locus-tag	class	description
SynPROS91_00001	COG0592	DNA-directed DNA polymerase activity
SynPROS91_00003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynPROS91_00004	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynPROS91_00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynPROS91_00007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynPROS91_00010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynPROS91_00011	COG0552	protein localization to endoplasmic reticulum
SynPROS91_00012	COG2208	phosphoserine phosphatase activity
SynPROS91_00013	COG0165	Argininosuccinate lyase
SynPROS91_00014	COG0724	RNA recognition motif
SynPROS91_00015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynPROS91_00016	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynPROS91_00017	COG2081	HI0933 family
SynPROS91_00018	COG1459	type II secretion system
SynPROS91_00020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynPROS91_00021	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynPROS91_00022	COG0484	heat shock protein binding
SynPROS91_00024	COG1162	GTPase activity
SynPROS91_00025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynPROS91_00026	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynPROS91_00027	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynPROS91_00028	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynPROS91_00029	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynPROS91_00030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynPROS91_00031	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynPROS91_00032	COG0511	ligase activity, forming carbon-carbon bonds
SynPROS91_00033	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynPROS91_00049	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynPROS91_00050	COG0519	Catalyzes the synthesis of GMP from XMP
SynPROS91_00050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynPROS91_00054	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynPROS91_00054	COG0438	transferase activity, transferring glycosyl groups
SynPROS91_00055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynPROS91_00057	COG2022	thiamine diphosphate biosynthetic process
SynPROS91_00060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynPROS91_00061	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynPROS91_00062	COG2385	sporulation resulting in formation of a cellular spore
SynPROS91_00063	COG1215	transferase activity, transferring glycosyl groups
SynPROS91_00064	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynPROS91_00066	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynPROS91_00067	COG0740	serine-type endopeptidase activity
SynPROS91_00068	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynPROS91_00070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynPROS91_00071	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynPROS91_00072	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynPROS91_00074	COG0037	tRNA processing
SynPROS91_00077	COG0556	nucleotide-excision repair
SynPROS91_00080	COG2082	Precorrin-8x methylmutase
SynPROS91_00081	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynPROS91_00083	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynPROS91_00086	COG0438	transferase activity, transferring glycosyl groups
SynPROS91_00087	COG0653	protein targeting
SynPROS91_00088	COG1045	serine acetyltransferase
SynPROS91_00089	COG1725	Transcriptional regulator
SynPROS91_00092	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynPROS91_00093	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynPROS91_00094	COG1372	Participates in initiation and elongation during chromosome replication
SynPROS91_00094	COG0187	DNA topoisomerase II activity
SynPROS91_00096	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynPROS91_00097	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynPROS91_00098	COG0386	Belongs to the glutathione peroxidase family
SynPROS91_00099	COG2239	Acts as a magnesium transporter
SynPROS91_00100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROS91_00101	COG0596	Alpha beta hydrolase
SynPROS91_00103	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynPROS91_00108	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SynPROS91_00110	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynPROS91_00113	COG0586	Pfam SNARE associated Golgi protein
SynPROS91_00114	COG0629	single-stranded DNA binding
SynPROS91_00116	COG1792	Involved in formation and maintenance of cell shape
SynPROS91_00120	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynPROS91_00124	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynPROS91_00125	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynPROS91_00126	COG0515	serine threonine protein kinase
SynPROS91_00126	COG1357	PFAM Pentapeptide repeats (8 copies)
SynPROS91_00127	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynPROS91_00129	COG2255	four-way junction helicase activity
SynPROS91_00131	COG1473	amidohydrolase
SynPROS91_00134	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynPROS91_00136	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynPROS91_00137	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynPROS91_00138	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynPROS91_00139	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS91_00140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynPROS91_00142	COG0662	Cupin 2, conserved barrel domain protein
SynPROS91_00142	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynPROS91_00145	COG1028	Short-chain dehydrogenase reductase Sdr
SynPROS91_00145	COG3321	synthase
SynPROS91_00145	COG0604	alcohol dehydrogenase
SynPROS91_00149	COG2124	cytochrome p450
SynPROS91_00160	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynPROS91_00161	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynPROS91_00164	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynPROS91_00165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynPROS91_00167	COG1132	(ABC) transporter
SynPROS91_00168	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SynPROS91_00169	COG0579	oxidoreductase
SynPROS91_00170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynPROS91_00171	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SynPROS91_00172	COG4106	trans-aconitate 2-methyltransferase activity
SynPROS91_00173	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SynPROS91_00177	COG0022	dehydrogenase e1 component
SynPROS91_00180	COG0028	Belongs to the TPP enzyme family
SynPROS91_00187	COG0367	asparagine synthase
SynPROS91_00192	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynPROS91_00200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynPROS91_00201	COG0471	metal ion transport
SynPROS91_00201	COG3273	potassium ion transport
SynPROS91_00204	COG2089	acid synthase
SynPROS91_00206	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynPROS91_00213	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynPROS91_00215	COG3273	potassium ion transport
SynPROS91_00215	COG0471	metal ion transport
SynPROS91_00216	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynPROS91_00219	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROS91_00221	COG0571	ribonuclease III activity
SynPROS91_00226	COG1970	mechanosensitive ion channel activity
SynPROS91_00229	COG0058	SHG alpha-glucan phosphorylase activity
SynPROS91_00230	COG0475	glutathione-regulated potassium exporter activity
SynPROS91_00234	COG0277	FAD linked oxidase domain protein
SynPROS91_00236	COG0247	lactate metabolic process
SynPROS91_00237	COG0538	isocitrate dehydrogenase activity
SynPROS91_00240	COG5398	heme oxygenase
SynPROS91_00242	COG1132	(ABC) transporter
SynPROS91_00243	COG0438	transferase activity, transferring glycosyl groups
SynPROS91_00244	COG1215	transferase activity, transferring glycosyl groups
SynPROS91_00249	COG0617	tRNA 3'-terminal CCA addition
SynPROS91_00251	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynPROS91_00252	COG0124	histidyl-tRNA synthetase
SynPROS91_00253	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynPROS91_00260	COG4447	cellulose binding
SynPROS91_00261	COG1773	rubredoxin
SynPROS91_00262	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS91_00263	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS91_00264	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS91_00265	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynPROS91_00267	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SynPROS91_00268	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SynPROS91_00269	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynPROS91_00269	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynPROS91_00270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SynPROS91_00271	COG0494	nUDIX hydrolase
SynPROS91_00272	COG0415	Belongs to the DNA photolyase family
SynPROS91_00278	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynPROS91_00279	COG3781	membrane
SynPROS91_00280	COG0131	Imidazoleglycerol-phosphate dehydratase
SynPROS91_00281	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynPROS91_00283	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynPROS91_00287	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynPROS91_00288	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynPROS91_00290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynPROS91_00291	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynPROS91_00294	COG1253	flavin adenine dinucleotide binding
SynPROS91_00295	COG0673	inositol 2-dehydrogenase activity
SynPROS91_00299	COG0343	queuine tRNA-ribosyltransferase activity
SynPROS91_00306	COG0138	bifunctional purine biosynthesis protein purh
SynPROS91_00309	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynPROS91_00310	COG0004	ammonium transporteR
SynPROS91_00311	COG1489	DNA binding
SynPROS91_00313	COG0728	peptidoglycan biosynthetic process
SynPROS91_00318	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynPROS91_00319	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynPROS91_00320	COG1546	Belongs to the CinA family
SynPROS91_00320	COG1058	Belongs to the CinA family
SynPROS91_00321	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynPROS91_00322	COG0066	3-isopropylmalate dehydratase activity
SynPROS91_00329	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynPROS91_00330	COG0193	aminoacyl-tRNA hydrolase activity
SynPROS91_00333	COG4372	Transposase
SynPROS91_00334	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROS91_00335	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynPROS91_00337	COG0717	Belongs to the dCTP deaminase family
SynPROS91_00339	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynPROS91_00344	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynPROS91_00347	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynPROS91_00351	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynPROS91_00356	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynPROS91_00359	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynPROS91_00360	COG2094	Belongs to the DNA glycosylase MPG family
SynPROS91_00361	COG0540	Belongs to the ATCase OTCase family
SynPROS91_00370	COG3536	Protein conserved in bacteria
SynPROS91_00371	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynPROS91_00373	COG2046	Belongs to the sulfate adenylyltransferase family
SynPROS91_00373	COG0529	Catalyzes the synthesis of activated sulfate
SynPROS91_00374	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROS91_00375	COG0800	Aldolase
SynPROS91_00377	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynPROS91_00379	COG0463	Glycosyl transferase, family 2
SynPROS91_00381	COG0366	Alpha amylase catalytic
SynPROS91_00390	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynPROS91_00391	COG0436	Aminotransferase
SynPROS91_00393	COG1530	ribonuclease E activity
SynPROS91_00394	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynPROS91_00396	COG1605	Chorismate mutase
SynPROS91_00396	COG0077	Prephenate dehydratase
SynPROS91_00397	COG2226	methyltransferase
SynPROS91_00398	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynPROS91_00399	COG0051	transcription antitermination factor activity, RNA binding
SynPROS91_00400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynPROS91_00401	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynPROS91_00402	COG0049	tRNA binding
SynPROS91_00403	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynPROS91_00406	COG0069	glutamate synthase activity
SynPROS91_00406	COG0067	glutamate synthase
SynPROS91_00406	COG0070	glutamate synthase
SynPROS91_00408	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynPROS91_00414	COG2885	chlorophyll binding
SynPROS91_00415	COG2885	chlorophyll binding
SynPROS91_00417	COG3239	Fatty acid desaturase
SynPROS91_00423	COG0463	Glycosyl transferase, family 2
SynPROS91_00427	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynPROS91_00429	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynPROS91_00430	COG0254	rRNA binding
SynPROS91_00431	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynPROS91_00432	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynPROS91_00433	COG0101	tRNA pseudouridine synthase activity
SynPROS91_00434	COG0203	ribosomal protein L17
SynPROS91_00435	COG0202	RNA polymerase activity
SynPROS91_00436	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynPROS91_00437	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynPROS91_00438	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynPROS91_00439	COG0563	adenylate kinase activity
SynPROS91_00440	COG0201	protein transport
SynPROS91_00441	COG0200	Binds to the 23S rRNA
SynPROS91_00442	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynPROS91_00443	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynPROS91_00444	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynPROS91_00445	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynPROS91_00446	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynPROS91_00447	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynPROS91_00448	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynPROS91_00449	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynPROS91_00450	COG0255	Belongs to the universal ribosomal protein uL29 family
SynPROS91_00451	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynPROS91_00452	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynPROS91_00453	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynPROS91_00454	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynPROS91_00455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynPROS91_00456	COG0089	rRNA binding
SynPROS91_00457	COG0088	Forms part of the polypeptide exit tunnel
SynPROS91_00458	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynPROS91_00461	COG3854	ATPases associated with a variety of cellular activities
SynPROS91_00464	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynPROS91_00468	COG0287	Prephenate dehydrogenase
SynPROS91_00470	COG3001	Fructosamine kinase
SynPROS91_00474	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynPROS91_00475	COG1606	tRNA processing
SynPROS91_00477	COG0076	glutamate decarboxylase activity
SynPROS91_00478	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynPROS91_00480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynPROS91_00483	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynPROS91_00485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynPROS91_00487	COG5002	protein histidine kinase activity
SynPROS91_00488	COG0772	Belongs to the SEDS family
SynPROS91_00489	COG0489	protein tyrosine kinase activity
SynPROS91_00490	COG0408	coproporphyrinogen oxidase activity
SynPROS91_00499	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROS91_00502	COG0656	L-ascorbic acid biosynthetic process
SynPROS91_00504	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynPROS91_00505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynPROS91_00506	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynPROS91_00506	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynPROS91_00507	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynPROS91_00535	COG0237	dephospho-CoA kinase activity
SynPROS91_00539	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROS91_00560	COG1070	Carbohydrate kinase
SynPROS91_00561	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynPROS91_00562	COG0546	phosphoglycolate phosphatase activity
SynPROS91_00563	COG0539	negative regulation of cytoplasmic translation
SynPROS91_00564	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynPROS91_00568	COG0589	response to stress
SynPROS91_00572	COG2890	protein-(glutamine-N5) methyltransferase activity
SynPROS91_00577	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynPROS91_00578	COG2894	cell division
SynPROS91_00579	COG0850	regulation of cytokinetic process
SynPROS91_00580	COG1078	dGTPase activity
SynPROS91_00581	COG0793	Belongs to the peptidase S41A family
SynPROS91_00582	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynPROS91_00583	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynPROS91_00591	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynPROS91_00596	COG1012	belongs to the aldehyde dehydrogenase family
SynPROS91_00598	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynPROS91_00605	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynPROS91_00608	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynPROS91_00611	COG1215	transferase activity, transferring glycosyl groups
SynPROS91_00612	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynPROS91_00615	COG1160	GTP binding
SynPROS91_00616	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynPROS91_00618	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynPROS91_00619	COG1799	cell septum assembly
SynPROS91_00620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynPROS91_00621	COG0438	transferase activity, transferring glycosyl groups
SynPROS91_00623	COG1381	Involved in DNA repair and RecF pathway recombination
SynPROS91_00624	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynPROS91_00625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynPROS91_00626	COG0321	lipoyl(octanoyl) transferase activity
SynPROS91_00627	COG1022	Amp-dependent synthetase and ligase
SynPROS91_00629	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynPROS91_00631	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynPROS91_00632	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynPROS91_00650	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynPROS91_00651	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynPROS91_00653	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynPROS91_00655	COG1104	cysteine desulfurase activity
SynPROS91_00663	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynPROS91_00664	COG0579	oxidoreductase
SynPROS91_00666	COG0481	GTPase activity
SynPROS91_00675	COG5002	protein histidine kinase activity
SynPROS91_00676	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SynPROS91_00678	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynPROS91_00681	COG3695	enzyme binding
SynPROS91_00682	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynPROS91_00682	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynPROS91_00683	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynPROS91_00684	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynPROS91_00686	COG0107	imidazoleglycerol-phosphate synthase activity
SynPROS91_00688	COG2226	methyltransferase
SynPROS91_00691	COG0752	glycyl-tRNA synthetase alpha subunit
SynPROS91_00702	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynPROS91_00703	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynPROS91_00704	COG0740	serine-type endopeptidase activity
SynPROS91_00705	COG0740	serine-type endopeptidase activity
SynPROS91_00706	COG4956	integral membrane protein (PIN domain superfamily)
SynPROS91_00707	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynPROS91_00708	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynPROS91_00709	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynPROS91_00712	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynPROS91_00713	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynPROS91_00719	COG0285	dihydrofolate synthase activity
SynPROS91_00720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynPROS91_00722	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynPROS91_00725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynPROS91_00726	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynPROS91_00727	COG0134	indole-3-glycerol-phosphate synthase activity
SynPROS91_00739	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynPROS91_00740	COG0482	sulfurtransferase activity
SynPROS91_00741	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynPROS91_00741	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynPROS91_00743	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROS91_00751	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynPROS91_00752	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynPROS91_00754	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynPROS91_00755	COG0228	four-way junction DNA binding
SynPROS91_00756	COG1702	phosphate starvation-inducible protein PhoH
SynPROS91_00761	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynPROS91_00763	COG0336	Belongs to the RNA methyltransferase TrmD family
SynPROS91_00770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SynPROS91_00772	COG1691	(AIR) carboxylase
SynPROS91_00776	COG0352	thiamine-phosphate diphosphorylase activity
SynPROS91_00778	COG0196	riboflavin kinase activity
SynPROS91_00780	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynPROS91_00781	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynPROS91_00787	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynPROS91_00795	COG0477	Major facilitator Superfamily
SynPROS91_00798	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynPROS91_00798	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynPROS91_00800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROS91_00803	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynPROS91_00808	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynPROS91_00813	COG4638	Rieske (2fe-2S)
SynPROS91_00814	COG1116	anion transmembrane transporter activity
SynPROS91_00815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynPROS91_00818	COG0375	protein maturation
SynPROS91_00819	COG0010	Belongs to the arginase family
SynPROS91_00832	COG0668	transmembrane transport
SynPROS91_00846	COG1942	4-Oxalocrotonate Tautomerase
SynPROS91_00859	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynPROS91_00860	COG1376	ErfK ybiS ycfS ynhG family protein
SynPROS91_00872	COG0432	Pfam Uncharacterised protein family UPF0047
SynPROS91_00877	COG1492	cobalamin metabolic process
SynPROS91_00879	COG0424	maF-like protein
SynPROS91_00884	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynPROS91_00885	COG0440	acetolactate synthase activity
SynPROS91_00886	COG2267	carboxylic ester hydrolase activity
SynPROS91_00891	COG2226	methyltransferase
SynPROS91_00892	COG1187	pseudouridine synthase activity
SynPROS91_00894	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynPROS91_00895	COG0492	ferredoxin-NADP+ reductase activity
SynPROS91_00906	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynPROS91_00907	COG0733	neurotransmitter:sodium symporter activity
SynPROS91_00910	COG0215	cysteine-tRNA ligase activity
SynPROS91_00913	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynPROS91_00913	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynPROS91_00914	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynPROS91_00915	COG0012	GTP binding
SynPROS91_00923	COG0601	transmembrane transport
SynPROS91_00926	COG0460	homoserine dehydrogenase
SynPROS91_00927	COG2166	iron-sulfur cluster assembly
SynPROS91_00929	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynPROS91_00951	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynPROS91_00952	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynPROS91_00955	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SynPROS91_00956	COG2010	Cytochrome c
SynPROS91_00957	COG0742	ribosomal rna small subunit methyltransferase
SynPROS91_00958	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynPROS91_00959	COG3118	belongs to the thioredoxin family
SynPROS91_00960	COG0516	GMP reductase activity
SynPROS91_00962	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynPROS91_00963	COG0644	oxidoreductase
SynPROS91_00964	COG1543	Belongs to the glycosyl hydrolase 57 family
SynPROS91_00966	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynPROS91_00967	COG0395	ABC-type sugar transport system, permease component
SynPROS91_00972	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynPROS91_00981	COG1480	7TM receptor with intracellular HD hydrolase
SynPROS91_00982	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynPROS91_00983	COG0142	geranyltranstransferase activity
SynPROS91_00996	COG0406	alpha-ribazole phosphatase activity
SynPROS91_00997	COG1254	Belongs to the acylphosphatase family
SynPROS91_00998	COG1797	cobyrinic acid a,c-diamide synthase activity
SynPROS91_00999	COG3429	Glucose-6-phosphate dehydrogenase subunit
SynPROS91_00999	COG3409	Peptidoglycan-binding domain 1 protein
SynPROS91_01000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynPROS91_01006	COG2205	protein histidine kinase activity
SynPROS91_01009	COG0308	aminopeptidase N
SynPROS91_01011	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynPROS91_01016	COG1640	4-alpha-glucanotransferase
SynPROS91_01018	COG1187	pseudouridine synthase activity
SynPROS91_01019	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROS91_01021	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynPROS91_01023	COG1982	Orn Lys Arg decarboxylase major
SynPROS91_01024	COG0575	Belongs to the CDS family
SynPROS91_01026	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SynPROS91_01026	COG2226	methyltransferase
SynPROS91_01026	COG0596	Alpha beta hydrolase
SynPROS91_01027	COG0371	Dehydrogenase
SynPROS91_01028	COG0542	response to heat
SynPROS91_01029	COG0456	acetyltransferase
SynPROS91_01030	COG0019	diaminopimelate decarboxylase activity
SynPROS91_01031	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynPROS91_01032	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynPROS91_01033	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynPROS91_01034	COG1054	Belongs to the UPF0176 family
SynPROS91_01037	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynPROS91_01038	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynPROS91_01041	COG0475	glutathione-regulated potassium exporter activity
SynPROS91_01041	COG0589	response to stress
SynPROS91_01042	COG1132	(ABC) transporter
SynPROS91_01044	COG0724	RNA recognition motif
SynPROS91_01046	COG0513	Belongs to the DEAD box helicase family
SynPROS91_01048	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynPROS91_01050	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynPROS91_01070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynPROS91_01087	COG0745	RESPONSE REGULATOR receiver
SynPROS91_01089	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynPROS91_01091	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynPROS91_01096	COG0745	RESPONSE REGULATOR receiver
SynPROS91_01098	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynPROS91_01099	COG0271	Belongs to the BolA IbaG family
SynPROS91_01102	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynPROS91_01113	COG0735	belongs to the Fur family
SynPROS91_01116	COG1799	cell septum assembly
SynPROS91_01122	COG0420	3'-5' exonuclease activity
SynPROS91_01128	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynPROS91_01156	COG1126	abc transporter atp-binding protein
SynPROS91_01157	COG0765	amino acid transport
SynPROS91_01159	COG4597	amino acid ABC transporter
SynPROS91_01160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynPROS91_01162	COG0659	secondary active sulfate transmembrane transporter activity
SynPROS91_01172	COG0799	negative regulation of ribosome biogenesis
SynPROS91_01175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynPROS91_01177	COG1115	amino acid carrier protein
SynPROS91_01179	COG1132	(ABC) transporter
SynPROS91_01181	COG0149	triose-phosphate isomerase activity
SynPROS91_01182	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynPROS91_01184	COG1429	ligase activity, forming nitrogen-metal bonds
SynPROS91_01185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynPROS91_01187	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROS91_01190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynPROS91_01200	COG2205	protein histidine kinase activity
SynPROS91_01201	COG2326	polyphosphate kinase activity
SynPROS91_01215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROS91_01218	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SynPROS91_01221	COG2226	methyltransferase
SynPROS91_01222	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynPROS91_01225	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynPROS91_01226	COG1122	ATPase activity
SynPROS91_01228	COG0052	Belongs to the universal ribosomal protein uS2 family
SynPROS91_01229	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynPROS91_01231	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynPROS91_01232	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynPROS91_01233	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynPROS91_01234	COG0751	glycine-tRNA ligase activity
SynPROS91_01235	COG0644	oxidoreductase
SynPROS91_01241	COG1217	gtp-binding protein TYPA
SynPROS91_01246	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynPROS91_01254	COG0861	Integral membrane protein TerC family
SynPROS91_01258	COG0513	Belongs to the DEAD box helicase family
SynPROS91_01259	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynPROS91_01261	COG0312	modulator of DNA gyrase
SynPROS91_01262	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynPROS91_01265	COG0163	prenyltransferase activity
SynPROS91_01266	COG0557	exoribonuclease II activity
SynPROS91_01268	COG2119	membrane
SynPROS91_01273	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynPROS91_01273	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynPROS91_01277	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynPROS91_01278	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROS91_01279	COG1615	UPF0182 protein
SynPROS91_01281	COG0450	alkyl hydroperoxide reductase
SynPROS91_01284	COG0739	heme binding
SynPROS91_01285	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynPROS91_01295	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynPROS91_01298	COG0557	exoribonuclease II activity
SynPROS91_01299	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynPROS91_01300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynPROS91_01301	COG0072	phenylalanine-tRNA ligase activity
SynPROS91_01301	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynPROS91_01302	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynPROS91_01311	COG2385	sporulation resulting in formation of a cellular spore
SynPROS91_01316	COG1410	methionine synthase
SynPROS91_01316	COG0646	methionine synthase
SynPROS91_01317	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynPROS91_01320	COG0613	PHP domain protein
SynPROS91_01321	COG1981	membrane
SynPROS91_01322	COG3046	protein related to deoxyribodipyrimidine photolyase
SynPROS91_01324	COG0322	excinuclease ABC activity
SynPROS91_01325	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynPROS91_01331	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynPROS91_01333	COG0495	leucyl-tRNA aminoacylation
SynPROS91_01334	COG0166	Belongs to the GPI family
SynPROS91_01339	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynPROS91_01340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynPROS91_01341	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynPROS91_01341	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynPROS91_01342	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynPROS91_01343	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynPROS91_01344	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynPROS91_01346	COG0484	heat shock protein binding
SynPROS91_01347	COG0443	Heat shock 70 kDa protein
SynPROS91_01348	COG0573	inorganic phosphate transmembrane transporter activity
SynPROS91_01349	COG0581	inorganic phosphate transmembrane transporter activity
SynPROS91_01350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynPROS91_01353	COG0483	inositol monophosphate 1-phosphatase activity
SynPROS91_01357	COG0326	Molecular chaperone. Has ATPase activity
SynPROS91_01358	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynPROS91_01359	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynPROS91_01360	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynPROS91_01361	COG1653	transport
SynPROS91_01364	COG3842	ATPase activity
SynPROS91_01369	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynPROS91_01370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynPROS91_01374	COG0469	pyruvate kinase activity
SynPROS91_01375	COG0577	efflux transmembrane transporter activity
SynPROS91_01375	COG1136	(ABC) transporter
SynPROS91_01376	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROS91_01377	COG0740	serine-type endopeptidase activity
SynPROS91_01383	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynPROS91_01384	COG2211	Major facilitator Superfamily
SynPROS91_01390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynPROS91_01391	COG1175	transmembrane transport
SynPROS91_01392	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynPROS91_01399	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SynPROS91_01407	COG0484	heat shock protein binding
SynPROS91_01416	COG2226	methyltransferase
SynPROS91_01417	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynPROS91_01431	COG2124	cytochrome p450
SynPROS91_01432	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SynPROS91_01433	COG1611	Belongs to the LOG family
SynPROS91_01446	COG0681	Belongs to the peptidase S26 family
SynPROS91_01447	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynPROS91_01450	COG1376	ErfK ybiS ycfS ynhG family protein
SynPROS91_01451	COG0297	glycogen (starch) synthase activity
SynPROS91_01453	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynPROS91_01455	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynPROS91_01461	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynPROS91_01463	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROS91_01465	COG3659	wide pore channel activity
SynPROS91_01467	COG3128	pkhd-type hydroxylase
SynPROS91_01468	COG1840	ABC-type Fe3 transport system, periplasmic component
SynPROS91_01469	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynPROS91_01470	COG2045	Belongs to the ComB family
SynPROS91_01473	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynPROS91_01474	COG0142	geranyltranstransferase activity
SynPROS91_01475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynPROS91_01476	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynPROS91_01478	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynPROS91_01479	COG2176	DNA-directed DNA polymerase activity
SynPROS91_01483	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynPROS91_01485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROS91_01486	COG0745	RESPONSE REGULATOR receiver
SynPROS91_01488	COG3659	wide pore channel activity
SynPROS91_01492	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynPROS91_01493	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SynPROS91_01497	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynPROS91_01500	COG0174	glutamine synthetase
SynPROS91_01513	COG0515	serine threonine protein kinase
SynPROS91_01514	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynPROS91_01516	COG0628	permease
SynPROS91_01518	COG0426	domain, Protein
SynPROS91_01518	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynPROS91_01520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynPROS91_01521	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynPROS91_01522	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynPROS91_01522	COG0022	dehydrogenase e1 component
SynPROS91_01525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynPROS91_01526	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynPROS91_01527	COG0572	uridine kinase
SynPROS91_01532	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynPROS91_01537	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynPROS91_01544	COG0358	DNA primase activity
SynPROS91_01554	COG0632	four-way junction helicase activity
SynPROS91_01555	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynPROS91_01557	COG0587	DNA-directed DNA polymerase activity
SynPROS91_01558	COG0154	amidase activity
SynPROS91_01560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynPROS91_01561	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynPROS91_01562	COG1366	Belongs to the anti-sigma-factor antagonist family
SynPROS91_01563	COG0505	Belongs to the CarA family
SynPROS91_01564	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynPROS91_01566	COG1132	(ABC) transporter
SynPROS91_01569	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynPROS91_01580	COG0612	Peptidase, M16
SynPROS91_01588	COG1216	Glycosyl transferase, family 2
SynPROS91_01589	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SynPROS91_01591	COG1836	PFAM Integral membrane protein DUF92
SynPROS91_01594	COG3639	organic phosphonate transmembrane transporter activity
SynPROS91_01595	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynPROS91_01595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynPROS91_01596	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynPROS91_01597	COG0436	Aminotransferase
SynPROS91_01600	COG1573	uracil-dna glycosylase
SynPROS91_01601	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynPROS91_01602	COG0793	Belongs to the peptidase S41A family
SynPROS91_01605	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynPROS91_01609	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynPROS91_01610	COG1494	fructose-1,6-bisphosphatase
SynPROS91_01611	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynPROS91_01613	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROS91_01614	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynPROS91_01615	COG0363	glucosamine-6-phosphate deaminase activity
SynPROS91_01618	COG0129	dihydroxy-acid dehydratase activity
SynPROS91_01620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynPROS91_01627	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynPROS91_01628	COG0047	phosphoribosylformylglycinamidine synthase activity
SynPROS91_01629	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynPROS91_01630	COG0191	fructose-bisphosphate aldolase activity
SynPROS91_01631	COG3588	fructose-bisphosphate aldolase
SynPROS91_01632	COG0673	inositol 2-dehydrogenase activity
SynPROS91_01634	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynPROS91_01635	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynPROS91_01637	COG3954	Phosphoribulokinase
SynPROS91_01638	COG0473	3-isopropylmalate dehydrogenase activity
SynPROS91_01639	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynPROS91_01640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynPROS91_01643	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynPROS91_01646	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynPROS91_01647	COG2197	response regulator
SynPROS91_01649	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynPROS91_01652	COG0517	IMP dehydrogenase activity
SynPROS91_01659	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROS91_01669	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynPROS91_01671	COG1121	(ABC) transporter
SynPROS91_01674	COG0701	Predicted permease
SynPROS91_01675	COG2010	Cytochrome c
SynPROS91_01678	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynPROS91_01679	COG1121	(ABC) transporter
SynPROS91_01693	COG2032	superoxide dismutase activity
SynPROS91_01734	COG0300	oxidoreductase activity
SynPROS91_01739	COG0730	response to heat
SynPROS91_01762	COG1064	alcohol dehydrogenase
SynPROS91_01771	COG3781	membrane
SynPROS91_01779	COG0500	methyltransferase
SynPROS91_01786	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynPROS91_01787	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROS91_01797	COG0180	Tryptophanyl-tRNA synthetase
SynPROS91_01800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynPROS91_01802	COG0837	glucose binding
SynPROS91_01803	COG0083	homoserine kinase activity
SynPROS91_01804	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS91_01805	COG0339	signal peptide processing
SynPROS91_01808	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SynPROS91_01809	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynPROS91_01817	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynPROS91_01818	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynPROS91_01820	COG3794	PFAM blue (type 1) copper domain protein
SynPROS91_01829	COG0542	response to heat
SynPROS91_01831	COG0140	phosphoribosyl-ATP diphosphatase activity
SynPROS91_01831	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynPROS91_01834	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROS91_01843	COG0159	tryptophan synthase activity
SynPROS91_01847	COG0418	dihydroorotase activity
SynPROS91_01848	COG0659	secondary active sulfate transmembrane transporter activity
SynPROS91_01850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynPROS91_01853	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynPROS91_01854	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynPROS91_01857	COG0456	acetyltransferase
SynPROS91_01859	COG1132	(ABC) transporter
SynPROS91_01860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynPROS91_01861	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynPROS91_01862	COG3842	ATPase activity
SynPROS91_01863	COG0251	oxidation-reduction process
SynPROS91_01868	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS91_01869	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynPROS91_01870	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynPROS91_01875	COG4451	ribulose bisphosphate carboxylase, small
SynPROS91_01876	COG1850	ribulose-bisphosphate carboxylase activity
SynPROS91_01877	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynPROS91_01879	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynPROS91_01880	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynPROS91_01883	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynPROS91_01884	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynPROS91_01885	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynPROS91_01891	COG0730	response to heat
SynPROS91_01892	COG0095	Lipoate-protein ligase
SynPROS91_01893	COG0517	IMP dehydrogenase activity
SynPROS91_01893	COG1994	Peptidase M50
SynPROS91_01894	COG0135	phosphoribosylanthranilate isomerase activity
SynPROS91_01896	COG0302	gtp cyclohydrolase
SynPROS91_01898	COG0825	malonyl-CoA metabolic process
SynPROS91_01899	COG5322	oxidoreductase activity
SynPROS91_01900	COG3396	Phenylacetate-CoA oxygenase
SynPROS91_01902	COG0539	negative regulation of cytoplasmic translation
SynPROS91_01905	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynPROS91_01909	COG0028	Belongs to the TPP enzyme family
SynPROS91_01910	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROS91_01911	COG0582	viral genome integration into host DNA
SynPROS91_01912	COG2226	methyltransferase
SynPROS91_01914	COG0528	UMP kinase activity
SynPROS91_01915	COG0233	cytoplasmic translational termination
SynPROS91_01916	COG0644	oxidoreductase
SynPROS91_01917	COG0415	Belongs to the DNA photolyase family
SynPROS91_01918	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynPROS91_01919	COG0768	penicillin binding
SynPROS91_01923	COG0588	phosphoglycerate mutase activity
SynPROS91_01924	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SynPROS91_01925	COG0681	Belongs to the peptidase S26 family
SynPROS91_01929	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynPROS91_01933	COG0442	prolyl-tRNA aminoacylation
SynPROS91_01935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynPROS91_01936	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynPROS91_01939	COG0629	single-stranded DNA binding
SynPROS91_01942	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynPROS91_01944	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynPROS91_01946	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROS91_01949	COG0181	hydroxymethylbilane synthase activity
SynPROS91_01954	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynPROS91_01955	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynPROS91_01959	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynPROS91_01960	COG0523	cobalamin synthesis protein
SynPROS91_01966	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynPROS91_01972	COG0277	FAD linked oxidase domain protein
SynPROS91_01973	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynPROS91_01974	COG0405	Gamma-glutamyltransferase
SynPROS91_01975	COG1666	GTP binding
SynPROS91_02000	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynPROS91_02006	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynPROS91_02007	COG1218	3'(2'),5'-bisphosphate nucleotidase
SynPROS91_02008	COG1185	polyribonucleotide nucleotidyltransferase activity
SynPROS91_02010	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynPROS91_02011	COG0750	zinc metalloprotease
SynPROS91_02012	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynPROS91_02014	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROS91_02016	COG0706	membrane insertase activity
SynPROS91_02018	COG0594	ribonuclease P activity
SynPROS91_02020	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynPROS91_02023	COG0616	signal peptide processing
SynPROS91_02025	COG0697	spore germination
SynPROS91_02026	COG0438	transferase activity, transferring glycosyl groups
SynPROS91_02029	COG1842	Phage shock protein A
SynPROS91_02030	COG3118	belongs to the thioredoxin family
SynPROS91_02031	COG0436	Aminotransferase
SynPROS91_02032	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynPROS91_02032	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynPROS91_02033	COG0739	heme binding
SynPROS91_02034	COG0745	RESPONSE REGULATOR receiver
SynPROS91_02035	COG0577	efflux transmembrane transporter activity
SynPROS91_02035	COG1136	(ABC) transporter
SynPROS91_02036	COG1007	ATP synthesis coupled electron transport
SynPROS91_02037	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynPROS91_02041	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynPROS91_02048	COG1845	cytochrome c oxidase, subunit III
SynPROS91_02049	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynPROS91_02051	COG1612	heme a metabolic process
SynPROS91_02053	COG0109	protoheme IX farnesyltransferase activity
SynPROS91_02057	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynPROS91_02059	COG0459	protein refolding
SynPROS91_02061	COG1028	Short-chain dehydrogenase reductase Sdr
SynPROS91_02063	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynPROS91_02065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynPROS91_02066	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynPROS91_02067	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynPROS91_02068	COG0248	Ppx GppA phosphatase
SynPROS91_02072	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynPROS91_02073	COG0739	heme binding
SynPROS91_02074	COG0723	plastoquinol--plastocyanin reductase activity
SynPROS91_02076	COG0805	protein transport
SynPROS91_02077	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynPROS91_02078	COG0194	GDP metabolic process
SynPROS91_02081	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynPROS91_02082	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROS91_02087	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynPROS91_02092	COG0335	large ribosomal subunit rRNA binding
SynPROS91_02094	COG0024	Methionine aminopeptidase
SynPROS91_02095	COG0300	oxidoreductase activity
SynPROS91_02095	COG3000	fatty acid hydroxylase
SynPROS91_02096	COG0857	belongs to the CobB CobQ family
SynPROS91_02116	COG0776	regulation of translation
SynPROS91_02121	COG2211	Major facilitator Superfamily
SynPROS91_02122	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynPROS91_02125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynPROS91_02126	COG0284	orotidine-5'-phosphate decarboxylase activity
SynPROS91_02127	COG3386	PFAM SMP-30 Gluconolaconase
SynPROS91_02129	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynPROS91_02134	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynPROS91_02136	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynPROS91_02138	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynPROS91_02139	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynPROS91_02140	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynPROS91_02142	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynPROS91_02144	COG0151	Belongs to the GarS family
SynPROS91_02145	COG5002	protein histidine kinase activity
SynPROS91_02146	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynPROS91_02147	COG4251	negative regulation of phosphorylation
SynPROS91_02149	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynPROS91_02150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynPROS91_02163	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynPROS91_02164	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynPROS91_02165	COG0217	transcriptional regulatory protein
SynPROS91_02184	COG0363	glucosamine-6-phosphate deaminase activity
SynPROS91_02185	COG2385	sporulation resulting in formation of a cellular spore
SynPROS91_02186	COG1234	tRNA 3'-trailer cleavage
SynPROS91_02187	COG2010	Cytochrome c
SynPROS91_02193	COG2264	protein methyltransferase activity
SynPROS91_02194	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynPROS91_02199	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynPROS91_02210	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynPROS91_02214	COG0459	protein refolding
SynPROS91_02215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynPROS91_02216	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynPROS91_02217	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynPROS91_02222	COG0006	proline dipeptidase activity
SynPROS91_02223	COG1253	flavin adenine dinucleotide binding
SynPROS91_02224	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynPROS91_02225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynPROS91_02227	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynPROS91_02227	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynPROS91_02228	COG0686	Belongs to the AlaDH PNT family
SynPROS91_02233	COG3012	SEC-C Motif Domain Protein
SynPROS91_02234	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynPROS91_02236	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynPROS91_02238	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynPROS91_02239	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynPROS91_02240	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynPROS91_02241	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynPROS91_02242	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynPROS91_02243	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynPROS91_02244	COG0356	it plays a direct role in the translocation of protons across the membrane
SynPROS91_02246	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynPROS91_02247	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROS91_02251	COG0772	Belongs to the SEDS family
SynPROS91_02253	COG1333	cytochrome c biogenesis protein
SynPROS91_02254	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynPROS91_02256	COG0347	Belongs to the P(II) protein family
SynPROS91_02259	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynPROS91_02260	COG0114	fumarate hydratase activity
SynPROS91_02261	COG4581	dead DEAH box helicase
SynPROS91_02262	COG0156	8-amino-7-oxononanoate synthase activity
SynPROS91_02264	COG2226	methyltransferase
SynPROS91_02265	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynPROS91_02267	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynPROS91_02270	COG0357	Ribosomal RNA small subunit methyltransferase G
SynPROS91_02277	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SynPROS91_02278	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynPROS91_02281	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynPROS91_02282	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynPROS91_02283	COG0085	RNA polymerase activity
SynPROS91_02285	COG0084	hydrolase, TatD family'
SynPROS91_02286	COG0268	Binds directly to 16S ribosomal RNA
SynPROS91_02287	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynPROS91_02288	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynPROS91_02289	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynPROS91_02292	COG0779	Required for maturation of 30S ribosomal subunits
SynPROS91_02293	COG0195	Participates in both transcription termination and antitermination
SynPROS91_02295	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynPROS91_02308	COG2988	succinylglutamate desuccinylase activity
SynPROS91_02309	COG0435	Glutathione S-transferase
SynPROS91_02311	COG0488	(ABC) transporter
SynPROS91_02314	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynPROS91_02315	COG3842	ATPase activity
SynPROS91_02316	COG1193	negative regulation of DNA recombination
SynPROS91_02318	COG0113	porphobilinogen synthase activity
SynPROS91_02319	COG0484	heat shock protein binding
SynPROS91_02321	COG0659	secondary active sulfate transmembrane transporter activity
SynPROS91_02417	COG0116	Belongs to the methyltransferase superfamily
SynPROS91_02421	COG1196	nuclear chromosome segregation
SynPROS91_02423	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynPROS91_02426	COG0439	Biotin carboxylase
SynPROS91_02429	COG0515	serine threonine protein kinase
SynPROS91_02432	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROS91_02433	COG4178	(ABC) transporter
SynPROS91_02434	COG0537	adenosine 5'-monophosphoramidase activity
SynPROS91_02437	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynPROS91_02440	COG0242	peptide deformylase activity
SynPROS91_02442	COG0235	Class ii aldolase
SynPROS91_02443	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynPROS91_02445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynPROS91_02446	COG0719	Fe-S assembly protein
SynPROS91_02447	COG0396	ATPase activity
SynPROS91_02448	COG0719	Fe-S assembly protein
SynPROS91_02449	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynPROS91_02453	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROS91_02458	COG0033	Phosphoglucomutase
SynPROS91_02461	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynPROS91_02467	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynPROS91_02468	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynPROS91_02469	COG0175	sulfate reduction
SynPROS91_02470	COG1252	NADH dehydrogenase
SynPROS91_02471	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynPROS91_02473	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynPROS91_02474	COG0569	domain protein
SynPROS91_02475	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynPROS91_02481	COG0488	(ABC) transporter
SynPROS91_02483	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynPROS91_02486	COG1643	Atp-dependent helicase
SynPROS91_02489	COG1570	exodeoxyribonuclease VII activity
SynPROS91_02490	COG1722	exodeoxyribonuclease VII activity
SynPROS91_02499	COG0483	inositol monophosphate 1-phosphatase activity
SynPROS91_02500	COG1538	Outer membrane efflux protein
SynPROS91_02502	COG1968	undecaprenyl-diphosphatase activity
SynPROS91_02504	COG1555	photosystem II stabilization
SynPROS91_02505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynPROS91_02506	COG4243	Vitamin k epoxide reductase
SynPROS91_02508	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynPROS91_02511	COG1032	radical SAM domain protein
SynPROS91_02523	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynPROS91_02525	COG0457	Tetratricopeptide repeat
SynPROS91_02525	COG0463	Glycosyl transferase, family 2
SynPROS91_02526	COG1587	Uroporphyrinogen-III synthase
SynPROS91_02529	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynPROS91_02530	COG0316	Belongs to the HesB IscA family
SynPROS91_02533	COG1090	epimerase
SynPROS91_02537	COG0484	heat shock protein binding
SynPROS91_02538	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynPROS91_02539	COG3659	wide pore channel activity
SynPROS91_02550	COG1122	ATPase activity
SynPROS91_02552	COG0745	RESPONSE REGULATOR receiver
SynPROS91_02554	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynPROS91_02555	COG2217	Heavy metal translocating P-type atpase
SynPROS91_02556	COG3063	Type IV pilus biogenesis stability protein PilW
SynPROS91_02557	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynPROS91_02559	COG0416	fatty acid biosynthetic process
SynPROS91_02560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynPROS91_02561	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynPROS91_02564	COG1214	PFAM Peptidase M22, glycoprotease
SynPROS91_02566	COG0617	tRNA 3'-terminal CCA addition
SynPROS91_02568	COG1562	ergosterol biosynthetic process
SynPROS91_02569	COG0493	'glutamate synthase
SynPROS91_02569	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynPROS91_02572	COG0583	DNA-binding transcription factor activity
SynPROS91_02574	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynPROS91_02575	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS91_02578	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynPROS91_02580	COG2197	response regulator
SynPROS91_02583	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynPROS91_02584	COG0713	ATP synthesis coupled electron transport
SynPROS91_02585	COG0839	Belongs to the complex I subunit 6 family
SynPROS91_02586	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROS91_02587	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynPROS91_02588	COG0372	Belongs to the citrate synthase family
SynPROS91_02592	COG1420	regulation of RNA biosynthetic process
SynPROS91_02593	COG0133	tryptophan synthase activity
SynPROS91_02596	COG0529	Catalyzes the synthesis of activated sulfate
SynPROS91_02597	COG0628	permease
SynPROS91_02598	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynPROS91_02600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynPROS91_02601	COG0564	pseudouridine synthase activity
SynPROS91_02602	COG0745	RESPONSE REGULATOR receiver
SynPROS91_02608	COG0275	rRNA processing
SynPROS91_02609	COG0649	NAD binding
SynPROS91_02610	COG0824	Thioesterase
SynPROS91_02612	COG4948	Mandelate Racemase Muconate Lactonizing
SynPROS91_02613	COG1575	Belongs to the MenA family. Type 1 subfamily
SynPROS91_02614	COG1169	isochorismate synthase
SynPROS91_02615	COG0189	ligase activity
SynPROS91_02616	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynPROS91_02617	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynPROS91_02619	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynPROS91_02620	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynPROS91_02623	COG0252	asparaginase activity
SynPROS91_02624	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynPROS91_02625	COG0018	arginyl-trna synthetase
SynPROS91_02626	COG0157	Belongs to the NadC ModD family
SynPROS91_02627	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynPROS91_02629	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SynPROS91_02630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynPROS91_02631	COG4172	Belongs to the ABC transporter superfamily
SynPROS91_02632	COG0564	pseudouridine synthase activity
SynPROS91_02634	COG0589	response to stress
SynPROS91_02635	COG0126	phosphoglycerate kinase activity
SynPROS91_02638	COG2084	Dehydrogenase
SynPROS91_02640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynPROS91_02641	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynPROS91_02647	COG0167	dihydroorotate dehydrogenase activity
SynPROS91_02648	COG0328	RNA-DNA hybrid ribonuclease activity
SynPROS91_02651	COG0222	ribosome binding
SynPROS91_02652	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynPROS91_02653	COG0081	regulation of translation
SynPROS91_02654	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynPROS91_02655	COG0250	Participates in transcription elongation, termination and antitermination
SynPROS91_02656	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynPROS91_02657	COG0542	response to heat
SynPROS91_02658	COG0346	lactoylglutathione lyase activity
SynPROS91_02659	COG0148	phosphopyruvate hydratase activity
SynPROS91_02661	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynPROS91_02664	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynPROS91_02665	COG0237	dephospho-CoA kinase activity
SynPROS91_02669	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynPROS91_02670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynPROS91_02670	COG2022	thiamine diphosphate biosynthetic process
SynPROS91_02671	COG0105	UTP biosynthetic process
SynPROS91_02672	COG1166	arginine decarboxylase activity
SynPROS91_02674	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynPROS91_02676	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynPROS91_02681	COG0071	Belongs to the small heat shock protein (HSP20) family
SynPROS91_02683	COG0426	domain, Protein
SynPROS91_02683	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynPROS91_02684	COG0426	domain, Protein
SynPROS91_02684	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynPROS91_02685	COG1773	rubredoxin
SynPROS91_02691	COG0509	glycine decarboxylation via glycine cleavage system
SynPROS91_02692	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynPROS91_02696	COG0359	binds to the 23S rRNA
SynPROS91_02697	COG0305	Participates in initiation and elongation during chromosome replication
SynPROS91_02697	COG1372	Participates in initiation and elongation during chromosome replication
SynPROS91_02697	COG0305	Participates in initiation and elongation during chromosome replication
SynPROS91_02697	COG1372	Participates in initiation and elongation during chromosome replication
SynPROS91_02698	COG0445	tRNA wobble uridine modification
SynPROS91_02709	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynPROS91_02711	COG0398	Pfam SNARE associated Golgi protein
SynPROS91_02714	COG1131	(ABC) transporter
SynPROS91_02715	COG0525	valine-tRNA ligase activity
SynPROS91_02720	COG1028	Short-chain dehydrogenase reductase Sdr
SynPROS91_02732	COG3956	TIGRFAM MazG family protein
SynPROS91_02733	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynPROS91_02734	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynPROS91_02735	COG0010	Belongs to the arginase family
SynPROS91_02738	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynPROS91_02739	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynPROS91_02740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROS91_02743	COG0504	CTP synthase activity
SynPROS91_02744	COG0602	queuosine metabolic process
SynPROS91_02745	COG4574	serine-type endopeptidase inhibitor activity
SynPROS91_02746	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynPROS91_02755	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynPROS91_02756	COG0830	nickel cation binding
SynPROS91_02757	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynPROS91_02759	COG0829	nickel cation binding
SynPROS91_02760	COG0831	urea catabolic process
SynPROS91_02761	COG0832	Belongs to the urease beta subunit family
SynPROS91_02762	COG0804	urea catabolic process
SynPROS91_02766	COG2308	Evidence 4 Homologs of previously reported genes of
SynPROS91_02770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynPROS91_02773	COG2223	nitrite transmembrane transporter activity
SynPROS91_02774	COG0243	molybdopterin cofactor binding
SynPROS91_02778	COG0315	cyclic pyranopterin monophosphate synthase activity
SynPROS91_02780	COG0314	molybdopterin synthase activity
SynPROS91_02782	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynPROS91_02783	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynPROS91_02786	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynPROS91_02788	COG2116	formate transmembrane transporter activity
SynPROS91_02790	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynPROS91_02792	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynPROS91_02794	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynPROS91_02795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROS91_02796	COG0170	dolichyl monophosphate biosynthetic process
SynPROS91_02797	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynPROS91_02799	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynPROS91_02801	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynPROS91_02803	COG0788	formyltetrahydrofolate deformylase activity
SynPROS91_02805	COG2022	thiamine diphosphate biosynthetic process
SynPROS91_02805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynPROS91_02807	COG0443	Heat shock 70 kDa protein
SynPROS91_02808	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynPROS91_02810	COG0360	Binds together with S18 to 16S ribosomal RNA
SynPROS91_02812	COG0137	argininosuccinate synthase activity
SynPROS91_02815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynPROS91_02820	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynPROS91_02821	COG0438	transferase activity, transferring glycosyl groups
SynPROS91_02823	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynPROS91_02824	COG0497	DNA recombination
SynPROS91_02825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynPROS91_02827	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine