locus-tag	class	description
SynPROS71_00001	COG0592	DNA-directed DNA polymerase activity
SynPROS71_00003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynPROS71_00004	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynPROS71_00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynPROS71_00007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynPROS71_00010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynPROS71_00011	COG0552	protein localization to endoplasmic reticulum
SynPROS71_00012	COG2208	phosphoserine phosphatase activity
SynPROS71_00013	COG0165	Argininosuccinate lyase
SynPROS71_00014	COG0724	RNA recognition motif
SynPROS71_00015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynPROS71_00017	COG2081	HI0933 family
SynPROS71_00018	COG1459	type II secretion system
SynPROS71_00020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynPROS71_00021	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynPROS71_00022	COG0484	heat shock protein binding
SynPROS71_00024	COG1162	GTPase activity
SynPROS71_00025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynPROS71_00026	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynPROS71_00027	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynPROS71_00029	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynPROS71_00030	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynPROS71_00031	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynPROS71_00032	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynPROS71_00033	COG0511	ligase activity, forming carbon-carbon bonds
SynPROS71_00034	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynPROS71_00050	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynPROS71_00051	COG0519	Catalyzes the synthesis of GMP from XMP
SynPROS71_00051	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynPROS71_00054	COG0768	penicillin binding
SynPROS71_00055	COG0438	transferase activity, transferring glycosyl groups
SynPROS71_00058	COG2022	thiamine diphosphate biosynthetic process
SynPROS71_00061	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynPROS71_00062	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynPROS71_00063	COG2385	sporulation resulting in formation of a cellular spore
SynPROS71_00064	COG1215	transferase activity, transferring glycosyl groups
SynPROS71_00065	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynPROS71_00067	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynPROS71_00068	COG0740	serine-type endopeptidase activity
SynPROS71_00069	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynPROS71_00070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynPROS71_00071	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynPROS71_00072	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynPROS71_00074	COG0037	tRNA processing
SynPROS71_00078	COG0556	nucleotide-excision repair
SynPROS71_00081	COG0556	nucleotide-excision repair
SynPROS71_00083	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROS71_00084	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynPROS71_00092	COG2082	Precorrin-8x methylmutase
SynPROS71_00093	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynPROS71_00096	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynPROS71_00097	COG0556	nucleotide-excision repair
SynPROS71_00106	COG0436	Aminotransferase
SynPROS71_00108	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynPROS71_00120	COG1091	dTDP-4-dehydrorhamnose reductase activity
SynPROS71_00121	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynPROS71_00123	COG1088	dTDP-glucose 4,6-dehydratase activity
SynPROS71_00124	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynPROS71_00125	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynPROS71_00130	COG0438	transferase activity, transferring glycosyl groups
SynPROS71_00140	COG0438	transferase activity, transferring glycosyl groups
SynPROS71_00149	COG0438	transferase activity, transferring glycosyl groups
SynPROS71_00152	COG1216	Glycosyl transferase, family 2
SynPROS71_00154	COG0438	transferase activity, transferring glycosyl groups
SynPROS71_00161	COG0653	protein targeting
SynPROS71_00162	COG1045	serine acetyltransferase
SynPROS71_00163	COG1725	Transcriptional regulator
SynPROS71_00165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynPROS71_00166	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynPROS71_00167	COG1372	Participates in initiation and elongation during chromosome replication
SynPROS71_00167	COG0187	DNA topoisomerase II activity
SynPROS71_00169	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynPROS71_00170	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynPROS71_00171	COG0386	Belongs to the glutathione peroxidase family
SynPROS71_00172	COG2239	Acts as a magnesium transporter
SynPROS71_00173	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROS71_00188	COG1070	Carbohydrate kinase
SynPROS71_00190	COG0802	atpase or kinase
SynPROS71_00191	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynPROS71_00192	COG0586	Pfam SNARE associated Golgi protein
SynPROS71_00193	COG0629	single-stranded DNA binding
SynPROS71_00195	COG1792	Involved in formation and maintenance of cell shape
SynPROS71_00199	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynPROS71_00203	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynPROS71_00204	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynPROS71_00205	COG1357	PFAM Pentapeptide repeats (8 copies)
SynPROS71_00205	COG0515	serine threonine protein kinase
SynPROS71_00206	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynPROS71_00207	COG2255	four-way junction helicase activity
SynPROS71_00209	COG1473	amidohydrolase
SynPROS71_00212	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynPROS71_00216	COG0463	Glycosyl transferase, family 2
SynPROS71_00218	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynPROS71_00219	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynPROS71_00220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynPROS71_00221	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS71_00222	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynPROS71_00223	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynPROS71_00223	COG0662	Cupin 2, conserved barrel domain protein
SynPROS71_00224	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynPROS71_00226	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROS71_00227	COG0571	ribonuclease III activity
SynPROS71_00233	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SynPROS71_00234	COG0058	SHG alpha-glucan phosphorylase activity
SynPROS71_00235	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SynPROS71_00236	COG0475	glutathione-regulated potassium exporter activity
SynPROS71_00240	COG0277	FAD linked oxidase domain protein
SynPROS71_00242	COG0247	lactate metabolic process
SynPROS71_00243	COG0538	isocitrate dehydrogenase activity
SynPROS71_00244	COG0463	Glycosyl transferase, family 2
SynPROS71_00247	COG5398	heme oxygenase
SynPROS71_00250	COG0438	transferase activity, transferring glycosyl groups
SynPROS71_00252	COG0438	transferase activity, transferring glycosyl groups
SynPROS71_00253	COG0438	transferase activity, transferring glycosyl groups
SynPROS71_00257	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynPROS71_00259	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynPROS71_00260	COG0617	tRNA 3'-terminal CCA addition
SynPROS71_00262	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynPROS71_00266	COG0709	Synthesizes selenophosphate from selenide and ATP
SynPROS71_00267	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynPROS71_00274	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynPROS71_00276	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynPROS71_00277	COG1083	cytidylyl-transferase
SynPROS71_00280	COG2089	acid synthase
SynPROS71_00286	COG3959	Transketolase, thiamine diphosphate binding domain
SynPROS71_00287	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynPROS71_00303	COG0124	histidyl-tRNA synthetase
SynPROS71_00304	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynPROS71_00311	COG4447	cellulose binding
SynPROS71_00312	COG1773	rubredoxin
SynPROS71_00313	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS71_00314	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS71_00315	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS71_00316	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynPROS71_00318	COG3842	ATPase activity
SynPROS71_00320	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynPROS71_00320	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynPROS71_00322	COG0494	nUDIX hydrolase
SynPROS71_00323	COG0415	Belongs to the DNA photolyase family
SynPROS71_00324	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SynPROS71_00329	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynPROS71_00330	COG0131	Imidazoleglycerol-phosphate dehydratase
SynPROS71_00331	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynPROS71_00334	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynPROS71_00338	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynPROS71_00339	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynPROS71_00341	COG0354	folic acid binding
SynPROS71_00342	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynPROS71_00345	COG1253	flavin adenine dinucleotide binding
SynPROS71_00346	COG0673	inositol 2-dehydrogenase activity
SynPROS71_00350	COG0343	queuine tRNA-ribosyltransferase activity
SynPROS71_00351	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SynPROS71_00355	COG0138	bifunctional purine biosynthesis protein purh
SynPROS71_00358	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynPROS71_00359	COG0004	ammonium transporteR
SynPROS71_00361	COG1489	DNA binding
SynPROS71_00362	COG0728	peptidoglycan biosynthetic process
SynPROS71_00367	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynPROS71_00368	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynPROS71_00369	COG1546	Belongs to the CinA family
SynPROS71_00369	COG1058	Belongs to the CinA family
SynPROS71_00370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynPROS71_00371	COG0066	3-isopropylmalate dehydratase activity
SynPROS71_00379	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynPROS71_00380	COG0193	aminoacyl-tRNA hydrolase activity
SynPROS71_00384	COG4372	Transposase
SynPROS71_00385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROS71_00386	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynPROS71_00388	COG0717	Belongs to the dCTP deaminase family
SynPROS71_00390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynPROS71_00394	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynPROS71_00397	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynPROS71_00402	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynPROS71_00406	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynPROS71_00409	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynPROS71_00411	COG2094	Belongs to the DNA glycosylase MPG family
SynPROS71_00414	COG2094	Belongs to the DNA glycosylase MPG family
SynPROS71_00417	COG2274	protein secretion by the type I secretion system
SynPROS71_00426	COG2094	Belongs to the DNA glycosylase MPG family
SynPROS71_00427	COG0540	Belongs to the ATCase OTCase family
SynPROS71_00435	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynPROS71_00438	COG2046	Belongs to the sulfate adenylyltransferase family
SynPROS71_00438	COG0529	Catalyzes the synthesis of activated sulfate
SynPROS71_00439	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROS71_00440	COG0800	Aldolase
SynPROS71_00442	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynPROS71_00444	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynPROS71_00445	COG2226	methyltransferase
SynPROS71_00447	COG4175	Glycine betaine
SynPROS71_00448	COG4176	ABC-type proline glycine betaine transport system permease component
SynPROS71_00449	COG2113	Glycine betaine
SynPROS71_00450	COG0385	Bile acid
SynPROS71_00452	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynPROS71_00454	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynPROS71_00455	COG0436	Aminotransferase
SynPROS71_00457	COG1530	ribonuclease E activity
SynPROS71_00458	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynPROS71_00461	COG2226	methyltransferase
SynPROS71_00462	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynPROS71_00463	COG0051	transcription antitermination factor activity, RNA binding
SynPROS71_00464	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynPROS71_00465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynPROS71_00466	COG0049	tRNA binding
SynPROS71_00467	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynPROS71_00470	COG0067	glutamate synthase
SynPROS71_00470	COG0069	glutamate synthase activity
SynPROS71_00470	COG0070	glutamate synthase
SynPROS71_00476	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynPROS71_00481	COG2885	chlorophyll binding
SynPROS71_00482	COG2885	chlorophyll binding
SynPROS71_00489	COG0463	Glycosyl transferase, family 2
SynPROS71_00494	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynPROS71_00496	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynPROS71_00497	COG0254	rRNA binding
SynPROS71_00498	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynPROS71_00499	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynPROS71_00501	COG0101	tRNA pseudouridine synthase activity
SynPROS71_00502	COG0203	ribosomal protein L17
SynPROS71_00503	COG0202	RNA polymerase activity
SynPROS71_00504	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynPROS71_00505	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynPROS71_00506	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynPROS71_00507	COG0563	adenylate kinase activity
SynPROS71_00508	COG0201	protein transport
SynPROS71_00509	COG0200	Binds to the 23S rRNA
SynPROS71_00510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynPROS71_00511	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynPROS71_00512	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynPROS71_00513	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynPROS71_00514	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynPROS71_00515	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynPROS71_00516	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynPROS71_00517	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynPROS71_00518	COG0255	Belongs to the universal ribosomal protein uL29 family
SynPROS71_00519	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynPROS71_00520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynPROS71_00521	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynPROS71_00522	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynPROS71_00523	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynPROS71_00524	COG0089	rRNA binding
SynPROS71_00525	COG0088	Forms part of the polypeptide exit tunnel
SynPROS71_00526	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynPROS71_00529	COG3854	ATPases associated with a variety of cellular activities
SynPROS71_00532	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynPROS71_00536	COG0287	Prephenate dehydrogenase
SynPROS71_00538	COG3001	Fructosamine kinase
SynPROS71_00542	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynPROS71_00543	COG1606	tRNA processing
SynPROS71_00544	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynPROS71_00545	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynPROS71_00548	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynPROS71_00549	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynPROS71_00550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynPROS71_00552	COG5002	protein histidine kinase activity
SynPROS71_00553	COG0772	Belongs to the SEDS family
SynPROS71_00554	COG0489	protein tyrosine kinase activity
SynPROS71_00555	COG0408	coproporphyrinogen oxidase activity
SynPROS71_00565	COG0667	Aldo Keto reductase
SynPROS71_00567	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynPROS71_00569	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynPROS71_00570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynPROS71_00570	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynPROS71_00571	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynPROS71_00572	COG1413	lyase activity
SynPROS71_00595	COG0237	dephospho-CoA kinase activity
SynPROS71_00604	COG1070	Carbohydrate kinase
SynPROS71_00605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynPROS71_00606	COG0546	phosphoglycolate phosphatase activity
SynPROS71_00607	COG0539	negative regulation of cytoplasmic translation
SynPROS71_00608	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynPROS71_00612	COG0589	response to stress
SynPROS71_00615	COG2890	protein-(glutamine-N5) methyltransferase activity
SynPROS71_00616	COG0009	L-threonylcarbamoyladenylate synthase
SynPROS71_00621	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynPROS71_00622	COG2894	cell division
SynPROS71_00623	COG0850	regulation of cytokinetic process
SynPROS71_00624	COG1078	dGTPase activity
SynPROS71_00625	COG0793	Belongs to the peptidase S41A family
SynPROS71_00626	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynPROS71_00627	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynPROS71_00634	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynPROS71_00635	COG0235	Class ii aldolase
SynPROS71_00636	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynPROS71_00639	COG0514	ATP-dependent DNA helicase (RecQ)
SynPROS71_00640	COG1705	Flagellar rod assembly protein muramidase FlgJ
SynPROS71_00640	COG1388	LysM domain
SynPROS71_00641	COG1012	belongs to the aldehyde dehydrogenase family
SynPROS71_00643	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynPROS71_00644	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynPROS71_00648	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynPROS71_00653	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynPROS71_00657	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynPROS71_00660	COG1376	ErfK ybiS ycfS ynhG family protein
SynPROS71_00662	COG1160	GTP binding
SynPROS71_00663	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynPROS71_00665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynPROS71_00666	COG1799	cell septum assembly
SynPROS71_00667	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynPROS71_00668	COG0438	transferase activity, transferring glycosyl groups
SynPROS71_00670	COG1381	Involved in DNA repair and RecF pathway recombination
SynPROS71_00671	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynPROS71_00672	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynPROS71_00673	COG0321	lipoyl(octanoyl) transferase activity
SynPROS71_00674	COG1022	Amp-dependent synthetase and ligase
SynPROS71_00677	COG0531	amino acid
SynPROS71_00678	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynPROS71_00679	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynPROS71_00683	COG3239	Fatty acid desaturase
SynPROS71_00685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynPROS71_00688	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynPROS71_00699	COG1104	cysteine desulfurase activity
SynPROS71_00704	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynPROS71_00705	COG0579	oxidoreductase
SynPROS71_00708	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynPROS71_00711	COG2095	MarC family integral membrane protein
SynPROS71_00712	COG0181	hydroxymethylbilane synthase activity
SynPROS71_00718	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROS71_00719	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynPROS71_00721	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynPROS71_00724	COG0629	single-stranded DNA binding
SynPROS71_00726	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynPROS71_00727	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynPROS71_00729	COG0442	prolyl-tRNA aminoacylation
SynPROS71_00732	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynPROS71_00736	COG0681	Belongs to the peptidase S26 family
SynPROS71_00742	COG0768	penicillin binding
SynPROS71_00743	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynPROS71_00745	COG0415	Belongs to the DNA photolyase family
SynPROS71_00747	COG0233	cytoplasmic translational termination
SynPROS71_00748	COG0528	UMP kinase activity
SynPROS71_00751	COG2226	methyltransferase
SynPROS71_00753	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROS71_00754	COG0028	Belongs to the TPP enzyme family
SynPROS71_00758	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynPROS71_00759	COG1496	oxidoreductase activity
SynPROS71_00761	COG0539	negative regulation of cytoplasmic translation
SynPROS71_00764	COG3396	Phenylacetate-CoA oxygenase
SynPROS71_00765	COG5322	oxidoreductase activity
SynPROS71_00766	COG0825	malonyl-CoA metabolic process
SynPROS71_00768	COG0302	gtp cyclohydrolase
SynPROS71_00770	COG0135	phosphoribosylanthranilate isomerase activity
SynPROS71_00771	COG1994	Peptidase M50
SynPROS71_00771	COG0517	IMP dehydrogenase activity
SynPROS71_00772	COG0095	Lipoate-protein ligase
SynPROS71_00773	COG0730	response to heat
SynPROS71_00780	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynPROS71_00782	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynPROS71_00783	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynPROS71_00786	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynPROS71_00787	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynPROS71_00789	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynPROS71_00790	COG1850	ribulose-bisphosphate carboxylase activity
SynPROS71_00791	COG4451	ribulose bisphosphate carboxylase, small
SynPROS71_00796	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynPROS71_00797	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynPROS71_00798	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS71_00804	COG0251	oxidation-reduction process
SynPROS71_00805	COG3842	ATPase activity
SynPROS71_00806	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynPROS71_00807	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynPROS71_00808	COG1132	(ABC) transporter
SynPROS71_00810	COG0456	acetyltransferase
SynPROS71_00813	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynPROS71_00814	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynPROS71_00819	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynPROS71_00820	COG0811	peptide transport
SynPROS71_00826	COG1845	cytochrome c oxidase, subunit III
SynPROS71_00827	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynPROS71_00828	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynPROS71_00828	COG2010	Cytochrome c
SynPROS71_00833	COG0659	secondary active sulfate transmembrane transporter activity
SynPROS71_00834	COG0418	dihydroorotase activity
SynPROS71_00842	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynPROS71_00842	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynPROS71_00847	COG0159	tryptophan synthase activity
SynPROS71_00850	COG2010	Cytochrome c
SynPROS71_00856	COG3339	Conserved Protein
SynPROS71_00858	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROS71_00861	COG1376	ErfK ybiS ycfS ynhG family protein
SynPROS71_00862	COG0140	phosphoribosyl-ATP diphosphatase activity
SynPROS71_00862	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynPROS71_00864	COG0542	response to heat
SynPROS71_00868	COG3794	PFAM blue (type 1) copper domain protein
SynPROS71_00870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynPROS71_00871	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynPROS71_00879	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynPROS71_00880	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SynPROS71_00886	COG0339	signal peptide processing
SynPROS71_00887	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS71_00888	COG0083	homoserine kinase activity
SynPROS71_00889	COG0837	glucose binding
SynPROS71_00891	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynPROS71_00895	COG0180	Tryptophanyl-tRNA synthetase
SynPROS71_00900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynPROS71_00903	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SynPROS71_00908	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROS71_00909	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynPROS71_00916	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynPROS71_00918	COG2226	methyltransferase
SynPROS71_00924	COG3781	membrane
SynPROS71_00929	COG1064	alcohol dehydrogenase
SynPROS71_00937	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynPROS71_00971	COG0590	tRNA wobble adenosine to inosine editing
SynPROS71_00978	COG0484	heat shock protein binding
SynPROS71_00985	COG0405	Gamma-glutamyltransferase
SynPROS71_00989	COG3961	Belongs to the TPP enzyme family
SynPROS71_00991	COG1454	alcohol dehydrogenase
SynPROS71_00998	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SynPROS71_00999	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SynPROS71_01003	COG3895	Periplasmic Protein
SynPROS71_01009	COG0671	phosphoesterase, PA-phosphatase related
SynPROS71_01010	COG1487	ribonuclease activity
SynPROS71_01030	COG0189	ligase activity
SynPROS71_01030	COG4067	protein conserved in archaea
SynPROS71_01032	COG0346	lactoylglutathione lyase activity
SynPROS71_01033	COG1506	peptidase
SynPROS71_01033	COG0823	Involved in the tonB-independent uptake of proteins
SynPROS71_01046	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SynPROS71_01080	COG0717	Belongs to the dCTP deaminase family
SynPROS71_01081	COG0300	oxidoreductase activity
SynPROS71_01106	COG0651	ATP synthesis coupled electron transport
SynPROS71_01107	COG1006	Multisubunit Na H antiporter MnhC subunit
SynPROS71_01109	COG3527	Alpha-acetolactate decarboxylase
SynPROS71_01110	COG0028	Belongs to the TPP enzyme family
SynPROS71_01119	COG1121	(ABC) transporter
SynPROS71_01120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynPROS71_01124	COG2010	Cytochrome c
SynPROS71_01125	COG0701	Predicted permease
SynPROS71_01128	COG1121	(ABC) transporter
SynPROS71_01129	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynPROS71_01147	COG2124	cytochrome p450
SynPROS71_01170	COG2132	Multicopper oxidase
SynPROS71_01173	COG5002	protein histidine kinase activity
SynPROS71_01189	COG0681	Belongs to the peptidase S26 family
SynPROS71_01190	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynPROS71_01192	COG1376	ErfK ybiS ycfS ynhG family protein
SynPROS71_01193	COG0297	glycogen (starch) synthase activity
SynPROS71_01195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynPROS71_01197	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynPROS71_01199	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynPROS71_01200	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynPROS71_01201	COG2045	Belongs to the ComB family
SynPROS71_01204	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynPROS71_01205	COG0142	geranyltranstransferase activity
SynPROS71_01206	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynPROS71_01208	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynPROS71_01210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynPROS71_01211	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SynPROS71_01213	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynPROS71_01214	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROS71_01217	COG2146	nitrite reductase [NAD(P)H] activity
SynPROS71_01220	COG0189	ligase activity
SynPROS71_01225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynPROS71_01227	COG1132	(ABC) transporter
SynPROS71_01229	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynPROS71_01230	COG0505	Belongs to the CarA family
SynPROS71_01232	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynPROS71_01233	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynPROS71_01235	COG0154	amidase activity
SynPROS71_01236	COG0587	DNA-directed DNA polymerase activity
SynPROS71_01238	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynPROS71_01239	COG0632	four-way junction helicase activity
SynPROS71_01242	COG0358	DNA primase activity
SynPROS71_01244	COG0446	pyridine nucleotide-disulphide oxidoreductase
SynPROS71_01245	COG0798	PFAM Bile acid sodium symporter
SynPROS71_01251	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynPROS71_01255	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynPROS71_01256	COG2308	Evidence 4 Homologs of previously reported genes of
SynPROS71_01256	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynPROS71_01267	COG2197	response regulator
SynPROS71_01288	COG0861	Integral membrane protein TerC family
SynPROS71_01292	COG0513	Belongs to the DEAD box helicase family
SynPROS71_01293	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynPROS71_01295	COG0312	modulator of DNA gyrase
SynPROS71_01296	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynPROS71_01299	COG0163	prenyltransferase activity
SynPROS71_01300	COG0557	exoribonuclease II activity
SynPROS71_01302	COG2119	membrane
SynPROS71_01306	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynPROS71_01306	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynPROS71_01310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynPROS71_01311	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROS71_01312	COG1615	UPF0182 protein
SynPROS71_01313	COG0450	alkyl hydroperoxide reductase
SynPROS71_01316	COG0739	heme binding
SynPROS71_01317	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynPROS71_01324	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynPROS71_01327	COG0129	dihydroxy-acid dehydratase activity
SynPROS71_01329	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynPROS71_01332	COG2211	Major facilitator Superfamily
SynPROS71_01335	COG0300	oxidoreductase activity
SynPROS71_01337	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynPROS71_01338	COG0047	phosphoribosylformylglycinamidine synthase activity
SynPROS71_01339	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynPROS71_01341	COG0191	fructose-bisphosphate aldolase activity
SynPROS71_01342	COG0673	inositol 2-dehydrogenase activity
SynPROS71_01344	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynPROS71_01345	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynPROS71_01347	COG3954	Phosphoribulokinase
SynPROS71_01348	COG0473	3-isopropylmalate dehydrogenase activity
SynPROS71_01349	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynPROS71_01350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynPROS71_01353	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynPROS71_01356	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynPROS71_01357	COG2197	response regulator
SynPROS71_01359	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynPROS71_01365	COG1376	ErfK ybiS ycfS ynhG family protein
SynPROS71_01370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROS71_01372	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynPROS71_01375	COG3659	wide pore channel activity
SynPROS71_01376	COG1119	ATPase activity
SynPROS71_01378	COG0494	nUDIX hydrolase
SynPROS71_01386	COG1201	RNA secondary structure unwinding
SynPROS71_01390	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynPROS71_01392	COG1793	dna ligase
SynPROS71_01394	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SynPROS71_01394	COG1793	dna ligase
SynPROS71_01401	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynPROS71_01402	COG1175	transmembrane transport
SynPROS71_01403	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynPROS71_01407	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynPROS71_01412	COG0740	serine-type endopeptidase activity
SynPROS71_01414	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROS71_01415	COG0577	efflux transmembrane transporter activity
SynPROS71_01415	COG1136	(ABC) transporter
SynPROS71_01416	COG0469	pyruvate kinase activity
SynPROS71_01420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynPROS71_01421	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynPROS71_01426	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynPROS71_01427	COG0598	Magnesium transport protein CorA
SynPROS71_01429	COG3842	ATPase activity
SynPROS71_01432	COG1653	transport
SynPROS71_01433	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynPROS71_01434	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynPROS71_01435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynPROS71_01436	COG0326	Molecular chaperone. Has ATPase activity
SynPROS71_01438	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynPROS71_01439	COG0483	inositol monophosphate 1-phosphatase activity
SynPROS71_01440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynPROS71_01442	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynPROS71_01443	COG0581	inorganic phosphate transmembrane transporter activity
SynPROS71_01444	COG0573	inorganic phosphate transmembrane transporter activity
SynPROS71_01445	COG0443	Heat shock 70 kDa protein
SynPROS71_01446	COG0484	heat shock protein binding
SynPROS71_01448	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynPROS71_01449	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynPROS71_01450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynPROS71_01451	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynPROS71_01451	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynPROS71_01452	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynPROS71_01453	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynPROS71_01458	COG0166	Belongs to the GPI family
SynPROS71_01459	COG0495	leucyl-tRNA aminoacylation
SynPROS71_01461	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynPROS71_01462	COG1104	cysteine desulfurase activity
SynPROS71_01467	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynPROS71_01468	COG0322	excinuclease ABC activity
SynPROS71_01470	COG3046	protein related to deoxyribodipyrimidine photolyase
SynPROS71_01471	COG1981	membrane
SynPROS71_01475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynPROS71_01476	COG0646	methionine synthase
SynPROS71_01476	COG1410	methionine synthase
SynPROS71_01481	COG2385	sporulation resulting in formation of a cellular spore
SynPROS71_01483	COG1191	sigma factor activity
SynPROS71_01489	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynPROS71_01490	COG0072	phenylalanine-tRNA ligase activity
SynPROS71_01491	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynPROS71_01492	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynPROS71_01493	COG0557	exoribonuclease II activity
SynPROS71_01496	COG0363	glucosamine-6-phosphate deaminase activity
SynPROS71_01497	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynPROS71_01498	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROS71_01499	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynPROS71_01500	COG1494	fructose-1,6-bisphosphatase
SynPROS71_01501	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynPROS71_01504	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynPROS71_01511	COG3220	belongs to the UPF0276 family
SynPROS71_01516	COG1217	gtp-binding protein TYPA
SynPROS71_01517	COG0826	peptidase U32
SynPROS71_01519	COG0644	oxidoreductase
SynPROS71_01520	COG0751	glycine-tRNA ligase activity
SynPROS71_01521	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynPROS71_01522	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynPROS71_01523	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynPROS71_01525	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynPROS71_01526	COG0052	Belongs to the universal ribosomal protein uS2 family
SynPROS71_01528	COG1216	Glycosyl transferase, family 2
SynPROS71_01534	COG0612	Peptidase, M16
SynPROS71_01538	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynPROS71_01539	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SynPROS71_01542	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynPROS71_01545	COG0174	glutamine synthetase
SynPROS71_01548	COG2226	methyltransferase
SynPROS71_01554	COG0515	serine threonine protein kinase
SynPROS71_01555	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynPROS71_01557	COG0628	permease
SynPROS71_01558	COG0628	permease
SynPROS71_01560	COG0426	domain, Protein
SynPROS71_01560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynPROS71_01563	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynPROS71_01564	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynPROS71_01565	COG0022	dehydrogenase e1 component
SynPROS71_01565	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynPROS71_01567	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynPROS71_01568	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynPROS71_01575	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynPROS71_01578	COG0271	Belongs to the BolA IbaG family
SynPROS71_01579	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynPROS71_01581	COG0745	RESPONSE REGULATOR receiver
SynPROS71_01585	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynPROS71_01595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynPROS71_01597	COG0735	belongs to the Fur family
SynPROS71_01599	COG1799	cell septum assembly
SynPROS71_01606	COG0420	3'-5' exonuclease activity
SynPROS71_01610	COG0477	Major facilitator Superfamily
SynPROS71_01612	COG2873	o-acetylhomoserine
SynPROS71_01613	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynPROS71_01620	COG0765	amino acid transport
SynPROS71_01622	COG4597	amino acid ABC transporter
SynPROS71_01623	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynPROS71_01625	COG0659	secondary active sulfate transmembrane transporter activity
SynPROS71_01635	COG0799	negative regulation of ribosome biogenesis
SynPROS71_01637	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynPROS71_01639	COG1115	amino acid carrier protein
SynPROS71_01641	COG1132	(ABC) transporter
SynPROS71_01642	COG2501	S4 domain
SynPROS71_01643	COG0149	triose-phosphate isomerase activity
SynPROS71_01644	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynPROS71_01646	COG1429	ligase activity, forming nitrogen-metal bonds
SynPROS71_01647	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynPROS71_01649	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROS71_01652	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynPROS71_01671	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynPROS71_01672	COG0640	Transcriptional regulator
SynPROS71_01681	COG3639	organic phosphonate transmembrane transporter activity
SynPROS71_01682	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynPROS71_01682	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynPROS71_01683	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynPROS71_01684	COG0436	Aminotransferase
SynPROS71_01686	COG1573	uracil-dna glycosylase
SynPROS71_01687	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynPROS71_01688	COG0793	Belongs to the peptidase S41A family
SynPROS71_01692	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynPROS71_01697	COG1836	PFAM Integral membrane protein DUF92
SynPROS71_01702	COG1122	ATPase activity
SynPROS71_01703	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynPROS71_01707	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynPROS71_01708	COG4106	trans-aconitate 2-methyltransferase activity
SynPROS71_01709	COG0668	transmembrane transport
SynPROS71_01722	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynPROS71_01723	COG1074	ATP-dependent DNA helicase activity
SynPROS71_01724	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynPROS71_01726	COG0513	Belongs to the DEAD box helicase family
SynPROS71_01730	COG0724	RNA recognition motif
SynPROS71_01732	COG1132	(ABC) transporter
SynPROS71_01733	COG0475	glutathione-regulated potassium exporter activity
SynPROS71_01733	COG0589	response to stress
SynPROS71_01737	COG1404	Belongs to the peptidase S8 family
SynPROS71_01745	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynPROS71_01746	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynPROS71_01749	COG1054	Belongs to the UPF0176 family
SynPROS71_01750	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynPROS71_01751	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynPROS71_01752	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynPROS71_01753	COG0019	diaminopimelate decarboxylase activity
SynPROS71_01756	COG0542	response to heat
SynPROS71_01757	COG0371	Dehydrogenase
SynPROS71_01758	COG0596	Alpha beta hydrolase
SynPROS71_01758	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SynPROS71_01758	COG2226	methyltransferase
SynPROS71_01760	COG0575	Belongs to the CDS family
SynPROS71_01761	COG1982	Orn Lys Arg decarboxylase major
SynPROS71_01763	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynPROS71_01765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROS71_01766	COG0745	RESPONSE REGULATOR receiver
SynPROS71_01767	COG5002	protein histidine kinase activity
SynPROS71_01768	COG1187	pseudouridine synthase activity
SynPROS71_01770	COG1640	4-alpha-glucanotransferase
SynPROS71_01771	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
SynPROS71_01774	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynPROS71_01776	COG0308	aminopeptidase N
SynPROS71_01779	COG2205	protein histidine kinase activity
SynPROS71_01783	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SynPROS71_01785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynPROS71_01786	COG3429	Glucose-6-phosphate dehydrogenase subunit
SynPROS71_01786	COG3409	Peptidoglycan-binding domain 1 protein
SynPROS71_01787	COG1797	cobyrinic acid a,c-diamide synthase activity
SynPROS71_01788	COG1254	Belongs to the acylphosphatase family
SynPROS71_01789	COG0406	alpha-ribazole phosphatase activity
SynPROS71_01793	COG0142	geranyltranstransferase activity
SynPROS71_01794	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynPROS71_01795	COG1480	7TM receptor with intracellular HD hydrolase
SynPROS71_01796	COG0564	pseudouridine synthase activity
SynPROS71_01800	COG0011	TIGRFAM Protein of
SynPROS71_01804	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynPROS71_01809	COG0395	ABC-type sugar transport system, permease component
SynPROS71_01810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynPROS71_01811	COG1543	Belongs to the glycosyl hydrolase 57 family
SynPROS71_01812	COG0644	oxidoreductase
SynPROS71_01813	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynPROS71_01815	COG0516	GMP reductase activity
SynPROS71_01816	COG3118	belongs to the thioredoxin family
SynPROS71_01817	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynPROS71_01819	COG2010	Cytochrome c
SynPROS71_01823	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynPROS71_01824	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynPROS71_01825	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynPROS71_01828	COG2166	iron-sulfur cluster assembly
SynPROS71_01829	COG0460	homoserine dehydrogenase
SynPROS71_01832	COG0601	transmembrane transport
SynPROS71_01837	COG4095	Psort location CytoplasmicMembrane, score
SynPROS71_01839	COG0012	GTP binding
SynPROS71_01840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynPROS71_01841	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynPROS71_01841	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynPROS71_01842	COG0215	cysteine-tRNA ligase activity
SynPROS71_01845	COG0733	neurotransmitter:sodium symporter activity
SynPROS71_01846	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynPROS71_01859	COG0492	ferredoxin-NADP+ reductase activity
SynPROS71_01860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynPROS71_01862	COG1187	pseudouridine synthase activity
SynPROS71_01863	COG2226	methyltransferase
SynPROS71_01865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynPROS71_01869	COG0440	acetolactate synthase activity
SynPROS71_01870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynPROS71_01881	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SynPROS71_01889	COG0424	maF-like protein
SynPROS71_01891	COG1492	cobalamin metabolic process
SynPROS71_01896	COG0432	Pfam Uncharacterised protein family UPF0047
SynPROS71_01897	COG0477	Major facilitator Superfamily
SynPROS71_01908	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynPROS71_01912	COG0393	Putative heavy-metal-binding
SynPROS71_01915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynPROS71_01916	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROS71_01920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynPROS71_01920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynPROS71_01947	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynPROS71_01948	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynPROS71_01949	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynPROS71_01950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynPROS71_01952	COG0196	riboflavin kinase activity
SynPROS71_01954	COG0352	thiamine-phosphate diphosphorylase activity
SynPROS71_01959	COG1691	(AIR) carboxylase
SynPROS71_01961	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SynPROS71_01962	COG0336	Belongs to the RNA methyltransferase TrmD family
SynPROS71_01964	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynPROS71_01967	COG0670	Belongs to the BI1 family
SynPROS71_01968	COG1702	phosphate starvation-inducible protein PhoH
SynPROS71_01969	COG0228	four-way junction DNA binding
SynPROS71_01970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynPROS71_01973	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynPROS71_01974	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynPROS71_01975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROS71_01976	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynPROS71_01976	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynPROS71_01977	COG0482	sulfurtransferase activity
SynPROS71_01978	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynPROS71_01981	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SynPROS71_01982	COG0134	indole-3-glycerol-phosphate synthase activity
SynPROS71_01983	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynPROS71_01984	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynPROS71_01987	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynPROS71_01988	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynPROS71_01989	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynPROS71_01990	COG0285	dihydrofolate synthase activity
SynPROS71_01991	COG1357	PFAM Pentapeptide repeats (8 copies)
SynPROS71_01997	COG4948	Mandelate Racemase Muconate Lactonizing
SynPROS71_01998	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynPROS71_01999	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynPROS71_02002	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynPROS71_02003	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynPROS71_02004	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynPROS71_02005	COG4956	integral membrane protein (PIN domain superfamily)
SynPROS71_02006	COG0740	serine-type endopeptidase activity
SynPROS71_02007	COG0740	serine-type endopeptidase activity
SynPROS71_02008	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynPROS71_02009	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynPROS71_02018	COG2217	Heavy metal translocating P-type atpase
SynPROS71_02028	COG0752	glycyl-tRNA synthetase alpha subunit
SynPROS71_02030	COG2226	methyltransferase
SynPROS71_02032	COG0107	imidazoleglycerol-phosphate synthase activity
SynPROS71_02034	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynPROS71_02035	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynPROS71_02036	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynPROS71_02036	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynPROS71_02040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynPROS71_02041	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynPROS71_02044	COG5002	protein histidine kinase activity
SynPROS71_02045	COG2205	protein histidine kinase activity
SynPROS71_02050	COG0745	RESPONSE REGULATOR receiver
SynPROS71_02051	COG5002	protein histidine kinase activity
SynPROS71_02059	COG0481	GTPase activity
SynPROS71_02060	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynPROS71_02062	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynPROS71_02063	COG0523	cobalamin synthesis protein
SynPROS71_02065	COG1840	ABC-type Fe3 transport system, periplasmic component
SynPROS71_02069	COG2271	Major facilitator Superfamily
SynPROS71_02071	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynPROS71_02076	COG0277	FAD linked oxidase domain protein
SynPROS71_02077	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynPROS71_02079	COG1666	GTP binding
SynPROS71_02082	COG0330	HflC and HflK could
SynPROS71_02085	COG0857	belongs to the CobB CobQ family
SynPROS71_02087	COG3000	fatty acid hydroxylase
SynPROS71_02087	COG0300	oxidoreductase activity
SynPROS71_02088	COG0024	Methionine aminopeptidase
SynPROS71_02090	COG0335	large ribosomal subunit rRNA binding
SynPROS71_02094	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynPROS71_02095	COG3263	regulation of cellular component size
SynPROS71_02100	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROS71_02101	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynPROS71_02104	COG0194	GDP metabolic process
SynPROS71_02105	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynPROS71_02106	COG0805	protein transport
SynPROS71_02108	COG0723	plastoquinol--plastocyanin reductase activity
SynPROS71_02109	COG3258	Cytochrome c
SynPROS71_02110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynPROS71_02111	COG2875	Belongs to the precorrin methyltransferase family
SynPROS71_02114	COG0248	Ppx GppA phosphatase
SynPROS71_02115	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynPROS71_02116	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynPROS71_02117	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynPROS71_02119	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynPROS71_02120	COG1028	Short-chain dehydrogenase reductase Sdr
SynPROS71_02122	COG0459	protein refolding
SynPROS71_02124	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynPROS71_02128	COG0109	protoheme IX farnesyltransferase activity
SynPROS71_02129	COG1612	heme a metabolic process
SynPROS71_02132	COG1845	cytochrome c oxidase, subunit III
SynPROS71_02139	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynPROS71_02142	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynPROS71_02143	COG1007	ATP synthesis coupled electron transport
SynPROS71_02144	COG0577	efflux transmembrane transporter activity
SynPROS71_02144	COG1136	(ABC) transporter
SynPROS71_02145	COG0745	RESPONSE REGULATOR receiver
SynPROS71_02146	COG0739	heme binding
SynPROS71_02147	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynPROS71_02147	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynPROS71_02148	COG0436	Aminotransferase
SynPROS71_02149	COG3118	belongs to the thioredoxin family
SynPROS71_02150	COG1842	Phage shock protein A
SynPROS71_02153	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynPROS71_02154	COG0438	transferase activity, transferring glycosyl groups
SynPROS71_02155	COG0697	spore germination
SynPROS71_02156	COG0616	signal peptide processing
SynPROS71_02159	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynPROS71_02160	COG0594	ribonuclease P activity
SynPROS71_02162	COG0706	membrane insertase activity
SynPROS71_02164	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROS71_02166	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynPROS71_02167	COG0750	zinc metalloprotease
SynPROS71_02168	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynPROS71_02169	COG1185	polyribonucleotide nucleotidyltransferase activity
SynPROS71_02171	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynPROS71_02203	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynPROS71_02204	COG0776	regulation of translation
SynPROS71_02208	COG2211	Major facilitator Superfamily
SynPROS71_02209	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynPROS71_02212	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynPROS71_02219	COG0284	orotidine-5'-phosphate decarboxylase activity
SynPROS71_02223	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynPROS71_02228	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynPROS71_02231	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynPROS71_02233	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynPROS71_02234	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynPROS71_02235	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynPROS71_02237	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynPROS71_02239	COG0151	Belongs to the GarS family
SynPROS71_02240	COG5002	protein histidine kinase activity
SynPROS71_02241	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynPROS71_02242	COG4251	negative regulation of phosphorylation
SynPROS71_02244	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynPROS71_02245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynPROS71_02248	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynPROS71_02249	COG0217	transcriptional regulatory protein
SynPROS71_02251	COG0363	glucosamine-6-phosphate deaminase activity
SynPROS71_02252	COG2247	cell wall binding repeat
SynPROS71_02252	COG2385	sporulation resulting in formation of a cellular spore
SynPROS71_02253	COG1234	tRNA 3'-trailer cleavage
SynPROS71_02254	COG2010	Cytochrome c
SynPROS71_02257	COG2264	protein methyltransferase activity
SynPROS71_02258	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynPROS71_02262	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynPROS71_02270	COG0443	Heat shock 70 kDa protein
SynPROS71_02273	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynPROS71_02274	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynPROS71_02276	COG1970	mechanosensitive ion channel activity
SynPROS71_02277	COG0459	protein refolding
SynPROS71_02278	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynPROS71_02280	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynPROS71_02281	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynPROS71_02284	COG0387	Pfam Sodium calcium exchanger
SynPROS71_02285	COG0006	proline dipeptidase activity
SynPROS71_02286	COG1253	flavin adenine dinucleotide binding
SynPROS71_02288	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynPROS71_02289	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynPROS71_02289	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynPROS71_02293	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynPROS71_02295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynPROS71_02298	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynPROS71_02299	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynPROS71_02300	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynPROS71_02301	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynPROS71_02302	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynPROS71_02303	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynPROS71_02304	COG0356	it plays a direct role in the translocation of protons across the membrane
SynPROS71_02306	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynPROS71_02307	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROS71_02312	COG0772	Belongs to the SEDS family
SynPROS71_02314	COG1333	cytochrome c biogenesis protein
SynPROS71_02315	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynPROS71_02319	COG0347	Belongs to the P(II) protein family
SynPROS71_02320	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SynPROS71_02322	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynPROS71_02323	COG0114	fumarate hydratase activity
SynPROS71_02324	COG4581	dead DEAH box helicase
SynPROS71_02325	COG0385	Bile acid
SynPROS71_02326	COG0156	8-amino-7-oxononanoate synthase activity
SynPROS71_02329	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynPROS71_02329	COG4106	trans-aconitate 2-methyltransferase activity
SynPROS71_02332	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynPROS71_02335	COG0357	Ribosomal RNA small subunit methyltransferase G
SynPROS71_02342	COG2223	nitrite transmembrane transporter activity
SynPROS71_02343	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynPROS71_02344	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROS71_02345	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynPROS71_02347	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynPROS71_02348	COG0085	RNA polymerase activity
SynPROS71_02350	COG0084	hydrolase, TatD family'
SynPROS71_02351	COG0268	Binds directly to 16S ribosomal RNA
SynPROS71_02352	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynPROS71_02353	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynPROS71_02354	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynPROS71_02357	COG2197	response regulator
SynPROS71_02363	COG0641	radical SAM
SynPROS71_02365	COG0779	Required for maturation of 30S ribosomal subunits
SynPROS71_02366	COG0195	Participates in both transcription termination and antitermination
SynPROS71_02368	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynPROS71_02376	COG2988	succinylglutamate desuccinylase activity
SynPROS71_02379	COG0488	(ABC) transporter
SynPROS71_02383	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynPROS71_02384	COG3842	ATPase activity
SynPROS71_02385	COG1193	negative regulation of DNA recombination
SynPROS71_02388	COG0113	porphobilinogen synthase activity
SynPROS71_02389	COG0484	heat shock protein binding
SynPROS71_02391	COG0659	secondary active sulfate transmembrane transporter activity
SynPROS71_02393	COG0431	NADPH-dependent FMN reductase
SynPROS71_02397	COG0300	oxidoreductase activity
SynPROS71_02406	COG0116	Belongs to the methyltransferase superfamily
SynPROS71_02410	COG1196	nuclear chromosome segregation
SynPROS71_02413	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynPROS71_02417	COG0439	Biotin carboxylase
SynPROS71_02421	COG0515	serine threonine protein kinase
SynPROS71_02425	COG4178	(ABC) transporter
SynPROS71_02426	COG0537	adenosine 5'-monophosphoramidase activity
SynPROS71_02427	COG0606	chelatase, subunit chli
SynPROS71_02429	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynPROS71_02432	COG0242	peptide deformylase activity
SynPROS71_02435	COG0235	Class ii aldolase
SynPROS71_02436	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynPROS71_02439	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynPROS71_02440	COG0719	Fe-S assembly protein
SynPROS71_02441	COG0396	ATPase activity
SynPROS71_02442	COG0719	Fe-S assembly protein
SynPROS71_02443	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynPROS71_02444	COG1830	Aldolase
SynPROS71_02448	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROS71_02452	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SynPROS71_02457	COG0033	Phosphoglucomutase
SynPROS71_02461	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SynPROS71_02465	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynPROS71_02466	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynPROS71_02467	COG0175	sulfate reduction
SynPROS71_02468	COG1252	NADH dehydrogenase
SynPROS71_02469	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynPROS71_02470	COG0471	metal ion transport
SynPROS71_02470	COG3273	potassium ion transport
SynPROS71_02471	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynPROS71_02472	COG0569	domain protein
SynPROS71_02473	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynPROS71_02479	COG0488	(ABC) transporter
SynPROS71_02481	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynPROS71_02484	COG1643	Atp-dependent helicase
SynPROS71_02485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROS71_02487	COG1570	exodeoxyribonuclease VII activity
SynPROS71_02488	COG1722	exodeoxyribonuclease VII activity
SynPROS71_02497	COG0483	inositol monophosphate 1-phosphatase activity
SynPROS71_02500	COG1968	undecaprenyl-diphosphatase activity
SynPROS71_02502	COG1555	photosystem II stabilization
SynPROS71_02503	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynPROS71_02505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynPROS71_02508	COG1032	radical SAM domain protein
SynPROS71_02514	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynPROS71_02519	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynPROS71_02521	COG0457	Tetratricopeptide repeat
SynPROS71_02521	COG0463	Glycosyl transferase, family 2
SynPROS71_02522	COG1587	Uroporphyrinogen-III synthase
SynPROS71_02525	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynPROS71_02526	COG0316	Belongs to the HesB IscA family
SynPROS71_02529	COG1090	epimerase
SynPROS71_02533	COG0484	heat shock protein binding
SynPROS71_02534	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynPROS71_02535	COG3659	wide pore channel activity
SynPROS71_02536	COG3659	wide pore channel activity
SynPROS71_02543	COG1122	ATPase activity
SynPROS71_02546	COG0745	RESPONSE REGULATOR receiver
SynPROS71_02548	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynPROS71_02549	COG2217	Heavy metal translocating P-type atpase
SynPROS71_02550	COG3063	Type IV pilus biogenesis stability protein PilW
SynPROS71_02551	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynPROS71_02553	COG0416	fatty acid biosynthetic process
SynPROS71_02554	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynPROS71_02555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynPROS71_02558	COG1214	PFAM Peptidase M22, glycoprotease
SynPROS71_02560	COG0617	tRNA 3'-terminal CCA addition
SynPROS71_02574	COG1562	ergosterol biosynthetic process
SynPROS71_02575	COG0745	RESPONSE REGULATOR receiver
SynPROS71_02578	COG0493	'glutamate synthase
SynPROS71_02578	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynPROS71_02581	COG0583	DNA-binding transcription factor activity
SynPROS71_02583	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynPROS71_02584	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS71_02586	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynPROS71_02588	COG2197	response regulator
SynPROS71_02591	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynPROS71_02592	COG0713	ATP synthesis coupled electron transport
SynPROS71_02593	COG0839	Belongs to the complex I subunit 6 family
SynPROS71_02594	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS71_02595	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynPROS71_02596	COG0372	Belongs to the citrate synthase family
SynPROS71_02600	COG1420	regulation of RNA biosynthetic process
SynPROS71_02601	COG0133	tryptophan synthase activity
SynPROS71_02603	COG0023	Translation Initiation Factor
SynPROS71_02604	COG0529	Catalyzes the synthesis of activated sulfate
SynPROS71_02605	COG0628	permease
SynPROS71_02606	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynPROS71_02608	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynPROS71_02610	COG0564	pseudouridine synthase activity
SynPROS71_02611	COG0745	RESPONSE REGULATOR receiver
SynPROS71_02616	COG0275	rRNA processing
SynPROS71_02617	COG0649	NAD binding
SynPROS71_02618	COG0824	Thioesterase
SynPROS71_02621	COG1575	Belongs to the MenA family. Type 1 subfamily
SynPROS71_02624	COG0189	ligase activity
SynPROS71_02625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynPROS71_02628	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynPROS71_02630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynPROS71_02631	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynPROS71_02632	COG0512	Glutamine amidotransferase of anthranilate synthase
SynPROS71_02634	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynPROS71_02638	COG0252	asparaginase activity
SynPROS71_02640	COG0018	arginyl-trna synthetase
SynPROS71_02641	COG0157	Belongs to the NadC ModD family
SynPROS71_02643	COG0242	peptide deformylase activity
SynPROS71_02644	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynPROS71_02647	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynPROS71_02648	COG4172	Belongs to the ABC transporter superfamily
SynPROS71_02649	COG2909	trisaccharide binding
SynPROS71_02652	COG0564	pseudouridine synthase activity
SynPROS71_02653	COG2814	Major facilitator Superfamily
SynPROS71_02658	COG2124	cytochrome p450
SynPROS71_02660	COG0589	response to stress
SynPROS71_02661	COG0126	phosphoglycerate kinase activity
SynPROS71_02662	COG2084	Dehydrogenase
SynPROS71_02664	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynPROS71_02665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynPROS71_02670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynPROS71_02672	COG1459	type II secretion system
SynPROS71_02677	COG0714	Associated with various cellular activities
SynPROS71_02681	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SynPROS71_02681	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SynPROS71_02684	COG1450	Type ii and iii secretion system protein
SynPROS71_02688	COG0167	dihydroorotate dehydrogenase activity
SynPROS71_02689	COG0328	RNA-DNA hybrid ribonuclease activity
SynPROS71_02691	COG0222	ribosome binding
SynPROS71_02692	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynPROS71_02693	COG0081	regulation of translation
SynPROS71_02694	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynPROS71_02695	COG0250	Participates in transcription elongation, termination and antitermination
SynPROS71_02696	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynPROS71_02697	COG0542	response to heat
SynPROS71_02699	COG0148	phosphopyruvate hydratase activity
SynPROS71_02700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynPROS71_02716	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynPROS71_02717	COG0237	dephospho-CoA kinase activity
SynPROS71_02722	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynPROS71_02723	COG2022	thiamine diphosphate biosynthetic process
SynPROS71_02723	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynPROS71_02725	COG0105	UTP biosynthetic process
SynPROS71_02727	COG1166	arginine decarboxylase activity
SynPROS71_02728	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROS71_02741	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SynPROS71_02753	COG0668	transmembrane transport
SynPROS71_02756	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynPROS71_02758	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynPROS71_02763	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynPROS71_02763	COG0426	domain, Protein
SynPROS71_02764	COG0426	domain, Protein
SynPROS71_02764	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynPROS71_02767	COG1733	regulation of RNA biosynthetic process
SynPROS71_02770	COG1741	Belongs to the pirin family
SynPROS71_02777	COG0509	glycine decarboxylation via glycine cleavage system
SynPROS71_02778	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynPROS71_02782	COG0359	binds to the 23S rRNA
SynPROS71_02783	COG0305	Participates in initiation and elongation during chromosome replication
SynPROS71_02783	COG1372	Participates in initiation and elongation during chromosome replication
SynPROS71_02783	COG0305	Participates in initiation and elongation during chromosome replication
SynPROS71_02783	COG1372	Participates in initiation and elongation during chromosome replication
SynPROS71_02784	COG0445	tRNA wobble uridine modification
SynPROS71_02793	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynPROS71_02796	COG0398	Pfam SNARE associated Golgi protein
SynPROS71_02802	COG0668	transmembrane transport
SynPROS71_02806	COG0745	RESPONSE REGULATOR receiver
SynPROS71_02807	COG0525	valine-tRNA ligase activity
SynPROS71_02809	COG3264	Mechanosensitive ion channel
SynPROS71_02809	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SynPROS71_02817	COG3956	TIGRFAM MazG family protein
SynPROS71_02818	COG2272	Belongs to the type-B carboxylesterase lipase family
SynPROS71_02820	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynPROS71_02823	COG0010	Belongs to the arginase family
SynPROS71_02826	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynPROS71_02827	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynPROS71_02828	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROS71_02829	COG0783	Belongs to the Dps family
SynPROS71_02830	COG0504	CTP synthase activity
SynPROS71_02831	COG0602	queuosine metabolic process
SynPROS71_02832	COG4942	peptidase
SynPROS71_02833	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SynPROS71_02836	COG4574	serine-type endopeptidase inhibitor activity
SynPROS71_02838	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynPROS71_02839	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynPROS71_02841	COG0531	amino acid
SynPROS71_02844	COG0366	Alpha amylase catalytic
SynPROS71_02845	COG0463	Glycosyl transferase, family 2
SynPROS71_02852	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynPROS71_02853	COG0830	nickel cation binding
SynPROS71_02854	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynPROS71_02855	COG0829	nickel cation binding
SynPROS71_02856	COG0831	urea catabolic process
SynPROS71_02857	COG0832	Belongs to the urease beta subunit family
SynPROS71_02858	COG0804	urea catabolic process
SynPROS71_02863	COG0367	asparagine synthase
SynPROS71_02864	COG0540	Belongs to the ATCase OTCase family
SynPROS71_02868	COG2308	Evidence 4 Homologs of previously reported genes of
SynPROS71_02872	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynPROS71_02874	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynPROS71_02876	COG2116	formate transmembrane transporter activity
SynPROS71_02878	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynPROS71_02880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynPROS71_02883	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynPROS71_02884	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROS71_02885	COG0170	dolichyl monophosphate biosynthetic process
SynPROS71_02887	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynPROS71_02888	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynPROS71_02892	COG0788	formyltetrahydrofolate deformylase activity
SynPROS71_02897	COG0443	Heat shock 70 kDa protein
SynPROS71_02898	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynPROS71_02900	COG0360	Binds together with S18 to 16S ribosomal RNA
SynPROS71_02902	COG0137	argininosuccinate synthase activity
SynPROS71_02905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynPROS71_02910	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynPROS71_02911	COG0438	transferase activity, transferring glycosyl groups
SynPROS71_02914	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynPROS71_02916	COG0497	DNA recombination
SynPROS71_02917	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynPROS71_02919	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SynPROS71_50012	COG2094	Belongs to the DNA glycosylase MPG family