locus-tag	class	description
SynPROSU1_00001	COG0592	DNA-directed DNA polymerase activity
SynPROSU1_00003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynPROSU1_00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynPROSU1_00007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynPROSU1_00010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynPROSU1_00012	COG0552	protein localization to endoplasmic reticulum
SynPROSU1_00013	COG2208	phosphoserine phosphatase activity
SynPROSU1_00014	COG0165	Argininosuccinate lyase
SynPROSU1_00015	COG0724	RNA recognition motif
SynPROSU1_00016	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynPROSU1_00018	COG2081	HI0933 family
SynPROSU1_00019	COG1459	type II secretion system
SynPROSU1_00021	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynPROSU1_00022	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynPROSU1_00023	COG0484	heat shock protein binding
SynPROSU1_00025	COG1162	GTPase activity
SynPROSU1_00026	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynPROSU1_00027	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynPROSU1_00028	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynPROSU1_00029	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynPROSU1_00030	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynPROSU1_00031	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynPROSU1_00032	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynPROSU1_00033	COG0511	ligase activity, forming carbon-carbon bonds
SynPROSU1_00034	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynPROSU1_00049	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynPROSU1_00050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynPROSU1_00050	COG0519	Catalyzes the synthesis of GMP from XMP
SynPROSU1_00054	COG0768	penicillin binding
SynPROSU1_00056	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynPROSU1_00056	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_00057	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynPROSU1_00059	COG2022	thiamine diphosphate biosynthetic process
SynPROSU1_00062	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynPROSU1_00063	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynPROSU1_00064	COG2385	sporulation resulting in formation of a cellular spore
SynPROSU1_00065	COG1215	transferase activity, transferring glycosyl groups
SynPROSU1_00066	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynPROSU1_00068	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynPROSU1_00069	COG0740	serine-type endopeptidase activity
SynPROSU1_00070	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynPROSU1_00071	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynPROSU1_00072	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynPROSU1_00073	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynPROSU1_00083	COG2082	Precorrin-8x methylmutase
SynPROSU1_00086	COG0037	tRNA processing
SynPROSU1_00089	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynPROSU1_00093	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynPROSU1_00096	COG0556	nucleotide-excision repair
SynPROSU1_00097	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynPROSU1_00100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynPROSU1_00104	COG0436	Aminotransferase
SynPROSU1_00105	COG0028	Belongs to the TPP enzyme family
SynPROSU1_00106	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynPROSU1_00121	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_00136	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynPROSU1_00146	COG0653	protein targeting
SynPROSU1_00149	COG1045	serine acetyltransferase
SynPROSU1_00150	COG1725	Transcriptional regulator
SynPROSU1_00153	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynPROSU1_00154	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynPROSU1_00155	COG0187	DNA topoisomerase II activity
SynPROSU1_00155	COG1372	Participates in initiation and elongation during chromosome replication
SynPROSU1_00157	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynPROSU1_00158	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynPROSU1_00160	COG0386	Belongs to the glutathione peroxidase family
SynPROSU1_00161	COG2239	Acts as a magnesium transporter
SynPROSU1_00162	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROSU1_00163	COG0596	Alpha beta hydrolase
SynPROSU1_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynPROSU1_00179	COG1194	a g-specific adenine glycosylase
SynPROSU1_00183	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynPROSU1_00184	COG0586	Pfam SNARE associated Golgi protein
SynPROSU1_00185	COG0629	single-stranded DNA binding
SynPROSU1_00187	COG1792	Involved in formation and maintenance of cell shape
SynPROSU1_00191	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynPROSU1_00195	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynPROSU1_00196	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynPROSU1_00197	COG0515	serine threonine protein kinase
SynPROSU1_00198	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynPROSU1_00199	COG2255	four-way junction helicase activity
SynPROSU1_00201	COG1473	amidohydrolase
SynPROSU1_00204	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynPROSU1_00205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynPROSU1_00206	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynPROSU1_00207	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynPROSU1_00208	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_00209	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynPROSU1_00210	COG0662	Cupin 2, conserved barrel domain protein
SynPROSU1_00210	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynPROSU1_00211	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynPROSU1_00213	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROSU1_00214	COG0571	ribonuclease III activity
SynPROSU1_00218	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SynPROSU1_00219	COG0058	SHG alpha-glucan phosphorylase activity
SynPROSU1_00220	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SynPROSU1_00221	COG0475	glutathione-regulated potassium exporter activity
SynPROSU1_00225	COG0277	FAD linked oxidase domain protein
SynPROSU1_00227	COG0247	lactate metabolic process
SynPROSU1_00228	COG0538	isocitrate dehydrogenase activity
SynPROSU1_00229	COG0463	Glycosyl transferase, family 2
SynPROSU1_00231	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SynPROSU1_00233	COG5398	heme oxygenase
SynPROSU1_00236	COG1132	(ABC) transporter
SynPROSU1_00237	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_00238	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_00239	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_00240	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_00243	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynPROSU1_00249	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynPROSU1_00250	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SynPROSU1_00251	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynPROSU1_00252	COG0517	IMP dehydrogenase activity
SynPROSU1_00252	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SynPROSU1_00253	COG0517	IMP dehydrogenase activity
SynPROSU1_00253	COG0617	tRNA 3'-terminal CCA addition
SynPROSU1_00253	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SynPROSU1_00255	COG0709	Synthesizes selenophosphate from selenide and ATP
SynPROSU1_00256	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynPROSU1_00259	COG2274	protein secretion by the type I secretion system
SynPROSU1_00262	COG0124	histidyl-tRNA synthetase
SynPROSU1_00264	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynPROSU1_00270	COG4447	cellulose binding
SynPROSU1_00271	COG1773	rubredoxin
SynPROSU1_00272	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_00273	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_00274	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_00275	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynPROSU1_00276	COG3842	ATPase activity
SynPROSU1_00278	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynPROSU1_00278	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynPROSU1_00281	COG0494	nUDIX hydrolase
SynPROSU1_00282	COG0415	Belongs to the DNA photolyase family
SynPROSU1_00288	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynPROSU1_00289	COG0131	Imidazoleglycerol-phosphate dehydratase
SynPROSU1_00290	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynPROSU1_00294	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynPROSU1_00298	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynPROSU1_00299	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynPROSU1_00301	COG0354	folic acid binding
SynPROSU1_00302	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynPROSU1_00305	COG1253	flavin adenine dinucleotide binding
SynPROSU1_00306	COG0673	inositol 2-dehydrogenase activity
SynPROSU1_00308	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SynPROSU1_00310	COG0343	queuine tRNA-ribosyltransferase activity
SynPROSU1_00312	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SynPROSU1_00317	COG0138	bifunctional purine biosynthesis protein purh
SynPROSU1_00322	COG0716	FMN binding
SynPROSU1_00327	COG0351	phosphomethylpyrimidine kinase
SynPROSU1_00329	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynPROSU1_00330	COG0004	ammonium transporteR
SynPROSU1_00331	COG1489	DNA binding
SynPROSU1_00332	COG0728	peptidoglycan biosynthetic process
SynPROSU1_00338	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynPROSU1_00339	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynPROSU1_00340	COG1058	Belongs to the CinA family
SynPROSU1_00340	COG1546	Belongs to the CinA family
SynPROSU1_00341	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynPROSU1_00342	COG0066	3-isopropylmalate dehydratase activity
SynPROSU1_00349	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynPROSU1_00350	COG0193	aminoacyl-tRNA hydrolase activity
SynPROSU1_00353	COG4372	Transposase
SynPROSU1_00354	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROSU1_00355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynPROSU1_00357	COG0717	Belongs to the dCTP deaminase family
SynPROSU1_00359	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynPROSU1_00361	COG0741	lytic transglycosylase activity
SynPROSU1_00363	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynPROSU1_00366	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynPROSU1_00370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynPROSU1_00374	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynPROSU1_00375	COG1402	creatininase
SynPROSU1_00377	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynPROSU1_00378	COG2094	Belongs to the DNA glycosylase MPG family
SynPROSU1_00379	COG0540	Belongs to the ATCase OTCase family
SynPROSU1_00385	COG3536	Protein conserved in bacteria
SynPROSU1_00386	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynPROSU1_00389	COG2046	Belongs to the sulfate adenylyltransferase family
SynPROSU1_00389	COG0529	Catalyzes the synthesis of activated sulfate
SynPROSU1_00390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROSU1_00393	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynPROSU1_00400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynPROSU1_00403	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynPROSU1_00404	COG0436	Aminotransferase
SynPROSU1_00407	COG1530	ribonuclease E activity
SynPROSU1_00408	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynPROSU1_00411	COG2226	methyltransferase
SynPROSU1_00412	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynPROSU1_00413	COG0051	transcription antitermination factor activity, RNA binding
SynPROSU1_00414	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynPROSU1_00415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynPROSU1_00416	COG0049	tRNA binding
SynPROSU1_00417	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynPROSU1_00421	COG0067	glutamate synthase
SynPROSU1_00421	COG0069	glutamate synthase activity
SynPROSU1_00421	COG0070	glutamate synthase
SynPROSU1_00425	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynPROSU1_00433	COG2885	chlorophyll binding
SynPROSU1_00434	COG2885	chlorophyll binding
SynPROSU1_00444	COG0463	Glycosyl transferase, family 2
SynPROSU1_00451	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynPROSU1_00453	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynPROSU1_00454	COG0254	rRNA binding
SynPROSU1_00455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynPROSU1_00456	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynPROSU1_00457	COG0101	tRNA pseudouridine synthase activity
SynPROSU1_00458	COG0203	ribosomal protein L17
SynPROSU1_00459	COG0202	RNA polymerase activity
SynPROSU1_00460	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynPROSU1_00461	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynPROSU1_00462	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynPROSU1_00463	COG0563	adenylate kinase activity
SynPROSU1_00464	COG0201	protein transport
SynPROSU1_00465	COG0200	Binds to the 23S rRNA
SynPROSU1_00466	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynPROSU1_00467	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynPROSU1_00468	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynPROSU1_00469	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynPROSU1_00470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynPROSU1_00471	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynPROSU1_00472	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynPROSU1_00473	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynPROSU1_00474	COG0255	Belongs to the universal ribosomal protein uL29 family
SynPROSU1_00475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynPROSU1_00476	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynPROSU1_00477	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynPROSU1_00478	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynPROSU1_00479	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynPROSU1_00480	COG0089	rRNA binding
SynPROSU1_00481	COG0088	Forms part of the polypeptide exit tunnel
SynPROSU1_00482	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynPROSU1_00485	COG3854	ATPases associated with a variety of cellular activities
SynPROSU1_00488	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynPROSU1_00494	COG3001	Fructosamine kinase
SynPROSU1_00498	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynPROSU1_00499	COG1606	tRNA processing
SynPROSU1_00500	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynPROSU1_00501	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynPROSU1_00504	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynPROSU1_00505	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynPROSU1_00506	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynPROSU1_00509	COG0772	Belongs to the SEDS family
SynPROSU1_00510	COG0489	protein tyrosine kinase activity
SynPROSU1_00511	COG0408	coproporphyrinogen oxidase activity
SynPROSU1_00515	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SynPROSU1_00523	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynPROSU1_00524	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynPROSU1_00525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynPROSU1_00525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynPROSU1_00526	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynPROSU1_00563	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROSU1_00574	COG1070	Carbohydrate kinase
SynPROSU1_00575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynPROSU1_00576	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynPROSU1_00577	COG0539	negative regulation of cytoplasmic translation
SynPROSU1_00578	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynPROSU1_00583	COG0589	response to stress
SynPROSU1_00585	COG0758	DNA mediated transformation
SynPROSU1_00585	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynPROSU1_00586	COG2890	protein-(glutamine-N5) methyltransferase activity
SynPROSU1_00587	COG0009	L-threonylcarbamoyladenylate synthase
SynPROSU1_00591	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynPROSU1_00592	COG2894	cell division
SynPROSU1_00593	COG0850	regulation of cytokinetic process
SynPROSU1_00594	COG1078	dGTPase activity
SynPROSU1_00595	COG0793	Belongs to the peptidase S41A family
SynPROSU1_00596	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynPROSU1_00597	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynPROSU1_00606	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynPROSU1_00607	COG0235	Class ii aldolase
SynPROSU1_00608	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynPROSU1_00609	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynPROSU1_00612	COG0514	ATP-dependent DNA helicase (RecQ)
SynPROSU1_00613	COG1388	LysM domain
SynPROSU1_00613	COG3584	3D domain protein
SynPROSU1_00614	COG1012	belongs to the aldehyde dehydrogenase family
SynPROSU1_00616	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynPROSU1_00617	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynPROSU1_00621	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynPROSU1_00626	COG0659	secondary active sulfate transmembrane transporter activity
SynPROSU1_00627	COG4243	Vitamin k epoxide reductase
SynPROSU1_00628	COG0484	heat shock protein binding
SynPROSU1_00629	COG0113	porphobilinogen synthase activity
SynPROSU1_00631	COG1193	negative regulation of DNA recombination
SynPROSU1_00637	COG2770	Histidine kinase
SynPROSU1_00637	COG2208	phosphoserine phosphatase activity
SynPROSU1_00647	COG3842	ATPase activity
SynPROSU1_00648	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynPROSU1_00651	COG0488	(ABC) transporter
SynPROSU1_00653	COG0435	Glutathione S-transferase
SynPROSU1_00654	COG2988	succinylglutamate desuccinylase activity
SynPROSU1_00719	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynPROSU1_00721	COG1185	polyribonucleotide nucleotidyltransferase activity
SynPROSU1_00722	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynPROSU1_00723	COG0750	zinc metalloprotease
SynPROSU1_00724	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynPROSU1_00728	COG0706	membrane insertase activity
SynPROSU1_00730	COG0594	ribonuclease P activity
SynPROSU1_00731	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynPROSU1_00734	COG0616	signal peptide processing
SynPROSU1_00735	COG0697	spore germination
SynPROSU1_00737	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynPROSU1_00740	COG1842	Phage shock protein A
SynPROSU1_00741	COG3118	belongs to the thioredoxin family
SynPROSU1_00742	COG0436	Aminotransferase
SynPROSU1_00743	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynPROSU1_00743	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynPROSU1_00744	COG0739	heme binding
SynPROSU1_00745	COG0745	RESPONSE REGULATOR receiver
SynPROSU1_00747	COG2205	protein histidine kinase activity
SynPROSU1_00748	COG1136	(ABC) transporter
SynPROSU1_00748	COG0577	efflux transmembrane transporter activity
SynPROSU1_00749	COG1007	ATP synthesis coupled electron transport
SynPROSU1_00750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynPROSU1_00753	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynPROSU1_00759	COG1845	cytochrome c oxidase, subunit III
SynPROSU1_00760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynPROSU1_00761	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SynPROSU1_00762	COG1612	heme a metabolic process
SynPROSU1_00763	COG0109	protoheme IX farnesyltransferase activity
SynPROSU1_00767	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynPROSU1_00768	COG0459	protein refolding
SynPROSU1_00770	COG1028	Short-chain dehydrogenase reductase Sdr
SynPROSU1_00773	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynPROSU1_00774	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynPROSU1_00775	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynPROSU1_00776	COG0248	Ppx GppA phosphatase
SynPROSU1_00780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynPROSU1_00781	COG0739	heme binding
SynPROSU1_00782	COG0723	plastoquinol--plastocyanin reductase activity
SynPROSU1_00784	COG0805	protein transport
SynPROSU1_00785	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynPROSU1_00786	COG0194	GDP metabolic process
SynPROSU1_00789	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynPROSU1_00790	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROSU1_00792	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynPROSU1_00796	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynPROSU1_00800	COG0335	large ribosomal subunit rRNA binding
SynPROSU1_00802	COG0024	Methionine aminopeptidase
SynPROSU1_00803	COG0300	oxidoreductase activity
SynPROSU1_00803	COG3000	fatty acid hydroxylase
SynPROSU1_00805	COG0857	belongs to the CobB CobQ family
SynPROSU1_00809	COG1666	GTP binding
SynPROSU1_00812	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SynPROSU1_00815	COG0295	cytidine deaminase activity
SynPROSU1_00817	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynPROSU1_00819	COG0277	FAD linked oxidase domain protein
SynPROSU1_00820	COG0708	Exodeoxyribonuclease III
SynPROSU1_00825	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynPROSU1_00829	COG3842	ATPase activity
SynPROSU1_00831	COG0523	cobalamin synthesis protein
SynPROSU1_00832	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynPROSU1_00839	COG0432	Pfam Uncharacterised protein family UPF0047
SynPROSU1_00842	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynPROSU1_00843	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynPROSU1_00846	COG0181	hydroxymethylbilane synthase activity
SynPROSU1_00848	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROSU1_00850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynPROSU1_00852	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynPROSU1_00856	COG2099	Precorrin-6x reductase
SynPROSU1_00858	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynPROSU1_00859	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynPROSU1_00861	COG0442	prolyl-tRNA aminoacylation
SynPROSU1_00864	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynPROSU1_00870	COG0588	phosphoglycerate mutase activity
SynPROSU1_00874	COG0768	penicillin binding
SynPROSU1_00875	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynPROSU1_00878	COG0415	Belongs to the DNA photolyase family
SynPROSU1_00880	COG0233	cytoplasmic translational termination
SynPROSU1_00881	COG0528	UMP kinase activity
SynPROSU1_00886	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROSU1_00887	COG0028	Belongs to the TPP enzyme family
SynPROSU1_00891	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynPROSU1_00895	COG0539	negative regulation of cytoplasmic translation
SynPROSU1_00897	COG3396	Phenylacetate-CoA oxygenase
SynPROSU1_00898	COG5322	oxidoreductase activity
SynPROSU1_00899	COG0825	malonyl-CoA metabolic process
SynPROSU1_00900	COG0300	oxidoreductase activity
SynPROSU1_00902	COG0302	gtp cyclohydrolase
SynPROSU1_00903	COG0135	phosphoribosylanthranilate isomerase activity
SynPROSU1_00904	COG1994	Peptidase M50
SynPROSU1_00904	COG0517	IMP dehydrogenase activity
SynPROSU1_00905	COG0095	Lipoate-protein ligase
SynPROSU1_00906	COG0730	response to heat
SynPROSU1_00912	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynPROSU1_00915	COG1231	oxidoreductase activity
SynPROSU1_00917	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynPROSU1_00918	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynPROSU1_00920	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynPROSU1_00921	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynPROSU1_00923	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynPROSU1_00924	COG1850	ribulose-bisphosphate carboxylase activity
SynPROSU1_00925	COG4451	ribulose bisphosphate carboxylase, small
SynPROSU1_00930	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynPROSU1_00931	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynPROSU1_00932	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_00940	COG1492	cobalamin metabolic process
SynPROSU1_00942	COG0424	maF-like protein
SynPROSU1_00955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynPROSU1_00956	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynPROSU1_00958	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynPROSU1_00967	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynPROSU1_00968	COG0579	oxidoreductase
SynPROSU1_00971	COG0481	GTPase activity
SynPROSU1_00976	COG2165	general secretion pathway protein
SynPROSU1_00980	COG0745	RESPONSE REGULATOR receiver
SynPROSU1_00983	COG4968	Prepilin-type N-terminal cleavage methylation domain
SynPROSU1_00986	COG5002	protein histidine kinase activity
SynPROSU1_00987	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SynPROSU1_00990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynPROSU1_00991	COG0545	Peptidyl-prolyl cis-trans isomerase
SynPROSU1_00992	COG3695	enzyme binding
SynPROSU1_00993	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynPROSU1_00993	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynPROSU1_00994	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynPROSU1_00995	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynPROSU1_00997	COG0107	imidazoleglycerol-phosphate synthase activity
SynPROSU1_00998	COG2226	methyltransferase
SynPROSU1_01000	COG0752	glycyl-tRNA synthetase alpha subunit
SynPROSU1_01008	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynPROSU1_01009	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynPROSU1_01010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynPROSU1_01011	COG0740	serine-type endopeptidase activity
SynPROSU1_01012	COG0740	serine-type endopeptidase activity
SynPROSU1_01013	COG4956	integral membrane protein (PIN domain superfamily)
SynPROSU1_01014	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynPROSU1_01019	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynPROSU1_01020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynPROSU1_01023	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynPROSU1_01024	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynPROSU1_01025	COG4948	Mandelate Racemase Muconate Lactonizing
SynPROSU1_01032	COG0285	dihydrofolate synthase activity
SynPROSU1_01033	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynPROSU1_01034	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynPROSU1_01035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynPROSU1_01038	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynPROSU1_01039	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynPROSU1_01041	COG0134	indole-3-glycerol-phosphate synthase activity
SynPROSU1_01047	COG1007	ATP synthesis coupled electron transport
SynPROSU1_01048	COG1006	Multisubunit Na H antiporter MnhC subunit
SynPROSU1_01054	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynPROSU1_01055	COG0482	sulfurtransferase activity
SynPROSU1_01056	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynPROSU1_01056	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynPROSU1_01057	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROSU1_01058	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynPROSU1_01060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynPROSU1_01061	COG0228	four-way junction DNA binding
SynPROSU1_01062	COG1702	phosphate starvation-inducible protein PhoH
SynPROSU1_01063	COG0670	Belongs to the BI1 family
SynPROSU1_01064	COG0477	Major facilitator Superfamily
SynPROSU1_01066	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynPROSU1_01068	COG0786	glutamate:sodium symporter activity
SynPROSU1_01071	COG0336	Belongs to the RNA methyltransferase TrmD family
SynPROSU1_01073	COG1691	(AIR) carboxylase
SynPROSU1_01078	COG0352	thiamine-phosphate diphosphorylase activity
SynPROSU1_01080	COG0196	riboflavin kinase activity
SynPROSU1_01085	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynPROSU1_01086	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynPROSU1_01090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynPROSU1_01091	COG0745	RESPONSE REGULATOR receiver
SynPROSU1_01099	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynPROSU1_01099	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynPROSU1_01110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynPROSU1_01120	COG2135	peptidase activity
SynPROSU1_01122	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROSU1_01123	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynPROSU1_01126	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynPROSU1_01131	COG1611	Belongs to the LOG family
SynPROSU1_01132	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SynPROSU1_01138	COG0251	oxidation-reduction process
SynPROSU1_01139	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynPROSU1_01140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynPROSU1_01141	COG1132	(ABC) transporter
SynPROSU1_01142	COG0456	acetyltransferase
SynPROSU1_01145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynPROSU1_01146	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynPROSU1_01151	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynPROSU1_01153	COG1845	cytochrome c oxidase, subunit III
SynPROSU1_01154	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynPROSU1_01159	COG0659	secondary active sulfate transmembrane transporter activity
SynPROSU1_01160	COG0418	dihydroorotase activity
SynPROSU1_01165	COG0159	tryptophan synthase activity
SynPROSU1_01168	COG2010	Cytochrome c
SynPROSU1_01177	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROSU1_01181	COG0140	phosphoribosyl-ATP diphosphatase activity
SynPROSU1_01181	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynPROSU1_01183	COG0542	response to heat
SynPROSU1_01194	COG3794	PFAM blue (type 1) copper domain protein
SynPROSU1_01196	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynPROSU1_01197	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynPROSU1_01205	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynPROSU1_01208	COG0339	signal peptide processing
SynPROSU1_01209	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_01210	COG0083	homoserine kinase activity
SynPROSU1_01211	COG0837	glucose binding
SynPROSU1_01213	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynPROSU1_01216	COG0180	Tryptophanyl-tRNA synthetase
SynPROSU1_01235	COG0730	response to heat
SynPROSU1_01247	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynPROSU1_01266	COG1116	anion transmembrane transporter activity
SynPROSU1_01267	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynPROSU1_01270	COG0375	protein maturation
SynPROSU1_01271	COG0010	Belongs to the arginase family
SynPROSU1_01282	COG0484	heat shock protein binding
SynPROSU1_01303	COG3239	Fatty acid desaturase
SynPROSU1_01306	COG0583	DNA-binding transcription factor activity
SynPROSU1_01316	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynPROSU1_01317	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynPROSU1_01318	COG0798	PFAM Bile acid sodium symporter
SynPROSU1_01322	COG0681	Belongs to the peptidase S26 family
SynPROSU1_01323	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynPROSU1_01324	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynPROSU1_01325	COG1376	ErfK ybiS ycfS ynhG family protein
SynPROSU1_01326	COG0297	glycogen (starch) synthase activity
SynPROSU1_01328	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynPROSU1_01329	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynPROSU1_01331	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynPROSU1_01332	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynPROSU1_01333	COG2045	Belongs to the ComB family
SynPROSU1_01336	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynPROSU1_01337	COG0142	geranyltranstransferase activity
SynPROSU1_01338	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynPROSU1_01339	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynPROSU1_01341	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynPROSU1_01342	COG2176	DNA-directed DNA polymerase activity
SynPROSU1_01346	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROSU1_01363	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynPROSU1_01366	COG1132	(ABC) transporter
SynPROSU1_01367	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynPROSU1_01368	COG0505	Belongs to the CarA family
SynPROSU1_01370	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynPROSU1_01371	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynPROSU1_01373	COG0154	amidase activity
SynPROSU1_01375	COG0587	DNA-directed DNA polymerase activity
SynPROSU1_01377	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynPROSU1_01378	COG0632	four-way junction helicase activity
SynPROSU1_01381	COG0358	DNA primase activity
SynPROSU1_01386	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynPROSU1_01390	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynPROSU1_01393	COG0792	nuclease activity
SynPROSU1_01394	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynPROSU1_01395	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynPROSU1_01398	COG0022	dehydrogenase e1 component
SynPROSU1_01398	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynPROSU1_01399	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynPROSU1_01400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynPROSU1_01407	COG0628	permease
SynPROSU1_01409	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynPROSU1_01410	COG0515	serine threonine protein kinase
SynPROSU1_01416	COG2226	methyltransferase
SynPROSU1_01417	COG0174	glutamine synthetase
SynPROSU1_01420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynPROSU1_01424	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynPROSU1_01428	COG0612	Peptidase, M16
SynPROSU1_01434	COG1216	Glycosyl transferase, family 2
SynPROSU1_01435	COG0052	Belongs to the universal ribosomal protein uS2 family
SynPROSU1_01436	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynPROSU1_01438	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynPROSU1_01440	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynPROSU1_01441	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynPROSU1_01442	COG0751	glycine-tRNA ligase activity
SynPROSU1_01444	COG0644	oxidoreductase
SynPROSU1_01447	COG0826	peptidase U32
SynPROSU1_01448	COG1217	gtp-binding protein TYPA
SynPROSU1_01453	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynPROSU1_01464	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynPROSU1_01465	COG1494	fructose-1,6-bisphosphatase
SynPROSU1_01466	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynPROSU1_01467	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROSU1_01468	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynPROSU1_01469	COG0363	glucosamine-6-phosphate deaminase activity
SynPROSU1_01472	COG0129	dihydroxy-acid dehydratase activity
SynPROSU1_01474	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynPROSU1_01475	COG1357	PFAM Pentapeptide repeats (8 copies)
SynPROSU1_01484	COG0300	oxidoreductase activity
SynPROSU1_01499	COG4106	trans-aconitate 2-methyltransferase activity
SynPROSU1_01500	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynPROSU1_01503	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynPROSU1_01504	COG1122	ATPase activity
SynPROSU1_01508	COG1836	PFAM Integral membrane protein DUF92
SynPROSU1_01513	COG3639	organic phosphonate transmembrane transporter activity
SynPROSU1_01514	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynPROSU1_01515	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynPROSU1_01516	COG0436	Aminotransferase
SynPROSU1_01518	COG1573	uracil-dna glycosylase
SynPROSU1_01519	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynPROSU1_01520	COG0793	Belongs to the peptidase S41A family
SynPROSU1_01522	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynPROSU1_01547	COG0861	Integral membrane protein TerC family
SynPROSU1_01550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynPROSU1_01552	COG0312	modulator of DNA gyrase
SynPROSU1_01553	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynPROSU1_01556	COG0163	prenyltransferase activity
SynPROSU1_01557	COG0557	exoribonuclease II activity
SynPROSU1_01560	COG2119	membrane
SynPROSU1_01563	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynPROSU1_01563	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynPROSU1_01564	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynPROSU1_01567	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynPROSU1_01568	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROSU1_01569	COG1615	UPF0182 protein
SynPROSU1_01570	COG0450	alkyl hydroperoxide reductase
SynPROSU1_01573	COG0739	heme binding
SynPROSU1_01574	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynPROSU1_01575	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
SynPROSU1_01580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynPROSU1_01581	COG1233	COG1233 Phytoene dehydrogenase and related
SynPROSU1_01582	COG0557	exoribonuclease II activity
SynPROSU1_01583	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynPROSU1_01584	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynPROSU1_01585	COG0072	phenylalanine-tRNA ligase activity
SynPROSU1_01586	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynPROSU1_01595	COG2385	sporulation resulting in formation of a cellular spore
SynPROSU1_01600	COG0646	methionine synthase
SynPROSU1_01600	COG1410	methionine synthase
SynPROSU1_01601	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynPROSU1_01604	COG0613	PHP domain protein
SynPROSU1_01604	COG0613	PHP domain protein
SynPROSU1_01606	COG1981	membrane
SynPROSU1_01607	COG3046	protein related to deoxyribodipyrimidine photolyase
SynPROSU1_01609	COG0322	excinuclease ABC activity
SynPROSU1_01611	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynPROSU1_01613	COG2027	D-alanyl-D-alanine carboxypeptidase
SynPROSU1_01616	COG1104	cysteine desulfurase activity
SynPROSU1_01617	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynPROSU1_01619	COG0495	leucyl-tRNA aminoacylation
SynPROSU1_01621	COG0166	Belongs to the GPI family
SynPROSU1_01629	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynPROSU1_01630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynPROSU1_01632	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynPROSU1_01632	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynPROSU1_01633	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynPROSU1_01634	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynPROSU1_01635	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynPROSU1_01637	COG0484	heat shock protein binding
SynPROSU1_01638	COG0443	Heat shock 70 kDa protein
SynPROSU1_01639	COG0573	inorganic phosphate transmembrane transporter activity
SynPROSU1_01640	COG0581	inorganic phosphate transmembrane transporter activity
SynPROSU1_01641	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynPROSU1_01644	COG0483	inositol monophosphate 1-phosphatase activity
SynPROSU1_01645	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynPROSU1_01647	COG0326	Molecular chaperone. Has ATPase activity
SynPROSU1_01648	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynPROSU1_01649	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynPROSU1_01650	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynPROSU1_01651	COG1653	transport
SynPROSU1_01652	COG1175	transmembrane transport
SynPROSU1_01660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynPROSU1_01661	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynPROSU1_01663	COG0762	integral membrane protein
SynPROSU1_01666	COG0469	pyruvate kinase activity
SynPROSU1_01667	COG0577	efflux transmembrane transporter activity
SynPROSU1_01667	COG1136	(ABC) transporter
SynPROSU1_01668	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynPROSU1_01669	COG0740	serine-type endopeptidase activity
SynPROSU1_01676	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynPROSU1_01687	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynPROSU1_01688	COG1175	transmembrane transport
SynPROSU1_01689	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynPROSU1_01695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SynPROSU1_01708	COG1793	dna ligase
SynPROSU1_01710	COG1201	RNA secondary structure unwinding
SynPROSU1_01733	COG2226	methyltransferase
SynPROSU1_01740	COG1119	ATPase activity
SynPROSU1_01748	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynPROSU1_01753	COG1121	(ABC) transporter
SynPROSU1_01754	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynPROSU1_01755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynPROSU1_01756	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynPROSU1_01764	COG0572	uridine kinase
SynPROSU1_01782	COG2032	superoxide dismutase activity
SynPROSU1_01786	COG0724	RNA recognition motif
SynPROSU1_01789	COG0463	Glycosyl transferase, family 2
SynPROSU1_01816	COG2124	cytochrome p450
SynPROSU1_01844	COG0405	Gamma-glutamyltransferase
SynPROSU1_01888	COG3659	wide pore channel activity
SynPROSU1_01891	COG3128	pkhd-type hydroxylase
SynPROSU1_01892	COG1840	ABC-type Fe3 transport system, periplasmic component
SynPROSU1_01898	COG0492	ferredoxin-NADP+ reductase activity
SynPROSU1_01899	COG0716	FMN binding
SynPROSU1_01905	COG3659	wide pore channel activity
SynPROSU1_01908	COG2010	Cytochrome c
SynPROSU1_01917	COG2207	Transcriptional regulator
SynPROSU1_01920	COG0701	Predicted permease
SynPROSU1_01925	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynPROSU1_01926	COG1121	(ABC) transporter
SynPROSU1_01927	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynPROSU1_01937	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynPROSU1_01941	COG1640	4-alpha-glucanotransferase
SynPROSU1_01942	COG1187	pseudouridine synthase activity
SynPROSU1_01943	COG5002	protein histidine kinase activity
SynPROSU1_01944	COG0745	RESPONSE REGULATOR receiver
SynPROSU1_01948	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynPROSU1_01949	COG1982	Orn Lys Arg decarboxylase major
SynPROSU1_01950	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynPROSU1_01951	COG0575	Belongs to the CDS family
SynPROSU1_01953	COG2267	carboxylic ester hydrolase activity
SynPROSU1_01954	COG0371	Dehydrogenase
SynPROSU1_01955	COG0542	response to heat
SynPROSU1_01957	COG0019	diaminopimelate decarboxylase activity
SynPROSU1_01958	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynPROSU1_01959	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynPROSU1_01960	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynPROSU1_01971	COG1054	Belongs to the UPF0176 family
SynPROSU1_01976	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynPROSU1_01977	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynPROSU1_01981	COG0475	glutathione-regulated potassium exporter activity
SynPROSU1_01981	COG0589	response to stress
SynPROSU1_01982	COG1132	(ABC) transporter
SynPROSU1_01984	COG0724	RNA recognition motif
SynPROSU1_01988	COG0513	Belongs to the DEAD box helicase family
SynPROSU1_01990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynPROSU1_01994	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynPROSU1_01998	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynPROSU1_02001	COG0271	Belongs to the BolA IbaG family
SynPROSU1_02002	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynPROSU1_02004	COG0745	RESPONSE REGULATOR receiver
SynPROSU1_02021	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynPROSU1_02023	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynPROSU1_02063	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROSU1_02146	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynPROSU1_02155	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynPROSU1_02158	COG0735	belongs to the Fur family
SynPROSU1_02171	COG0625	glutathione transferase activity
SynPROSU1_02179	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynPROSU1_02188	COG1126	abc transporter atp-binding protein
SynPROSU1_02189	COG0765	amino acid transport
SynPROSU1_02190	COG4597	amino acid ABC transporter
SynPROSU1_02191	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynPROSU1_02193	COG0659	secondary active sulfate transmembrane transporter activity
SynPROSU1_02203	COG0799	negative regulation of ribosome biogenesis
SynPROSU1_02205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynPROSU1_02207	COG1115	amino acid carrier protein
SynPROSU1_02209	COG1132	(ABC) transporter
SynPROSU1_02211	COG0149	triose-phosphate isomerase activity
SynPROSU1_02212	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynPROSU1_02216	COG1429	ligase activity, forming nitrogen-metal bonds
SynPROSU1_02217	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynPROSU1_02219	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROSU1_02220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynPROSU1_02222	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynPROSU1_02228	COG2205	protein histidine kinase activity
SynPROSU1_02229	COG2326	polyphosphate kinase activity
SynPROSU1_02238	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynPROSU1_02239	COG0640	Transcriptional regulator
SynPROSU1_02241	COG0668	transmembrane transport
SynPROSU1_02244	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynPROSU1_02245	COG0047	phosphoribosylformylglycinamidine synthase activity
SynPROSU1_02246	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynPROSU1_02248	COG0191	fructose-bisphosphate aldolase activity
SynPROSU1_02249	COG3588	fructose-bisphosphate aldolase
SynPROSU1_02250	COG0673	inositol 2-dehydrogenase activity
SynPROSU1_02252	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynPROSU1_02255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynPROSU1_02257	COG3954	Phosphoribulokinase
SynPROSU1_02258	COG0473	3-isopropylmalate dehydrogenase activity
SynPROSU1_02259	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynPROSU1_02260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynPROSU1_02263	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynPROSU1_02266	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynPROSU1_02267	COG2197	response regulator
SynPROSU1_02269	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynPROSU1_02274	COG1376	ErfK ybiS ycfS ynhG family protein
SynPROSU1_02295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynPROSU1_02297	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynPROSU1_02324	COG0308	aminopeptidase N
SynPROSU1_02328	COG2205	protein histidine kinase activity
SynPROSU1_02333	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynPROSU1_02335	COG1797	cobyrinic acid a,c-diamide synthase activity
SynPROSU1_02336	COG1254	Belongs to the acylphosphatase family
SynPROSU1_02340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynPROSU1_02344	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynPROSU1_02345	COG1480	7TM receptor with intracellular HD hydrolase
SynPROSU1_02347	COG0564	pseudouridine synthase activity
SynPROSU1_02349	COG0011	TIGRFAM Protein of
SynPROSU1_02354	COG0395	ABC-type sugar transport system, permease component
SynPROSU1_02355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynPROSU1_02356	COG1543	Belongs to the glycosyl hydrolase 57 family
SynPROSU1_02357	COG0644	oxidoreductase
SynPROSU1_02358	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynPROSU1_02359	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynPROSU1_02360	COG0516	GMP reductase activity
SynPROSU1_02361	COG3118	belongs to the thioredoxin family
SynPROSU1_02362	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynPROSU1_02363	COG0742	ribosomal rna small subunit methyltransferase
SynPROSU1_02364	COG2010	Cytochrome c
SynPROSU1_02365	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SynPROSU1_02368	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynPROSU1_02369	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynPROSU1_02370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynPROSU1_02372	COG2166	iron-sulfur cluster assembly
SynPROSU1_02373	COG0460	homoserine dehydrogenase
SynPROSU1_02375	COG0747	negative chemotaxis
SynPROSU1_02376	COG0601	transmembrane transport
SynPROSU1_02382	COG0012	GTP binding
SynPROSU1_02384	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynPROSU1_02384	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynPROSU1_02386	COG0215	cysteine-tRNA ligase activity
SynPROSU1_02389	COG0733	neurotransmitter:sodium symporter activity
SynPROSU1_02390	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynPROSU1_02391	COG3411	Ferredoxin
SynPROSU1_02401	COG0492	ferredoxin-NADP+ reductase activity
SynPROSU1_02402	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynPROSU1_02404	COG2226	methyltransferase
SynPROSU1_02409	COG2267	carboxylic ester hydrolase activity
SynPROSU1_02410	COG0440	acetolactate synthase activity
SynPROSU1_02411	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynPROSU1_02417	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynPROSU1_02419	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynPROSU1_02420	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynPROSU1_02422	COG1022	Amp-dependent synthetase and ligase
SynPROSU1_02423	COG0321	lipoyl(octanoyl) transferase activity
SynPROSU1_02424	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynPROSU1_02425	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynPROSU1_02426	COG1381	Involved in DNA repair and RecF pathway recombination
SynPROSU1_02428	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_02435	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynPROSU1_02437	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynPROSU1_02438	COG1799	cell septum assembly
SynPROSU1_02439	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynPROSU1_02441	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynPROSU1_02442	COG1160	GTP binding
SynPROSU1_02444	COG1376	ErfK ybiS ycfS ynhG family protein
SynPROSU1_02446	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynPROSU1_02447	COG1216	Glycosyl transferase, family 2
SynPROSU1_02447	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_02451	COG1088	dTDP-glucose 4,6-dehydratase activity
SynPROSU1_02457	COG0114	fumarate hydratase activity
SynPROSU1_02458	COG4581	dead DEAH box helicase
SynPROSU1_02461	COG0385	Bile acid
SynPROSU1_02462	COG0156	8-amino-7-oxononanoate synthase activity
SynPROSU1_02465	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynPROSU1_02468	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynPROSU1_02471	COG0357	Ribosomal RNA small subunit methyltransferase G
SynPROSU1_02479	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynPROSU1_02480	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROSU1_02481	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynPROSU1_02482	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynPROSU1_02483	COG0085	RNA polymerase activity
SynPROSU1_02484	COG0084	hydrolase, TatD family'
SynPROSU1_02485	COG0268	Binds directly to 16S ribosomal RNA
SynPROSU1_02486	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynPROSU1_02487	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynPROSU1_02488	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynPROSU1_02491	COG0641	radical SAM
SynPROSU1_02493	COG2132	Multicopper oxidase
SynPROSU1_02499	COG5002	protein histidine kinase activity
SynPROSU1_02503	COG0779	Required for maturation of 30S ribosomal subunits
SynPROSU1_02504	COG0195	Participates in both transcription termination and antitermination
SynPROSU1_02506	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynPROSU1_02511	COG3781	membrane
SynPROSU1_02513	COG1053	succinate dehydrogenase
SynPROSU1_02519	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynPROSU1_02520	COG0776	regulation of translation
SynPROSU1_02526	COG2211	Major facilitator Superfamily
SynPROSU1_02527	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynPROSU1_02530	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynPROSU1_02535	COG0284	orotidine-5'-phosphate decarboxylase activity
SynPROSU1_02538	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SynPROSU1_02540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynPROSU1_02551	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynPROSU1_02554	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynPROSU1_02555	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynPROSU1_02556	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynPROSU1_02557	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynPROSU1_02558	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynPROSU1_02560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynPROSU1_02562	COG0151	Belongs to the GarS family
SynPROSU1_02563	COG5002	protein histidine kinase activity
SynPROSU1_02564	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynPROSU1_02565	COG4251	negative regulation of phosphorylation
SynPROSU1_02567	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynPROSU1_02568	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynPROSU1_02569	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynPROSU1_02570	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynPROSU1_02571	COG0217	transcriptional regulatory protein
SynPROSU1_02582	COG0363	glucosamine-6-phosphate deaminase activity
SynPROSU1_02583	COG2385	sporulation resulting in formation of a cellular spore
SynPROSU1_02583	COG2247	cell wall binding repeat
SynPROSU1_02584	COG1234	tRNA 3'-trailer cleavage
SynPROSU1_02585	COG2010	Cytochrome c
SynPROSU1_02588	COG2264	protein methyltransferase activity
SynPROSU1_02589	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynPROSU1_02593	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynPROSU1_02600	COG0443	Heat shock 70 kDa protein
SynPROSU1_02603	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynPROSU1_02604	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynPROSU1_02614	COG0459	protein refolding
SynPROSU1_02615	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynPROSU1_02616	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynPROSU1_02617	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynPROSU1_02622	COG0387	Pfam Sodium calcium exchanger
SynPROSU1_02623	COG0006	proline dipeptidase activity
SynPROSU1_02624	COG0457	Tetratricopeptide repeat
SynPROSU1_02625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynPROSU1_02626	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynPROSU1_02627	COG1253	flavin adenine dinucleotide binding
SynPROSU1_02628	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynPROSU1_02629	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynPROSU1_02630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynPROSU1_02630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynPROSU1_02631	COG0686	Belongs to the AlaDH PNT family
SynPROSU1_02632	COG3012	SEC-C Motif Domain Protein
SynPROSU1_02633	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynPROSU1_02635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynPROSU1_02640	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynPROSU1_02641	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynPROSU1_02642	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynPROSU1_02643	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynPROSU1_02644	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynPROSU1_02645	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynPROSU1_02646	COG0356	it plays a direct role in the translocation of protons across the membrane
SynPROSU1_02648	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynPROSU1_02649	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROSU1_02653	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SynPROSU1_02655	COG0772	Belongs to the SEDS family
SynPROSU1_02657	COG1333	cytochrome c biogenesis protein
SynPROSU1_02658	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynPROSU1_02661	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynPROSU1_02664	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynPROSU1_02666	COG3562	capsule polysaccharide
SynPROSU1_02668	COG1083	cytidylyl-transferase
SynPROSU1_02672	COG2089	acid synthase
SynPROSU1_02688	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROSU1_02704	COG0116	Belongs to the methyltransferase superfamily
SynPROSU1_02713	COG1196	nuclear chromosome segregation
SynPROSU1_02715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynPROSU1_02719	COG0439	Biotin carboxylase
SynPROSU1_02722	COG0515	serine threonine protein kinase
SynPROSU1_02725	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynPROSU1_02726	COG4178	(ABC) transporter
SynPROSU1_02727	COG0537	adenosine 5'-monophosphoramidase activity
SynPROSU1_02728	COG0606	chelatase, subunit chli
SynPROSU1_02732	COG0242	peptide deformylase activity
SynPROSU1_02736	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynPROSU1_02737	COG0719	Fe-S assembly protein
SynPROSU1_02738	COG0396	ATPase activity
SynPROSU1_02739	COG0719	Fe-S assembly protein
SynPROSU1_02740	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynPROSU1_02744	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynPROSU1_02749	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynPROSU1_02753	COG0033	Phosphoglucomutase
SynPROSU1_02755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynPROSU1_02756	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynPROSU1_02757	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SynPROSU1_02760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynPROSU1_02761	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynPROSU1_02762	COG0175	sulfate reduction
SynPROSU1_02763	COG1252	NADH dehydrogenase
SynPROSU1_02764	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynPROSU1_02765	COG3273	potassium ion transport
SynPROSU1_02765	COG0471	metal ion transport
SynPROSU1_02766	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynPROSU1_02767	COG0569	domain protein
SynPROSU1_02768	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynPROSU1_02773	COG0488	(ABC) transporter
SynPROSU1_02775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynPROSU1_02778	COG1643	Atp-dependent helicase
SynPROSU1_02781	COG1570	exodeoxyribonuclease VII activity
SynPROSU1_02793	COG0483	inositol monophosphate 1-phosphatase activity
SynPROSU1_02796	COG1968	undecaprenyl-diphosphatase activity
SynPROSU1_02798	COG1555	photosystem II stabilization
SynPROSU1_02799	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynPROSU1_02800	COG4243	Vitamin k epoxide reductase
SynPROSU1_02801	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynPROSU1_02803	COG1032	radical SAM domain protein
SynPROSU1_02809	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynPROSU1_02814	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynPROSU1_02816	COG0463	Glycosyl transferase, family 2
SynPROSU1_02816	COG0457	Tetratricopeptide repeat
SynPROSU1_02817	COG1587	Uroporphyrinogen-III synthase
SynPROSU1_02820	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynPROSU1_02821	COG0316	Belongs to the HesB IscA family
SynPROSU1_02824	COG1090	epimerase
SynPROSU1_02827	COG0484	heat shock protein binding
SynPROSU1_02828	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynPROSU1_02829	COG3659	wide pore channel activity
SynPROSU1_02831	COG3659	wide pore channel activity
SynPROSU1_02834	COG1215	transferase activity, transferring glycosyl groups
SynPROSU1_02841	COG1122	ATPase activity
SynPROSU1_02844	COG0745	RESPONSE REGULATOR receiver
SynPROSU1_02846	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynPROSU1_02847	COG2217	Heavy metal translocating P-type atpase
SynPROSU1_02848	COG3063	Type IV pilus biogenesis stability protein PilW
SynPROSU1_02849	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynPROSU1_02851	COG0416	fatty acid biosynthetic process
SynPROSU1_02852	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynPROSU1_02853	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynPROSU1_02854	COG0318	PFAM AMP-dependent synthetase and ligase
SynPROSU1_02854	COG0204	Acyl-transferase
SynPROSU1_02856	COG1214	PFAM Peptidase M22, glycoprotease
SynPROSU1_02858	COG0617	tRNA 3'-terminal CCA addition
SynPROSU1_02859	COG0724	RNA recognition motif
SynPROSU1_02860	COG1562	ergosterol biosynthetic process
SynPROSU1_02861	COG0493	'glutamate synthase
SynPROSU1_02861	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynPROSU1_02864	COG0583	DNA-binding transcription factor activity
SynPROSU1_02866	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynPROSU1_02867	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_02870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynPROSU1_02872	COG2197	response regulator
SynPROSU1_02874	COG2954	triphosphatase activity
SynPROSU1_02875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynPROSU1_02876	COG0713	ATP synthesis coupled electron transport
SynPROSU1_02878	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynPROSU1_02879	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynPROSU1_02880	COG0372	Belongs to the citrate synthase family
SynPROSU1_02881	COG2062	phosphohistidine phosphatase, SixA
SynPROSU1_02884	COG1420	regulation of RNA biosynthetic process
SynPROSU1_02885	COG0133	tryptophan synthase activity
SynPROSU1_02887	COG0023	Translation Initiation Factor
SynPROSU1_02888	COG0529	Catalyzes the synthesis of activated sulfate
SynPROSU1_02889	COG0628	permease
SynPROSU1_02891	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynPROSU1_02893	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynPROSU1_02894	COG0564	pseudouridine synthase activity
SynPROSU1_02895	COG0745	RESPONSE REGULATOR receiver
SynPROSU1_02898	COG1104	cysteine desulfurase activity
SynPROSU1_02900	COG0275	rRNA processing
SynPROSU1_02901	COG0649	NAD binding
SynPROSU1_02904	COG0824	Thioesterase
SynPROSU1_02907	COG1575	Belongs to the MenA family. Type 1 subfamily
SynPROSU1_02909	COG0189	ligase activity
SynPROSU1_02910	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynPROSU1_02911	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynPROSU1_02913	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynPROSU1_02914	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynPROSU1_02917	COG0252	asparaginase activity
SynPROSU1_02918	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynPROSU1_02919	COG0018	arginyl-trna synthetase
SynPROSU1_02920	COG0157	Belongs to the NadC ModD family
SynPROSU1_02921	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynPROSU1_02923	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynPROSU1_02924	COG4172	Belongs to the ABC transporter superfamily
SynPROSU1_02926	COG0564	pseudouridine synthase activity
SynPROSU1_02927	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SynPROSU1_02928	COG0126	phosphoglycerate kinase activity
SynPROSU1_02932	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynPROSU1_02933	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynPROSU1_02941	COG0167	dihydroorotate dehydrogenase activity
SynPROSU1_02942	COG0328	RNA-DNA hybrid ribonuclease activity
SynPROSU1_02944	COG0222	ribosome binding
SynPROSU1_02945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynPROSU1_02947	COG0081	regulation of translation
SynPROSU1_02948	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynPROSU1_02950	COG0250	Participates in transcription elongation, termination and antitermination
SynPROSU1_02951	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynPROSU1_02952	COG0542	response to heat
SynPROSU1_02953	COG0346	lactoylglutathione lyase activity
SynPROSU1_02954	COG0148	phosphopyruvate hydratase activity
SynPROSU1_02955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynPROSU1_02959	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynPROSU1_02960	COG0237	dephospho-CoA kinase activity
SynPROSU1_02965	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynPROSU1_02967	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynPROSU1_02967	COG2022	thiamine diphosphate biosynthetic process
SynPROSU1_02971	COG0105	UTP biosynthetic process
SynPROSU1_02972	COG1166	arginine decarboxylase activity
SynPROSU1_02979	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynPROSU1_02981	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynPROSU1_02988	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynPROSU1_02988	COG0426	domain, Protein
SynPROSU1_02996	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynPROSU1_02996	COG0426	domain, Protein
SynPROSU1_02997	COG1773	rubredoxin
SynPROSU1_02997	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynPROSU1_02998	COG1733	regulation of RNA biosynthetic process
SynPROSU1_03000	COG1741	Belongs to the pirin family
SynPROSU1_03003	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynPROSU1_03003	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SynPROSU1_03004	COG0509	glycine decarboxylation via glycine cleavage system
SynPROSU1_03005	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynPROSU1_03008	COG5183	chlorophyll binding
SynPROSU1_03008	COG2133	pyrroloquinoline quinone binding
SynPROSU1_03009	COG0359	binds to the 23S rRNA
SynPROSU1_03010	COG1372	Participates in initiation and elongation during chromosome replication
SynPROSU1_03010	COG1372	Participates in initiation and elongation during chromosome replication
SynPROSU1_03010	COG0305	Participates in initiation and elongation during chromosome replication
SynPROSU1_03010	COG0305	Participates in initiation and elongation during chromosome replication
SynPROSU1_03013	COG0445	tRNA wobble uridine modification
SynPROSU1_03020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynPROSU1_03022	COG0398	Pfam SNARE associated Golgi protein
SynPROSU1_03025	COG1131	(ABC) transporter
SynPROSU1_03030	COG0525	valine-tRNA ligase activity
SynPROSU1_03032	COG0525	valine-tRNA ligase activity
SynPROSU1_03034	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SynPROSU1_03034	COG3264	Mechanosensitive ion channel
SynPROSU1_03040	COG4221	oxidoreductase activity
SynPROSU1_03054	COG3956	TIGRFAM MazG family protein
SynPROSU1_03056	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynPROSU1_03057	COG0010	Belongs to the arginase family
SynPROSU1_03061	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynPROSU1_03062	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynPROSU1_03063	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROSU1_03064	COG0783	Belongs to the Dps family
SynPROSU1_03065	COG0504	CTP synthase activity
SynPROSU1_03066	COG0602	queuosine metabolic process
SynPROSU1_03069	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynPROSU1_03073	COG0366	Alpha amylase catalytic
SynPROSU1_03074	COG0463	Glycosyl transferase, family 2
SynPROSU1_03080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynPROSU1_03088	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynPROSU1_03089	COG0830	nickel cation binding
SynPROSU1_03090	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynPROSU1_03091	COG0829	nickel cation binding
SynPROSU1_03092	COG0831	urea catabolic process
SynPROSU1_03093	COG0832	Belongs to the urease beta subunit family
SynPROSU1_03094	COG0804	urea catabolic process
SynPROSU1_03100	COG0367	asparagine synthase
SynPROSU1_03105	COG2308	Evidence 4 Homologs of previously reported genes of
SynPROSU1_03109	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynPROSU1_03110	COG0746	molybdenum cofactor guanylyltransferase activity
SynPROSU1_03112	COG2223	nitrite transmembrane transporter activity
SynPROSU1_03113	COG0243	molybdopterin cofactor binding
SynPROSU1_03117	COG0315	cyclic pyranopterin monophosphate synthase activity
SynPROSU1_03120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynPROSU1_03121	COG0314	molybdopterin synthase activity
SynPROSU1_03123	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynPROSU1_03124	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynPROSU1_03127	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynPROSU1_03129	COG2116	formate transmembrane transporter activity
SynPROSU1_03131	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynPROSU1_03134	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynPROSU1_03137	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynPROSU1_03138	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynPROSU1_03139	COG0170	dolichyl monophosphate biosynthetic process
SynPROSU1_03140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynPROSU1_03141	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynPROSU1_03143	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynPROSU1_03145	COG0788	formyltetrahydrofolate deformylase activity
SynPROSU1_03148	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynPROSU1_03149	COG0443	Heat shock 70 kDa protein
SynPROSU1_03150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynPROSU1_03152	COG0360	Binds together with S18 to 16S ribosomal RNA
SynPROSU1_03154	COG0137	argininosuccinate synthase activity
SynPROSU1_03157	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynPROSU1_03164	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynPROSU1_03166	COG0438	transferase activity, transferring glycosyl groups
SynPROSU1_03169	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynPROSU1_03170	COG0497	DNA recombination
SynPROSU1_03171	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynPROSU1_03173	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine