745	RESPONSE REGULATOR receiver
NIES970_26060	COG3411	Ferredoxin
NIES970_26090	COG0300	oxidoreductase activity
NIES970_26090	COG3000	fatty acid hydroxylase
NIES970_26110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NIES970_26120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NIES970_26160	COG2770	Histidine kinase
NIES970_26160	COG2208	phosphoserine phosphatase activity
NIES970_26170	COG0745	RESPONSE REGULATOR receiver
NIES970_26170	COG3706	GGDEF domain
NIES970_26190	COG1366	Belongs to the anti-sigma-factor antagonist family
NIES970_26210	COG1366	Belongs to the anti-sigma-factor antagonist family
NIES970_26280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NIES970_26290	COG0768	penicillin binding
NIES970_26320	COG2304	oxidoreductase activity
NIES970_26330	COG0215	cysteine-tRNA ligase activity
NIES970_26350	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NIES970_26360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NIES970_26390	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NIES970_26400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NIES970_26410	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
NIES970_26410	COG0662	Cupin 2, conserved barrel domain protein
NIES970_26440	COG1830	Aldolase
NIES970_26510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES970_26520	COG0742	ribosomal rna small subunit methyltransferase
NIES970_26550	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NIES970_26560	COG0351	phosphomethylpyrimidine kinase
NIES970_26570	COG1160	GTP binding
NIES970_26580	COG0572	uridine kinase
NIES970_26610	COG0783	Belongs to the Dps family
NIES970_26650	COG0745	RESPONSE REGULATOR receiver
NIES970_26660	COG0745	RESPONSE REGULATOR receiver
NIES970_26670	COG0784	Response regulator, receiver
NIES970_26690	COG1218	3'(2'),5'-bisphosphate nucleotidase
NIES970_26700	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NIES970_26720	COG0180	Tryptophanyl-tRNA synthetase
NIES970_26750	COG0384	phenazine biosynthesis protein PhzF
NIES970_26760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES970_26810	COG0784	Response regulator, receiver
NIES970_26840	COG2203	Gaf domain
NIES970_26840	COG0840	transmembrane signaling receptor activity
NIES970_26850	COG2198	Histidine kinase
NIES970_26850	COG0643	Histidine kinase
NIES970_26880	COG0511	ligase activity, forming carbon-carbon bonds
NIES970_26890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NIES970_26900	COG1040	competence protein
NIES970_26940	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NIES970_26960	COG0494	nUDIX hydrolase
NIES970_26970	COG0571	ribonuclease III activity
NIES970_27000	COG0737	Belongs to the 5'-nucleotidase family
NIES970_27020	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NIES970_27030	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NIES970_27060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NIES970_27070	COG0137	argininosuccinate synthase activity
NIES970_27080	COG3239	Fatty acid desaturase
NIES970_27100	COG2119	membrane
NIES970_27120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NIES970_27140	COG1012	belongs to the aldehyde dehydrogenase family
NIES970_27160	COG0625	glutathione transferase activity
NIES970_27180	COG0343	queuine tRNA-ribosyltransferase activity
NIES970_27200	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NIES970_27280	COG0725	ABC transporter, periplasmic molybdate-binding protein
NIES970_27290	COG3842	ATPase activity
NIES970_27300	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NIES970_27310	COG1086	Polysaccharide biosynthesis protein
NIES970_27320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NIES970_27330	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
NIES970_27380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NIES970_27390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NIES970_27400	COG2089	acid synthase
NIES970_27410	COG1132	(ABC) transporter
NIES970_27440	COG1132	(ABC) transporter
NIES970_27500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NIES970_27510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NIES970_27540	COG1132	(ABC) transporter
NIES970_27560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NIES970_27590	COG1132	(ABC) transporter
NIES970_27600	COG0848	biopolymer transport protein
NIES970_27610	COG0811	peptide transport
NIES970_27630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NIES970_27750	COG0515	serine threonine protein kinase
NIES970_27800	COG0398	Pfam SNARE associated Golgi protein
NIES970_27860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NIES970_27940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NIES970_27950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES970_27950	COG1116	anion transmembrane transporter activity
NIES970_27960	COG1116	anion transmembrane transporter activity
NIES970_27980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIES970_28000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NIES970_28030	COG2226	methyltransferase
NIES970_28040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIES970_28120	COG0076	glutamate decarboxylase activity
NIES970_28140	COG0113	porphobilinogen synthase activity
NIES970_28150	COG0302	gtp cyclohydrolase
NIES970_28200	COG3384	dioxygenase
NIES970_28240	COG2885	chlorophyll binding
NIES970_28300	COG0398	Pfam SNARE associated Golgi protein
NIES970_28340	COG5002	protein histidine kinase activity
NIES970_28350	COG0745	RESPONSE REGULATOR receiver
NIES970_28370	COG1131	(ABC) transporter
NIES970_28380	COG0842	Transport permease protein
NIES970_28390	COG3268	Saccharopine dehydrogenase
NIES970_28400	COG1253	flavin adenine dinucleotide binding
NIES970_28530	COG3903	Transcriptional regulator
NIES970_28530	COG2319	Wd-40 repeat
NIES970_28540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NIES970_28590	COG0024	Methionine aminopeptidase
NIES970_28600	COG4221	oxidoreductase activity
NIES970_28740	COG2144	transferase activity, transferring acyl groups
NIES970_28790	COG2072	flavoprotein involved in K transport
NIES970_28800	COG2197	response regulator
NIES970_28860	COG5002	protein histidine kinase activity
NIES970_28920	COG2132	Multicopper oxidase
NIES970_28950	COG2205	protein histidine kinase activity
NIES970_28960	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NIES970_28980	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NIES970_28990	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NIES970_29000	COG5002	protein histidine kinase activity
NIES970_29010	COG2197	response regulator
NIES970_29080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NIES970_29260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NIES970_29460	COG1104	cysteine desulfurase activity
NIES970_29510	COG1074	ATP-dependent DNA helicase activity
NIES970_29560	COG1192	Involved in chromosome partitioning
NIES970_29570	COG1475	DNA binding
NIES970_29590	COG2442	InterPro IPR007367
NIES970_29600	COG3093	addiction module antidote protein HigA
NIES970_29650	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NIES970_29680	COG2378	regulation of single-species biofilm formation
NIES970_29710	COG1203	CRISPR-associated helicase, Cas3
NIES970_29730	COG1857	crispr-associated protein
NIES970_29790	COG1468	defense response to virus
NIES970_29790	COG1518	maintenance of DNA repeat elements
NIES970_29800	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NIES970_29980	COG1061	Type III restriction enzyme res subunit
NIES970_30070	COG1192	Involved in chromosome partitioning
NIES970_30090	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity