locus-tag	class	description
SynROS8604_00001	COG0592	DNA-directed DNA polymerase activity
SynROS8604_00003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynROS8604_00004	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynROS8604_00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynROS8604_00007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynROS8604_00010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynROS8604_00011	COG0552	protein localization to endoplasmic reticulum
SynROS8604_00012	COG2208	phosphoserine phosphatase activity
SynROS8604_00013	COG0165	Argininosuccinate lyase
SynROS8604_00014	COG0724	RNA recognition motif
SynROS8604_00015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynROS8604_00016	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynROS8604_00017	COG2081	HI0933 family
SynROS8604_00018	COG1459	type II secretion system
SynROS8604_00020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynROS8604_00021	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynROS8604_00022	COG0484	heat shock protein binding
SynROS8604_00024	COG1162	GTPase activity
SynROS8604_00025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynROS8604_00026	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynROS8604_00027	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynROS8604_00030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynROS8604_00031	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynROS8604_00032	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynROS8604_00033	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynROS8604_00034	COG0511	ligase activity, forming carbon-carbon bonds
SynROS8604_00035	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynROS8604_00049	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynROS8604_00050	COG0519	Catalyzes the synthesis of GMP from XMP
SynROS8604_00050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynROS8604_00053	COG0768	penicillin binding
SynROS8604_00054	COG0438	transferase activity, transferring glycosyl groups
SynROS8604_00054	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynROS8604_00055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynROS8604_00057	COG2022	thiamine diphosphate biosynthetic process
SynROS8604_00060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynROS8604_00061	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynROS8604_00062	COG2385	sporulation resulting in formation of a cellular spore
SynROS8604_00063	COG1215	transferase activity, transferring glycosyl groups
SynROS8604_00064	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynROS8604_00066	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynROS8604_00067	COG0740	serine-type endopeptidase activity
SynROS8604_00068	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynROS8604_00070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynROS8604_00071	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynROS8604_00072	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynROS8604_00074	COG0037	tRNA processing
SynROS8604_00077	COG0556	nucleotide-excision repair
SynROS8604_00080	COG2082	Precorrin-8x methylmutase
SynROS8604_00081	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynROS8604_00083	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynROS8604_00090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynROS8604_00091	COG1088	dTDP-glucose 4,6-dehydratase activity
SynROS8604_00094	COG1215	transferase activity, transferring glycosyl groups
SynROS8604_00095	COG0438	transferase activity, transferring glycosyl groups
SynROS8604_00107	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynROS8604_00108	COG2274	protein secretion by the type I secretion system
SynROS8604_00110	COG0653	protein targeting
SynROS8604_00112	COG1045	serine acetyltransferase
SynROS8604_00113	COG1725	Transcriptional regulator
SynROS8604_00115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynROS8604_00116	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynROS8604_00117	COG0187	DNA topoisomerase II activity
SynROS8604_00117	COG1372	Participates in initiation and elongation during chromosome replication
SynROS8604_00119	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynROS8604_00120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynROS8604_00121	COG0386	Belongs to the glutathione peroxidase family
SynROS8604_00122	COG2239	Acts as a magnesium transporter
SynROS8604_00123	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynROS8604_00126	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynROS8604_00136	COG1819	glycosyl
SynROS8604_00143	COG2015	COG2015, Alkyl sulfatase and related hydrolases
SynROS8604_00145	COG1194	a g-specific adenine glycosylase
SynROS8604_00147	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynROS8604_00148	COG0242	peptide deformylase activity
SynROS8604_00149	COG2308	Evidence 4 Homologs of previously reported genes of
SynROS8604_00151	COG0189	ligase activity
SynROS8604_00152	COG0697	spore germination
SynROS8604_00158	COG0174	glutamine synthetase
SynROS8604_00161	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SynROS8604_00162	COG0802	atpase or kinase
SynROS8604_00163	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynROS8604_00166	COG0586	Pfam SNARE associated Golgi protein
SynROS8604_00167	COG0629	single-stranded DNA binding
SynROS8604_00173	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynROS8604_00177	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynROS8604_00178	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynROS8604_00179	COG1357	PFAM Pentapeptide repeats (8 copies)
SynROS8604_00179	COG0515	serine threonine protein kinase
SynROS8604_00180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynROS8604_00182	COG2255	four-way junction helicase activity
SynROS8604_00184	COG1473	amidohydrolase
SynROS8604_00187	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynROS8604_00193	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynROS8604_00194	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynROS8604_00195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynROS8604_00196	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynROS8604_00197	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynROS8604_00205	COG2274	protein secretion by the type I secretion system
SynROS8604_00217	COG1215	transferase activity, transferring glycosyl groups
SynROS8604_00230	COG0067	glutamate synthase
SynROS8604_00230	COG0069	glutamate synthase activity
SynROS8604_00230	COG0070	glutamate synthase
SynROS8604_00231	COG0067	glutamate synthase
SynROS8604_00231	COG0069	glutamate synthase activity
SynROS8604_00231	COG0070	glutamate synthase
SynROS8604_00260	COG0297	glycogen (starch) synthase activity
SynROS8604_00263	COG0489	protein tyrosine kinase activity
SynROS8604_00272	COG0297	glycogen (starch) synthase activity
SynROS8604_00275	COG0367	asparagine synthase
SynROS8604_00280	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynROS8604_00281	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynROS8604_00284	COG1132	(ABC) transporter
SynROS8604_00287	COG0438	transferase activity, transferring glycosyl groups
SynROS8604_00290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynROS8604_00293	COG0297	glycogen (starch) synthase activity
SynROS8604_00295	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynROS8604_00298	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynROS8604_00299	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynROS8604_00301	COG0110	maltose O-acetyltransferase activity
SynROS8604_00303	COG0297	glycogen (starch) synthase activity
SynROS8604_00307	COG0494	nUDIX hydrolase
SynROS8604_00323	COG1487	ribonuclease activity
SynROS8604_00325	COG4118	positive regulation of growth
SynROS8604_00334	COG0471	metal ion transport
SynROS8604_00334	COG3273	potassium ion transport
SynROS8604_00335	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynROS8604_00337	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynROS8604_00340	COG0571	ribonuclease III activity
SynROS8604_00348	COG0058	SHG alpha-glucan phosphorylase activity
SynROS8604_00350	COG0475	glutathione-regulated potassium exporter activity
SynROS8604_00354	COG0277	FAD linked oxidase domain protein
SynROS8604_00356	COG0247	lactate metabolic process
SynROS8604_00357	COG0538	isocitrate dehydrogenase activity
SynROS8604_00358	COG0463	Glycosyl transferase, family 2
SynROS8604_00361	COG5398	heme oxygenase
SynROS8604_00363	COG1132	(ABC) transporter
SynROS8604_00364	COG0438	transferase activity, transferring glycosyl groups
SynROS8604_00365	COG0438	transferase activity, transferring glycosyl groups
SynROS8604_00366	COG0438	transferase activity, transferring glycosyl groups
SynROS8604_00367	COG0438	transferase activity, transferring glycosyl groups
SynROS8604_00372	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynROS8604_00374	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynROS8604_00376	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynROS8604_00382	COG0617	tRNA 3'-terminal CCA addition
SynROS8604_00384	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynROS8604_00385	COG0124	histidyl-tRNA synthetase
SynROS8604_00386	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynROS8604_00395	COG4447	cellulose binding
SynROS8604_00396	COG1773	rubredoxin
SynROS8604_00397	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynROS8604_00398	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynROS8604_00399	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynROS8604_00400	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynROS8604_00401	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SynROS8604_00402	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SynROS8604_00403	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynROS8604_00403	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynROS8604_00404	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SynROS8604_00406	COG3039	Transposase
SynROS8604_00414	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SynROS8604_00417	COG1132	(ABC) transporter
SynROS8604_00435	COG0494	nUDIX hydrolase
SynROS8604_00436	COG0415	Belongs to the DNA photolyase family
SynROS8604_00442	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynROS8604_00443	COG3781	membrane
SynROS8604_00444	COG0131	Imidazoleglycerol-phosphate dehydratase
SynROS8604_00445	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynROS8604_00450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynROS8604_00454	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynROS8604_00455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynROS8604_00457	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynROS8604_00458	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynROS8604_00461	COG1253	flavin adenine dinucleotide binding
SynROS8604_00462	COG0673	inositol 2-dehydrogenase activity
SynROS8604_00474	COG0343	queuine tRNA-ribosyltransferase activity
SynROS8604_00480	COG0138	bifunctional purine biosynthesis protein purh
SynROS8604_00484	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynROS8604_00485	COG0004	ammonium transporteR
SynROS8604_00486	COG1489	DNA binding
SynROS8604_00487	COG0728	peptidoglycan biosynthetic process
SynROS8604_00492	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynROS8604_00493	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynROS8604_00494	COG1546	Belongs to the CinA family
SynROS8604_00494	COG1058	Belongs to the CinA family
SynROS8604_00495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynROS8604_00496	COG0066	3-isopropylmalate dehydratase activity
SynROS8604_00503	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynROS8604_00504	COG0193	aminoacyl-tRNA hydrolase activity
SynROS8604_00507	COG4372	Transposase
SynROS8604_00508	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynROS8604_00509	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynROS8604_00511	COG0717	Belongs to the dCTP deaminase family
SynROS8604_00513	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynROS8604_00517	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynROS8604_00520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynROS8604_00525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynROS8604_00529	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynROS8604_00532	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynROS8604_00535	COG2094	Belongs to the DNA glycosylase MPG family
SynROS8604_00536	COG0540	Belongs to the ATCase OTCase family
SynROS8604_00546	COG3536	Protein conserved in bacteria
SynROS8604_00547	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynROS8604_00549	COG0529	Catalyzes the synthesis of activated sulfate
SynROS8604_00549	COG2046	Belongs to the sulfate adenylyltransferase family
SynROS8604_00550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynROS8604_00553	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynROS8604_00555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynROS8604_00556	COG2226	methyltransferase
SynROS8604_00559	COG4176	ABC-type proline glycine betaine transport system permease component
SynROS8604_00560	COG2113	Glycine betaine
SynROS8604_00561	COG0463	Glycosyl transferase, family 2
SynROS8604_00562	COG0366	Alpha amylase catalytic
SynROS8604_00576	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynROS8604_00578	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynROS8604_00579	COG0436	Aminotransferase
SynROS8604_00581	COG1530	ribonuclease E activity
SynROS8604_00582	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynROS8604_00584	COG1605	Chorismate mutase
SynROS8604_00584	COG0077	Prephenate dehydratase
SynROS8604_00585	COG2226	methyltransferase
SynROS8604_00586	COG0051	transcription antitermination factor activity, RNA binding
SynROS8604_00587	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynROS8604_00588	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynROS8604_00589	COG0049	tRNA binding
SynROS8604_00590	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynROS8604_00593	COG0067	glutamate synthase
SynROS8604_00593	COG0069	glutamate synthase activity
SynROS8604_00593	COG0070	glutamate synthase
SynROS8604_00595	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynROS8604_00599	COG2885	chlorophyll binding
SynROS8604_00600	COG2885	chlorophyll binding
SynROS8604_00602	COG3239	Fatty acid desaturase
SynROS8604_00607	COG0463	Glycosyl transferase, family 2
SynROS8604_00612	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynROS8604_00614	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynROS8604_00615	COG0254	rRNA binding
SynROS8604_00616	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynROS8604_00617	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynROS8604_00618	COG0101	tRNA pseudouridine synthase activity
SynROS8604_00619	COG0203	ribosomal protein L17
SynROS8604_00620	COG0202	RNA polymerase activity
SynROS8604_00621	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynROS8604_00622	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynROS8604_00623	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynROS8604_00624	COG0563	adenylate kinase activity
SynROS8604_00625	COG0201	protein transport
SynROS8604_00626	COG0200	Binds to the 23S rRNA
SynROS8604_00627	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynROS8604_00628	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynROS8604_00629	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynROS8604_00630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynROS8604_00631	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynROS8604_00632	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynROS8604_00633	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynROS8604_00634	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynROS8604_00635	COG0255	Belongs to the universal ribosomal protein uL29 family
SynROS8604_00636	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynROS8604_00637	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynROS8604_00638	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynROS8604_00639	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynROS8604_00640	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynROS8604_00641	COG0089	rRNA binding
SynROS8604_00642	COG0088	Forms part of the polypeptide exit tunnel
SynROS8604_00643	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynROS8604_00647	COG3854	ATPases associated with a variety of cellular activities
SynROS8604_00650	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynROS8604_00655	COG0287	Prephenate dehydrogenase
SynROS8604_00657	COG3001	Fructosamine kinase
SynROS8604_00661	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynROS8604_00662	COG1606	tRNA processing
SynROS8604_00663	COG0076	glutamate decarboxylase activity
SynROS8604_00664	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynROS8604_00665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynROS8604_00668	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynROS8604_00670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynROS8604_00672	COG5002	protein histidine kinase activity
SynROS8604_00673	COG0772	Belongs to the SEDS family
SynROS8604_00674	COG0489	protein tyrosine kinase activity
SynROS8604_00675	COG0408	coproporphyrinogen oxidase activity
SynROS8604_00699	COG0667	Aldo Keto reductase
SynROS8604_00701	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynROS8604_00703	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynROS8604_00704	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynROS8604_00704	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynROS8604_00705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynROS8604_00735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynROS8604_00752	COG1070	Carbohydrate kinase
SynROS8604_00753	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynROS8604_00755	COG0539	negative regulation of cytoplasmic translation
SynROS8604_00756	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynROS8604_00762	COG0589	response to stress
SynROS8604_00766	COG0758	DNA mediated transformation
SynROS8604_00767	COG2890	protein-(glutamine-N5) methyltransferase activity
SynROS8604_00768	COG0009	L-threonylcarbamoyladenylate synthase
SynROS8604_00772	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynROS8604_00773	COG2894	cell division
SynROS8604_00774	COG0850	regulation of cytokinetic process
SynROS8604_00775	COG1078	dGTPase activity
SynROS8604_00776	COG0793	Belongs to the peptidase S41A family
SynROS8604_00777	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynROS8604_00778	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynROS8604_00786	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynROS8604_00789	COG0514	ATP-dependent DNA helicase (RecQ)
SynROS8604_00790	COG1388	LysM domain
SynROS8604_00790	COG3942	CHAP domain
SynROS8604_00791	COG1012	belongs to the aldehyde dehydrogenase family
SynROS8604_00793	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynROS8604_00800	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynROS8604_00809	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynROS8604_00817	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynROS8604_00819	COG1376	ErfK ybiS ycfS ynhG family protein
SynROS8604_00820	COG1160	GTP binding
SynROS8604_00821	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynROS8604_00823	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynROS8604_00824	COG1799	cell septum assembly
SynROS8604_00825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynROS8604_00826	COG0438	transferase activity, transferring glycosyl groups
SynROS8604_00828	COG1381	Involved in DNA repair and RecF pathway recombination
SynROS8604_00829	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynROS8604_00830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynROS8604_00831	COG0321	lipoyl(octanoyl) transferase activity
SynROS8604_00832	COG1022	Amp-dependent synthetase and ligase
SynROS8604_00834	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynROS8604_00835	COG0531	amino acid
SynROS8604_00836	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynROS8604_00855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynROS8604_00861	COG0626	cystathionine gamma-synthase activity
SynROS8604_00864	COG4178	(ABC) transporter
SynROS8604_00870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynROS8604_00873	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynROS8604_00875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynROS8604_00879	COG1104	cysteine desulfurase activity
SynROS8604_00884	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynROS8604_00885	COG0579	oxidoreductase
SynROS8604_00887	COG0481	GTPase activity
SynROS8604_00898	COG0745	RESPONSE REGULATOR receiver
SynROS8604_00905	COG5002	protein histidine kinase activity
SynROS8604_00908	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynROS8604_00912	COG3695	enzyme binding
SynROS8604_00913	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynROS8604_00913	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynROS8604_00914	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynROS8604_00915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynROS8604_00917	COG0107	imidazoleglycerol-phosphate synthase activity
SynROS8604_00919	COG2226	methyltransferase
SynROS8604_00924	COG0752	glycyl-tRNA synthetase alpha subunit
SynROS8604_00948	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynROS8604_00949	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynROS8604_00951	COG0740	serine-type endopeptidase activity
SynROS8604_00952	COG0740	serine-type endopeptidase activity
SynROS8604_00953	COG4956	integral membrane protein (PIN domain superfamily)
SynROS8604_00954	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynROS8604_00955	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynROS8604_00956	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynROS8604_00959	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynROS8604_00960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynROS8604_00961	COG4948	Mandelate Racemase Muconate Lactonizing
SynROS8604_00968	COG1357	PFAM Pentapeptide repeats (8 copies)
SynROS8604_00969	COG0285	dihydrofolate synthase activity
SynROS8604_00970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynROS8604_00972	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynROS8604_00975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynROS8604_00976	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynROS8604_00977	COG0134	indole-3-glycerol-phosphate synthase activity
SynROS8604_00983	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynROS8604_00984	COG0482	sulfurtransferase activity
SynROS8604_00985	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynROS8604_00985	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynROS8604_00987	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynROS8604_01006	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynROS8604_01007	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynROS8604_01010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynROS8604_01011	COG0228	four-way junction DNA binding
SynROS8604_01012	COG1702	phosphate starvation-inducible protein PhoH
SynROS8604_01019	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynROS8604_01021	COG0336	Belongs to the RNA methyltransferase TrmD family
SynROS8604_01033	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynROS8604_01034	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynROS8604_01039	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SynROS8604_01041	COG1691	(AIR) carboxylase
SynROS8604_01045	COG0352	thiamine-phosphate diphosphorylase activity
SynROS8604_01047	COG0196	riboflavin kinase activity
SynROS8604_01052	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynROS8604_01053	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynROS8604_01059	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynROS8604_01061	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynROS8604_01090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynROS8604_01094	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SynROS8604_01097	COG1715	Restriction endonuclease
SynROS8604_01115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynROS8604_01117	COG1803	Methylglyoxal synthase
SynROS8604_01117	COG1597	lipid kinase activity
SynROS8604_01125	COG3119	arylsulfatase activity
SynROS8604_01156	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynROS8604_01156	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynROS8604_01157	COG0656	L-ascorbic acid biosynthetic process
SynROS8604_01159	COG1803	Methylglyoxal synthase
SynROS8604_01160	COG0656	L-ascorbic acid biosynthetic process
SynROS8604_01163	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynROS8604_01166	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynROS8604_01171	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynROS8604_01207	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynROS8604_01216	COG1942	4-Oxalocrotonate Tautomerase
SynROS8604_01232	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynROS8604_01239	COG0477	Major facilitator Superfamily
SynROS8604_01243	COG0432	Pfam Uncharacterised protein family UPF0047
SynROS8604_01248	COG1492	cobalamin metabolic process
SynROS8604_01253	COG0424	maF-like protein
SynROS8604_01258	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynROS8604_01259	COG0440	acetolactate synthase activity
SynROS8604_01260	COG2267	carboxylic ester hydrolase activity
SynROS8604_01269	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynROS8604_01270	COG0492	ferredoxin-NADP+ reductase activity
SynROS8604_01280	COG3411	Ferredoxin
SynROS8604_01281	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynROS8604_01282	COG0733	neurotransmitter:sodium symporter activity
SynROS8604_01286	COG0215	cysteine-tRNA ligase activity
SynROS8604_01289	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynROS8604_01289	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynROS8604_01290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynROS8604_01291	COG0012	GTP binding
SynROS8604_01301	COG0601	transmembrane transport
SynROS8604_01302	COG4166	transmembrane transport
SynROS8604_01304	COG0460	homoserine dehydrogenase
SynROS8604_01305	COG2166	iron-sulfur cluster assembly
SynROS8604_01307	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynROS8604_01310	COG0288	reversible hydration of carbon dioxide
SynROS8604_01330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynROS8604_01331	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynROS8604_01334	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SynROS8604_01335	COG2010	Cytochrome c
SynROS8604_01337	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynROS8604_01338	COG3118	belongs to the thioredoxin family
SynROS8604_01339	COG0516	GMP reductase activity
SynROS8604_01342	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynROS8604_01343	COG0644	oxidoreductase
SynROS8604_01344	COG1543	Belongs to the glycosyl hydrolase 57 family
SynROS8604_01345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynROS8604_01346	COG0395	ABC-type sugar transport system, permease component
SynROS8604_01349	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynROS8604_01359	COG1480	7TM receptor with intracellular HD hydrolase
SynROS8604_01360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynROS8604_01361	COG0142	geranyltranstransferase activity
SynROS8604_01374	COG0406	alpha-ribazole phosphatase activity
SynROS8604_01375	COG1254	Belongs to the acylphosphatase family
SynROS8604_01376	COG1797	cobyrinic acid a,c-diamide synthase activity
SynROS8604_01377	COG3409	Peptidoglycan-binding domain 1 protein
SynROS8604_01377	COG3429	Glucose-6-phosphate dehydrogenase subunit
SynROS8604_01378	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynROS8604_01384	COG2205	protein histidine kinase activity
SynROS8604_01387	COG0308	aminopeptidase N
SynROS8604_01389	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynROS8604_01393	COG1640	4-alpha-glucanotransferase
SynROS8604_01395	COG1187	pseudouridine synthase activity
SynROS8604_01396	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynROS8604_01398	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynROS8604_01400	COG1982	Orn Lys Arg decarboxylase major
SynROS8604_01401	COG0575	Belongs to the CDS family
SynROS8604_01403	COG2267	carboxylic ester hydrolase activity
SynROS8604_01404	COG0371	Dehydrogenase
SynROS8604_01405	COG0542	response to heat
SynROS8604_01406	COG0456	acetyltransferase
SynROS8604_01407	COG0019	diaminopimelate decarboxylase activity
SynROS8604_01408	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynROS8604_01409	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynROS8604_01410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynROS8604_01411	COG1054	Belongs to the UPF0176 family
SynROS8604_01414	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynROS8604_01415	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynROS8604_01430	COG0589	response to stress
SynROS8604_01430	COG0475	glutathione-regulated potassium exporter activity
SynROS8604_01431	COG1132	(ABC) transporter
SynROS8604_01433	COG0724	RNA recognition motif
SynROS8604_01436	COG0513	Belongs to the DEAD box helicase family
SynROS8604_01437	COG0662	Cupin 2, conserved barrel domain protein
SynROS8604_01437	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynROS8604_01438	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynROS8604_01439	COG1074	ATP-dependent DNA helicase activity
SynROS8604_01440	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynROS8604_01450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynROS8604_01473	COG2205	protein histidine kinase activity
SynROS8604_01474	COG0745	RESPONSE REGULATOR receiver
SynROS8604_01476	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynROS8604_01478	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynROS8604_01484	COG0745	RESPONSE REGULATOR receiver
SynROS8604_01486	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynROS8604_01487	COG0271	Belongs to the BolA IbaG family
SynROS8604_01490	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynROS8604_01498	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SynROS8604_01501	COG0625	glutathione transferase activity
SynROS8604_01507	COG0735	belongs to the Fur family
SynROS8604_01509	COG1799	cell septum assembly
SynROS8604_01512	COG0625	glutathione transferase activity
SynROS8604_01517	COG0420	3'-5' exonuclease activity
SynROS8604_01523	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynROS8604_01527	COG1126	abc transporter atp-binding protein
SynROS8604_01528	COG0765	amino acid transport
SynROS8604_01530	COG4597	amino acid ABC transporter
SynROS8604_01531	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynROS8604_01533	COG0659	secondary active sulfate transmembrane transporter activity
SynROS8604_01545	COG0799	negative regulation of ribosome biogenesis
SynROS8604_01548	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynROS8604_01550	COG1115	amino acid carrier protein
SynROS8604_01553	COG1132	(ABC) transporter
SynROS8604_01556	COG0149	triose-phosphate isomerase activity
SynROS8604_01557	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynROS8604_01559	COG1429	ligase activity, forming nitrogen-metal bonds
SynROS8604_01560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynROS8604_01562	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynROS8604_01563	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynROS8604_01565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynROS8604_01595	COG0393	Putative heavy-metal-binding
SynROS8604_01610	COG0668	transmembrane transport
SynROS8604_01611	COG4106	trans-aconitate 2-methyltransferase activity
SynROS8604_01612	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynROS8604_01615	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynROS8604_01616	COG1122	ATPase activity
SynROS8604_01618	COG0052	Belongs to the universal ribosomal protein uS2 family
SynROS8604_01619	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynROS8604_01621	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynROS8604_01622	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynROS8604_01623	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynROS8604_01624	COG0751	glycine-tRNA ligase activity
SynROS8604_01625	COG0644	oxidoreductase
SynROS8604_01627	COG0826	peptidase U32
SynROS8604_01628	COG1217	gtp-binding protein TYPA
SynROS8604_01633	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynROS8604_01641	COG0443	Heat shock 70 kDa protein
SynROS8604_01643	COG0861	Integral membrane protein TerC family
SynROS8604_01648	COG0513	Belongs to the DEAD box helicase family
SynROS8604_01649	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynROS8604_01651	COG0312	modulator of DNA gyrase
SynROS8604_01652	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynROS8604_01655	COG0163	prenyltransferase activity
SynROS8604_01656	COG0557	exoribonuclease II activity
SynROS8604_01658	COG2119	membrane
SynROS8604_01663	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynROS8604_01663	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynROS8604_01667	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynROS8604_01668	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynROS8604_01669	COG1615	UPF0182 protein
SynROS8604_01672	COG0450	alkyl hydroperoxide reductase
SynROS8604_01675	COG0739	heme binding
SynROS8604_01676	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynROS8604_01698	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynROS8604_01701	COG0557	exoribonuclease II activity
SynROS8604_01702	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynROS8604_01703	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynROS8604_01704	COG0072	phenylalanine-tRNA ligase activity
SynROS8604_01704	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynROS8604_01705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynROS8604_01714	COG2385	sporulation resulting in formation of a cellular spore
SynROS8604_01720	COG0646	methionine synthase
SynROS8604_01720	COG1410	methionine synthase
SynROS8604_01721	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynROS8604_01724	COG0613	PHP domain protein
SynROS8604_01725	COG1981	membrane
SynROS8604_01726	COG3046	protein related to deoxyribodipyrimidine photolyase
SynROS8604_01728	COG0322	excinuclease ABC activity
SynROS8604_01729	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynROS8604_01734	COG1104	cysteine desulfurase activity
SynROS8604_01735	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynROS8604_01737	COG0495	leucyl-tRNA aminoacylation
SynROS8604_01738	COG0166	Belongs to the GPI family
SynROS8604_01743	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynROS8604_01744	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynROS8604_01745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynROS8604_01745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynROS8604_01746	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynROS8604_01747	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynROS8604_01748	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynROS8604_01750	COG0484	heat shock protein binding
SynROS8604_01751	COG0443	Heat shock 70 kDa protein
SynROS8604_01752	COG0573	inorganic phosphate transmembrane transporter activity
SynROS8604_01753	COG0581	inorganic phosphate transmembrane transporter activity
SynROS8604_01754	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynROS8604_01758	COG0483	inositol monophosphate 1-phosphatase activity
SynROS8604_01759	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynROS8604_01762	COG0326	Molecular chaperone. Has ATPase activity
SynROS8604_01763	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynROS8604_01764	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynROS8604_01765	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynROS8604_01766	COG1653	transport
SynROS8604_01774	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynROS8604_01775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynROS8604_01779	COG0469	pyruvate kinase activity
SynROS8604_01780	COG0577	efflux transmembrane transporter activity
SynROS8604_01780	COG1136	(ABC) transporter
SynROS8604_01781	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynROS8604_01782	COG0740	serine-type endopeptidase activity
SynROS8604_01789	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynROS8604_01790	COG2211	Major facilitator Superfamily
SynROS8604_01794	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynROS8604_01795	COG1175	transmembrane transport
SynROS8604_01796	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynROS8604_01806	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SynROS8604_01806	COG1793	dna ligase
SynROS8604_01808	COG1201	RNA secondary structure unwinding
SynROS8604_01818	COG0484	heat shock protein binding
SynROS8604_01822	COG1121	(ABC) transporter
SynROS8604_01823	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynROS8604_01824	COG3659	wide pore channel activity
SynROS8604_01833	COG2124	cytochrome p450
SynROS8604_01834	COG2226	methyltransferase
SynROS8604_01840	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SynROS8604_01842	COG2124	cytochrome p450
SynROS8604_01850	COG2124	cytochrome p450
SynROS8604_01853	COG1454	alcohol dehydrogenase
SynROS8604_01854	COG0405	Gamma-glutamyltransferase
SynROS8604_01871	COG1322	Protein conserved in bacteria
SynROS8604_01896	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SynROS8604_01897	COG1611	Belongs to the LOG family
SynROS8604_01899	COG2197	response regulator
SynROS8604_01918	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SynROS8604_01936	COG2132	Multicopper oxidase
SynROS8604_01940	COG3659	wide pore channel activity
SynROS8604_01942	COG3659	wide pore channel activity
SynROS8604_01957	COG3961	Belongs to the TPP enzyme family
SynROS8604_01958	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SynROS8604_01960	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SynROS8604_01986	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SynROS8604_01997	COG3961	Belongs to the TPP enzyme family
SynROS8604_02010	COG0523	cobalamin synthesis protein
SynROS8604_02037	COG2144	transferase activity, transferring acyl groups
SynROS8604_02047	COG2132	Multicopper oxidase
SynROS8604_02050	COG5002	protein histidine kinase activity
SynROS8604_02059	COG0681	Belongs to the peptidase S26 family
SynROS8604_02060	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynROS8604_02062	COG1376	ErfK ybiS ycfS ynhG family protein
SynROS8604_02063	COG0297	glycogen (starch) synthase activity
SynROS8604_02065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynROS8604_02067	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynROS8604_02072	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SynROS8604_02072	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynROS8604_02073	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynROS8604_02079	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynROS8604_02081	COG3659	wide pore channel activity
SynROS8604_02083	COG3128	pkhd-type hydroxylase
SynROS8604_02085	COG1840	ABC-type Fe3 transport system, periplasmic component
SynROS8604_02086	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynROS8604_02087	COG2045	Belongs to the ComB family
SynROS8604_02089	COG0860	N-Acetylmuramoyl-L-alanine amidase
SynROS8604_02090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynROS8604_02091	COG0142	geranyltranstransferase activity
SynROS8604_02092	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynROS8604_02094	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynROS8604_02097	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynROS8604_02098	COG2176	DNA-directed DNA polymerase activity
SynROS8604_02101	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynROS8604_02103	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynROS8604_02105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynROS8604_02106	COG0745	RESPONSE REGULATOR receiver
SynROS8604_02108	COG3659	wide pore channel activity
SynROS8604_02112	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynROS8604_02113	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SynROS8604_02116	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynROS8604_02119	COG0174	glutamine synthetase
SynROS8604_02129	COG2226	methyltransferase
SynROS8604_02134	COG0515	serine threonine protein kinase
SynROS8604_02135	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynROS8604_02137	COG1012	belongs to the aldehyde dehydrogenase family
SynROS8604_02138	COG0628	permease
SynROS8604_02140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynROS8604_02140	COG0426	domain, Protein
SynROS8604_02142	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynROS8604_02143	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynROS8604_02144	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynROS8604_02144	COG0022	dehydrogenase e1 component
SynROS8604_02147	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynROS8604_02148	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynROS8604_02149	COG0572	uridine kinase
SynROS8604_02154	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynROS8604_02159	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynROS8604_02161	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynROS8604_02168	COG0358	DNA primase activity
SynROS8604_02185	COG0632	four-way junction helicase activity
SynROS8604_02186	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynROS8604_02188	COG0587	DNA-directed DNA polymerase activity
SynROS8604_02189	COG0154	amidase activity
SynROS8604_02191	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynROS8604_02192	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynROS8604_02193	COG1366	Belongs to the anti-sigma-factor antagonist family
SynROS8604_02194	COG0505	Belongs to the CarA family
SynROS8604_02195	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynROS8604_02197	COG1132	(ABC) transporter
SynROS8604_02199	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynROS8604_02218	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynROS8604_02269	COG0612	Peptidase, M16
SynROS8604_02273	COG1136	(ABC) transporter
SynROS8604_02275	COG1216	Glycosyl transferase, family 2
SynROS8604_02279	COG1836	PFAM Integral membrane protein DUF92
SynROS8604_02282	COG3639	organic phosphonate transmembrane transporter activity
SynROS8604_02283	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynROS8604_02283	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynROS8604_02284	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynROS8604_02285	COG0436	Aminotransferase
SynROS8604_02287	COG1573	uracil-dna glycosylase
SynROS8604_02288	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynROS8604_02289	COG0793	Belongs to the peptidase S41A family
SynROS8604_02293	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynROS8604_02300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynROS8604_02301	COG1494	fructose-1,6-bisphosphatase
SynROS8604_02302	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynROS8604_02303	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynROS8604_02304	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynROS8604_02305	COG0363	glucosamine-6-phosphate deaminase activity
SynROS8604_02308	COG0129	dihydroxy-acid dehydratase activity
SynROS8604_02310	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynROS8604_02318	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynROS8604_02319	COG0047	phosphoribosylformylglycinamidine synthase activity
SynROS8604_02320	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynROS8604_02321	COG0191	fructose-bisphosphate aldolase activity
SynROS8604_02325	COG0673	inositol 2-dehydrogenase activity
SynROS8604_02327	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynROS8604_02328	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynROS8604_02331	COG3954	Phosphoribulokinase
SynROS8604_02332	COG0473	3-isopropylmalate dehydrogenase activity
SynROS8604_02333	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynROS8604_02334	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynROS8604_02337	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynROS8604_02340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynROS8604_02341	COG2197	response regulator
SynROS8604_02343	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynROS8604_02346	COG0517	IMP dehydrogenase activity
SynROS8604_02348	COG1376	ErfK ybiS ycfS ynhG family protein
SynROS8604_02359	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynROS8604_02374	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynROS8604_02376	COG1121	(ABC) transporter
SynROS8604_02379	COG0701	Predicted permease
SynROS8604_02380	COG2010	Cytochrome c
SynROS8604_02384	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynROS8604_02385	COG1121	(ABC) transporter
SynROS8604_02400	COG2032	superoxide dismutase activity
SynROS8604_02445	COG0300	oxidoreductase activity
SynROS8604_02451	COG0730	response to heat
SynROS8604_02482	COG1064	alcohol dehydrogenase
SynROS8604_02484	COG1064	alcohol dehydrogenase
SynROS8604_02491	COG3781	membrane
SynROS8604_02501	COG0500	methyltransferase
SynROS8604_02509	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynROS8604_02510	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynROS8604_02514	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SynROS8604_02516	COG0284	orotidine-5'-phosphate decarboxylase activity
SynROS8604_02516	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynROS8604_02524	COG0180	Tryptophanyl-tRNA synthetase
SynROS8604_02527	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynROS8604_02529	COG0837	glucose binding
SynROS8604_02530	COG0083	homoserine kinase activity
SynROS8604_02531	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynROS8604_02532	COG0339	signal peptide processing
SynROS8604_02538	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SynROS8604_02539	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynROS8604_02547	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynROS8604_02548	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynROS8604_02550	COG3794	PFAM blue (type 1) copper domain protein
SynROS8604_02559	COG0542	response to heat
SynROS8604_02561	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynROS8604_02561	COG0140	phosphoribosyl-ATP diphosphatase activity
SynROS8604_02564	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynROS8604_02572	COG0159	tryptophan synthase activity
SynROS8604_02576	COG0418	dihydroorotase activity
SynROS8604_02577	COG0659	secondary active sulfate transmembrane transporter activity
SynROS8604_02582	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynROS8604_02583	COG1845	cytochrome c oxidase, subunit III
SynROS8604_02585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynROS8604_02587	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynROS8604_02588	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynROS8604_02591	COG0456	acetyltransferase
SynROS8604_02593	COG1132	(ABC) transporter
SynROS8604_02594	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynROS8604_02595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynROS8604_02596	COG3842	ATPase activity
SynROS8604_02597	COG0251	oxidation-reduction process
SynROS8604_02605	COG0492	ferredoxin-NADP+ reductase activity
SynROS8604_02608	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynROS8604_02612	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynROS8604_02613	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynROS8604_02614	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynROS8604_02619	COG4451	ribulose bisphosphate carboxylase, small
SynROS8604_02620	COG1850	ribulose-bisphosphate carboxylase activity
SynROS8604_02621	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynROS8604_02623	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynROS8604_02624	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynROS8604_02627	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynROS8604_02628	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynROS8604_02630	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynROS8604_02636	COG0730	response to heat
SynROS8604_02637	COG0095	Lipoate-protein ligase
SynROS8604_02638	COG1994	Peptidase M50
SynROS8604_02638	COG0517	IMP dehydrogenase activity
SynROS8604_02639	COG0135	phosphoribosylanthranilate isomerase activity
SynROS8604_02641	COG0302	gtp cyclohydrolase
SynROS8604_02642	COG1028	Short-chain dehydrogenase reductase Sdr
SynROS8604_02643	COG0825	malonyl-CoA metabolic process
SynROS8604_02644	COG5322	oxidoreductase activity
SynROS8604_02645	COG3396	Phenylacetate-CoA oxygenase
SynROS8604_02647	COG0539	negative regulation of cytoplasmic translation
SynROS8604_02650	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynROS8604_02651	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynROS8604_02655	COG0028	Belongs to the TPP enzyme family
SynROS8604_02656	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynROS8604_02657	COG0582	viral genome integration into host DNA
SynROS8604_02658	COG2226	methyltransferase
SynROS8604_02660	COG0528	UMP kinase activity
SynROS8604_02661	COG0233	cytoplasmic translational termination
SynROS8604_02662	COG0644	oxidoreductase
SynROS8604_02663	COG0415	Belongs to the DNA photolyase family
SynROS8604_02664	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynROS8604_02665	COG0768	penicillin binding
SynROS8604_02669	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SynROS8604_02670	COG0681	Belongs to the peptidase S26 family
SynROS8604_02674	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynROS8604_02677	COG0442	prolyl-tRNA aminoacylation
SynROS8604_02680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynROS8604_02681	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynROS8604_02684	COG0629	single-stranded DNA binding
SynROS8604_02687	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynROS8604_02689	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynROS8604_02691	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynROS8604_02694	COG0181	hydroxymethylbilane synthase activity
SynROS8604_02699	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynROS8604_02700	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynROS8604_02704	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynROS8604_02705	COG0523	cobalamin synthesis protein
SynROS8604_02712	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynROS8604_02718	COG0708	Exodeoxyribonuclease III
SynROS8604_02719	COG0277	FAD linked oxidase domain protein
SynROS8604_02721	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynROS8604_02725	COG1666	GTP binding
SynROS8604_02795	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynROS8604_02796	COG1218	3'(2'),5'-bisphosphate nucleotidase
SynROS8604_02797	COG1185	polyribonucleotide nucleotidyltransferase activity
SynROS8604_02798	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynROS8604_02799	COG0750	zinc metalloprotease
SynROS8604_02800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynROS8604_02802	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynROS8604_02804	COG0706	membrane insertase activity
SynROS8604_02807	COG0594	ribonuclease P activity
SynROS8604_02808	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynROS8604_02811	COG0616	signal peptide processing
SynROS8604_02813	COG0697	spore germination
SynROS8604_02814	COG0438	transferase activity, transferring glycosyl groups
SynROS8604_02817	COG1842	Phage shock protein A
SynROS8604_02818	COG3118	belongs to the thioredoxin family
SynROS8604_02819	COG0436	Aminotransferase
SynROS8604_02820	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynROS8604_02820	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynROS8604_02821	COG0739	heme binding
SynROS8604_02822	COG0745	RESPONSE REGULATOR receiver
SynROS8604_02823	COG0577	efflux transmembrane transporter activity
SynROS8604_02823	COG1136	(ABC) transporter
SynROS8604_02824	COG1007	ATP synthesis coupled electron transport
SynROS8604_02825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynROS8604_02828	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynROS8604_02835	COG1845	cytochrome c oxidase, subunit III
SynROS8604_02836	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynROS8604_02838	COG1612	heme a metabolic process
SynROS8604_02839	COG0109	protoheme IX farnesyltransferase activity
SynROS8604_02843	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynROS8604_02845	COG0459	protein refolding
SynROS8604_02847	COG1028	Short-chain dehydrogenase reductase Sdr
SynROS8604_02848	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynROS8604_02850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynROS8604_02851	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynROS8604_02852	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynROS8604_02853	COG0248	Ppx GppA phosphatase
SynROS8604_02857	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynROS8604_02858	COG0739	heme binding
SynROS8604_02859	COG0723	plastoquinol--plastocyanin reductase activity
SynROS8604_02861	COG0805	protein transport
SynROS8604_02863	COG0194	GDP metabolic process
SynROS8604_02866	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynROS8604_02867	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynROS8604_02869	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynROS8604_02872	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynROS8604_02877	COG0335	large ribosomal subunit rRNA binding
SynROS8604_02879	COG0024	Methionine aminopeptidase
SynROS8604_02880	COG0300	oxidoreductase activity
SynROS8604_02880	COG3000	fatty acid hydroxylase
SynROS8604_02881	COG0857	belongs to the CobB CobQ family
SynROS8604_02899	COG0776	regulation of translation
SynROS8604_02910	COG3551	Protein conserved in bacteria
SynROS8604_02915	COG0604	alcohol dehydrogenase
SynROS8604_02915	COG3321	synthase
SynROS8604_02932	COG0733	neurotransmitter:sodium symporter activity
SynROS8604_02960	COG2211	Major facilitator Superfamily
SynROS8604_02961	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynROS8604_02964	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynROS8604_02972	COG0284	orotidine-5'-phosphate decarboxylase activity
SynROS8604_02973	COG3386	PFAM SMP-30 Gluconolaconase
SynROS8604_02975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynROS8604_02977	COG2197	response regulator
SynROS8604_02980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynROS8604_02983	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynROS8604_02985	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynROS8604_02986	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynROS8604_02987	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynROS8604_02989	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynROS8604_02991	COG0151	Belongs to the GarS family
SynROS8604_02992	COG5002	protein histidine kinase activity
SynROS8604_02993	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynROS8604_02994	COG4251	negative regulation of phosphorylation
SynROS8604_02996	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynROS8604_02997	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynROS8604_03004	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynROS8604_03005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynROS8604_03006	COG0217	transcriptional regulatory protein
SynROS8604_03023	COG1214	PFAM Peptidase M22, glycoprotease
SynROS8604_03023	COG0456	acetyltransferase
SynROS8604_03026	COG2223	nitrite transmembrane transporter activity
SynROS8604_03041	COG0363	glucosamine-6-phosphate deaminase activity
SynROS8604_03042	COG2247	cell wall binding repeat
SynROS8604_03042	COG2385	sporulation resulting in formation of a cellular spore
SynROS8604_03043	COG1234	tRNA 3'-trailer cleavage
SynROS8604_03044	COG2010	Cytochrome c
SynROS8604_03047	COG2264	protein methyltransferase activity
SynROS8604_03048	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynROS8604_03052	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynROS8604_03065	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynROS8604_03073	COG0004	ammonium transporteR
SynROS8604_03074	COG0459	protein refolding
SynROS8604_03075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynROS8604_03076	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynROS8604_03077	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynROS8604_03080	COG0387	Pfam Sodium calcium exchanger
SynROS8604_03081	COG0006	proline dipeptidase activity
SynROS8604_03082	COG1253	flavin adenine dinucleotide binding
SynROS8604_03083	COG1160	GTP binding
SynROS8604_03084	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynROS8604_03085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynROS8604_03085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynROS8604_03086	COG0686	Belongs to the AlaDH PNT family
SynROS8604_03090	COG3012	SEC-C Motif Domain Protein
SynROS8604_03091	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynROS8604_03093	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynROS8604_03095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynROS8604_03096	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynROS8604_03097	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynROS8604_03098	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynROS8604_03099	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynROS8604_03100	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynROS8604_03101	COG0356	it plays a direct role in the translocation of protons across the membrane
SynROS8604_03103	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynROS8604_03104	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynROS8604_03109	COG0772	Belongs to the SEDS family
SynROS8604_03111	COG1333	cytochrome c biogenesis protein
SynROS8604_03112	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynROS8604_03114	COG0347	Belongs to the P(II) protein family
SynROS8604_03115	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SynROS8604_03117	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynROS8604_03118	COG0114	fumarate hydratase activity
SynROS8604_03119	COG4581	dead DEAH box helicase
SynROS8604_03120	COG0156	8-amino-7-oxononanoate synthase activity
SynROS8604_03122	COG2226	methyltransferase
SynROS8604_03123	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynROS8604_03123	COG4106	trans-aconitate 2-methyltransferase activity
SynROS8604_03125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynROS8604_03128	COG0357	Ribosomal RNA small subunit methyltransferase G
SynROS8604_03136	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynROS8604_03138	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynROS8604_03140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynROS8604_03141	COG0085	RNA polymerase activity
SynROS8604_03142	COG0084	hydrolase, TatD family'
SynROS8604_03143	COG0268	Binds directly to 16S ribosomal RNA
SynROS8604_03144	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynROS8604_03145	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynROS8604_03146	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynROS8604_03156	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynROS8604_03156	COG2205	protein histidine kinase activity
SynROS8604_03158	COG0641	radical SAM
SynROS8604_03160	COG0779	Required for maturation of 30S ribosomal subunits
SynROS8604_03161	COG0195	Participates in both transcription termination and antitermination
SynROS8604_03163	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynROS8604_03181	COG2988	succinylglutamate desuccinylase activity
SynROS8604_03182	COG0435	Glutathione S-transferase
SynROS8604_03184	COG0488	(ABC) transporter
SynROS8604_03186	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynROS8604_03187	COG3842	ATPase activity
SynROS8604_03188	COG1193	negative regulation of DNA recombination
SynROS8604_03190	COG0113	porphobilinogen synthase activity
SynROS8604_03191	COG0484	heat shock protein binding
SynROS8604_03193	COG0659	secondary active sulfate transmembrane transporter activity
SynROS8604_03224	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynROS8604_03232	COG0242	peptide deformylase activity
SynROS8604_03268	COG0116	Belongs to the methyltransferase superfamily
SynROS8604_03272	COG1196	nuclear chromosome segregation
SynROS8604_03274	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynROS8604_03277	COG0439	Biotin carboxylase
SynROS8604_03281	COG0515	serine threonine protein kinase
SynROS8604_03284	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynROS8604_03285	COG4178	(ABC) transporter
SynROS8604_03286	COG0537	adenosine 5'-monophosphoramidase activity
SynROS8604_03288	COG0606	chelatase, subunit chli
SynROS8604_03290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynROS8604_03293	COG0242	peptide deformylase activity
SynROS8604_03295	COG0235	Class ii aldolase
SynROS8604_03296	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynROS8604_03300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynROS8604_03301	COG0719	Fe-S assembly protein
SynROS8604_03302	COG0396	ATPase activity
SynROS8604_03303	COG0719	Fe-S assembly protein
SynROS8604_03304	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynROS8604_03309	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynROS8604_03331	COG2814	Major facilitator Superfamily
SynROS8604_03333	COG0033	Phosphoglucomutase
SynROS8604_03336	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynROS8604_03341	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynROS8604_03342	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynROS8604_03343	COG0175	sulfate reduction
SynROS8604_03344	COG1252	NADH dehydrogenase
SynROS8604_03345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynROS8604_03347	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynROS8604_03348	COG0569	domain protein
SynROS8604_03349	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynROS8604_03355	COG0488	(ABC) transporter
SynROS8604_03357	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynROS8604_03360	COG1643	Atp-dependent helicase
SynROS8604_03361	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynROS8604_03363	COG1570	exodeoxyribonuclease VII activity
SynROS8604_03364	COG1722	exodeoxyribonuclease VII activity
SynROS8604_03374	COG0483	inositol monophosphate 1-phosphatase activity
SynROS8604_03375	COG1538	Outer membrane efflux protein
SynROS8604_03377	COG1968	undecaprenyl-diphosphatase activity
SynROS8604_03380	COG1555	photosystem II stabilization
SynROS8604_03381	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynROS8604_03382	COG4243	Vitamin k epoxide reductase
SynROS8604_03384	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynROS8604_03386	COG1032	radical SAM domain protein
SynROS8604_03396	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynROS8604_03398	COG0457	Tetratricopeptide repeat
SynROS8604_03398	COG0463	Glycosyl transferase, family 2
SynROS8604_03399	COG1587	Uroporphyrinogen-III synthase
SynROS8604_03402	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynROS8604_03403	COG0316	Belongs to the HesB IscA family
SynROS8604_03406	COG1090	epimerase
SynROS8604_03407	COG3263	regulation of cellular component size
SynROS8604_03410	COG0484	heat shock protein binding
SynROS8604_03411	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynROS8604_03412	COG3659	wide pore channel activity
SynROS8604_03414	COG3659	wide pore channel activity
SynROS8604_03428	COG1122	ATPase activity
SynROS8604_03431	COG0745	RESPONSE REGULATOR receiver
SynROS8604_03433	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynROS8604_03434	COG2217	Heavy metal translocating P-type atpase
SynROS8604_03435	COG3063	Type IV pilus biogenesis stability protein PilW
SynROS8604_03436	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynROS8604_03438	COG0416	fatty acid biosynthetic process
SynROS8604_03439	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynROS8604_03440	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynROS8604_03441	COG0204	Acyl-transferase
SynROS8604_03441	COG0318	PFAM AMP-dependent synthetase and ligase
SynROS8604_03443	COG1214	PFAM Peptidase M22, glycoprotease
SynROS8604_03445	COG0617	tRNA 3'-terminal CCA addition
SynROS8604_03447	COG1562	ergosterol biosynthetic process
SynROS8604_03448	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynROS8604_03448	COG0493	'glutamate synthase
SynROS8604_03451	COG0583	DNA-binding transcription factor activity
SynROS8604_03453	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynROS8604_03454	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynROS8604_03455	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynROS8604_03458	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynROS8604_03463	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynROS8604_03464	COG0713	ATP synthesis coupled electron transport
SynROS8604_03465	COG0839	Belongs to the complex I subunit 6 family
SynROS8604_03466	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynROS8604_03467	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynROS8604_03468	COG0372	Belongs to the citrate synthase family
SynROS8604_03472	COG1420	regulation of RNA biosynthetic process
SynROS8604_03475	COG0133	tryptophan synthase activity
SynROS8604_03476	COG1073	alpha beta
SynROS8604_03476	COG2226	methyltransferase
SynROS8604_03477	COG0023	Translation Initiation Factor
SynROS8604_03478	COG0529	Catalyzes the synthesis of activated sulfate
SynROS8604_03479	COG0628	permease
SynROS8604_03480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynROS8604_03482	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynROS8604_03483	COG0564	pseudouridine synthase activity
SynROS8604_03484	COG0745	RESPONSE REGULATOR receiver
SynROS8604_03486	COG1104	cysteine desulfurase activity
SynROS8604_03489	COG0275	rRNA processing
SynROS8604_03490	COG0649	NAD binding
SynROS8604_03492	COG0824	Thioesterase
SynROS8604_03496	COG4948	Mandelate Racemase Muconate Lactonizing
SynROS8604_03497	COG1575	Belongs to the MenA family. Type 1 subfamily
SynROS8604_03499	COG0189	ligase activity
SynROS8604_03500	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynROS8604_03501	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynROS8604_03503	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynROS8604_03504	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynROS8604_03507	COG0252	asparaginase activity
SynROS8604_03508	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynROS8604_03511	COG0018	arginyl-trna synthetase
SynROS8604_03527	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynROS8604_03531	COG0668	transmembrane transport
SynROS8604_03538	COG0157	Belongs to the NadC ModD family
SynROS8604_03539	COG0154	amidase activity
SynROS8604_03543	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynROS8604_03545	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SynROS8604_03546	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynROS8604_03547	COG4172	Belongs to the ABC transporter superfamily
SynROS8604_03548	COG2197	response regulator
SynROS8604_03551	COG0564	pseudouridine synthase activity
SynROS8604_03553	COG0589	response to stress
SynROS8604_03554	COG0126	phosphoglycerate kinase activity
SynROS8604_03557	COG2084	Dehydrogenase
SynROS8604_03559	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynROS8604_03560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynROS8604_03566	COG0167	dihydroorotate dehydrogenase activity
SynROS8604_03567	COG0328	RNA-DNA hybrid ribonuclease activity
SynROS8604_03570	COG0222	ribosome binding
SynROS8604_03571	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynROS8604_03572	COG0081	regulation of translation
SynROS8604_03573	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynROS8604_03574	COG0250	Participates in transcription elongation, termination and antitermination
SynROS8604_03575	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynROS8604_03576	COG0542	response to heat
SynROS8604_03577	COG0346	lactoylglutathione lyase activity
SynROS8604_03578	COG0148	phosphopyruvate hydratase activity
SynROS8604_03579	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynROS8604_03594	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynROS8604_03596	COG0237	dephospho-CoA kinase activity
SynROS8604_03599	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynROS8604_03602	COG2022	thiamine diphosphate biosynthetic process
SynROS8604_03602	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynROS8604_03603	COG0105	UTP biosynthetic process
SynROS8604_03604	COG1166	arginine decarboxylase activity
SynROS8604_03607	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynROS8604_03609	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynROS8604_03611	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynROS8604_03617	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SynROS8604_03619	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SynROS8604_03620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynROS8604_03620	COG0426	domain, Protein
SynROS8604_03621	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynROS8604_03621	COG0426	domain, Protein
SynROS8604_03622	COG1773	rubredoxin
SynROS8604_03624	COG1741	Belongs to the pirin family
SynROS8604_03629	COG0509	glycine decarboxylation via glycine cleavage system
SynROS8604_03630	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynROS8604_03634	COG0359	binds to the 23S rRNA
SynROS8604_03635	COG0305	Participates in initiation and elongation during chromosome replication
SynROS8604_03635	COG1372	Participates in initiation and elongation during chromosome replication
SynROS8604_03635	COG0305	Participates in initiation and elongation during chromosome replication
SynROS8604_03635	COG1372	Participates in initiation and elongation during chromosome replication
SynROS8604_03642	COG0445	tRNA wobble uridine modification
SynROS8604_03654	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynROS8604_03657	COG0398	Pfam SNARE associated Golgi protein
SynROS8604_03661	COG1131	(ABC) transporter
SynROS8604_03662	COG0668	transmembrane transport
SynROS8604_03663	COG0525	valine-tRNA ligase activity
SynROS8604_03668	COG4221	oxidoreductase activity
SynROS8604_03682	COG3956	TIGRFAM MazG family protein
SynROS8604_03683	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynROS8604_03684	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynROS8604_03685	COG0010	Belongs to the arginase family
SynROS8604_03688	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynROS8604_03689	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynROS8604_03690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynROS8604_03691	COG0783	Belongs to the Dps family
SynROS8604_03693	COG0504	CTP synthase activity
SynROS8604_03694	COG0602	queuosine metabolic process
SynROS8604_03695	COG4574	serine-type endopeptidase inhibitor activity
SynROS8604_03696	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynROS8604_03699	COG0531	amino acid
SynROS8604_03706	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynROS8604_03707	COG0830	nickel cation binding
SynROS8604_03708	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynROS8604_03710	COG0829	nickel cation binding
SynROS8604_03711	COG0831	urea catabolic process
SynROS8604_03712	COG0832	Belongs to the urease beta subunit family
SynROS8604_03713	COG0804	urea catabolic process
SynROS8604_03715	COG2308	Evidence 4 Homologs of previously reported genes of
SynROS8604_03719	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynROS8604_03720	COG0746	molybdenum cofactor guanylyltransferase activity
SynROS8604_03721	COG2223	nitrite transmembrane transporter activity
SynROS8604_03722	COG0243	molybdopterin cofactor binding
SynROS8604_03726	COG0315	cyclic pyranopterin monophosphate synthase activity
SynROS8604_03730	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynROS8604_03731	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynROS8604_03735	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynROS8604_03737	COG2116	formate transmembrane transporter activity
SynROS8604_03739	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynROS8604_03741	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynROS8604_03743	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynROS8604_03744	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynROS8604_03745	COG0170	dolichyl monophosphate biosynthetic process
SynROS8604_03746	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynROS8604_03747	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynROS8604_03751	COG0788	formyltetrahydrofolate deformylase activity
SynROS8604_03753	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynROS8604_03755	COG3659	wide pore channel activity
SynROS8604_03758	COG0443	Heat shock 70 kDa protein
SynROS8604_03759	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynROS8604_03761	COG0360	Binds together with S18 to 16S ribosomal RNA
SynROS8604_03763	COG0137	argininosuccinate synthase activity
SynROS8604_03766	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynROS8604_03769	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynROS8604_03770	COG0438	transferase activity, transferring glycosyl groups
SynROS8604_03773	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynROS8604_03774	COG0497	DNA recombination
SynROS8604_03775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynROS8604_03777	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine