locus-tag	class	description
EVJ50_00020	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EVJ50_00030	COG0740	serine-type endopeptidase activity
EVJ50_00045	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EVJ50_00055	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EVJ50_00075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EVJ50_00080	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EVJ50_00080	COG2066	Belongs to the glutaminase family
EVJ50_00085	COG4948	Mandelate Racemase Muconate Lactonizing
EVJ50_00105	COG0402	S-adenosylhomocysteine deaminase activity
EVJ50_00125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EVJ50_00130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EVJ50_00135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EVJ50_00150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EVJ50_00155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EVJ50_00160	COG0134	indole-3-glycerol-phosphate synthase activity
EVJ50_00165	COG4251	negative regulation of phosphorylation
EVJ50_00170	COG0784	Response regulator, receiver
EVJ50_00200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EVJ50_00215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EVJ50_00220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EVJ50_00230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EVJ50_00235	COG1104	cysteine desulfurase activity
EVJ50_00240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EVJ50_00250	COG0706	membrane insertase activity
EVJ50_00260	COG0594	ribonuclease P activity
EVJ50_00280	COG0616	signal peptide processing
EVJ50_00285	COG0697	spore germination
EVJ50_00305	COG1842	Phage shock protein A
EVJ50_00310	COG0436	Aminotransferase
EVJ50_00315	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EVJ50_00315	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EVJ50_00320	COG0739	heme binding
EVJ50_00325	COG0745	RESPONSE REGULATOR receiver
EVJ50_00335	COG1136	(ABC) transporter
EVJ50_00340	COG1007	ATP synthesis coupled electron transport
EVJ50_00345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EVJ50_00360	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EVJ50_00390	COG1845	cytochrome c oxidase, subunit III
EVJ50_00395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EVJ50_00410	COG0109	protoheme IX farnesyltransferase activity
EVJ50_00430	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
EVJ50_00440	COG0459	protein refolding
EVJ50_00450	COG1028	Short-chain dehydrogenase reductase Sdr
EVJ50_00470	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EVJ50_00475	COG1619	proteins homologs of microcin C7 resistance protein MccF
EVJ50_00480	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EVJ50_00505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EVJ50_00510	COG0739	heme binding
EVJ50_00515	COG0723	plastoquinol--plastocyanin reductase activity
EVJ50_00525	COG0805	protein transport
EVJ50_00535	COG0194	GDP metabolic process
EVJ50_00550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EVJ50_00555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EVJ50_00565	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EVJ50_00570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EVJ50_00575	COG0012	GTP binding
EVJ50_00605	COG0460	homoserine dehydrogenase
EVJ50_00610	COG2166	iron-sulfur cluster assembly
EVJ50_00625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EVJ50_00630	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EVJ50_00635	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
EVJ50_00650	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EVJ50_00655	COG2010	Cytochrome c
EVJ50_00665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EVJ50_00675	COG3118	belongs to the thioredoxin family
EVJ50_00680	COG0516	GMP reductase activity
EVJ50_00690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EVJ50_00695	COG0644	oxidoreductase
EVJ50_00700	COG1543	Belongs to the glycosyl hydrolase 57 family
EVJ50_00705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EVJ50_00710	COG0395	ABC-type sugar transport system, permease component
EVJ50_00775	COG0531	amino acid
EVJ50_00790	COG2963	transposase activity
EVJ50_00830	COG0628	permease
EVJ50_00855	COG3264	Mechanosensitive ion channel
EVJ50_00855	COG1511	domain protein
EVJ50_00865	COG0641	radical SAM
EVJ50_00915	COG0011	TIGRFAM Protein of
EVJ50_00935	COG0366	Alpha amylase catalytic
EVJ50_00955	COG1480	7TM receptor with intracellular HD hydrolase
EVJ50_00965	COG0142	geranyltranstransferase activity
EVJ50_00985	COG1254	Belongs to the acylphosphatase family
EVJ50_00990	COG1797	cobyrinic acid a,c-diamide synthase activity
EVJ50_00995	COG3409	Peptidoglycan-binding domain 1 protein
EVJ50_00995	COG3429	Glucose-6-phosphate dehydrogenase subunit
EVJ50_01000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EVJ50_01005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EVJ50_01020	COG2205	protein histidine kinase activity
EVJ50_01030	COG0308	aminopeptidase N
EVJ50_01045	COG0776	regulation of translation
EVJ50_01070	COG1597	lipid kinase activity
EVJ50_01070	COG1803	Methylglyoxal synthase
EVJ50_01090	COG0628	permease
EVJ50_01095	COG1064	alcohol dehydrogenase
EVJ50_01110	COG0745	RESPONSE REGULATOR receiver
EVJ50_01110	COG3706	GGDEF domain
EVJ50_01120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EVJ50_01120	COG0574	Belongs to the PEP-utilizing enzyme family
EVJ50_01165	COG0702	epimerase
EVJ50_01175	COG0406	alpha-ribazole phosphatase activity
EVJ50_01180	COG0166	Belongs to the GPI family
EVJ50_01235	COG5001	Diguanylate cyclase
EVJ50_01235	COG3300	MHYT domain
EVJ50_01280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EVJ50_01305	COG3706	GGDEF domain
EVJ50_01305	COG0745	RESPONSE REGULATOR receiver
EVJ50_01320	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EVJ50_01330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EVJ50_01355	COG0347	Belongs to the P(II) protein family
EVJ50_01370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EVJ50_01390	COG2233	PERMEase
EVJ50_01395	COG3239	Fatty acid desaturase
EVJ50_01400	COG0724	RNA recognition motif
EVJ50_01470	COG0625	glutathione transferase activity
EVJ50_01495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EVJ50_01525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EVJ50_01540	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
EVJ50_01555	COG1187	pseudouridine synthase activity
EVJ50_01560	COG5002	protein histidine kinase activity
EVJ50_01565	COG0745	RESPONSE REGULATOR receiver
EVJ50_01570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EVJ50_01580	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EVJ50_01585	COG1982	Orn Lys Arg decarboxylase major
EVJ50_01610	COG0542	response to heat
EVJ50_01620	COG0019	diaminopimelate decarboxylase activity
EVJ50_01630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EVJ50_01635	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EVJ50_01645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EVJ50_01650	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EVJ50_01690	COG1316	TRANSCRIPTIONal
EVJ50_01695	COG0475	glutathione-regulated potassium exporter activity
EVJ50_01695	COG0589	response to stress
EVJ50_01700	COG1132	(ABC) transporter
EVJ50_01710	COG0724	RNA recognition motif
EVJ50_01725	COG0513	Belongs to the DEAD box helicase family
EVJ50_01735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EVJ50_01740	COG1074	ATP-dependent DNA helicase activity
EVJ50_01745	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EVJ50_01765	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EVJ50_01780	COG0271	Belongs to the BolA IbaG family
EVJ50_01785	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EVJ50_01795	COG0745	RESPONSE REGULATOR receiver
EVJ50_01820	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EVJ50_01845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EVJ50_01850	COG0640	Transcriptional regulator
EVJ50_01855	COG3706	GGDEF domain
EVJ50_01875	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EVJ50_01955	COG0500	methyltransferase
EVJ50_01985	COG0651	ATP synthesis coupled electron transport
EVJ50_01990	COG1006	Multisubunit Na H antiporter MnhC subunit
EVJ50_02010	COG3300	MHYT domain
EVJ50_02010	COG5001	Diguanylate cyclase
EVJ50_02030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EVJ50_02045	COG3437	response regulator, receiver
EVJ50_02070	COG2095	MarC family integral membrane protein
EVJ50_02155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EVJ50_02185	COG2801	Transposase and inactivated derivatives
EVJ50_02195	COG1301	dicarboxylic acid transport
EVJ50_02230	COG2801	Transposase and inactivated derivatives
EVJ50_02265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EVJ50_02270	COG2890	protein-(glutamine-N5) methyltransferase activity
EVJ50_02290	COG0318	PFAM AMP-dependent synthetase and ligase
EVJ50_02295	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EVJ50_02300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EVJ50_02330	COG0730	response to heat
EVJ50_02355	COG2133	pyrroloquinoline quinone binding
EVJ50_02385	COG0435	Glutathione S-transferase
EVJ50_02400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EVJ50_02425	COG0390	transport system, permease component
EVJ50_02430	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EVJ50_02460	COG2226	methyltransferase
EVJ50_02475	COG0295	cytidine deaminase activity
EVJ50_02480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EVJ50_02495	COG3781	membrane
EVJ50_02500	COG2124	cytochrome p450
EVJ50_02510	COG3706	GGDEF domain
EVJ50_02510	COG0745	RESPONSE REGULATOR receiver
EVJ50_02525	COG1131	(ABC) transporter
EVJ50_02540	COG0778	Nitroreductase
EVJ50_02550	COG2197	response regulator
EVJ50_02555	COG3706	GGDEF domain
EVJ50_02565	COG0745	RESPONSE REGULATOR receiver
EVJ50_02565	COG3706	GGDEF domain
EVJ50_02575	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EVJ50_02575	COG0284	orotidine-5'-phosphate decarboxylase activity
EVJ50_02580	COG0418	dihydroorotase activity
EVJ50_02585	COG0659	secondary active sulfate transmembrane transporter activity
EVJ50_02605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EVJ50_02610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EVJ50_02615	COG1845	cytochrome c oxidase, subunit III
EVJ50_02650	COG3604	Transcriptional regulator
EVJ50_02665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EVJ50_02670	COG0668	transmembrane transport
EVJ50_02690	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EVJ50_02695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EVJ50_02710	COG0456	acetyltransferase
EVJ50_02720	COG1132	(ABC) transporter
EVJ50_02725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EVJ50_02730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EVJ50_02735	COG3842	ATPase activity
EVJ50_02740	COG0251	oxidation-reduction process
EVJ50_02755	COG0464	growth
EVJ50_02770	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EVJ50_02775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EVJ50_02810	COG4451	ribulose bisphosphate carboxylase, small
EVJ50_02815	COG1850	ribulose-bisphosphate carboxylase activity
EVJ50_02825	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EVJ50_02845	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
EVJ50_02850	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
EVJ50_02855	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
EVJ50_02885	COG0730	response to heat
EVJ50_02890	COG0095	Lipoate-protein ligase
EVJ50_02895	COG0517	IMP dehydrogenase activity
EVJ50_02895	COG1994	Peptidase M50
EVJ50_02900	COG0135	phosphoribosylanthranilate isomerase activity
EVJ50_02905	COG0302	gtp cyclohydrolase
EVJ50_02910	COG1028	Short-chain dehydrogenase reductase Sdr
EVJ50_02915	COG0825	malonyl-CoA metabolic process
EVJ50_02935	COG0539	negative regulation of cytoplasmic translation
EVJ50_02950	COG0415	Belongs to the DNA photolyase family
EVJ50_02975	COG0028	Belongs to the TPP enzyme family
EVJ50_02985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EVJ50_03000	COG0528	UMP kinase activity
EVJ50_03005	COG0233	cytoplasmic translational termination
EVJ50_03020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EVJ50_03025	COG0768	penicillin binding
EVJ50_03040	COG0406	alpha-ribazole phosphatase activity
EVJ50_03045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EVJ50_03050	COG0681	Belongs to the peptidase S26 family
EVJ50_03070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EVJ50_03080	COG0442	prolyl-tRNA aminoacylation
EVJ50_03090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EVJ50_03095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EVJ50_03110	COG0629	single-stranded DNA binding
EVJ50_03125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EVJ50_03135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EVJ50_03140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EVJ50_03145	COG0181	hydroxymethylbilane synthase activity
EVJ50_03155	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EVJ50_03160	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EVJ50_03175	COG0432	Pfam Uncharacterised protein family UPF0047
EVJ50_03195	COG0542	response to heat
EVJ50_03205	COG2010	Cytochrome c
EVJ50_03210	COG3794	PFAM blue (type 1) copper domain protein
EVJ50_03225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EVJ50_03260	COG1940	carbohydrate kinase activity
EVJ50_03265	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EVJ50_03270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EVJ50_03280	COG5001	Diguanylate cyclase
EVJ50_03280	COG4251	negative regulation of phosphorylation
EVJ50_03280	COG3706	GGDEF domain
EVJ50_03280	COG2203	Gaf domain
EVJ50_03285	COG0339	signal peptide processing
EVJ50_03290	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EVJ50_03295	COG0083	homoserine kinase activity
EVJ50_03305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EVJ50_03315	COG0180	Tryptophanyl-tRNA synthetase
EVJ50_03340	COG1528	Iron-storage protein
EVJ50_03360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EVJ50_03370	COG1121	(ABC) transporter
EVJ50_03375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EVJ50_03380	COG3706	GGDEF domain
EVJ50_03385	COG0556	nucleotide-excision repair
EVJ50_03400	COG4574	serine-type endopeptidase inhibitor activity
EVJ50_03410	COG2010	Cytochrome c
EVJ50_03470	COG0681	Belongs to the peptidase S26 family
EVJ50_03475	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EVJ50_03485	COG1376	ErfK ybiS ycfS ynhG family protein
EVJ50_03500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EVJ50_03505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EVJ50_03515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EVJ50_03520	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EVJ50_03525	COG2045	Belongs to the ComB family
EVJ50_03530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EVJ50_03540	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EVJ50_03545	COG0142	geranyltranstransferase activity
EVJ50_03550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EVJ50_03555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EVJ50_03565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EVJ50_03580	COG1215	transferase activity, transferring glycosyl groups
EVJ50_03585	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EVJ50_03625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EVJ50_03635	COG1216	Glycosyl transferase, family 2
EVJ50_03640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EVJ50_03650	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EVJ50_03690	COG0385	Bile acid
EVJ50_03695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EVJ50_03705	COG1132	(ABC) transporter
EVJ50_03715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EVJ50_03720	COG0505	Belongs to the CarA family
EVJ50_03730	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
EVJ50_03735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EVJ50_03745	COG0154	amidase activity
EVJ50_03750	COG0587	DNA-directed DNA polymerase activity
EVJ50_03760	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EVJ50_03765	COG0632	four-way junction helicase activity
EVJ50_03820	COG0358	DNA primase activity
EVJ50_03840	COG1121	(ABC) transporter
EVJ50_03850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EVJ50_04000	COG1132	(ABC) transporter
EVJ50_04060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EVJ50_04065	COG0300	oxidoreductase activity
EVJ50_04135	COG2197	response regulator
EVJ50_04140	COG3979	chitinase
EVJ50_04150	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EVJ50_04160	COG0174	glutamine synthetase
EVJ50_04165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EVJ50_04180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EVJ50_04185	COG0385	Bile acid
EVJ50_04230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EVJ50_04235	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EVJ50_04245	COG0508	dehydrogenase complex catalyzes the overall conversion of
EVJ50_04245	COG0022	dehydrogenase e1 component
EVJ50_04250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EVJ50_04255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EVJ50_04265	COG0628	permease
EVJ50_04275	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EVJ50_04280	COG0515	serine threonine protein kinase
EVJ50_04310	COG2226	methyltransferase
EVJ50_04320	COG0174	glutamine synthetase
EVJ50_04330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EVJ50_04335	COG0590	tRNA wobble adenosine to inosine editing
EVJ50_04335	COG0037	tRNA processing
EVJ50_04350	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EVJ50_04355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EVJ50_04360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EVJ50_04375	COG0612	Peptidase, M16
EVJ50_04380	COG0612	Peptidase, M16
EVJ50_04400	COG1136	(ABC) transporter
EVJ50_04410	COG1216	Glycosyl transferase, family 2
EVJ50_04415	COG0052	Belongs to the universal ribosomal protein uS2 family
EVJ50_04420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EVJ50_04430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EVJ50_04435	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
EVJ50_04440	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EVJ50_04445	COG0751	glycine-tRNA ligase activity
EVJ50_04450	COG0644	oxidoreductase
EVJ50_04485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EVJ50_04490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EVJ50_04495	COG1494	fructose-1,6-bisphosphatase
EVJ50_04500	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EVJ50_04505	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EVJ50_04510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EVJ50_04515	COG0363	glucosamine-6-phosphate deaminase activity
EVJ50_04600	COG0129	dihydroxy-acid dehydratase activity
EVJ50_04610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EVJ50_04625	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EVJ50_04630	COG0047	phosphoribosylformylglycinamidine synthase activity
EVJ50_04635	COG1619	proteins homologs of microcin C7 resistance protein MccF
EVJ50_04640	COG0191	fructose-bisphosphate aldolase activity
EVJ50_04645	COG0673	inositol 2-dehydrogenase activity
EVJ50_04655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EVJ50_04660	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EVJ50_04670	COG3954	Phosphoribulokinase
EVJ50_04675	COG0473	3-isopropylmalate dehydrogenase activity
EVJ50_04680	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EVJ50_04685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EVJ50_04700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EVJ50_04715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EVJ50_04720	COG2197	response regulator
EVJ50_04730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EVJ50_04765	COG1201	RNA secondary structure unwinding
EVJ50_04770	COG1793	dna ligase
EVJ50_04775	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EVJ50_04775	COG1793	dna ligase
EVJ50_04810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EVJ50_04815	COG1175	transmembrane transport
EVJ50_04820	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EVJ50_04835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EVJ50_04845	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EVJ50_04855	COG0740	serine-type endopeptidase activity
EVJ50_04865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EVJ50_04875	COG0577	efflux transmembrane transporter activity
EVJ50_04875	COG1136	(ABC) transporter
EVJ50_04880	COG0469	pyruvate kinase activity
EVJ50_04900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EVJ50_04905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EVJ50_04935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EVJ50_04955	COG0395	ABC-type sugar transport system, permease component
EVJ50_04960	COG1175	transmembrane transport
EVJ50_04965	COG1653	transport
EVJ50_04970	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EVJ50_04975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EVJ50_04980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EVJ50_04985	COG0326	Molecular chaperone. Has ATPase activity
EVJ50_04990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EVJ50_05000	COG0483	inositol monophosphate 1-phosphatase activity
EVJ50_05015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EVJ50_05020	COG0581	inorganic phosphate transmembrane transporter activity
EVJ50_05025	COG0573	inorganic phosphate transmembrane transporter activity
EVJ50_05030	COG0443	Heat shock 70 kDa protein
EVJ50_05035	COG0484	heat shock protein binding
EVJ50_05040	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EVJ50_05045	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EVJ50_05050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EVJ50_05055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EVJ50_05055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EVJ50_05060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EVJ50_05065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EVJ50_05090	COG0495	leucyl-tRNA aminoacylation
EVJ50_05100	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EVJ50_05130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EVJ50_05135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EVJ50_05135	COG0426	domain, Protein
EVJ50_05140	COG0322	excinuclease ABC activity
EVJ50_05150	COG3046	protein related to deoxyribodipyrimidine photolyase
EVJ50_05175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EVJ50_05180	COG1410	methionine synthase
EVJ50_05180	COG0646	methionine synthase
EVJ50_05200	COG2385	sporulation resulting in formation of a cellular spore
EVJ50_05235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EVJ50_05240	COG0072	phenylalanine-tRNA ligase activity
EVJ50_05240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EVJ50_05245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EVJ50_05250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EVJ50_05255	COG0557	exoribonuclease II activity
EVJ50_05270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EVJ50_05305	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EVJ50_05310	COG0739	heme binding
EVJ50_05320	COG1119	ATPase activity
EVJ50_05330	COG0450	alkyl hydroperoxide reductase
EVJ50_05345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EVJ50_05350	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EVJ50_05370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EVJ50_05370	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EVJ50_05390	COG2119	membrane
EVJ50_05400	COG0557	exoribonuclease II activity
EVJ50_05405	COG0163	prenyltransferase activity
EVJ50_05420	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EVJ50_05425	COG0312	modulator of DNA gyrase
EVJ50_05435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EVJ50_05515	COG0463	Glycosyl transferase, family 2
EVJ50_05560	COG2801	Transposase and inactivated derivatives
EVJ50_05700	COG2801	Transposase and inactivated derivatives
EVJ50_05705	COG2801	Transposase and inactivated derivatives
EVJ50_05805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EVJ50_05820	COG0793	Belongs to the peptidase S41A family
EVJ50_05825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EVJ50_05830	COG1573	uracil-dna glycosylase
EVJ50_05840	COG0436	Aminotransferase
EVJ50_05845	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
EVJ50_05850	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EVJ50_05850	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EVJ50_05855	COG3639	organic phosphonate transmembrane transporter activity
EVJ50_05865	COG1191	sigma factor activity
EVJ50_05870	COG1836	PFAM Integral membrane protein DUF92
EVJ50_05880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EVJ50_05890	COG1136	(ABC) transporter
EVJ50_05895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EVJ50_05910	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EVJ50_05915	COG0659	secondary active sulfate transmembrane transporter activity
EVJ50_05980	COG2205	protein histidine kinase activity
EVJ50_06015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EVJ50_06025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EVJ50_06030	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EVJ50_06040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EVJ50_06045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EVJ50_06050	COG1429	ligase activity, forming nitrogen-metal bonds
EVJ50_06060	COG0745	RESPONSE REGULATOR receiver
EVJ50_06080	COG1132	(ABC) transporter
EVJ50_06095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EVJ50_06115	COG2801	Transposase and inactivated derivatives
EVJ50_06140	COG2274	protein secretion by the type I secretion system
EVJ50_06145	COG1115	amino acid carrier protein
EVJ50_06155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EVJ50_06165	COG0799	negative regulation of ribosome biogenesis
EVJ50_06205	COG0367	asparagine synthase
EVJ50_06220	COG0668	transmembrane transport
EVJ50_06250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EVJ50_06255	COG4597	amino acid ABC transporter
EVJ50_06260	COG0765	amino acid transport
EVJ50_06270	COG0076	glutamate decarboxylase activity
EVJ50_06305	COG0010	Belongs to the arginase family
EVJ50_06310	COG0375	protein maturation
EVJ50_06325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EVJ50_06330	COG1116	anion transmembrane transporter activity
EVJ50_06390	COG0668	transmembrane transport
EVJ50_06425	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EVJ50_06430	COG0482	sulfurtransferase activity
EVJ50_06435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EVJ50_06435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EVJ50_06440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EVJ50_06445	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EVJ50_06455	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EVJ50_06460	COG0228	four-way junction DNA binding
EVJ50_06465	COG1702	phosphate starvation-inducible protein PhoH
EVJ50_06470	COG0670	Belongs to the BI1 family
EVJ50_06480	COG1215	transferase activity, transferring glycosyl groups
EVJ50_06495	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EVJ50_06520	COG1691	(AIR) carboxylase
EVJ50_06540	COG0352	thiamine-phosphate diphosphorylase activity
EVJ50_06545	COG0196	riboflavin kinase activity
EVJ50_06555	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EVJ50_06560	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EVJ50_06565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EVJ50_06620	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EVJ50_06620	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EVJ50_06635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EVJ50_06640	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EVJ50_06645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EVJ50_06665	COG1492	cobalamin metabolic process
EVJ50_06675	COG0424	maF-like protein
EVJ50_06685	COG0438	transferase activity, transferring glycosyl groups
EVJ50_06690	COG0438	transferase activity, transferring glycosyl groups
EVJ50_06715	COG1116	anion transmembrane transporter activity
EVJ50_06735	COG3437	response regulator, receiver
EVJ50_06760	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EVJ50_06760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EVJ50_06785	COG0154	amidase activity
EVJ50_06835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EVJ50_06840	COG0440	acetolactate synthase activity
EVJ50_06870	COG2226	methyltransferase
EVJ50_06875	COG1187	pseudouridine synthase activity
EVJ50_06885	COG0492	ferredoxin-NADP+ reductase activity
EVJ50_06895	COG2084	Dehydrogenase
EVJ50_06900	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EVJ50_06910	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EVJ50_06925	COG3411	Ferredoxin
EVJ50_06930	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EVJ50_06935	COG0733	neurotransmitter:sodium symporter activity
EVJ50_06955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EVJ50_06955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EVJ50_06970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EVJ50_06990	COG0335	large ribosomal subunit rRNA binding
EVJ50_07000	COG0024	Methionine aminopeptidase
EVJ50_07005	COG0300	oxidoreductase activity
EVJ50_07005	COG3000	fatty acid hydroxylase
EVJ50_07015	COG0857	belongs to the CobB CobQ family
EVJ50_07030	COG0330	HflC and HflK could
EVJ50_07045	COG1666	GTP binding
EVJ50_07120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EVJ50_07125	COG0277	FAD linked oxidase domain protein
EVJ50_07140	COG5002	protein histidine kinase activity
EVJ50_07140	COG5001	Diguanylate cyclase
EVJ50_07140	COG3447	MASE1 domain protein
EVJ50_07180	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
EVJ50_07190	COG0735	belongs to the Fur family
EVJ50_07210	COG0523	cobalamin synthesis protein
EVJ50_07215	COG0140	phosphoribosyl-ATP diphosphatase activity
EVJ50_07215	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EVJ50_07230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EVJ50_07235	COG3339	Conserved Protein
EVJ50_07260	COG2010	Cytochrome c
EVJ50_07275	COG0159	tryptophan synthase activity
EVJ50_07320	COG0123	including yeast histone deacetylase and acetoin utilization protein
EVJ50_07350	COG2319	Wd-40 repeat
EVJ50_07375	COG2211	Major facilitator Superfamily
EVJ50_07380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EVJ50_07395	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EVJ50_07400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EVJ50_07405	COG1799	cell septum assembly
EVJ50_07410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EVJ50_07420	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EVJ50_07425	COG1160	GTP binding
EVJ50_07440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EVJ50_07450	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EVJ50_07460	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EVJ50_07480	COG0405	Gamma-glutamyltransferase
EVJ50_07495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EVJ50_07505	COG1388	LysM domain
EVJ50_07505	COG3942	CHAP domain
EVJ50_07510	COG0514	ATP-dependent DNA helicase (RecQ)
EVJ50_07525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EVJ50_07530	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EVJ50_07535	COG0235	Class ii aldolase
EVJ50_07540	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
EVJ50_07575	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EVJ50_07580	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EVJ50_07585	COG0793	Belongs to the peptidase S41A family
EVJ50_07590	COG1078	dGTPase activity
EVJ50_07595	COG0850	regulation of cytokinetic process
EVJ50_07600	COG2894	cell division
EVJ50_07605	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EVJ50_07620	COG0009	L-threonylcarbamoyladenylate synthase
EVJ50_07625	COG2890	protein-(glutamine-N5) methyltransferase activity
EVJ50_07640	COG0589	response to stress
EVJ50_07665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EVJ50_07670	COG0539	negative regulation of cytoplasmic translation
EVJ50_07680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EVJ50_07685	COG1070	Carbohydrate kinase
EVJ50_07695	COG1040	competence protein
EVJ50_07710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EVJ50_07720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EVJ50_07770	COG1413	lyase activity
EVJ50_07775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EVJ50_07785	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EVJ50_07845	COG0408	coproporphyrinogen oxidase activity
EVJ50_07850	COG0489	protein tyrosine kinase activity
EVJ50_07855	COG0772	Belongs to the SEDS family
EVJ50_07870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EVJ50_07875	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EVJ50_07895	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EVJ50_07900	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EVJ50_07905	COG1606	tRNA processing
EVJ50_07955	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EVJ50_07970	COG3854	ATPases associated with a variety of cellular activities
EVJ50_07985	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EVJ50_07990	COG0088	Forms part of the polypeptide exit tunnel
EVJ50_07995	COG0089	rRNA binding
EVJ50_08005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EVJ50_08010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EVJ50_08015	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EVJ50_08025	COG0255	Belongs to the universal ribosomal protein uL29 family
EVJ50_08030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EVJ50_08035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EVJ50_08040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EVJ50_08045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EVJ50_08050	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EVJ50_08055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EVJ50_08060	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EVJ50_08065	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EVJ50_08070	COG0200	Binds to the 23S rRNA
EVJ50_08075	COG0201	protein transport
EVJ50_08080	COG0563	adenylate kinase activity
EVJ50_08085	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EVJ50_08095	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EVJ50_08100	COG0202	RNA polymerase activity
EVJ50_08105	COG0203	ribosomal protein L17
EVJ50_08110	COG0101	tRNA pseudouridine synthase activity
EVJ50_08125	COG0254	rRNA binding
EVJ50_08130	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EVJ50_08140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EVJ50_08160	COG0463	Glycosyl transferase, family 2
EVJ50_08190	COG2885	chlorophyll binding
EVJ50_08205	COG1840	ABC-type Fe3 transport system, periplasmic component
EVJ50_08210	COG3128	pkhd-type hydroxylase
EVJ50_08220	COG3659	wide pore channel activity
EVJ50_08230	COG0310	cobalt ion transport
EVJ50_08235	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
EVJ50_08240	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EVJ50_08245	COG1122	ATPase activity
EVJ50_08260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EVJ50_08270	COG0069	glutamate synthase activity
EVJ50_08270	COG0070	glutamate synthase
EVJ50_08270	COG0067	glutamate synthase
EVJ50_08285	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EVJ50_08290	COG0049	tRNA binding
EVJ50_08300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EVJ50_08305	COG0051	transcription antitermination factor activity, RNA binding
EVJ50_08315	COG2226	methyltransferase
EVJ50_08330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EVJ50_08335	COG1530	ribonuclease E activity
EVJ50_08345	COG0436	Aminotransferase
EVJ50_08350	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EVJ50_08360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EVJ50_08365	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EVJ50_08375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EVJ50_08390	COG2046	Belongs to the sulfate adenylyltransferase family
EVJ50_08400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EVJ50_08405	COG3536	Protein conserved in bacteria
EVJ50_08425	COG0540	Belongs to the ATCase OTCase family
EVJ50_08430	COG2094	Belongs to the DNA glycosylase MPG family
EVJ50_08445	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EVJ50_08465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EVJ50_08490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EVJ50_08500	COG2971	BadF BadG BcrA BcrD
EVJ50_08505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EVJ50_08515	COG1196	nuclear chromosome segregation
EVJ50_08515	COG0741	lytic transglycosylase activity
EVJ50_08515	COG0739	heme binding
EVJ50_08525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EVJ50_08535	COG0717	Belongs to the dCTP deaminase family
EVJ50_08540	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EVJ50_08545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EVJ50_08550	COG4372	Transposase
EVJ50_08570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EVJ50_08605	COG0066	3-isopropylmalate dehydratase activity
EVJ50_08610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EVJ50_08615	COG1546	Belongs to the CinA family
EVJ50_08615	COG1058	Belongs to the CinA family
EVJ50_08620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EVJ50_08625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EVJ50_08650	COG0728	peptidoglycan biosynthetic process
EVJ50_08655	COG1489	DNA binding
EVJ50_08660	COG0004	ammonium transporteR
EVJ50_08665	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EVJ50_08680	COG0138	bifunctional purine biosynthesis protein purh
EVJ50_08700	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EVJ50_08705	COG0343	queuine tRNA-ribosyltransferase activity
EVJ50_08715	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EVJ50_08725	COG0673	inositol 2-dehydrogenase activity
EVJ50_08730	COG1253	flavin adenine dinucleotide binding
EVJ50_08750	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EVJ50_08755	COG0354	folic acid binding
EVJ50_08765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EVJ50_08775	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
EVJ50_08780	COG0131	Imidazoleglycerol-phosphate dehydratase
EVJ50_08785	COG2091	lysine biosynthetic process via aminoadipic acid
EVJ50_08790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EVJ50_08815	COG0415	Belongs to the DNA photolyase family
EVJ50_08820	COG0494	nUDIX hydrolase
EVJ50_08830	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
EVJ50_08830	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
EVJ50_08840	COG1127	ABC transporter
EVJ50_08845	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EVJ50_08850	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EVJ50_08855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EVJ50_08860	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EVJ50_08870	COG4447	cellulose binding
EVJ50_08905	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EVJ50_08950	COG3220	belongs to the UPF0276 family
EVJ50_08955	COG2132	Multicopper oxidase
EVJ50_08960	COG1725	Transcriptional regulator
EVJ50_08965	COG1045	serine acetyltransferase
EVJ50_08980	COG0653	protein targeting
EVJ50_09010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EVJ50_09040	COG1216	Glycosyl transferase, family 2
EVJ50_09060	COG1215	transferase activity, transferring glycosyl groups
EVJ50_09075	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EVJ50_09080	COG0124	histidyl-tRNA synthetase
EVJ50_09215	COG2801	Transposase and inactivated derivatives
EVJ50_09220	COG4584	PFAM Integrase catalytic
EVJ50_09280	COG2801	Transposase and inactivated derivatives
EVJ50_09325	COG0463	Glycosyl transferase, family 2
EVJ50_09345	COG2801	Transposase and inactivated derivatives
EVJ50_09405	COG0438	transferase activity, transferring glycosyl groups
EVJ50_09425	COG1215	transferase activity, transferring glycosyl groups
EVJ50_09485	COG1088	dTDP-glucose 4,6-dehydratase activity
EVJ50_09525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EVJ50_09530	COG0709	Synthesizes selenophosphate from selenide and ATP
EVJ50_09540	COG0617	tRNA 3'-terminal CCA addition
EVJ50_09545	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EVJ50_09545	COG0517	IMP dehydrogenase activity
EVJ50_09550	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EVJ50_09555	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EVJ50_09570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EVJ50_09600	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EVJ50_09625	COG0438	transferase activity, transferring glycosyl groups
EVJ50_09635	COG0438	transferase activity, transferring glycosyl groups
EVJ50_09640	COG1132	(ABC) transporter
EVJ50_09655	COG5398	heme oxygenase
EVJ50_09665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EVJ50_09670	COG0538	isocitrate dehydrogenase activity
EVJ50_09675	COG0247	lactate metabolic process
EVJ50_09680	COG3395	kinase activity
EVJ50_09685	COG0277	FAD linked oxidase domain protein
EVJ50_09710	COG0475	glutathione-regulated potassium exporter activity
EVJ50_09715	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
EVJ50_09720	COG0039	L-malate dehydrogenase activity
EVJ50_09725	COG0058	SHG alpha-glucan phosphorylase activity
EVJ50_09730	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EVJ50_09750	COG0306	phosphate transporter
EVJ50_09785	COG0571	ribonuclease III activity
EVJ50_09790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EVJ50_09800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EVJ50_09810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EVJ50_09815	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EVJ50_09820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EVJ50_09825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EVJ50_09830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EVJ50_09835	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EVJ50_09850	COG1473	amidohydrolase
EVJ50_09860	COG2255	four-way junction helicase activity
EVJ50_09865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EVJ50_09870	COG0515	serine threonine protein kinase
EVJ50_09880	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EVJ50_09900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EVJ50_09905	COG0745	RESPONSE REGULATOR receiver
EVJ50_09930	COG0629	single-stranded DNA binding
EVJ50_09935	COG0586	Pfam SNARE associated Golgi protein
EVJ50_09945	COG0802	atpase or kinase
EVJ50_10015	COG4251	negative regulation of phosphorylation
EVJ50_10070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EVJ50_10075	COG2239	Acts as a magnesium transporter
EVJ50_10080	COG0386	Belongs to the glutathione peroxidase family
EVJ50_10085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EVJ50_10090	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EVJ50_10100	COG0187	DNA topoisomerase II activity
EVJ50_10100	COG1372	Participates in initiation and elongation during chromosome replication
EVJ50_10105	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EVJ50_10110	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EVJ50_10135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EVJ50_10140	COG0556	nucleotide-excision repair
EVJ50_10155	COG0037	tRNA processing
EVJ50_10165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EVJ50_10170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EVJ50_10175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EVJ50_10180	COG0544	peptidyl-prolyl cis-trans isomerase activity
EVJ50_10185	COG0740	serine-type endopeptidase activity
EVJ50_10200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EVJ50_10205	COG1215	transferase activity, transferring glycosyl groups
EVJ50_10210	COG2385	sporulation resulting in formation of a cellular spore
EVJ50_10215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EVJ50_10220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EVJ50_10235	COG2022	thiamine diphosphate biosynthetic process
EVJ50_10245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EVJ50_10255	COG0768	penicillin binding
EVJ50_10330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EVJ50_10335	COG0511	ligase activity, forming carbon-carbon bonds
EVJ50_10340	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EVJ50_10345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EVJ50_10350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EVJ50_10355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EVJ50_10360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EVJ50_10365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EVJ50_10370	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EVJ50_10375	COG1162	GTPase activity
EVJ50_10385	COG0484	heat shock protein binding
EVJ50_10390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EVJ50_10410	COG2081	HI0933 family
EVJ50_10415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EVJ50_10420	COG0165	Argininosuccinate lyase
EVJ50_10425	COG2208	phosphoserine phosphatase activity
EVJ50_10430	COG0552	protein localization to endoplasmic reticulum
EVJ50_10435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EVJ50_10450	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EVJ50_10460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EVJ50_10465	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EVJ50_10470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EVJ50_10480	COG0592	DNA-directed DNA polymerase activity
EVJ50_10485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EVJ50_10495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EVJ50_10500	COG0497	DNA recombination
EVJ50_10505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EVJ50_10515	COG0438	transferase activity, transferring glycosyl groups
EVJ50_10520	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EVJ50_10535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EVJ50_10550	COG0137	argininosuccinate synthase activity
EVJ50_10560	COG0360	Binds together with S18 to 16S ribosomal RNA
EVJ50_10570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EVJ50_10575	COG0443	Heat shock 70 kDa protein
EVJ50_10585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EVJ50_10585	COG2022	thiamine diphosphate biosynthetic process
EVJ50_10595	COG0788	formyltetrahydrofolate deformylase activity
EVJ50_10610	COG1049	propionate catabolic process, 2-methylcitrate cycle
EVJ50_10615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EVJ50_10625	COG0170	dolichyl monophosphate biosynthetic process
EVJ50_10630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EVJ50_10635	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EVJ50_10640	COG0315	cyclic pyranopterin monophosphate synthase activity
EVJ50_10645	COG0303	'Molybdopterin
EVJ50_10655	COG0314	molybdopterin synthase activity
EVJ50_10665	COG0521	Mo-molybdopterin cofactor biosynthetic process
EVJ50_10670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EVJ50_10675	COG0746	molybdenum cofactor guanylyltransferase activity
EVJ50_10680	COG2223	nitrite transmembrane transporter activity
EVJ50_10685	COG0243	molybdopterin cofactor binding
EVJ50_10695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EVJ50_10700	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EVJ50_10710	COG2116	formate transmembrane transporter activity
EVJ50_10715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EVJ50_10735	COG1716	ATPase activity
EVJ50_10735	COG5001	Diguanylate cyclase
EVJ50_10740	COG0058	SHG alpha-glucan phosphorylase activity
EVJ50_10760	COG2308	Evidence 4 Homologs of previously reported genes of
EVJ50_10775	COG0832	Belongs to the urease beta subunit family
EVJ50_10780	COG0831	urea catabolic process
EVJ50_10785	COG0829	nickel cation binding
EVJ50_10790	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EVJ50_10795	COG0830	nickel cation binding
EVJ50_10800	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EVJ50_10820	COG0411	ABC transporter
EVJ50_10855	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EVJ50_10860	COG3706	GGDEF domain
EVJ50_10865	COG0602	queuosine metabolic process
EVJ50_10870	COG0504	CTP synthase activity
EVJ50_10875	COG0783	Belongs to the Dps family
EVJ50_10880	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EVJ50_10900	COG0010	Belongs to the arginase family
EVJ50_10905	COG3956	TIGRFAM MazG family protein
EVJ50_10915	COG3659	wide pore channel activity
EVJ50_10930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EVJ50_10975	COG4191	Histidine kinase
EVJ50_11000	COG5002	protein histidine kinase activity
EVJ50_11000	COG5001	Diguanylate cyclase
EVJ50_11000	COG3447	MASE1 domain protein
EVJ50_11005	COG3264	Mechanosensitive ion channel
EVJ50_11005	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EVJ50_11010	COG0668	transmembrane transport
EVJ50_11015	COG0583	DNA-binding transcription factor activity
EVJ50_11025	COG3239	Fatty acid desaturase
EVJ50_11030	COG0668	transmembrane transport
EVJ50_11035	COG0668	transmembrane transport
EVJ50_11050	COG1733	regulation of RNA biosynthetic process
EVJ50_11070	COG0668	transmembrane transport
EVJ50_11075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EVJ50_11100	COG0628	permease
EVJ50_11120	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EVJ50_11125	COG1028	Short-chain dehydrogenase reductase Sdr
EVJ50_11140	COG0604	alcohol dehydrogenase
EVJ50_11155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EVJ50_11160	COG3706	GGDEF domain
EVJ50_11160	COG0745	RESPONSE REGULATOR receiver
EVJ50_11165	COG0492	ferredoxin-NADP+ reductase activity
EVJ50_11190	COG3220	belongs to the UPF0276 family
EVJ50_11270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EVJ50_11270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EVJ50_11275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EVJ50_11295	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EVJ50_11310	COG2873	o-acetylhomoserine
EVJ50_11325	COG0525	valine-tRNA ligase activity
EVJ50_11335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EVJ50_11375	COG0445	tRNA wobble uridine modification
EVJ50_11385	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EVJ50_11390	COG1372	Participates in initiation and elongation during chromosome replication
EVJ50_11390	COG0305	Participates in initiation and elongation during chromosome replication
EVJ50_11390	COG1372	Participates in initiation and elongation during chromosome replication
EVJ50_11390	COG0305	Participates in initiation and elongation during chromosome replication
EVJ50_11395	COG0359	binds to the 23S rRNA
EVJ50_11415	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EVJ50_11420	COG0509	glycine decarboxylation via glycine cleavage system
EVJ50_11435	COG1741	Belongs to the pirin family
EVJ50_11450	COG1773	rubredoxin
EVJ50_11450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EVJ50_11455	COG0701	Predicted permease
EVJ50_11505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EVJ50_11505	COG0426	domain, Protein
EVJ50_11510	COG0426	domain, Protein
EVJ50_11510	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EVJ50_11530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EVJ50_11535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EVJ50_11575	COG0668	transmembrane transport
EVJ50_11600	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EVJ50_11605	COG1166	arginine decarboxylase activity
EVJ50_11620	COG0105	UTP biosynthetic process
EVJ50_11635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EVJ50_11635	COG2022	thiamine diphosphate biosynthetic process
EVJ50_11640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EVJ50_11655	COG0237	dephospho-CoA kinase activity
EVJ50_11665	COG4260	virion core protein, lumpy skin disease virus
EVJ50_11670	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EVJ50_11690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EVJ50_11695	COG0148	phosphopyruvate hydratase activity
EVJ50_11700	COG0346	lactoylglutathione lyase activity
EVJ50_11705	COG0542	response to heat
EVJ50_11710	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EVJ50_11715	COG0250	Participates in transcription elongation, termination and antitermination
EVJ50_11720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EVJ50_11725	COG0081	regulation of translation
EVJ50_11730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EVJ50_11735	COG0222	ribosome binding
EVJ50_11745	COG0328	RNA-DNA hybrid ribonuclease activity
EVJ50_11750	COG0167	dihydroorotate dehydrogenase activity
EVJ50_11775	COG1450	Type ii and iii secretion system protein
EVJ50_11800	COG0714	Associated with various cellular activities
EVJ50_11810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EVJ50_11830	COG0126	phosphoglycerate kinase activity
EVJ50_11835	COG0589	response to stress
EVJ50_11840	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EVJ50_11845	COG0564	pseudouridine synthase activity
EVJ50_11855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EVJ50_11870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EVJ50_11875	COG0157	Belongs to the NadC ModD family
EVJ50_11885	COG0018	arginyl-trna synthetase
EVJ50_11895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EVJ50_11910	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EVJ50_11915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EVJ50_11930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EVJ50_11935	COG0189	ligase activity
EVJ50_11945	COG1575	Belongs to the MenA family. Type 1 subfamily
EVJ50_11950	COG4948	Mandelate Racemase Muconate Lactonizing
EVJ50_11970	COG0824	Thioesterase
EVJ50_11995	COG0649	NAD binding
EVJ50_12000	COG0275	rRNA processing
EVJ50_12015	COG1104	cysteine desulfurase activity
EVJ50_12030	COG0564	pseudouridine synthase activity
EVJ50_12045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EVJ50_12050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EVJ50_12055	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EVJ50_12060	COG0628	permease
EVJ50_12065	COG0529	Catalyzes the synthesis of activated sulfate
EVJ50_12070	COG0023	Translation Initiation Factor
EVJ50_12075	COG0133	tryptophan synthase activity
EVJ50_12085	COG1420	regulation of RNA biosynthetic process
EVJ50_12100	COG2062	phosphohistidine phosphatase, SixA
EVJ50_12105	COG0372	Belongs to the citrate synthase family
EVJ50_12110	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EVJ50_12115	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EVJ50_12125	COG0713	ATP synthesis coupled electron transport
EVJ50_12130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EVJ50_12145	COG2197	response regulator
EVJ50_12155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EVJ50_12175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EVJ50_12185	COG0583	DNA-binding transcription factor activity
EVJ50_12200	COG0493	'glutamate synthase
EVJ50_12200	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
EVJ50_12205	COG1562	ergosterol biosynthetic process
EVJ50_12210	COG0724	RNA recognition motif
EVJ50_12215	COG0617	tRNA 3'-terminal CCA addition
EVJ50_12225	COG1214	PFAM Peptidase M22, glycoprotease
EVJ50_12235	COG0204	Acyl-transferase
EVJ50_12240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EVJ50_12245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EVJ50_12250	COG0416	fatty acid biosynthetic process
EVJ50_12260	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EVJ50_12265	COG3063	Type IV pilus biogenesis stability protein PilW
EVJ50_12270	COG2217	Heavy metal translocating P-type atpase
EVJ50_12275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EVJ50_12280	COG0470	DNA polymerase III
EVJ50_12285	COG0745	RESPONSE REGULATOR receiver
EVJ50_12295	COG1122	ATPase activity
EVJ50_12315	COG0463	Glycosyl transferase, family 2
EVJ50_12340	COG1215	transferase activity, transferring glycosyl groups
EVJ50_12350	COG3659	wide pore channel activity
EVJ50_12355	COG3659	wide pore channel activity
EVJ50_12370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EVJ50_12375	COG0484	heat shock protein binding
EVJ50_12390	COG3263	regulation of cellular component size
EVJ50_12395	COG1090	epimerase
EVJ50_12415	COG0316	Belongs to the HesB IscA family
EVJ50_12420	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
EVJ50_12430	COG1587	Uroporphyrinogen-III synthase
EVJ50_12435	COG0457	Tetratricopeptide repeat
EVJ50_12435	COG0463	Glycosyl transferase, family 2
EVJ50_12440	COG1472	Belongs to the glycosyl hydrolase 3 family
EVJ50_12445	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EVJ50_12470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EVJ50_12500	COG1032	radical SAM domain protein
EVJ50_12515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EVJ50_12520	COG4243	Vitamin k epoxide reductase
EVJ50_12530	COG1555	photosystem II stabilization
EVJ50_12540	COG1968	undecaprenyl-diphosphatase activity
EVJ50_12615	COG1570	exodeoxyribonuclease VII activity
EVJ50_12630	COG1643	Atp-dependent helicase
EVJ50_12645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EVJ50_12660	COG0488	(ABC) transporter
EVJ50_12685	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EVJ50_12690	COG0569	domain protein
EVJ50_12695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EVJ50_12700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EVJ50_12710	COG0175	sulfate reduction
EVJ50_12715	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EVJ50_12720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EVJ50_12740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EVJ50_12745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EVJ50_12755	COG0033	Phosphoglucomutase
EVJ50_12785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EVJ50_12810	COG0719	Fe-S assembly protein
EVJ50_12815	COG0396	ATPase activity
EVJ50_12820	COG0719	Fe-S assembly protein
EVJ50_12825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EVJ50_12835	COG0242	peptide deformylase activity
EVJ50_12850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EVJ50_12855	COG0606	chelatase, subunit chli
EVJ50_12860	COG0537	adenosine 5'-monophosphoramidase activity
EVJ50_12865	COG4178	(ABC) transporter
EVJ50_12885	COG0515	serine threonine protein kinase
EVJ50_12915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EVJ50_12925	COG1196	nuclear chromosome segregation
EVJ50_12940	COG0116	Belongs to the methyltransferase superfamily
EVJ50_12955	COG0523	cobalamin synthesis protein
EVJ50_12965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EVJ50_12985	COG0523	cobalamin synthesis protein
EVJ50_13000	COG3588	fructose-bisphosphate aldolase
EVJ50_13095	COG0318	PFAM AMP-dependent synthetase and ligase
EVJ50_13100	COG4243	Vitamin k epoxide reductase
EVJ50_13125	COG0667	Aldo Keto reductase
EVJ50_13150	COG0737	Belongs to the 5'-nucleotidase family
EVJ50_13175	COG1741	Belongs to the pirin family
EVJ50_13185	COG1733	regulation of RNA biosynthetic process
EVJ50_13205	COG2720	vancomycin resistance protein
EVJ50_13215	COG0045	succinate-CoA ligase (ADP-forming) activity
EVJ50_13215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EVJ50_13215	COG1042	CoA-binding domain protein
EVJ50_13220	COG0123	including yeast histone deacetylase and acetoin utilization protein
EVJ50_13235	COG1034	ATP synthesis coupled electron transport
EVJ50_13240	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
EVJ50_13245	COG3259	Nickel-dependent hydrogenase
EVJ50_13280	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EVJ50_13290	COG0298	carbon dioxide binding
EVJ50_13315	COG0484	heat shock protein binding
EVJ50_13320	COG0113	porphobilinogen synthase activity
EVJ50_13325	COG1193	negative regulation of DNA recombination
EVJ50_13330	COG3842	ATPase activity
EVJ50_13335	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EVJ50_13355	COG0435	Glutathione S-transferase
EVJ50_13360	COG2988	succinylglutamate desuccinylase activity
EVJ50_13405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EVJ50_13415	COG0195	Participates in both transcription termination and antitermination
EVJ50_13420	COG0779	Required for maturation of 30S ribosomal subunits
EVJ50_13430	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EVJ50_13435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EVJ50_13440	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EVJ50_13445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EVJ50_13450	COG0268	Binds directly to 16S ribosomal RNA
EVJ50_13455	COG0084	hydrolase, TatD family'
EVJ50_13465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EVJ50_13470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EVJ50_13480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EVJ50_13515	COG0357	Ribosomal RNA small subunit methyltransferase G
EVJ50_13520	COG0484	heat shock protein binding
EVJ50_13530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EVJ50_13540	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EVJ50_13545	COG2226	methyltransferase
EVJ50_13555	COG0156	8-amino-7-oxononanoate synthase activity
EVJ50_13560	COG4581	dead DEAH box helicase
EVJ50_13565	COG0114	fumarate hydratase activity
EVJ50_13570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EVJ50_13585	COG0347	Belongs to the P(II) protein family
EVJ50_13600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EVJ50_13605	COG1333	cytochrome c biogenesis protein
EVJ50_13615	COG0772	Belongs to the SEDS family
EVJ50_13635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EVJ50_13640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EVJ50_13650	COG0356	it plays a direct role in the translocation of protons across the membrane
EVJ50_13655	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EVJ50_13665	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EVJ50_13670	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EVJ50_13675	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EVJ50_13680	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EVJ50_13685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EVJ50_13695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EVJ50_13700	COG0659	secondary active sulfate transmembrane transporter activity
EVJ50_13705	COG0475	glutathione-regulated potassium exporter activity
EVJ50_13705	COG0589	response to stress
EVJ50_13710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EVJ50_13710	COG1017	nitric oxide dioxygenase activity
EVJ50_13720	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EVJ50_13720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EVJ50_13725	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EVJ50_13730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EVJ50_13735	COG1253	flavin adenine dinucleotide binding
EVJ50_13740	COG0006	proline dipeptidase activity
EVJ50_13755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EVJ50_13760	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EVJ50_13765	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EVJ50_13770	COG0459	protein refolding
EVJ50_13785	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EVJ50_13790	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EVJ50_13830	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EVJ50_13850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EVJ50_13855	COG2264	protein methyltransferase activity
EVJ50_13865	COG2010	Cytochrome c
EVJ50_13870	COG1234	tRNA 3'-trailer cleavage
EVJ50_13875	COG2385	sporulation resulting in formation of a cellular spore
EVJ50_13880	COG0363	glucosamine-6-phosphate deaminase activity
EVJ50_13885	COG0217	transcriptional regulatory protein
EVJ50_13890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EVJ50_13895	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EVJ50_13900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EVJ50_13905	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EVJ50_13910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EVJ50_13920	COG4251	negative regulation of phosphorylation
EVJ50_13925	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
EVJ50_13930	COG5002	protein histidine kinase activity
EVJ50_13935	COG0151	Belongs to the GarS family
EVJ50_13945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EVJ50_13955	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EVJ50_13960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EVJ50_13975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EVJ50_13995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EVJ50_14010	COG4566	intracellular signal transduction
EVJ50_14020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EVJ50_14025	COG0284	orotidine-5'-phosphate decarboxylase activity
EVJ50_14030	COG0438	transferase activity, transferring glycosyl groups
EVJ50_14040	COG1381	Involved in DNA repair and RecF pathway recombination
EVJ50_14045	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EVJ50_14050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EVJ50_14055	COG0321	lipoyl(octanoyl) transferase activity
EVJ50_14060	COG1022	Amp-dependent synthetase and ligase
EVJ50_14075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EVJ50_14080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EVJ50_14120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EVJ50_14150	COG1185	polyribonucleotide nucleotidyltransferase activity
EVJ50_14155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EVJ50_14160	COG0750	zinc metalloprotease
EVJ50_14165	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EVJ50_14190	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EVJ50_14195	COG0579	oxidoreductase
EVJ50_14200	COG0481	GTPase activity
EVJ50_14220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EVJ50_14225	COG3695	enzyme binding
EVJ50_14230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EVJ50_14230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EVJ50_14235	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EVJ50_14240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EVJ50_14250	COG0107	imidazoleglycerol-phosphate synthase activity
EVJ50_14260	COG2226	methyltransferase
EVJ50_14265	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EVJ50_14270	COG0752	glycyl-tRNA synthetase alpha subunit
EVJ50_14315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EVJ50_14320	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EVJ50_14330	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EVJ50_14335	COG0740	serine-type endopeptidase activity
EVJ50_14340	COG0740	serine-type endopeptidase activity
EVJ50_14345	COG4956	integral membrane protein (PIN domain superfamily)
EVJ50_14355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EVJ50_14365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EVJ50_14385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EVJ50_14390	COG2066	Belongs to the glutaminase family
EVJ50_14390	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EVJ50_14395	COG4948	Mandelate Racemase Muconate Lactonizing