locus-tag	class	description
M744_00005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M744_00010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M744_00015	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M744_00020	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
M744_00025	COG0429	hydrolase of the alpha beta-hydrolase fold
M744_00055	COG2022	thiamine diphosphate biosynthetic process
M744_00085	COG2211	Major facilitator Superfamily
M744_00090	COG0587	DNA-directed DNA polymerase activity
M744_00095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M744_00100	COG0402	S-adenosylhomocysteine deaminase activity
M744_00105	COG0277	FAD linked oxidase domain protein
M744_00120	COG1136	(ABC) transporter
M744_00125	COG0556	nucleotide-excision repair
M744_00140	COG1122	ATPase activity
M744_00145	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M744_00160	COG0745	RESPONSE REGULATOR receiver
M744_00170	COG0012	GTP binding
M744_00175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M744_00200	COG0861	Integral membrane protein TerC family
M744_00215	COG0475	glutathione-regulated potassium exporter activity
M744_00235	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M744_00260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M744_00265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M744_00270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M744_00275	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M744_00280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M744_00305	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M744_00310	COG0363	glucosamine-6-phosphate deaminase activity
M744_00325	COG1175	transmembrane transport
M744_00330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M744_00370	COG0628	permease
M744_00375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M744_00375	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M744_00380	COG0793	Belongs to the peptidase S41A family
M744_00405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M744_00420	COG0644	oxidoreductase
M744_00425	COG0233	cytoplasmic translational termination
M744_00430	COG0528	UMP kinase activity
M744_00435	COG1494	fructose-1,6-bisphosphatase
M744_00440	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M744_00455	COG0702	epimerase
M744_00470	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M744_00500	COG0196	riboflavin kinase activity
M744_00510	COG3300	MHYT domain
M744_00510	COG5001	Diguanylate cyclase
M744_00515	COG1012	belongs to the aldehyde dehydrogenase family
M744_00520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M744_00530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M744_00535	COG0406	alpha-ribazole phosphatase activity
M744_00550	COG0768	penicillin binding
M744_00555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M744_00565	COG0481	GTPase activity
M744_00570	COG0681	Belongs to the peptidase S26 family
M744_00575	COG0762	integral membrane protein
M744_00580	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M744_00595	COG1902	pentaerythritol trinitrate reductase activity
M744_00600	COG1722	exodeoxyribonuclease VII activity
M744_00605	COG0395	ABC-type sugar transport system, permease component
M744_00620	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M744_00645	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M744_00650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M744_00665	COG0456	acetyltransferase
M744_00670	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M744_00690	COG0343	queuine tRNA-ribosyltransferase activity
M744_00695	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M744_00700	COG2205	protein histidine kinase activity
M744_00715	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M744_00720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M744_00725	COG0750	zinc metalloprotease
M744_00730	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M744_00735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M744_00740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M744_00755	COG0004	ammonium transporteR
M744_00760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M744_00765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M744_00770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M744_00785	COG1403	HNH endonuclease
M744_00795	COG0701	Predicted permease
M744_00810	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
M744_00820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M744_00830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M744_00835	COG1131	(ABC) transporter
M744_00865	COG3788	relative of glutathione S-transferase, MAPEG superfamily
M744_00875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M744_00920	COG0159	tryptophan synthase activity
M744_00935	COG0135	phosphoribosylanthranilate isomerase activity
M744_00960	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M744_00970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M744_00975	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M744_01000	COG0138	bifunctional purine biosynthesis protein purh
M744_01010	COG0575	Belongs to the CDS family
M744_01020	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M744_01040	COG0438	transferase activity, transferring glycosyl groups
M744_01045	COG0802	atpase or kinase
M744_01050	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M744_01055	COG0644	oxidoreductase
M744_01095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M744_01105	COG0612	Peptidase, M16
M744_01110	COG0612	Peptidase, M16
M744_01120	COG2850	peptidyl-arginine hydroxylation
M744_01130	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M744_01140	COG1231	oxidoreductase activity
M744_01145	COG1570	exodeoxyribonuclease VII activity
M744_01155	COG0385	Bile acid
M744_01205	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M744_01210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M744_01235	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M744_01240	COG1472	Belongs to the glycosyl hydrolase 3 family
M744_01250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M744_01260	COG1127	ABC transporter
M744_01270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M744_01285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M744_01285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M744_01315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M744_01325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M744_01330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M744_01335	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M744_01340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M744_01345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M744_01355	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M744_01360	COG0356	it plays a direct role in the translocation of protons across the membrane
M744_01370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M744_01375	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M744_01395	COG0772	Belongs to the SEDS family
M744_01400	COG4232	protein-disulfide reductase activity
M744_01405	COG1333	cytochrome c biogenesis protein
M744_01410	COG0347	Belongs to the P(II) protein family
M744_01415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M744_01420	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M744_01440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M744_01455	COG0792	nuclease activity
M744_01460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M744_01465	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M744_01470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M744_01480	COG0475	glutathione-regulated potassium exporter activity
M744_01480	COG0589	response to stress
M744_01505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M744_01510	COG0629	single-stranded DNA binding
M744_01515	COG1077	Cell shape determining protein MreB Mrl
M744_01520	COG1792	Involved in formation and maintenance of cell shape
M744_01530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M744_01540	COG2046	Belongs to the sulfate adenylyltransferase family
M744_01555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M744_01560	COG3536	Protein conserved in bacteria
M744_01570	COG0167	dihydroorotate dehydrogenase activity
M744_01575	COG0653	protein targeting
M744_01580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M744_01585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M744_01595	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
M744_01600	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
M744_01605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M744_01610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M744_01615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M744_01620	COG1058	Belongs to the CinA family
M744_01620	COG1546	Belongs to the CinA family
M744_01635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M744_01640	COG0277	FAD linked oxidase domain protein
M744_01645	COG2361	Protein of unknown function DUF86
M744_01655	COG0237	dephospho-CoA kinase activity
M744_01660	COG1587	Uroporphyrinogen-III synthase
M744_01665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M744_01670	COG0457	Tetratricopeptide repeat
M744_01670	COG0463	Glycosyl transferase, family 2
M744_01685	COG0357	Ribosomal RNA small subunit methyltransferase G
M744_01695	COG0484	heat shock protein binding
M744_01705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M744_01710	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M744_01715	COG0019	diaminopimelate decarboxylase activity
M744_01720	COG0456	acetyltransferase
M744_01725	COG0542	response to heat
M744_01740	COG1836	PFAM Integral membrane protein DUF92
M744_01745	COG1473	amidohydrolase
M744_01755	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M744_01780	COG1126	abc transporter atp-binding protein
M744_01785	COG0765	amino acid transport
M744_01790	COG4597	amino acid ABC transporter
M744_01795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M744_01805	COG0058	SHG alpha-glucan phosphorylase activity
M744_01810	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M744_01825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M744_01855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M744_01875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M744_01900	COG0193	aminoacyl-tRNA hydrolase activity
M744_01905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M744_01930	COG0837	glucose binding
M744_01945	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
M744_01960	COG0546	phosphoglycolate phosphatase activity
M744_01990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M744_02000	COG1492	cobalamin metabolic process
M744_02010	COG0424	maF-like protein
M744_02030	COG1051	belongs to the nudix hydrolase family
M744_02030	COG1056	cytidyltransferase-related domain
M744_02040	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M744_02040	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M744_02045	COG3278	Belongs to the heme-copper respiratory oxidase family
M744_02070	COG2211	Major facilitator Superfamily
M744_02075	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
M744_02085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M744_02085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M744_02105	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
M744_02110	COG0519	Catalyzes the synthesis of GMP from XMP
M744_02110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M744_02115	COG1366	Belongs to the anti-sigma-factor antagonist family
M744_02120	COG1253	flavin adenine dinucleotide binding
M744_02130	COG0405	Gamma-glutamyltransferase
M744_02135	COG0306	phosphate transporter
M744_02160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M744_02185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M744_02240	COG0799	negative regulation of ribosome biogenesis
M744_02260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M744_02280	COG0033	Phosphoglucomutase
M744_02300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M744_02310	COG0463	Glycosyl transferase, family 2
M744_02315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M744_02350	COG0022	dehydrogenase e1 component
M744_02350	COG0508	dehydrogenase complex catalyzes the overall conversion of
M744_02355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M744_02360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M744_02370	COG0028	Belongs to the TPP enzyme family
M744_02380	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M744_02385	COG0582	viral genome integration into host DNA
M744_02390	COG2226	methyltransferase
M744_02425	COG4372	Transposase
M744_02430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M744_02435	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M744_02440	COG0131	Imidazoleglycerol-phosphate dehydratase
M744_02460	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M744_02475	COG0590	tRNA wobble adenosine to inosine editing
M744_02485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M744_02515	COG0415	Belongs to the DNA photolyase family
M744_02520	COG0443	Heat shock 70 kDa protein
M744_02530	COG0783	Belongs to the Dps family
M744_02540	COG1160	GTP binding
M744_02545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M744_02550	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M744_02550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M744_02570	COG1252	NADH dehydrogenase
M744_02585	COG0469	pyruvate kinase activity
M744_02605	COG0745	RESPONSE REGULATOR receiver
M744_02610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M744_02615	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M744_02630	COG1725	Transcriptional regulator
M744_02635	COG0412	Dienelactone hydrolase
M744_02680	COG1132	(ABC) transporter
M744_02685	COG2501	S4 domain
M744_02690	COG1136	(ABC) transporter
M744_02690	COG0577	efflux transmembrane transporter activity
M744_02695	COG0629	single-stranded DNA binding
M744_02700	COG0432	Pfam Uncharacterised protein family UPF0047
M744_02715	COG0006	proline dipeptidase activity
M744_02730	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M744_02755	COG1131	(ABC) transporter
M744_02770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M744_02790	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M744_02810	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M744_02850	COG1216	Glycosyl transferase, family 2
M744_02855	COG4969	Belongs to the N-Me-Phe pilin family
M744_02860	COG4969	Belongs to the N-Me-Phe pilin family
M744_02870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M744_02890	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M744_02895	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M744_02900	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M744_02905	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M744_02910	COG1051	belongs to the nudix hydrolase family
M744_02935	COG2361	Protein of unknown function DUF86
M744_02940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M744_02945	COG4106	trans-aconitate 2-methyltransferase activity
M744_02945	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M744_02950	COG4106	trans-aconitate 2-methyltransferase activity
M744_02960	COG0156	8-amino-7-oxononanoate synthase activity
M744_03000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M744_03005	COG0751	glycine-tRNA ligase activity
M744_03010	COG0800	Aldolase
M744_03025	COG3128	pkhd-type hydroxylase
M744_03045	COG0360	Binds together with S18 to 16S ribosomal RNA
M744_03055	COG0586	Pfam SNARE associated Golgi protein
M744_03060	COG0137	argininosuccinate synthase activity
M744_03085	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M744_03090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M744_03100	COG0592	DNA-directed DNA polymerase activity
M744_03105	COG0546	phosphoglycolate phosphatase activity
M744_03110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M744_03120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M744_03140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M744_03150	COG1845	cytochrome c oxidase, subunit III
M744_03160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M744_03165	COG1612	heme a metabolic process
M744_03170	COG0109	protoheme IX farnesyltransferase activity
M744_03190	COG0673	inositol 2-dehydrogenase activity
M744_03195	COG1253	flavin adenine dinucleotide binding
M744_03215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M744_03230	COG2045	Belongs to the ComB family
M744_03235	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M744_03250	COG1959	2 iron, 2 sulfur cluster binding
M744_03255	COG1028	Short-chain dehydrogenase reductase Sdr
M744_03265	COG0483	inositol monophosphate 1-phosphatase activity
M744_03270	COG0633	Ferredoxin
M744_03280	COG0443	Heat shock 70 kDa protein
M744_03285	COG0484	heat shock protein binding
M744_03295	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M744_03330	COG0803	Belongs to the bacterial solute-binding protein 9 family
M744_03335	COG1121	(ABC) transporter
M744_03340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M744_03350	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M744_03355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M744_03360	COG0284	orotidine-5'-phosphate decarboxylase activity
M744_03370	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M744_03375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M744_03380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M744_03385	COG0511	ligase activity, forming carbon-carbon bonds
M744_03390	COG0419	ATPase involved in DNA repair
M744_03395	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M744_03410	COG0359	binds to the 23S rRNA
M744_03415	COG1104	cysteine desulfurase activity
M744_03425	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
M744_03430	COG3259	Nickel-dependent hydrogenase
M744_03440	COG0375	protein maturation
M744_03445	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M744_03450	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
M744_03455	COG0298	carbon dioxide binding
M744_03470	COG0066	3-isopropylmalate dehydratase activity
M744_03485	COG0436	Aminotransferase
M744_03495	COG1573	uracil-dna glycosylase
M744_03500	COG2010	Cytochrome c
M744_03515	COG0335	large ribosomal subunit rRNA binding
M744_03525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M744_03530	COG0740	serine-type endopeptidase activity
M744_03535	COG0740	serine-type endopeptidase activity
M744_03540	COG0484	heat shock protein binding
M744_03545	COG0745	RESPONSE REGULATOR receiver
M744_03545	COG3706	GGDEF domain
M744_03550	COG4251	negative regulation of phosphorylation
M744_03550	COG2203	Gaf domain
M744_03550	COG5001	Diguanylate cyclase
M744_03550	COG3706	GGDEF domain
M744_03565	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M744_03570	COG0052	Belongs to the universal ribosomal protein uS2 family
M744_03585	COG2267	carboxylic ester hydrolase activity
M744_03590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M744_03595	COG0740	serine-type endopeptidase activity
M744_03600	COG0544	peptidyl-prolyl cis-trans isomerase activity
M744_03610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M744_03615	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M744_03630	COG0297	glycogen (starch) synthase activity
M744_03655	COG1074	ATP-dependent DNA helicase activity
M744_03660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M744_03665	COG0434	BtpA family
M744_03675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M744_03685	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M744_03695	COG1252	NADH dehydrogenase
M744_03705	COG0175	sulfate reduction
M744_03730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M744_03740	COG2268	Band 7 protein
M744_03750	COG0105	UTP biosynthetic process
M744_03760	COG0559	Belongs to the binding-protein-dependent transport system permease family
M744_03770	COG0411	ABC transporter
M744_03785	COG0187	DNA topoisomerase II activity
M744_03785	COG1372	Participates in initiation and elongation during chromosome replication
M744_03790	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M744_03825	COG3751	2OG-Fe(II) oxygenase superfamily
M744_03835	COG1090	epimerase
M744_03845	COG0165	Argininosuccinate lyase
M744_03855	COG2208	phosphoserine phosphatase activity
M744_03860	COG0552	protein localization to endoplasmic reticulum
M744_03865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M744_03880	COG0443	Heat shock 70 kDa protein
M744_03890	COG0745	RESPONSE REGULATOR receiver
M744_03905	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
M744_03910	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M744_03915	COG1070	Carbohydrate kinase
M744_03920	COG2957	Belongs to the agmatine deiminase family
M744_03945	COG0752	glycyl-tRNA synthetase alpha subunit
M744_03965	COG0601	transmembrane transport
M744_03995	COG0450	alkyl hydroperoxide reductase
M744_04010	COG0024	Methionine aminopeptidase
M744_04015	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M744_04020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M744_04025	COG0573	inorganic phosphate transmembrane transporter activity
M744_04030	COG0581	inorganic phosphate transmembrane transporter activity
M744_04035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M744_04040	COG1185	polyribonucleotide nucleotidyltransferase activity
M744_04060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M744_04065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M744_04075	COG0440	acetolactate synthase activity
M744_04080	COG1073	alpha beta
M744_04080	COG2226	methyltransferase
M744_04085	COG4636	protein conserved in cyanobacteria
M744_04100	COG0811	peptide transport
M744_04105	COG0848	biopolymer transport protein
M744_04130	COG0445	tRNA wobble uridine modification
M744_04140	COG0672	)-iron permease
M744_04145	COG1045	serine acetyltransferase
M744_04155	COG0583	DNA-binding transcription factor activity
M744_04170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M744_04180	COG2226	methyltransferase
M744_04185	COG0330	HflC and HflK could
M744_04200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M744_04215	COG2022	thiamine diphosphate biosynthetic process
M744_04215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M744_04220	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M744_04250	COG2957	Belongs to the agmatine deiminase family
M744_04255	COG0071	Belongs to the small heat shock protein (HSP20) family
M744_04270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M744_04295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M744_04320	COG2140	Oxalate decarboxylase
M744_04335	COG0167	dihydroorotate dehydrogenase activity
M744_04340	COG0674	pyruvate-flavodoxin oxidoreductase activity
M744_04340	COG1013	pyruvate-flavodoxin oxidoreductase activity
M744_04340	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M744_04340	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M744_04345	COG4956	integral membrane protein (PIN domain superfamily)
M744_04350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M744_04355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M744_04365	COG0351	phosphomethylpyrimidine kinase
M744_04370	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M744_04385	COG1181	Belongs to the D-alanine--D-alanine ligase family
M744_04390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M744_04395	COG4948	Mandelate Racemase Muconate Lactonizing
M744_04440	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M744_04455	COG0142	geranyltranstransferase activity
M744_04470	COG0475	glutathione-regulated potassium exporter activity
M744_04475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M744_04485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M744_04500	COG0321	lipoyl(octanoyl) transferase activity
M744_04505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M744_04510	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
M744_04515	COG0009	L-threonylcarbamoyladenylate synthase
M744_04525	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M744_04565	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M744_04570	COG1160	GTP binding
M744_04600	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M744_04605	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M744_04610	COG3409	Peptidoglycan-binding domain 1 protein
M744_04610	COG3429	Glucose-6-phosphate dehydrogenase subunit
M744_04615	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M744_04625	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M744_04630	COG0793	Belongs to the peptidase S41A family
M744_04635	COG1078	dGTPase activity
M744_04660	COG0189	ligase activity
M744_04665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M744_04680	COG0457	Tetratricopeptide repeat
M744_04695	COG3093	addiction module antidote protein HigA
M744_04700	COG3224	Antibiotic biosynthesis monooxygenase
M744_04705	COG2217	Heavy metal translocating P-type atpase
M744_04710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M744_04715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M744_04720	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M744_04725	COG0459	protein refolding
M744_04730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M744_04750	COG0076	glutamate decarboxylase activity
M744_04755	COG0450	alkyl hydroperoxide reductase
M744_04760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M744_04770	COG0484	heat shock protein binding
M744_04775	COG0745	RESPONSE REGULATOR receiver
M744_04780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M744_04785	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M744_04805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M744_04810	COG0632	four-way junction helicase activity
M744_04815	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M744_04850	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M744_04855	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M744_04860	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M744_04875	COG0371	Dehydrogenase
M744_04880	COG2267	carboxylic ester hydrolase activity
M744_04885	COG1811	Na channel or pump
M744_04890	COG5002	protein histidine kinase activity
M744_04905	COG0004	ammonium transporteR
M744_04945	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
M744_04945	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
M744_04955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M744_04975	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M744_04990	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M744_05000	COG0124	histidyl-tRNA synthetase
M744_05025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M744_05030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M744_05055	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
M744_05060	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M744_05075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M744_05085	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M744_05090	COG0776	regulation of translation
M744_05100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M744_05115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M744_05125	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M744_05135	COG0456	acetyltransferase
M744_05150	COG0477	Major facilitator Superfamily
M744_05160	COG4172	Belongs to the ABC transporter superfamily
M744_05165	COG0336	Belongs to the RNA methyltransferase TrmD family
M744_05180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M744_05185	COG0088	Forms part of the polypeptide exit tunnel
M744_05190	COG0089	rRNA binding
M744_05195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M744_05200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M744_05205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M744_05210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M744_05215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M744_05220	COG0255	Belongs to the universal ribosomal protein uL29 family
M744_05225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M744_05230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M744_05235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M744_05240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M744_05245	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M744_05250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M744_05255	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M744_05260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M744_05265	COG0200	Binds to the 23S rRNA
M744_05270	COG0201	protein transport
M744_05275	COG0563	adenylate kinase activity
M744_05285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M744_05290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M744_05295	COG0202	RNA polymerase activity
M744_05300	COG0203	ribosomal protein L17
M744_05305	COG0101	tRNA pseudouridine synthase activity
M744_05310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M744_05315	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M744_05320	COG0254	rRNA binding
M744_05325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M744_05335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M744_05350	COG0587	DNA-directed DNA polymerase activity
M744_05360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M744_05380	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M744_05395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M744_05425	COG0121	glutamine amidotransferase
M744_05430	COG0328	RNA-DNA hybrid ribonuclease activity
M744_05440	COG0517	IMP dehydrogenase activity
M744_05440	COG1994	Peptidase M50
M744_05445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M744_05450	COG1597	lipid kinase activity
M744_05450	COG1803	Methylglyoxal synthase
M744_05455	COG1950	PFAM Membrane protein of
M744_05470	COG1840	ABC-type Fe3 transport system, periplasmic component
M744_05475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M744_05495	COG0783	Belongs to the Dps family
M744_05500	COG0735	belongs to the Fur family
M744_05555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M744_05560	COG2267	carboxylic ester hydrolase activity
M744_05575	COG0174	glutamine synthetase
M744_05630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M744_05645	COG0133	tryptophan synthase activity
M744_05650	COG0023	Translation Initiation Factor
M744_05665	COG0625	glutathione transferase activity
M744_05685	COG1429	ligase activity, forming nitrogen-metal bonds
M744_05690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M744_05700	COG0860	N-Acetylmuramoyl-L-alanine amidase
M744_05710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M744_05735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M744_05755	COG0123	including yeast histone deacetylase and acetoin utilization protein
M744_05760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M744_05765	COG0505	Belongs to the CarA family
M744_05775	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M744_05780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M744_05790	COG0154	amidase activity
M744_05810	COG2205	protein histidine kinase activity
M744_05815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M744_05825	COG1940	carbohydrate kinase activity
M744_05830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M744_05835	COG1132	(ABC) transporter
M744_05845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M744_05850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M744_05855	COG1116	anion transmembrane transporter activity
M744_05860	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
M744_05900	COG4251	negative regulation of phosphorylation
M744_05900	COG5001	Diguanylate cyclase
M744_05900	COG3706	GGDEF domain
M744_05900	COG2203	Gaf domain
M744_05910	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M744_05920	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M744_05925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M744_05930	COG0460	homoserine dehydrogenase
M744_05935	COG4243	Vitamin k epoxide reductase
M744_05950	COG0107	imidazoleglycerol-phosphate synthase activity
M744_05965	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M744_05970	COG2095	MarC family integral membrane protein
M744_05975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M744_05990	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
M744_05995	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M744_06020	COG0484	heat shock protein binding
M744_06025	COG0443	Heat shock 70 kDa protein
M744_06030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M744_06035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M744_06055	COG2081	HI0933 family
M744_06060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M744_06070	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M744_06075	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M744_06080	COG0644	oxidoreductase
M744_06090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M744_06095	COG1799	cell septum assembly
M744_06100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M744_06105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M744_06120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M744_06150	COG2885	chlorophyll binding
M744_06155	COG2885	chlorophyll binding
M744_06160	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M744_06160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M744_06165	COG0509	glycine decarboxylation via glycine cleavage system
M744_06175	COG1196	nuclear chromosome segregation
M744_06185	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M744_06195	COG0728	peptidoglycan biosynthetic process
M744_06200	COG1489	DNA binding
M744_06230	COG1819	glycosyl
M744_06250	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M744_06260	COG0166	Belongs to the GPI family
M744_06265	COG0438	transferase activity, transferring glycosyl groups
M744_06270	COG1215	transferase activity, transferring glycosyl groups
M744_06290	COG0779	Required for maturation of 30S ribosomal subunits
M744_06295	COG0195	Participates in both transcription termination and antitermination
M744_06305	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M744_06335	COG0515	serine threonine protein kinase
M744_06350	COG2385	sporulation resulting in formation of a cellular spore
M744_06355	COG1234	tRNA 3'-trailer cleavage
M744_06360	COG2010	Cytochrome c
M744_06365	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M744_06370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M744_06370	COG0426	domain, Protein
M744_06375	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M744_06390	COG1595	DNA-templated transcription, initiation
M744_06410	COG0850	regulation of cytokinetic process
M744_06420	COG0724	RNA recognition motif
M744_06430	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M744_06440	COG0140	phosphoribosyl-ATP diphosphatase activity
M744_06440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M744_06445	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
M744_06450	COG0235	Class ii aldolase
M744_06455	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M744_06460	COG1970	mechanosensitive ion channel activity
M744_06465	COG2119	membrane
M744_06470	COG1230	cation diffusion facilitator family transporter
M744_06490	COG0612	Peptidase, M16
M744_06500	COG1562	ergosterol biosynthetic process
M744_06505	COG0493	'glutamate synthase
M744_06505	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
M744_06530	COG3118	belongs to the thioredoxin family
M744_06535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M744_06540	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M744_06560	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M744_06570	COG1473	amidohydrolase
M744_06585	COG1968	undecaprenyl-diphosphatase activity
M744_06600	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M744_06605	COG1619	proteins homologs of microcin C7 resistance protein MccF
M744_06615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M744_06625	COG0442	prolyl-tRNA aminoacylation
M744_06640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M744_06650	COG0504	CTP synthase activity
M744_06700	COG0322	excinuclease ABC activity
M744_06705	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M744_06715	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M744_06720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M744_06720	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M744_06730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M744_06735	COG0798	PFAM Bile acid sodium symporter
M744_06740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M744_06750	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M744_06760	COG1304	FMN binding
M744_06770	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M744_06780	COG1104	cysteine desulfurase activity
M744_06790	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M744_06800	COG0739	heme binding
M744_06810	COG1595	DNA-templated transcription, initiation
M744_06825	COG0495	leucyl-tRNA aminoacylation
M744_06840	COG0697	spore germination
M744_06845	COG0616	signal peptide processing
M744_06870	COG0704	Plays a role in the regulation of phosphate uptake
M744_06880	COG0557	exoribonuclease II activity
M744_06885	COG0163	prenyltransferase activity
M744_06900	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M744_06905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M744_06935	COG0717	Belongs to the dCTP deaminase family
M744_06945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M744_06955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M744_06970	COG0411	ABC transporter
M744_06990	COG1543	Belongs to the glycosyl hydrolase 57 family
M744_07005	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M744_07005	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M744_07010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M744_07015	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M744_07015	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M744_07020	COG0515	serine threonine protein kinase
M744_07025	COG1555	photosystem II stabilization
M744_07030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M744_07045	COG0714	Associated with various cellular activities
M744_07065	COG0312	modulator of DNA gyrase
M744_07070	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M744_07080	COG5002	protein histidine kinase activity
M744_07090	COG1566	PFAM secretion protein HlyD family protein
M744_07115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M744_07125	COG0009	L-threonylcarbamoyladenylate synthase
M744_07130	COG2890	protein-(glutamine-N5) methyltransferase activity
M744_07145	COG0745	RESPONSE REGULATOR receiver
M744_07160	COG5398	heme oxygenase
M744_07165	COG2084	Dehydrogenase
M744_07175	COG1797	cobyrinic acid a,c-diamide synthase activity
M744_07205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M744_07220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M744_07225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M744_07230	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M744_07240	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M744_07265	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M744_07280	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
M744_07305	COG1192	Involved in chromosome partitioning
M744_07310	COG0525	valine-tRNA ligase activity
M744_07315	COG0516	GMP reductase activity
M744_07320	COG3118	belongs to the thioredoxin family
M744_07325	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M744_07345	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M744_07350	COG0517	IMP dehydrogenase activity
M744_07350	COG0516	GMP reductase activity
M744_07370	COG0670	Belongs to the BI1 family
M744_07375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M744_07395	COG0745	RESPONSE REGULATOR receiver
M744_07400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M744_07415	COG5002	protein histidine kinase activity
M744_07415	COG3447	MASE1 domain protein
M744_07415	COG5001	Diguanylate cyclase
M744_07420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M744_07420	COG0426	domain, Protein
M744_07425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M744_07425	COG0426	domain, Protein
M744_07430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M744_07440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M744_07460	COG2197	response regulator
M744_07465	COG0596	Alpha beta hydrolase
M744_07500	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M744_07505	COG0436	Aminotransferase
M744_07510	COG3118	belongs to the thioredoxin family
M744_07515	COG0113	porphobilinogen synthase activity
M744_07520	COG2133	pyrroloquinoline quinone binding
M744_07525	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M744_07530	COG0484	heat shock protein binding
M744_07560	COG1615	UPF0182 protein
M744_07570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M744_07575	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M744_07580	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M744_07585	COG0497	DNA recombination
M744_07590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M744_07605	COG1702	phosphate starvation-inducible protein PhoH
M744_07610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M744_07620	COG0228	four-way junction DNA binding
M744_07625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M744_07645	COG1271	oxidase subunit
M744_07665	COG0483	inositol monophosphate 1-phosphatase activity
M744_07680	COG0686	Belongs to the AlaDH PNT family
M744_07685	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M744_07690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M744_07715	COG0456	acetyltransferase
M744_07750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M744_07760	COG0824	Thioesterase
M744_07765	COG0649	NAD binding
M744_07770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M744_07775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M744_07780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M744_07790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M744_07795	COG0719	Fe-S assembly protein
M744_07800	COG0396	ATPase activity
M744_07805	COG0719	Fe-S assembly protein
M744_07810	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
M744_07825	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M744_07835	COG2205	protein histidine kinase activity
M744_07850	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M744_07855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M744_07870	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M744_07895	COG0538	isocitrate dehydrogenase activity
M744_07900	COG0277	FAD linked oxidase domain protein
M744_07905	COG0247	lactate metabolic process
M744_07915	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M744_07920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M744_07945	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M744_07950	COG0339	signal peptide processing
M744_07975	COG0383	alpha-mannosidase activity
M744_07990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M744_07995	COG0534	Mate efflux family protein
M744_08000	COG1733	regulation of RNA biosynthetic process
M744_08010	COG1741	Belongs to the pirin family
M744_08020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M744_08030	COG1715	Restriction endonuclease
M744_08040	COG2897	thiosulfate sulfurtransferase activity
M744_08045	COG4208	sulfate ABC transporter
M744_08055	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M744_08060	COG4208	sulfate ABC transporter
M744_08065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M744_08070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M744_08075	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M744_08080	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M744_08085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M744_08100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M744_08100	COG2022	thiamine diphosphate biosynthetic process
M744_08130	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
M744_08140	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M744_08150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M744_08160	COG0673	inositol 2-dehydrogenase activity
M744_08175	COG0215	cysteine-tRNA ligase activity
M744_08185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M744_08190	COG0778	Nitroreductase
M744_08205	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M744_08220	COG0371	Dehydrogenase
M744_08235	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M744_08240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M744_08240	COG1773	rubredoxin
M744_08260	COG0571	ribonuclease III activity
M744_08270	COG5001	Diguanylate cyclase
M744_08270	COG3706	GGDEF domain
M744_08270	COG4251	negative regulation of phosphorylation
M744_08270	COG2203	Gaf domain
M744_08285	COG3688	RNA-binding protein containing a PIN domain
M744_08290	COG1122	ATPase activity
M744_08310	COG3659	wide pore channel activity
M744_08315	COG3659	wide pore channel activity
M744_08320	COG1959	2 iron, 2 sulfur cluster binding
M744_08325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M744_08330	COG0484	heat shock protein binding
M744_08360	COG1006	Multisubunit Na H antiporter MnhC subunit
M744_08370	COG0347	Belongs to the P(II) protein family
M744_08380	COG2010	Cytochrome c
M744_08390	COG0742	ribosomal rna small subunit methyltransferase
M744_08395	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M744_08410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M744_08420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M744_08425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M744_08435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M744_08440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M744_08445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M744_08445	COG1116	anion transmembrane transporter activity
M744_08450	COG1116	anion transmembrane transporter activity
M744_08460	COG3956	TIGRFAM MazG family protein
M744_08475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M744_08495	COG0633	Ferredoxin
M744_08500	COG2264	protein methyltransferase activity
M744_08505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M744_08525	COG0473	3-isopropylmalate dehydrogenase activity
M744_08540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M744_08550	COG0482	sulfurtransferase activity
M744_08555	COG1191	sigma factor activity
M744_08565	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
M744_08570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M744_08575	COG1187	pseudouridine synthase activity
M744_08590	COG5002	protein histidine kinase activity
M744_08600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M744_08605	COG0268	Binds directly to 16S ribosomal RNA
M744_08610	COG0084	hydrolase, TatD family'
M744_08615	COG0085	RNA polymerase activity
M744_08620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M744_08625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M744_08640	COG3604	Transcriptional regulator
M744_08660	COG0725	ABC transporter, periplasmic molybdate-binding protein
M744_08665	COG4149	molybdate abc transporter
M744_08700	COG0716	FMN binding
M744_08720	COG1487	ribonuclease activity
M744_08725	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
M744_08740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M744_08745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M744_08755	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M744_08760	COG0613	PHP domain protein
M744_08765	COG0740	serine-type endopeptidase activity
M744_08780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M744_08795	COG0110	maltose O-acetyltransferase activity
M744_08830	COG1397	ADP-ribosylglycohydrolase
M744_08870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M744_08895	COG2217	Heavy metal translocating P-type atpase
M744_08925	COG0038	chloride channel
M744_08930	COG0018	arginyl-trna synthetase
M744_08935	COG0805	protein transport
M744_08960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M744_08970	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M744_08985	COG5002	protein histidine kinase activity
M744_08995	COG0038	chloride channel
M744_09010	COG0539	negative regulation of cytoplasmic translation
M744_09020	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M744_09025	COG5322	oxidoreductase activity
M744_09030	COG0825	malonyl-CoA metabolic process
M744_09035	COG0300	oxidoreductase activity
M744_09040	COG0302	gtp cyclohydrolase
M744_09045	COG0384	phenazine biosynthesis protein PhzF
M744_09050	COG2385	sporulation resulting in formation of a cellular spore
M744_09065	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
M744_09090	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M744_09095	COG3659	wide pore channel activity
M744_09100	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M744_09100	COG0662	Cupin 2, conserved barrel domain protein
M744_09115	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M744_09125	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M744_09140	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M744_09145	COG0594	ribonuclease P activity
M744_09155	COG0706	membrane insertase activity
M744_09170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M744_09175	COG1032	radical SAM domain protein
M744_09185	COG0826	peptidase U32
M744_09225	COG2010	Cytochrome c
M744_09255	COG3659	wide pore channel activity
M744_09260	COG3487	Iron-regulated protein
M744_09275	COG1214	PFAM Peptidase M22, glycoprotease
M744_09290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M744_09295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M744_09300	COG0416	fatty acid biosynthetic process
M744_09305	COG0745	RESPONSE REGULATOR receiver
M744_09310	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M744_09320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M744_09325	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M744_09330	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M744_09335	COG0288	reversible hydration of carbon dioxide
M744_09355	COG0191	fructose-bisphosphate aldolase activity
M744_09375	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M744_09380	COG0083	homoserine kinase activity
M744_09385	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M744_09410	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M744_09420	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M744_09430	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M744_09430	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M744_09435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M744_09450	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M744_09455	COG4451	ribulose bisphosphate carboxylase, small
M744_09460	COG1850	ribulose-bisphosphate carboxylase activity
M744_09465	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
M744_09475	COG4451	ribulose bisphosphate carboxylase, small
M744_09475	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M744_09480	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
M744_09490	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
M744_09495	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
M744_09510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M744_09515	COG1007	ATP synthesis coupled electron transport
M744_09520	COG1136	(ABC) transporter
M744_09525	COG0730	response to heat
M744_09535	COG0095	Lipoate-protein ligase
M744_09545	COG1840	ABC-type Fe3 transport system, periplasmic component
M744_09550	COG4106	trans-aconitate 2-methyltransferase activity
M744_09555	COG1178	ABC-type Fe3 transport system permease component
M744_09560	COG3842	ATPase activity
M744_09575	COG0745	RESPONSE REGULATOR receiver
M744_09580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M744_09630	COG0123	including yeast histone deacetylase and acetoin utilization protein
M744_09635	COG0737	Belongs to the 5'-nucleotidase family
M744_09645	COG0537	adenosine 5'-monophosphoramidase activity
M744_09655	COG3338	carbonate dehydratase activity
M744_09660	COG1606	tRNA processing
M744_09665	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
M744_09680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M744_09690	COG0488	(ABC) transporter
M744_09700	COG0439	Biotin carboxylase
M744_09710	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M744_09715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M744_09735	COG0564	pseudouridine synthase activity
M744_09745	COG1410	methionine synthase
M744_09745	COG0646	methionine synthase
M744_09750	COG0598	Magnesium transport protein CorA
M744_09760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M744_09780	COG1575	Belongs to the MenA family. Type 1 subfamily
M744_09785	COG2095	MarC family integral membrane protein
M744_09815	COG1316	TRANSCRIPTIONal
M744_09820	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
M744_09825	COG4279	zinc finger
M744_09830	COG4251	negative regulation of phosphorylation
M744_09835	COG0784	Response regulator, receiver
M744_09855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M744_09860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M744_09880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M744_09885	COG0713	ATP synthesis coupled electron transport
M744_09890	COG0839	Belongs to the complex I subunit 6 family
M744_09895	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M744_09900	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M744_09910	COG0628	permease
M744_09915	COG0242	peptide deformylase activity
M744_09955	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M744_09960	COG0602	queuosine metabolic process
M744_09970	COG2226	methyltransferase
M744_09990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M744_09995	COG0305	Participates in initiation and elongation during chromosome replication
M744_09995	COG1372	Participates in initiation and elongation during chromosome replication
M744_09995	COG0305	Participates in initiation and elongation during chromosome replication
M744_09995	COG1372	Participates in initiation and elongation during chromosome replication
M744_10000	COG4581	dead DEAH box helicase
M744_10005	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M744_10025	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M744_10030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M744_10035	COG1121	(ABC) transporter
M744_10040	COG0803	Belongs to the bacterial solute-binding protein 9 family
M744_10045	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M744_10050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M744_10055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M744_10075	COG0583	DNA-binding transcription factor activity
M744_10080	COG0646	methionine synthase
M744_10080	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M744_10085	COG0180	Tryptophanyl-tRNA synthetase
M744_10115	COG0589	response to stress
M744_10120	COG0514	ATP-dependent DNA helicase (RecQ)
M744_10125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M744_10130	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
M744_10135	COG3706	GGDEF domain
M744_10155	COG0515	serine threonine protein kinase
M744_10155	COG1357	PFAM Pentapeptide repeats (8 copies)
M744_10160	COG0072	phenylalanine-tRNA ligase activity
M744_10165	COG0358	DNA primase activity
M744_10170	COG0640	Transcriptional regulator
M744_10180	COG0312	modulator of DNA gyrase
M744_10195	COG0303	'Molybdopterin
M744_10200	COG0315	cyclic pyranopterin monophosphate synthase activity
M744_10200	COG0521	Mo-molybdopterin cofactor biosynthetic process
M744_10210	COG0314	molybdopterin synthase activity
M744_10215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M744_10240	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M744_10245	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M744_10250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M744_10265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M744_10265	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M744_10280	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M744_10285	COG2239	Acts as a magnesium transporter
M744_10295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M744_10305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M744_10315	COG0025	NhaP-type Na H and K H
M744_10320	COG0116	Belongs to the methyltransferase superfamily
M744_10325	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
M744_10335	COG0501	Belongs to the peptidase M48B family
M744_10340	COG0003	Pfam Anion-transporting ATPase
M744_10350	COG0038	chloride channel
M744_10355	COG0625	glutathione transferase activity
M744_10360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M744_10375	COG0420	3'-5' exonuclease activity
M744_10380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M744_10430	COG0583	DNA-binding transcription factor activity
M744_10440	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M744_10445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M744_10450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M744_10455	COG1116	anion transmembrane transporter activity
M744_10455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M744_10460	COG1116	anion transmembrane transporter activity
M744_10465	COG0243	molybdopterin cofactor binding
M744_10480	COG0723	plastoquinol--plastocyanin reductase activity
M744_10485	COG0739	heme binding
M744_10490	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M744_10495	COG2875	Belongs to the precorrin methyltransferase family
M744_10515	COG0612	Peptidase, M16
M744_10525	COG1566	PFAM secretion protein HlyD family protein
M744_10535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M744_10545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M744_10550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M744_10560	COG4251	negative regulation of phosphorylation
M744_10565	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M744_10575	COG0386	Belongs to the glutathione peroxidase family
M744_10615	COG4115	mRNA cleavage
M744_10625	COG4974	Belongs to the 'phage' integrase family
M744_10645	COG1216	Glycosyl transferase, family 2
M744_10655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M744_10660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M744_10665	COG0134	indole-3-glycerol-phosphate synthase activity
M744_10680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M744_10695	COG0194	GDP metabolic process
M744_10700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M744_10705	COG0746	molybdenum cofactor guanylyltransferase activity
M744_10740	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M744_10745	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M744_10750	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M744_10760	COG4447	cellulose binding
M744_10785	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M744_10790	COG3046	protein related to deoxyribodipyrimidine photolyase
M744_10795	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M744_10805	COG1691	(AIR) carboxylase
M744_10860	COG5001	Diguanylate cyclase
M744_10865	COG1074	ATP-dependent DNA helicase activity
M744_10880	COG1116	anion transmembrane transporter activity
M744_10885	COG1160	GTP binding
M744_10890	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M744_10895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M744_10895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M744_10910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M744_10925	COG0271	Belongs to the BolA IbaG family
M744_10930	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M744_10950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M744_10970	COG0037	tRNA processing
M744_11000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M744_11030	COG0312	modulator of DNA gyrase
M744_11040	COG2198	Histidine kinase
M744_11040	COG0643	Histidine kinase
M744_11045	COG0557	exoribonuclease II activity
M744_11050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M744_11060	COG3266	domain, Protein
M744_11060	COG0515	serine threonine protein kinase
M744_11070	COG0398	Pfam SNARE associated Golgi protein
M744_11085	COG0126	phosphoglycerate kinase activity
M744_11090	COG0589	response to stress
M744_11100	COG0628	permease
M744_11105	COG0564	pseudouridine synthase activity
M744_11110	COG4991	sh3 domain protein
M744_11110	COG0515	serine threonine protein kinase
M744_11110	COG3064	Membrane
M744_11120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M744_11125	COG0776	regulation of translation
M744_11140	COG0489	protein tyrosine kinase activity
M744_11145	COG0772	Belongs to the SEDS family
M744_11150	COG0363	glucosamine-6-phosphate deaminase activity
M744_11160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M744_11165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M744_11170	COG2226	methyltransferase
M744_11175	COG4399	Belongs to the UPF0754 family
M744_11180	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M744_11195	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M744_11220	COG0542	response to heat
M744_11225	COG3794	PFAM blue (type 1) copper domain protein
M744_11235	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M744_11240	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M744_11250	COG1215	transferase activity, transferring glycosyl groups
M744_11255	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M744_11265	COG0569	domain protein
M744_11270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M744_11280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M744_11310	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M744_11335	COG0508	dehydrogenase complex catalyzes the overall conversion of
M744_11380	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M744_11395	COG0352	thiamine-phosphate diphosphorylase activity
M744_11405	COG1413	lyase activity
M744_11410	COG1413	lyase activity
M744_11425	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M744_11430	COG0237	dephospho-CoA kinase activity
M744_11435	COG0237	dephospho-CoA kinase activity
M744_11455	COG2385	sporulation resulting in formation of a cellular spore
M744_11465	COG0170	dolichyl monophosphate biosynthetic process
M744_11495	COG1166	arginine decarboxylase activity
M744_11525	COG2308	Evidence 4 Homologs of previously reported genes of
M744_11535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M744_11540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M744_11550	COG0596	Alpha beta hydrolase
M744_11555	COG2052	Domain of unknown function (DUF370)
M744_11565	COG0464	growth
M744_11580	COG0318	PFAM AMP-dependent synthetase and ligase
M744_11585	COG4948	Mandelate Racemase Muconate Lactonizing
M744_11590	COG1640	4-alpha-glucanotransferase
M744_11600	COG0217	transcriptional regulatory protein
M744_11615	COG0840	transmembrane signaling receptor activity
M744_11635	COG0745	RESPONSE REGULATOR receiver
M744_11640	COG5002	protein histidine kinase activity
M744_11645	COG1187	pseudouridine synthase activity
M744_11655	COG0788	formyltetrahydrofolate deformylase activity
M744_11660	COG0114	fumarate hydratase activity
M744_11675	COG1011	Hydrolase
M744_11685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M744_11710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M744_11715	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M744_11720	COG0572	uridine kinase
M744_11735	COG1160	GTP binding
M744_11765	COG0735	belongs to the Fur family
M744_11775	COG2814	Major facilitator Superfamily
M744_11780	COG1381	Involved in DNA repair and RecF pathway recombination
M744_11785	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M744_11805	COG1280	lysine exporter protein (LysE YggA)
M744_11820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M744_11825	COG0572	uridine kinase
M744_11830	COG0617	tRNA 3'-terminal CCA addition
M744_11835	COG0275	rRNA processing
M744_11845	COG0251	oxidation-reduction process
M744_11860	COG0412	Dienelactone hydrolase
M744_11870	COG0181	hydroxymethylbilane synthase activity
M744_11880	COG0483	inositol monophosphate 1-phosphatase activity
M744_11890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M744_11890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M744_11895	COG1316	TRANSCRIPTIONal
M744_11905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M744_11910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M744_11920	COG0523	cobalamin synthesis protein
M744_11930	COG0354	folic acid binding
M744_11945	COG0157	Belongs to the NadC ModD family
M744_11950	COG1653	transport
M744_11970	COG1231	oxidoreductase activity
M744_11985	COG0285	dihydrofolate synthase activity
M744_11990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M744_12000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M744_12005	COG0488	(ABC) transporter
M744_12020	COG0529	Catalyzes the synthesis of activated sulfate
M744_12030	COG3453	Protein conserved in bacteria
M744_12030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M744_12035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M744_12045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M744_12065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M744_12075	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M744_12080	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M744_12095	COG0151	Belongs to the GarS family
M744_12100	COG5002	protein histidine kinase activity
M744_12105	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M744_12110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M744_12130	COG1022	Amp-dependent synthetase and ligase
M744_12135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M744_12160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M744_12175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M744_12190	COG0316	Belongs to the HesB IscA family
M744_12215	COG1049	propionate catabolic process, 2-methylcitrate cycle
M744_12245	COG3411	Ferredoxin
M744_12250	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M744_12255	COG2894	cell division
M744_12265	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M744_12275	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
M744_12285	COG0070	glutamate synthase
M744_12285	COG0069	glutamate synthase activity
M744_12285	COG0067	glutamate synthase
M744_12300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M744_12305	COG0049	tRNA binding
M744_12310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M744_12315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M744_12320	COG0051	transcription antitermination factor activity, RNA binding
M744_12330	COG0077	Prephenate dehydratase
M744_12340	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M744_12345	COG1530	ribonuclease E activity
M744_12355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M744_12360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M744_12370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M744_12400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M744_12415	COG1666	GTP binding
M744_12425	COG0857	belongs to the CobB CobQ family
M744_12435	COG3000	fatty acid hydroxylase
M744_12435	COG0300	oxidoreductase activity
M744_12445	COG2198	Histidine kinase
M744_12445	COG0643	Histidine kinase
M744_12450	COG0840	transmembrane signaling receptor activity
M744_12450	COG2203	Gaf domain
M744_12465	COG0784	Response regulator, receiver
M744_12480	COG0436	Aminotransferase
M744_12485	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M744_12500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M744_12505	COG2805	Type II/IV secretion system protein
M744_12525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M744_12530	COG2072	flavoprotein involved in K transport
M744_12555	COG2144	transferase activity, transferring acyl groups
M744_12565	COG2255	four-way junction helicase activity
M744_12600	COG0017	Asparaginyl-tRNA synthetase
M744_12630	COG0392	lysyltransferase activity
M744_12630	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M744_12635	COG0628	permease
M744_12645	COG4166	transmembrane transport
M744_12655	COG0047	phosphoribosylformylglycinamidine synthase activity
M744_12660	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M744_12665	COG0735	belongs to the Fur family
M744_12670	COG3300	MHYT domain
M744_12670	COG5001	Diguanylate cyclase
M744_12680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M744_12685	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
M744_12690	COG0484	heat shock protein binding
M744_12710	COG0438	transferase activity, transferring glycosyl groups
M744_12720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M744_12745	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M744_12760	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M744_12780	COG1842	Phage shock protein A
M744_12810	COG0625	glutathione transferase activity
M744_12830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M744_12835	COG1132	(ABC) transporter
M744_12840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M744_12840	COG0574	Belongs to the PEP-utilizing enzyme family
M744_12845	COG1357	PFAM Pentapeptide repeats (8 copies)
M744_12845	COG0515	serine threonine protein kinase
M744_12850	COG1480	7TM receptor with intracellular HD hydrolase
M744_12860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M744_12865	COG0142	geranyltranstransferase activity
M744_12880	COG0454	-acetyltransferase
M744_13125	COG1061	Type III restriction enzyme res subunit
M744_13195	COG0582	viral genome integration into host DNA
M744_13220	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M744_13225	COG0793	Belongs to the peptidase S41A family
M744_13230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M744_13245	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M744_13250	COG1982	Orn Lys Arg decarboxylase major
M744_13275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M744_13275	COG0758	DNA mediated transformation
M744_13285	COG0824	Thioesterase
M744_13290	COG0589	response to stress
M744_13315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M744_13320	COG0539	negative regulation of cytoplasmic translation
M744_13340	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M744_13350	COG0640	Transcriptional regulator
M744_13360	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
M744_13370	COG0459	protein refolding
M744_13375	COG1028	Short-chain dehydrogenase reductase Sdr
M744_13380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M744_13390	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M744_13400	COG0724	RNA recognition motif
M744_13435	COG0408	coproporphyrinogen oxidase activity
M744_13450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M744_13460	COG0540	Belongs to the ATCase OTCase family
M744_13465	COG2094	Belongs to the DNA glycosylase MPG family
M744_13485	COG1402	creatininase
M744_13490	COG3264	Mechanosensitive ion channel
M744_13490	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M744_13510	COG0287	Prephenate dehydrogenase
M744_13545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M744_13555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M744_13565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M744_13575	COG1376	ErfK ybiS ycfS ynhG family protein
M744_13585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M744_13590	COG2205	protein histidine kinase activity
M744_13590	COG2202	Pas domain
M744_13615	COG1053	succinate dehydrogenase
M744_13620	COG1132	(ABC) transporter
M744_13630	COG0148	phosphopyruvate hydratase activity
M744_13635	COG0346	lactoylglutathione lyase activity
M744_13640	COG0542	response to heat
M744_13645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M744_13650	COG0250	Participates in transcription elongation, termination and antitermination
M744_13655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M744_13660	COG0081	regulation of translation
M744_13670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M744_13675	COG0222	ribosome binding
M744_13690	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M744_13710	COG0129	dihydroxy-acid dehydratase activity
M744_13715	COG3854	ATPases associated with a variety of cellular activities
M744_13725	COG0492	ferredoxin-NADP+ reductase activity
M744_13730	COG4178	(ABC) transporter
M744_13745	COG0586	Pfam SNARE associated Golgi protein
M744_13750	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M744_13760	COG1420	regulation of RNA biosynthetic process
M744_13775	COG2062	phosphohistidine phosphatase, SixA
M744_13780	COG0372	Belongs to the citrate synthase family
M744_13785	COG1193	negative regulation of DNA recombination
M744_13790	COG0668	transmembrane transport
M744_13795	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M744_13800	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M744_13810	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M744_13815	COG3781	membrane
M744_13820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M744_13825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M744_13840	COG0515	serine threonine protein kinase
M744_13870	COG2226	methyltransferase
M744_13890	COG0205	6-phosphofructokinase activity
M744_13895	COG2119	membrane
M744_13915	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M744_13920	COG0525	valine-tRNA ligase activity
M744_13990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M744_13995	COG1116	anion transmembrane transporter activity
M744_13995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M744_14025	COG2059	Chromate
M744_14030	COG1285	pathogenesis
M744_14035	COG0753	catalase activity
M744_14065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M744_14070	COG1045	serine acetyltransferase
M744_14075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M744_14080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M744_14085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M744_14100	COG2894	cell division
M744_14125	COG0582	viral genome integration into host DNA
M744_14150	COG0745	RESPONSE REGULATOR receiver
M744_14155	COG2205	protein histidine kinase activity