locus-tag	class	description
Syn6312_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Syn6312_0002	COG0450	alkyl hydroperoxide reductase
Syn6312_0003	COG0343	queuine tRNA-ribosyltransferase activity
Syn6312_0004	COG4372	Transposase
Syn6312_0006	COG0750	zinc metalloprotease
Syn6312_0010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Syn6312_0011	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
Syn6312_0022	COG0004	ammonium transporteR
Syn6312_0023	COG4581	dead DEAH box helicase
Syn6312_0025	COG0840	transmembrane signaling receptor activity
Syn6312_0027	COG0745	RESPONSE REGULATOR receiver
Syn6312_0031	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Syn6312_0035	COG0515	serine threonine protein kinase
Syn6312_0037	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Syn6312_0039	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Syn6312_0042	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Syn6312_0046	COG0457	Tetratricopeptide repeat
Syn6312_0047	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Syn6312_0049	COG0745	RESPONSE REGULATOR receiver
Syn6312_0050	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Syn6312_0051	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Syn6312_0053	COG0275	rRNA processing
Syn6312_0056	COG0589	response to stress
Syn6312_0056	COG0475	glutathione-regulated potassium exporter activity
Syn6312_0060	COG0121	glutamine amidotransferase
Syn6312_0063	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Syn6312_0065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Syn6312_0065	COG2205	protein histidine kinase activity
Syn6312_0072	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Syn6312_0073	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Syn6312_0074	COG3237	CsbD-like
Syn6312_0076	COG3237	CsbD-like
Syn6312_0081	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Syn6312_0081	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Syn6312_0083	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Syn6312_0084	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
Syn6312_0092	COG0411	ABC transporter
Syn6312_0094	COG0270	DNA (cytosine-5-)-methyltransferase activity
Syn6312_0096	COG1836	PFAM Integral membrane protein DUF92
Syn6312_0097	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Syn6312_0097	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Syn6312_0100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Syn6312_0108	COG3852	Histidine kinase
Syn6312_0109	COG0745	RESPONSE REGULATOR receiver
Syn6312_0117	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Syn6312_0118	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Syn6312_0119	COG1122	ATPase activity
Syn6312_0121	COG0596	Alpha beta hydrolase
Syn6312_0122	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Syn6312_0123	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Syn6312_0124	COG0022	dehydrogenase e1 component
Syn6312_0124	COG0508	dehydrogenase complex catalyzes the overall conversion of
Syn6312_0127	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Syn6312_0130	COG1834	amidinotransferase
Syn6312_0131	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Syn6312_0132	COG0772	Belongs to the SEDS family
Syn6312_0133	COG3300	MHYT domain
Syn6312_0133	COG5001	Diguanylate cyclase
Syn6312_0134	COG5002	protein histidine kinase activity
Syn6312_0136	COG0310	cobalt ion transport
Syn6312_0138	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
Syn6312_0141	COG2022	thiamine diphosphate biosynthetic process
Syn6312_0141	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Syn6312_0142	COG0589	response to stress
Syn6312_0148	COG2304	oxidoreductase activity
Syn6312_0150	COG0484	heat shock protein binding
Syn6312_0154	COG0488	(ABC) transporter
Syn6312_0156	COG0352	thiamine-phosphate diphosphorylase activity
Syn6312_0158	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Syn6312_0160	COG4636	protein conserved in cyanobacteria
Syn6312_0161	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
Syn6312_0162	COG0028	Belongs to the TPP enzyme family
Syn6312_0165	COG0170	dolichyl monophosphate biosynthetic process
Syn6312_0168	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Syn6312_0169	COG1372	Participates in initiation and elongation during chromosome replication
Syn6312_0169	COG0187	DNA topoisomerase II activity
Syn6312_0178	COG0395	ABC-type sugar transport system, permease component
Syn6312_0179	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Syn6312_0181	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Syn6312_0182	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Syn6312_0183	COG0166	Belongs to the GPI family
Syn6312_0186	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Syn6312_0186	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Syn6312_0191	COG0537	adenosine 5'-monophosphoramidase activity
Syn6312_0198	COG1333	cytochrome c biogenesis protein
Syn6312_0203	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Syn6312_0205	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Syn6312_0218	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Syn6312_0218	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Syn6312_0220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Syn6312_0223	COG1090	epimerase
Syn6312_0225	COG1840	ABC-type Fe3 transport system, periplasmic component
Syn6312_0227	COG3264	Mechanosensitive ion channel
Syn6312_0227	COG1511	domain protein
Syn6312_0228	COG1012	belongs to the aldehyde dehydrogenase family
Syn6312_0231	COG0415	Belongs to the DNA photolyase family
Syn6312_0233	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Syn6312_0237	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Syn6312_0241	COG4636	protein conserved in cyanobacteria
Syn6312_0245	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Syn6312_0246	COG0330	HflC and HflK could
Syn6312_0247	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Syn6312_0247	COG0758	DNA mediated transformation
Syn6312_0251	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Syn6312_0253	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Syn6312_0253	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Syn6312_0256	COG0217	transcriptional regulatory protein
Syn6312_0260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Syn6312_0263	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Syn6312_0264	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Syn6312_0265	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Syn6312_0266	COG1252	NADH dehydrogenase
Syn6312_0269	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Syn6312_0274	COG4251	negative regulation of phosphorylation
Syn6312_0275	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Syn6312_0279	COG0793	Belongs to the peptidase S41A family
Syn6312_0280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Syn6312_0282	COG1620	l-lactate permease
Syn6312_0286	COG0656	L-ascorbic acid biosynthetic process
Syn6312_0289	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Syn6312_0290	COG2119	membrane
Syn6312_0291	COG0443	Heat shock 70 kDa protein
Syn6312_0297	COG1136	(ABC) transporter
Syn6312_0301	COG0463	Glycosyl transferase, family 2
Syn6312_0305	COG0848	biopolymer transport protein
Syn6312_0306	COG0811	peptide transport
Syn6312_0308	COG3659	wide pore channel activity
Syn6312_0309	COG0251	oxidation-reduction process
Syn6312_0315	COG4636	protein conserved in cyanobacteria
Syn6312_0318	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Syn6312_0323	COG0484	heat shock protein binding
Syn6312_0328	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
Syn6312_0332	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Syn6312_0334	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Syn6312_0336	COG0714	Associated with various cellular activities
Syn6312_0339	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Syn6312_0340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Syn6312_0343	COG0121	glutamine amidotransferase
Syn6312_0344	COG1446	asparaginase
Syn6312_0346	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Syn6312_0350	COG3854	ATPases associated with a variety of cellular activities
Syn6312_0353	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Syn6312_0354	COG0633	Ferredoxin
Syn6312_0357	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Syn6312_0366	COG1253	flavin adenine dinucleotide binding
Syn6312_0367	COG0434	BtpA family
Syn6312_0368	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Syn6312_0369	COG0590	tRNA wobble adenosine to inosine editing
Syn6312_0370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Syn6312_0372	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Syn6312_0373	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Syn6312_0376	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Syn6312_0377	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Syn6312_0381	COG4106	trans-aconitate 2-methyltransferase activity
Syn6312_0382	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Syn6312_0385	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Syn6312_0389	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Syn6312_0397	COG0515	serine threonine protein kinase
Syn6312_0397	COG1357	PFAM Pentapeptide repeats (8 copies)
Syn6312_0398	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Syn6312_0400	COG2814	Major facilitator Superfamily
Syn6312_0402	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Syn6312_0403	COG0860	N-Acetylmuramoyl-L-alanine amidase
Syn6312_0404	COG0277	FAD linked oxidase domain protein
Syn6312_0405	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Syn6312_0412	COG0497	DNA recombination
Syn6312_0415	COG1160	GTP binding
Syn6312_0427	COG0165	Argininosuccinate lyase
Syn6312_0431	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Syn6312_0437	COG0047	phosphoribosylformylglycinamidine synthase activity
Syn6312_0439	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Syn6312_0441	COG0596	Alpha beta hydrolase
Syn6312_0446	COG0745	RESPONSE REGULATOR receiver
Syn6312_0447	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Syn6312_0450	COG0739	heme binding
Syn6312_0451	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Syn6312_0458	COG1598	PFAM Uncharacterised protein family UPF0150
Syn6312_0459	COG0509	glycine decarboxylation via glycine cleavage system
Syn6312_0460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Syn6312_0462	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Syn6312_0464	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Syn6312_0465	COG2197	response regulator
Syn6312_0466	COG2203	Gaf domain
Syn6312_0466	COG3706	GGDEF domain
Syn6312_0466	COG4251	negative regulation of phosphorylation
Syn6312_0466	COG5001	Diguanylate cyclase
Syn6312_0467	COG0726	polysaccharide deacetylase
Syn6312_0471	COG0445	tRNA wobble uridine modification
Syn6312_0477	COG0765	amino acid transport
Syn6312_0482	COG0196	riboflavin kinase activity
Syn6312_0483	COG0612	Peptidase, M16
Syn6312_0490	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Syn6312_0491	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Syn6312_0492	COG4208	sulfate ABC transporter
Syn6312_0493	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Syn6312_0497	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
Syn6312_0498	COG0617	tRNA 3'-terminal CCA addition
Syn6312_0499	COG0552	protein localization to endoplasmic reticulum
Syn6312_0500	COG0515	serine threonine protein kinase
Syn6312_0500	COG4991	sh3 domain protein
Syn6312_0500	COG3064	Membrane
Syn6312_0501	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Syn6312_0502	COG1126	abc transporter atp-binding protein
Syn6312_0504	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Syn6312_0505	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Syn6312_0510	COG4636	protein conserved in cyanobacteria
Syn6312_0515	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Syn6312_0517	COG2094	Belongs to the DNA glycosylase MPG family
Syn6312_0519	COG1116	anion transmembrane transporter activity
Syn6312_0520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Syn6312_0526	COG0540	Belongs to the ATCase OTCase family
Syn6312_0528	COG3937	granule-associated protein
Syn6312_0530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Syn6312_0531	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Syn6312_0532	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Syn6312_0538	COG0109	protoheme IX farnesyltransferase activity
Syn6312_0541	COG2217	Heavy metal translocating P-type atpase
Syn6312_0545	COG0284	orotidine-5'-phosphate decarboxylase activity
Syn6312_0546	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Syn6312_0549	COG0484	heat shock protein binding
Syn6312_0553	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Syn6312_0555	COG0484	heat shock protein binding
Syn6312_0557	COG1162	GTPase activity
Syn6312_0559	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Syn6312_0563	COG0860	N-Acetylmuramoyl-L-alanine amidase
Syn6312_0564	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Syn6312_0565	COG3063	Type IV pilus biogenesis stability protein PilW
Syn6312_0567	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Syn6312_0569	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Syn6312_0570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Syn6312_0571	COG0557	exoribonuclease II activity
Syn6312_0572	COG0629	single-stranded DNA binding
Syn6312_0573	COG4243	Vitamin k epoxide reductase
Syn6312_0574	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Syn6312_0577	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Syn6312_0580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Syn6312_0581	COG0640	Transcriptional regulator
Syn6312_0583	COG0602	queuosine metabolic process
Syn6312_0585	COG0205	6-phosphofructokinase activity
Syn6312_0586	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Syn6312_0589	COG2267	carboxylic ester hydrolase activity
Syn6312_0590	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Syn6312_0592	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Syn6312_0593	COG2843	Capsule synthesis protein
Syn6312_0596	COG0133	tryptophan synthase activity
Syn6312_0601	COG0739	heme binding
Syn6312_0602	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Syn6312_0603	COG0463	Glycosyl transferase, family 2
Syn6312_0603	COG0457	Tetratricopeptide repeat
Syn6312_0605	COG0191	fructose-bisphosphate aldolase activity
Syn6312_0606	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Syn6312_0607	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Syn6312_0609	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Syn6312_0610	COG2385	sporulation resulting in formation of a cellular spore
Syn6312_0612	COG0473	3-isopropylmalate dehydrogenase activity
Syn6312_0614	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Syn6312_0616	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Syn6312_0617	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Syn6312_0618	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Syn6312_0624	COG0459	protein refolding
Syn6312_0625	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Syn6312_0627	COG0779	Required for maturation of 30S ribosomal subunits
Syn6312_0628	COG0195	Participates in both transcription termination and antitermination
Syn6312_0630	COG0714	Associated with various cellular activities
Syn6312_0631	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Syn6312_0634	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Syn6312_0638	COG0824	Thioesterase
Syn6312_0641	COG1741	Belongs to the pirin family
Syn6312_0643	COG1733	regulation of RNA biosynthetic process
Syn6312_0645	COG1012	belongs to the aldehyde dehydrogenase family
Syn6312_0646	COG0612	Peptidase, M16
Syn6312_0650	COG0004	ammonium transporteR
Syn6312_0655	COG0667	Aldo Keto reductase
Syn6312_0657	COG0592	DNA-directed DNA polymerase activity
Syn6312_0659	COG0583	DNA-binding transcription factor activity
Syn6312_0661	COG0697	spore germination
Syn6312_0662	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Syn6312_0665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Syn6312_0666	COG0424	maF-like protein
Syn6312_0667	COG1376	ErfK ybiS ycfS ynhG family protein
Syn6312_0669	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Syn6312_0677	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Syn6312_0678	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Syn6312_0678	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Syn6312_0679	COG1716	ATPase activity
Syn6312_0679	COG5001	Diguanylate cyclase
Syn6312_0683	COG5002	protein histidine kinase activity
Syn6312_0683	COG2205	protein histidine kinase activity
Syn6312_0683	COG0784	Response regulator, receiver
Syn6312_0685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Syn6312_0686	COG0539	negative regulation of cytoplasmic translation
Syn6312_0687	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Syn6312_0691	COG1136	(ABC) transporter
Syn6312_0692	COG1136	(ABC) transporter
Syn6312_0692	COG0577	efflux transmembrane transporter activity
Syn6312_0707	COG2244	polysaccharide biosynthetic process
Syn6312_0709	COG1216	Glycosyl transferase, family 2
Syn6312_0710	COG1215	transferase activity, transferring glycosyl groups
Syn6312_0711	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Syn6312_0712	COG1216	Glycosyl transferase, family 2
Syn6312_0716	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Syn6312_0723	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Syn6312_0724	COG1132	(ABC) transporter
Syn6312_0725	COG0739	heme binding
Syn6312_0730	COG3411	Ferredoxin
Syn6312_0731	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Syn6312_0732	COG0463	Glycosyl transferase, family 2
Syn6312_0733	COG0110	maltose O-acetyltransferase activity
Syn6312_0734	COG0438	transferase activity, transferring glycosyl groups
Syn6312_0736	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Syn6312_0738	COG0438	transferase activity, transferring glycosyl groups
Syn6312_0743	COG1083	cytidylyl-transferase
Syn6312_0745	COG0110	maltose O-acetyltransferase activity
Syn6312_0747	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Syn6312_0753	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Syn6312_0754	COG1132	(ABC) transporter
Syn6312_0756	COG1596	polysaccharide export
Syn6312_0762	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Syn6312_0765	COG0501	Belongs to the peptidase M48B family
Syn6312_0766	COG1970	mechanosensitive ion channel activity
Syn6312_0771	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Syn6312_0772	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Syn6312_0774	COG0384	phenazine biosynthesis protein PhzF
Syn6312_0775	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Syn6312_0776	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Syn6312_0777	COG0515	serine threonine protein kinase
Syn6312_0780	COG0857	belongs to the CobB CobQ family
Syn6312_0783	COG1215	transferase activity, transferring glycosyl groups
Syn6312_0785	COG0586	Pfam SNARE associated Golgi protein
Syn6312_0786	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Syn6312_0787	COG0194	GDP metabolic process
Syn6312_0788	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Syn6312_0788	COG0426	domain, Protein
Syn6312_0789	COG1598	PFAM Uncharacterised protein family UPF0150
Syn6312_0794	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Syn6312_0794	COG0426	domain, Protein
Syn6312_0795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Syn6312_0796	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Syn6312_0797	COG0557	exoribonuclease II activity
Syn6312_0803	COG0793	Belongs to the peptidase S41A family
Syn6312_0804	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Syn6312_0808	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Syn6312_0812	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Syn6312_0813	COG0052	Belongs to the universal ribosomal protein uS2 family
Syn6312_0816	COG0564	pseudouridine synthase activity
Syn6312_0817	COG3437	response regulator, receiver
Syn6312_0818	COG1959	2 iron, 2 sulfur cluster binding
Syn6312_0819	COG1619	proteins homologs of microcin C7 resistance protein MccF
Syn6312_0821	COG0735	belongs to the Fur family
Syn6312_0828	COG1131	(ABC) transporter
Syn6312_0828	COG0842	Transport permease protein
Syn6312_0828	COG1716	ATPase activity
Syn6312_0831	COG2217	Heavy metal translocating P-type atpase
Syn6312_0844	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Syn6312_0845	COG1555	photosystem II stabilization
Syn6312_0847	COG1268	BioY protein
Syn6312_0851	COG0504	CTP synthase activity
Syn6312_0858	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Syn6312_0882	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Syn6312_0886	COG0732	type I restriction modification DNA specificity domain
Syn6312_0890	COG4636	protein conserved in cyanobacteria
Syn6312_0891	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Syn6312_0892	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Syn6312_0910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Syn6312_0912	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Syn6312_0917	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Syn6312_0923	COG0724	RNA recognition motif
Syn6312_0924	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Syn6312_0926	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Syn6312_0932	COG0210	DNA helicase
Syn6312_0932	COG0210	DNA helicase
Syn6312_0936	COG1666	GTP binding
Syn6312_0941	COG1166	arginine decarboxylase activity
Syn6312_0943	COG1122	ATPase activity
Syn6312_0945	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Syn6312_0946	COG0396	ATPase activity
Syn6312_0947	COG0719	Fe-S assembly protein
Syn6312_0950	COG2048	Heterodisulfide reductase, subunit B
Syn6312_0952	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Syn6312_0959	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Syn6312_0960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Syn6312_0962	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Syn6312_0964	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
Syn6312_0965	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Syn6312_0968	COG1494	fructose-1,6-bisphosphatase
Syn6312_0970	COG0335	large ribosomal subunit rRNA binding
Syn6312_0972	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Syn6312_0980	COG1555	photosystem II stabilization
Syn6312_0980	COG1234	tRNA 3'-trailer cleavage
Syn6312_0981	COG2307	Protein conserved in bacteria
Syn6312_0981	COG2308	Evidence 4 Homologs of previously reported genes of
Syn6312_0983	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Syn6312_0984	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Syn6312_0985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Syn6312_0986	COG0523	cobalamin synthesis protein
Syn6312_0989	COG0004	ammonium transporteR
Syn6312_0991	COG2884	Cell division ATP-binding protein ftsE
Syn6312_0994	COG0586	Pfam SNARE associated Golgi protein
Syn6312_0997	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Syn6312_1003	COG1733	regulation of RNA biosynthetic process
Syn6312_1011	COG1408	metallophosphoesterase
Syn6312_1013	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Syn6312_1016	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Syn6312_1017	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Syn6312_1039	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Syn6312_1040	COG0316	Belongs to the HesB IscA family
Syn6312_1041	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Syn6312_1042	COG0572	uridine kinase
Syn6312_1043	COG1193	negative regulation of DNA recombination
Syn6312_1044	COG1007	ATP synthesis coupled electron transport
Syn6312_1045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Syn6312_1048	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Syn6312_1050	COG0625	glutathione transferase activity
Syn6312_1051	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Syn6312_1053	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Syn6312_1067	COG1104	cysteine desulfurase activity
Syn6312_1068	COG0288	reversible hydration of carbon dioxide
Syn6312_1069	COG0167	dihydroorotate dehydrogenase activity
Syn6312_1073	COG0251	oxidation-reduction process
Syn6312_1075	COG1587	Uroporphyrinogen-III synthase
Syn6312_1076	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Syn6312_1078	COG1722	exodeoxyribonuclease VII activity
Syn6312_1079	COG0488	(ABC) transporter
Syn6312_1082	COG0134	indole-3-glycerol-phosphate synthase activity
Syn6312_1086	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Syn6312_1089	COG2197	response regulator
Syn6312_1090	COG4585	Histidine kinase
Syn6312_1094	COG1136	(ABC) transporter
Syn6312_1094	COG0577	efflux transmembrane transporter activity
Syn6312_1096	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Syn6312_1097	COG0583	DNA-binding transcription factor activity
Syn6312_1099	COG2223	nitrite transmembrane transporter activity
Syn6312_1100	COG0243	molybdopterin cofactor binding
Syn6312_1109	COG0303	'Molybdopterin
Syn6312_1110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Syn6312_1111	COG0315	cyclic pyranopterin monophosphate synthase activity
Syn6312_1111	COG0746	molybdenum cofactor guanylyltransferase activity
Syn6312_1113	COG0314	molybdopterin synthase activity
Syn6312_1114	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Syn6312_1120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Syn6312_1121	COG0589	response to stress
Syn6312_1124	COG0436	Aminotransferase
Syn6312_1128	COG0751	glycine-tRNA ligase activity
Syn6312_1132	COG0484	heat shock protein binding
Syn6312_1161	COG2369	cell adhesion
Syn6312_1163	COG5005	Phage virion morphogenesis
Syn6312_1174	COG0776	regulation of translation
Syn6312_1185	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Syn6312_1186	COG1468	defense response to virus
Syn6312_1186	COG1518	maintenance of DNA repeat elements
Syn6312_1190	COG1857	crispr-associated protein
Syn6312_1192	COG1203	CRISPR-associated helicase, Cas3
Syn6312_1201	COG0297	glycogen (starch) synthase activity
Syn6312_1202	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Syn6312_1203	COG2154	pterin-4-alpha-carbinolamine dehydratase
Syn6312_1209	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Syn6312_1214	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Syn6312_1215	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Syn6312_1217	COG1376	ErfK ybiS ycfS ynhG family protein
Syn6312_1219	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Syn6312_1221	COG0439	Biotin carboxylase
Syn6312_1223	COG2255	four-way junction helicase activity
Syn6312_1224	COG0483	inositol monophosphate 1-phosphatase activity
Syn6312_1231	COG2217	Heavy metal translocating P-type atpase
Syn6312_1232	COG0788	formyltetrahydrofolate deformylase activity
Syn6312_1235	COG0745	RESPONSE REGULATOR receiver
Syn6312_1237	COG0051	transcription antitermination factor activity, RNA binding
Syn6312_1238	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Syn6312_1239	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Syn6312_1240	COG0049	tRNA binding
Syn6312_1241	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Syn6312_1244	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Syn6312_1245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Syn6312_1246	COG0085	RNA polymerase activity
Syn6312_1247	COG4221	oxidoreductase activity
Syn6312_1257	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Syn6312_1258	COG0416	fatty acid biosynthetic process
Syn6312_1259	COG1716	ATPase activity
Syn6312_1260	COG0095	Lipoate-protein ligase
Syn6312_1261	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Syn6312_1262	COG2226	methyltransferase
Syn6312_1263	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Syn6312_1268	COG1797	cobyrinic acid a,c-diamide synthase activity
Syn6312_1275	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Syn6312_1276	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Syn6312_1277	COG0768	penicillin binding
Syn6312_1278	COG0463	Glycosyl transferase, family 2
Syn6312_1280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Syn6312_1281	COG2832	Protein of unknown function (DUF454)
Syn6312_1282	COG5001	Diguanylate cyclase
Syn6312_1282	COG4251	negative regulation of phosphorylation
Syn6312_1282	COG3706	GGDEF domain
Syn6312_1282	COG2203	Gaf domain
Syn6312_1290	COG0831	urea catabolic process
Syn6312_1291	COG0829	nickel cation binding
Syn6312_1292	COG3258	Cytochrome c
Syn6312_1295	COG1122	ATPase activity
Syn6312_1297	COG1473	amidohydrolase
Syn6312_1301	COG1294	oxidase, subunit
Syn6312_1302	COG1271	oxidase subunit
Syn6312_1303	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Syn6312_1305	COG0495	leucyl-tRNA aminoacylation
Syn6312_1309	COG1215	transferase activity, transferring glycosyl groups
Syn6312_1312	COG1216	Glycosyl transferase, family 2
Syn6312_1315	COG2837	iron assimilation
Syn6312_1316	COG2822	iron ion transport
Syn6312_1318	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Syn6312_1318	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Syn6312_1319	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Syn6312_1326	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Syn6312_1327	COG2319	Wd-40 repeat
Syn6312_1328	COG2319	Wd-40 repeat
Syn6312_1333	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Syn6312_1335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Syn6312_1339	COG2205	protein histidine kinase activity
Syn6312_1339	COG0784	Response regulator, receiver
Syn6312_1339	COG5002	protein histidine kinase activity
Syn6312_1342	COG0037	tRNA processing
Syn6312_1343	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Syn6312_1345	COG1073	alpha beta
Syn6312_1374	COG0248	Ppx GppA phosphatase
Syn6312_1376	COG2198	Histidine kinase
Syn6312_1376	COG0643	Histidine kinase
Syn6312_1377	COG2203	Gaf domain
Syn6312_1377	COG0840	transmembrane signaling receptor activity
Syn6312_1380	COG0784	Response regulator, receiver
Syn6312_1382	COG2003	Belongs to the UPF0758 family
Syn6312_1383	COG3659	wide pore channel activity
Syn6312_1386	COG0456	acetyltransferase
Syn6312_1386	COG0454	-acetyltransferase
Syn6312_1387	COG0019	diaminopimelate decarboxylase activity
Syn6312_1388	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Syn6312_1389	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Syn6312_1391	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Syn6312_1393	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Syn6312_1394	COG1773	rubredoxin
Syn6312_1395	COG4447	cellulose binding
Syn6312_1407	COG0322	excinuclease ABC activity
Syn6312_1408	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Syn6312_1418	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Syn6312_1419	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Syn6312_1429	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Syn6312_1431	COG1160	GTP binding
Syn6312_1432	COG3659	wide pore channel activity
Syn6312_1433	COG4597	amino acid ABC transporter
Syn6312_1434	COG0765	amino acid transport
Syn6312_1435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Syn6312_1437	COG0484	heat shock protein binding
Syn6312_1438	COG0287	Prephenate dehydrogenase
Syn6312_1445	COG0517	IMP dehydrogenase activity
Syn6312_1445	COG0516	GMP reductase activity
Syn6312_1447	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Syn6312_1449	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Syn6312_1451	COG0805	protein transport
Syn6312_1454	COG1175	transmembrane transport
Syn6312_1455	COG0628	permease
Syn6312_1460	COG0632	four-way junction helicase activity
Syn6312_1461	COG1657	PFAM Prenyltransferase squalene oxidase
Syn6312_1462	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Syn6312_1462	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Syn6312_1463	COG2890	protein-(glutamine-N5) methyltransferase activity
Syn6312_1464	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Syn6312_1465	COG3536	Protein conserved in bacteria
Syn6312_1467	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Syn6312_1468	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Syn6312_1470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Syn6312_1476	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Syn6312_1479	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Syn6312_1480	COG0436	Aminotransferase
Syn6312_1481	COG4221	oxidoreductase activity
Syn6312_1484	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Syn6312_1494	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Syn6312_1504	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Syn6312_1508	COG0302	gtp cyclohydrolase
Syn6312_1509	COG4221	oxidoreductase activity
Syn6312_1510	COG0825	malonyl-CoA metabolic process
Syn6312_1511	COG5322	oxidoreductase activity
Syn6312_1512	COG1606	tRNA processing
Syn6312_1513	COG1187	pseudouridine synthase activity
Syn6312_1514	COG0138	bifunctional purine biosynthesis protein purh
Syn6312_1517	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Syn6312_1518	COG0357	Ribosomal RNA small subunit methyltransferase G
Syn6312_1519	COG0310	cobalt ion transport
Syn6312_1522	COG2205	protein histidine kinase activity
Syn6312_1523	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Syn6312_1524	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Syn6312_1525	COG2066	Belongs to the glutaminase family
Syn6312_1526	COG0285	dihydrofolate synthase activity
Syn6312_1530	COG0737	Belongs to the 5'-nucleotidase family
Syn6312_1531	COG0058	SHG alpha-glucan phosphorylase activity
Syn6312_1532	COG5001	Diguanylate cyclase
Syn6312_1532	COG3706	GGDEF domain
Syn6312_1532	COG2203	Gaf domain
Syn6312_1532	COG4251	negative regulation of phosphorylation
Syn6312_1533	COG2204	response regulator
Syn6312_1536	COG0459	protein refolding
Syn6312_1538	COG1032	radical SAM domain protein
Syn6312_1539	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Syn6312_1540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Syn6312_1542	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Syn6312_1543	COG0745	RESPONSE REGULATOR receiver
Syn6312_1546	COG1733	regulation of RNA biosynthetic process
Syn6312_1547	COG1136	(ABC) transporter
Syn6312_1554	COG1309	transcriptional regulator
Syn6312_1558	COG3773	Cell wall hydrolase
Syn6312_1558	COG3409	Peptidoglycan-binding domain 1 protein
Syn6312_1559	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Syn6312_1562	COG1672	PFAM Archaeal ATPase
Syn6312_1562	COG2319	Wd-40 repeat
Syn6312_1566	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Syn6312_1568	COG3118	belongs to the thioredoxin family
Syn6312_1570	COG0516	GMP reductase activity
Syn6312_1572	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Syn6312_1577	COG0297	glycogen (starch) synthase activity
Syn6312_1582	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Syn6312_1583	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Syn6312_1585	COG0215	cysteine-tRNA ligase activity
Syn6312_1587	COG0649	NAD binding
Syn6312_1589	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Syn6312_1590	COG0406	alpha-ribazole phosphatase activity
Syn6312_1595	COG0574	Belongs to the PEP-utilizing enzyme family
Syn6312_1595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Syn6312_1597	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Syn6312_1598	COG1196	nuclear chromosome segregation
Syn6312_1601	COG0154	amidase activity
Syn6312_1604	COG0515	serine threonine protein kinase
Syn6312_1604	COG1357	PFAM Pentapeptide repeats (8 copies)
Syn6312_1607	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Syn6312_1608	COG0742	ribosomal rna small subunit methyltransferase
Syn6312_1609	COG2226	methyltransferase
Syn6312_1610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Syn6312_1612	COG4172	Belongs to the ABC transporter superfamily
Syn6312_1613	COG2385	sporulation resulting in formation of a cellular spore
Syn6312_1614	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Syn6312_1619	COG0346	lactoylglutathione lyase activity
Syn6312_1620	COG0431	NADPH-dependent FMN reductase
Syn6312_1624	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Syn6312_1628	COG0668	transmembrane transport
Syn6312_1635	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Syn6312_1635	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Syn6312_1640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Syn6312_1641	COG0385	Bile acid
Syn6312_1644	COG1316	TRANSCRIPTIONal
Syn6312_1645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Syn6312_1647	COG1012	belongs to the aldehyde dehydrogenase family
Syn6312_1651	COG0419	ATPase involved in DNA repair
Syn6312_1655	COG2226	methyltransferase
Syn6312_1658	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Syn6312_1659	COG2361	Protein of unknown function DUF86
Syn6312_1664	COG1562	ergosterol biosynthetic process
Syn6312_1665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Syn6312_1665	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Syn6312_1672	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Syn6312_1673	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Syn6312_1675	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Syn6312_1676	COG3842	ATPase activity
Syn6312_1678	COG1316	TRANSCRIPTIONal
Syn6312_1701	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Syn6312_1705	COG1846	Transcriptional regulator
Syn6312_1708	COG0514	ATP-dependent DNA helicase (RecQ)
Syn6312_1732	COG0159	tryptophan synthase activity
Syn6312_1733	COG0737	Belongs to the 5'-nucleotidase family
Syn6312_1736	COG0142	geranyltranstransferase activity
Syn6312_1737	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Syn6312_1740	COG1397	ADP-ribosylglycohydrolase
Syn6312_1748	COG3309	Virulence-associated protein D
Syn6312_1751	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Syn6312_1754	COG1289	transmembrane transporter activity
Syn6312_1756	COG0475	glutathione-regulated potassium exporter activity
Syn6312_1758	COG4451	ribulose bisphosphate carboxylase, small
Syn6312_1758	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Syn6312_1759	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Syn6312_1760	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Syn6312_1761	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Syn6312_1762	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Syn6312_1763	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Syn6312_1773	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Syn6312_1774	COG0644	oxidoreductase
Syn6312_1775	COG0515	serine threonine protein kinase
Syn6312_1777	COG0438	transferase activity, transferring glycosyl groups
Syn6312_1778	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Syn6312_1780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Syn6312_1785	COG0475	glutathione-regulated potassium exporter activity
Syn6312_1787	COG1366	Belongs to the anti-sigma-factor antagonist family
Syn6312_1789	COG0575	Belongs to the CDS family
Syn6312_1790	COG0484	heat shock protein binding
Syn6312_1791	COG0129	dihydroxy-acid dehydratase activity
Syn6312_1794	COG2197	response regulator
Syn6312_1795	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Syn6312_1796	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Syn6312_1799	COG0438	transferase activity, transferring glycosyl groups
Syn6312_1799	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Syn6312_1801	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Syn6312_1803	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Syn6312_1806	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Syn6312_1808	COG0181	hydroxymethylbilane synthase activity
Syn6312_1809	COG5001	Diguanylate cyclase
Syn6312_1811	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Syn6312_1812	COG0489	protein tyrosine kinase activity
Syn6312_1813	COG2205	protein histidine kinase activity
Syn6312_1816	COG1178	ABC-type Fe3 transport system permease component
Syn6312_1820	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Syn6312_1822	COG1136	(ABC) transporter
Syn6312_1827	COG1640	4-alpha-glucanotransferase
Syn6312_1833	COG2226	methyltransferase
Syn6312_1836	COG1131	(ABC) transporter
Syn6312_1839	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Syn6312_1844	COG0358	DNA primase activity
Syn6312_1854	COG0442	prolyl-tRNA aminoacylation
Syn6312_1857	COG4221	oxidoreductase activity
Syn6312_1860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Syn6312_1861	COG0670	Belongs to the BI1 family
Syn6312_1863	COG0525	valine-tRNA ligase activity
Syn6312_1866	COG0629	single-stranded DNA binding
Syn6312_1872	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Syn6312_1876	COG0832	Belongs to the urease beta subunit family
Syn6312_1878	COG0193	aminoacyl-tRNA hydrolase activity
Syn6312_1879	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Syn6312_1883	COG0250	Participates in transcription elongation, termination and antitermination
Syn6312_1884	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Syn6312_1885	COG0081	regulation of translation
Syn6312_1886	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Syn6312_1887	COG0222	ribosome binding
Syn6312_1890	COG0559	Belongs to the binding-protein-dependent transport system permease family
Syn6312_1892	COG0483	inositol monophosphate 1-phosphatase activity
Syn6312_1893	COG2010	Cytochrome c
Syn6312_1894	COG2010	Cytochrome c
Syn6312_1895	COG2010	Cytochrome c
Syn6312_1896	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Syn6312_1898	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Syn6312_1899	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Syn6312_1901	COG4251	negative regulation of phosphorylation
Syn6312_1901	COG5001	Diguanylate cyclase
Syn6312_1901	COG3706	GGDEF domain
Syn6312_1901	COG2203	Gaf domain
Syn6312_1903	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Syn6312_1907	COG2022	thiamine diphosphate biosynthetic process
Syn6312_1908	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Syn6312_1911	COG1357	PFAM Pentapeptide repeats (8 copies)
Syn6312_1911	COG0515	serine threonine protein kinase
Syn6312_1915	COG0673	inositol 2-dehydrogenase activity
Syn6312_1917	COG0009	L-threonylcarbamoyladenylate synthase
Syn6312_1920	COG5002	protein histidine kinase activity
Syn6312_1924	COG0789	Transcriptional regulator
Syn6312_1925	COG2329	Antibiotic biosynthesis monooxygenase
Syn6312_1926	COG1598	PFAM Uncharacterised protein family UPF0150
Syn6312_1933	COG1309	transcriptional regulator
Syn6312_1940	COG4178	(ABC) transporter
Syn6312_1941	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Syn6312_1944	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Syn6312_1947	COG2226	methyltransferase
Syn6312_1948	COG0339	signal peptide processing
Syn6312_1951	COG0477	Major facilitator Superfamily
Syn6312_1957	COG1598	PFAM Uncharacterised protein family UPF0150
Syn6312_1960	COG0006	proline dipeptidase activity
Syn6312_1962	COG0408	coproporphyrinogen oxidase activity
Syn6312_1965	COG0300	oxidoreductase activity
Syn6312_1969	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Syn6312_1972	COG1216	Glycosyl transferase, family 2
Syn6312_1973	COG1216	Glycosyl transferase, family 2
Syn6312_1974	COG1216	Glycosyl transferase, family 2
Syn6312_1975	COG1215	transferase activity, transferring glycosyl groups
Syn6312_1976	COG1216	Glycosyl transferase, family 2
Syn6312_1976	COG1442	glycosyl transferase family 8
Syn6312_1977	COG1028	Short-chain dehydrogenase reductase Sdr
Syn6312_1980	COG1132	(ABC) transporter
Syn6312_1987	COG2045	Belongs to the ComB family
Syn6312_1990	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Syn6312_2000	COG0463	Glycosyl transferase, family 2
Syn6312_2000	COG0457	Tetratricopeptide repeat
Syn6312_2001	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Syn6312_2002	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Syn6312_2005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Syn6312_2006	COG0124	histidyl-tRNA synthetase
Syn6312_2007	COG1850	ribulose-bisphosphate carboxylase activity
Syn6312_2009	COG4451	ribulose bisphosphate carboxylase, small
Syn6312_2011	COG1160	GTP binding
Syn6312_2012	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Syn6312_2014	COG0772	Belongs to the SEDS family
Syn6312_2016	COG0587	DNA-directed DNA polymerase activity
Syn6312_2020	COG1357	PFAM Pentapeptide repeats (8 copies)
Syn6312_2020	COG0515	serine threonine protein kinase
Syn6312_2023	COG5398	heme oxygenase
Syn6312_2024	COG0802	atpase or kinase
Syn6312_2029	COG1064	alcohol dehydrogenase
Syn6312_2030	COG3979	chitinase
Syn6312_2031	COG1575	Belongs to the MenA family. Type 1 subfamily
Syn6312_2053	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Syn6312_2054	COG1061	Type III restriction enzyme res subunit
Syn6312_2060	COG4636	protein conserved in cyanobacteria
Syn6312_2069	COG1895	HEPN domain
Syn6312_2075	COG1002	Type II restriction enzyme, methylase subunits
Syn6312_2079	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Syn6312_2089	COG1309	transcriptional regulator
Syn6312_2091	COG0135	phosphoribosylanthranilate isomerase activity
Syn6312_2100	COG1215	transferase activity, transferring glycosyl groups
Syn6312_2101	COG0716	FMN binding
Syn6312_2104	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Syn6312_2105	COG1192	Involved in chromosome partitioning
Syn6312_2108	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Syn6312_2109	COG1366	Belongs to the anti-sigma-factor antagonist family
Syn6312_2110	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
Syn6312_2111	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Syn6312_2112	COG1073	alpha beta
Syn6312_2113	COG0469	pyruvate kinase activity
Syn6312_2114	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Syn6312_2117	COG0752	glycyl-tRNA synthetase alpha subunit
Syn6312_2122	COG1082	Xylose isomerase domain protein TIM barrel
Syn6312_2126	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Syn6312_2131	COG1366	Belongs to the anti-sigma-factor antagonist family
Syn6312_2134	COG2770	Histidine kinase
Syn6312_2134	COG2208	phosphoserine phosphatase activity
Syn6312_2136	COG2223	nitrite transmembrane transporter activity
Syn6312_2137	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Syn6312_2147	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Syn6312_2149	COG0612	Peptidase, M16
Syn6312_2151	COG0582	viral genome integration into host DNA
Syn6312_2153	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Syn6312_2154	COG0363	glucosamine-6-phosphate deaminase activity
Syn6312_2155	COG1716	ATPase activity
Syn6312_2155	COG1716	ATPase activity
Syn6312_2157	COG0515	serine threonine protein kinase
Syn6312_2160	COG0126	phosphoglycerate kinase activity
Syn6312_2161	COG0589	response to stress
Syn6312_2163	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Syn6312_2164	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Syn6312_2165	COG3706	GGDEF domain
Syn6312_2165	COG4251	negative regulation of phosphorylation
Syn6312_2165	COG2203	Gaf domain
Syn6312_2165	COG5001	Diguanylate cyclase
Syn6312_2169	COG0601	transmembrane transport
Syn6312_2171	COG2176	DNA-directed DNA polymerase activity
Syn6312_2173	COG3842	ATPase activity
Syn6312_2177	COG0113	porphobilinogen synthase activity
Syn6312_2178	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Syn6312_2180	COG1136	(ABC) transporter
Syn6312_2180	COG0577	efflux transmembrane transporter activity
Syn6312_2181	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Syn6312_2181	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Syn6312_2182	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Syn6312_2186	COG2873	o-acetylhomoserine
Syn6312_2192	COG1285	pathogenesis
Syn6312_2193	COG2897	thiosulfate sulfurtransferase activity
Syn6312_2196	COG0312	modulator of DNA gyrase
Syn6312_2198	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Syn6312_2199	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Syn6312_2202	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Syn6312_2204	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Syn6312_2208	COG1132	(ABC) transporter
Syn6312_2212	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Syn6312_2215	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Syn6312_2216	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Syn6312_2219	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Syn6312_2221	COG0473	3-isopropylmalate dehydrogenase activity
Syn6312_2222	COG2208	phosphoserine phosphatase activity
Syn6312_2228	COG0783	Belongs to the Dps family
Syn6312_2230	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Syn6312_2236	COG0033	Phosphoglucomutase
Syn6312_2237	COG1077	Cell shape determining protein MreB Mrl
Syn6312_2238	COG1792	Involved in formation and maintenance of cell shape
Syn6312_2240	COG0463	Glycosyl transferase, family 2
Syn6312_2240	COG0457	Tetratricopeptide repeat
Syn6312_2242	COG0436	Aminotransferase
Syn6312_2243	COG0371	Dehydrogenase
Syn6312_2255	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Syn6312_2256	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Syn6312_2259	COG0641	radical SAM
Syn6312_2262	COG0351	phosphomethylpyrimidine kinase
Syn6312_2263	COG1716	ATPase activity
Syn6312_2263	COG0842	Transport permease protein
Syn6312_2263	COG1131	(ABC) transporter
Syn6312_2265	COG1570	exodeoxyribonuclease VII activity
Syn6312_2270	COG0066	3-isopropylmalate dehydratase activity
Syn6312_2271	COG3842	ATPase activity
Syn6312_2272	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Syn6312_2277	COG1192	Involved in chromosome partitioning
Syn6312_2279	COG4636	protein conserved in cyanobacteria
Syn6312_2280	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Syn6312_2283	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Syn6312_2287	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
Syn6312_2288	COG1492	cobalamin metabolic process
Syn6312_2290	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Syn6312_2291	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Syn6312_2299	COG0745	RESPONSE REGULATOR receiver
Syn6312_2300	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Syn6312_2304	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Syn6312_2304	COG0072	phenylalanine-tRNA ligase activity
Syn6312_2307	COG1937	Protein conserved in bacteria
Syn6312_2311	COG3046	protein related to deoxyribodipyrimidine photolyase
Syn6312_2313	COG0583	DNA-binding transcription factor activity
Syn6312_2314	COG1131	(ABC) transporter
Syn6312_2315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Syn6312_2317	COG0463	Glycosyl transferase, family 2
Syn6312_2317	COG1216	Glycosyl transferase, family 2
Syn6312_2319	COG0297	glycogen (starch) synthase activity
Syn6312_2321	COG0438	transferase activity, transferring glycosyl groups
Syn6312_2323	COG0297	glycogen (starch) synthase activity
Syn6312_2324	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Syn6312_2324	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Syn6312_2325	COG0084	hydrolase, TatD family'
Syn6312_2326	COG0268	Binds directly to 16S ribosomal RNA
Syn6312_2328	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Syn6312_2329	COG1716	ATPase activity
Syn6312_2329	COG0842	Transport permease protein
Syn6312_2329	COG1131	(ABC) transporter
Syn6312_2330	COG0107	imidazoleglycerol-phosphate synthase activity
Syn6312_2331	COG3341	Caulimovirus viroplasmin
Syn6312_2331	COG0328	RNA-DNA hybrid ribonuclease activity
Syn6312_2332	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Syn6312_2333	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Syn6312_2344	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Syn6312_2346	COG0114	fumarate hydratase activity
Syn6312_2351	COG0508	dehydrogenase complex catalyzes the overall conversion of
Syn6312_2352	COG1672	PFAM Archaeal ATPase
Syn6312_2358	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Syn6312_2359	COG0477	Major facilitator Superfamily
Syn6312_2360	COG1381	Involved in DNA repair and RecF pathway recombination
Syn6312_2364	COG1132	(ABC) transporter
Syn6312_2369	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Syn6312_2374	COG1968	undecaprenyl-diphosphatase activity
Syn6312_2378	COG1530	ribonuclease E activity
Syn6312_2384	COG1489	DNA binding
Syn6312_2387	COG0326	Molecular chaperone. Has ATPase activity
Syn6312_2392	COG0105	UTP biosynthetic process
Syn6312_2393	COG0861	Integral membrane protein TerC family
Syn6312_2402	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Syn6312_2403	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Syn6312_2408	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Syn6312_2409	COG0148	phosphopyruvate hydratase activity
Syn6312_2411	COG0686	Belongs to the AlaDH PNT family
Syn6312_2413	COG0003	Pfam Anion-transporting ATPase
Syn6312_2415	COG0180	Tryptophanyl-tRNA synthetase
Syn6312_2416	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Syn6312_2419	COG0641	radical SAM
Syn6312_2420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Syn6312_2421	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Syn6312_2422	COG1595	DNA-templated transcription, initiation
Syn6312_2426	COG1305	Transglutaminase-like
Syn6312_2431	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Syn6312_2432	COG3937	granule-associated protein
Syn6312_2434	COG0131	Imidazoleglycerol-phosphate dehydratase
Syn6312_2437	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Syn6312_2437	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Syn6312_2440	COG0719	Fe-S assembly protein
Syn6312_2442	COG2894	cell division
Syn6312_2443	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Syn6312_2445	COG0395	ABC-type sugar transport system, permease component
Syn6312_2448	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Syn6312_2454	COG0646	methionine synthase
Syn6312_2454	COG1410	methionine synthase
Syn6312_2458	COG1598	PFAM Uncharacterised protein family UPF0150
Syn6312_2461	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Syn6312_2463	COG2361	Protein of unknown function DUF86
Syn6312_2464	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Syn6312_2467	COG4968	Prepilin-type N-terminal cleavage methylation domain
Syn6312_2469	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Syn6312_2471	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Syn6312_2472	COG0410	ABC transporter
Syn6312_2473	COG0569	domain protein
Syn6312_2481	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Syn6312_2482	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Syn6312_2483	COG0824	Thioesterase
Syn6312_2486	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Syn6312_2488	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Syn6312_2489	COG1799	cell septum assembly
Syn6312_2490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Syn6312_2491	COG0018	arginyl-trna synthetase
Syn6312_2498	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Syn6312_2501	COG0237	dephospho-CoA kinase activity
Syn6312_2502	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Syn6312_2503	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Syn6312_2504	COG1413	lyase activity
Syn6312_2505	COG1413	lyase activity
Syn6312_2506	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Syn6312_2507	COG0237	dephospho-CoA kinase activity
Syn6312_2510	COG1725	Transcriptional regulator
Syn6312_2511	COG0523	cobalamin synthesis protein
Syn6312_2515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Syn6312_2518	COG0006	proline dipeptidase activity
Syn6312_2520	COG0372	Belongs to the citrate synthase family
Syn6312_2521	COG0151	Belongs to the GarS family
Syn6312_2522	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Syn6312_2525	COG0484	heat shock protein binding
Syn6312_2526	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Syn6312_2527	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Syn6312_2529	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Syn6312_2535	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Syn6312_2536	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Syn6312_2539	COG2273	Hydrolase Family 16
Syn6312_2539	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Syn6312_2549	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Syn6312_2551	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Syn6312_2557	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Syn6312_2558	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Syn6312_2559	COG1555	photosystem II stabilization
Syn6312_2559	COG1234	tRNA 3'-trailer cleavage
Syn6312_2562	COG0411	ABC transporter
Syn6312_2563	COG0410	ABC transporter
Syn6312_2564	COG0406	alpha-ribazole phosphatase activity
Syn6312_2569	COG1959	2 iron, 2 sulfur cluster binding
Syn6312_2570	COG0681	Belongs to the peptidase S26 family
Syn6312_2571	COG3932	Exopolysaccharide synthesis, ExoD
Syn6312_2580	COG0653	protein targeting
Syn6312_2582	COG0517	IMP dehydrogenase activity
Syn6312_2582	COG1994	Peptidase M50
Syn6312_2585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Syn6312_2587	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Syn6312_2592	COG0753	catalase activity
Syn6312_2593	COG0525	valine-tRNA ligase activity
Syn6312_2601	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Syn6312_2603	COG2912	Transglutaminase-like superfamily
Syn6312_2610	COG0305	Participates in initiation and elongation during chromosome replication
Syn6312_2610	COG1372	Participates in initiation and elongation during chromosome replication
Syn6312_2610	COG1372	Participates in initiation and elongation during chromosome replication
Syn6312_2610	COG0305	Participates in initiation and elongation during chromosome replication
Syn6312_2612	COG0799	negative regulation of ribosome biogenesis
Syn6312_2613	COG1713	HD superfamily hydrolase involved in NAD metabolism
Syn6312_2614	COG1357	PFAM Pentapeptide repeats (8 copies)
Syn6312_2614	COG0515	serine threonine protein kinase
Syn6312_2615	COG5002	protein histidine kinase activity
Syn6312_2616	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Syn6312_2618	COG0681	Belongs to the peptidase S26 family
Syn6312_2619	COG1070	Carbohydrate kinase
Syn6312_2621	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Syn6312_2623	COG0625	glutathione transferase activity
Syn6312_2624	COG3795	YCII-related domain
Syn6312_2625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Syn6312_2626	COG1842	Phage shock protein A
Syn6312_2628	COG3659	wide pore channel activity
Syn6312_2629	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Syn6312_2630	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Syn6312_2631	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Syn6312_2632	COG4208	sulfate ABC transporter
Syn6312_2633	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Syn6312_2634	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Syn6312_2635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Syn6312_2636	COG1045	serine acetyltransferase
Syn6312_2637	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Syn6312_2638	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Syn6312_2642	COG0728	peptidoglycan biosynthetic process
Syn6312_2644	COG0582	viral genome integration into host DNA
Syn6312_2646	COG5002	protein histidine kinase activity
Syn6312_2646	COG0784	Response regulator, receiver
Syn6312_2646	COG2205	protein histidine kinase activity
Syn6312_2647	COG2770	Histidine kinase
Syn6312_2647	COG2208	phosphoserine phosphatase activity
Syn6312_2648	COG3706	GGDEF domain
Syn6312_2648	COG0745	RESPONSE REGULATOR receiver
Syn6312_2649	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Syn6312_2656	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Syn6312_2658	COG2062	phosphohistidine phosphatase, SixA
Syn6312_2662	COG1253	flavin adenine dinucleotide binding
Syn6312_2666	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Syn6312_2667	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Syn6312_2670	COG1132	(ABC) transporter
Syn6312_2671	COG1045	serine acetyltransferase
Syn6312_2673	COG0717	Belongs to the dCTP deaminase family
Syn6312_2674	COG1216	Glycosyl transferase, family 2
Syn6312_2687	COG0747	negative chemotaxis
Syn6312_2689	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Syn6312_2693	COG0237	dephospho-CoA kinase activity
Syn6312_2695	COG0438	transferase activity, transferring glycosyl groups
Syn6312_2698	COG0628	permease
Syn6312_2699	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Syn6312_2700	COG2264	protein methyltransferase activity
Syn6312_2704	COG0791	NLP P60 protein
Syn6312_2704	COG0741	lytic transglycosylase activity
Syn6312_2706	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Syn6312_2709	COG3951	Flagellar rod assembly protein muramidase FlgJ
Syn6312_2709	COG1705	Flagellar rod assembly protein muramidase FlgJ
Syn6312_2726	COG5002	protein histidine kinase activity
Syn6312_2727	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Syn6312_2730	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Syn6312_2732	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Syn6312_2733	COG2205	protein histidine kinase activity
Syn6312_2734	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Syn6312_2737	COG0745	RESPONSE REGULATOR receiver
Syn6312_2738	COG0598	Magnesium transport protein CorA
Syn6312_2739	COG3118	belongs to the thioredoxin family
Syn6312_2744	COG0179	Fumarylacetoacetate (FAA) hydrolase
Syn6312_2745	COG0360	Binds together with S18 to 16S ribosomal RNA
Syn6312_2759	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Syn6312_2764	COG0514	ATP-dependent DNA helicase (RecQ)
Syn6312_2795	COG0640	Transcriptional regulator
Syn6312_2796	COG2217	Heavy metal translocating P-type atpase
Syn6312_2797	COG0789	Transcriptional regulator
Syn6312_2815	COG3177	Filamentation induced by cAMP protein fic
Syn6312_2816	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Syn6312_2823	COG0484	heat shock protein binding
Syn6312_2833	COG3548	integral membrane protein
Syn6312_2862	COG1468	defense response to virus
Syn6312_2862	COG1518	maintenance of DNA repeat elements
Syn6312_2872	COG0484	heat shock protein binding
Syn6312_2884	COG1943	Transposase
Syn6312_2919	COG3706	GGDEF domain
Syn6312_2919	COG2203	Gaf domain
Syn6312_2919	COG4251	negative regulation of phosphorylation
Syn6312_2919	COG5001	Diguanylate cyclase
Syn6312_2920	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Syn6312_2924	COG0069	glutamate synthase activity
Syn6312_2924	COG0070	glutamate synthase
Syn6312_2924	COG0067	glutamate synthase
Syn6312_2926	COG0375	protein maturation
Syn6312_2928	COG0010	Belongs to the arginase family
Syn6312_2940	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Syn6312_2941	COG3409	Peptidoglycan-binding domain 1 protein
Syn6312_2941	COG3429	Glucose-6-phosphate dehydrogenase subunit
Syn6312_2948	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Syn6312_2949	COG2226	methyltransferase
Syn6312_2950	COG1104	cysteine desulfurase activity
Syn6312_2952	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Syn6312_2954	COG1122	ATPase activity
Syn6312_2956	COG2226	methyltransferase
Syn6312_2957	COG0848	biopolymer transport protein
Syn6312_2958	COG0811	peptide transport
Syn6312_2960	COG1429	ligase activity, forming nitrogen-metal bonds
Syn6312_2961	COG0464	growth
Syn6312_2962	COG1404	Belongs to the peptidase S8 family
Syn6312_2968	COG3848	Pyruvate phosphate dikinase
Syn6312_2968	COG0574	Belongs to the PEP-utilizing enzyme family
Syn6312_2970	COG0730	response to heat
Syn6312_2971	COG0786	glutamate:sodium symporter activity
Syn6312_2973	COG2264	protein methyltransferase activity
Syn6312_2984	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Syn6312_2987	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Syn6312_2988	COG0528	UMP kinase activity
Syn6312_2989	COG0233	cytoplasmic translational termination
Syn6312_2991	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Syn6312_2992	COG1049	propionate catabolic process, 2-methylcitrate cycle
Syn6312_3002	COG0646	methionine synthase
Syn6312_3002	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Syn6312_3003	COG2211	Major facilitator Superfamily
Syn6312_3007	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Syn6312_3010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Syn6312_3018	COG0659	secondary active sulfate transmembrane transporter activity
Syn6312_3020	COG1063	alcohol dehydrogenase
Syn6312_3024	COG0456	acetyltransferase
Syn6312_3025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Syn6312_3026	COG0573	inorganic phosphate transmembrane transporter activity
Syn6312_3028	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Syn6312_3040	COG1476	TRANSCRIPTIONal
Syn6312_3049	COG0174	glutamine synthetase
Syn6312_3052	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Syn6312_3054	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Syn6312_3058	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Syn6312_3058	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Syn6312_3059	COG0515	serine threonine protein kinase
Syn6312_3061	COG1982	Orn Lys Arg decarboxylase major
Syn6312_3065	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Syn6312_3066	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Syn6312_3072	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Syn6312_3076	COG0017	Asparaginyl-tRNA synthetase
Syn6312_3077	COG5002	protein histidine kinase activity
Syn6312_3078	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Syn6312_3079	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Syn6312_3080	COG0776	regulation of translation
Syn6312_3081	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Syn6312_3082	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Syn6312_3093	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Syn6312_3095	COG0724	RNA recognition motif
Syn6312_3096	COG0542	response to heat
Syn6312_3098	COG2022	thiamine diphosphate biosynthetic process
Syn6312_3098	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Syn6312_3100	COG2133	pyrroloquinoline quinone binding
Syn6312_3101	COG0542	response to heat
Syn6312_3102	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Syn6312_3103	COG1191	sigma factor activity
Syn6312_3108	COG0768	penicillin binding
Syn6312_3111	COG0726	polysaccharide deacetylase
Syn6312_3114	COG0792	nuclease activity
Syn6312_3116	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Syn6312_3118	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Syn6312_3119	COG4251	negative regulation of phosphorylation
Syn6312_3122	COG1214	PFAM Peptidase M22, glycoprotease
Syn6312_3126	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Syn6312_3128	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Syn6312_3129	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Syn6312_3130	COG1116	anion transmembrane transporter activity
Syn6312_3130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Syn6312_3131	COG1116	anion transmembrane transporter activity
Syn6312_3132	COG5001	Diguanylate cyclase
Syn6312_3132	COG1716	ATPase activity
Syn6312_3135	COG0484	heat shock protein binding
Syn6312_3136	COG0443	Heat shock 70 kDa protein
Syn6312_3137	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Syn6312_3139	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Syn6312_3140	COG4399	Belongs to the UPF0754 family
Syn6312_3141	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Syn6312_3142	COG1185	polyribonucleotide nucleotidyltransferase activity
Syn6312_3149	COG0330	HflC and HflK could
Syn6312_3157	COG3604	Transcriptional regulator
Syn6312_3159	COG2199	diguanylate cyclase activity
Syn6312_3159	COG2200	EAL domain
Syn6312_3159	COG2203	Gaf domain
Syn6312_3163	COG0254	rRNA binding
Syn6312_3164	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Syn6312_3165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Syn6312_3167	COG0203	ribosomal protein L17
Syn6312_3168	COG0202	RNA polymerase activity
Syn6312_3169	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Syn6312_3170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Syn6312_3171	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Syn6312_3172	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Syn6312_3173	COG0563	adenylate kinase activity
Syn6312_3174	COG0201	protein transport
Syn6312_3175	COG0200	Binds to the 23S rRNA
Syn6312_3176	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Syn6312_3177	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Syn6312_3178	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Syn6312_3179	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Syn6312_3180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Syn6312_3181	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Syn6312_3182	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Syn6312_3184	COG0255	Belongs to the universal ribosomal protein uL29 family
Syn6312_3185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Syn6312_3186	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Syn6312_3188	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Syn6312_3189	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Syn6312_3190	COG0089	rRNA binding
Syn6312_3191	COG0088	Forms part of the polypeptide exit tunnel
Syn6312_3192	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Syn6312_3194	COG2140	Oxalate decarboxylase
Syn6312_3199	COG2308	Evidence 4 Homologs of previously reported genes of
Syn6312_3202	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Syn6312_3204	COG0259	pyridoxamine-phosphate oxidase activity
Syn6312_3206	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Syn6312_3206	COG0475	glutathione-regulated potassium exporter activity
Syn6312_3211	COG0747	negative chemotaxis
Syn6312_3213	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Syn6312_3217	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Syn6312_3222	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Syn6312_3224	COG2119	membrane
Syn6312_3226	COG1691	(AIR) carboxylase
Syn6312_3227	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Syn6312_3232	COG1032	radical SAM domain protein
Syn6312_3236	COG1573	uracil-dna glycosylase
Syn6312_3237	COG0483	inositol monophosphate 1-phosphatase activity
Syn6312_3241	COG1121	(ABC) transporter
Syn6312_3242	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Syn6312_3243	COG0440	acetolactate synthase activity
Syn6312_3245	COG0745	RESPONSE REGULATOR receiver
Syn6312_3246	COG5002	protein histidine kinase activity
Syn6312_3247	COG1187	pseudouridine synthase activity
Syn6312_3250	COG3185	4-Hydroxyphenylpyruvate dioxygenase
Syn6312_3255	COG1546	Belongs to the CinA family
Syn6312_3255	COG1058	Belongs to the CinA family
Syn6312_3256	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Syn6312_3257	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Syn6312_3259	COG0366	Alpha amylase catalytic
Syn6312_3264	COG1543	Belongs to the glycosyl hydrolase 57 family
Syn6312_3265	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Syn6312_3266	COG3659	wide pore channel activity
Syn6312_3268	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Syn6312_3270	COG0519	Catalyzes the synthesis of GMP from XMP
Syn6312_3270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Syn6312_3271	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Syn6312_3272	COG0321	lipoyl(octanoyl) transferase activity
Syn6312_3273	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Syn6312_3275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Syn6312_3278	COG0038	chloride channel
Syn6312_3281	COG0116	Belongs to the methyltransferase superfamily
Syn6312_3286	COG0025	NhaP-type Na H and K H
Syn6312_3287	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Syn6312_3291	COG1473	amidohydrolase
Syn6312_3294	COG0137	argininosuccinate synthase activity
Syn6312_3297	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Syn6312_3298	COG0740	serine-type endopeptidase activity
Syn6312_3302	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Syn6312_3303	COG0587	DNA-directed DNA polymerase activity
Syn6312_3306	COG1899	peptidyl-lysine modification to peptidyl-hypusine
Syn6312_3312	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Syn6312_3318	COG1940	carbohydrate kinase activity
Syn6312_3321	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Syn6312_3327	COG2205	protein histidine kinase activity
Syn6312_3330	COG0012	GTP binding
Syn6312_3332	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Syn6312_3354	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Syn6312_3361	COG0582	viral genome integration into host DNA
Syn6312_3364	COG0745	RESPONSE REGULATOR receiver
Syn6312_3367	COG2211	Major facilitator Superfamily
Syn6312_3368	COG0562	UDP-galactopyranose mutase
Syn6312_3370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Syn6312_3374	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Syn6312_3377	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Syn6312_3380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Syn6312_3383	COG0174	glutamine synthetase
Syn6312_3385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Syn6312_3389	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Syn6312_3392	COG1420	regulation of RNA biosynthetic process
Syn6312_3393	COG0556	nucleotide-excision repair
Syn6312_3399	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Syn6312_3400	COG0297	glycogen (starch) synthase activity
Syn6312_3403	COG3118	belongs to the thioredoxin family
Syn6312_3407	COG1597	lipid kinase activity
Syn6312_3407	COG1803	Methylglyoxal synthase
Syn6312_3409	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Syn6312_3411	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Syn6312_3413	COG0242	peptide deformylase activity
Syn6312_3414	COG0438	transferase activity, transferring glycosyl groups
Syn6312_3417	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Syn6312_3418	COG0511	ligase activity, forming carbon-carbon bonds
Syn6312_3421	COG4783	chaperone-mediated protein folding
Syn6312_3423	COG4172	Belongs to the ABC transporter superfamily
Syn6312_3425	COG0454	-acetyltransferase
Syn6312_3430	COG0077	Prephenate dehydratase
Syn6312_3435	COG0574	Belongs to the PEP-utilizing enzyme family
Syn6312_3435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Syn6312_3436	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Syn6312_3437	COG3956	TIGRFAM MazG family protein
Syn6312_3439	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Syn6312_3441	COG1132	(ABC) transporter
Syn6312_3446	COG0505	Belongs to the CarA family
Syn6312_3450	COG0724	RNA recognition motif
Syn6312_3451	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Syn6312_3455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Syn6312_3456	COG1252	NADH dehydrogenase
Syn6312_3459	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Syn6312_3461	COG0481	GTPase activity
Syn6312_3463	COG1056	cytidyltransferase-related domain
Syn6312_3463	COG1051	belongs to the nudix hydrolase family
Syn6312_3464	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Syn6312_3465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Syn6312_3466	COG0024	Methionine aminopeptidase
Syn6312_3467	COG0701	Predicted permease
Syn6312_3469	COG0271	Belongs to the BolA IbaG family
Syn6312_3472	COG0237	dephospho-CoA kinase activity
Syn6312_3472	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Syn6312_3474	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Syn6312_3475	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Syn6312_3477	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Syn6312_3478	COG1598	PFAM Uncharacterised protein family UPF0150
Syn6312_3482	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Syn6312_3486	COG0517	IMP dehydrogenase activity
Syn6312_3486	COG0516	GMP reductase activity
Syn6312_3488	COG0616	signal peptide processing
Syn6312_3492	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Syn6312_3493	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Syn6312_3494	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Syn6312_3495	COG2252	PERMEase
Syn6312_3503	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Syn6312_3504	COG0443	Heat shock 70 kDa protein
Syn6312_3505	COG0463	Glycosyl transferase, family 2
Syn6312_3509	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Syn6312_3510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Syn6312_3511	COG4636	protein conserved in cyanobacteria
Syn6312_3525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Syn6312_3527	COG0482	sulfurtransferase activity
Syn6312_3528	COG0697	spore germination
Syn6312_3532	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Syn6312_3533	COG0123	including yeast histone deacetylase and acetoin utilization protein
Syn6312_3539	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Syn6312_3539	COG0140	phosphoribosyl-ATP diphosphatase activity
Syn6312_3549	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Syn6312_3552	COG0741	lytic transglycosylase activity
Syn6312_3553	COG0708	Exodeoxyribonuclease III
Syn6312_3555	COG0450	alkyl hydroperoxide reductase
Syn6312_3560	COG0740	serine-type endopeptidase activity
Syn6312_3567	COG0702	epimerase
Syn6312_3568	COG1040	competence protein
Syn6312_3569	COG0336	Belongs to the RNA methyltransferase TrmD family
Syn6312_3571	COG2205	protein histidine kinase activity
Syn6312_3573	COG1063	alcohol dehydrogenase
Syn6312_3574	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Syn6312_3576	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Syn6312_3580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Syn6312_3582	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Syn6312_3583	COG0429	hydrolase of the alpha beta-hydrolase fold
Syn6312_3585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Syn6312_3587	COG0573	inorganic phosphate transmembrane transporter activity
Syn6312_3588	COG0581	inorganic phosphate transmembrane transporter activity
Syn6312_3590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Syn6312_3590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Syn6312_3593	COG0460	homoserine dehydrogenase
Syn6312_3594	COG3264	Mechanosensitive ion channel
Syn6312_3594	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Syn6312_3596	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Syn6312_3602	COG0793	Belongs to the peptidase S41A family
Syn6312_3604	COG1078	dGTPase activity
Syn6312_3613	COG2202	Pas domain
Syn6312_3613	COG2205	protein histidine kinase activity
Syn6312_3614	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Syn6312_3620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Syn6312_3621	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Syn6312_3623	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Syn6312_3626	COG0577	efflux transmembrane transporter activity
Syn6312_3626	COG1136	(ABC) transporter
Syn6312_3628	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Syn6312_3629	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Syn6312_3633	COG0316	Belongs to the HesB IscA family
Syn6312_3634	COG0662	Cupin 2, conserved barrel domain protein
Syn6312_3634	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Syn6312_3637	COG4956	integral membrane protein (PIN domain superfamily)
Syn6312_3639	COG0420	3'-5' exonuclease activity
Syn6312_3640	COG5001	Diguanylate cyclase
Syn6312_3640	COG3706	GGDEF domain
Syn6312_3640	COG2203	Gaf domain
Syn6312_3640	COG4251	negative regulation of phosphorylation
Syn6312_3643	COG0456	acetyltransferase
Syn6312_3645	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Syn6312_3648	COG0415	Belongs to the DNA photolyase family
Syn6312_3649	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Syn6312_3650	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Syn6312_3662	COG4106	trans-aconitate 2-methyltransferase activity
Syn6312_3663	COG3781	membrane
Syn6312_3664	COG0157	Belongs to the NadC ModD family
Syn6312_3665	COG0583	DNA-binding transcription factor activity
Syn6312_3667	COG0412	Dienelactone hydrolase
Syn6312_3669	COG1028	Short-chain dehydrogenase reductase Sdr
Syn6312_3670	COG0312	modulator of DNA gyrase
Syn6312_3672	COG0784	Response regulator, receiver
Syn6312_3675	COG2203	Gaf domain
Syn6312_3675	COG0840	transmembrane signaling receptor activity
Syn6312_3679	COG1472	Belongs to the glycosyl hydrolase 3 family
Syn6312_3682	COG4969	Belongs to the N-Me-Phe pilin family
Syn6312_3685	COG0704	Plays a role in the regulation of phosphate uptake
Syn6312_3686	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Syn6312_3687	COG0740	serine-type endopeptidase activity
Syn6312_3688	COG0544	peptidyl-prolyl cis-trans isomerase activity
Syn6312_3694	COG0228	four-way junction DNA binding
Syn6312_3696	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Syn6312_3697	COG1702	phosphate starvation-inducible protein PhoH
Syn6312_3698	COG1357	PFAM Pentapeptide repeats (8 copies)
Syn6312_3698	COG0515	serine threonine protein kinase
Syn6312_3700	COG1131	(ABC) transporter
Syn6312_3701	COG0542	response to heat
Syn6312_3705	COG0277	FAD linked oxidase domain protein
Syn6312_3709	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Syn6312_3710	COG0850	regulation of cytokinetic process
Syn6312_3712	COG3903	Transcriptional regulator
Syn6312_3712	COG2319	Wd-40 repeat
Syn6312_3715	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Syn6312_3715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Syn6312_3716	COG1615	UPF0182 protein
Syn6312_3717	COG3527	Alpha-acetolactate decarboxylase
Syn6312_3722	COG0492	ferredoxin-NADP+ reductase activity
Syn6312_3725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Syn6312_3731	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Syn6312_3732	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Syn6312_3733	COG0058	SHG alpha-glucan phosphorylase activity
Syn6312_3734	COG0456	acetyltransferase
Syn6312_3736	COG0454	-acetyltransferase
Syn6312_3740	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Syn6312_3741	COG0189	ligase activity
Syn6312_3742	COG2205	protein histidine kinase activity
Syn6312_3742	COG3437	response regulator, receiver
Syn6312_3742	COG3850	Histidine kinase
Syn6312_3742	COG4999	Histidine kinase
Syn6312_3746	COG0778	Nitroreductase
Syn6312_3748	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Syn6312_3750	COG0163	prenyltransferase activity
Syn6312_3752	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Syn6312_3755	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Syn6312_3759	COG0706	membrane insertase activity
Syn6312_3762	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Syn6312_3793	COG1061	Type III restriction enzyme res subunit