locus-tag	class	description
BM449_00010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM449_00020	COG0456	acetyltransferase
BM449_00025	COG0596	Alpha beta hydrolase
BM449_00030	COG1132	(ABC) transporter
BM449_00035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BM449_00040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM449_00045	COG3842	ATPase activity
BM449_00050	COG0251	oxidation-reduction process
BM449_00155	COG1205	dead DEAH box helicase
BM449_00155	COG1111	helicase
BM449_00195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BM449_00235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM449_00270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM449_00590	COG3657	addiction module killer protein
BM449_00595	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM449_00605	COG2801	Transposase and inactivated derivatives
BM449_00605	COG3415	Transposase
BM449_00615	COG0011	TIGRFAM Protein of
BM449_00670	COG3039	Transposase
BM449_00760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BM449_00785	COG2814	Major facilitator Superfamily
BM449_00810	COG2801	Transposase and inactivated derivatives
BM449_00810	COG3415	Transposase
BM449_00815	COG0385	Bile acid
BM449_00845	COG0415	Belongs to the DNA photolyase family
BM449_00870	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM449_00875	COG3657	addiction module killer protein
BM449_00895	COG4974	Belongs to the 'phage' integrase family
BM449_00905	COG4974	Belongs to the 'phage' integrase family
BM449_00915	COG3046	protein related to deoxyribodipyrimidine photolyase
BM449_00920	COG0415	Belongs to the DNA photolyase family
BM449_00935	COG2124	cytochrome p450
BM449_00960	COG0730	response to heat
BM449_00965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM449_00990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM449_00995	COG0723	plastoquinol--plastocyanin reductase activity
BM449_01010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM449_01020	COG1294	oxidase, subunit
BM449_01025	COG1271	oxidase subunit
BM449_01040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BM449_01060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BM449_01070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BM449_01105	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BM449_01110	COG0732	type I restriction modification DNA specificity domain
BM449_01180	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BM449_01185	COG2326	polyphosphate kinase activity
BM449_01235	COG2217	Heavy metal translocating P-type atpase
BM449_01285	COG1131	(ABC) transporter
BM449_01295	COG3264	Mechanosensitive ion channel
BM449_01295	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BM449_01330	COG4974	Belongs to the 'phage' integrase family
BM449_01415	COG0697	spore germination
BM449_01445	COG0745	RESPONSE REGULATOR receiver
BM449_01450	COG5002	protein histidine kinase activity
BM449_01510	COG2801	Transposase and inactivated derivatives
BM449_01510	COG3415	Transposase
BM449_01530	COG2826	transposase and inactivated derivatives, IS30 family
BM449_01555	COG4584	PFAM Integrase catalytic
BM449_01575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BM449_01620	COG3588	fructose-bisphosphate aldolase
BM449_01625	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BM449_01625	COG1793	dna ligase
BM449_01655	COG1793	dna ligase
BM449_01660	COG1201	RNA secondary structure unwinding
BM449_01675	COG0625	glutathione transferase activity
BM449_01685	COG0517	IMP dehydrogenase activity
BM449_01685	COG0516	GMP reductase activity
BM449_01690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BM449_01700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BM449_01710	COG2197	response regulator
BM449_01715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BM449_01720	COG0114	fumarate hydratase activity
BM449_01745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BM449_01760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BM449_01765	COG0668	transmembrane transport
BM449_01775	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BM449_01780	COG0473	3-isopropylmalate dehydrogenase activity
BM449_01785	COG3954	Phosphoribulokinase
BM449_01795	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BM449_01800	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BM449_01815	COG0191	fructose-bisphosphate aldolase activity
BM449_01820	COG1615	UPF0182 protein
BM449_01825	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BM449_01830	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BM449_01840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM449_01845	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BM449_01855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BM449_01855	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BM449_01870	COG2119	membrane
BM449_01880	COG0557	exoribonuclease II activity
BM449_01885	COG0163	prenyltransferase activity
BM449_01900	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BM449_01905	COG0312	modulator of DNA gyrase
BM449_01915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BM449_01965	COG2337	Toxic component of a toxin-antitoxin (TA) module
BM449_01980	COG0785	Cytochrome C biogenesis protein
BM449_01985	COG0659	secondary active sulfate transmembrane transporter activity
BM449_02030	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BM449_02065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BM449_02070	COG0271	Belongs to the BolA IbaG family
BM449_02085	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BM449_02105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BM449_02115	COG1074	ATP-dependent DNA helicase activity
BM449_02120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM449_02140	COG0513	Belongs to the DEAD box helicase family
BM449_02160	COG1132	(ABC) transporter
BM449_02170	COG1316	TRANSCRIPTIONal
BM449_02175	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BM449_02175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BM449_02185	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BM449_02190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BM449_02200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BM449_02230	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BM449_02235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BM449_02240	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BM449_02245	COG0019	diaminopimelate decarboxylase activity
BM449_02255	COG0542	response to heat
BM449_02280	COG0575	Belongs to the CDS family
BM449_02290	COG1982	Orn Lys Arg decarboxylase major
BM449_02295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM449_02305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM449_02310	COG1187	pseudouridine synthase activity
BM449_02325	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
BM449_02340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BM449_02350	COG0308	aminopeptidase N
BM449_02365	COG2205	protein histidine kinase activity
BM449_02380	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BM449_02385	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BM449_02390	COG3409	Peptidoglycan-binding domain 1 protein
BM449_02390	COG3429	Glucose-6-phosphate dehydrogenase subunit
BM449_02395	COG1797	cobyrinic acid a,c-diamide synthase activity
BM449_02400	COG0406	alpha-ribazole phosphatase activity
BM449_02410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM449_02425	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BM449_02430	COG1480	7TM receptor with intracellular HD hydrolase
BM449_02475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BM449_02490	COG1132	(ABC) transporter
BM449_02500	COG0149	triose-phosphate isomerase activity
BM449_02505	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BM449_02510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM449_02515	COG1131	(ABC) transporter
BM449_02520	COG0842	Transport permease protein
BM449_02520	COG1129	ABC transporter
BM449_02525	COG0842	Transport permease protein
BM449_02540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BM449_02545	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BM449_02555	COG0778	Nitroreductase
BM449_02560	COG0435	Glutathione S-transferase
BM449_02565	COG1429	ligase activity, forming nitrogen-metal bonds
BM449_02570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BM449_02580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BM449_02625	COG0745	RESPONSE REGULATOR receiver
BM449_02630	COG2205	protein histidine kinase activity
BM449_02635	COG2326	polyphosphate kinase activity
BM449_02665	COG0438	transferase activity, transferring glycosyl groups
BM449_02670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BM449_02675	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BM449_02685	COG0740	serine-type endopeptidase activity
BM449_02690	COG0740	serine-type endopeptidase activity
BM449_02695	COG4956	integral membrane protein (PIN domain superfamily)
BM449_02700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BM449_02715	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BM449_02735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BM449_02740	COG4948	Mandelate Racemase Muconate Lactonizing
BM449_02760	COG0402	S-adenosylhomocysteine deaminase activity
BM449_02775	COG0285	dihydrofolate synthase activity
BM449_02780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BM449_02785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BM449_02790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BM449_02805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM449_02810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM449_02815	COG0134	indole-3-glycerol-phosphate synthase activity
BM449_02825	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BM449_02830	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BM449_02840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BM449_02845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BM449_02850	COG1104	cysteine desulfurase activity
BM449_02860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM449_02870	COG0706	membrane insertase activity
BM449_02880	COG0594	ribonuclease P activity
BM449_02885	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BM449_02900	COG0616	signal peptide processing
BM449_02905	COG0697	spore germination
BM449_02910	COG0438	transferase activity, transferring glycosyl groups
BM449_02925	COG1842	Phage shock protein A
BM449_02930	COG3118	belongs to the thioredoxin family
BM449_02935	COG0436	Aminotransferase
BM449_02940	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BM449_02940	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BM449_02945	COG0739	heme binding
BM449_02950	COG1136	(ABC) transporter
BM449_02950	COG0577	efflux transmembrane transporter activity
BM449_02960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BM449_02975	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BM449_03010	COG1845	cytochrome c oxidase, subunit III
BM449_03015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BM449_03030	COG0109	protoheme IX farnesyltransferase activity
BM449_03050	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BM449_03055	COG0459	protein refolding
BM449_03065	COG1028	Short-chain dehydrogenase reductase Sdr
BM449_03070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BM449_03080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BM449_03085	COG1619	proteins homologs of microcin C7 resistance protein MccF
BM449_03090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BM449_03095	COG0248	Ppx GppA phosphatase
BM449_03125	COG0739	heme binding
BM449_03130	COG0723	plastoquinol--plastocyanin reductase activity
BM449_03140	COG0805	protein transport
BM449_03150	COG0194	GDP metabolic process
BM449_03165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BM449_03185	COG0012	GTP binding
BM449_03240	COG0460	homoserine dehydrogenase
BM449_03245	COG2166	iron-sulfur cluster assembly
BM449_03260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BM449_03265	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BM449_03270	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BM449_03285	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BM449_03290	COG2010	Cytochrome c
BM449_03300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BM449_03305	COG1611	Belongs to the LOG family
BM449_03310	COG3118	belongs to the thioredoxin family
BM449_03315	COG0516	GMP reductase activity
BM449_03320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM449_03330	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BM449_03335	COG0644	oxidoreductase
BM449_03345	COG1543	Belongs to the glycosyl hydrolase 57 family
BM449_03355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BM449_03360	COG0395	ABC-type sugar transport system, permease component
BM449_03370	COG2119	membrane
BM449_03380	COG0861	Integral membrane protein TerC family
BM449_03395	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BM449_03405	COG0793	Belongs to the peptidase S41A family
BM449_03410	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BM449_03415	COG1573	uracil-dna glycosylase
BM449_03420	COG0436	Aminotransferase
BM449_03425	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BM449_03430	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BM449_03430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BM449_03435	COG3639	organic phosphonate transmembrane transporter activity
BM449_03445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM449_03450	COG1836	PFAM Integral membrane protein DUF92
BM449_03470	COG1122	ATPase activity
BM449_03475	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BM449_03490	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BM449_03525	COG1091	dTDP-4-dehydrorhamnose reductase activity
BM449_03530	COG1088	dTDP-glucose 4,6-dehydratase activity
BM449_03565	COG0281	malic enzyme
BM449_03570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BM449_03575	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BM449_03580	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BM449_03585	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BM449_03595	COG0513	Belongs to the DEAD box helicase family
BM449_03605	COG0529	Catalyzes the synthesis of activated sulfate
BM449_03605	COG2046	Belongs to the sulfate adenylyltransferase family
BM449_03615	COG0529	Catalyzes the synthesis of activated sulfate
BM449_03635	COG0752	glycyl-tRNA synthetase alpha subunit
BM449_03640	COG2226	methyltransferase
BM449_03650	COG0107	imidazoleglycerol-phosphate synthase activity
BM449_03660	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BM449_03665	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BM449_03670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BM449_03670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BM449_03675	COG3695	enzyme binding
BM449_03680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BM449_03705	COG0745	RESPONSE REGULATOR receiver
BM449_03710	COG5002	protein histidine kinase activity
BM449_03710	COG3850	Histidine kinase
BM449_03750	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BM449_03755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BM449_03760	COG0750	zinc metalloprotease
BM449_03765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BM449_03770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BM449_03775	COG1185	polyribonucleotide nucleotidyltransferase activity
BM449_03780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BM449_03810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM449_03815	COG0776	regulation of translation
BM449_03820	COG1523	belongs to the glycosyl hydrolase 13 family
BM449_03825	COG1119	ATPase activity
BM449_03850	COG2211	Major facilitator Superfamily
BM449_03855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BM449_03870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BM449_03875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BM449_03880	COG1799	cell septum assembly
BM449_03885	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BM449_03895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BM449_03910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM449_03935	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BM449_03950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BM449_03955	COG1121	(ABC) transporter
BM449_03965	COG1012	belongs to the aldehyde dehydrogenase family
BM449_03975	COG0514	ATP-dependent DNA helicase (RecQ)
BM449_03985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BM449_03990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BM449_03995	COG0366	Alpha amylase catalytic
BM449_04005	COG0395	ABC-type sugar transport system, permease component
BM449_04015	COG1653	transport
BM449_04020	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BM449_04055	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BM449_04060	COG0235	Class ii aldolase
BM449_04065	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BM449_04115	COG1968	undecaprenyl-diphosphatase activity
BM449_04125	COG1555	photosystem II stabilization
BM449_04130	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BM449_04135	COG4243	Vitamin k epoxide reductase
BM449_04140	COG0434	BtpA family
BM449_04145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BM449_04155	COG1032	radical SAM domain protein
BM449_04185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BM449_04205	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BM449_04210	COG1472	Belongs to the glycosyl hydrolase 3 family
BM449_04220	COG0457	Tetratricopeptide repeat
BM449_04220	COG0463	Glycosyl transferase, family 2
BM449_04225	COG1587	Uroporphyrinogen-III synthase
BM449_04240	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BM449_04245	COG0316	Belongs to the HesB IscA family
BM449_04265	COG1090	epimerase
BM449_04270	COG3263	regulation of cellular component size
BM449_04280	COG0484	heat shock protein binding
BM449_04285	COG3659	wide pore channel activity
BM449_04290	COG3659	wide pore channel activity
BM449_04320	COG1122	ATPase activity
BM449_04330	COG0745	RESPONSE REGULATOR receiver
BM449_04340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BM449_04345	COG2217	Heavy metal translocating P-type atpase
BM449_04350	COG0457	Tetratricopeptide repeat
BM449_04355	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BM449_04370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BM449_04375	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BM449_04390	COG1214	PFAM Peptidase M22, glycoprotease
BM449_04400	COG0617	tRNA 3'-terminal CCA addition
BM449_04405	COG0724	RNA recognition motif
BM449_04415	COG1562	ergosterol biosynthetic process
BM449_04420	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BM449_04420	COG0493	'glutamate synthase
BM449_04435	COG0583	DNA-binding transcription factor activity
BM449_04445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BM449_04450	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BM449_04465	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BM449_04475	COG2197	response regulator
BM449_04485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BM449_04490	COG0713	ATP synthesis coupled electron transport
BM449_04495	COG0839	Belongs to the complex I subunit 6 family
BM449_04500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BM449_04505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BM449_04510	COG0372	Belongs to the citrate synthase family
BM449_04515	COG2062	phosphohistidine phosphatase, SixA
BM449_04525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BM449_04530	COG1420	regulation of RNA biosynthetic process
BM449_04540	COG0133	tryptophan synthase activity
BM449_04545	COG0023	Translation Initiation Factor
BM449_04555	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BM449_04565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM449_04570	COG0564	pseudouridine synthase activity
BM449_04575	COG0745	RESPONSE REGULATOR receiver
BM449_04585	COG1104	cysteine desulfurase activity
BM449_04635	COG0824	Thioesterase
BM449_04640	COG1597	lipid kinase activity
BM449_04640	COG1803	Methylglyoxal synthase
BM449_04650	COG0521	Mo-molybdopterin cofactor biosynthetic process
BM449_04675	COG0071	Belongs to the small heat shock protein (HSP20) family
BM449_04680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BM449_04685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM449_04710	COG0347	Belongs to the P(II) protein family
BM449_04725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM449_04725	COG0426	domain, Protein
BM449_04730	COG0426	domain, Protein
BM449_04730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM449_04735	COG1741	Belongs to the pirin family
BM449_04760	COG0509	glycine decarboxylation via glycine cleavage system
BM449_04765	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BM449_04785	COG0359	binds to the 23S rRNA
BM449_04790	COG0305	Participates in initiation and elongation during chromosome replication
BM449_04790	COG1372	Participates in initiation and elongation during chromosome replication
BM449_04790	COG0305	Participates in initiation and elongation during chromosome replication
BM449_04790	COG1372	Participates in initiation and elongation during chromosome replication
BM449_04800	COG0445	tRNA wobble uridine modification
BM449_04825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BM449_04835	COG0398	Pfam SNARE associated Golgi protein
BM449_04860	COG3119	arylsulfatase activity
BM449_04865	COG0525	valine-tRNA ligase activity
BM449_04880	COG3220	belongs to the UPF0276 family
BM449_04915	COG0523	cobalamin synthesis protein
BM449_04950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BM449_04955	COG1121	(ABC) transporter
BM449_04975	COG0523	cobalamin synthesis protein
BM449_04995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BM449_05015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM449_05020	COG0678	peroxiredoxin activity
BM449_05040	COG0438	transferase activity, transferring glycosyl groups
BM449_05075	COG0659	secondary active sulfate transmembrane transporter activity
BM449_05085	COG0745	RESPONSE REGULATOR receiver
BM449_05105	COG3237	CsbD-like
BM449_05115	COG1012	belongs to the aldehyde dehydrogenase family
BM449_05125	COG3237	CsbD-like
BM449_05155	COG3237	CsbD-like
BM449_05160	COG4251	negative regulation of phosphorylation
BM449_05175	COG3220	belongs to the UPF0276 family
BM449_05195	COG3956	TIGRFAM MazG family protein
BM449_05200	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BM449_05205	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BM449_05210	COG0010	Belongs to the arginase family
BM449_05220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BM449_05225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BM449_05230	COG0783	Belongs to the Dps family
BM449_05240	COG0602	queuosine metabolic process
BM449_05250	COG0124	histidyl-tRNA synthetase
BM449_05255	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BM449_05285	COG4447	cellulose binding
BM449_05290	COG1773	rubredoxin
BM449_05295	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BM449_05300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BM449_05305	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BM449_05310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BM449_05315	COG3842	ATPase activity
BM449_05325	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BM449_05325	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BM449_05340	COG3631	Ketosteroid isomerase-related protein
BM449_05380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BM449_05435	COG0556	nucleotide-excision repair
BM449_05590	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BM449_05595	COG0494	nUDIX hydrolase
BM449_05600	COG0415	Belongs to the DNA photolyase family
BM449_05625	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BM449_05635	COG0131	Imidazoleglycerol-phosphate dehydratase
BM449_05640	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
BM449_05665	COG0668	transmembrane transport
BM449_05710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BM449_05715	COG3119	arylsulfatase activity
BM449_05730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BM449_05735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BM449_05755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BM449_05780	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BM449_05790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BM449_05795	COG0390	transport system, permease component
BM449_05810	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BM449_05830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BM449_05850	COG0351	phosphomethylpyrimidine kinase
BM449_05855	COG0366	Alpha amylase catalytic
BM449_05860	COG0366	Alpha amylase catalytic
BM449_05875	COG2217	Heavy metal translocating P-type atpase
BM449_05915	COG2226	methyltransferase
BM449_05920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BM449_05935	COG1191	sigma factor activity
BM449_05950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BM449_05955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM449_05965	COG0243	molybdopterin cofactor binding
BM449_05970	COG2223	nitrite transmembrane transporter activity
BM449_05975	COG1017	nitric oxide dioxygenase activity
BM449_05975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BM449_05985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BM449_06000	COG0237	dephospho-CoA kinase activity
BM449_06005	COG4782	Protein conserved in bacteria
BM449_06010	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BM449_06015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BM449_06015	COG2022	thiamine diphosphate biosynthetic process
BM449_06020	COG0105	UTP biosynthetic process
BM449_06025	COG1166	arginine decarboxylase activity
BM449_06030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM449_06030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BM449_06040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BM449_06050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BM449_06060	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BM449_06075	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM449_06100	COG3657	addiction module killer protein
BM449_06105	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BM449_06135	COG0148	phosphopyruvate hydratase activity
BM449_06140	COG0346	lactoylglutathione lyase activity
BM449_06145	COG0542	response to heat
BM449_06150	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BM449_06155	COG0250	Participates in transcription elongation, termination and antitermination
BM449_06160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BM449_06165	COG0081	regulation of translation
BM449_06170	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BM449_06175	COG0222	ribosome binding
BM449_06190	COG0167	dihydroorotate dehydrogenase activity
BM449_06210	COG1450	Type ii and iii secretion system protein
BM449_06220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM449_06225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BM449_06235	COG2084	Dehydrogenase
BM449_06245	COG0126	phosphoglycerate kinase activity
BM449_06250	COG0589	response to stress
BM449_06255	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BM449_06260	COG0564	pseudouridine synthase activity
BM449_06265	COG0038	chloride channel
BM449_06270	COG4172	Belongs to the ABC transporter superfamily
BM449_06275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BM449_06280	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BM449_06295	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BM449_06300	COG0157	Belongs to the NadC ModD family
BM449_06315	COG0641	radical SAM
BM449_06320	COG0018	arginyl-trna synthetase
BM449_06325	COG2351	hydroxyisourate hydrolase activity
BM449_06350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BM449_06355	COG1752	Esterase of the alpha-beta hydrolase superfamily
BM449_06365	COG0668	transmembrane transport
BM449_06375	COG4325	translation initiation factor activity
BM449_06380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BM449_06415	COG0512	Glutamine amidotransferase of anthranilate synthase
BM449_06420	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BM449_06425	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BM449_06435	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BM449_06440	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BM449_06445	COG0189	ligase activity
BM449_06455	COG1575	Belongs to the MenA family. Type 1 subfamily
BM449_06470	COG2226	methyltransferase
BM449_06480	COG0314	molybdopterin synthase activity
BM449_06485	COG0303	'Molybdopterin
BM449_06490	COG0315	cyclic pyranopterin monophosphate synthase activity
BM449_06500	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BM449_06505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM449_06510	COG0170	dolichyl monophosphate biosynthetic process
BM449_06520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BM449_06525	COG1049	propionate catabolic process, 2-methylcitrate cycle
BM449_06530	COG0038	chloride channel
BM449_06550	COG0788	formyltetrahydrofolate deformylase activity
BM449_06565	COG0443	Heat shock 70 kDa protein
BM449_06570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BM449_06580	COG0360	Binds together with S18 to 16S ribosomal RNA
BM449_06585	COG0137	argininosuccinate synthase activity
BM449_06600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BM449_06615	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BM449_06635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BM449_06640	COG0497	DNA recombination
BM449_06645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BM449_06655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BM449_06660	COG0592	DNA-directed DNA polymerase activity
BM449_06670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BM449_06675	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BM449_06680	COG2818	Glycosylase
BM449_06685	COG2801	Transposase and inactivated derivatives
BM449_06685	COG3415	Transposase
BM449_06695	COG0277	FAD linked oxidase domain protein
BM449_06720	COG0475	glutathione-regulated potassium exporter activity
BM449_06730	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BM449_06735	COG0058	SHG alpha-glucan phosphorylase activity
BM449_06740	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BM449_06765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BM449_06795	COG1487	ribonuclease activity
BM449_06820	COG0571	ribonuclease III activity
BM449_06840	COG0709	Synthesizes selenophosphate from selenide and ATP
BM449_06845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BM449_06855	COG0058	SHG alpha-glucan phosphorylase activity
BM449_06870	COG2308	Evidence 4 Homologs of previously reported genes of
BM449_06875	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BM449_06885	COG2116	formate transmembrane transporter activity
BM449_06890	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BM449_06900	COG0832	Belongs to the urease beta subunit family
BM449_06905	COG0831	urea catabolic process
BM449_06915	COG2211	Major facilitator Superfamily
BM449_06930	COG0829	nickel cation binding
BM449_06935	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BM449_06940	COG0830	nickel cation binding
BM449_06945	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BM449_06965	COG0411	ABC transporter
BM449_06985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BM449_06990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BM449_06995	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BM449_07000	COG0515	serine threonine protein kinase
BM449_07010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BM449_07040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BM449_07045	COG0745	RESPONSE REGULATOR receiver
BM449_07050	COG1653	transport
BM449_07070	COG0629	single-stranded DNA binding
BM449_07075	COG0586	Pfam SNARE associated Golgi protein
BM449_07080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BM449_07085	COG0802	atpase or kinase
BM449_07090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM449_07110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM449_07115	COG2239	Acts as a magnesium transporter
BM449_07120	COG0386	Belongs to the glutathione peroxidase family
BM449_07125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BM449_07130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BM449_07140	COG0187	DNA topoisomerase II activity
BM449_07140	COG1372	Participates in initiation and elongation during chromosome replication
BM449_07145	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BM449_07150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BM449_07155	COG1725	Transcriptional regulator
BM449_07160	COG1045	serine acetyltransferase
BM449_07165	COG0653	protein targeting
BM449_07190	COG0438	transferase activity, transferring glycosyl groups
BM449_07200	COG0438	transferase activity, transferring glycosyl groups
BM449_07250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BM449_07275	COG2082	Precorrin-8x methylmutase
BM449_07290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BM449_07295	COG0556	nucleotide-excision repair
BM449_07310	COG0037	tRNA processing
BM449_07320	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BM449_07325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BM449_07330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BM449_07335	COG0544	peptidyl-prolyl cis-trans isomerase activity
BM449_07340	COG0740	serine-type endopeptidase activity
BM449_07345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BM449_07355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BM449_07360	COG1215	transferase activity, transferring glycosyl groups
BM449_07365	COG2385	sporulation resulting in formation of a cellular spore
BM449_07370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BM449_07375	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BM449_07390	COG2022	thiamine diphosphate biosynthetic process
BM449_07400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BM449_07425	COG0519	Catalyzes the synthesis of GMP from XMP
BM449_07425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BM449_07430	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BM449_07500	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BM449_07505	COG0511	ligase activity, forming carbon-carbon bonds
BM449_07510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BM449_07520	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BM449_07525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BM449_07530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BM449_07535	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BM449_07540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BM449_07545	COG1162	GTPase activity
BM449_07555	COG0484	heat shock protein binding
BM449_07560	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BM449_07580	COG2081	HI0933 family
BM449_07585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BM449_07595	COG0165	Argininosuccinate lyase
BM449_07600	COG2208	phosphoserine phosphatase activity
BM449_07605	COG0552	protein localization to endoplasmic reticulum
BM449_07610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BM449_07625	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BM449_07635	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BM449_07645	COG2755	lipolytic protein G-D-S-L family
BM449_07645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BM449_07650	COG0538	isocitrate dehydrogenase activity
BM449_07660	COG5398	heme oxygenase
BM449_07675	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BM449_07680	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BM449_07725	COG0438	transferase activity, transferring glycosyl groups
BM449_07730	COG0438	transferase activity, transferring glycosyl groups
BM449_07745	COG0438	transferase activity, transferring glycosyl groups
BM449_07760	COG0617	tRNA 3'-terminal CCA addition
BM449_07765	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BM449_07775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BM449_07790	COG1473	amidohydrolase
BM449_07805	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BM449_07825	COG0463	Glycosyl transferase, family 2
BM449_07830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BM449_07835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BM449_07840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BM449_07845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BM449_07850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BM449_07855	COG1253	flavin adenine dinucleotide binding
BM449_07880	COG0343	queuine tRNA-ribosyltransferase activity
BM449_07885	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BM449_07890	COG2205	protein histidine kinase activity
BM449_07905	COG0138	bifunctional purine biosynthesis protein purh
BM449_07920	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BM449_07925	COG0004	ammonium transporteR
BM449_07930	COG1489	DNA binding
BM449_07935	COG0728	peptidoglycan biosynthetic process
BM449_07960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BM449_07965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BM449_07970	COG1058	Belongs to the CinA family
BM449_07970	COG1546	Belongs to the CinA family
BM449_07975	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BM449_07980	COG0066	3-isopropylmalate dehydratase activity
BM449_08020	COG0193	aminoacyl-tRNA hydrolase activity
BM449_08035	COG4372	Transposase
BM449_08040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM449_08045	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BM449_08050	COG0717	Belongs to the dCTP deaminase family
BM449_08060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BM449_08075	COG0739	heme binding
BM449_08075	COG1196	nuclear chromosome segregation
BM449_08075	COG0741	lytic transglycosylase activity
BM449_08085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BM449_08100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BM449_08125	COG0484	heat shock protein binding
BM449_08130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BM449_08160	COG0076	glutamate decarboxylase activity
BM449_08200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM449_08205	COG0745	RESPONSE REGULATOR receiver
BM449_08210	COG5002	protein histidine kinase activity
BM449_08235	COG0725	ABC transporter, periplasmic molybdate-binding protein
BM449_08245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BM449_08255	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BM449_08260	COG1402	creatininase
BM449_08270	COG0540	Belongs to the ATCase OTCase family
BM449_08295	COG3536	Protein conserved in bacteria
BM449_08300	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BM449_08310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM449_08340	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BM449_08350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BM449_08360	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BM449_08365	COG0436	Aminotransferase
BM449_08370	COG1530	ribonuclease E activity
BM449_08375	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BM449_08390	COG2226	methyltransferase
BM449_08400	COG0051	transcription antitermination factor activity, RNA binding
BM449_08405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BM449_08410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BM449_08415	COG0049	tRNA binding
BM449_08435	COG0070	glutamate synthase
BM449_08435	COG0069	glutamate synthase activity
BM449_08435	COG0067	glutamate synthase
BM449_08440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BM449_08460	COG2885	chlorophyll binding
BM449_08465	COG2885	chlorophyll binding
BM449_08490	COG0463	Glycosyl transferase, family 2
BM449_08510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BM449_08520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BM449_08525	COG0254	rRNA binding
BM449_08530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BM449_08540	COG0101	tRNA pseudouridine synthase activity
BM449_08550	COG0202	RNA polymerase activity
BM449_08560	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BM449_08565	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BM449_08570	COG0563	adenylate kinase activity
BM449_08575	COG0201	protein transport
BM449_08580	COG0200	Binds to the 23S rRNA
BM449_08585	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BM449_08595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BM449_08605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BM449_08610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BM449_08615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BM449_08620	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BM449_08625	COG0255	Belongs to the universal ribosomal protein uL29 family
BM449_08630	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BM449_08635	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BM449_08640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BM449_08645	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BM449_08650	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BM449_08655	COG0089	rRNA binding
BM449_08660	COG0088	Forms part of the polypeptide exit tunnel
BM449_08665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BM449_08680	COG3854	ATPases associated with a variety of cellular activities
BM449_08695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BM449_08745	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BM449_08755	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BM449_08760	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BM449_08775	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BM449_08780	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BM449_08785	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BM449_08800	COG0772	Belongs to the SEDS family
BM449_08805	COG0489	protein tyrosine kinase activity
BM449_08810	COG0408	coproporphyrinogen oxidase activity
BM449_08860	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BM449_08865	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BM449_08870	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BM449_08870	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BM449_08875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BM449_08880	COG1413	lyase activity
BM449_08905	COG0237	dephospho-CoA kinase activity
BM449_08995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BM449_09025	COG1070	Carbohydrate kinase
BM449_09030	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BM449_09035	COG0546	phosphoglycolate phosphatase activity
BM449_09040	COG0539	negative regulation of cytoplasmic translation
BM449_09070	COG0589	response to stress
BM449_09085	COG2890	protein-(glutamine-N5) methyltransferase activity
BM449_09090	COG0009	L-threonylcarbamoyladenylate synthase
BM449_09120	COG0651	ATP synthesis coupled electron transport
BM449_09125	COG1006	Multisubunit Na H antiporter MnhC subunit
BM449_09140	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BM449_09145	COG2894	cell division
BM449_09150	COG0850	regulation of cytokinetic process
BM449_09155	COG1078	dGTPase activity
BM449_09160	COG0793	Belongs to the peptidase S41A family
BM449_09165	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BM449_09170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BM449_09225	COG1570	exodeoxyribonuclease VII activity
BM449_09235	COG1643	Atp-dependent helicase
BM449_09250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM449_09260	COG0488	(ABC) transporter
BM449_09275	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BM449_09280	COG0569	domain protein
BM449_09285	COG0450	alkyl hydroperoxide reductase
BM449_09290	COG3273	potassium ion transport
BM449_09290	COG0471	metal ion transport
BM449_09295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BM449_09300	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BM449_09305	COG1252	NADH dehydrogenase
BM449_09310	COG0175	sulfate reduction
BM449_09320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BM449_09345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BM449_09365	COG0033	Phosphoglucomutase
BM449_09405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BM449_09430	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
BM449_09435	COG0719	Fe-S assembly protein
BM449_09440	COG0396	ATPase activity
BM449_09445	COG0719	Fe-S assembly protein
BM449_09450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BM449_09470	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BM449_09475	COG3347	Dehydrogenase
BM449_09475	COG1028	Short-chain dehydrogenase reductase Sdr
BM449_09490	COG0242	peptide deformylase activity
BM449_09505	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BM449_09510	COG0606	chelatase, subunit chli
BM449_09515	COG0537	adenosine 5'-monophosphoramidase activity
BM449_09520	COG4178	(ABC) transporter
BM449_09530	COG0515	serine threonine protein kinase
BM449_09545	COG0439	Biotin carboxylase
BM449_09560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM449_09570	COG1196	nuclear chromosome segregation
BM449_09585	COG0116	Belongs to the methyltransferase superfamily
BM449_09610	COG4243	Vitamin k epoxide reductase
BM449_09615	COG0484	heat shock protein binding
BM449_09620	COG0113	porphobilinogen synthase activity
BM449_09630	COG1193	negative regulation of DNA recombination
BM449_09640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BM449_09650	COG0488	(ABC) transporter
BM449_09660	COG0435	Glutathione S-transferase
BM449_09665	COG2988	succinylglutamate desuccinylase activity
BM449_09685	COG4106	trans-aconitate 2-methyltransferase activity
BM449_09720	COG3266	domain, Protein
BM449_09720	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BM449_09730	COG0195	Participates in both transcription termination and antitermination
BM449_09735	COG0779	Required for maturation of 30S ribosomal subunits
BM449_09745	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BM449_09750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BM449_09755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BM449_09760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BM449_09765	COG0268	Binds directly to 16S ribosomal RNA
BM449_09770	COG0084	hydrolase, TatD family'
BM449_09775	COG0085	RNA polymerase activity
BM449_09780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BM449_09785	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BM449_09795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BM449_09805	COG2223	nitrite transmembrane transporter activity
BM449_09835	COG0357	Ribosomal RNA small subunit methyltransferase G
BM449_09840	COG0484	heat shock protein binding
BM449_09850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BM449_09855	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BM449_09875	COG4581	dead DEAH box helicase
BM449_09880	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BM449_09905	COG1799	cell septum assembly
BM449_09915	COG0724	RNA recognition motif
BM449_09920	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BM449_09935	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BM449_09955	COG1022	Amp-dependent synthetase and ligase
BM449_09960	COG0321	lipoyl(octanoyl) transferase activity
BM449_09965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BM449_09970	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BM449_09975	COG1381	Involved in DNA repair and RecF pathway recombination
BM449_09985	COG0438	transferase activity, transferring glycosyl groups
BM449_10000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BM449_10005	COG1231	oxidoreductase activity
BM449_10010	COG0284	orotidine-5'-phosphate decarboxylase activity
BM449_10015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BM449_10035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BM449_10050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM449_10060	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BM449_10065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BM449_10090	COG0151	Belongs to the GarS family
BM449_10095	COG5002	protein histidine kinase activity
BM449_10100	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BM449_10115	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BM449_10125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM449_10130	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BM449_10135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BM449_10140	COG0217	transcriptional regulatory protein
BM449_10145	COG0363	glucosamine-6-phosphate deaminase activity
BM449_10150	COG2247	cell wall binding repeat
BM449_10150	COG2385	sporulation resulting in formation of a cellular spore
BM449_10155	COG1234	tRNA 3'-trailer cleavage
BM449_10160	COG2010	Cytochrome c
BM449_10175	COG2264	protein methyltransferase activity
BM449_10180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BM449_10190	COG2302	S4 RNA-binding domain
BM449_10200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BM449_10230	COG0443	Heat shock 70 kDa protein
BM449_10245	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BM449_10250	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BM449_10265	COG0459	protein refolding
BM449_10270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BM449_10275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BM449_10280	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BM449_10295	COG0006	proline dipeptidase activity
BM449_10300	COG1253	flavin adenine dinucleotide binding
BM449_10305	COG1160	GTP binding
BM449_10310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BM449_10315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM449_10315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BM449_10320	COG0686	Belongs to the AlaDH PNT family
BM449_10325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM449_10335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BM449_10345	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BM449_10350	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BM449_10355	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BM449_10360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BM449_10370	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BM449_10375	COG0356	it plays a direct role in the translocation of protons across the membrane
BM449_10385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BM449_10410	COG0772	Belongs to the SEDS family
BM449_10420	COG1333	cytochrome c biogenesis protein
BM449_10425	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BM449_10440	COG0347	Belongs to the P(II) protein family
BM449_10450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BM449_10520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BM449_10525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BM449_10535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BM449_10540	COG2176	DNA-directed DNA polymerase activity
BM449_10545	COG0598	Magnesium transport protein CorA
BM449_10560	COG1732	Glycine betaine
BM449_10585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BM449_10595	COG1132	(ABC) transporter
BM449_10605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BM449_10610	COG0505	Belongs to the CarA family
BM449_10620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BM449_10635	COG0154	amidase activity
BM449_10640	COG0859	PFAM glycosyl transferase family 9
BM449_10640	COG0457	Tetratricopeptide repeat
BM449_10645	COG0587	DNA-directed DNA polymerase activity
BM449_10675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BM449_10680	COG0632	four-way junction helicase activity
BM449_10690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM449_10695	COG1129	ABC transporter
BM449_10695	COG0842	Transport permease protein
BM449_10700	COG0842	Transport permease protein
BM449_10740	COG0358	DNA primase activity
BM449_10755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BM449_10775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BM449_10785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BM449_10795	COG0022	dehydrogenase e1 component
BM449_10795	COG0508	dehydrogenase complex catalyzes the overall conversion of
BM449_10800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM449_10805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BM449_10820	COG0628	permease
BM449_10830	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BM449_10835	COG0515	serine threonine protein kinase
BM449_10855	COG2226	methyltransferase
BM449_10860	COG0174	glutamine synthetase
BM449_10870	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BM449_10890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BM449_10895	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BM449_10915	COG0612	Peptidase, M16
BM449_10925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BM449_10935	COG1136	(ABC) transporter
BM449_10940	COG1216	Glycosyl transferase, family 2
BM449_10945	COG0052	Belongs to the universal ribosomal protein uS2 family
BM449_10950	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BM449_10960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BM449_10965	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BM449_10975	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BM449_10980	COG0751	glycine-tRNA ligase activity
BM449_10985	COG0644	oxidoreductase
BM449_11020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BM449_11025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BM449_11030	COG1494	fructose-1,6-bisphosphatase
BM449_11035	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BM449_11040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BM449_11045	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BM449_11050	COG0363	glucosamine-6-phosphate deaminase activity
BM449_11065	COG0129	dihydroxy-acid dehydratase activity
BM449_11080	COG1845	cytochrome c oxidase, subunit III
BM449_11085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BM449_11110	COG0405	Gamma-glutamyltransferase
BM449_11120	COG1666	GTP binding
BM449_11130	COG0330	HflC and HflK could
BM449_11145	COG0857	belongs to the CobB CobQ family
BM449_11150	COG0300	oxidoreductase activity
BM449_11150	COG3000	fatty acid hydroxylase
BM449_11155	COG0024	Methionine aminopeptidase
BM449_11165	COG0335	large ribosomal subunit rRNA binding
BM449_11190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BM449_11200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM449_11200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BM449_11230	COG0489	protein tyrosine kinase activity
BM449_11260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BM449_11305	COG0438	transferase activity, transferring glycosyl groups
BM449_11315	COG0463	Glycosyl transferase, family 2
BM449_11325	COG0438	transferase activity, transferring glycosyl groups
BM449_11345	COG0438	transferase activity, transferring glycosyl groups
BM449_11370	COG1215	transferase activity, transferring glycosyl groups
BM449_11400	COG2801	Transposase and inactivated derivatives
BM449_11410	COG0438	transferase activity, transferring glycosyl groups
BM449_11420	COG1215	transferase activity, transferring glycosyl groups
BM449_11475	COG1132	(ABC) transporter
BM449_11570	COG0215	cysteine-tRNA ligase activity
BM449_11580	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BM449_11585	COG3411	Ferredoxin
BM449_11595	COG0702	epimerase
BM449_11610	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BM449_11625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM449_11640	COG2267	carboxylic ester hydrolase activity
BM449_11645	COG0440	acetolactate synthase activity
BM449_11650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM449_11680	COG0424	maF-like protein
BM449_11700	COG0482	sulfurtransferase activity
BM449_11705	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BM449_11705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BM449_11710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM449_11715	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BM449_11725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BM449_11735	COG1702	phosphate starvation-inducible protein PhoH
BM449_11740	COG0670	Belongs to the BI1 family
BM449_11745	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BM449_11750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BM449_11760	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BM449_11770	COG0336	Belongs to the RNA methyltransferase TrmD family
BM449_11775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BM449_11785	COG1691	(AIR) carboxylase
BM449_11805	COG0196	riboflavin kinase activity
BM449_11815	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BM449_11820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BM449_11825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BM449_11860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM449_11860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BM449_11865	COG0668	transmembrane transport
BM449_11880	COG0628	permease
BM449_11890	COG3239	Fatty acid desaturase
BM449_11910	COG2826	transposase and inactivated derivatives, IS30 family
BM449_11935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM449_11940	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BM449_11945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BM449_11960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BM449_11960	COG0574	Belongs to the PEP-utilizing enzyme family
BM449_11980	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
BM449_11985	COG3259	Nickel-dependent hydrogenase
BM449_11995	COG0375	protein maturation
BM449_12000	COG2345	Transcriptional regulator
BM449_12035	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BM449_12040	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BM449_12045	COG0298	carbon dioxide binding
BM449_12070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BM449_12075	COG0530	calcium, potassium:sodium antiporter activity
BM449_12080	COG0659	secondary active sulfate transmembrane transporter activity
BM449_12085	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BM449_12090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BM449_12095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BM449_12110	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BM449_12115	COG0347	Belongs to the P(II) protein family
BM449_12120	COG1126	abc transporter atp-binding protein
BM449_12125	COG0765	amino acid transport
BM449_12130	COG4597	amino acid ABC transporter
BM449_12135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BM449_12140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BM449_12145	COG0418	dihydroorotase activity
BM449_12155	COG2133	pyrroloquinoline quinone binding
BM449_12165	COG0010	Belongs to the arginase family
BM449_12170	COG0375	protein maturation
BM449_12185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BM449_12190	COG1116	anion transmembrane transporter activity
BM449_12205	COG2105	PFAM AIG2 family protein
BM449_12235	COG0811	peptide transport
BM449_12245	COG0644	oxidoreductase
BM449_12255	COG3424	synthase
BM449_12325	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BM449_12345	COG0412	Dienelactone hydrolase
BM449_12375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BM449_12380	COG0514	ATP-dependent DNA helicase (RecQ)
BM449_12390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BM449_12405	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BM449_12425	COG0740	serine-type endopeptidase activity
BM449_12435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BM449_12445	COG1136	(ABC) transporter
BM449_12445	COG0577	efflux transmembrane transporter activity
BM449_12450	COG0469	pyruvate kinase activity
BM449_12475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BM449_12480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BM449_12510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BM449_12515	COG0326	Molecular chaperone. Has ATPase activity
BM449_12520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BM449_12535	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BM449_12540	COG0483	inositol monophosphate 1-phosphatase activity
BM449_12555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BM449_12560	COG0581	inorganic phosphate transmembrane transporter activity
BM449_12565	COG0573	inorganic phosphate transmembrane transporter activity
BM449_12575	COG0484	heat shock protein binding
BM449_12585	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BM449_12590	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BM449_12595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BM449_12600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BM449_12600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BM449_12605	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BM449_12610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BM449_12635	COG0166	Belongs to the GPI family
BM449_12640	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BM449_12645	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BM449_12650	COG0495	leucyl-tRNA aminoacylation
BM449_12660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BM449_12690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BM449_12695	COG0426	domain, Protein
BM449_12695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BM449_12700	COG0322	excinuclease ABC activity
BM449_12725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BM449_12730	COG0646	methionine synthase
BM449_12730	COG1410	methionine synthase
BM449_12755	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BM449_12760	COG0384	phenazine biosynthesis protein PhzF
BM449_12765	COG2385	sporulation resulting in formation of a cellular spore
BM449_12775	COG1191	sigma factor activity
BM449_12790	COG0248	Ppx GppA phosphatase
BM449_12795	COG2963	transposase activity
BM449_12805	COG2801	Transposase and inactivated derivatives
BM449_12815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BM449_12820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM449_12820	COG0072	phenylalanine-tRNA ligase activity
BM449_12825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BM449_12830	COG0557	exoribonuclease II activity
BM449_12840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BM449_12870	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BM449_12895	COG0450	alkyl hydroperoxide reductase
BM449_12900	COG0047	phosphoribosylformylglycinamidine synthase activity
BM449_12905	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BM449_12925	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BM449_12930	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BM449_12935	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BM449_12940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BM449_12950	COG0297	glycogen (starch) synthase activity
BM449_12955	COG1376	ErfK ybiS ycfS ynhG family protein
BM449_12960	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BM449_12965	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BM449_12970	COG0681	Belongs to the peptidase S26 family
BM449_13010	COG0180	Tryptophanyl-tRNA synthetase
BM449_13025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BM449_13030	COG0837	glucose binding
BM449_13035	COG0083	homoserine kinase activity
BM449_13040	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BM449_13045	COG0339	signal peptide processing
BM449_13055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BM449_13060	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BM449_13065	COG1940	carbohydrate kinase activity
BM449_13100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BM449_13105	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BM449_13115	COG3794	PFAM blue (type 1) copper domain protein
BM449_13120	COG2010	Cytochrome c
BM449_13145	COG0542	response to heat
BM449_13155	COG0628	permease
BM449_13165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BM449_13190	COG0159	tryptophan synthase activity
BM449_13200	COG1064	alcohol dehydrogenase
BM449_13205	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BM449_13215	COG2010	Cytochrome c
BM449_13255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM449_13270	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BM449_13270	COG0140	phosphoribosyl-ATP diphosphatase activity
BM449_13280	COG0701	Predicted permease
BM449_13300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BM449_13305	COG1121	(ABC) transporter
BM449_13310	COG0803	Belongs to the bacterial solute-binding protein 9 family
BM449_13310	COG3443	Belongs to the bacterial solute-binding protein 9 family
BM449_13320	COG3128	pkhd-type hydroxylase
BM449_13325	COG3659	wide pore channel activity
BM449_13330	COG0310	cobalt ion transport
BM449_13335	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
BM449_13345	COG1122	ATPase activity
BM449_13355	COG0523	cobalamin synthesis protein
BM449_13365	COG1840	ABC-type Fe3 transport system, periplasmic component
BM449_13370	COG4176	ABC-type proline glycine betaine transport system permease component
BM449_13380	COG3415	Transposase
BM449_13380	COG2801	Transposase and inactivated derivatives
BM449_13405	COG0735	belongs to the Fur family
BM449_13415	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BM449_13440	COG0708	Exodeoxyribonuclease III
BM449_13445	COG0277	FAD linked oxidase domain protein
BM449_13450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BM449_13460	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BM449_13465	COG2045	Belongs to the ComB family
BM449_13470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BM449_13480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BM449_13485	COG0142	geranyltranstransferase activity
BM449_13495	COG2226	methyltransferase
BM449_13535	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BM449_13555	COG0181	hydroxymethylbilane synthase activity
BM449_13570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BM449_13575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BM449_13580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BM449_13590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BM449_13615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BM449_13620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BM449_13630	COG0442	prolyl-tRNA aminoacylation
BM449_13650	COG0681	Belongs to the peptidase S26 family
BM449_13660	COG0406	alpha-ribazole phosphatase activity
BM449_13680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BM449_13690	COG0644	oxidoreductase
BM449_13695	COG0233	cytoplasmic translational termination
BM449_13715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BM449_13720	COG0028	Belongs to the TPP enzyme family
BM449_13740	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BM449_13760	COG0539	negative regulation of cytoplasmic translation
BM449_13770	COG3396	Phenylacetate-CoA oxygenase
BM449_13775	COG5322	oxidoreductase activity
BM449_13780	COG0825	malonyl-CoA metabolic process
BM449_13785	COG4221	oxidoreductase activity
BM449_13790	COG0302	gtp cyclohydrolase
BM449_13800	COG0135	phosphoribosylanthranilate isomerase activity
BM449_13805	COG1994	Peptidase M50
BM449_13805	COG0517	IMP dehydrogenase activity
BM449_13810	COG0095	Lipoate-protein ligase
BM449_13850	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BM449_13855	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BM449_13860	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BM449_13870	COG1850	ribulose-bisphosphate carboxylase activity
BM449_13875	COG4451	ribulose bisphosphate carboxylase, small
BM449_13915	COG0464	growth