locus-tag class description AWQ21_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AWQ21_00010 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AWQ21_00035 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) AWQ21_00040 ENOG4108V3E phosphoribosylglycinamide formyltransferase AWQ21_00045 ENOG4105CJT Mannose-1-phosphate guanylyltransferase AWQ21_00095 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AWQ21_00100 ENOG4106H78 methyltransferase AWQ21_00125 ENOG4105DWF phosphomethylpyrimidine kinase AWQ21_00130 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AWQ21_00140 ENOG4105DBI uridine monophosphokinase AWQ21_00160 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase AWQ21_00165 ENOG4105CRK lysyL-tRNA synthetase AWQ21_00220 ENOG4105M3Z response regulator AWQ21_00235 ENOG4105CBS Chea signal transduction histidine kinase AWQ21_00250 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AWQ21_00255 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AWQ21_00285 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AWQ21_00295 ENOG4105M6F mutator MutT protein AWQ21_00300 ENOG4107Z8V Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AWQ21_00310 ENOG4105DJZ UPF0182 protein AWQ21_00315 ENOG4105CGH 5'-nucleotidase AWQ21_00325 ENOG4105CNG UPF0061 protein AWQ21_00330 ENOG4105EVY Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) AWQ21_00335 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AWQ21_00340 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AWQ21_00345 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AWQ21_00355 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AWQ21_00360 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AWQ21_00365 ENOG41082QS Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AWQ21_00370 ENOG4105D17 glycoside hydrolase, family 3 domain protein AWQ21_00395 ENOG4105EYW Ion transport protein AWQ21_00415 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AWQ21_00420 ENOG4105CHR reductase AWQ21_00425 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AWQ21_00450 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AWQ21_00465 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AWQ21_00470 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AWQ21_00475 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AWQ21_00490 ENOG4105C8B TIGR00159 family AWQ21_00495 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AWQ21_00520 ENOG41082EZ Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AWQ21_00525 ENOG4105D4A Cell wall formation (By similarity) AWQ21_00530 ENOG4105DFU Cell wall formation (By similarity) AWQ21_00545 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) AWQ21_00550 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AWQ21_00560 ENOG4108UQX Low-potential cytochrome c that plays a role in the oxygen-evolving complex of photosystem II (By similarity) AWQ21_00595 ENOG41080E3 single-stranded DNA-binding protein AWQ21_00600 ENOG4108JQ6 ABC transporter AWQ21_00610 ENOG4108YZ4 nudix hydrolase AWQ21_00615 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AWQ21_00620 ENOG4105EG6 Saccharopine dehydrogenase AWQ21_00625 ENOG4105TMB Formate nitrite transporter AWQ21_00630 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase AWQ21_00675 ENOG4105ZDH Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna (By similarity) AWQ21_00680 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AWQ21_00690 ENOG4108JQC penicillin-binding protein 1A AWQ21_00695 ENOG4105ETX regulatoR AWQ21_00705 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AWQ21_00720 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AWQ21_00730 ENOG4105F23 Fibronectin-binding protein AWQ21_00735 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AWQ21_00740 ENOG4105BZU Histidine kinase AWQ21_00755 ENOG4105CGH 5'-nucleotidase AWQ21_00770 ENOG4105VUV UPF0367 protein AWQ21_00780 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AWQ21_00790 ENOG4105EY5 This is one of the two reaction center proteins of photosystem II AWQ21_00795 ENOG4107SC1 transglycosylase AWQ21_00840 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AWQ21_00850 ENOG4105NXP Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis (By similarity) AWQ21_00860 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AWQ21_00865 ENOG4105JZI cytochrome P450 AWQ21_00870 ENOG4105DUM transcriptional regulator, lysR family AWQ21_00875 ENOG4105D65 subunit l AWQ21_00880 ENOG4105C8S subunit m AWQ21_00890 ENOG410906A Beta-Ig-H3 fasciclin AWQ21_00895 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AWQ21_00900 ENOG4105C5R Aminotransferase AWQ21_00905 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AWQ21_00935 ENOG4107TVC Glycosyl transferase, family 2 AWQ21_00950 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AWQ21_00960 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AWQ21_00975 ENOG4108IAB Phoh family AWQ21_00985 ENOG4105CQM Urea amidohydrolase subunit alpha AWQ21_00990 ENOG4105C45 hydrogenase expression formation protein (HypE) AWQ21_01000 ENOG4107QIZ NADH dehydrogenase AWQ21_01035 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) AWQ21_01060 ENOG4105CQS hydrogenase expression formation protein HypD AWQ21_01075 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AWQ21_01110 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AWQ21_01120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWQ21_01130 ENOG4105W5Q DNA repair protein (RadC AWQ21_01140 ENOG4105CMS peptidase U62, modulator of DNA gyrase AWQ21_01170 ENOG4107SP2 The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity AWQ21_01175 ENOG4105NT3 This b-type cytochrome is tightly associated with the reaction center of photosystem II and possibly is part of the water-oxidation complex (By similarity) AWQ21_01185 ENOG4105JKW Valine--pyruvate aminotransferase AWQ21_01195 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AWQ21_01210 ENOG4105CJ1 ABC, transporter AWQ21_01235 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AWQ21_01285 ENOG4105D3Q Sugar transferase AWQ21_01290 ENOG41080FP Hydrolase AWQ21_01305 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AWQ21_01315 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AWQ21_01320 ENOG4105MS2 ribosomal subunit Interface protein AWQ21_01330 ENOG4107QVP Dehydrogenase AWQ21_01340 ENOG4108IPT Naphthoate synthase AWQ21_01345 ENOG4105CPJ photosystem II manganese-stabilizing AWQ21_01350 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AWQ21_01360 ENOG4105CIK Amidinotransferase AWQ21_01365 ENOG4105VFU Rna-binding protein AWQ21_01370 ENOG4105CJW magnesium transporter AWQ21_01400 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AWQ21_01410 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AWQ21_01445 ENOG4105D52 delta-aminolevulinic acid dehydratase AWQ21_01450 ENOG4105EUJ GTP cyclohydrolase i AWQ21_01460 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AWQ21_01475 ENOG4105EHU Circadian clock protein KaiC AWQ21_01480 ENOG4108ZGN Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC (By similarity) AWQ21_01485 ENOG4108WXF Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of KaiC. In contrast, the presence of KaiB in the complex decreases the phosphorylation status of KaiC, suggesting that KaiB acts by antagonizing the interaction between KaiA and KaiC. A KaiA dimer is sufficient to enhance KaiC hexamer phosphorylation AWQ21_01490 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AWQ21_01500 ENOG4105CHM Aminotransferase AWQ21_01515 ENOG4105BZU Histidine kinase AWQ21_01520 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AWQ21_01545 ENOG4108IYU L-aspartate oxidase AWQ21_01555 ENOG4105J0C AWQ21_01570 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AWQ21_01580 ENOG410642E Short chain dehydrogenase AWQ21_01585 ENOG4107QSQ Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AWQ21_01595 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AWQ21_01620 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AWQ21_01625 ENOG4107QPR SAICAR synthetase AWQ21_01630 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AWQ21_01635 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AWQ21_01640 ENOG4105D3R alkyl hydroperoxide reductase AWQ21_01645 ENOG41060KK Stabilizes the structure of photosystem II oxygen- evolving complex (OEC), the ion environment of oxygen evolution and protects the OEC against heat-induced inactivation (By similarity) AWQ21_01685 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AWQ21_01700 ENOG4105MRD Phage derived protein Gp49-like (DUF891) AWQ21_01725 ENOG4107T9Q phosphonate abc transporter AWQ21_01735 ENOG4105EYW Ion transport protein AWQ21_01745 ENOG4108JQB penicillin-binding protein 1C AWQ21_01755 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AWQ21_01775 ENOG4105CXB phosphoribosylaminoimidazole synthetase AWQ21_01785 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AWQ21_01805 ENOG4105XEV csbD-like AWQ21_01810 ENOG4105XEV csbD-like AWQ21_01820 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AWQ21_01835 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AWQ21_01840 ENOG4107RAQ aminopeptidase AWQ21_01845 ENOG4108JYK Dehydrogenase AWQ21_01850 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AWQ21_01860 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) AWQ21_01895 ENOG4105C0P Mg chelatase subunit ChlI AWQ21_01905 ENOG4108KGH TRANSCRIPTIONal AWQ21_01915 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AWQ21_01935 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AWQ21_01950 ENOG4107SGM protein serine threonine phosphatase AWQ21_01955 ENOG4105K64 Glycosyl transferase, family 2 AWQ21_01960 ENOG4105BZ4 penicillin-binding protein AWQ21_01965 ENOG4108807 Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. PetG is required for either the stability or assembly of the cytochrome b6-f complex (By similarity) AWQ21_02005 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AWQ21_02010 ENOG41082AN stage II sporulation protein AWQ21_02015 ENOG4108420 Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) AWQ21_02030 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit AWQ21_02045 ENOG41072GX Peptidase M22 Glycoprotease AWQ21_02050 ENOG41082AF Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AWQ21_02060 ENOG4105DEF Extracellular solute-binding protein, family 5 AWQ21_02070 ENOG4105C0Z ABC transporter AWQ21_02080 ENOG4105C32 Amino acid ABC transporter (Permease) AWQ21_02100 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AWQ21_02115 ENOG4108I69 Glycosyl transferases group 1 AWQ21_02120 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AWQ21_02125 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AWQ21_02130 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AWQ21_02135 ENOG4105C1B dTDP-glucose 4-6-dehydratase AWQ21_02145 ENOG4105H63 Glycosyl transferase, family 2 AWQ21_02155 ENOG4108UT6 Transferase hexapeptide repeat containing protein AWQ21_02160 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AWQ21_02175 ENOG4105EY8 ABC transporter AWQ21_02190 ENOG4105C9M aspartyl-trna synthetase AWQ21_02195 ENOG4108K9Q Controls heterocyst differentiation. Has both a protease and a DNA-binding activity (By similarity) AWQ21_02210 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AWQ21_02220 ENOG4105BZU Histidine kinase AWQ21_02230 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AWQ21_02245 ENOG4105CVR type I restriction-modification system AWQ21_02265 ENOG4107QTH restriction modification system DNA specificity domain AWQ21_02280 ENOG4107SCJ type I restriction enzyme EcoKI subunit R AWQ21_02285 ENOG4105DGW oligopeptidase A AWQ21_02290 ENOG4105CD8 aminopeptidase N AWQ21_02330 ENOG41082BG Binds together with S18 to 16S ribosomal RNA (By similarity) AWQ21_02340 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AWQ21_02350 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AWQ21_02365 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AWQ21_02375 ENOG4105BZU Histidine kinase AWQ21_02380 ENOG4105DSB aldose 1-epimerase AWQ21_02385 ENOG4108ZF3 Phosphatase AWQ21_02400 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AWQ21_02410 ENOG4107S5T Carbohydrate kinase AWQ21_02445 ENOG4105FFC UPF0187 protein AWQ21_02490 ENOG4105DX0 Hemolysin A AWQ21_02500 ENOG4105C1V Peptidase, M16 AWQ21_02525 ENOG4105DB7 PHP domain protein AWQ21_02530 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase AWQ21_02535 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AWQ21_02570 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AWQ21_02615 ENOG4105CVN desaturase AWQ21_02625 ENOG41081F0 Precorrin-8x methylmutase AWQ21_02635 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AWQ21_02640 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AWQ21_02650 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AWQ21_02655 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AWQ21_02665 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AWQ21_02670 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AWQ21_02680 ENOG41082B1 30S ribosomal protein S16 AWQ21_02690 ENOG4107RAJ Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AWQ21_02710 ENOG4107XW6 Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AWQ21_02720 ENOG4105CIH Imidazole acetol-phosphate transaminase AWQ21_02755 ENOG41090HT Inherit from COG: transposase AWQ21_02800 ENOG4105E5Z arginine transporter ATP-binding subunit AWQ21_02805 ENOG4105EEX Two component transcriptional regulator (Winged helix family AWQ21_02815 ENOG4105YB8 TM2 domain containing protein AWQ21_02825 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AWQ21_02835 ENOG41082FX This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AWQ21_02840 ENOG4105K46 50S ribosomal protein l27 AWQ21_02855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWQ21_02860 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AWQ21_02895 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) AWQ21_02900 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AWQ21_02905 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AWQ21_02925 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AWQ21_02940 ENOG41060PQ electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) AWQ21_02950 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AWQ21_02960 ENOG4105CVB Vitamin K epoxide reductase AWQ21_02965 ENOG4105EPU Molybdenum cofactor synthesis domain protein AWQ21_02980 ENOG4105GHY electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) AWQ21_03025 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AWQ21_03030 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AWQ21_03085 ENOG41085FC arsR family transcriptional regulator AWQ21_03090 ENOG4105ENT Efflux transporter rnd family, mfp subunit AWQ21_03095 ENOG4105DZP Membrane-associated zinc metalloprotease AWQ21_03110 ENOG4105CP7 Triose-phosphate isomerase AWQ21_03125 ENOG4105FIK Inherit from COG: dihydropteroate synthase AWQ21_03130 ENOG4105C75 arginyL-tRNA synthetase AWQ21_03140 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AWQ21_03165 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AWQ21_03185 ENOG4108DJF Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AWQ21_03190 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AWQ21_03200 ENOG4105C0D helicase AWQ21_03205 ENOG4105WXN Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AWQ21_03230 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) AWQ21_03235 ENOG4107WMZ Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AWQ21_03240 ENOG410811H Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) AWQ21_03265 ENOG4105C5H ABC transporter AWQ21_03295 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) AWQ21_03310 ENOG4105D05 Receptor AWQ21_03315 ENOG4105CPF Cell wall formation (By similarity) AWQ21_03335 ENOG4105D44 asparaginase AWQ21_03340 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AWQ21_03350 ENOG4105BZ1 (ABC) transporter AWQ21_03365 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AWQ21_03370 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AWQ21_03385 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AWQ21_03400 ENOG4106BTU phycobilisome rod-core linker polypeptide AWQ21_03410 ENOG410686T photosystem II reaction center protein N AWQ21_03415 ENOG4105WIA photosystem II reaction center protein H AWQ21_03435 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AWQ21_03440 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AWQ21_03460 ENOG4105BZU Histidine kinase AWQ21_03470 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AWQ21_03480 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AWQ21_03485 ENOG4105CFG Acts as a chaperone (By similarity) AWQ21_03490 ENOG4107Z9D Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AWQ21_03495 ENOG4107QHF type ii secretion system protein e AWQ21_03500 ENOG4105CZX twitching motility protein AWQ21_03530 ENOG4107TTQ Alpha beta hydrolase fold AWQ21_03540 ENOG4105ECY inositol monophosphatase AWQ21_03570 ENOG4105CQB FAD linked oxidase domain protein AWQ21_03575 ENOG4105BZ1 (ABC) transporter AWQ21_03585 ENOG4105EUK rtx toxin RtxA AWQ21_03590 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AWQ21_03595 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AWQ21_03605 ENOG4108KMV Glycosyl transferase (Group 1 AWQ21_03615 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) AWQ21_03665 ENOG4108R9R May be involved in photosynthetic membrane biogenesis (By similarity) AWQ21_03670 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AWQ21_03675 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AWQ21_03680 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AWQ21_03685 ENOG4105VYJ F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AWQ21_03690 ENOG4105S30 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AWQ21_03695 ENOG4105VH4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AWQ21_03700 ENOG4107SM1 it plays a direct role in the translocation of protons across the membrane (By similarity) AWQ21_03705 ENOG4105PA3 atp synthase AWQ21_03725 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AWQ21_03750 ENOG4107YBR Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AWQ21_03755 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AWQ21_03760 ENOG410823V Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AWQ21_03765 ENOG4105KAN Probably a ribosomal protein or a ribosome-associated protein (By similarity) AWQ21_03770 ENOG4107ZR3 Required for maturation of 30S ribosomal subunits (By similarity) AWQ21_03775 ENOG4105CHV Transcription elongation factor NusA AWQ21_03785 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AWQ21_03790 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AWQ21_03795 ENOG4107XHR Involved in DNA repair and RecF pathway recombination (By similarity) AWQ21_03805 ENOG4105S7S phosphonate abc transporter AWQ21_03810 ENOG4106AG1 Involved in the binding and or turnover of quinones at the Q(B) site of Photosystem II (By similarity) AWQ21_03835 ENOG4105C5H ABC transporter AWQ21_03860 ENOG4108IUZ ABC transporter AWQ21_03870 ENOG4105CVM Molybdenum cofactor synthesis domain protein AWQ21_03925 ENOG4108PWY Carbohydrate-selective porin OprB AWQ21_03940 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AWQ21_03950 ENOG4105C3J Cysteine desulfurase AWQ21_03960 ENOG4105DXN mazG family AWQ21_03975 ENOG4105CAY ferredoxin--nadp reductase AWQ21_04030 ENOG4108ISE 4Fe-4S ferredoxin, iron-sulfur binding AWQ21_04040 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AWQ21_04060 ENOG4105QVC MOSC domain-containing protein AWQ21_04080 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AWQ21_04095 ENOG4108IQE Amp-dependent synthetase and ligase AWQ21_04110 ENOG4105E0X reductase AWQ21_04140 ENOG4107TV7 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AWQ21_04165 ENOG4105C01 Dihydroxy-acid dehydratase AWQ21_04170 ENOG4106A2Z transcriptional regulator antitoxin, MazE AWQ21_04175 ENOG4105MZG transcriptional modulator of maze toxin, mazf AWQ21_04180 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AWQ21_04210 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) AWQ21_04230 ENOG4106BTU phycobilisome rod-core linker polypeptide AWQ21_04235 ENOG4105D9P serine threonine protein kinase AWQ21_04240 ENOG4108V5V Serine Threonine protein kinase AWQ21_04250 ENOG4105C26 Dehydrogenase AWQ21_04275 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AWQ21_04280 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AWQ21_04285 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AWQ21_04290 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AWQ21_04295 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AWQ21_04300 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AWQ21_04305 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AWQ21_04310 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AWQ21_04315 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AWQ21_04320 ENOG410848H 50s ribosomal protein l29 AWQ21_04325 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AWQ21_04330 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AWQ21_04335 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AWQ21_04340 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AWQ21_04345 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AWQ21_04350 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AWQ21_04355 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AWQ21_04360 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AWQ21_04365 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AWQ21_04375 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AWQ21_04385 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AWQ21_04390 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AWQ21_04395 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AWQ21_04400 ENOG4108ZT0 50S ribosomal protein l17 AWQ21_04405 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AWQ21_04410 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AWQ21_04415 ENOG4108UJD 30S ribosomal protein S9 AWQ21_04420 ENOG41082HT Binds the 23S rRNA (By similarity) AWQ21_04425 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AWQ21_04440 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AWQ21_04460 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AWQ21_04465 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AWQ21_04470 ENOG4107Z3D 50S ribosomal protein l10 AWQ21_04475 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AWQ21_04480 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AWQ21_04485 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AWQ21_04495 ENOG4105CV1 Transketolase (EC 2.2.1.1) AWQ21_04525 ENOG4105CTK cobaltochelatase, cobn subunit AWQ21_04565 ENOG4105Q36 FHA domain containing protein AWQ21_04600 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AWQ21_04625 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AWQ21_04635 ENOG4105CTK cobaltochelatase, cobn subunit AWQ21_04640 ENOG4105E4F Isochorismate synthase AWQ21_04645 ENOG4105VXP Protein of unknown function DUF86 AWQ21_04665 ENOG4105BZU Histidine kinase AWQ21_04680 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AWQ21_04705 ENOG41082ZZ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AWQ21_04715 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AWQ21_04720 ENOG4105W8H transhydrogenase (subunit alpha AWQ21_04725 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AWQ21_04735 ENOG4106E83 A core subunit of photosystem II (PSII) (By similarity) AWQ21_04740 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AWQ21_04745 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWQ21_04810 ENOG4105C89 phosphohexose isomerase AWQ21_04840 ENOG4106F7P Seems to play a role in the dimerization of PSII (By similarity) AWQ21_04845 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AWQ21_04850 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AWQ21_04865 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AWQ21_04895 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AWQ21_04915 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AWQ21_04925 ENOG4106FN3 tellurium resistance protein AWQ21_04930 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AWQ21_04940 ENOG4105BZU Histidine kinase AWQ21_04950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWQ21_04965 ENOG4107Y1F Involved in the transcription termination process (By similarity) AWQ21_04975 ENOG4105D7V transposase AWQ21_04990 ENOG4105Q36 FHA domain containing protein AWQ21_04995 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AWQ21_05000 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AWQ21_05020 ENOG4107QI6 Cysteine desulfurase AWQ21_05025 ENOG4108ZGN Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC (By similarity) AWQ21_05030 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWQ21_05075 ENOG4105C19 ABC transporter AWQ21_05080 ENOG41080ZE Adenylate cyclase AWQ21_05090 ENOG4105KHC sulfurtransferase AWQ21_05095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWQ21_05100 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase AWQ21_05110 ENOG4107YD0 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AWQ21_05125 ENOG4105BZU Histidine kinase AWQ21_05135 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase AWQ21_05140 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AWQ21_05170 ENOG4105CMV Succinyl-CoA synthetase subunit beta AWQ21_05175 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AWQ21_05180 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AWQ21_05185 ENOG4107STW synthase AWQ21_05190 ENOG4106N16 had-superfamily hydrolase, subfamily iib AWQ21_05200 ENOG4107QW3 Sucrose phosphorylase AWQ21_05205 ENOG4105CXT aspartate transcarbamylase AWQ21_05215 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AWQ21_05220 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AWQ21_05240 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AWQ21_05275 ENOG4107WDG serine threonine protein kinase AWQ21_05280 ENOG4108UGD Serine Threonine protein kinase AWQ21_05295 ENOG4107WDG serine threonine protein kinase AWQ21_05305 ENOG4107QPD alcohol dehydrogenase AWQ21_05310 ENOG4105BZU Histidine kinase AWQ21_05330 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) AWQ21_05335 ENOG4105D7T ABC transporter AWQ21_05345 ENOG4105I5W Transporter AWQ21_05350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWQ21_05355 ENOG4105DZ0 fad dependent oxidoreductase AWQ21_05370 ENOG4105D65 subunit l AWQ21_05375 ENOG4107SC0 ferredoxin--NADP reductase AWQ21_05380 ENOG4105G5N sensor protein AWQ21_05385 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWQ21_05390 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AWQ21_05410 ENOG41083EU 50s ribosomal protein l28 AWQ21_05425 ENOG4105CN1 protease AWQ21_05430 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AWQ21_05435 ENOG4108R6B Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AWQ21_05455 ENOG41086B8 CoB-CoM heterodisulfide reductase AWQ21_05460 ENOG4105BZU Histidine kinase AWQ21_05465 ENOG4107WJM -acetyltransferase AWQ21_05475 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AWQ21_05520 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AWQ21_05535 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AWQ21_05575 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AWQ21_05585 ENOG4105BZU Histidine kinase AWQ21_05600 ENOG4108UXN response regulator AWQ21_05630 ENOG4105CBS Chea signal transduction histidine kinase AWQ21_05685 ENOG4108S5W Seems to be required for the assembly of the photosystem I complex (By similarity) AWQ21_05710 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) AWQ21_05715 ENOG4106MP8 UPF0754 membrane protein AWQ21_05740 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AWQ21_05755 ENOG4105M0M Tetracycline resistance protein AWQ21_05800 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AWQ21_05805 ENOG4105C09 Bile acid AWQ21_05810 ENOG4107RJ1 sodium solute AWQ21_05815 ENOG4108USA electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) AWQ21_05830 ENOG4105D49 3-dehydroquinate synthase AWQ21_05890 ENOG410667J hydrolase AWQ21_05895 ENOG4105CXN decarboxylase AWQ21_05900 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AWQ21_05925 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AWQ21_05945 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AWQ21_05950 ENOG41089TF bicarbonate transport system substrate-binding protein AWQ21_05955 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AWQ21_05960 ENOG4107EEY synthase AWQ21_05970 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AWQ21_05975 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AWQ21_05980 ENOG4105D8X mechanosensitive ion channel AWQ21_05985 ENOG4107GBW cellulosome anchoring protein cohesin AWQ21_06000 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AWQ21_06050 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AWQ21_06080 ENOG4108YZ9 Urea amidohydrolase subunit gamma AWQ21_06110 ENOG4107R3J Transporter AWQ21_06115 ENOG4105MSA Photosystem II reaction center W protein AWQ21_06125 ENOG4105DHP deoxycytidine triphosphate deaminase AWQ21_06135 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWQ21_06155 ENOG4108Z03 MAF-like protein AWQ21_06165 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AWQ21_06170 ENOG4105CBT Fructose-1,6-bisphosphatase AWQ21_06215 ENOG41084GC stage II sporulation protein AWQ21_06230 ENOG4108YZA Nitrogen regulatory protein pii AWQ21_06235 ENOG4105WGP Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis (By similarity) AWQ21_06250 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AWQ21_06265 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AWQ21_06280 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AWQ21_06290 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AWQ21_06305 ENOG4105CDU Replicative dna helicase AWQ21_06305 ENOG4105CDU Replicative dna helicase AWQ21_06310 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AWQ21_06315 ENOG4105E66 phosphoriboisomerase A AWQ21_06355 ENOG4105BZU Histidine kinase AWQ21_06365 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AWQ21_06375 ENOG4105MSA Photosystem II reaction center W protein AWQ21_06385 ENOG4105C6E dna polymerase iii AWQ21_06390 ENOG4105DRS transport system, permease AWQ21_06395 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AWQ21_06415 ENOG4105CEY Amp-dependent synthetase and ligase AWQ21_06430 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AWQ21_06440 ENOG41080P6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AWQ21_06480 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) AWQ21_06600 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AWQ21_06610 ENOG4105CZX twitching motility protein AWQ21_06620 ENOG4105C37 (CBS) domain AWQ21_06655 ENOG4107QSS Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity) AWQ21_06660 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AWQ21_06670 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AWQ21_06690 ENOG4105K63 Thioredoxin AWQ21_06695 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AWQ21_06700 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AWQ21_06705 ENOG41084IE Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AWQ21_06710 ENOG4108DIF synthase (EC 4.2.1.75) AWQ21_06720 ENOG4105CFP Peptidase U32 AWQ21_06725 ENOG4107SKI cobyrinic Acid a,c-diamide synthase AWQ21_06770 ENOG41080XM UPF0145 protein AWQ21_06810 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AWQ21_06820 ENOG4107RIQ Sulfate adenylate transferase AWQ21_06840 ENOG4105DK0 Indole-3-glycerol phosphate synthase AWQ21_06855 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AWQ21_06865 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AWQ21_06870 ENOG4105BZU Histidine kinase AWQ21_06880 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AWQ21_06905 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AWQ21_06910 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AWQ21_06915 ENOG4105BZU Histidine kinase AWQ21_06945 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AWQ21_06950 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AWQ21_06960 ENOG4105C8Q Methyl-accepting chemotaxis AWQ21_06975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWQ21_06985 ENOG4108QDE fad dependent oxidoreductase AWQ21_07005 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component AWQ21_07010 ENOG4105BZU Histidine kinase AWQ21_07020 ENOG4105BZU Histidine kinase AWQ21_07050 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AWQ21_07060 ENOG4108TNP AWQ21_07065 ENOG4105WN2 Stabilizes the interaction between PsaC and the PSI core, assists the docking of the ferredoxin to PSI and interacts with ferredoxin-NADP oxidoreductase (By similarity) AWQ21_07070 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AWQ21_07105 ENOG4105C9X ppx gppa phosphatase AWQ21_07130 ENOG4105C12 Phosphoribosylglycinamide synthetase AWQ21_07170 ENOG41083MR nifu domain-containing protein AWQ21_07175 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AWQ21_07190 ENOG4105DF7 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) AWQ21_07195 ENOG4105EY5 This is one of the two reaction center proteins of photosystem II AWQ21_07210 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AWQ21_07220 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AWQ21_07300 ENOG4105C0Z ABC transporter AWQ21_07330 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) AWQ21_07335 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) AWQ21_07350 ENOG4107T8Q Glycosyl transferase (Group 1 AWQ21_07360 ENOG4105BZ1 (ABC) transporter AWQ21_07375 ENOG4105BZU Histidine kinase AWQ21_07380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWQ21_07385 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AWQ21_07395 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWQ21_07420 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AWQ21_07425 ENOG4105CW7 secretion protein, HlyD family AWQ21_07455 ENOG4108MIB AWQ21_07490 ENOG4105PNM synthesis protein AWQ21_07500 ENOG4108FN7 Aldo keto reductase AWQ21_07505 ENOG4108JUA Transcriptional regulator AWQ21_07510 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AWQ21_07570 ENOG4107KET secretion protein, HlyD family AWQ21_07575 ENOG4105CJ1 ABC, transporter AWQ21_07585 ENOG4107QWP ABC-2 type transporter AWQ21_07590 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AWQ21_07595 ENOG4105HHA aminodeoxychorismate lyase AWQ21_07610 ENOG4105CMR udp-glucose 4-epimerase AWQ21_07615 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AWQ21_07620 ENOG4107S2Z UPF0761 membrane protein AWQ21_07635 ENOG4105C8M UPF0272 protein AWQ21_07640 ENOG4107RTD sua5 ycio yrdc ywlc family protein AWQ21_07655 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AWQ21_07665 ENOG4105C6E dna polymerase iii AWQ21_07670 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AWQ21_07685 ENOG4108N0M stress protein AWQ21_07690 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AWQ21_07710 ENOG4105C8T Leucyl-tRNA synthetase AWQ21_07715 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) AWQ21_07725 ENOG4108ZAF Molybdopterin AWQ21_07730 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AWQ21_07815 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AWQ21_07820 ENOG4105CJN penicillin-binding protein AWQ21_07850 ENOG4105K63 Thioredoxin AWQ21_07860 ENOG4105C7B Threonine dehydratase AWQ21_07870 ENOG4108I0Q anthranilate phosphoribosyltransferase AWQ21_07880 ENOG4105DFE Dna adenine methylase AWQ21_07915 ENOG4108IV0 ABC, transporter AWQ21_07920 ENOG4105DGU Histone deacetylase AWQ21_07925 ENOG4105VFU Rna-binding protein AWQ21_07930 ENOG4105C5F glutamine synthetase AWQ21_07935 ENOG4108TCG allophycocyanin beta subunit AWQ21_07945 ENOG4107GBW cellulosome anchoring protein cohesin AWQ21_07950 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AWQ21_07960 ENOG4105JFG SpoIID LytB domain protein AWQ21_07965 ENOG4105CBS Chea signal transduction histidine kinase AWQ21_07970 ENOG4105CDY transcriptional regulatory protein AWQ21_07975 ENOG4108JA5 May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs (By similarity) AWQ21_07980 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AWQ21_07990 ENOG4105E4C Lytic transglycosylase catalytic AWQ21_08070 ENOG4105E0A ABC, transporter AWQ21_08080 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AWQ21_08090 ENOG4105EVY Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) AWQ21_08095 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AWQ21_08105 ENOG4107QP0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AWQ21_08190 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AWQ21_08200 ENOG4108R0D protein with myosin-like AWQ21_08205 ENOG4107RU9 Transcriptional regulator, Crp Fnr family AWQ21_08210 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AWQ21_08215 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AWQ21_08225 ENOG410600T transposase AWQ21_08230 ENOG4107QJE Chromosome Partitioning Protein AWQ21_08310 ENOG4108XAD Protein of unknown function (DUF1997) AWQ21_08315 ENOG41067UF AWQ21_08325 ENOG4105BZA Phosphoglycerate kinase AWQ21_08330 ENOG4105CPF Cell wall formation (By similarity) AWQ21_08335 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AWQ21_08355 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) AWQ21_08370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWQ21_08385 ENOG4105DJY efflux transporter, rnd family, mfp subunit AWQ21_08410 ENOG4105ERG peptidase m48, ste24p AWQ21_08425 ENOG4108PPB Seems to be required for the assembly of the photosystem I complex (By similarity) AWQ21_08430 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AWQ21_08440 ENOG4107Z8Z Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AWQ21_08445 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AWQ21_08450 ENOG4108YZT Adenosylcobinamide kinase AWQ21_08455 ENOG4105D6H One of the two reaction center proteins of photosystem II (PSII), D2 is needed for assembly of a stable PSII complex (By similarity) AWQ21_08485 ENOG4105DEF Extracellular solute-binding protein, family 5 AWQ21_08505 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase AWQ21_08510 ENOG4105BZU Histidine kinase AWQ21_08535 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AWQ21_08565 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component AWQ21_08570 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component AWQ21_08575 ENOG4105EPJ extracellular solute-binding protein family 1 AWQ21_08590 ENOG4108IJ0 Aspartate ammonia-lyase AWQ21_08595 ENOG4105BZU Histidine kinase AWQ21_08605 ENOG4105C0Z ABC transporter AWQ21_08610 ENOG4108IV0 ABC, transporter AWQ21_08615 ENOG4108ZJ4 polysaccharide deacetylase AWQ21_08655 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AWQ21_08665 ENOG4108VPT UPF0234 protein AWQ21_08685 ENOG4107RCI amp-dependent synthetase and ligase AWQ21_08695 ENOG4107RCI amp-dependent synthetase and ligase AWQ21_08705 ENOG4108S55 polysaccharide biosynthesis protein AWQ21_08715 ENOG4105C8S subunit m AWQ21_08725 ENOG4105EMN RNA polymerase sigma factor AWQ21_08735 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AWQ21_08750 ENOG4105K70 DNA-binding protein AWQ21_08755 ENOG4105C02 permease AWQ21_08765 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 AWQ21_08770 ENOG4105MN0 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 AWQ21_08775 ENOG4105CE9 30S ribosomal protein S2 AWQ21_08780 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AWQ21_08785 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AWQ21_08790 ENOG4105WH1 Two component transcriptional regulator luxr family AWQ21_08805 ENOG4108JA5 May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs (By similarity) AWQ21_08810 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 AWQ21_08835 ENOG4108UV1 cellular component movement AWQ21_08895 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AWQ21_08920 ENOG41081XQ Conserved Protein AWQ21_08925 ENOG4108MAQ allophycocyanin alpha AWQ21_08930 ENOG4105FBM allophycocyanin beta subunit AWQ21_08935 ENOG4105W5K Rod linker protein, associated with allophycocyanin. Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer (By similarity) AWQ21_08955 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AWQ21_08965 ENOG4105CRE cytochrome C AWQ21_08970 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) AWQ21_08980 ENOG41080W8 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) AWQ21_08995 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AWQ21_09025 ENOG4105D1D Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AWQ21_09030 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AWQ21_09045 ENOG4105F8J Adenylate Guanylate cyclase AWQ21_09050 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AWQ21_09055 ENOG4105DKP glycosyl transferase, family 9 AWQ21_09060 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AWQ21_09075 ENOG4105C9U ATP-dependent DNA helicase RecQ AWQ21_09085 ENOG4105N82 Endonuclease AWQ21_09095 ENOG4105IDI abc transporter atp-binding protein AWQ21_09100 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AWQ21_09110 ENOG41068G9 50S ribosomal protein L32 AWQ21_09125 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AWQ21_09135 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AWQ21_09140 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AWQ21_09155 ENOG4105IJJ transcriptional regulator, crp fnr family AWQ21_09160 ENOG4105CSR polyphosphate kinase 2 AWQ21_09235 ENOG4105KC4 UPF0296 protein AWQ21_09270 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AWQ21_09280 ENOG4105G5W regulator Fur family AWQ21_09285 ENOG4108N5B 2-phosphosulfolactate phosphatase AWQ21_09295 ENOG4107TS3 membrane protein, TerC AWQ21_09300 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AWQ21_09310 ENOG4107U7Q Transfers the fatty acyl group on membrane lipoproteins (By similarity) AWQ21_09315 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AWQ21_09320 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AWQ21_09335 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase AWQ21_09345 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AWQ21_09350 ENOG4108P5B Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) AWQ21_09365 ENOG4108IAJ Nad-dependent epimerase dehydratase AWQ21_09370 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AWQ21_09405 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) AWQ21_09415 ENOG4105C8S subunit m AWQ21_09420 ENOG4105D65 subunit l AWQ21_09430 ENOG4108WT6 Carbon dioxide concentrating mechanism protein AWQ21_09440 ENOG4105MXK Carbon dioxide concentrating mechanism protein AWQ21_09450 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate AWQ21_09475 ENOG4107QVI Methyltransferase, type 11 AWQ21_09505 ENOG4105PW4 Sugar fermentation stimulation protein homolog AWQ21_09515 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AWQ21_09520 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AWQ21_09565 ENOG41087BU transcriptional repressor DicA AWQ21_09650 ENOG4105EWK phytoene AWQ21_09660 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AWQ21_09670 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AWQ21_09680 ENOG4105DDQ anthranilate synthase AWQ21_09685 ENOG4107T8T UPF0173 metal-dependent hydrolase AWQ21_09710 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AWQ21_09725 ENOG4105D52 delta-aminolevulinic acid dehydratase AWQ21_09745 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AWQ21_09755 ENOG4107RSS Hydrogenase accessory protein HypB AWQ21_09780 ENOG4108K7V UPF0284 protein AWQ21_09785 ENOG410848W 30S ribosomal protein S21 AWQ21_09790 ENOG4107PU6 Membrane AWQ21_09795 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AWQ21_09800 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AWQ21_09830 ENOG4105E2X shikimate dehydrogenase AWQ21_09840 ENOG4105C3G gtp-binding protein AWQ21_09845 ENOG4105D9P serine threonine protein kinase AWQ21_09855 ENOG4108MXF Alpha Beta Hydrolase AWQ21_09880 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AWQ21_09895 ENOG4105CD5 CoA-binding domain protein AWQ21_09900 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AWQ21_09920 ENOG4107SWE Methyltransferase AWQ21_09925 ENOG4105EEK Polypeptide AWQ21_09945 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) AWQ21_09955 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AWQ21_09960 ENOG41085GJ domain protein AWQ21_09965 ENOG4105C8S subunit m AWQ21_09975 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AWQ21_09980 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AWQ21_09995 ENOG41084H8 Binds directly to 16S ribosomal RNA (By similarity) AWQ21_10000 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AWQ21_10020 ENOG4105QUE Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) AWQ21_10045 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AWQ21_10055 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AWQ21_10060 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AWQ21_10065 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AWQ21_10070 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AWQ21_10075 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AWQ21_10085 ENOG4105CJT Mannose-1-phosphate guanylyltransferase AWQ21_10090 ENOG4108Z6B deaminase AWQ21_10145 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AWQ21_10155 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) AWQ21_10160 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AWQ21_10165 ENOG4105C72 UPF0176 protein AWQ21_10170 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AWQ21_10175 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AWQ21_10180 ENOG4105BZU Histidine kinase AWQ21_10185 ENOG4107YJ4 chain length determinant protein AWQ21_10190 ENOG4105DAY polysaccharide export protein AWQ21_10260 ENOG4105EY8 ABC transporter AWQ21_10270 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AWQ21_10275 ENOG4107ZBH radical SAM domain protein AWQ21_10280 ENOG4105CPK Glycosyl transferase (Group 1 AWQ21_10330 ENOG4105CPK Glycosyl transferase (Group 1 AWQ21_10355 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AWQ21_10360 ENOG4107R0E Glycosyl transferase, family 2 AWQ21_10380 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) AWQ21_10385 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AWQ21_10395 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWQ21_10410 ENOG4105DFF Rod shape-determining protein mreb AWQ21_10435 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AWQ21_10450 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AWQ21_10515 ENOG4108PJD permease AWQ21_10520 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AWQ21_10555 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AWQ21_10565 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) AWQ21_10575 ENOG4107TE5 Lipid kinase AWQ21_10585 ENOG410902K Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AWQ21_10595 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AWQ21_10625 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AWQ21_10645 ENOG4105E0C molybdate abc transporter AWQ21_10660 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AWQ21_10670 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AWQ21_10675 ENOG4105X1F electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) AWQ21_10680 ENOG4108SMZ Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) AWQ21_10690 ENOG4105EKE dihydroorotase AWQ21_10695 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AWQ21_10700 ENOG4105C32 Amino acid ABC transporter (Permease) AWQ21_10705 ENOG4105EB3 Histidine kinase AWQ21_10715 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AWQ21_10720 ENOG4105C4R Atp-dependent dna helicase AWQ21_10730 ENOG4108IUW ABC transporter AWQ21_10735 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AWQ21_10750 ENOG4105EMN RNA polymerase sigma factor AWQ21_10780 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AWQ21_10790 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AWQ21_10800 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AWQ21_10860 ENOG4108S1Y allophycocyanin alpha-B chain AWQ21_10890 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AWQ21_10895 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWQ21_10900 ENOG4107U45 Cobalt transport protein AWQ21_10910 ENOG41069TS Photosystem II reaction center protein M AWQ21_10945 ENOG4105D7V transposase AWQ21_10970 ENOG4105D64 Mechanosensitive ion channel AWQ21_10975 ENOG4108QF0 This is one of the two reaction center proteins of photosystem II AWQ21_11045 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AWQ21_11050 ENOG41084A0 50s ribosomal protein L35 AWQ21_11070 ENOG4105CKK Glycosyl transferase, family 2 AWQ21_11085 ENOG4105CHM Aminotransferase AWQ21_11090 ENOG4105BZ1 (ABC) transporter AWQ21_11095 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AWQ21_11110 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AWQ21_11115 ENOG4105CNI cell division protein FtsW AWQ21_11120 ENOG4105CXI aluminum resistance protein AWQ21_11130 ENOG4105D6H One of the two reaction center proteins of photosystem II (PSII), D2 is needed for assembly of a stable PSII complex (By similarity) AWQ21_11150 ENOG4108I0Q anthranilate phosphoribosyltransferase AWQ21_11165 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AWQ21_11180 ENOG4105D6V phycocyanin beta subunit AWQ21_11185 ENOG4108SDR phycocyanin, alpha subunit AWQ21_11190 ENOG4108MZQ phycobilisome linker polypeptide AWQ21_11195 ENOG41065ZC Rod linker protein, associated with phycocyanin. Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer AWQ21_11200 ENOG41078GB pbs lyase AWQ21_11205 ENOG4108V9J phycocyanobilin lyase AWQ21_11210 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 AWQ21_11235 ENOG4107YU2 histidine triad (hIT) protein AWQ21_11245 ENOG4105DA5 (ABC) transporter AWQ21_11270 ENOG4105E67 Catalyzes the four-electron reduction of biliverdin IX- alpha (2-electron reduction at both the A and D rings) AWQ21_11275 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AWQ21_11280 ENOG4105CJ1 ABC, transporter AWQ21_11295 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AWQ21_11325 ENOG4107QJE Chromosome Partitioning Protein AWQ21_11385 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AWQ21_11420 ENOG4105EYH Exonuclease AWQ21_11445 ENOG410902C phosphohistidine phosphatase, SixA AWQ21_11455 ENOG4108W6I photosystem I reaction center protein subunit XI AWQ21_11475 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AWQ21_11495 ENOG4105C59 p-type ATPase AWQ21_11520 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) AWQ21_11540 ENOG4105M3Z response regulator AWQ21_11555 ENOG4105CBS Chea signal transduction histidine kinase AWQ21_11560 ENOG4105DVC DnaJ domain protein AWQ21_11570 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AWQ21_11580 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AWQ21_11585 ENOG4105BZU Histidine kinase AWQ21_11600 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AWQ21_11620 ENOG4105DN3 alpha-2-macroglobulin domain protein AWQ21_11625 ENOG4105CD2 stage iii sporulation protein aa AWQ21_11650 ENOG4105CNN ABC, transporter AWQ21_11655 ENOG4105C0K Gdp-mannose 4,6-dehydratase AWQ21_11660 ENOG4107YCR Transcriptional regulator, ARSR family AWQ21_11675 ENOG4105CVJ phosphoglycerate mutase AWQ21_11730 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AWQ21_11740 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AWQ21_11750 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AWQ21_11765 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AWQ21_11770 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AWQ21_11800 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AWQ21_11810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWQ21_11840 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AWQ21_11845 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AWQ21_11855 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AWQ21_11860 ENOG4105CEV competence damage-inducible protein AWQ21_11870 ENOG4105WH1 Two component transcriptional regulator luxr family AWQ21_11875 ENOG4105NZG Ferredoxin AWQ21_11900 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AWQ21_11905 ENOG4105CAS nag kinase AWQ21_11910 ENOG4105E0Y RtcB Protein AWQ21_11950 ENOG4107RY6 amino acid AWQ21_11970 ENOG4105BZU Histidine kinase AWQ21_11975 ENOG41067UF AWQ21_11985 ENOG4105NXV High-affinity zinc uptake system protein AWQ21_11990 ENOG4105DIK (ABC) transporter AWQ21_12005 ENOG4108Z0R Transferase AWQ21_12055 ENOG4105CH7 arginosuccinase AWQ21_12160 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AWQ21_12190 ENOG4105C5S asparaginyl-tRNA synthetase AWQ21_12210 ENOG4105C7Z Conserved Protein AWQ21_12230 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AWQ21_12250 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AWQ21_12255 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AWQ21_12285 ENOG4107T8Q Glycosyl transferase (Group 1 AWQ21_12295 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AWQ21_12310 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AWQ21_12320 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AWQ21_12325 ENOG4105HFZ Membrane AWQ21_12330 ENOG4105M4P Tetr family transcriptional regulator AWQ21_12340 ENOG4105DKQ ROK family AWQ21_12345 ENOG4105KI2 Urea amidohydrolase subunit beta AWQ21_12360 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AWQ21_12365 ENOG4105D3Q Sugar transferase AWQ21_12375 ENOG4105ESV Glycosyl transferase, family 4 AWQ21_12380 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AWQ21_12410 ENOG4105CHH sulfate transporter AWQ21_12420 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AWQ21_12425 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AWQ21_12455 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AWQ21_12470 ENOG4105CHF Glutathione S-transferase AWQ21_12495 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AWQ21_12505 ENOG4105D9M gamma-glutamylcysteine synthetase AWQ21_12510 ENOG4105CQC Prephenate dehydratase AWQ21_12535 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AWQ21_12545 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AWQ21_12560 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) AWQ21_12575 ENOG4105TQG cytochrome C, class I AWQ21_12580 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AWQ21_12655 ENOG4108JPZ Monovalent cation H antiporter subunit D AWQ21_12660 ENOG4108JPZ Monovalent cation H antiporter subunit D AWQ21_12665 ENOG4108ZE9 Monovalent cation H antiporter subunit C AWQ21_12675 ENOG4105CHH sulfate transporter AWQ21_12680 ENOG4105CA3 membrane-bound lytic murein transglycosylase AWQ21_12700 ENOG4105FQ6 thiopurine methyltransferase AWQ21_12705 ENOG4105BZU Histidine kinase AWQ21_12725 ENOG41089UC methyltransferase, type 11 AWQ21_12730 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AWQ21_12755 ENOG4105CBX hi0933 family AWQ21_12765 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AWQ21_12775 ENOG4105KRQ Addiction module toxin, Txe YoeB family AWQ21_12780 ENOG4105VTW prevent-host-death family AWQ21_12805 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AWQ21_12810 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) AWQ21_12820 ENOG4105C78 Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) AWQ21_12850 ENOG4105C6Y Udp-glucose 6-dehydrogenase AWQ21_12860 ENOG4105XCI PucC protein AWQ21_12865 ENOG41083KH UPF0102 protein AWQ21_12875 ENOG4108VAU general secretion pathway protein G AWQ21_12885 ENOG4105C9B Cysteine desulfurase AWQ21_12900 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AWQ21_12905 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AWQ21_12910 ENOG4105C8S subunit m AWQ21_12915 ENOG410811Q Ferredoxin AWQ21_12925 ENOG4105D9R oxidoreductase AWQ21_12950 ENOG4107STQ Multicopper oxidase AWQ21_12955 ENOG4105C59 p-type ATPase AWQ21_12990 ENOG4105CEP NADH dehydrogenase AWQ21_13005 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AWQ21_13040 ENOG4105CJN penicillin-binding protein AWQ21_13050 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein AWQ21_13060 ENOG4105KAF membrAne AWQ21_13075 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AWQ21_13090 ENOG4105K8N protein family UPF0079, ATPase AWQ21_13100 ENOG4105E2Z phosphate ABC transporter (Permease AWQ21_13105 ENOG4105C8U phosphate abc transporter AWQ21_13115 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AWQ21_13125 ENOG4105J3Z Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AWQ21_13130 ENOG4107YUH hydrolase AWQ21_13145 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AWQ21_13155 ENOG4105CUT histidyl-tRNA synthetase AWQ21_13175 ENOG4105BZU Histidine kinase AWQ21_13180 ENOG4108JQ6 ABC transporter AWQ21_13185 ENOG4108TJN glycosyl transferase group 1 AWQ21_13190 ENOG4105CZN Potassium uptake protein AWQ21_13195 ENOG4107ZYR domain protein AWQ21_13210 ENOG4108R6K riboflavin synthase, subunit alpha AWQ21_13260 ENOG4108HYG acetyltransferase AWQ21_13320 ENOG4106I2R Coenzyme F420 hydrogenase dehydrogenase, beta AWQ21_13360 ENOG4105BZU Histidine kinase AWQ21_13375 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AWQ21_13415 ENOG4105BZU Histidine kinase AWQ21_13420 ENOG4105CKI cobalamin synthesis protein AWQ21_13430 ENOG4108PWY Carbohydrate-selective porin OprB AWQ21_13435 ENOG4107E2E PKHD-type hydroxylase AWQ21_13475 ENOG4105CVP deoxyribo-dipyrimidine photolyase AWQ21_13480 ENOG4107R6F Alpha Beta Hydrolase Fold protein AWQ21_13515 ENOG4108HMN Caspase domain AWQ21_13560 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) AWQ21_13565 ENOG4105BZU Histidine kinase AWQ21_13570 ENOG4105BZU Histidine kinase AWQ21_13580 ENOG4105K5B UPF0225 protein AWQ21_13585 ENOG4105CEN a g-specific adenine glycosylase AWQ21_13600 ENOG4105D64 Mechanosensitive ion channel AWQ21_13615 ENOG4107WDG serine threonine protein kinase AWQ21_13645 ENOG4108JJB ABC transporter AWQ21_13650 ENOG4107Y82 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AWQ21_13655 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AWQ21_13670 ENOG4108IJ6 ABC transporter AWQ21_13685 ENOG4105JQN Transcriptional regulator AWQ21_13735 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AWQ21_13760 ENOG4108MUZ hydrolase AWQ21_13765 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AWQ21_13785 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AWQ21_13825 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AWQ21_13830 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AWQ21_13835 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AWQ21_13845 ENOG4108PWY Carbohydrate-selective porin OprB AWQ21_13900 ENOG4105BZU Histidine kinase AWQ21_13910 ENOG410848D S4 domain protein YaaA AWQ21_13920 ENOG410600T transposase AWQ21_13925 ENOG4108K5P (LipO)protein AWQ21_13935 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) AWQ21_13945 ENOG4105C7K acetolactate synthase AWQ21_13955 ENOG4108Y85 Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) AWQ21_13970 ENOG4105DCF alanine dehydrogenase AWQ21_13975 ENOG4107WNA Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AWQ21_13990 ENOG4105CYM Glutathione S-transferase AWQ21_14000 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AWQ21_14010 ENOG4107Z12 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) AWQ21_14045 ENOG4105BZ1 (ABC) transporter AWQ21_14050 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AWQ21_14075 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AWQ21_14095 ENOG4108MV2 Involved in light-induced Na( )-dependent proton extrusion. Also seems to be involved in CO(2) transport (By similarity) AWQ21_14105 ENOG4106855 Competence protein AWQ21_14110 ENOG4105WDY DNA (cytosine-5-)-methyltransferase AWQ21_14115 ENOG4105CDH Citrulline--aspartate ligase AWQ21_14120 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AWQ21_14135 ENOG4107CUI carotenoid binding protein AWQ21_14145 ENOG4105KZX Pterin carbinolamine dehydratase AWQ21_14150 ENOG4108PWY Carbohydrate-selective porin OprB AWQ21_14155 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AWQ21_14175 ENOG4108JA5 May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs (By similarity) AWQ21_14180 ENOG4107RFW hydrolase family 57 AWQ21_14190 ENOG41086DT Membrane protein of unknown function AWQ21_14195 ENOG4108IV0 ABC, transporter AWQ21_14220 ENOG4105CE4 GlcNAc 6-P deacetylase AWQ21_14265 ENOG4105D3G Pseudouridine synthase AWQ21_14290 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AWQ21_14330 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) AWQ21_14340 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase AWQ21_14350 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AWQ21_14355 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AWQ21_14360 ENOG410801B Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AWQ21_14370 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) AWQ21_14375 ENOG4105CQB FAD linked oxidase domain protein AWQ21_14405 ENOG4105CHW UPF0052 protein AWQ21_14410 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AWQ21_14420 ENOG4108VCT Sulfite exporter TauE/SafE AWQ21_14425 ENOG4105BZU Histidine kinase AWQ21_14440 ENOG4105CP2 von willebrand factor, type a AWQ21_14445 ENOG4105C8N cysteinyl-tRNA synthetase AWQ21_14455 ENOG4107QJE Chromosome Partitioning Protein AWQ21_14610 ENOG4105CVR type I restriction-modification system AWQ21_14625 ENOG4105EKX Restriction modification system DNA (Specificity AWQ21_14635 ENOG4105DZR Type I site-specific deoxyribonuclease AWQ21_14720 ENOG4105C8B TIGR00159 family AWQ21_14845 ENOG4108K5P (LipO)protein AWQ21_14880 ENOG4107R3N Filamentation induced by cAMP protein fic AWQ21_14915 ENOG4107QJE Chromosome Partitioning Protein AWQ21_14920 ENOG4105FA0 parb-like partition protein AWQ21_15065 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AWQ21_15090 ENOG4105WDY DNA (cytosine-5-)-methyltransferase AWQ21_15125 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A AWQ21_15130 ENOG4105XMH SpoVT AbrB domain protein AWQ21_15135 ENOG4105C0D helicase AWQ21_15260 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) AWQ21_15285 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AWQ21_15380 ENOG4108IJ6 ABC transporter AWQ21_15420 ENOG4105CKD glutathione-regulated potassium-efflux system protein AWQ21_15445 ENOG41086B8 CoB-CoM heterodisulfide reductase AWQ21_15450 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase AWQ21_15545 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AWQ21_15550 ENOG4107ENK receptor AWQ21_15555 ENOG4105E0A ABC, transporter AWQ21_15560 ENOG4105EHG Permease protein AWQ21_15570 ENOG4108UDB Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AWQ21_15625 ENOG4105YB8 TM2 domain containing protein AWQ21_15660 ENOG4105D5T phosphonate abc transporter AWQ21_15670 ENOG4105UHE Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AWQ21_15710 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AWQ21_15715 ENOG41067HS methyltransferase AWQ21_15720 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process AWQ21_15740 ENOG4105C5I Dehydrogenase