locus-tag	class	description
SynSYN20_00001	COG0592	DNA-directed DNA polymerase activity
SynSYN20_00003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynSYN20_00004	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynSYN20_00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynSYN20_00007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynSYN20_00010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynSYN20_00011	COG0552	protein localization to endoplasmic reticulum
SynSYN20_00012	COG2208	phosphoserine phosphatase activity
SynSYN20_00013	COG0165	Argininosuccinate lyase
SynSYN20_00014	COG0724	RNA recognition motif
SynSYN20_00015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynSYN20_00016	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynSYN20_00017	COG2081	HI0933 family
SynSYN20_00018	COG1459	type II secretion system
SynSYN20_00020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynSYN20_00021	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynSYN20_00022	COG0484	heat shock protein binding
SynSYN20_00024	COG1162	GTPase activity
SynSYN20_00025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynSYN20_00026	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynSYN20_00027	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynSYN20_00029	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynSYN20_00030	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynSYN20_00031	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynSYN20_00032	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynSYN20_00033	COG0511	ligase activity, forming carbon-carbon bonds
SynSYN20_00034	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynSYN20_00051	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynSYN20_00051	COG0519	Catalyzes the synthesis of GMP from XMP
SynSYN20_00054	COG0768	penicillin binding
SynSYN20_00055	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynSYN20_00055	COG0438	transferase activity, transferring glycosyl groups
SynSYN20_00056	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynSYN20_00058	COG2022	thiamine diphosphate biosynthetic process
SynSYN20_00061	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynSYN20_00062	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynSYN20_00063	COG2385	sporulation resulting in formation of a cellular spore
SynSYN20_00064	COG1215	transferase activity, transferring glycosyl groups
SynSYN20_00065	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynSYN20_00067	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynSYN20_00068	COG0740	serine-type endopeptidase activity
SynSYN20_00069	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynSYN20_00071	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynSYN20_00072	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynSYN20_00073	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynSYN20_00075	COG0037	tRNA processing
SynSYN20_00078	COG0556	nucleotide-excision repair
SynSYN20_00082	COG2082	Precorrin-8x methylmutase
SynSYN20_00083	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynSYN20_00085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynSYN20_00090	COG0438	transferase activity, transferring glycosyl groups
SynSYN20_00091	COG0653	protein targeting
SynSYN20_00096	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynSYN20_00097	COG1088	dTDP-glucose 4,6-dehydratase activity
SynSYN20_00100	COG1216	Glycosyl transferase, family 2
SynSYN20_00100	COG0438	transferase activity, transferring glycosyl groups
SynSYN20_00105	COG1045	serine acetyltransferase
SynSYN20_00106	COG1725	Transcriptional regulator
SynSYN20_00108	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynSYN20_00109	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynSYN20_00110	COG1372	Participates in initiation and elongation during chromosome replication
SynSYN20_00110	COG0187	DNA topoisomerase II activity
SynSYN20_00112	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynSYN20_00113	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynSYN20_00114	COG0386	Belongs to the glutathione peroxidase family
SynSYN20_00115	COG2239	Acts as a magnesium transporter
SynSYN20_00116	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynSYN20_00117	COG0596	Alpha beta hydrolase
SynSYN20_00119	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynSYN20_00128	COG1819	glycosyl
SynSYN20_00134	COG2015	COG2015, Alkyl sulfatase and related hydrolases
SynSYN20_00137	COG2376	Dihydroxyacetone kinase
SynSYN20_00139	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynSYN20_00140	COG0242	peptide deformylase activity
SynSYN20_00141	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynSYN20_00143	COG0174	glutamine synthetase
SynSYN20_00145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SynSYN20_00146	COG0802	atpase or kinase
SynSYN20_00147	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynSYN20_00149	COG0586	Pfam SNARE associated Golgi protein
SynSYN20_00150	COG0629	single-stranded DNA binding
SynSYN20_00152	COG1792	Involved in formation and maintenance of cell shape
SynSYN20_00156	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynSYN20_00160	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynSYN20_00161	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynSYN20_00162	COG0515	serine threonine protein kinase
SynSYN20_00163	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynSYN20_00164	COG2255	four-way junction helicase activity
SynSYN20_00166	COG1473	amidohydrolase
SynSYN20_00169	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynSYN20_00177	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynSYN20_00178	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynSYN20_00180	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynSYN20_00181	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynSYN20_00182	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynSYN20_00183	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynSYN20_00184	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynSYN20_00193	COG0489	protein tyrosine kinase activity
SynSYN20_00197	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SynSYN20_00198	COG1132	(ABC) transporter
SynSYN20_00201	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynSYN20_00203	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SynSYN20_00207	COG0438	transferase activity, transferring glycosyl groups
SynSYN20_00210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SynSYN20_00210	COG2146	nitrite reductase [NAD(P)H] activity
SynSYN20_00213	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SynSYN20_00216	COG0297	glycogen (starch) synthase activity
SynSYN20_00225	COG2337	Toxic component of a toxin-antitoxin (TA) module
SynSYN20_00239	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynSYN20_00244	COG2337	Toxic component of a toxin-antitoxin (TA) module
SynSYN20_00253	COG0471	metal ion transport
SynSYN20_00253	COG3273	potassium ion transport
SynSYN20_00254	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynSYN20_00256	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynSYN20_00258	COG0571	ribonuclease III activity
SynSYN20_00262	COG1970	mechanosensitive ion channel activity
SynSYN20_00266	COG0058	SHG alpha-glucan phosphorylase activity
SynSYN20_00268	COG0475	glutathione-regulated potassium exporter activity
SynSYN20_00272	COG0277	FAD linked oxidase domain protein
SynSYN20_00274	COG0247	lactate metabolic process
SynSYN20_00275	COG0538	isocitrate dehydrogenase activity
SynSYN20_00276	COG0463	Glycosyl transferase, family 2
SynSYN20_00281	COG5398	heme oxygenase
SynSYN20_00286	COG1132	(ABC) transporter
SynSYN20_00287	COG0438	transferase activity, transferring glycosyl groups
SynSYN20_00295	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynSYN20_00297	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynSYN20_00299	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynSYN20_00300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SynSYN20_00300	COG0517	IMP dehydrogenase activity
SynSYN20_00302	COG0617	tRNA 3'-terminal CCA addition
SynSYN20_00304	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynSYN20_00305	COG0124	histidyl-tRNA synthetase
SynSYN20_00306	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynSYN20_00314	COG4447	cellulose binding
SynSYN20_00315	COG1773	rubredoxin
SynSYN20_00316	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynSYN20_00317	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynSYN20_00318	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynSYN20_00319	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynSYN20_00320	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SynSYN20_00321	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SynSYN20_00322	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynSYN20_00322	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynSYN20_00323	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SynSYN20_00324	COG0494	nUDIX hydrolase
SynSYN20_00325	COG0415	Belongs to the DNA photolyase family
SynSYN20_00331	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynSYN20_00332	COG3781	membrane
SynSYN20_00333	COG0131	Imidazoleglycerol-phosphate dehydratase
SynSYN20_00334	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynSYN20_00337	COG5002	protein histidine kinase activity
SynSYN20_00340	COG0745	RESPONSE REGULATOR receiver
SynSYN20_00341	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynSYN20_00346	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynSYN20_00347	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynSYN20_00349	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynSYN20_00350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynSYN20_00353	COG1253	flavin adenine dinucleotide binding
SynSYN20_00354	COG0673	inositol 2-dehydrogenase activity
SynSYN20_00358	COG0343	queuine tRNA-ribosyltransferase activity
SynSYN20_00359	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SynSYN20_00360	COG2205	protein histidine kinase activity
SynSYN20_00365	COG0138	bifunctional purine biosynthesis protein purh
SynSYN20_00368	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynSYN20_00369	COG0004	ammonium transporteR
SynSYN20_00370	COG1489	DNA binding
SynSYN20_00371	COG0728	peptidoglycan biosynthetic process
SynSYN20_00376	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynSYN20_00377	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynSYN20_00378	COG1058	Belongs to the CinA family
SynSYN20_00378	COG1546	Belongs to the CinA family
SynSYN20_00379	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynSYN20_00380	COG0066	3-isopropylmalate dehydratase activity
SynSYN20_00388	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynSYN20_00389	COG0193	aminoacyl-tRNA hydrolase activity
SynSYN20_00392	COG4372	Transposase
SynSYN20_00393	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynSYN20_00394	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynSYN20_00396	COG0717	Belongs to the dCTP deaminase family
SynSYN20_00398	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynSYN20_00402	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynSYN20_00405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynSYN20_00409	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynSYN20_00413	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynSYN20_00416	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynSYN20_00417	COG2094	Belongs to the DNA glycosylase MPG family
SynSYN20_00418	COG0540	Belongs to the ATCase OTCase family
SynSYN20_00428	COG3536	Protein conserved in bacteria
SynSYN20_00429	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynSYN20_00431	COG2046	Belongs to the sulfate adenylyltransferase family
SynSYN20_00431	COG0529	Catalyzes the synthesis of activated sulfate
SynSYN20_00432	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynSYN20_00435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynSYN20_00437	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynSYN20_00438	COG2226	methyltransferase
SynSYN20_00440	COG4176	ABC-type proline glycine betaine transport system permease component
SynSYN20_00441	COG2113	Glycine betaine
SynSYN20_00442	COG0463	Glycosyl transferase, family 2
SynSYN20_00443	COG0366	Alpha amylase catalytic
SynSYN20_00451	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynSYN20_00453	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynSYN20_00454	COG0436	Aminotransferase
SynSYN20_00455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynSYN20_00456	COG1530	ribonuclease E activity
SynSYN20_00457	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynSYN20_00459	COG1605	Chorismate mutase
SynSYN20_00459	COG0077	Prephenate dehydratase
SynSYN20_00460	COG2226	methyltransferase
SynSYN20_00461	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynSYN20_00462	COG0051	transcription antitermination factor activity, RNA binding
SynSYN20_00463	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynSYN20_00464	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynSYN20_00465	COG0049	tRNA binding
SynSYN20_00466	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynSYN20_00469	COG0069	glutamate synthase activity
SynSYN20_00469	COG0070	glutamate synthase
SynSYN20_00469	COG0067	glutamate synthase
SynSYN20_00471	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynSYN20_00475	COG2885	chlorophyll binding
SynSYN20_00476	COG2885	chlorophyll binding
SynSYN20_00479	COG3239	Fatty acid desaturase
SynSYN20_00485	COG0463	Glycosyl transferase, family 2
SynSYN20_00489	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynSYN20_00491	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynSYN20_00492	COG0254	rRNA binding
SynSYN20_00493	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynSYN20_00494	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynSYN20_00495	COG0101	tRNA pseudouridine synthase activity
SynSYN20_00496	COG0203	ribosomal protein L17
SynSYN20_00497	COG0202	RNA polymerase activity
SynSYN20_00498	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynSYN20_00499	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynSYN20_00500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynSYN20_00501	COG0563	adenylate kinase activity
SynSYN20_00502	COG0201	protein transport
SynSYN20_00503	COG0200	Binds to the 23S rRNA
SynSYN20_00504	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynSYN20_00505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynSYN20_00506	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynSYN20_00507	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynSYN20_00508	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynSYN20_00509	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynSYN20_00510	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynSYN20_00511	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynSYN20_00512	COG0255	Belongs to the universal ribosomal protein uL29 family
SynSYN20_00513	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynSYN20_00514	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynSYN20_00515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynSYN20_00516	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynSYN20_00517	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynSYN20_00518	COG0089	rRNA binding
SynSYN20_00519	COG0088	Forms part of the polypeptide exit tunnel
SynSYN20_00520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynSYN20_00524	COG3854	ATPases associated with a variety of cellular activities
SynSYN20_00527	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynSYN20_00531	COG0287	Prephenate dehydrogenase
SynSYN20_00532	COG1233	COG1233 Phytoene dehydrogenase and related
SynSYN20_00533	COG3001	Fructosamine kinase
SynSYN20_00537	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynSYN20_00538	COG1606	tRNA processing
SynSYN20_00539	COG0076	glutamate decarboxylase activity
SynSYN20_00540	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynSYN20_00541	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynSYN20_00544	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynSYN20_00545	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynSYN20_00546	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynSYN20_00549	COG0772	Belongs to the SEDS family
SynSYN20_00550	COG0489	protein tyrosine kinase activity
SynSYN20_00551	COG0408	coproporphyrinogen oxidase activity
SynSYN20_00560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynSYN20_00563	COG0656	L-ascorbic acid biosynthetic process
SynSYN20_00565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynSYN20_00567	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynSYN20_00568	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynSYN20_00568	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynSYN20_00569	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynSYN20_00595	COG0237	dephospho-CoA kinase activity
SynSYN20_00599	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynSYN20_00613	COG1070	Carbohydrate kinase
SynSYN20_00614	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynSYN20_00616	COG0539	negative regulation of cytoplasmic translation
SynSYN20_00617	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynSYN20_00621	COG0589	response to stress
SynSYN20_00626	COG2890	protein-(glutamine-N5) methyltransferase activity
SynSYN20_00627	COG0009	L-threonylcarbamoyladenylate synthase
SynSYN20_00631	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynSYN20_00632	COG2894	cell division
SynSYN20_00633	COG0850	regulation of cytokinetic process
SynSYN20_00634	COG1078	dGTPase activity
SynSYN20_00635	COG0793	Belongs to the peptidase S41A family
SynSYN20_00636	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynSYN20_00637	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynSYN20_00646	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynSYN20_00651	COG1012	belongs to the aldehyde dehydrogenase family
SynSYN20_00653	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynSYN20_00658	COG3852	Histidine kinase
SynSYN20_00659	COG4565	transcriptional regulatory protein
SynSYN20_00664	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynSYN20_00675	COG2197	response regulator
SynSYN20_00677	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynSYN20_00681	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynSYN20_00683	COG1376	ErfK ybiS ycfS ynhG family protein
SynSYN20_00684	COG1160	GTP binding
SynSYN20_00685	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynSYN20_00687	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynSYN20_00688	COG1799	cell septum assembly
SynSYN20_00689	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynSYN20_00690	COG0438	transferase activity, transferring glycosyl groups
SynSYN20_00692	COG1381	Involved in DNA repair and RecF pathway recombination
SynSYN20_00693	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SynSYN20_00694	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynSYN20_00695	COG0321	lipoyl(octanoyl) transferase activity
SynSYN20_00696	COG1022	Amp-dependent synthetase and ligase
SynSYN20_00698	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynSYN20_00699	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynSYN20_00724	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynSYN20_00726	COG0626	cystathionine gamma-synthase activity
SynSYN20_00733	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynSYN20_00736	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SynSYN20_00738	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynSYN20_00742	COG1104	cysteine desulfurase activity
SynSYN20_00748	COG0657	acetylesterase activity
SynSYN20_00751	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynSYN20_00752	COG0579	oxidoreductase
SynSYN20_00755	COG0481	GTPase activity
SynSYN20_00762	COG4969	Belongs to the N-Me-Phe pilin family
SynSYN20_00769	COG4968	Prepilin-type N-terminal cleavage methylation domain
SynSYN20_00771	COG5002	protein histidine kinase activity
SynSYN20_00772	COG0745	RESPONSE REGULATOR receiver
SynSYN20_00778	COG5002	protein histidine kinase activity
SynSYN20_00782	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynSYN20_00789	COG3695	enzyme binding
SynSYN20_00790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynSYN20_00790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynSYN20_00791	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynSYN20_00792	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynSYN20_00794	COG0107	imidazoleglycerol-phosphate synthase activity
SynSYN20_00796	COG2226	methyltransferase
SynSYN20_00799	COG0752	glycyl-tRNA synthetase alpha subunit
SynSYN20_00826	COG5002	protein histidine kinase activity
SynSYN20_00829	COG2132	Multicopper oxidase
SynSYN20_00861	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynSYN20_00862	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynSYN20_00863	COG0740	serine-type endopeptidase activity
SynSYN20_00864	COG0740	serine-type endopeptidase activity
SynSYN20_00865	COG4956	integral membrane protein (PIN domain superfamily)
SynSYN20_00866	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynSYN20_00867	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynSYN20_00868	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynSYN20_00871	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynSYN20_00872	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynSYN20_00873	COG4948	Mandelate Racemase Muconate Lactonizing
SynSYN20_00878	COG0277	FAD linked oxidase domain protein
SynSYN20_00883	COG0285	dihydrofolate synthase activity
SynSYN20_00884	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynSYN20_00886	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynSYN20_00889	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynSYN20_00890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynSYN20_00895	COG0134	indole-3-glycerol-phosphate synthase activity
SynSYN20_00901	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynSYN20_00902	COG0482	sulfurtransferase activity
SynSYN20_00903	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynSYN20_00903	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynSYN20_00905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynSYN20_00937	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynSYN20_00938	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynSYN20_00940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynSYN20_00941	COG0228	four-way junction DNA binding
SynSYN20_00942	COG1702	phosphate starvation-inducible protein PhoH
SynSYN20_00945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynSYN20_00947	COG0336	Belongs to the RNA methyltransferase TrmD family
SynSYN20_00954	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SynSYN20_00956	COG1691	(AIR) carboxylase
SynSYN20_00960	COG0352	thiamine-phosphate diphosphorylase activity
SynSYN20_00962	COG0196	riboflavin kinase activity
SynSYN20_00964	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynSYN20_00965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynSYN20_00971	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynSYN20_00974	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynSYN20_00975	COG0745	RESPONSE REGULATOR receiver
SynSYN20_00984	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynSYN20_00986	COG1803	Methylglyoxal synthase
SynSYN20_00986	COG1597	lipid kinase activity
SynSYN20_00997	COG0477	Major facilitator Superfamily
SynSYN20_01005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynSYN20_01005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynSYN20_01007	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynSYN20_01009	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynSYN20_01014	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynSYN20_01023	COG2814	Major facilitator Superfamily
SynSYN20_01033	COG0596	Alpha beta hydrolase
SynSYN20_01070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynSYN20_01078	COG0477	Major facilitator Superfamily
SynSYN20_01082	COG0432	Pfam Uncharacterised protein family UPF0047
SynSYN20_01087	COG1492	cobalamin metabolic process
SynSYN20_01089	COG0424	maF-like protein
SynSYN20_01094	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynSYN20_01095	COG0440	acetolactate synthase activity
SynSYN20_01096	COG2267	carboxylic ester hydrolase activity
SynSYN20_01101	COG2226	methyltransferase
SynSYN20_01104	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynSYN20_01105	COG0492	ferredoxin-NADP+ reductase activity
SynSYN20_01114	COG3411	Ferredoxin
SynSYN20_01115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynSYN20_01116	COG0733	neurotransmitter:sodium symporter activity
SynSYN20_01119	COG0215	cysteine-tRNA ligase activity
SynSYN20_01120	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynSYN20_01120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynSYN20_01121	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynSYN20_01122	COG0012	GTP binding
SynSYN20_01129	COG0601	transmembrane transport
SynSYN20_01130	COG4166	transmembrane transport
SynSYN20_01132	COG0460	homoserine dehydrogenase
SynSYN20_01133	COG2166	iron-sulfur cluster assembly
SynSYN20_01135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynSYN20_01154	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynSYN20_01155	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynSYN20_01158	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SynSYN20_01159	COG2010	Cytochrome c
SynSYN20_01161	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynSYN20_01162	COG3118	belongs to the thioredoxin family
SynSYN20_01163	COG0516	GMP reductase activity
SynSYN20_01165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynSYN20_01166	COG0644	oxidoreductase
SynSYN20_01167	COG1543	Belongs to the glycosyl hydrolase 57 family
SynSYN20_01168	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynSYN20_01169	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynSYN20_01170	COG0395	ABC-type sugar transport system, permease component
SynSYN20_01174	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynSYN20_01183	COG0564	pseudouridine synthase activity
SynSYN20_01184	COG1480	7TM receptor with intracellular HD hydrolase
SynSYN20_01185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynSYN20_01186	COG0142	geranyltranstransferase activity
SynSYN20_01197	COG0406	alpha-ribazole phosphatase activity
SynSYN20_01199	COG1254	Belongs to the acylphosphatase family
SynSYN20_01200	COG1797	cobyrinic acid a,c-diamide synthase activity
SynSYN20_01201	COG3409	Peptidoglycan-binding domain 1 protein
SynSYN20_01201	COG3429	Glucose-6-phosphate dehydrogenase subunit
SynSYN20_01202	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynSYN20_01209	COG2205	protein histidine kinase activity
SynSYN20_01212	COG0308	aminopeptidase N
SynSYN20_01214	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynSYN20_01219	COG1640	4-alpha-glucanotransferase
SynSYN20_01221	COG1187	pseudouridine synthase activity
SynSYN20_01222	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynSYN20_01224	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynSYN20_01227	COG1982	Orn Lys Arg decarboxylase major
SynSYN20_01228	COG0575	Belongs to the CDS family
SynSYN20_01230	COG2267	carboxylic ester hydrolase activity
SynSYN20_01231	COG0371	Dehydrogenase
SynSYN20_01232	COG0542	response to heat
SynSYN20_01233	COG0456	acetyltransferase
SynSYN20_01234	COG0019	diaminopimelate decarboxylase activity
SynSYN20_01235	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynSYN20_01236	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynSYN20_01237	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynSYN20_01238	COG1054	Belongs to the UPF0176 family
SynSYN20_01241	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynSYN20_01242	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynSYN20_01250	COG0589	response to stress
SynSYN20_01250	COG0475	glutathione-regulated potassium exporter activity
SynSYN20_01251	COG1132	(ABC) transporter
SynSYN20_01253	COG0724	RNA recognition motif
SynSYN20_01256	COG0513	Belongs to the DEAD box helicase family
SynSYN20_01257	COG0662	Cupin 2, conserved barrel domain protein
SynSYN20_01257	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynSYN20_01258	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynSYN20_01260	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynSYN20_01261	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SynSYN20_01290	COG2084	Dehydrogenase
SynSYN20_01332	COG2205	protein histidine kinase activity
SynSYN20_01333	COG0745	RESPONSE REGULATOR receiver
SynSYN20_01335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynSYN20_01337	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynSYN20_01343	COG0745	RESPONSE REGULATOR receiver
SynSYN20_01345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynSYN20_01346	COG0271	Belongs to the BolA IbaG family
SynSYN20_01349	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynSYN20_01360	COG0625	glutathione transferase activity
SynSYN20_01365	COG0735	belongs to the Fur family
SynSYN20_01367	COG1799	cell septum assembly
SynSYN20_01374	COG0420	3'-5' exonuclease activity
SynSYN20_01389	COG3659	wide pore channel activity
SynSYN20_01391	COG1126	abc transporter atp-binding protein
SynSYN20_01392	COG0765	amino acid transport
SynSYN20_01394	COG4597	amino acid ABC transporter
SynSYN20_01395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynSYN20_01397	COG0659	secondary active sulfate transmembrane transporter activity
SynSYN20_01404	COG3896	Chloramphenicol phosphotransferase-like protein
SynSYN20_01409	COG0799	negative regulation of ribosome biogenesis
SynSYN20_01412	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynSYN20_01414	COG1115	amino acid carrier protein
SynSYN20_01416	COG1132	(ABC) transporter
SynSYN20_01418	COG0149	triose-phosphate isomerase activity
SynSYN20_01419	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynSYN20_01421	COG1429	ligase activity, forming nitrogen-metal bonds
SynSYN20_01422	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynSYN20_01424	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynSYN20_01425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynSYN20_01427	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynSYN20_01460	COG0393	Putative heavy-metal-binding
SynSYN20_01463	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynSYN20_01468	COG4106	trans-aconitate 2-methyltransferase activity
SynSYN20_01469	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynSYN20_01472	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynSYN20_01473	COG1122	ATPase activity
SynSYN20_01475	COG0052	Belongs to the universal ribosomal protein uS2 family
SynSYN20_01476	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynSYN20_01478	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynSYN20_01479	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynSYN20_01480	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynSYN20_01481	COG0751	glycine-tRNA ligase activity
SynSYN20_01482	COG0644	oxidoreductase
SynSYN20_01487	COG1217	gtp-binding protein TYPA
SynSYN20_01492	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynSYN20_01500	COG0443	Heat shock 70 kDa protein
SynSYN20_01514	COG0861	Integral membrane protein TerC family
SynSYN20_01518	COG0513	Belongs to the DEAD box helicase family
SynSYN20_01524	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynSYN20_01526	COG0312	modulator of DNA gyrase
SynSYN20_01527	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynSYN20_01530	COG0163	prenyltransferase activity
SynSYN20_01531	COG0557	exoribonuclease II activity
SynSYN20_01533	COG2119	membrane
SynSYN20_01537	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynSYN20_01537	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynSYN20_01541	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynSYN20_01542	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynSYN20_01543	COG1615	UPF0182 protein
SynSYN20_01546	COG0450	alkyl hydroperoxide reductase
SynSYN20_01559	COG0358	DNA primase activity
SynSYN20_01562	COG0717	Belongs to the dCTP deaminase family
SynSYN20_01565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynSYN20_01566	COG0629	single-stranded DNA binding
SynSYN20_01575	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SynSYN20_01580	COG1191	sigma factor activity
SynSYN20_01585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SynSYN20_01686	COG0582	viral genome integration into host DNA
SynSYN20_01687	COG0739	heme binding
SynSYN20_01688	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynSYN20_01697	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynSYN20_01700	COG0557	exoribonuclease II activity
SynSYN20_01701	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynSYN20_01702	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynSYN20_01703	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynSYN20_01703	COG0072	phenylalanine-tRNA ligase activity
SynSYN20_01704	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynSYN20_01714	COG2385	sporulation resulting in formation of a cellular spore
SynSYN20_01720	COG1410	methionine synthase
SynSYN20_01720	COG0646	methionine synthase
SynSYN20_01721	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynSYN20_01724	COG0613	PHP domain protein
SynSYN20_01725	COG1981	membrane
SynSYN20_01726	COG3046	protein related to deoxyribodipyrimidine photolyase
SynSYN20_01728	COG0322	excinuclease ABC activity
SynSYN20_01729	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynSYN20_01734	COG1104	cysteine desulfurase activity
SynSYN20_01735	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynSYN20_01763	COG0495	leucyl-tRNA aminoacylation
SynSYN20_01764	COG0166	Belongs to the GPI family
SynSYN20_01769	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynSYN20_01770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynSYN20_01771	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynSYN20_01771	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynSYN20_01772	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynSYN20_01773	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynSYN20_01774	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynSYN20_01776	COG0484	heat shock protein binding
SynSYN20_01777	COG0443	Heat shock 70 kDa protein
SynSYN20_01778	COG0573	inorganic phosphate transmembrane transporter activity
SynSYN20_01779	COG0581	inorganic phosphate transmembrane transporter activity
SynSYN20_01780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynSYN20_01783	COG0483	inositol monophosphate 1-phosphatase activity
SynSYN20_01784	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynSYN20_01786	COG0326	Molecular chaperone. Has ATPase activity
SynSYN20_01787	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynSYN20_01788	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynSYN20_01789	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynSYN20_01790	COG1653	transport
SynSYN20_01793	COG3842	ATPase activity
SynSYN20_01798	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynSYN20_01799	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynSYN20_01803	COG0469	pyruvate kinase activity
SynSYN20_01804	COG1136	(ABC) transporter
SynSYN20_01804	COG0577	efflux transmembrane transporter activity
SynSYN20_01805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynSYN20_01806	COG0740	serine-type endopeptidase activity
SynSYN20_01812	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynSYN20_01813	COG2211	Major facilitator Superfamily
SynSYN20_01819	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynSYN20_01820	COG1175	transmembrane transport
SynSYN20_01821	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynSYN20_01829	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SynSYN20_01832	COG1793	dna ligase
SynSYN20_01833	COG1201	RNA secondary structure unwinding
SynSYN20_01847	COG0484	heat shock protein binding
SynSYN20_01850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynSYN20_01851	COG1121	(ABC) transporter
SynSYN20_01852	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynSYN20_01854	COG3659	wide pore channel activity
SynSYN20_01858	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynSYN20_01864	COG2226	methyltransferase
SynSYN20_01865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynSYN20_01869	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SynSYN20_01872	COG2124	cytochrome p450
SynSYN20_01879	COG2124	cytochrome p450
SynSYN20_01880	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SynSYN20_01881	COG1611	Belongs to the LOG family
SynSYN20_01909	COG0681	Belongs to the peptidase S26 family
SynSYN20_01910	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynSYN20_01912	COG1376	ErfK ybiS ycfS ynhG family protein
SynSYN20_01913	COG0297	glycogen (starch) synthase activity
SynSYN20_01915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynSYN20_01917	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynSYN20_01921	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynSYN20_01925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynSYN20_01927	COG3659	wide pore channel activity
SynSYN20_01929	COG3128	pkhd-type hydroxylase
SynSYN20_01931	COG1840	ABC-type Fe3 transport system, periplasmic component
SynSYN20_01932	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynSYN20_01933	COG2045	Belongs to the ComB family
SynSYN20_01935	COG0860	N-Acetylmuramoyl-L-alanine amidase
SynSYN20_01936	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynSYN20_01937	COG0142	geranyltranstransferase activity
SynSYN20_01938	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynSYN20_01939	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynSYN20_01942	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynSYN20_01943	COG2176	DNA-directed DNA polymerase activity
SynSYN20_01948	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynSYN20_01950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynSYN20_01951	COG0745	RESPONSE REGULATOR receiver
SynSYN20_01952	COG3659	wide pore channel activity
SynSYN20_01955	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynSYN20_01956	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SynSYN20_01960	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynSYN20_01963	COG0174	glutamine synthetase
SynSYN20_01976	COG2226	methyltransferase
SynSYN20_01981	COG0515	serine threonine protein kinase
SynSYN20_01982	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynSYN20_01984	COG0628	permease
SynSYN20_01986	COG0426	domain, Protein
SynSYN20_01986	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynSYN20_01988	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynSYN20_01989	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynSYN20_01990	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynSYN20_01990	COG0022	dehydrogenase e1 component
SynSYN20_01993	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynSYN20_01994	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynSYN20_01995	COG0572	uridine kinase
SynSYN20_02000	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynSYN20_02006	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynSYN20_02009	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynSYN20_02016	COG0358	DNA primase activity
SynSYN20_02036	COG0632	four-way junction helicase activity
SynSYN20_02037	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynSYN20_02039	COG0587	DNA-directed DNA polymerase activity
SynSYN20_02040	COG0154	amidase activity
SynSYN20_02042	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynSYN20_02043	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynSYN20_02044	COG1366	Belongs to the anti-sigma-factor antagonist family
SynSYN20_02045	COG0505	Belongs to the CarA family
SynSYN20_02046	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynSYN20_02047	COG1132	(ABC) transporter
SynSYN20_02049	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynSYN20_02059	COG0612	Peptidase, M16
SynSYN20_02063	COG1136	(ABC) transporter
SynSYN20_02065	COG1216	Glycosyl transferase, family 2
SynSYN20_02068	COG1836	PFAM Integral membrane protein DUF92
SynSYN20_02069	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynSYN20_02072	COG3639	organic phosphonate transmembrane transporter activity
SynSYN20_02073	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynSYN20_02073	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynSYN20_02074	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynSYN20_02075	COG0436	Aminotransferase
SynSYN20_02077	COG1573	uracil-dna glycosylase
SynSYN20_02078	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynSYN20_02079	COG0793	Belongs to the peptidase S41A family
SynSYN20_02083	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynSYN20_02089	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynSYN20_02090	COG1494	fructose-1,6-bisphosphatase
SynSYN20_02091	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynSYN20_02093	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynSYN20_02094	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynSYN20_02095	COG0363	glucosamine-6-phosphate deaminase activity
SynSYN20_02101	COG0129	dihydroxy-acid dehydratase activity
SynSYN20_02103	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynSYN20_02109	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynSYN20_02110	COG0047	phosphoribosylformylglycinamidine synthase activity
SynSYN20_02111	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynSYN20_02112	COG0191	fructose-bisphosphate aldolase activity
SynSYN20_02113	COG3588	fructose-bisphosphate aldolase
SynSYN20_02114	COG0673	inositol 2-dehydrogenase activity
SynSYN20_02116	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynSYN20_02117	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynSYN20_02119	COG3954	Phosphoribulokinase
SynSYN20_02120	COG0473	3-isopropylmalate dehydrogenase activity
SynSYN20_02122	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynSYN20_02123	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynSYN20_02126	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynSYN20_02129	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynSYN20_02130	COG2197	response regulator
SynSYN20_02132	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynSYN20_02134	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SynSYN20_02135	COG0517	IMP dehydrogenase activity
SynSYN20_02137	COG1376	ErfK ybiS ycfS ynhG family protein
SynSYN20_02143	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynSYN20_02154	COG2010	Cytochrome c
SynSYN20_02159	COG0803	Belongs to the bacterial solute-binding protein 9 family
SynSYN20_02161	COG1121	(ABC) transporter
SynSYN20_02164	COG0701	Predicted permease
SynSYN20_02165	COG2010	Cytochrome c
SynSYN20_02169	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynSYN20_02170	COG1121	(ABC) transporter
SynSYN20_02185	COG2032	superoxide dismutase activity
SynSYN20_02226	COG0300	oxidoreductase activity
SynSYN20_02231	COG0730	response to heat
SynSYN20_02237	COG2197	response regulator
SynSYN20_02261	COG1064	alcohol dehydrogenase
SynSYN20_02268	COG3781	membrane
SynSYN20_02284	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynSYN20_02285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynSYN20_02290	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SynSYN20_02292	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynSYN20_02292	COG0284	orotidine-5'-phosphate decarboxylase activity
SynSYN20_02298	COG0180	Tryptophanyl-tRNA synthetase
SynSYN20_02302	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynSYN20_02304	COG0837	glucose binding
SynSYN20_02305	COG0083	homoserine kinase activity
SynSYN20_02306	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynSYN20_02307	COG0339	signal peptide processing
SynSYN20_02309	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SynSYN20_02310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynSYN20_02318	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynSYN20_02319	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynSYN20_02321	COG3794	PFAM blue (type 1) copper domain protein
SynSYN20_02329	COG0542	response to heat
SynSYN20_02332	COG1566	PFAM secretion protein HlyD family protein
SynSYN20_02334	COG0140	phosphoribosyl-ATP diphosphatase activity
SynSYN20_02334	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynSYN20_02337	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynSYN20_02344	COG2010	Cytochrome c
SynSYN20_02346	COG0159	tryptophan synthase activity
SynSYN20_02350	COG0418	dihydroorotase activity
SynSYN20_02351	COG0659	secondary active sulfate transmembrane transporter activity
SynSYN20_02356	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynSYN20_02357	COG1845	cytochrome c oxidase, subunit III
SynSYN20_02359	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynSYN20_02361	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynSYN20_02362	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynSYN20_02365	COG0456	acetyltransferase
SynSYN20_02367	COG1132	(ABC) transporter
SynSYN20_02368	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynSYN20_02369	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynSYN20_02370	COG3842	ATPase activity
SynSYN20_02371	COG0251	oxidation-reduction process
SynSYN20_02377	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynSYN20_02378	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynSYN20_02379	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynSYN20_02384	COG4451	ribulose bisphosphate carboxylase, small
SynSYN20_02385	COG1850	ribulose-bisphosphate carboxylase activity
SynSYN20_02386	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynSYN20_02388	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynSYN20_02389	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SynSYN20_02392	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynSYN20_02393	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynSYN20_02394	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynSYN20_02400	COG0730	response to heat
SynSYN20_02401	COG0095	Lipoate-protein ligase
SynSYN20_02402	COG1994	Peptidase M50
SynSYN20_02402	COG0517	IMP dehydrogenase activity
SynSYN20_02403	COG0135	phosphoribosylanthranilate isomerase activity
SynSYN20_02405	COG0302	gtp cyclohydrolase
SynSYN20_02407	COG0825	malonyl-CoA metabolic process
SynSYN20_02408	COG5322	oxidoreductase activity
SynSYN20_02409	COG3396	Phenylacetate-CoA oxygenase
SynSYN20_02412	COG0539	negative regulation of cytoplasmic translation
SynSYN20_02416	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynSYN20_02421	COG0028	Belongs to the TPP enzyme family
SynSYN20_02422	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynSYN20_02423	COG0582	viral genome integration into host DNA
SynSYN20_02424	COG2226	methyltransferase
SynSYN20_02426	COG0528	UMP kinase activity
SynSYN20_02427	COG0233	cytoplasmic translational termination
SynSYN20_02428	COG0644	oxidoreductase
SynSYN20_02429	COG0415	Belongs to the DNA photolyase family
SynSYN20_02430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynSYN20_02431	COG0768	penicillin binding
SynSYN20_02436	COG0681	Belongs to the peptidase S26 family
SynSYN20_02440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynSYN20_02444	COG0442	prolyl-tRNA aminoacylation
SynSYN20_02446	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynSYN20_02448	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynSYN20_02452	COG0629	single-stranded DNA binding
SynSYN20_02455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynSYN20_02457	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynSYN20_02460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynSYN20_02463	COG0181	hydroxymethylbilane synthase activity
SynSYN20_02466	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynSYN20_02467	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynSYN20_02471	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynSYN20_02472	COG0523	cobalamin synthesis protein
SynSYN20_02476	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynSYN20_02500	COG0708	Exodeoxyribonuclease III
SynSYN20_02501	COG0277	FAD linked oxidase domain protein
SynSYN20_02503	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynSYN20_02506	COG1666	GTP binding
SynSYN20_02533	COG5505	Protein of unknown function (DUF819)
SynSYN20_02539	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynSYN20_02548	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SynSYN20_02584	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynSYN20_02586	COG1185	polyribonucleotide nucleotidyltransferase activity
SynSYN20_02588	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynSYN20_02589	COG0750	zinc metalloprotease
SynSYN20_02590	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynSYN20_02594	COG0706	membrane insertase activity
SynSYN20_02597	COG0594	ribonuclease P activity
SynSYN20_02599	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynSYN20_02602	COG0616	signal peptide processing
SynSYN20_02604	COG0697	spore germination
SynSYN20_02605	COG0438	transferase activity, transferring glycosyl groups
SynSYN20_02608	COG1842	Phage shock protein A
SynSYN20_02609	COG3118	belongs to the thioredoxin family
SynSYN20_02610	COG0436	Aminotransferase
SynSYN20_02611	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynSYN20_02611	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynSYN20_02612	COG0739	heme binding
SynSYN20_02613	COG0745	RESPONSE REGULATOR receiver
SynSYN20_02614	COG1136	(ABC) transporter
SynSYN20_02614	COG0577	efflux transmembrane transporter activity
SynSYN20_02615	COG1007	ATP synthesis coupled electron transport
SynSYN20_02616	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynSYN20_02619	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynSYN20_02626	COG1845	cytochrome c oxidase, subunit III
SynSYN20_02627	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynSYN20_02629	COG1612	heme a metabolic process
SynSYN20_02630	COG0109	protoheme IX farnesyltransferase activity
SynSYN20_02634	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynSYN20_02636	COG0459	protein refolding
SynSYN20_02638	COG1028	Short-chain dehydrogenase reductase Sdr
SynSYN20_02639	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynSYN20_02641	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynSYN20_02642	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynSYN20_02643	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynSYN20_02644	COG0248	Ppx GppA phosphatase
SynSYN20_02649	COG0739	heme binding
SynSYN20_02650	COG0723	plastoquinol--plastocyanin reductase activity
SynSYN20_02652	COG0805	protein transport
SynSYN20_02653	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SynSYN20_02654	COG0194	GDP metabolic process
SynSYN20_02657	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynSYN20_02658	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynSYN20_02663	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynSYN20_02668	COG0335	large ribosomal subunit rRNA binding
SynSYN20_02670	COG0024	Methionine aminopeptidase
SynSYN20_02671	COG0300	oxidoreductase activity
SynSYN20_02671	COG3000	fatty acid hydroxylase
SynSYN20_02673	COG0857	belongs to the CobB CobQ family
SynSYN20_02692	COG0776	regulation of translation
SynSYN20_02696	COG2211	Major facilitator Superfamily
SynSYN20_02697	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynSYN20_02701	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynSYN20_02702	COG0284	orotidine-5'-phosphate decarboxylase activity
SynSYN20_02703	COG3386	PFAM SMP-30 Gluconolaconase
SynSYN20_02705	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynSYN20_02707	COG2197	response regulator
SynSYN20_02710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynSYN20_02713	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynSYN20_02715	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynSYN20_02716	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynSYN20_02717	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynSYN20_02719	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynSYN20_02722	COG0151	Belongs to the GarS family
SynSYN20_02723	COG5002	protein histidine kinase activity
SynSYN20_02724	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynSYN20_02725	COG4251	negative regulation of phosphorylation
SynSYN20_02727	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynSYN20_02728	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynSYN20_02729	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynSYN20_02730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynSYN20_02731	COG0217	transcriptional regulatory protein
SynSYN20_02744	COG2223	nitrite transmembrane transporter activity
SynSYN20_02750	COG0363	glucosamine-6-phosphate deaminase activity
SynSYN20_02751	COG2385	sporulation resulting in formation of a cellular spore
SynSYN20_02751	COG2385	sporulation resulting in formation of a cellular spore
SynSYN20_02752	COG1234	tRNA 3'-trailer cleavage
SynSYN20_02753	COG2010	Cytochrome c
SynSYN20_02756	COG2264	protein methyltransferase activity
SynSYN20_02757	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynSYN20_02761	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynSYN20_02773	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynSYN20_02774	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynSYN20_02777	COG0459	protein refolding
SynSYN20_02779	COG0459	protein refolding
SynSYN20_02780	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynSYN20_02781	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynSYN20_02782	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynSYN20_02786	COG0387	Pfam Sodium calcium exchanger
SynSYN20_02787	COG0006	proline dipeptidase activity
SynSYN20_02788	COG1253	flavin adenine dinucleotide binding
SynSYN20_02789	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynSYN20_02791	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynSYN20_02791	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynSYN20_02792	COG0686	Belongs to the AlaDH PNT family
SynSYN20_02796	COG3012	SEC-C Motif Domain Protein
SynSYN20_02797	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynSYN20_02799	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynSYN20_02801	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynSYN20_02802	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynSYN20_02803	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynSYN20_02804	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynSYN20_02805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynSYN20_02806	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynSYN20_02807	COG0356	it plays a direct role in the translocation of protons across the membrane
SynSYN20_02809	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynSYN20_02810	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynSYN20_02814	COG0772	Belongs to the SEDS family
SynSYN20_02816	COG1333	cytochrome c biogenesis protein
SynSYN20_02817	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynSYN20_02820	COG0347	Belongs to the P(II) protein family
SynSYN20_02823	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynSYN20_02824	COG0114	fumarate hydratase activity
SynSYN20_02825	COG4581	dead DEAH box helicase
SynSYN20_02826	COG0156	8-amino-7-oxononanoate synthase activity
SynSYN20_02828	COG2226	methyltransferase
SynSYN20_02829	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynSYN20_02831	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynSYN20_02834	COG0357	Ribosomal RNA small subunit methyltransferase G
SynSYN20_02842	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynSYN20_02845	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynSYN20_02846	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynSYN20_02847	COG0085	RNA polymerase activity
SynSYN20_02849	COG0084	hydrolase, TatD family'
SynSYN20_02850	COG0268	Binds directly to 16S ribosomal RNA
SynSYN20_02851	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynSYN20_02852	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynSYN20_02853	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynSYN20_02855	COG2205	protein histidine kinase activity
SynSYN20_02855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynSYN20_02857	COG0641	radical SAM
SynSYN20_02859	COG0779	Required for maturation of 30S ribosomal subunits
SynSYN20_02860	COG0195	Participates in both transcription termination and antitermination
SynSYN20_02862	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynSYN20_02874	COG2988	succinylglutamate desuccinylase activity
SynSYN20_02875	COG0435	Glutathione S-transferase
SynSYN20_02877	COG0488	(ABC) transporter
SynSYN20_02880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynSYN20_02881	COG3842	ATPase activity
SynSYN20_02882	COG1193	negative regulation of DNA recombination
SynSYN20_02884	COG0113	porphobilinogen synthase activity
SynSYN20_02885	COG0484	heat shock protein binding
SynSYN20_02887	COG0659	secondary active sulfate transmembrane transporter activity
SynSYN20_02961	COG0116	Belongs to the methyltransferase superfamily
SynSYN20_02965	COG1196	nuclear chromosome segregation
SynSYN20_02967	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynSYN20_02970	COG0439	Biotin carboxylase
SynSYN20_02973	COG0515	serine threonine protein kinase
SynSYN20_02976	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynSYN20_02977	COG4178	(ABC) transporter
SynSYN20_02978	COG0537	adenosine 5'-monophosphoramidase activity
SynSYN20_02979	COG0606	chelatase, subunit chli
SynSYN20_02981	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynSYN20_02984	COG0242	peptide deformylase activity
SynSYN20_02986	COG0235	Class ii aldolase
SynSYN20_02987	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynSYN20_02989	COG2226	methyltransferase
SynSYN20_02990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynSYN20_02991	COG0719	Fe-S assembly protein
SynSYN20_02992	COG0396	ATPase activity
SynSYN20_02993	COG0719	Fe-S assembly protein
SynSYN20_02994	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynSYN20_02998	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynSYN20_03001	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SynSYN20_03005	COG0033	Phosphoglucomutase
SynSYN20_03013	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynSYN20_03014	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynSYN20_03015	COG0175	sulfate reduction
SynSYN20_03016	COG1252	NADH dehydrogenase
SynSYN20_03017	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynSYN20_03018	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynSYN20_03019	COG0569	domain protein
SynSYN20_03020	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynSYN20_03025	COG0488	(ABC) transporter
SynSYN20_03027	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynSYN20_03030	COG1643	Atp-dependent helicase
SynSYN20_03033	COG1570	exodeoxyribonuclease VII activity
SynSYN20_03047	COG1968	undecaprenyl-diphosphatase activity
SynSYN20_03049	COG1555	photosystem II stabilization
SynSYN20_03050	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynSYN20_03051	COG4243	Vitamin k epoxide reductase
SynSYN20_03053	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynSYN20_03056	COG1032	radical SAM domain protein
SynSYN20_03066	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynSYN20_03068	COG0457	Tetratricopeptide repeat
SynSYN20_03068	COG0463	Glycosyl transferase, family 2
SynSYN20_03069	COG1587	Uroporphyrinogen-III synthase
SynSYN20_03072	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynSYN20_03073	COG0316	Belongs to the HesB IscA family
SynSYN20_03076	COG1090	epimerase
SynSYN20_03081	COG0484	heat shock protein binding
SynSYN20_03082	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynSYN20_03083	COG3659	wide pore channel activity
SynSYN20_03086	COG3659	wide pore channel activity
SynSYN20_03095	COG1122	ATPase activity
SynSYN20_03099	COG0745	RESPONSE REGULATOR receiver
SynSYN20_03101	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynSYN20_03102	COG2217	Heavy metal translocating P-type atpase
SynSYN20_03104	COG3063	Type IV pilus biogenesis stability protein PilW
SynSYN20_03105	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynSYN20_03108	COG0416	fatty acid biosynthetic process
SynSYN20_03109	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynSYN20_03110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynSYN20_03113	COG1214	PFAM Peptidase M22, glycoprotease
SynSYN20_03115	COG0617	tRNA 3'-terminal CCA addition
SynSYN20_03117	COG1562	ergosterol biosynthetic process
SynSYN20_03118	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynSYN20_03118	COG0493	'glutamate synthase
SynSYN20_03121	COG0583	DNA-binding transcription factor activity
SynSYN20_03123	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynSYN20_03124	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynSYN20_03127	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynSYN20_03129	COG2197	response regulator
SynSYN20_03132	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynSYN20_03133	COG0713	ATP synthesis coupled electron transport
SynSYN20_03134	COG0839	Belongs to the complex I subunit 6 family
SynSYN20_03135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynSYN20_03136	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynSYN20_03137	COG0372	Belongs to the citrate synthase family
SynSYN20_03141	COG1420	regulation of RNA biosynthetic process
SynSYN20_03144	COG0133	tryptophan synthase activity
SynSYN20_03146	COG0023	Translation Initiation Factor
SynSYN20_03147	COG0529	Catalyzes the synthesis of activated sulfate
SynSYN20_03148	COG0628	permease
SynSYN20_03149	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynSYN20_03151	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynSYN20_03152	COG0564	pseudouridine synthase activity
SynSYN20_03153	COG0745	RESPONSE REGULATOR receiver
SynSYN20_03155	COG1104	cysteine desulfurase activity
SynSYN20_03159	COG0275	rRNA processing
SynSYN20_03160	COG0649	NAD binding
SynSYN20_03161	COG0824	Thioesterase
SynSYN20_03163	COG4948	Mandelate Racemase Muconate Lactonizing
SynSYN20_03164	COG1575	Belongs to the MenA family. Type 1 subfamily
SynSYN20_03166	COG0189	ligase activity
SynSYN20_03167	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynSYN20_03168	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynSYN20_03170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynSYN20_03171	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynSYN20_03174	COG0252	asparaginase activity
SynSYN20_03175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynSYN20_03176	COG0018	arginyl-trna synthetase
SynSYN20_03192	COG0157	Belongs to the NadC ModD family
SynSYN20_03196	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynSYN20_03200	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynSYN20_03202	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SynSYN20_03203	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynSYN20_03204	COG4172	Belongs to the ABC transporter superfamily
SynSYN20_03208	COG2197	response regulator
SynSYN20_03210	COG0564	pseudouridine synthase activity
SynSYN20_03212	COG0589	response to stress
SynSYN20_03213	COG0126	phosphoglycerate kinase activity
SynSYN20_03223	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynSYN20_03224	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynSYN20_03226	COG1450	Type ii and iii secretion system protein
SynSYN20_03230	COG0167	dihydroorotate dehydrogenase activity
SynSYN20_03231	COG0328	RNA-DNA hybrid ribonuclease activity
SynSYN20_03235	COG0222	ribosome binding
SynSYN20_03236	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynSYN20_03237	COG0081	regulation of translation
SynSYN20_03238	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynSYN20_03239	COG0250	Participates in transcription elongation, termination and antitermination
SynSYN20_03240	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynSYN20_03241	COG0542	response to heat
SynSYN20_03242	COG0346	lactoylglutathione lyase activity
SynSYN20_03243	COG0148	phosphopyruvate hydratase activity
SynSYN20_03245	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynSYN20_03248	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynSYN20_03250	COG0237	dephospho-CoA kinase activity
SynSYN20_03253	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynSYN20_03254	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynSYN20_03254	COG2022	thiamine diphosphate biosynthetic process
SynSYN20_03255	COG0105	UTP biosynthetic process
SynSYN20_03256	COG1166	arginine decarboxylase activity
SynSYN20_03258	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynSYN20_03259	COG1803	Methylglyoxal synthase
SynSYN20_03260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynSYN20_03262	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynSYN20_03267	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SynSYN20_03269	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SynSYN20_03270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynSYN20_03270	COG0426	domain, Protein
SynSYN20_03271	COG0426	domain, Protein
SynSYN20_03271	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynSYN20_03272	COG1773	rubredoxin
SynSYN20_03274	COG1741	Belongs to the pirin family
SynSYN20_03279	COG0509	glycine decarboxylation via glycine cleavage system
SynSYN20_03280	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynSYN20_03284	COG0359	binds to the 23S rRNA
SynSYN20_03285	COG0305	Participates in initiation and elongation during chromosome replication
SynSYN20_03285	COG0305	Participates in initiation and elongation during chromosome replication
SynSYN20_03285	COG1372	Participates in initiation and elongation during chromosome replication
SynSYN20_03285	COG1372	Participates in initiation and elongation during chromosome replication
SynSYN20_03296	COG0445	tRNA wobble uridine modification
SynSYN20_03307	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynSYN20_03310	COG0398	Pfam SNARE associated Golgi protein
SynSYN20_03314	COG1131	(ABC) transporter
SynSYN20_03315	COG0668	transmembrane transport
SynSYN20_03316	COG0525	valine-tRNA ligase activity
SynSYN20_03321	COG4221	oxidoreductase activity
SynSYN20_03329	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynSYN20_03336	COG3956	TIGRFAM MazG family protein
SynSYN20_03337	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynSYN20_03338	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynSYN20_03339	COG0010	Belongs to the arginase family
SynSYN20_03341	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynSYN20_03342	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynSYN20_03343	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynSYN20_03344	COG0783	Belongs to the Dps family
SynSYN20_03346	COG0504	CTP synthase activity
SynSYN20_03347	COG0602	queuosine metabolic process
SynSYN20_03352	COG4574	serine-type endopeptidase inhibitor activity
SynSYN20_03353	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynSYN20_03356	COG1113	amino acid transport
SynSYN20_03360	COG0559	Belongs to the binding-protein-dependent transport system permease family
SynSYN20_03362	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynSYN20_03363	COG0830	nickel cation binding
SynSYN20_03364	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynSYN20_03365	COG0829	nickel cation binding
SynSYN20_03366	COG0831	urea catabolic process
SynSYN20_03367	COG0832	Belongs to the urease beta subunit family
SynSYN20_03368	COG0804	urea catabolic process
SynSYN20_03371	COG2308	Evidence 4 Homologs of previously reported genes of
SynSYN20_03375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynSYN20_03376	COG0746	molybdenum cofactor guanylyltransferase activity
SynSYN20_03377	COG2223	nitrite transmembrane transporter activity
SynSYN20_03378	COG0243	molybdopterin cofactor binding
SynSYN20_03383	COG0315	cyclic pyranopterin monophosphate synthase activity
SynSYN20_03384	COG0303	'Molybdopterin
SynSYN20_03385	COG0314	molybdopterin synthase activity
SynSYN20_03387	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynSYN20_03388	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynSYN20_03391	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynSYN20_03393	COG2116	formate transmembrane transporter activity
SynSYN20_03395	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynSYN20_03397	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynSYN20_03399	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynSYN20_03400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynSYN20_03401	COG0170	dolichyl monophosphate biosynthetic process
SynSYN20_03402	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynSYN20_03403	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynSYN20_03408	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynSYN20_03410	COG0788	formyltetrahydrofolate deformylase activity
SynSYN20_03413	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynSYN20_03415	COG0443	Heat shock 70 kDa protein
SynSYN20_03416	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynSYN20_03418	COG0360	Binds together with S18 to 16S ribosomal RNA
SynSYN20_03420	COG0137	argininosuccinate synthase activity
SynSYN20_03423	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynSYN20_03428	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynSYN20_03429	COG0438	transferase activity, transferring glycosyl groups
SynSYN20_03432	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynSYN20_03433	COG0497	DNA recombination
SynSYN20_03434	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynSYN20_03436	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine