locus-tag	class	description
RNA_34	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynWH7803_0001	COG0592	DNA-directed DNA polymerase activity
SynWH7803_0003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynWH7803_0004	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynWH7803_0005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynWH7803_0007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynWH7803_0010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynWH7803_0011	COG0552	protein localization to endoplasmic reticulum
SynWH7803_0012	COG2208	phosphoserine phosphatase activity
SynWH7803_0013	COG0165	Argininosuccinate lyase
SynWH7803_0014	COG0724	RNA recognition motif
SynWH7803_0015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynWH7803_0017	COG2081	HI0933 family
SynWH7803_0021	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynWH7803_0022	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynWH7803_0023	COG0484	heat shock protein binding
SynWH7803_0025	COG1162	GTPase activity
SynWH7803_0026	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynWH7803_0027	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynWH7803_0028	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynWH7803_0029	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynWH7803_0030	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynWH7803_0031	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynWH7803_0032	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynWH7803_0033	COG0511	ligase activity, forming carbon-carbon bonds
SynWH7803_0034	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynWH7803_0047	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynWH7803_0048	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynWH7803_0048	COG0519	Catalyzes the synthesis of GMP from XMP
SynWH7803_0052	COG0438	transferase activity, transferring glycosyl groups
SynWH7803_0053	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynWH7803_0055	COG2022	thiamine diphosphate biosynthetic process
SynWH7803_0058	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynWH7803_0059	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynWH7803_0060	COG2385	sporulation resulting in formation of a cellular spore
SynWH7803_0061	COG1215	transferase activity, transferring glycosyl groups
SynWH7803_0062	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynWH7803_0064	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynWH7803_0065	COG3220	belongs to the UPF0276 family
SynWH7803_0067	COG1231	oxidoreductase activity
SynWH7803_0070	COG0740	serine-type endopeptidase activity
SynWH7803_0071	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynWH7803_0072	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynWH7803_0073	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynWH7803_0074	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynWH7803_0076	COG0037	tRNA processing
SynWH7803_0080	COG0556	nucleotide-excision repair
SynWH7803_0083	COG2082	Precorrin-8x methylmutase
SynWH7803_0084	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynWH7803_0088	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynWH7803_0092	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynWH7803_0105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SynWH7803_0110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynWH7803_0111	COG0737	Belongs to the 5'-nucleotidase family
SynWH7803_0113	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynWH7803_0114	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynWH7803_0115	COG0438	transferase activity, transferring glycosyl groups
SynWH7803_0141	COG0653	protein targeting
SynWH7803_0142	COG1045	serine acetyltransferase
SynWH7803_0143	COG1725	Transcriptional regulator
SynWH7803_0145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynWH7803_0146	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynWH7803_0147	COG0187	DNA topoisomerase II activity
SynWH7803_0147	COG1372	Participates in initiation and elongation during chromosome replication
SynWH7803_0149	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynWH7803_0150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynWH7803_0151	COG0386	Belongs to the glutathione peroxidase family
SynWH7803_0152	COG2239	Acts as a magnesium transporter
SynWH7803_0153	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH7803_0161	COG0477	Major facilitator Superfamily
SynWH7803_0166	COG1070	Carbohydrate kinase
SynWH7803_0168	COG0802	atpase or kinase
SynWH7803_0169	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynWH7803_0170	COG0586	Pfam SNARE associated Golgi protein
SynWH7803_0171	COG0629	single-stranded DNA binding
SynWH7803_0176	COG0745	RESPONSE REGULATOR receiver
SynWH7803_0177	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynWH7803_0181	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynWH7803_0182	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynWH7803_0183	COG0515	serine threonine protein kinase
SynWH7803_0183	COG1357	PFAM Pentapeptide repeats (8 copies)
SynWH7803_0184	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynWH7803_0185	COG2255	four-way junction helicase activity
SynWH7803_0187	COG1473	amidohydrolase
SynWH7803_0190	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynWH7803_0193	COG0463	Glycosyl transferase, family 2
SynWH7803_0195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynWH7803_0196	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynWH7803_0197	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynWH7803_0198	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH7803_0199	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynWH7803_0200	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SynWH7803_0200	COG0662	Cupin 2, conserved barrel domain protein
SynWH7803_0201	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynWH7803_0203	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynWH7803_0204	COG0571	ribonuclease III activity
SynWH7803_0207	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SynWH7803_0208	COG0058	SHG alpha-glucan phosphorylase activity
SynWH7803_0209	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SynWH7803_0210	COG0475	glutathione-regulated potassium exporter activity
SynWH7803_0214	COG0277	FAD linked oxidase domain protein
SynWH7803_0216	COG0247	lactate metabolic process
SynWH7803_0217	COG0538	isocitrate dehydrogenase activity
SynWH7803_0218	COG0463	Glycosyl transferase, family 2
SynWH7803_0221	COG5398	heme oxygenase
SynWH7803_0224	COG0438	transferase activity, transferring glycosyl groups
SynWH7803_0225	COG0438	transferase activity, transferring glycosyl groups
SynWH7803_0226	COG0438	transferase activity, transferring glycosyl groups
SynWH7803_0227	COG0438	transferase activity, transferring glycosyl groups
SynWH7803_0231	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynWH7803_0233	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynWH7803_0234	COG0617	tRNA 3'-terminal CCA addition
SynWH7803_0237	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynWH7803_0241	COG0709	Synthesizes selenophosphate from selenide and ATP
SynWH7803_0242	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynWH7803_0243	COG0124	histidyl-tRNA synthetase
SynWH7803_0244	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynWH7803_0250	COG4447	cellulose binding
SynWH7803_0252	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH7803_0253	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH7803_0254	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH7803_0255	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynWH7803_0256	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SynWH7803_0258	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynWH7803_0258	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynWH7803_0260	COG4988	ABC transporter
SynWH7803_0261	COG0494	nUDIX hydrolase
SynWH7803_0262	COG0415	Belongs to the DNA photolyase family
SynWH7803_0268	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynWH7803_0269	COG0131	Imidazoleglycerol-phosphate dehydratase
SynWH7803_0270	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynWH7803_0273	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynWH7803_0277	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynWH7803_0278	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynWH7803_0281	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SynWH7803_0283	COG1253	flavin adenine dinucleotide binding
SynWH7803_0284	COG0673	inositol 2-dehydrogenase activity
SynWH7803_0288	COG0343	queuine tRNA-ribosyltransferase activity
SynWH7803_0289	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SynWH7803_0293	COG0138	bifunctional purine biosynthesis protein purh
SynWH7803_0296	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynWH7803_0297	COG0004	ammonium transporteR
SynWH7803_0298	COG1489	DNA binding
SynWH7803_0299	COG0728	peptidoglycan biosynthetic process
SynWH7803_0303	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynWH7803_0304	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynWH7803_0305	COG1058	Belongs to the CinA family
SynWH7803_0305	COG1546	Belongs to the CinA family
SynWH7803_0306	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynWH7803_0307	COG0066	3-isopropylmalate dehydratase activity
SynWH7803_0314	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynWH7803_0315	COG0193	aminoacyl-tRNA hydrolase activity
SynWH7803_0318	COG4372	Transposase
SynWH7803_0320	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynWH7803_0322	COG0717	Belongs to the dCTP deaminase family
SynWH7803_0324	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynWH7803_0326	COG0741	lytic transglycosylase activity
SynWH7803_0328	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynWH7803_0331	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynWH7803_0335	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynWH7803_0338	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynWH7803_0341	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynWH7803_0343	COG2094	Belongs to the DNA glycosylase MPG family
SynWH7803_0344	COG0540	Belongs to the ATCase OTCase family
SynWH7803_0349	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynWH7803_0351	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynWH7803_0354	COG2046	Belongs to the sulfate adenylyltransferase family
SynWH7803_0354	COG0529	Catalyzes the synthesis of activated sulfate
SynWH7803_0355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynWH7803_0356	COG0800	Aldolase
SynWH7803_0358	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynWH7803_0360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynWH7803_0361	COG2226	methyltransferase
SynWH7803_0362	COG4175	Glycine betaine
SynWH7803_0363	COG4176	ABC-type proline glycine betaine transport system permease component
SynWH7803_0364	COG2113	Glycine betaine
SynWH7803_0365	COG0385	Bile acid
SynWH7803_0367	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynWH7803_0369	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynWH7803_0370	COG0436	Aminotransferase
SynWH7803_0372	COG1530	ribonuclease E activity
SynWH7803_0373	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynWH7803_0376	COG2226	methyltransferase
SynWH7803_0377	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynWH7803_0378	COG0051	transcription antitermination factor activity, RNA binding
SynWH7803_0379	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynWH7803_0380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynWH7803_0381	COG0049	tRNA binding
SynWH7803_0382	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynWH7803_0385	COG0067	glutamate synthase
SynWH7803_0385	COG0070	glutamate synthase
SynWH7803_0385	COG0069	glutamate synthase activity
SynWH7803_0387	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynWH7803_0391	COG2885	chlorophyll binding
SynWH7803_0392	COG2885	chlorophyll binding
SynWH7803_0399	COG0463	Glycosyl transferase, family 2
SynWH7803_0403	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynWH7803_0405	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynWH7803_0406	COG0254	rRNA binding
SynWH7803_0407	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynWH7803_0408	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynWH7803_0409	COG0101	tRNA pseudouridine synthase activity
SynWH7803_0410	COG0203	ribosomal protein L17
SynWH7803_0411	COG0202	RNA polymerase activity
SynWH7803_0412	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynWH7803_0413	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynWH7803_0414	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynWH7803_0415	COG0563	adenylate kinase activity
SynWH7803_0416	COG0201	protein transport
SynWH7803_0417	COG0200	Binds to the 23S rRNA
SynWH7803_0418	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynWH7803_0419	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynWH7803_0420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynWH7803_0421	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynWH7803_0422	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynWH7803_0423	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynWH7803_0424	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynWH7803_0425	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynWH7803_0426	COG0255	Belongs to the universal ribosomal protein uL29 family
SynWH7803_0427	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynWH7803_0428	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynWH7803_0429	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynWH7803_0430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynWH7803_0431	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynWH7803_0432	COG0089	rRNA binding
SynWH7803_0433	COG0088	Forms part of the polypeptide exit tunnel
SynWH7803_0434	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynWH7803_0437	COG3854	ATPases associated with a variety of cellular activities
SynWH7803_0439	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynWH7803_0443	COG0287	Prephenate dehydrogenase
SynWH7803_0449	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynWH7803_0450	COG1606	tRNA processing
SynWH7803_0451	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynWH7803_0452	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynWH7803_0454	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynWH7803_0455	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynWH7803_0456	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynWH7803_0459	COG0772	Belongs to the SEDS family
SynWH7803_0460	COG0489	protein tyrosine kinase activity
SynWH7803_0461	COG0408	coproporphyrinogen oxidase activity
SynWH7803_0470	COG0667	Aldo Keto reductase
SynWH7803_0472	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynWH7803_0473	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynWH7803_0474	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynWH7803_0474	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynWH7803_0475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynWH7803_0487	COG0237	dephospho-CoA kinase activity
SynWH7803_0501	COG0237	dephospho-CoA kinase activity
SynWH7803_0505	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynWH7803_0512	COG1070	Carbohydrate kinase
SynWH7803_0513	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynWH7803_0514	COG0546	phosphoglycolate phosphatase activity
SynWH7803_0515	COG0539	negative regulation of cytoplasmic translation
SynWH7803_0516	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynWH7803_0521	COG0589	response to stress
SynWH7803_0524	COG2890	protein-(glutamine-N5) methyltransferase activity
SynWH7803_0525	COG0009	L-threonylcarbamoyladenylate synthase
SynWH7803_0528	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynWH7803_0529	COG2894	cell division
SynWH7803_0530	COG0850	regulation of cytokinetic process
SynWH7803_0531	COG1078	dGTPase activity
SynWH7803_0532	COG0793	Belongs to the peptidase S41A family
SynWH7803_0533	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynWH7803_0534	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynWH7803_0535	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SynWH7803_0537	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynWH7803_0539	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynWH7803_0542	COG0514	ATP-dependent DNA helicase (RecQ)
SynWH7803_0543	COG1388	LysM domain
SynWH7803_0543	COG1705	Flagellar rod assembly protein muramidase FlgJ
SynWH7803_0544	COG1012	belongs to the aldehyde dehydrogenase family
SynWH7803_0546	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynWH7803_0547	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SynWH7803_0549	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynWH7803_0556	COG2274	protein secretion by the type I secretion system
SynWH7803_0557	COG2274	protein secretion by the type I secretion system
SynWH7803_0560	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynWH7803_0564	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynWH7803_0568	COG1160	GTP binding
SynWH7803_0569	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynWH7803_0571	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynWH7803_0572	COG1799	cell septum assembly
SynWH7803_0573	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynWH7803_0574	COG0438	transferase activity, transferring glycosyl groups
SynWH7803_0576	COG1381	Involved in DNA repair and RecF pathway recombination
SynWH7803_0578	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynWH7803_0579	COG0321	lipoyl(octanoyl) transferase activity
SynWH7803_0580	COG1022	Amp-dependent synthetase and ligase
SynWH7803_0583	COG0531	amino acid
SynWH7803_0584	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynWH7803_0585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynWH7803_0589	COG3239	Fatty acid desaturase
SynWH7803_0591	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynWH7803_0594	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynWH7803_0596	COG1104	cysteine desulfurase activity
SynWH7803_0601	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynWH7803_0602	COG0579	oxidoreductase
SynWH7803_0605	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynWH7803_0608	COG2095	MarC family integral membrane protein
SynWH7803_0609	COG0181	hydroxymethylbilane synthase activity
SynWH7803_0611	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH7803_0612	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynWH7803_0614	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynWH7803_0617	COG0629	single-stranded DNA binding
SynWH7803_0619	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynWH7803_0620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynWH7803_0622	COG0442	prolyl-tRNA aminoacylation
SynWH7803_0624	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynWH7803_0628	COG0681	Belongs to the peptidase S26 family
SynWH7803_0629	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SynWH7803_0633	COG0768	penicillin binding
SynWH7803_0634	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynWH7803_0636	COG0415	Belongs to the DNA photolyase family
SynWH7803_0638	COG0233	cytoplasmic translational termination
SynWH7803_0639	COG0528	UMP kinase activity
SynWH7803_0644	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynWH7803_0645	COG0028	Belongs to the TPP enzyme family
SynWH7803_0649	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynWH7803_0652	COG0539	negative regulation of cytoplasmic translation
SynWH7803_0654	COG3396	Phenylacetate-CoA oxygenase
SynWH7803_0655	COG5322	oxidoreductase activity
SynWH7803_0656	COG0825	malonyl-CoA metabolic process
SynWH7803_0658	COG0302	gtp cyclohydrolase
SynWH7803_0660	COG0135	phosphoribosylanthranilate isomerase activity
SynWH7803_0661	COG1994	Peptidase M50
SynWH7803_0661	COG0517	IMP dehydrogenase activity
SynWH7803_0662	COG0095	Lipoate-protein ligase
SynWH7803_0663	COG0730	response to heat
SynWH7803_0670	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynWH7803_0671	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynWH7803_0672	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynWH7803_0676	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynWH7803_0678	COG1850	ribulose-bisphosphate carboxylase activity
SynWH7803_0679	COG4451	ribulose bisphosphate carboxylase, small
SynWH7803_0685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynWH7803_0686	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH7803_0692	COG0251	oxidation-reduction process
SynWH7803_0694	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynWH7803_0695	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynWH7803_0696	COG1132	(ABC) transporter
SynWH7803_0697	COG2267	carboxylic ester hydrolase activity
SynWH7803_0698	COG0456	acetyltransferase
SynWH7803_0701	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynWH7803_0702	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynWH7803_0706	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynWH7803_0707	COG0811	peptide transport
SynWH7803_0713	COG1845	cytochrome c oxidase, subunit III
SynWH7803_0714	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynWH7803_0719	COG0659	secondary active sulfate transmembrane transporter activity
SynWH7803_0720	COG0418	dihydroorotase activity
SynWH7803_0728	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynWH7803_0728	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynWH7803_0732	COG0159	tryptophan synthase activity
SynWH7803_0735	COG2010	Cytochrome c
SynWH7803_0741	COG3339	Conserved Protein
SynWH7803_0742	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH7803_0745	COG1376	ErfK ybiS ycfS ynhG family protein
SynWH7803_0746	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynWH7803_0746	COG0140	phosphoribosyl-ATP diphosphatase activity
SynWH7803_0748	COG0542	response to heat
SynWH7803_0749	COG0542	response to heat
SynWH7803_0753	COG3794	PFAM blue (type 1) copper domain protein
SynWH7803_0755	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynWH7803_0756	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynWH7803_0763	COG1940	carbohydrate kinase activity
SynWH7803_0764	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynWH7803_0771	COG0339	signal peptide processing
SynWH7803_0772	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH7803_0773	COG0083	homoserine kinase activity
SynWH7803_0774	COG0837	glucose binding
SynWH7803_0776	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynWH7803_0780	COG0180	Tryptophanyl-tRNA synthetase
SynWH7803_0782	COG1230	cation diffusion facilitator family transporter
SynWH7803_0792	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SynWH7803_0798	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynWH7803_0805	COG2226	methyltransferase
SynWH7803_0811	COG3781	membrane
SynWH7803_0815	COG1064	alcohol dehydrogenase
SynWH7803_0822	COG2084	Dehydrogenase
SynWH7803_0857	COG0484	heat shock protein binding
SynWH7803_0866	COG0405	Gamma-glutamyltransferase
SynWH7803_0869	COG3961	Belongs to the TPP enzyme family
SynWH7803_0876	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SynWH7803_0877	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SynWH7803_0893	COG0671	phosphoesterase, PA-phosphatase related
SynWH7803_0899	COG2197	response regulator
SynWH7803_0931	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynWH7803_0950	COG0300	oxidoreductase activity
SynWH7803_0971	COG0651	ATP synthesis coupled electron transport
SynWH7803_0972	COG1006	Multisubunit Na H antiporter MnhC subunit
SynWH7803_0979	COG1121	(ABC) transporter
SynWH7803_0980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynWH7803_0984	COG2010	Cytochrome c
SynWH7803_0985	COG0701	Predicted permease
SynWH7803_0988	COG1121	(ABC) transporter
SynWH7803_0989	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynWH7803_0993	COG3659	wide pore channel activity
SynWH7803_1001	COG2890	protein-(glutamine-N5) methyltransferase activity
SynWH7803_1006	COG2124	cytochrome p450
SynWH7803_1020	COG0681	Belongs to the peptidase S26 family
SynWH7803_1021	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynWH7803_1022	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynWH7803_1023	COG1376	ErfK ybiS ycfS ynhG family protein
SynWH7803_1026	COG0297	glycogen (starch) synthase activity
SynWH7803_1028	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynWH7803_1030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynWH7803_1032	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynWH7803_1033	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynWH7803_1034	COG2045	Belongs to the ComB family
SynWH7803_1035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynWH7803_1037	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynWH7803_1038	COG0142	geranyltranstransferase activity
SynWH7803_1039	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynWH7803_1040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynWH7803_1042	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynWH7803_1043	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SynWH7803_1045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynWH7803_1046	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynWH7803_1049	COG2146	nitrite reductase [NAD(P)H] activity
SynWH7803_1052	COG0189	ligase activity
SynWH7803_1056	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynWH7803_1058	COG1132	(ABC) transporter
SynWH7803_1060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynWH7803_1061	COG0505	Belongs to the CarA family
SynWH7803_1063	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynWH7803_1064	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynWH7803_1066	COG0154	amidase activity
SynWH7803_1067	COG0587	DNA-directed DNA polymerase activity
SynWH7803_1069	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynWH7803_1070	COG0632	four-way junction helicase activity
SynWH7803_1073	COG0358	DNA primase activity
SynWH7803_1075	COG0798	PFAM Bile acid sodium symporter
SynWH7803_1081	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynWH7803_1085	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynWH7803_1086	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynWH7803_1086	COG2308	Evidence 4 Homologs of previously reported genes of
SynWH7803_1094	COG0861	Integral membrane protein TerC family
SynWH7803_1098	COG0513	Belongs to the DEAD box helicase family
SynWH7803_1099	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynWH7803_1101	COG0312	modulator of DNA gyrase
SynWH7803_1102	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynWH7803_1105	COG0163	prenyltransferase activity
SynWH7803_1106	COG0557	exoribonuclease II activity
SynWH7803_1108	COG2119	membrane
SynWH7803_1111	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynWH7803_1111	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynWH7803_1115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynWH7803_1116	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynWH7803_1117	COG1615	UPF0182 protein
SynWH7803_1118	COG0450	alkyl hydroperoxide reductase
SynWH7803_1120	COG0739	heme binding
SynWH7803_1121	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynWH7803_1128	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynWH7803_1131	COG0129	dihydroxy-acid dehydratase activity
SynWH7803_1133	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynWH7803_1136	COG2211	Major facilitator Superfamily
SynWH7803_1139	COG1028	Short-chain dehydrogenase reductase Sdr
SynWH7803_1141	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynWH7803_1142	COG0047	phosphoribosylformylglycinamidine synthase activity
SynWH7803_1143	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynWH7803_1145	COG0191	fructose-bisphosphate aldolase activity
SynWH7803_1146	COG0673	inositol 2-dehydrogenase activity
SynWH7803_1148	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynWH7803_1149	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynWH7803_1151	COG3954	Phosphoribulokinase
SynWH7803_1152	COG0473	3-isopropylmalate dehydrogenase activity
SynWH7803_1153	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynWH7803_1154	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynWH7803_1157	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynWH7803_1160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynWH7803_1161	COG2197	response regulator
SynWH7803_1163	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynWH7803_1164	COG1090	epimerase
SynWH7803_1165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SynWH7803_1168	COG1376	ErfK ybiS ycfS ynhG family protein
SynWH7803_1173	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynWH7803_1178	COG3659	wide pore channel activity
SynWH7803_1179	COG1119	ATPase activity
SynWH7803_1181	COG1051	belongs to the nudix hydrolase family
SynWH7803_1188	COG1201	RNA secondary structure unwinding
SynWH7803_1192	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynWH7803_1194	COG1793	dna ligase
SynWH7803_1196	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SynWH7803_1196	COG1793	dna ligase
SynWH7803_1197	COG2132	Multicopper oxidase
SynWH7803_1204	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynWH7803_1206	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynWH7803_1210	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynWH7803_1214	COG0740	serine-type endopeptidase activity
SynWH7803_1216	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynWH7803_1217	COG0577	efflux transmembrane transporter activity
SynWH7803_1217	COG1136	(ABC) transporter
SynWH7803_1218	COG0469	pyruvate kinase activity
SynWH7803_1222	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynWH7803_1223	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynWH7803_1228	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynWH7803_1229	COG0598	Magnesium transport protein CorA
SynWH7803_1231	COG3842	ATPase activity
SynWH7803_1234	COG1653	transport
SynWH7803_1235	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynWH7803_1236	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynWH7803_1237	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynWH7803_1238	COG0326	Molecular chaperone. Has ATPase activity
SynWH7803_1240	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynWH7803_1241	COG0483	inositol monophosphate 1-phosphatase activity
SynWH7803_1242	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynWH7803_1243	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynWH7803_1244	COG0581	inorganic phosphate transmembrane transporter activity
SynWH7803_1245	COG0573	inorganic phosphate transmembrane transporter activity
SynWH7803_1246	COG0443	Heat shock 70 kDa protein
SynWH7803_1247	COG0484	heat shock protein binding
SynWH7803_1249	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynWH7803_1250	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynWH7803_1251	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynWH7803_1252	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynWH7803_1252	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynWH7803_1253	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynWH7803_1254	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynWH7803_1259	COG0166	Belongs to the GPI family
SynWH7803_1260	COG0495	leucyl-tRNA aminoacylation
SynWH7803_1262	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynWH7803_1263	COG1104	cysteine desulfurase activity
SynWH7803_1268	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SynWH7803_1269	COG0322	excinuclease ABC activity
SynWH7803_1271	COG3046	protein related to deoxyribodipyrimidine photolyase
SynWH7803_1276	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynWH7803_1277	COG0646	methionine synthase
SynWH7803_1277	COG1410	methionine synthase
SynWH7803_1282	COG2385	sporulation resulting in formation of a cellular spore
SynWH7803_1289	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynWH7803_1290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynWH7803_1290	COG0072	phenylalanine-tRNA ligase activity
SynWH7803_1291	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynWH7803_1292	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynWH7803_1293	COG0557	exoribonuclease II activity
SynWH7803_1296	COG0363	glucosamine-6-phosphate deaminase activity
SynWH7803_1297	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynWH7803_1298	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynWH7803_1299	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynWH7803_1300	COG1494	fructose-1,6-bisphosphatase
SynWH7803_1301	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynWH7803_1303	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynWH7803_1309	COG3220	belongs to the UPF0276 family
SynWH7803_1317	COG0644	oxidoreductase
SynWH7803_1318	COG0751	glycine-tRNA ligase activity
SynWH7803_1319	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynWH7803_1320	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynWH7803_1321	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynWH7803_1325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynWH7803_1326	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynWH7803_1328	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynWH7803_1329	COG0052	Belongs to the universal ribosomal protein uS2 family
SynWH7803_1330	COG1216	Glycosyl transferase, family 2
SynWH7803_1332	COG1136	(ABC) transporter
SynWH7803_1336	COG0612	Peptidase, M16
SynWH7803_1340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynWH7803_1341	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SynWH7803_1344	COG0590	tRNA wobble adenosine to inosine editing
SynWH7803_1345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynWH7803_1347	COG0174	glutamine synthetase
SynWH7803_1349	COG2226	methyltransferase
SynWH7803_1353	COG0515	serine threonine protein kinase
SynWH7803_1354	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynWH7803_1356	COG0628	permease
SynWH7803_1358	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynWH7803_1358	COG0426	domain, Protein
SynWH7803_1361	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynWH7803_1362	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynWH7803_1363	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynWH7803_1363	COG0022	dehydrogenase e1 component
SynWH7803_1365	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynWH7803_1366	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynWH7803_1367	COG0572	uridine kinase
SynWH7803_1371	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynWH7803_1374	COG0271	Belongs to the BolA IbaG family
SynWH7803_1375	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynWH7803_1377	COG0745	RESPONSE REGULATOR receiver
SynWH7803_1380	COG1233	COG1233 Phytoene dehydrogenase and related
SynWH7803_1382	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynWH7803_1385	COG0745	RESPONSE REGULATOR receiver
SynWH7803_1390	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynWH7803_1392	COG0735	belongs to the Fur family
SynWH7803_1401	COG0420	3'-5' exonuclease activity
SynWH7803_1405	COG0477	Major facilitator Superfamily
SynWH7803_1407	COG2873	o-acetylhomoserine
SynWH7803_1408	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynWH7803_1415	COG0765	amino acid transport
SynWH7803_1417	COG4597	amino acid ABC transporter
SynWH7803_1418	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynWH7803_1420	COG0659	secondary active sulfate transmembrane transporter activity
SynWH7803_1427	COG0799	negative regulation of ribosome biogenesis
SynWH7803_1429	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynWH7803_1431	COG1115	amino acid carrier protein
SynWH7803_1433	COG1132	(ABC) transporter
SynWH7803_1434	COG2501	S4 domain
SynWH7803_1435	COG0149	triose-phosphate isomerase activity
SynWH7803_1436	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynWH7803_1438	COG1429	ligase activity, forming nitrogen-metal bonds
SynWH7803_1439	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynWH7803_1441	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynWH7803_1442	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynWH7803_1444	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SynWH7803_1449	COG0745	RESPONSE REGULATOR receiver
SynWH7803_1461	COG0640	Transcriptional regulator
SynWH7803_1469	COG3639	organic phosphonate transmembrane transporter activity
SynWH7803_1470	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynWH7803_1470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynWH7803_1471	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynWH7803_1472	COG0436	Aminotransferase
SynWH7803_1474	COG1573	uracil-dna glycosylase
SynWH7803_1475	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynWH7803_1476	COG0793	Belongs to the peptidase S41A family
SynWH7803_1480	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynWH7803_1483	COG1191	sigma factor activity
SynWH7803_1484	COG1836	PFAM Integral membrane protein DUF92
SynWH7803_1489	COG1122	ATPase activity
SynWH7803_1490	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynWH7803_1493	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynWH7803_1494	COG4106	trans-aconitate 2-methyltransferase activity
SynWH7803_1495	COG0668	transmembrane transport
SynWH7803_1507	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynWH7803_1508	COG1074	ATP-dependent DNA helicase activity
SynWH7803_1509	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynWH7803_1511	COG0513	Belongs to the DEAD box helicase family
SynWH7803_1514	COG0724	RNA recognition motif
SynWH7803_1516	COG1132	(ABC) transporter
SynWH7803_1517	COG0475	glutathione-regulated potassium exporter activity
SynWH7803_1517	COG0589	response to stress
SynWH7803_1518	COG1316	TRANSCRIPTIONal
SynWH7803_1525	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynWH7803_1526	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynWH7803_1530	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynWH7803_1531	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynWH7803_1532	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynWH7803_1533	COG0019	diaminopimelate decarboxylase activity
SynWH7803_1534	COG0456	acetyltransferase
SynWH7803_1535	COG0542	response to heat
SynWH7803_1536	COG0371	Dehydrogenase
SynWH7803_1537	COG0596	Alpha beta hydrolase
SynWH7803_1537	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SynWH7803_1537	COG2226	methyltransferase
SynWH7803_1539	COG0575	Belongs to the CDS family
SynWH7803_1540	COG1982	Orn Lys Arg decarboxylase major
SynWH7803_1542	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynWH7803_1544	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH7803_1545	COG0745	RESPONSE REGULATOR receiver
SynWH7803_1546	COG5002	protein histidine kinase activity
SynWH7803_1547	COG1187	pseudouridine synthase activity
SynWH7803_1549	COG1640	4-alpha-glucanotransferase
SynWH7803_1550	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
SynWH7803_1553	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynWH7803_1555	COG0308	aminopeptidase N
SynWH7803_1558	COG2205	protein histidine kinase activity
SynWH7803_1560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SynWH7803_1561	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynWH7803_1562	COG3429	Glucose-6-phosphate dehydrogenase subunit
SynWH7803_1562	COG3409	Peptidoglycan-binding domain 1 protein
SynWH7803_1563	COG1797	cobyrinic acid a,c-diamide synthase activity
SynWH7803_1564	COG1254	Belongs to the acylphosphatase family
SynWH7803_1565	COG0406	alpha-ribazole phosphatase activity
SynWH7803_1567	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynWH7803_1569	COG0142	geranyltranstransferase activity
SynWH7803_1570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynWH7803_1571	COG1480	7TM receptor with intracellular HD hydrolase
SynWH7803_1572	COG0564	pseudouridine synthase activity
SynWH7803_1576	COG0011	TIGRFAM Protein of
SynWH7803_1580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynWH7803_1585	COG0395	ABC-type sugar transport system, permease component
SynWH7803_1586	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynWH7803_1587	COG1543	Belongs to the glycosyl hydrolase 57 family
SynWH7803_1588	COG0644	oxidoreductase
SynWH7803_1589	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynWH7803_1591	COG0516	GMP reductase activity
SynWH7803_1592	COG3118	belongs to the thioredoxin family
SynWH7803_1593	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynWH7803_1596	COG2010	Cytochrome c
SynWH7803_1600	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynWH7803_1601	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynWH7803_1602	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynWH7803_1605	COG2166	iron-sulfur cluster assembly
SynWH7803_1606	COG0460	homoserine dehydrogenase
SynWH7803_1613	COG4095	Psort location CytoplasmicMembrane, score
SynWH7803_1615	COG0012	GTP binding
SynWH7803_1616	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynWH7803_1617	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynWH7803_1617	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynWH7803_1618	COG0215	cysteine-tRNA ligase activity
SynWH7803_1621	COG0733	neurotransmitter:sodium symporter activity
SynWH7803_1622	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynWH7803_1627	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SynWH7803_1629	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SynWH7803_1634	COG0492	ferredoxin-NADP+ reductase activity
SynWH7803_1635	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynWH7803_1637	COG1187	pseudouridine synthase activity
SynWH7803_1638	COG2226	methyltransferase
SynWH7803_1640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynWH7803_1644	COG0440	acetolactate synthase activity
SynWH7803_1645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynWH7803_1656	COG0424	maF-like protein
SynWH7803_1658	COG1492	cobalamin metabolic process
SynWH7803_1664	COG0432	Pfam Uncharacterised protein family UPF0047
SynWH7803_1665	COG0477	Major facilitator Superfamily
SynWH7803_1680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynWH7803_1684	COG0393	Putative heavy-metal-binding
SynWH7803_1688	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynWH7803_1689	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynWH7803_1692	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynWH7803_1692	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynWH7803_1710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynWH7803_1711	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynWH7803_1712	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynWH7803_1713	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynWH7803_1715	COG0196	riboflavin kinase activity
SynWH7803_1716	COG0352	thiamine-phosphate diphosphorylase activity
SynWH7803_1721	COG1691	(AIR) carboxylase
SynWH7803_1723	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SynWH7803_1724	COG0336	Belongs to the RNA methyltransferase TrmD family
SynWH7803_1726	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynWH7803_1728	COG0670	Belongs to the BI1 family
SynWH7803_1729	COG1702	phosphate starvation-inducible protein PhoH
SynWH7803_1730	COG0228	four-way junction DNA binding
SynWH7803_1731	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynWH7803_1734	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynWH7803_1735	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynWH7803_1736	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH7803_1737	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynWH7803_1737	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynWH7803_1738	COG0482	sulfurtransferase activity
SynWH7803_1739	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynWH7803_1742	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SynWH7803_1743	COG0134	indole-3-glycerol-phosphate synthase activity
SynWH7803_1744	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynWH7803_1745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynWH7803_1746	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynWH7803_1747	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynWH7803_1748	COG0285	dihydrofolate synthase activity
SynWH7803_1754	COG4948	Mandelate Racemase Muconate Lactonizing
SynWH7803_1755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynWH7803_1756	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynWH7803_1759	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynWH7803_1760	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynWH7803_1761	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynWH7803_1762	COG4956	integral membrane protein (PIN domain superfamily)
SynWH7803_1763	COG0740	serine-type endopeptidase activity
SynWH7803_1764	COG0740	serine-type endopeptidase activity
SynWH7803_1765	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynWH7803_1766	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynWH7803_1770	COG0752	glycyl-tRNA synthetase alpha subunit
SynWH7803_1772	COG2226	methyltransferase
SynWH7803_1774	COG0107	imidazoleglycerol-phosphate synthase activity
SynWH7803_1776	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynWH7803_1777	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynWH7803_1778	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynWH7803_1778	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynWH7803_1779	COG3659	wide pore channel activity
SynWH7803_1780	COG3695	enzyme binding
SynWH7803_1782	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynWH7803_1783	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynWH7803_1786	COG5002	protein histidine kinase activity
SynWH7803_1793	COG0745	RESPONSE REGULATOR receiver
SynWH7803_1794	COG5002	protein histidine kinase activity
SynWH7803_1801	COG0481	GTPase activity
SynWH7803_1803	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynWH7803_1805	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynWH7803_1806	COG0523	cobalamin synthesis protein
SynWH7803_1808	COG1840	ABC-type Fe3 transport system, periplasmic component
SynWH7803_1812	COG2271	Major facilitator Superfamily
SynWH7803_1814	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynWH7803_1820	COG0277	FAD linked oxidase domain protein
SynWH7803_1821	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynWH7803_1823	COG1666	GTP binding
SynWH7803_1826	COG0330	HflC and HflK could
SynWH7803_1829	COG0857	belongs to the CobB CobQ family
SynWH7803_1831	COG0300	oxidoreductase activity
SynWH7803_1831	COG3000	fatty acid hydroxylase
SynWH7803_1832	COG0024	Methionine aminopeptidase
SynWH7803_1834	COG0335	large ribosomal subunit rRNA binding
SynWH7803_1836	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynWH7803_1837	COG3263	regulation of cellular component size
SynWH7803_1840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SynWH7803_1842	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynWH7803_1843	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynWH7803_1846	COG0194	GDP metabolic process
SynWH7803_1848	COG0805	protein transport
SynWH7803_1850	COG0723	plastoquinol--plastocyanin reductase activity
SynWH7803_1851	COG3258	Cytochrome c
SynWH7803_1852	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SynWH7803_1853	COG2875	Belongs to the precorrin methyltransferase family
SynWH7803_1855	COG0248	Ppx GppA phosphatase
SynWH7803_1856	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynWH7803_1857	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynWH7803_1858	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynWH7803_1860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynWH7803_1861	COG1028	Short-chain dehydrogenase reductase Sdr
SynWH7803_1863	COG0459	protein refolding
SynWH7803_1865	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynWH7803_1869	COG0109	protoheme IX farnesyltransferase activity
SynWH7803_1870	COG1612	heme a metabolic process
SynWH7803_1873	COG1845	cytochrome c oxidase, subunit III
SynWH7803_1880	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynWH7803_1883	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynWH7803_1884	COG1007	ATP synthesis coupled electron transport
SynWH7803_1885	COG0577	efflux transmembrane transporter activity
SynWH7803_1885	COG1136	(ABC) transporter
SynWH7803_1886	COG0745	RESPONSE REGULATOR receiver
SynWH7803_1887	COG0739	heme binding
SynWH7803_1888	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SynWH7803_1888	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SynWH7803_1889	COG0436	Aminotransferase
SynWH7803_1890	COG3118	belongs to the thioredoxin family
SynWH7803_1891	COG1842	Phage shock protein A
SynWH7803_1893	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynWH7803_1894	COG0697	spore germination
SynWH7803_1895	COG0616	signal peptide processing
SynWH7803_1898	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynWH7803_1899	COG0594	ribonuclease P activity
SynWH7803_1901	COG0706	membrane insertase activity
SynWH7803_1903	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynWH7803_1905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynWH7803_1906	COG0750	zinc metalloprotease
SynWH7803_1907	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynWH7803_1908	COG1185	polyribonucleotide nucleotidyltransferase activity
SynWH7803_1910	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynWH7803_1927	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynWH7803_1928	COG0776	regulation of translation
SynWH7803_1931	COG2211	Major facilitator Superfamily
SynWH7803_1932	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynWH7803_1935	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynWH7803_1942	COG0284	orotidine-5'-phosphate decarboxylase activity
SynWH7803_1946	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynWH7803_1951	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynWH7803_1954	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynWH7803_1956	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynWH7803_1957	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynWH7803_1958	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynWH7803_1960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynWH7803_1962	COG0151	Belongs to the GarS family
SynWH7803_1963	COG5002	protein histidine kinase activity
SynWH7803_1964	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynWH7803_1965	COG4251	negative regulation of phosphorylation
SynWH7803_1967	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynWH7803_1968	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynWH7803_1971	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynWH7803_1972	COG0217	transcriptional regulatory protein
SynWH7803_1974	COG0363	glucosamine-6-phosphate deaminase activity
SynWH7803_1975	COG2385	sporulation resulting in formation of a cellular spore
SynWH7803_1976	COG1234	tRNA 3'-trailer cleavage
SynWH7803_1977	COG2010	Cytochrome c
SynWH7803_1980	COG2264	protein methyltransferase activity
SynWH7803_1981	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynWH7803_1984	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynWH7803_1991	COG0443	Heat shock 70 kDa protein
SynWH7803_1994	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynWH7803_1995	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynWH7803_1997	COG1970	mechanosensitive ion channel activity
SynWH7803_1998	COG0459	protein refolding
SynWH7803_1999	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynWH7803_2000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynWH7803_2001	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynWH7803_2004	COG0387	Pfam Sodium calcium exchanger
SynWH7803_2005	COG0006	proline dipeptidase activity
SynWH7803_2006	COG1253	flavin adenine dinucleotide binding
SynWH7803_2007	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynWH7803_2008	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynWH7803_2009	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynWH7803_2009	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynWH7803_2011	COG3012	SEC-C Motif Domain Protein
SynWH7803_2012	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynWH7803_2014	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynWH7803_2016	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynWH7803_2017	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynWH7803_2018	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynWH7803_2019	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynWH7803_2021	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynWH7803_2022	COG0356	it plays a direct role in the translocation of protons across the membrane
SynWH7803_2024	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynWH7803_2025	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynWH7803_2029	COG0772	Belongs to the SEDS family
SynWH7803_2030	COG4232	protein-disulfide reductase activity
SynWH7803_2031	COG1333	cytochrome c biogenesis protein
SynWH7803_2032	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynWH7803_2035	COG0347	Belongs to the P(II) protein family
SynWH7803_2038	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynWH7803_2039	COG0114	fumarate hydratase activity
SynWH7803_2040	COG4581	dead DEAH box helicase
SynWH7803_2041	COG0385	Bile acid
SynWH7803_2042	COG0156	8-amino-7-oxononanoate synthase activity
SynWH7803_2045	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynWH7803_2045	COG4106	trans-aconitate 2-methyltransferase activity
SynWH7803_2048	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynWH7803_2051	COG0357	Ribosomal RNA small subunit methyltransferase G
SynWH7803_2057	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SynWH7803_2058	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynWH7803_2060	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynWH7803_2061	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynWH7803_2062	COG0085	RNA polymerase activity
SynWH7803_2063	COG0084	hydrolase, TatD family'
SynWH7803_2064	COG0268	Binds directly to 16S ribosomal RNA
SynWH7803_2065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynWH7803_2066	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynWH7803_2067	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynWH7803_2070	COG2197	response regulator
SynWH7803_2074	COG0641	radical SAM
SynWH7803_2076	COG0779	Required for maturation of 30S ribosomal subunits
SynWH7803_2077	COG0195	Participates in both transcription termination and antitermination
SynWH7803_2079	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynWH7803_2088	COG2988	succinylglutamate desuccinylase activity
SynWH7803_2091	COG0488	(ABC) transporter
SynWH7803_2095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynWH7803_2096	COG3842	ATPase activity
SynWH7803_2097	COG1193	negative regulation of DNA recombination
SynWH7803_2099	COG0113	porphobilinogen synthase activity
SynWH7803_2100	COG0484	heat shock protein binding
SynWH7803_2102	COG0659	secondary active sulfate transmembrane transporter activity
SynWH7803_2103	COG0431	NADPH-dependent FMN reductase
SynWH7803_2106	COG0300	oxidoreductase activity
SynWH7803_2120	COG0116	Belongs to the methyltransferase superfamily
SynWH7803_2124	COG1196	nuclear chromosome segregation
SynWH7803_2126	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynWH7803_2127	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynWH7803_2128	COG0439	Biotin carboxylase
SynWH7803_2131	COG0515	serine threonine protein kinase
SynWH7803_2135	COG4178	(ABC) transporter
SynWH7803_2136	COG0537	adenosine 5'-monophosphoramidase activity
SynWH7803_2138	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynWH7803_2141	COG0242	peptide deformylase activity
SynWH7803_2143	COG0235	Class ii aldolase
SynWH7803_2144	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynWH7803_2147	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynWH7803_2148	COG0719	Fe-S assembly protein
SynWH7803_2149	COG0396	ATPase activity
SynWH7803_2150	COG0719	Fe-S assembly protein
SynWH7803_2151	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynWH7803_2152	COG1830	Aldolase
SynWH7803_2156	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynWH7803_2159	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SynWH7803_2164	COG0033	Phosphoglucomutase
SynWH7803_2172	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynWH7803_2173	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynWH7803_2174	COG0175	sulfate reduction
SynWH7803_2175	COG1252	NADH dehydrogenase
SynWH7803_2176	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynWH7803_2177	COG3273	potassium ion transport
SynWH7803_2177	COG0471	metal ion transport
SynWH7803_2178	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynWH7803_2179	COG0569	domain protein
SynWH7803_2180	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynWH7803_2185	COG0488	(ABC) transporter
SynWH7803_2187	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynWH7803_2190	COG1643	Atp-dependent helicase
SynWH7803_2191	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynWH7803_2193	COG1570	exodeoxyribonuclease VII activity
SynWH7803_2194	COG1722	exodeoxyribonuclease VII activity
SynWH7803_2198	COG0483	inositol monophosphate 1-phosphatase activity
SynWH7803_2201	COG1968	undecaprenyl-diphosphatase activity
SynWH7803_2203	COG1555	photosystem II stabilization
SynWH7803_2204	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynWH7803_2205	COG4243	Vitamin k epoxide reductase
SynWH7803_2206	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynWH7803_2208	COG1032	radical SAM domain protein
SynWH7803_2213	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SynWH7803_2218	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SynWH7803_2220	COG0463	Glycosyl transferase, family 2
SynWH7803_2221	COG1587	Uroporphyrinogen-III synthase
SynWH7803_2224	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynWH7803_2225	COG0316	Belongs to the HesB IscA family
SynWH7803_2229	COG1090	epimerase
SynWH7803_2230	COG3263	regulation of cellular component size
SynWH7803_2233	COG0484	heat shock protein binding
SynWH7803_2234	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynWH7803_2235	COG3659	wide pore channel activity
SynWH7803_2236	COG3659	wide pore channel activity
SynWH7803_2241	COG1122	ATPase activity
SynWH7803_2242	COG0745	RESPONSE REGULATOR receiver
SynWH7803_2244	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynWH7803_2245	COG2217	Heavy metal translocating P-type atpase
SynWH7803_2246	COG3063	Type IV pilus biogenesis stability protein PilW
SynWH7803_2247	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynWH7803_2249	COG0416	fatty acid biosynthetic process
SynWH7803_2250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynWH7803_2251	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynWH7803_2254	COG1214	PFAM Peptidase M22, glycoprotease
SynWH7803_2269	COG1562	ergosterol biosynthetic process
SynWH7803_2270	COG0745	RESPONSE REGULATOR receiver
SynWH7803_2271	COG0745	RESPONSE REGULATOR receiver
SynWH7803_2271	COG3706	GGDEF domain
SynWH7803_2273	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynWH7803_2273	COG0493	'glutamate synthase
SynWH7803_2276	COG0583	DNA-binding transcription factor activity
SynWH7803_2278	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynWH7803_2280	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH7803_2282	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynWH7803_2287	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynWH7803_2288	COG0713	ATP synthesis coupled electron transport
SynWH7803_2289	COG0839	Belongs to the complex I subunit 6 family
SynWH7803_2290	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH7803_2291	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynWH7803_2292	COG0372	Belongs to the citrate synthase family
SynWH7803_2293	COG2062	phosphohistidine phosphatase, SixA
SynWH7803_2296	COG1420	regulation of RNA biosynthetic process
SynWH7803_2297	COG0683	leucine binding
SynWH7803_2299	COG0133	tryptophan synthase activity
SynWH7803_2300	COG2226	methyltransferase
SynWH7803_2301	COG0023	Translation Initiation Factor
SynWH7803_2302	COG0529	Catalyzes the synthesis of activated sulfate
SynWH7803_2303	COG0628	permease
SynWH7803_2304	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynWH7803_2306	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynWH7803_2308	COG0564	pseudouridine synthase activity
SynWH7803_2309	COG0745	RESPONSE REGULATOR receiver
SynWH7803_2311	COG1104	cysteine desulfurase activity
SynWH7803_2313	COG0275	rRNA processing
SynWH7803_2314	COG0649	NAD binding
SynWH7803_2315	COG0824	Thioesterase
SynWH7803_2318	COG1575	Belongs to the MenA family. Type 1 subfamily
SynWH7803_2321	COG0189	ligase activity
SynWH7803_2322	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynWH7803_2325	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynWH7803_2327	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynWH7803_2328	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynWH7803_2329	COG0512	Glutamine amidotransferase of anthranilate synthase
SynWH7803_2331	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynWH7803_2334	COG0252	asparaginase activity
SynWH7803_2336	COG0018	arginyl-trna synthetase
SynWH7803_2337	COG0157	Belongs to the NadC ModD family
SynWH7803_2339	COG0242	peptide deformylase activity
SynWH7803_2340	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynWH7803_2342	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynWH7803_2343	COG4172	Belongs to the ABC transporter superfamily
SynWH7803_2348	COG0564	pseudouridine synthase activity
SynWH7803_2350	COG0589	response to stress
SynWH7803_2351	COG0126	phosphoglycerate kinase activity
SynWH7803_2357	COG0126	phosphoglycerate kinase activity
SynWH7803_2359	COG2084	Dehydrogenase
SynWH7803_2361	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynWH7803_2362	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynWH7803_2368	COG0167	dihydroorotate dehydrogenase activity
SynWH7803_2371	COG0222	ribosome binding
SynWH7803_2372	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynWH7803_2373	COG0081	regulation of translation
SynWH7803_2374	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynWH7803_2375	COG0250	Participates in transcription elongation, termination and antitermination
SynWH7803_2376	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynWH7803_2377	COG0542	response to heat
SynWH7803_2379	COG0148	phosphopyruvate hydratase activity
SynWH7803_2380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynWH7803_2383	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynWH7803_2384	COG0237	dephospho-CoA kinase activity
SynWH7803_2385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynWH7803_2388	COG0105	UTP biosynthetic process
SynWH7803_2389	COG1166	arginine decarboxylase activity
SynWH7803_2394	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SynWH7803_2396	COG0668	transmembrane transport
SynWH7803_2398	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynWH7803_2400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynWH7803_2405	COG0426	domain, Protein
SynWH7803_2405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynWH7803_2406	COG0426	domain, Protein
SynWH7803_2406	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynWH7803_2408	COG1741	Belongs to the pirin family
SynWH7803_2413	COG0509	glycine decarboxylation via glycine cleavage system
SynWH7803_2414	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynWH7803_2418	COG0359	binds to the 23S rRNA
SynWH7803_2419	COG0305	Participates in initiation and elongation during chromosome replication
SynWH7803_2419	COG1372	Participates in initiation and elongation during chromosome replication
SynWH7803_2419	COG1372	Participates in initiation and elongation during chromosome replication
SynWH7803_2419	COG0305	Participates in initiation and elongation during chromosome replication
SynWH7803_2420	COG0445	tRNA wobble uridine modification
SynWH7803_2428	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynWH7803_2431	COG0398	Pfam SNARE associated Golgi protein
SynWH7803_2436	COG0668	transmembrane transport
SynWH7803_2439	COG1131	(ABC) transporter
SynWH7803_2440	COG0525	valine-tRNA ligase activity
SynWH7803_2442	COG3264	Mechanosensitive ion channel
SynWH7803_2442	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SynWH7803_2446	COG1028	Short-chain dehydrogenase reductase Sdr
SynWH7803_2449	COG3956	TIGRFAM MazG family protein
SynWH7803_2450	COG0412	Dienelactone hydrolase
SynWH7803_2451	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynWH7803_2454	COG0010	Belongs to the arginase family
SynWH7803_2457	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SynWH7803_2458	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynWH7803_2459	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH7803_2460	COG0783	Belongs to the Dps family
SynWH7803_2461	COG0504	CTP synthase activity
SynWH7803_2462	COG0602	queuosine metabolic process
SynWH7803_2463	COG4942	peptidase
SynWH7803_2464	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SynWH7803_2468	COG4574	serine-type endopeptidase inhibitor activity
SynWH7803_2469	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynWH7803_2470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynWH7803_2472	COG0531	amino acid
SynWH7803_2474	COG0366	Alpha amylase catalytic
SynWH7803_2475	COG0463	Glycosyl transferase, family 2
SynWH7803_2478	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynWH7803_2480	COG2223	nitrite transmembrane transporter activity
SynWH7803_2481	COG0243	molybdopterin cofactor binding
SynWH7803_2484	COG0315	cyclic pyranopterin monophosphate synthase activity
SynWH7803_2485	COG0303	'Molybdopterin
SynWH7803_2486	COG0314	molybdopterin synthase activity
SynWH7803_2487	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SynWH7803_2488	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynWH7803_2489	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynWH7803_2492	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynWH7803_2493	COG2116	formate transmembrane transporter activity
SynWH7803_2495	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynWH7803_2497	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynWH7803_2500	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynWH7803_2501	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH7803_2502	COG0170	dolichyl monophosphate biosynthetic process
SynWH7803_2504	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynWH7803_2505	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynWH7803_2509	COG0788	formyltetrahydrofolate deformylase activity
SynWH7803_2512	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynWH7803_2514	COG0443	Heat shock 70 kDa protein
SynWH7803_2515	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynWH7803_2517	COG0360	Binds together with S18 to 16S ribosomal RNA
SynWH7803_2519	COG0137	argininosuccinate synthase activity
SynWH7803_2522	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynWH7803_2526	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynWH7803_2527	COG0438	transferase activity, transferring glycosyl groups
SynWH7803_2529	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynWH7803_2530	COG0497	DNA recombination
SynWH7803_2531	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynWH7803_2533	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine