locus-tag	class	description
SynRS9909_00001	COG0592	DNA-directed DNA polymerase activity
SynRS9909_00003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynRS9909_00004	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynRS9909_00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynRS9909_00007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynRS9909_00010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynRS9909_00011	COG0552	protein localization to endoplasmic reticulum
SynRS9909_00012	COG2208	phosphoserine phosphatase activity
SynRS9909_00013	COG0165	Argininosuccinate lyase
SynRS9909_00014	COG0724	RNA recognition motif
SynRS9909_00015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynRS9909_00016	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynRS9909_00017	COG2081	HI0933 family
SynRS9909_00018	COG1459	type II secretion system
SynRS9909_00020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynRS9909_00021	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynRS9909_00022	COG0484	heat shock protein binding
SynRS9909_00024	COG1162	GTPase activity
SynRS9909_00025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynRS9909_00026	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynRS9909_00027	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynRS9909_00028	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynRS9909_00029	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynRS9909_00030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynRS9909_00031	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynRS9909_00032	COG0511	ligase activity, forming carbon-carbon bonds
SynRS9909_00033	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynRS9909_00048	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynRS9909_00048	COG0519	Catalyzes the synthesis of GMP from XMP
SynRS9909_00051	COG0768	penicillin binding
SynRS9909_00052	COG0438	transferase activity, transferring glycosyl groups
SynRS9909_00053	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynRS9909_00055	COG2022	thiamine diphosphate biosynthetic process
SynRS9909_00058	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynRS9909_00059	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynRS9909_00060	COG2385	sporulation resulting in formation of a cellular spore
SynRS9909_00061	COG1215	transferase activity, transferring glycosyl groups
SynRS9909_00064	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynRS9909_00066	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynRS9909_00067	COG0740	serine-type endopeptidase activity
SynRS9909_00068	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynRS9909_00069	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynRS9909_00070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynRS9909_00071	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynRS9909_00073	COG0037	tRNA processing
SynRS9909_00078	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynRS9909_00081	COG0556	nucleotide-excision repair
SynRS9909_00088	COG2082	Precorrin-8x methylmutase
SynRS9909_00090	COG2274	protein secretion by the type I secretion system
SynRS9909_00093	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynRS9909_00096	COG0653	protein targeting
SynRS9909_00098	COG1045	serine acetyltransferase
SynRS9909_00101	COG1725	Transcriptional regulator
SynRS9909_00102	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynRS9909_00103	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynRS9909_00104	COG0187	DNA topoisomerase II activity
SynRS9909_00104	COG1372	Participates in initiation and elongation during chromosome replication
SynRS9909_00106	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynRS9909_00107	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynRS9909_00108	COG0386	Belongs to the glutathione peroxidase family
SynRS9909_00109	COG2239	Acts as a magnesium transporter
SynRS9909_00110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynRS9909_00111	COG2267	carboxylic ester hydrolase activity
SynRS9909_00115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynRS9909_00117	COG2072	flavoprotein involved in K transport
SynRS9909_00119	COG3961	Belongs to the TPP enzyme family
SynRS9909_00122	COG0802	atpase or kinase
SynRS9909_00123	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynRS9909_00124	COG0586	Pfam SNARE associated Golgi protein
SynRS9909_00125	COG0629	single-stranded DNA binding
SynRS9909_00130	COG0745	RESPONSE REGULATOR receiver
SynRS9909_00131	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynRS9909_00135	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynRS9909_00136	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynRS9909_00137	COG0515	serine threonine protein kinase
SynRS9909_00138	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynRS9909_00139	COG2255	four-way junction helicase activity
SynRS9909_00141	COG1473	amidohydrolase
SynRS9909_00145	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynRS9909_00146	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynRS9909_00147	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynRS9909_00148	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynRS9909_00149	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynRS9909_00150	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9909_00151	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynRS9909_00153	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynRS9909_00157	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynRS9909_00160	COG0571	ribonuclease III activity
SynRS9909_00165	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SynRS9909_00166	COG0058	SHG alpha-glucan phosphorylase activity
SynRS9909_00167	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SynRS9909_00168	COG0475	glutathione-regulated potassium exporter activity
SynRS9909_00172	COG0277	FAD linked oxidase domain protein
SynRS9909_00174	COG0247	lactate metabolic process
SynRS9909_00178	COG0538	isocitrate dehydrogenase activity
SynRS9909_00179	COG0463	Glycosyl transferase, family 2
SynRS9909_00182	COG5398	heme oxygenase
SynRS9909_00184	COG1132	(ABC) transporter
SynRS9909_00185	COG0438	transferase activity, transferring glycosyl groups
SynRS9909_00186	COG0438	transferase activity, transferring glycosyl groups
SynRS9909_00188	COG0438	transferase activity, transferring glycosyl groups
SynRS9909_00192	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynRS9909_00194	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynRS9909_00196	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynRS9909_00200	COG0617	tRNA 3'-terminal CCA addition
SynRS9909_00200	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SynRS9909_00200	COG0517	IMP dehydrogenase activity
SynRS9909_00207	COG0709	Synthesizes selenophosphate from selenide and ATP
SynRS9909_00209	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynRS9909_00219	COG1132	(ABC) transporter
SynRS9909_00220	COG1086	Polysaccharide biosynthesis protein
SynRS9909_00222	COG2089	acid synthase
SynRS9909_00224	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SynRS9909_00225	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynRS9909_00228	COG2801	Transposase and inactivated derivatives
SynRS9909_00233	COG4106	trans-aconitate 2-methyltransferase activity
SynRS9909_00234	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynRS9909_00243	COG0438	transferase activity, transferring glycosyl groups
SynRS9909_00244	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynRS9909_00246	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SynRS9909_00254	COG2337	Toxic component of a toxin-antitoxin (TA) module
SynRS9909_00269	COG0124	histidyl-tRNA synthetase
SynRS9909_00271	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynRS9909_00278	COG4447	cellulose binding
SynRS9909_00279	COG1773	rubredoxin
SynRS9909_00280	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9909_00281	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9909_00282	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9909_00283	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynRS9909_00284	COG3842	ATPase activity
SynRS9909_00285	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SynRS9909_00286	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynRS9909_00286	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynRS9909_00290	COG0494	nUDIX hydrolase
SynRS9909_00291	COG0415	Belongs to the DNA photolyase family
SynRS9909_00296	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynRS9909_00297	COG0131	Imidazoleglycerol-phosphate dehydratase
SynRS9909_00298	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynRS9909_00301	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynRS9909_00305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynRS9909_00306	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynRS9909_00308	COG0354	folic acid binding
SynRS9909_00312	COG0582	viral genome integration into host DNA
SynRS9909_00323	COG1401	restriction endodeoxyribonuclease activity
SynRS9909_00339	COG1484	DNA-dependent DNA replication
SynRS9909_00340	COG4584	PFAM Integrase catalytic
SynRS9909_00365	COG2801	Transposase and inactivated derivatives
SynRS9909_00371	COG1253	flavin adenine dinucleotide binding
SynRS9909_00372	COG0673	inositol 2-dehydrogenase activity
SynRS9909_00376	COG0343	queuine tRNA-ribosyltransferase activity
SynRS9909_00381	COG0138	bifunctional purine biosynthesis protein purh
SynRS9909_00384	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynRS9909_00385	COG0004	ammonium transporteR
SynRS9909_00387	COG1489	DNA binding
SynRS9909_00388	COG0728	peptidoglycan biosynthetic process
SynRS9909_00393	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynRS9909_00394	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynRS9909_00395	COG1546	Belongs to the CinA family
SynRS9909_00395	COG1058	Belongs to the CinA family
SynRS9909_00396	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SynRS9909_00397	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynRS9909_00398	COG0066	3-isopropylmalate dehydratase activity
SynRS9909_00406	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynRS9909_00407	COG0193	aminoacyl-tRNA hydrolase activity
SynRS9909_00410	COG4372	Transposase
SynRS9909_00411	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynRS9909_00412	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynRS9909_00414	COG0717	Belongs to the dCTP deaminase family
SynRS9909_00416	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynRS9909_00421	COG2971	BadF BadG BcrA BcrD
SynRS9909_00423	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynRS9909_00427	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynRS9909_00431	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynRS9909_00432	COG1402	creatininase
SynRS9909_00434	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynRS9909_00435	COG2094	Belongs to the DNA glycosylase MPG family
SynRS9909_00436	COG0540	Belongs to the ATCase OTCase family
SynRS9909_00445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynRS9909_00448	COG0529	Catalyzes the synthesis of activated sulfate
SynRS9909_00448	COG2046	Belongs to the sulfate adenylyltransferase family
SynRS9909_00449	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynRS9909_00452	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynRS9909_00453	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynRS9909_00454	COG2226	methyltransferase
SynRS9909_00455	COG4175	Glycine betaine
SynRS9909_00456	COG4176	ABC-type proline glycine betaine transport system permease component
SynRS9909_00457	COG2113	Glycine betaine
SynRS9909_00458	COG0463	Glycosyl transferase, family 2
SynRS9909_00459	COG0366	Alpha amylase catalytic
SynRS9909_00463	COG0028	Belongs to the TPP enzyme family
SynRS9909_00467	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynRS9909_00468	COG0436	Aminotransferase
SynRS9909_00470	COG1530	ribonuclease E activity
SynRS9909_00471	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynRS9909_00473	COG1605	Chorismate mutase
SynRS9909_00473	COG0077	Prephenate dehydratase
SynRS9909_00474	COG2226	methyltransferase
SynRS9909_00475	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynRS9909_00476	COG0051	transcription antitermination factor activity, RNA binding
SynRS9909_00477	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynRS9909_00478	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynRS9909_00479	COG0049	tRNA binding
SynRS9909_00480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynRS9909_00483	COG0070	glutamate synthase
SynRS9909_00483	COG0069	glutamate synthase activity
SynRS9909_00483	COG0067	glutamate synthase
SynRS9909_00489	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynRS9909_00493	COG2885	chlorophyll binding
SynRS9909_00494	COG2885	chlorophyll binding
SynRS9909_00497	COG3239	Fatty acid desaturase
SynRS9909_00502	COG0463	Glycosyl transferase, family 2
SynRS9909_00506	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynRS9909_00508	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynRS9909_00509	COG0254	rRNA binding
SynRS9909_00510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynRS9909_00511	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynRS9909_00514	COG0202	RNA polymerase activity
SynRS9909_00515	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynRS9909_00516	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynRS9909_00517	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynRS9909_00518	COG0563	adenylate kinase activity
SynRS9909_00519	COG0201	protein transport
SynRS9909_00520	COG0200	Binds to the 23S rRNA
SynRS9909_00521	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynRS9909_00522	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynRS9909_00523	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynRS9909_00524	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynRS9909_00525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynRS9909_00526	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynRS9909_00527	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynRS9909_00528	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynRS9909_00529	COG0255	Belongs to the universal ribosomal protein uL29 family
SynRS9909_00530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynRS9909_00531	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynRS9909_00532	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynRS9909_00533	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynRS9909_00534	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynRS9909_00535	COG0089	rRNA binding
SynRS9909_00536	COG0088	Forms part of the polypeptide exit tunnel
SynRS9909_00537	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynRS9909_00540	COG3854	ATPases associated with a variety of cellular activities
SynRS9909_00543	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynRS9909_00549	COG3001	Fructosamine kinase
SynRS9909_00553	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynRS9909_00554	COG0475	glutathione-regulated potassium exporter activity
SynRS9909_00554	COG0569	domain protein
SynRS9909_00555	COG1606	tRNA processing
SynRS9909_00556	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynRS9909_00557	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynRS9909_00560	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynRS9909_00562	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynRS9909_00565	COG0772	Belongs to the SEDS family
SynRS9909_00566	COG0489	protein tyrosine kinase activity
SynRS9909_00567	COG0408	coproporphyrinogen oxidase activity
SynRS9909_00580	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynRS9909_00581	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynRS9909_00582	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynRS9909_00582	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynRS9909_00583	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynRS9909_00593	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynRS9909_00600	COG1070	Carbohydrate kinase
SynRS9909_00601	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynRS9909_00603	COG0539	negative regulation of cytoplasmic translation
SynRS9909_00604	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynRS9909_00608	COG0589	response to stress
SynRS9909_00610	COG0758	DNA mediated transformation
SynRS9909_00611	COG2890	protein-(glutamine-N5) methyltransferase activity
SynRS9909_00612	COG0009	L-threonylcarbamoyladenylate synthase
SynRS9909_00615	COG2197	response regulator
SynRS9909_00616	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynRS9909_00617	COG2894	cell division
SynRS9909_00618	COG0850	regulation of cytokinetic process
SynRS9909_00621	COG2059	Chromate
SynRS9909_00622	COG1078	dGTPase activity
SynRS9909_00623	COG0793	Belongs to the peptidase S41A family
SynRS9909_00624	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynRS9909_00625	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynRS9909_00632	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynRS9909_00633	COG0235	Class ii aldolase
SynRS9909_00634	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynRS9909_00637	COG0514	ATP-dependent DNA helicase (RecQ)
SynRS9909_00638	COG3942	CHAP domain
SynRS9909_00638	COG1388	LysM domain
SynRS9909_00639	COG1012	belongs to the aldehyde dehydrogenase family
SynRS9909_00641	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynRS9909_00642	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynRS9909_00650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynRS9909_00653	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynRS9909_00658	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynRS9909_00661	COG1376	ErfK ybiS ycfS ynhG family protein
SynRS9909_00662	COG1160	GTP binding
SynRS9909_00663	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynRS9909_00665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynRS9909_00666	COG1799	cell septum assembly
SynRS9909_00667	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynRS9909_00668	COG0438	transferase activity, transferring glycosyl groups
SynRS9909_00670	COG1381	Involved in DNA repair and RecF pathway recombination
SynRS9909_00671	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynRS9909_00672	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynRS9909_00673	COG0321	lipoyl(octanoyl) transferase activity
SynRS9909_00674	COG1022	Amp-dependent synthetase and ligase
SynRS9909_00676	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynRS9909_00678	COG0531	amino acid
SynRS9909_00679	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynRS9909_00680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynRS9909_00686	COG1596	polysaccharide export
SynRS9909_00688	COG0489	protein tyrosine kinase activity
SynRS9909_00689	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynRS9909_00692	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynRS9909_00695	COG4067	protein conserved in archaea
SynRS9909_00695	COG0189	ligase activity
SynRS9909_00697	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynRS9909_00698	COG0579	oxidoreductase
SynRS9909_00702	COG0481	GTPase activity
SynRS9909_00710	COG5002	protein histidine kinase activity
SynRS9909_00711	COG0745	RESPONSE REGULATOR receiver
SynRS9909_00716	COG2205	protein histidine kinase activity
SynRS9909_00719	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynRS9909_00721	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynRS9909_00721	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynRS9909_00722	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynRS9909_00723	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynRS9909_00725	COG0107	imidazoleglycerol-phosphate synthase activity
SynRS9909_00727	COG2226	methyltransferase
SynRS9909_00729	COG0752	glycyl-tRNA synthetase alpha subunit
SynRS9909_00738	COG2217	Heavy metal translocating P-type atpase
SynRS9909_00746	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynRS9909_00747	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynRS9909_00748	COG0740	serine-type endopeptidase activity
SynRS9909_00749	COG0740	serine-type endopeptidase activity
SynRS9909_00750	COG4956	integral membrane protein (PIN domain superfamily)
SynRS9909_00751	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynRS9909_00752	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynRS9909_00753	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynRS9909_00756	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynRS9909_00757	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynRS9909_00758	COG4948	Mandelate Racemase Muconate Lactonizing
SynRS9909_00765	COG0285	dihydrofolate synthase activity
SynRS9909_00766	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynRS9909_00767	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynRS9909_00768	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynRS9909_00771	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynRS9909_00772	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynRS9909_00773	COG0134	indole-3-glycerol-phosphate synthase activity
SynRS9909_00775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SynRS9909_00778	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynRS9909_00779	COG0482	sulfurtransferase activity
SynRS9909_00780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynRS9909_00780	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynRS9909_00781	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynRS9909_00782	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynRS9909_00784	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynRS9909_00786	COG1702	phosphate starvation-inducible protein PhoH
SynRS9909_00788	COG0477	Major facilitator Superfamily
SynRS9909_00791	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynRS9909_00793	COG0336	Belongs to the RNA methyltransferase TrmD family
SynRS9909_00794	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SynRS9909_00796	COG1691	(AIR) carboxylase
SynRS9909_00801	COG0352	thiamine-phosphate diphosphorylase activity
SynRS9909_00803	COG0196	riboflavin kinase activity
SynRS9909_00805	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynRS9909_00806	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynRS9909_00807	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynRS9909_00808	COG0745	RESPONSE REGULATOR receiver
SynRS9909_00818	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynRS9909_00818	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynRS9909_00822	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynRS9909_00823	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynRS9909_00824	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynRS9909_00832	COG0477	Major facilitator Superfamily
SynRS9909_00833	COG0432	Pfam Uncharacterised protein family UPF0047
SynRS9909_00839	COG1492	cobalamin metabolic process
SynRS9909_00843	COG0424	maF-like protein
SynRS9909_00844	COG3550	peptidyl-serine autophosphorylation
SynRS9909_00853	COG0424	maF-like protein
SynRS9909_00860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynRS9909_00861	COG0440	acetolactate synthase activity
SynRS9909_00862	COG2267	carboxylic ester hydrolase activity
SynRS9909_00867	COG2226	methyltransferase
SynRS9909_00870	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynRS9909_00871	COG0492	ferredoxin-NADP+ reductase activity
SynRS9909_00880	COG3411	Ferredoxin
SynRS9909_00881	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynRS9909_00882	COG0733	neurotransmitter:sodium symporter activity
SynRS9909_00885	COG0215	cysteine-tRNA ligase activity
SynRS9909_00886	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynRS9909_00886	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynRS9909_00888	COG0012	GTP binding
SynRS9909_00890	COG4191	Histidine kinase
SynRS9909_00899	COG2197	response regulator
SynRS9909_00905	COG0601	transmembrane transport
SynRS9909_00908	COG0460	homoserine dehydrogenase
SynRS9909_00909	COG2166	iron-sulfur cluster assembly
SynRS9909_00912	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynRS9909_00913	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynRS9909_00914	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynRS9909_00917	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SynRS9909_00918	COG2010	Cytochrome c
SynRS9909_00920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynRS9909_00921	COG3118	belongs to the thioredoxin family
SynRS9909_00922	COG0516	GMP reductase activity
SynRS9909_00924	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynRS9909_00926	COG0644	oxidoreductase
SynRS9909_00927	COG1543	Belongs to the glycosyl hydrolase 57 family
SynRS9909_00928	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynRS9909_00929	COG0395	ABC-type sugar transport system, permease component
SynRS9909_00934	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynRS9909_00938	COG0011	TIGRFAM Protein of
SynRS9909_00942	COG1480	7TM receptor with intracellular HD hydrolase
SynRS9909_00943	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynRS9909_00946	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynRS9909_00948	COG0406	alpha-ribazole phosphatase activity
SynRS9909_00949	COG1254	Belongs to the acylphosphatase family
SynRS9909_00950	COG1797	cobyrinic acid a,c-diamide synthase activity
SynRS9909_00951	COG3409	Peptidoglycan-binding domain 1 protein
SynRS9909_00951	COG3429	Glucose-6-phosphate dehydrogenase subunit
SynRS9909_00952	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynRS9909_00957	COG2205	protein histidine kinase activity
SynRS9909_00960	COG0308	aminopeptidase N
SynRS9909_00962	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynRS9909_00964	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
SynRS9909_00965	COG1640	4-alpha-glucanotransferase
SynRS9909_00967	COG1187	pseudouridine synthase activity
SynRS9909_00968	COG5002	protein histidine kinase activity
SynRS9909_00969	COG0745	RESPONSE REGULATOR receiver
SynRS9909_00970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynRS9909_00972	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynRS9909_00973	COG1982	Orn Lys Arg decarboxylase major
SynRS9909_00974	COG0575	Belongs to the CDS family
SynRS9909_00976	COG2267	carboxylic ester hydrolase activity
SynRS9909_00977	COG0371	Dehydrogenase
SynRS9909_00978	COG0542	response to heat
SynRS9909_00980	COG0019	diaminopimelate decarboxylase activity
SynRS9909_00981	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynRS9909_00982	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynRS9909_00983	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynRS9909_00984	COG1054	Belongs to the UPF0176 family
SynRS9909_00988	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynRS9909_00989	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynRS9909_00997	COG0475	glutathione-regulated potassium exporter activity
SynRS9909_00997	COG0589	response to stress
SynRS9909_00998	COG1132	(ABC) transporter
SynRS9909_01000	COG0724	RNA recognition motif
SynRS9909_01003	COG0513	Belongs to the DEAD box helicase family
SynRS9909_01005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynRS9909_01007	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynRS9909_01012	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynRS9909_01015	COG0271	Belongs to the BolA IbaG family
SynRS9909_01016	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynRS9909_01018	COG0745	RESPONSE REGULATOR receiver
SynRS9909_01023	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynRS9909_01025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynRS9909_01035	COG0644	oxidoreductase
SynRS9909_01040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynRS9909_01042	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynRS9909_01043	COG0640	Transcriptional regulator
SynRS9909_01044	COG0798	PFAM Bile acid sodium symporter
SynRS9909_01046	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynRS9909_01047	COG2814	Major facilitator Superfamily
SynRS9909_01049	COG3659	wide pore channel activity
SynRS9909_01050	COG2197	response regulator
SynRS9909_01061	COG1525	nuclease
SynRS9909_01065	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynRS9909_01075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SynRS9909_01088	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SynRS9909_01097	COG1115	amino acid carrier protein
SynRS9909_01099	COG0450	alkyl hydroperoxide reductase
SynRS9909_01100	COG1615	UPF0182 protein
SynRS9909_01101	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynRS9909_01102	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynRS9909_01105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynRS9909_01106	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynRS9909_01106	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynRS9909_01110	COG2119	membrane
SynRS9909_01112	COG0557	exoribonuclease II activity
SynRS9909_01113	COG0163	prenyltransferase activity
SynRS9909_01116	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynRS9909_01118	COG0312	modulator of DNA gyrase
SynRS9909_01120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynRS9909_01121	COG0513	Belongs to the DEAD box helicase family
SynRS9909_01124	COG0861	Integral membrane protein TerC family
SynRS9909_01126	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynRS9909_01128	COG0793	Belongs to the peptidase S41A family
SynRS9909_01129	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynRS9909_01130	COG1573	uracil-dna glycosylase
SynRS9909_01131	COG0436	Aminotransferase
SynRS9909_01132	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynRS9909_01133	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynRS9909_01133	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynRS9909_01134	COG3639	organic phosphonate transmembrane transporter activity
SynRS9909_01137	COG1836	PFAM Integral membrane protein DUF92
SynRS9909_01141	COG1122	ATPase activity
SynRS9909_01142	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynRS9909_01145	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynRS9909_01146	COG4106	trans-aconitate 2-methyltransferase activity
SynRS9909_01151	COG0582	viral genome integration into host DNA
SynRS9909_01191	COG3093	addiction module antidote protein HigA
SynRS9909_01198	COG2801	Transposase and inactivated derivatives
SynRS9909_01202	COG2801	Transposase and inactivated derivatives
SynRS9909_01231	COG1051	belongs to the nudix hydrolase family
SynRS9909_01257	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynRS9909_01258	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynRS9909_01260	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynRS9909_01261	COG1429	ligase activity, forming nitrogen-metal bonds
SynRS9909_01262	COG5001	Diguanylate cyclase
SynRS9909_01263	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynRS9909_01264	COG0149	triose-phosphate isomerase activity
SynRS9909_01266	COG1132	(ABC) transporter
SynRS9909_01268	COG1115	amino acid carrier protein
SynRS9909_01270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynRS9909_01277	COG1484	DNA-dependent DNA replication
SynRS9909_01278	COG4584	PFAM Integrase catalytic
SynRS9909_01297	COG2132	Multicopper oxidase
SynRS9909_01308	COG4584	PFAM Integrase catalytic
SynRS9909_01309	COG1484	DNA-dependent DNA replication
SynRS9909_01310	COG3772	lysozyme
SynRS9909_01353	COG0659	secondary active sulfate transmembrane transporter activity
SynRS9909_01357	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynRS9909_01358	COG4597	amino acid ABC transporter
SynRS9909_01360	COG0765	amino acid transport
SynRS9909_01361	COG1126	abc transporter atp-binding protein
SynRS9909_01367	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynRS9909_01368	COG2873	o-acetylhomoserine
SynRS9909_01373	COG0420	3'-5' exonuclease activity
SynRS9909_01376	COG0625	glutathione transferase activity
SynRS9909_01384	COG0735	belongs to the Fur family
SynRS9909_01385	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynRS9909_01389	COG0259	pyridoxamine-phosphate oxidase activity
SynRS9909_01391	COG0723	plastoquinol--plastocyanin reductase activity
SynRS9909_01400	COG1136	(ABC) transporter
SynRS9909_01400	COG0577	efflux transmembrane transporter activity
SynRS9909_01407	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynRS9909_01409	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynRS9909_01412	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynRS9909_01417	COG3275	phosphorelay sensor kinase activity
SynRS9909_01424	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynRS9909_01424	COG0426	domain, Protein
SynRS9909_01428	COG0739	heme binding
SynRS9909_01429	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynRS9909_01435	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynRS9909_01438	COG0557	exoribonuclease II activity
SynRS9909_01439	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynRS9909_01440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynRS9909_01441	COG0072	phenylalanine-tRNA ligase activity
SynRS9909_01441	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynRS9909_01442	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynRS9909_01449	COG2385	sporulation resulting in formation of a cellular spore
SynRS9909_01455	COG1410	methionine synthase
SynRS9909_01455	COG0646	methionine synthase
SynRS9909_01456	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynRS9909_01459	COG0613	PHP domain protein
SynRS9909_01460	COG1981	membrane
SynRS9909_01461	COG3046	protein related to deoxyribodipyrimidine photolyase
SynRS9909_01463	COG0322	excinuclease ABC activity
SynRS9909_01470	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynRS9909_01472	COG0495	leucyl-tRNA aminoacylation
SynRS9909_01473	COG0166	Belongs to the GPI family
SynRS9909_01478	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynRS9909_01479	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynRS9909_01480	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynRS9909_01480	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynRS9909_01481	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynRS9909_01482	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynRS9909_01483	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynRS9909_01485	COG0484	heat shock protein binding
SynRS9909_01486	COG0443	Heat shock 70 kDa protein
SynRS9909_01487	COG0573	inorganic phosphate transmembrane transporter activity
SynRS9909_01488	COG0581	inorganic phosphate transmembrane transporter activity
SynRS9909_01489	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynRS9909_01491	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynRS9909_01492	COG0483	inositol monophosphate 1-phosphatase activity
SynRS9909_01495	COG0326	Molecular chaperone. Has ATPase activity
SynRS9909_01496	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynRS9909_01497	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynRS9909_01498	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynRS9909_01499	COG1653	transport
SynRS9909_01505	COG0598	Magnesium transport protein CorA
SynRS9909_01506	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynRS9909_01511	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynRS9909_01512	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynRS9909_01516	COG0469	pyruvate kinase activity
SynRS9909_01517	COG1136	(ABC) transporter
SynRS9909_01517	COG0577	efflux transmembrane transporter activity
SynRS9909_01518	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynRS9909_01520	COG0740	serine-type endopeptidase activity
SynRS9909_01525	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynRS9909_01526	COG2211	Major facilitator Superfamily
SynRS9909_01529	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynRS9909_01530	COG1175	transmembrane transport
SynRS9909_01531	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynRS9909_01538	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SynRS9909_01538	COG1793	dna ligase
SynRS9909_01540	COG1793	dna ligase
SynRS9909_01541	COG1201	RNA secondary structure unwinding
SynRS9909_01549	COG3659	wide pore channel activity
SynRS9909_01553	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynRS9909_01558	COG1376	ErfK ybiS ycfS ynhG family protein
SynRS9909_01561	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SynRS9909_01565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynRS9909_01567	COG2197	response regulator
SynRS9909_01568	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynRS9909_01571	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynRS9909_01574	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynRS9909_01575	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynRS9909_01576	COG0473	3-isopropylmalate dehydrogenase activity
SynRS9909_01577	COG3954	Phosphoribulokinase
SynRS9909_01579	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynRS9909_01580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynRS9909_01582	COG0673	inositol 2-dehydrogenase activity
SynRS9909_01583	COG0191	fructose-bisphosphate aldolase activity
SynRS9909_01584	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynRS9909_01585	COG0047	phosphoribosylformylglycinamidine synthase activity
SynRS9909_01586	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynRS9909_01590	COG2211	Major facilitator Superfamily
SynRS9909_01593	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynRS9909_01595	COG0129	dihydroxy-acid dehydratase activity
SynRS9909_01599	COG0363	glucosamine-6-phosphate deaminase activity
SynRS9909_01600	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynRS9909_01601	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynRS9909_01602	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynRS9909_01603	COG1494	fructose-1,6-bisphosphatase
SynRS9909_01604	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynRS9909_01605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynRS9909_01610	COG1217	gtp-binding protein TYPA
SynRS9909_01611	COG0826	peptidase U32
SynRS9909_01613	COG0644	oxidoreductase
SynRS9909_01614	COG0751	glycine-tRNA ligase activity
SynRS9909_01615	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynRS9909_01616	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynRS9909_01617	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynRS9909_01619	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynRS9909_01620	COG0052	Belongs to the universal ribosomal protein uS2 family
SynRS9909_01621	COG1216	Glycosyl transferase, family 2
SynRS9909_01623	COG1136	(ABC) transporter
SynRS9909_01623	COG0577	efflux transmembrane transporter activity
SynRS9909_01627	COG0612	Peptidase, M16
SynRS9909_01631	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynRS9909_01632	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SynRS9909_01636	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynRS9909_01638	COG0174	glutamine synthetase
SynRS9909_01640	COG2226	methyltransferase
SynRS9909_01645	COG0515	serine threonine protein kinase
SynRS9909_01646	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynRS9909_01648	COG0628	permease
SynRS9909_01652	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynRS9909_01653	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynRS9909_01654	COG0022	dehydrogenase e1 component
SynRS9909_01657	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynRS9909_01658	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynRS9909_01659	COG0668	transmembrane transport
SynRS9909_01660	COG0792	nuclease activity
SynRS9909_01663	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynRS9909_01671	COG2801	Transposase and inactivated derivatives
SynRS9909_01673	COG0556	nucleotide-excision repair
SynRS9909_01675	COG0537	adenosine 5'-monophosphoramidase activity
SynRS9909_01680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynRS9909_01685	COG0798	PFAM Bile acid sodium symporter
SynRS9909_01687	COG0358	DNA primase activity
SynRS9909_01690	COG0632	four-way junction helicase activity
SynRS9909_01691	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynRS9909_01693	COG0587	DNA-directed DNA polymerase activity
SynRS9909_01694	COG0154	amidase activity
SynRS9909_01696	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynRS9909_01697	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynRS9909_01699	COG0505	Belongs to the CarA family
SynRS9909_01700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynRS9909_01701	COG1132	(ABC) transporter
SynRS9909_01703	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynRS9909_01707	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynRS9909_01708	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynRS9909_01710	COG2176	DNA-directed DNA polymerase activity
SynRS9909_01711	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynRS9909_01713	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynRS9909_01714	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynRS9909_01715	COG0142	geranyltranstransferase activity
SynRS9909_01716	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynRS9909_01719	COG2045	Belongs to the ComB family
SynRS9909_01720	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynRS9909_01721	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynRS9909_01722	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SynRS9909_01722	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynRS9909_01723	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynRS9909_01724	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynRS9909_01726	COG0297	glycogen (starch) synthase activity
SynRS9909_01727	COG1376	ErfK ybiS ycfS ynhG family protein
SynRS9909_01728	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynRS9909_01729	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynRS9909_01730	COG0681	Belongs to the peptidase S26 family
SynRS9909_01737	COG0450	alkyl hydroperoxide reductase
SynRS9909_01742	COG1840	ABC-type Fe3 transport system, periplasmic component
SynRS9909_01743	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SynRS9909_01746	COG2801	Transposase and inactivated derivatives
SynRS9909_01747	COG1528	Iron-storage protein
SynRS9909_01750	COG1121	(ABC) transporter
SynRS9909_01751	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynRS9909_01771	COG3275	phosphorelay sensor kinase activity
SynRS9909_01781	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynRS9909_01783	COG1121	(ABC) transporter
SynRS9909_01785	COG3659	wide pore channel activity
SynRS9909_01786	COG2010	Cytochrome c
SynRS9909_01788	COG1006	Multisubunit Na H antiporter MnhC subunit
SynRS9909_01789	COG0651	ATP synthesis coupled electron transport
SynRS9909_01797	COG0701	Predicted permease
SynRS9909_01804	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynRS9909_01807	COG0367	asparagine synthase
SynRS9909_01808	COG0540	Belongs to the ATCase OTCase family
SynRS9909_01813	COG1121	(ABC) transporter
SynRS9909_01818	COG0390	transport system, permease component
SynRS9909_01837	COG1064	alcohol dehydrogenase
SynRS9909_01841	COG3781	membrane
SynRS9909_01845	COG2226	methyltransferase
SynRS9909_01852	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynRS9909_01860	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SynRS9909_01867	COG0180	Tryptophanyl-tRNA synthetase
SynRS9909_01871	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynRS9909_01873	COG0837	glucose binding
SynRS9909_01874	COG0083	homoserine kinase activity
SynRS9909_01875	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9909_01876	COG0339	signal peptide processing
SynRS9909_01882	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SynRS9909_01883	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynRS9909_01891	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynRS9909_01892	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynRS9909_01894	COG3794	PFAM blue (type 1) copper domain protein
SynRS9909_01898	COG0542	response to heat
SynRS9909_01900	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynRS9909_01900	COG0140	phosphoribosyl-ATP diphosphatase activity
SynRS9909_01902	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynRS9909_01911	COG0159	tryptophan synthase activity
SynRS9909_01916	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynRS9909_01916	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynRS9909_01922	COG0251	oxidation-reduction process
SynRS9909_01925	COG0418	dihydroorotase activity
SynRS9909_01926	COG0659	secondary active sulfate transmembrane transporter activity
SynRS9909_01931	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynRS9909_01932	COG1845	cytochrome c oxidase, subunit III
SynRS9909_01938	COG0811	peptide transport
SynRS9909_01940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SynRS9909_01941	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynRS9909_01943	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynRS9909_01948	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynRS9909_01949	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynRS9909_01952	COG0456	acetyltransferase
SynRS9909_01953	COG0596	Alpha beta hydrolase
SynRS9909_01954	COG1132	(ABC) transporter
SynRS9909_01955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynRS9909_01956	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynRS9909_01957	COG3842	ATPase activity
SynRS9909_01958	COG0251	oxidation-reduction process
SynRS9909_01964	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9909_01965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynRS9909_01966	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynRS9909_01971	COG4451	ribulose bisphosphate carboxylase, small
SynRS9909_01972	COG1850	ribulose-bisphosphate carboxylase activity
SynRS9909_01973	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynRS9909_01974	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynRS9909_01975	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynRS9909_01978	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynRS9909_01979	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynRS9909_01980	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynRS9909_01985	COG0730	response to heat
SynRS9909_01986	COG0095	Lipoate-protein ligase
SynRS9909_01987	COG1994	Peptidase M50
SynRS9909_01987	COG0517	IMP dehydrogenase activity
SynRS9909_01988	COG0135	phosphoribosylanthranilate isomerase activity
SynRS9909_01990	COG0302	gtp cyclohydrolase
SynRS9909_01991	COG1028	Short-chain dehydrogenase reductase Sdr
SynRS9909_01992	COG0825	malonyl-CoA metabolic process
SynRS9909_01993	COG5322	oxidoreductase activity
SynRS9909_01994	COG3396	Phenylacetate-CoA oxygenase
SynRS9909_01996	COG0539	negative regulation of cytoplasmic translation
SynRS9909_01999	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynRS9909_02003	COG0028	Belongs to the TPP enzyme family
SynRS9909_02004	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynRS9909_02005	COG0582	viral genome integration into host DNA
SynRS9909_02006	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynRS9909_02009	COG0528	UMP kinase activity
SynRS9909_02010	COG0233	cytoplasmic translational termination
SynRS9909_02012	COG0415	Belongs to the DNA photolyase family
SynRS9909_02014	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynRS9909_02019	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SynRS9909_02020	COG0681	Belongs to the peptidase S26 family
SynRS9909_02024	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynRS9909_02026	COG0442	prolyl-tRNA aminoacylation
SynRS9909_02028	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynRS9909_02029	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynRS9909_02035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynRS9909_02037	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynRS9909_02038	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynRS9909_02041	COG2095	MarC family integral membrane protein
SynRS9909_02043	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynRS9909_02056	COG2267	carboxylic ester hydrolase activity
SynRS9909_02065	COG2801	Transposase and inactivated derivatives
SynRS9909_02075	COG2801	Transposase and inactivated derivatives
SynRS9909_02076	COG1970	mechanosensitive ion channel activity
SynRS9909_02105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynRS9909_02116	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynRS9909_02119	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynRS9909_02121	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynRS9909_02122	COG0523	cobalamin synthesis protein
SynRS9909_02124	COG1840	ABC-type Fe3 transport system, periplasmic component
SynRS9909_02128	COG2814	Major facilitator Superfamily
SynRS9909_02130	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynRS9909_02134	COG0708	Exodeoxyribonuclease III
SynRS9909_02135	COG0277	FAD linked oxidase domain protein
SynRS9909_02136	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynRS9909_02138	COG1666	GTP binding
SynRS9909_02140	COG0330	HflC and HflK could
SynRS9909_02143	COG0857	belongs to the CobB CobQ family
SynRS9909_02145	COG0300	oxidoreductase activity
SynRS9909_02145	COG3000	fatty acid hydroxylase
SynRS9909_02146	COG0024	Methionine aminopeptidase
SynRS9909_02148	COG0335	large ribosomal subunit rRNA binding
SynRS9909_02153	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynRS9909_02155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynRS9909_02157	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynRS9909_02158	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynRS9909_02161	COG0194	GDP metabolic process
SynRS9909_02162	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynRS9909_02163	COG0805	protein transport
SynRS9909_02165	COG0723	plastoquinol--plastocyanin reductase activity
SynRS9909_02166	COG3258	Cytochrome c
SynRS9909_02171	COG0248	Ppx GppA phosphatase
SynRS9909_02172	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynRS9909_02173	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynRS9909_02174	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynRS9909_02175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynRS9909_02177	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynRS9909_02178	COG1028	Short-chain dehydrogenase reductase Sdr
SynRS9909_02180	COG0459	protein refolding
SynRS9909_02182	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynRS9909_02186	COG0109	protoheme IX farnesyltransferase activity
SynRS9909_02190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynRS9909_02191	COG1845	cytochrome c oxidase, subunit III
SynRS9909_02198	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynRS9909_02201	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynRS9909_02202	COG1007	ATP synthesis coupled electron transport
SynRS9909_02203	COG1136	(ABC) transporter
SynRS9909_02204	COG0745	RESPONSE REGULATOR receiver
SynRS9909_02205	COG0739	heme binding
SynRS9909_02206	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynRS9909_02206	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynRS9909_02207	COG0436	Aminotransferase
SynRS9909_02208	COG3118	belongs to the thioredoxin family
SynRS9909_02209	COG1842	Phage shock protein A
SynRS9909_02211	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynRS9909_02213	COG0697	spore germination
SynRS9909_02214	COG0616	signal peptide processing
SynRS9909_02217	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynRS9909_02218	COG0594	ribonuclease P activity
SynRS9909_02220	COG0706	membrane insertase activity
SynRS9909_02222	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynRS9909_02224	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynRS9909_02225	COG0750	zinc metalloprotease
SynRS9909_02227	COG1185	polyribonucleotide nucleotidyltransferase activity
SynRS9909_02229	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynRS9909_02237	COG0776	regulation of translation
SynRS9909_02238	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynRS9909_02242	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SynRS9909_02245	COG2211	Major facilitator Superfamily
SynRS9909_02246	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynRS9909_02249	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynRS9909_02250	COG0284	orotidine-5'-phosphate decarboxylase activity
SynRS9909_02251	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynRS9909_02253	COG2197	response regulator
SynRS9909_02256	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynRS9909_02259	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynRS9909_02261	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynRS9909_02262	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynRS9909_02263	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynRS9909_02265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynRS9909_02267	COG0151	Belongs to the GarS family
SynRS9909_02268	COG5002	protein histidine kinase activity
SynRS9909_02269	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynRS9909_02270	COG4251	negative regulation of phosphorylation
SynRS9909_02272	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynRS9909_02273	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynRS9909_02275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynRS9909_02276	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynRS9909_02277	COG0217	transcriptional regulatory protein
SynRS9909_02278	COG0363	glucosamine-6-phosphate deaminase activity
SynRS9909_02279	COG2385	sporulation resulting in formation of a cellular spore
SynRS9909_02280	COG1234	tRNA 3'-trailer cleavage
SynRS9909_02281	COG2010	Cytochrome c
SynRS9909_02284	COG2264	protein methyltransferase activity
SynRS9909_02285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynRS9909_02289	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynRS9909_02296	COG0443	Heat shock 70 kDa protein
SynRS9909_02299	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynRS9909_02300	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynRS9909_02302	COG0459	protein refolding
SynRS9909_02303	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynRS9909_02304	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynRS9909_02305	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynRS9909_02309	COG0006	proline dipeptidase activity
SynRS9909_02310	COG1253	flavin adenine dinucleotide binding
SynRS9909_02311	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynRS9909_02312	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynRS9909_02313	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynRS9909_02313	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynRS9909_02315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynRS9909_02317	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynRS9909_02318	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynRS9909_02319	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynRS9909_02320	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynRS9909_02321	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynRS9909_02322	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynRS9909_02323	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynRS9909_02324	COG0356	it plays a direct role in the translocation of protons across the membrane
SynRS9909_02326	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynRS9909_02327	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynRS9909_02331	COG0772	Belongs to the SEDS family
SynRS9909_02333	COG1333	cytochrome c biogenesis protein
SynRS9909_02334	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynRS9909_02337	COG0347	Belongs to the P(II) protein family
SynRS9909_02340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynRS9909_02341	COG0114	fumarate hydratase activity
SynRS9909_02342	COG4581	dead DEAH box helicase
SynRS9909_02343	COG0385	Bile acid
SynRS9909_02344	COG0156	8-amino-7-oxononanoate synthase activity
SynRS9909_02347	COG4106	trans-aconitate 2-methyltransferase activity
SynRS9909_02347	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynRS9909_02351	COG0484	heat shock protein binding
SynRS9909_02352	COG0357	Ribosomal RNA small subunit methyltransferase G
SynRS9909_02358	COG2223	nitrite transmembrane transporter activity
SynRS9909_02359	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynRS9909_02361	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynRS9909_02362	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynRS9909_02363	COG0085	RNA polymerase activity
SynRS9909_02364	COG0084	hydrolase, TatD family'
SynRS9909_02365	COG0268	Binds directly to 16S ribosomal RNA
SynRS9909_02366	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynRS9909_02367	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynRS9909_02368	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynRS9909_02371	COG0668	transmembrane transport
SynRS9909_02374	COG0641	radical SAM
SynRS9909_02375	COG0779	Required for maturation of 30S ribosomal subunits
SynRS9909_02376	COG0195	Participates in both transcription termination and antitermination
SynRS9909_02378	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynRS9909_02389	COG2988	succinylglutamate desuccinylase activity
SynRS9909_02390	COG0435	Glutathione S-transferase
SynRS9909_02392	COG0488	(ABC) transporter
SynRS9909_02397	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynRS9909_02398	COG3842	ATPase activity
SynRS9909_02399	COG1193	negative regulation of DNA recombination
SynRS9909_02405	COG0113	porphobilinogen synthase activity
SynRS9909_02406	COG0484	heat shock protein binding
SynRS9909_02408	COG0659	secondary active sulfate transmembrane transporter activity
SynRS9909_02411	COG0116	Belongs to the methyltransferase superfamily
SynRS9909_02415	COG1196	nuclear chromosome segregation
SynRS9909_02417	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynRS9909_02420	COG0439	Biotin carboxylase
SynRS9909_02423	COG0515	serine threonine protein kinase
SynRS9909_02426	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynRS9909_02427	COG4178	(ABC) transporter
SynRS9909_02428	COG0537	adenosine 5'-monophosphoramidase activity
SynRS9909_02431	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynRS9909_02434	COG0242	peptide deformylase activity
SynRS9909_02436	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynRS9909_02438	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynRS9909_02439	COG0719	Fe-S assembly protein
SynRS9909_02440	COG0396	ATPase activity
SynRS9909_02441	COG0719	Fe-S assembly protein
SynRS9909_02442	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynRS9909_02443	COG1830	Aldolase
SynRS9909_02447	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynRS9909_02454	COG3744	PilT protein domain protein
SynRS9909_02463	COG2801	Transposase and inactivated derivatives
SynRS9909_02465	COG0457	Tetratricopeptide repeat
SynRS9909_02468	COG0033	Phosphoglucomutase
SynRS9909_02470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynRS9909_02472	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SynRS9909_02476	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynRS9909_02477	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynRS9909_02478	COG0175	sulfate reduction
SynRS9909_02479	COG1252	NADH dehydrogenase
SynRS9909_02480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynRS9909_02481	COG3273	potassium ion transport
SynRS9909_02481	COG0471	metal ion transport
SynRS9909_02482	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynRS9909_02483	COG0569	domain protein
SynRS9909_02484	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynRS9909_02490	COG0488	(ABC) transporter
SynRS9909_02492	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynRS9909_02495	COG1643	Atp-dependent helicase
SynRS9909_02496	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynRS9909_02498	COG1570	exodeoxyribonuclease VII activity
SynRS9909_02508	COG0483	inositol monophosphate 1-phosphatase activity
SynRS9909_02511	COG1968	undecaprenyl-diphosphatase activity
SynRS9909_02513	COG1555	photosystem II stabilization
SynRS9909_02514	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynRS9909_02515	COG4243	Vitamin k epoxide reductase
SynRS9909_02516	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynRS9909_02518	COG1032	radical SAM domain protein
SynRS9909_02528	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynRS9909_02529	COG1472	Belongs to the glycosyl hydrolase 3 family
SynRS9909_02530	COG0463	Glycosyl transferase, family 2
SynRS9909_02530	COG0457	Tetratricopeptide repeat
SynRS9909_02531	COG1587	Uroporphyrinogen-III synthase
SynRS9909_02534	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynRS9909_02535	COG0316	Belongs to the HesB IscA family
SynRS9909_02538	COG1090	epimerase
SynRS9909_02539	COG3263	regulation of cellular component size
SynRS9909_02542	COG0484	heat shock protein binding
SynRS9909_02543	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynRS9909_02544	COG3659	wide pore channel activity
SynRS9909_02545	COG3659	wide pore channel activity
SynRS9909_02546	COG3659	wide pore channel activity
SynRS9909_02552	COG1122	ATPase activity
SynRS9909_02555	COG0745	RESPONSE REGULATOR receiver
SynRS9909_02557	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynRS9909_02558	COG2217	Heavy metal translocating P-type atpase
SynRS9909_02559	COG3063	Type IV pilus biogenesis stability protein PilW
SynRS9909_02560	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynRS9909_02562	COG0416	fatty acid biosynthetic process
SynRS9909_02563	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynRS9909_02564	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynRS9909_02566	COG1214	PFAM Peptidase M22, glycoprotease
SynRS9909_02568	COG0617	tRNA 3'-terminal CCA addition
SynRS9909_02570	COG1562	ergosterol biosynthetic process
SynRS9909_02571	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynRS9909_02571	COG0493	'glutamate synthase
SynRS9909_02574	COG0583	DNA-binding transcription factor activity
SynRS9909_02576	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynRS9909_02577	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9909_02579	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynRS9909_02581	COG2197	response regulator
SynRS9909_02583	COG2954	triphosphatase activity
SynRS9909_02584	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynRS9909_02585	COG0713	ATP synthesis coupled electron transport
SynRS9909_02587	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynRS9909_02588	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynRS9909_02589	COG0372	Belongs to the citrate synthase family
SynRS9909_02593	COG1420	regulation of RNA biosynthetic process
SynRS9909_02594	COG0133	tryptophan synthase activity
SynRS9909_02595	COG0023	Translation Initiation Factor
SynRS9909_02596	COG0529	Catalyzes the synthesis of activated sulfate
SynRS9909_02597	COG0628	permease
SynRS9909_02598	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynRS9909_02600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynRS9909_02601	COG0564	pseudouridine synthase activity
SynRS9909_02602	COG0745	RESPONSE REGULATOR receiver
SynRS9909_02604	COG1104	cysteine desulfurase activity
SynRS9909_02609	COG0275	rRNA processing
SynRS9909_02610	COG0649	NAD binding
SynRS9909_02611	COG0824	Thioesterase
SynRS9909_02613	COG0318	PFAM AMP-dependent synthetase and ligase
SynRS9909_02614	COG4948	Mandelate Racemase Muconate Lactonizing
SynRS9909_02615	COG1575	Belongs to the MenA family. Type 1 subfamily
SynRS9909_02617	COG0189	ligase activity
SynRS9909_02618	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynRS9909_02619	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynRS9909_02621	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynRS9909_02622	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynRS9909_02625	COG0252	asparaginase activity
SynRS9909_02626	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynRS9909_02628	COG0018	arginyl-trna synthetase
SynRS9909_02633	COG0157	Belongs to the NadC ModD family
SynRS9909_02635	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynRS9909_02640	COG4106	trans-aconitate 2-methyltransferase activity
SynRS9909_02641	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynRS9909_02642	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynRS9909_02643	COG4172	Belongs to the ABC transporter superfamily
SynRS9909_02644	COG2197	response regulator
SynRS9909_02647	COG0564	pseudouridine synthase activity
SynRS9909_02648	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SynRS9909_02649	COG0589	response to stress
SynRS9909_02650	COG0126	phosphoglycerate kinase activity
SynRS9909_02653	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynRS9909_02660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynRS9909_02667	COG0167	dihydroorotate dehydrogenase activity
SynRS9909_02668	COG0328	RNA-DNA hybrid ribonuclease activity
SynRS9909_02670	COG0222	ribosome binding
SynRS9909_02671	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynRS9909_02672	COG0081	regulation of translation
SynRS9909_02673	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynRS9909_02674	COG0250	Participates in transcription elongation, termination and antitermination
SynRS9909_02675	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynRS9909_02676	COG0542	response to heat
SynRS9909_02677	COG0346	lactoylglutathione lyase activity
SynRS9909_02678	COG0148	phosphopyruvate hydratase activity
SynRS9909_02681	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynRS9909_02684	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynRS9909_02685	COG0237	dephospho-CoA kinase activity
SynRS9909_02690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynRS9909_02691	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynRS9909_02691	COG2022	thiamine diphosphate biosynthetic process
SynRS9909_02692	COG0105	UTP biosynthetic process
SynRS9909_02695	COG1166	arginine decarboxylase activity
SynRS9909_02704	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynRS9909_02707	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynRS9909_02710	COG0071	Belongs to the small heat shock protein (HSP20) family
SynRS9909_02712	COG0426	domain, Protein
SynRS9909_02712	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynRS9909_02713	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynRS9909_02713	COG0426	domain, Protein
SynRS9909_02714	COG1773	rubredoxin
SynRS9909_02716	COG1741	Belongs to the pirin family
SynRS9909_02720	COG0509	glycine decarboxylation via glycine cleavage system
SynRS9909_02721	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynRS9909_02725	COG0359	binds to the 23S rRNA
SynRS9909_02726	COG1372	Participates in initiation and elongation during chromosome replication
SynRS9909_02726	COG0305	Participates in initiation and elongation during chromosome replication
SynRS9909_02726	COG1372	Participates in initiation and elongation during chromosome replication
SynRS9909_02726	COG0305	Participates in initiation and elongation during chromosome replication
SynRS9909_02729	COG0445	tRNA wobble uridine modification
SynRS9909_02738	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynRS9909_02741	COG0398	Pfam SNARE associated Golgi protein
SynRS9909_02742	COG0668	transmembrane transport
SynRS9909_02744	COG0525	valine-tRNA ligase activity
SynRS9909_02746	COG3264	Mechanosensitive ion channel
SynRS9909_02746	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SynRS9909_02750	COG4221	oxidoreductase activity
SynRS9909_02754	COG3956	TIGRFAM MazG family protein
SynRS9909_02756	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynRS9909_02758	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynRS9909_02759	COG0010	Belongs to the arginase family
SynRS9909_02763	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynRS9909_02764	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynRS9909_02765	COG0783	Belongs to the Dps family
SynRS9909_02766	COG0504	CTP synthase activity
SynRS9909_02767	COG0602	queuosine metabolic process
SynRS9909_02769	COG4574	serine-type endopeptidase inhibitor activity
SynRS9909_02770	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynRS9909_02773	COG0531	amino acid
SynRS9909_02780	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynRS9909_02781	COG0830	nickel cation binding
SynRS9909_02782	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynRS9909_02783	COG0829	nickel cation binding
SynRS9909_02784	COG0831	urea catabolic process
SynRS9909_02785	COG0832	Belongs to the urease beta subunit family
SynRS9909_02786	COG0804	urea catabolic process
SynRS9909_02787	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynRS9909_02787	COG0519	Catalyzes the synthesis of GMP from XMP
SynRS9909_02792	COG0367	asparagine synthase
SynRS9909_02793	COG0540	Belongs to the ATCase OTCase family
SynRS9909_02797	COG2308	Evidence 4 Homologs of previously reported genes of
SynRS9909_02801	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynRS9909_02802	COG0746	molybdenum cofactor guanylyltransferase activity
SynRS9909_02804	COG2223	nitrite transmembrane transporter activity
SynRS9909_02805	COG0243	molybdopterin cofactor binding
SynRS9909_02809	COG0315	cyclic pyranopterin monophosphate synthase activity
SynRS9909_02810	COG0303	'Molybdopterin
SynRS9909_02813	COG0314	molybdopterin synthase activity
SynRS9909_02815	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynRS9909_02816	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynRS9909_02818	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynRS9909_02820	COG2116	formate transmembrane transporter activity
SynRS9909_02822	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynRS9909_02824	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynRS9909_02827	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynRS9909_02828	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynRS9909_02829	COG0170	dolichyl monophosphate biosynthetic process
SynRS9909_02830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynRS9909_02831	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynRS9909_02834	COG0788	formyltetrahydrofolate deformylase activity
SynRS9909_02836	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynRS9909_02838	COG0443	Heat shock 70 kDa protein
SynRS9909_02839	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynRS9909_02841	COG0360	Binds together with S18 to 16S ribosomal RNA
SynRS9909_02843	COG0137	argininosuccinate synthase activity
SynRS9909_02846	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynRS9909_02851	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynRS9909_02852	COG0438	transferase activity, transferring glycosyl groups
SynRS9909_02855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynRS9909_02856	COG0497	DNA recombination
SynRS9909_02857	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynRS9909_02859	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine