locus-tag	class	description
SynWH8101_0001	COG0592	DNA-directed DNA polymerase activity
SynWH8101_0003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynWH8101_0004	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SynWH8101_0005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynWH8101_0007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SynWH8101_0010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynWH8101_0011	COG0552	protein localization to endoplasmic reticulum
SynWH8101_0012	COG2208	phosphoserine phosphatase activity
SynWH8101_0013	COG0165	Argininosuccinate lyase
SynWH8101_0014	COG0724	RNA recognition motif
SynWH8101_0015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynWH8101_0016	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynWH8101_0017	COG2081	HI0933 family
SynWH8101_0020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SynWH8101_0021	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SynWH8101_0022	COG0484	heat shock protein binding
SynWH8101_0024	COG1162	GTPase activity
SynWH8101_0025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SynWH8101_0026	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SynWH8101_0027	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SynWH8101_0028	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SynWH8101_0029	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SynWH8101_0030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynWH8101_0031	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SynWH8101_0032	COG0511	ligase activity, forming carbon-carbon bonds
SynWH8101_0033	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SynWH8101_0046	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SynWH8101_0047	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SynWH8101_0047	COG0519	Catalyzes the synthesis of GMP from XMP
SynWH8101_0064	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_0064	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynWH8101_0065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynWH8101_0067	COG2022	thiamine diphosphate biosynthetic process
SynWH8101_0070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SynWH8101_0071	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SynWH8101_0072	COG2385	sporulation resulting in formation of a cellular spore
SynWH8101_0073	COG1215	transferase activity, transferring glycosyl groups
SynWH8101_0077	COG1215	transferase activity, transferring glycosyl groups
SynWH8101_0078	COG3415	Transposase
SynWH8101_0078	COG2801	Transposase and inactivated derivatives
SynWH8101_0080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SynWH8101_0082	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SynWH8101_0083	COG0740	serine-type endopeptidase activity
SynWH8101_0084	COG0544	peptidyl-prolyl cis-trans isomerase activity
SynWH8101_0085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SynWH8101_0086	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SynWH8101_0087	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SynWH8101_0089	COG0037	tRNA processing
SynWH8101_0092	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SynWH8101_0093	COG0556	nucleotide-excision repair
SynWH8101_0096	COG2082	Precorrin-8x methylmutase
SynWH8101_0098	COG2274	protein secretion by the type I secretion system
SynWH8101_0101	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SynWH8101_0104	COG0653	protein targeting
SynWH8101_0105	COG1045	serine acetyltransferase
SynWH8101_0106	COG1725	Transcriptional regulator
SynWH8101_0108	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SynWH8101_0109	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SynWH8101_0110	COG0187	DNA topoisomerase II activity
SynWH8101_0110	COG1372	Participates in initiation and elongation during chromosome replication
SynWH8101_0112	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynWH8101_0113	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SynWH8101_0114	COG0386	Belongs to the glutathione peroxidase family
SynWH8101_0115	COG2239	Acts as a magnesium transporter
SynWH8101_0116	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_0123	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SynWH8101_0124	COG1301	dicarboxylic acid transport
SynWH8101_0125	COG3961	Belongs to the TPP enzyme family
SynWH8101_0126	COG0402	S-adenosylhomocysteine deaminase activity
SynWH8101_0128	COG0523	cobalamin synthesis protein
SynWH8101_0129	COG0477	Major facilitator Superfamily
SynWH8101_0132	COG0802	atpase or kinase
SynWH8101_0133	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SynWH8101_0134	COG0586	Pfam SNARE associated Golgi protein
SynWH8101_0135	COG0629	single-stranded DNA binding
SynWH8101_0140	COG0745	RESPONSE REGULATOR receiver
SynWH8101_0141	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SynWH8101_0145	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SynWH8101_0146	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SynWH8101_0147	COG0515	serine threonine protein kinase
SynWH8101_0148	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SynWH8101_0149	COG2255	four-way junction helicase activity
SynWH8101_0151	COG1473	amidohydrolase
SynWH8101_0154	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SynWH8101_0156	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SynWH8101_0157	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SynWH8101_0158	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SynWH8101_0159	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH8101_0160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SynWH8101_0162	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SynWH8101_0164	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynWH8101_0165	COG0571	ribonuclease III activity
SynWH8101_0171	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SynWH8101_0172	COG0058	SHG alpha-glucan phosphorylase activity
SynWH8101_0173	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SynWH8101_0174	COG0475	glutathione-regulated potassium exporter activity
SynWH8101_0178	COG0277	FAD linked oxidase domain protein
SynWH8101_0181	COG0247	lactate metabolic process
SynWH8101_0185	COG0538	isocitrate dehydrogenase activity
SynWH8101_0186	COG0463	Glycosyl transferase, family 2
SynWH8101_0189	COG5398	heme oxygenase
SynWH8101_0191	COG1132	(ABC) transporter
SynWH8101_0192	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_0193	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_0194	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_0195	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_0199	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SynWH8101_0201	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SynWH8101_0203	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SynWH8101_0207	COG0617	tRNA 3'-terminal CCA addition
SynWH8101_0217	COG0709	Synthesizes selenophosphate from selenide and ATP
SynWH8101_0220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SynWH8101_0223	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SynWH8101_0224	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SynWH8101_0225	COG1132	(ABC) transporter
SynWH8101_0226	COG1086	Polysaccharide biosynthesis protein
SynWH8101_0230	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SynWH8101_0233	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynWH8101_0234	COG2089	acid synthase
SynWH8101_0237	COG2801	Transposase and inactivated derivatives
SynWH8101_0242	COG3328	transposase activity
SynWH8101_0247	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynWH8101_0258	COG2337	Toxic component of a toxin-antitoxin (TA) module
SynWH8101_0270	COG0124	histidyl-tRNA synthetase
SynWH8101_0272	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SynWH8101_0279	COG4447	cellulose binding
SynWH8101_0281	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH8101_0282	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH8101_0283	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH8101_0285	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SynWH8101_0286	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SynWH8101_0287	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SynWH8101_0288	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynWH8101_0288	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynWH8101_0289	COG0494	nUDIX hydrolase
SynWH8101_0290	COG0415	Belongs to the DNA photolyase family
SynWH8101_0295	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SynWH8101_0298	COG0131	Imidazoleglycerol-phosphate dehydratase
SynWH8101_0299	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SynWH8101_0302	COG2271	Major facilitator Superfamily
SynWH8101_0303	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SynWH8101_0307	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynWH8101_0308	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SynWH8101_0310	COG0354	folic acid binding
SynWH8101_0313	COG1253	flavin adenine dinucleotide binding
SynWH8101_0314	COG0673	inositol 2-dehydrogenase activity
SynWH8101_0318	COG0343	queuine tRNA-ribosyltransferase activity
SynWH8101_0323	COG0138	bifunctional purine biosynthesis protein purh
SynWH8101_0326	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SynWH8101_0327	COG0004	ammonium transporteR
SynWH8101_0328	COG1489	DNA binding
SynWH8101_0329	COG0728	peptidoglycan biosynthetic process
SynWH8101_0334	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SynWH8101_0335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynWH8101_0336	COG1546	Belongs to the CinA family
SynWH8101_0336	COG1058	Belongs to the CinA family
SynWH8101_0337	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SynWH8101_0338	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SynWH8101_0339	COG0066	3-isopropylmalate dehydratase activity
SynWH8101_0346	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SynWH8101_0347	COG0193	aminoacyl-tRNA hydrolase activity
SynWH8101_0350	COG4372	Transposase
SynWH8101_0351	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynWH8101_0352	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SynWH8101_0354	COG0717	Belongs to the dCTP deaminase family
SynWH8101_0355	COG3039	Transposase
SynWH8101_0358	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynWH8101_0363	COG2971	BadF BadG BcrA BcrD
SynWH8101_0365	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SynWH8101_0369	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SynWH8101_0373	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynWH8101_0374	COG1402	creatininase
SynWH8101_0375	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SynWH8101_0376	COG2094	Belongs to the DNA glycosylase MPG family
SynWH8101_0377	COG0540	Belongs to the ATCase OTCase family
SynWH8101_0385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SynWH8101_0388	COG0529	Catalyzes the synthesis of activated sulfate
SynWH8101_0388	COG2046	Belongs to the sulfate adenylyltransferase family
SynWH8101_0389	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynWH8101_0390	COG0800	Aldolase
SynWH8101_0392	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SynWH8101_0393	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynWH8101_0394	COG2226	methyltransferase
SynWH8101_0395	COG4175	Glycine betaine
SynWH8101_0396	COG4176	ABC-type proline glycine betaine transport system permease component
SynWH8101_0397	COG2113	Glycine betaine
SynWH8101_0398	COG0463	Glycosyl transferase, family 2
SynWH8101_0399	COG0366	Alpha amylase catalytic
SynWH8101_0405	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynWH8101_0406	COG0436	Aminotransferase
SynWH8101_0408	COG1530	ribonuclease E activity
SynWH8101_0409	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SynWH8101_0411	COG1605	Chorismate mutase
SynWH8101_0411	COG0077	Prephenate dehydratase
SynWH8101_0412	COG2226	methyltransferase
SynWH8101_0413	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SynWH8101_0414	COG0051	transcription antitermination factor activity, RNA binding
SynWH8101_0415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SynWH8101_0416	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SynWH8101_0417	COG0049	tRNA binding
SynWH8101_0418	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SynWH8101_0421	COG0067	glutamate synthase
SynWH8101_0421	COG0069	glutamate synthase activity
SynWH8101_0421	COG0070	glutamate synthase
SynWH8101_0426	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynWH8101_0430	COG2885	chlorophyll binding
SynWH8101_0431	COG2885	chlorophyll binding
SynWH8101_0438	COG0463	Glycosyl transferase, family 2
SynWH8101_0442	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SynWH8101_0444	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SynWH8101_0445	COG0254	rRNA binding
SynWH8101_0446	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SynWH8101_0447	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SynWH8101_0449	COG0203	ribosomal protein L17
SynWH8101_0450	COG0202	RNA polymerase activity
SynWH8101_0451	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SynWH8101_0452	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SynWH8101_0453	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SynWH8101_0454	COG0563	adenylate kinase activity
SynWH8101_0455	COG0201	protein transport
SynWH8101_0456	COG0200	Binds to the 23S rRNA
SynWH8101_0457	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SynWH8101_0458	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SynWH8101_0459	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SynWH8101_0460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SynWH8101_0461	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SynWH8101_0462	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SynWH8101_0463	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SynWH8101_0464	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SynWH8101_0465	COG0255	Belongs to the universal ribosomal protein uL29 family
SynWH8101_0466	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SynWH8101_0467	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SynWH8101_0468	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SynWH8101_0469	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SynWH8101_0470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SynWH8101_0471	COG0089	rRNA binding
SynWH8101_0472	COG0088	Forms part of the polypeptide exit tunnel
SynWH8101_0473	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SynWH8101_0476	COG3854	ATPases associated with a variety of cellular activities
SynWH8101_0479	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SynWH8101_0489	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SynWH8101_0490	COG1606	tRNA processing
SynWH8101_0491	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SynWH8101_0492	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SynWH8101_0495	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SynWH8101_0496	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SynWH8101_0497	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SynWH8101_0500	COG0772	Belongs to the SEDS family
SynWH8101_0501	COG0489	protein tyrosine kinase activity
SynWH8101_0502	COG0408	coproporphyrinogen oxidase activity
SynWH8101_0514	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SynWH8101_0515	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SynWH8101_0516	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SynWH8101_0516	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SynWH8101_0517	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SynWH8101_0555	COG1070	Carbohydrate kinase
SynWH8101_0556	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SynWH8101_0557	COG0546	phosphoglycolate phosphatase activity
SynWH8101_0558	COG0539	negative regulation of cytoplasmic translation
SynWH8101_0559	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SynWH8101_0564	COG0589	response to stress
SynWH8101_0566	COG0758	DNA mediated transformation
SynWH8101_0567	COG2890	protein-(glutamine-N5) methyltransferase activity
SynWH8101_0570	COG2197	response regulator
SynWH8101_0571	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SynWH8101_0572	COG2894	cell division
SynWH8101_0573	COG0850	regulation of cytokinetic process
SynWH8101_0576	COG2059	Chromate
SynWH8101_0577	COG1078	dGTPase activity
SynWH8101_0578	COG0793	Belongs to the peptidase S41A family
SynWH8101_0579	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynWH8101_0580	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SynWH8101_0587	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SynWH8101_0588	COG0235	Class ii aldolase
SynWH8101_0589	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SynWH8101_0592	COG0514	ATP-dependent DNA helicase (RecQ)
SynWH8101_0593	COG3942	CHAP domain
SynWH8101_0593	COG1388	LysM domain
SynWH8101_0594	COG1012	belongs to the aldehyde dehydrogenase family
SynWH8101_0596	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SynWH8101_0600	COG0745	RESPONSE REGULATOR receiver
SynWH8101_0604	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SynWH8101_0607	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SynWH8101_0612	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SynWH8101_0616	COG1160	GTP binding
SynWH8101_0617	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SynWH8101_0619	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SynWH8101_0620	COG1799	cell septum assembly
SynWH8101_0621	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SynWH8101_0622	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_0624	COG1381	Involved in DNA repair and RecF pathway recombination
SynWH8101_0626	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SynWH8101_0627	COG0321	lipoyl(octanoyl) transferase activity
SynWH8101_0628	COG1022	Amp-dependent synthetase and ligase
SynWH8101_0636	COG1475	DNA binding
SynWH8101_0638	COG0508	dehydrogenase complex catalyzes the overall conversion of
SynWH8101_0642	COG0531	amino acid
SynWH8101_0643	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SynWH8101_0644	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynWH8101_0647	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SynWH8101_0650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SynWH8101_0653	COG0189	ligase activity
SynWH8101_0653	COG4067	protein conserved in archaea
SynWH8101_0655	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SynWH8101_0656	COG0579	oxidoreductase
SynWH8101_0658	COG0481	GTPase activity
SynWH8101_0665	COG4969	Belongs to the N-Me-Phe pilin family
SynWH8101_0666	COG5002	protein histidine kinase activity
SynWH8101_0667	COG0745	RESPONSE REGULATOR receiver
SynWH8101_0672	COG2205	protein histidine kinase activity
SynWH8101_0675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynWH8101_0677	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SynWH8101_0677	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SynWH8101_0678	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SynWH8101_0679	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynWH8101_0681	COG0107	imidazoleglycerol-phosphate synthase activity
SynWH8101_0683	COG2226	methyltransferase
SynWH8101_0685	COG0752	glycyl-tRNA synthetase alpha subunit
SynWH8101_0693	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SynWH8101_0695	COG2217	Heavy metal translocating P-type atpase
SynWH8101_0701	COG0297	glycogen (starch) synthase activity
SynWH8101_0704	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SynWH8101_0705	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SynWH8101_0706	COG0740	serine-type endopeptidase activity
SynWH8101_0707	COG0740	serine-type endopeptidase activity
SynWH8101_0708	COG4956	integral membrane protein (PIN domain superfamily)
SynWH8101_0709	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SynWH8101_0710	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SynWH8101_0713	COG1181	Belongs to the D-alanine--D-alanine ligase family
SynWH8101_0714	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynWH8101_0715	COG4948	Mandelate Racemase Muconate Lactonizing
SynWH8101_0722	COG0285	dihydrofolate synthase activity
SynWH8101_0723	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynWH8101_0724	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SynWH8101_0725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SynWH8101_0728	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynWH8101_0729	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynWH8101_0730	COG0134	indole-3-glycerol-phosphate synthase activity
SynWH8101_0732	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SynWH8101_0735	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SynWH8101_0736	COG0482	sulfurtransferase activity
SynWH8101_0737	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SynWH8101_0737	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SynWH8101_0738	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_0739	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SynWH8101_0741	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SynWH8101_0743	COG1702	phosphate starvation-inducible protein PhoH
SynWH8101_0745	COG0477	Major facilitator Superfamily
SynWH8101_0748	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SynWH8101_0750	COG0336	Belongs to the RNA methyltransferase TrmD family
SynWH8101_0751	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SynWH8101_0753	COG1691	(AIR) carboxylase
SynWH8101_0757	COG0352	thiamine-phosphate diphosphorylase activity
SynWH8101_0758	COG0196	riboflavin kinase activity
SynWH8101_0760	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SynWH8101_0761	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SynWH8101_0762	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynWH8101_0763	COG0745	RESPONSE REGULATOR receiver
SynWH8101_0773	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynWH8101_0773	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SynWH8101_0775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynWH8101_0776	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SynWH8101_0777	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynWH8101_0794	COG5002	protein histidine kinase activity
SynWH8101_0799	COG0432	Pfam Uncharacterised protein family UPF0047
SynWH8101_0804	COG1492	cobalamin metabolic process
SynWH8101_0808	COG0424	maF-like protein
SynWH8101_0811	COG0424	maF-like protein
SynWH8101_0820	COG2274	protein secretion by the type I secretion system
SynWH8101_0830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynWH8101_0831	COG0440	acetolactate synthase activity
SynWH8101_0837	COG2226	methyltransferase
SynWH8101_0840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SynWH8101_0841	COG0492	ferredoxin-NADP+ reductase activity
SynWH8101_0845	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SynWH8101_0847	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SynWH8101_0849	COG3411	Ferredoxin
SynWH8101_0850	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SynWH8101_0851	COG0733	neurotransmitter:sodium symporter activity
SynWH8101_0854	COG0215	cysteine-tRNA ligase activity
SynWH8101_0855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynWH8101_0855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SynWH8101_0856	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynWH8101_0857	COG0012	GTP binding
SynWH8101_0867	COG0460	homoserine dehydrogenase
SynWH8101_0868	COG2166	iron-sulfur cluster assembly
SynWH8101_0871	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SynWH8101_0873	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SynWH8101_0874	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SynWH8101_0877	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SynWH8101_0878	COG2010	Cytochrome c
SynWH8101_0881	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SynWH8101_0882	COG3118	belongs to the thioredoxin family
SynWH8101_0883	COG0516	GMP reductase activity
SynWH8101_0885	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SynWH8101_0886	COG0644	oxidoreductase
SynWH8101_0887	COG1543	Belongs to the glycosyl hydrolase 57 family
SynWH8101_0888	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SynWH8101_0889	COG0395	ABC-type sugar transport system, permease component
SynWH8101_0893	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynWH8101_0897	COG0011	TIGRFAM Protein of
SynWH8101_0901	COG0564	pseudouridine synthase activity
SynWH8101_0902	COG1480	7TM receptor with intracellular HD hydrolase
SynWH8101_0903	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SynWH8101_0906	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynWH8101_0908	COG0406	alpha-ribazole phosphatase activity
SynWH8101_0909	COG1254	Belongs to the acylphosphatase family
SynWH8101_0910	COG1797	cobyrinic acid a,c-diamide synthase activity
SynWH8101_0911	COG3409	Peptidoglycan-binding domain 1 protein
SynWH8101_0911	COG3429	Glucose-6-phosphate dehydrogenase subunit
SynWH8101_0912	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SynWH8101_0913	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SynWH8101_0916	COG2205	protein histidine kinase activity
SynWH8101_0919	COG0308	aminopeptidase N
SynWH8101_0921	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SynWH8101_0923	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
SynWH8101_0925	COG1187	pseudouridine synthase activity
SynWH8101_0926	COG5002	protein histidine kinase activity
SynWH8101_0927	COG0745	RESPONSE REGULATOR receiver
SynWH8101_0928	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_0930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynWH8101_0931	COG1982	Orn Lys Arg decarboxylase major
SynWH8101_0932	COG0575	Belongs to the CDS family
SynWH8101_0934	COG2267	carboxylic ester hydrolase activity
SynWH8101_0935	COG0371	Dehydrogenase
SynWH8101_0936	COG0542	response to heat
SynWH8101_0938	COG0019	diaminopimelate decarboxylase activity
SynWH8101_0939	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SynWH8101_0940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SynWH8101_0941	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SynWH8101_0945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SynWH8101_0946	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SynWH8101_0952	COG1285	pathogenesis
SynWH8101_0953	COG1316	TRANSCRIPTIONal
SynWH8101_0954	COG0475	glutathione-regulated potassium exporter activity
SynWH8101_0954	COG0589	response to stress
SynWH8101_0955	COG1132	(ABC) transporter
SynWH8101_0958	COG0724	RNA recognition motif
SynWH8101_0963	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynWH8101_0965	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SynWH8101_0970	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SynWH8101_0973	COG0271	Belongs to the BolA IbaG family
SynWH8101_0974	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SynWH8101_0976	COG0745	RESPONSE REGULATOR receiver
SynWH8101_0981	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SynWH8101_0983	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SynWH8101_0985	COG0582	viral genome integration into host DNA
SynWH8101_0991	COG4243	Vitamin k epoxide reductase
SynWH8101_0993	COG0789	Transcriptional regulator
SynWH8101_1000	COG5002	protein histidine kinase activity
SynWH8101_1003	COG2132	Multicopper oxidase
SynWH8101_1021	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_1024	COG0358	DNA primase activity
SynWH8101_1044	COG1487	ribonuclease activity
SynWH8101_1048	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynWH8101_1054	COG1970	mechanosensitive ion channel activity
SynWH8101_1059	COG1598	PFAM Uncharacterised protein family UPF0150
SynWH8101_1063	COG0724	RNA recognition motif
SynWH8101_1069	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynWH8101_1103	COG1115	amino acid carrier protein
SynWH8101_1105	COG0450	alkyl hydroperoxide reductase
SynWH8101_1106	COG1615	UPF0182 protein
SynWH8101_1107	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynWH8101_1108	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SynWH8101_1111	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynWH8101_1112	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SynWH8101_1112	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SynWH8101_1116	COG2119	membrane
SynWH8101_1118	COG0557	exoribonuclease II activity
SynWH8101_1119	COG0163	prenyltransferase activity
SynWH8101_1122	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynWH8101_1123	COG0312	modulator of DNA gyrase
SynWH8101_1125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SynWH8101_1126	COG0513	Belongs to the DEAD box helicase family
SynWH8101_1129	COG0861	Integral membrane protein TerC family
SynWH8101_1132	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SynWH8101_1136	COG0793	Belongs to the peptidase S41A family
SynWH8101_1137	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SynWH8101_1138	COG1573	uracil-dna glycosylase
SynWH8101_1139	COG0436	Aminotransferase
SynWH8101_1140	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SynWH8101_1141	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SynWH8101_1141	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynWH8101_1142	COG3639	organic phosphonate transmembrane transporter activity
SynWH8101_1145	COG1836	PFAM Integral membrane protein DUF92
SynWH8101_1149	COG1122	ATPase activity
SynWH8101_1150	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SynWH8101_1153	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SynWH8101_1154	COG4106	trans-aconitate 2-methyltransferase activity
SynWH8101_1162	COG0640	Transcriptional regulator
SynWH8101_1172	COG0745	RESPONSE REGULATOR receiver
SynWH8101_1180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SynWH8101_1181	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynWH8101_1183	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SynWH8101_1184	COG1429	ligase activity, forming nitrogen-metal bonds
SynWH8101_1186	COG5001	Diguanylate cyclase
SynWH8101_1187	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SynWH8101_1188	COG0149	triose-phosphate isomerase activity
SynWH8101_1190	COG1132	(ABC) transporter
SynWH8101_1193	COG1115	amino acid carrier protein
SynWH8101_1195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SynWH8101_1241	COG0010	Belongs to the arginase family
SynWH8101_1244	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SynWH8101_1245	COG1116	anion transmembrane transporter activity
SynWH8101_1254	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynWH8101_1276	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_1279	COG2094	Belongs to the DNA glycosylase MPG family
SynWH8101_1291	COG2226	methyltransferase
SynWH8101_1293	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_1295	COG0358	DNA primase activity
SynWH8101_1300	COG3657	addiction module killer protein
SynWH8101_1301	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SynWH8101_1332	COG2197	response regulator
SynWH8101_1338	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SynWH8101_1343	COG0659	secondary active sulfate transmembrane transporter activity
SynWH8101_1345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SynWH8101_1346	COG4597	amino acid ABC transporter
SynWH8101_1348	COG0765	amino acid transport
SynWH8101_1349	COG1126	abc transporter atp-binding protein
SynWH8101_1354	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SynWH8101_1355	COG2873	o-acetylhomoserine
SynWH8101_1363	COG0625	glutathione transferase activity
SynWH8101_1370	COG0735	belongs to the Fur family
SynWH8101_1371	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SynWH8101_1375	COG0259	pyridoxamine-phosphate oxidase activity
SynWH8101_1377	COG0723	plastoquinol--plastocyanin reductase activity
SynWH8101_1384	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynWH8101_1386	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SynWH8101_1389	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SynWH8101_1393	COG0656	L-ascorbic acid biosynthetic process
SynWH8101_1394	COG0501	Belongs to the peptidase M48B family
SynWH8101_1396	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynWH8101_1396	COG0426	domain, Protein
SynWH8101_1397	COG1970	mechanosensitive ion channel activity
SynWH8101_1400	COG0739	heme binding
SynWH8101_1401	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SynWH8101_1408	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynWH8101_1413	COG0784	Response regulator, receiver
SynWH8101_1413	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SynWH8101_1414	COG0402	S-adenosylhomocysteine deaminase activity
SynWH8101_1417	COG2197	response regulator
SynWH8101_1419	COG2274	protein secretion by the type I secretion system
SynWH8101_1420	COG1132	(ABC) transporter
SynWH8101_1436	COG1028	Short-chain dehydrogenase reductase Sdr
SynWH8101_1443	COG0557	exoribonuclease II activity
SynWH8101_1444	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SynWH8101_1445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SynWH8101_1446	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SynWH8101_1446	COG0072	phenylalanine-tRNA ligase activity
SynWH8101_1447	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SynWH8101_1452	COG1191	sigma factor activity
SynWH8101_1454	COG2385	sporulation resulting in formation of a cellular spore
SynWH8101_1459	COG0646	methionine synthase
SynWH8101_1459	COG1410	methionine synthase
SynWH8101_1460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynWH8101_1463	COG0613	PHP domain protein
SynWH8101_1465	COG3046	protein related to deoxyribodipyrimidine photolyase
SynWH8101_1467	COG0322	excinuclease ABC activity
SynWH8101_1474	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SynWH8101_1476	COG0495	leucyl-tRNA aminoacylation
SynWH8101_1477	COG0166	Belongs to the GPI family
SynWH8101_1482	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SynWH8101_1483	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SynWH8101_1484	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynWH8101_1484	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SynWH8101_1485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SynWH8101_1486	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SynWH8101_1487	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SynWH8101_1489	COG0484	heat shock protein binding
SynWH8101_1490	COG0443	Heat shock 70 kDa protein
SynWH8101_1491	COG0573	inorganic phosphate transmembrane transporter activity
SynWH8101_1492	COG0581	inorganic phosphate transmembrane transporter activity
SynWH8101_1493	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynWH8101_1495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynWH8101_1496	COG0483	inositol monophosphate 1-phosphatase activity
SynWH8101_1497	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SynWH8101_1499	COG0326	Molecular chaperone. Has ATPase activity
SynWH8101_1500	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SynWH8101_1501	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynWH8101_1502	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SynWH8101_1503	COG1653	transport
SynWH8101_1509	COG0598	Magnesium transport protein CorA
SynWH8101_1510	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynWH8101_1516	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SynWH8101_1517	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SynWH8101_1521	COG0469	pyruvate kinase activity
SynWH8101_1522	COG0577	efflux transmembrane transporter activity
SynWH8101_1522	COG1136	(ABC) transporter
SynWH8101_1523	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynWH8101_1525	COG0740	serine-type endopeptidase activity
SynWH8101_1529	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SynWH8101_1530	COG2211	Major facilitator Superfamily
SynWH8101_1533	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SynWH8101_1535	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SynWH8101_1542	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SynWH8101_1542	COG1793	dna ligase
SynWH8101_1544	COG1793	dna ligase
SynWH8101_1545	COG1201	RNA secondary structure unwinding
SynWH8101_1551	COG1131	(ABC) transporter
SynWH8101_1553	COG3659	wide pore channel activity
SynWH8101_1557	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynWH8101_1562	COG1376	ErfK ybiS ycfS ynhG family protein
SynWH8101_1565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SynWH8101_1569	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SynWH8101_1571	COG2197	response regulator
SynWH8101_1572	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SynWH8101_1575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SynWH8101_1578	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SynWH8101_1579	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SynWH8101_1580	COG0473	3-isopropylmalate dehydrogenase activity
SynWH8101_1581	COG3954	Phosphoribulokinase
SynWH8101_1583	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SynWH8101_1584	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SynWH8101_1586	COG0673	inositol 2-dehydrogenase activity
SynWH8101_1587	COG0191	fructose-bisphosphate aldolase activity
SynWH8101_1588	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynWH8101_1589	COG0047	phosphoribosylformylglycinamidine synthase activity
SynWH8101_1590	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SynWH8101_1593	COG2211	Major facilitator Superfamily
SynWH8101_1596	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SynWH8101_1598	COG0129	dihydroxy-acid dehydratase activity
SynWH8101_1603	COG0363	glucosamine-6-phosphate deaminase activity
SynWH8101_1604	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SynWH8101_1605	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynWH8101_1606	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SynWH8101_1607	COG1494	fructose-1,6-bisphosphatase
SynWH8101_1608	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SynWH8101_1609	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SynWH8101_1615	COG0826	peptidase U32
SynWH8101_1617	COG0644	oxidoreductase
SynWH8101_1618	COG0751	glycine-tRNA ligase activity
SynWH8101_1619	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynWH8101_1620	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SynWH8101_1621	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SynWH8101_1623	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SynWH8101_1624	COG0052	Belongs to the universal ribosomal protein uS2 family
SynWH8101_1625	COG1216	Glycosyl transferase, family 2
SynWH8101_1626	COG0577	efflux transmembrane transporter activity
SynWH8101_1626	COG1136	(ABC) transporter
SynWH8101_1630	COG0612	Peptidase, M16
SynWH8101_1634	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SynWH8101_1635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SynWH8101_1638	COG0590	tRNA wobble adenosine to inosine editing
SynWH8101_1639	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SynWH8101_1641	COG0174	glutamine synthetase
SynWH8101_1643	COG2226	methyltransferase
SynWH8101_1647	COG0515	serine threonine protein kinase
SynWH8101_1648	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SynWH8101_1650	COG0628	permease
SynWH8101_1654	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynWH8101_1655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SynWH8101_1656	COG0022	dehydrogenase e1 component
SynWH8101_1658	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SynWH8101_1659	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SynWH8101_1660	COG0668	transmembrane transport
SynWH8101_1661	COG0792	nuclease activity
SynWH8101_1664	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SynWH8101_1666	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SynWH8101_1671	COG0798	PFAM Bile acid sodium symporter
SynWH8101_1673	COG0358	DNA primase activity
SynWH8101_1676	COG0632	four-way junction helicase activity
SynWH8101_1677	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SynWH8101_1679	COG0587	DNA-directed DNA polymerase activity
SynWH8101_1680	COG0154	amidase activity
SynWH8101_1682	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SynWH8101_1683	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SynWH8101_1685	COG0505	Belongs to the CarA family
SynWH8101_1686	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynWH8101_1687	COG1132	(ABC) transporter
SynWH8101_1689	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynWH8101_1692	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynWH8101_1693	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SynWH8101_1695	COG2176	DNA-directed DNA polymerase activity
SynWH8101_1696	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynWH8101_1698	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SynWH8101_1699	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SynWH8101_1700	COG0142	geranyltranstransferase activity
SynWH8101_1701	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SynWH8101_1703	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynWH8101_1704	COG2045	Belongs to the ComB family
SynWH8101_1705	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SynWH8101_1706	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SynWH8101_1707	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynWH8101_1707	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SynWH8101_1708	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SynWH8101_1709	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SynWH8101_1711	COG0297	glycogen (starch) synthase activity
SynWH8101_1712	COG1376	ErfK ybiS ycfS ynhG family protein
SynWH8101_1713	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SynWH8101_1714	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SynWH8101_1715	COG0681	Belongs to the peptidase S26 family
SynWH8101_1725	COG2274	protein secretion by the type I secretion system
SynWH8101_1730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SynWH8101_1731	COG0071	Belongs to the small heat shock protein (HSP20) family
SynWH8101_1733	COG1881	PFAM PEBP family protein
SynWH8101_1738	COG1032	radical SAM domain protein
SynWH8101_1743	COG0574	Belongs to the PEP-utilizing enzyme family
SynWH8101_1743	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SynWH8101_1748	COG1271	oxidase subunit
SynWH8101_1749	COG1294	oxidase, subunit
SynWH8101_1750	COG0450	alkyl hydroperoxide reductase
SynWH8101_1753	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SynWH8101_1757	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynWH8101_1758	COG1121	(ABC) transporter
SynWH8101_1760	COG3659	wide pore channel activity
SynWH8101_1761	COG2010	Cytochrome c
SynWH8101_1762	COG1006	Multisubunit Na H antiporter MnhC subunit
SynWH8101_1771	COG0701	Predicted permease
SynWH8101_1778	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SynWH8101_1781	COG0367	asparagine synthase
SynWH8101_1782	COG0540	Belongs to the ATCase OTCase family
SynWH8101_1785	COG1121	(ABC) transporter
SynWH8101_1790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SynWH8101_1791	COG0390	transport system, permease component
SynWH8101_1801	COG3039	Transposase
SynWH8101_1807	COG2094	Belongs to the DNA glycosylase MPG family
SynWH8101_1818	COG2094	Belongs to the DNA glycosylase MPG family
SynWH8101_1820	COG2094	Belongs to the DNA glycosylase MPG family
SynWH8101_1825	COG2274	protein secretion by the type I secretion system
SynWH8101_1833	COG2094	Belongs to the DNA glycosylase MPG family
SynWH8101_1843	COG0028	Belongs to the TPP enzyme family
SynWH8101_1852	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynWH8101_1855	COG1064	alcohol dehydrogenase
SynWH8101_1859	COG3781	membrane
SynWH8101_1863	COG2226	methyltransferase
SynWH8101_1871	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SynWH8101_1877	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SynWH8101_1880	COG1230	cation diffusion facilitator family transporter
SynWH8101_1882	COG0180	Tryptophanyl-tRNA synthetase
SynWH8101_1886	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SynWH8101_1889	COG0083	homoserine kinase activity
SynWH8101_1890	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH8101_1891	COG0339	signal peptide processing
SynWH8101_1897	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SynWH8101_1898	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SynWH8101_1899	COG1940	carbohydrate kinase activity
SynWH8101_1906	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SynWH8101_1907	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SynWH8101_1909	COG3794	PFAM blue (type 1) copper domain protein
SynWH8101_1914	COG0542	response to heat
SynWH8101_1916	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SynWH8101_1916	COG0140	phosphoribosyl-ATP diphosphatase activity
SynWH8101_1919	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_1928	COG0159	tryptophan synthase activity
SynWH8101_1933	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynWH8101_1933	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SynWH8101_1939	COG0251	oxidation-reduction process
SynWH8101_1942	COG0418	dihydroorotase activity
SynWH8101_1943	COG0659	secondary active sulfate transmembrane transporter activity
SynWH8101_1948	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynWH8101_1949	COG1845	cytochrome c oxidase, subunit III
SynWH8101_1955	COG0811	peptide transport
SynWH8101_1957	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SynWH8101_1958	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynWH8101_1961	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SynWH8101_1966	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SynWH8101_1967	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynWH8101_1970	COG0456	acetyltransferase
SynWH8101_1971	COG1132	(ABC) transporter
SynWH8101_1972	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SynWH8101_1973	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SynWH8101_1974	COG3842	ATPase activity
SynWH8101_1975	COG0251	oxidation-reduction process
SynWH8101_1981	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH8101_1982	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynWH8101_1988	COG4451	ribulose bisphosphate carboxylase, small
SynWH8101_1989	COG1850	ribulose-bisphosphate carboxylase activity
SynWH8101_1991	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SynWH8101_1995	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynWH8101_1996	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SynWH8101_1997	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SynWH8101_2002	COG0730	response to heat
SynWH8101_2003	COG0095	Lipoate-protein ligase
SynWH8101_2004	COG1994	Peptidase M50
SynWH8101_2004	COG0517	IMP dehydrogenase activity
SynWH8101_2005	COG0135	phosphoribosylanthranilate isomerase activity
SynWH8101_2007	COG0302	gtp cyclohydrolase
SynWH8101_2008	COG1028	Short-chain dehydrogenase reductase Sdr
SynWH8101_2009	COG0825	malonyl-CoA metabolic process
SynWH8101_2010	COG5322	oxidoreductase activity
SynWH8101_2011	COG3396	Phenylacetate-CoA oxygenase
SynWH8101_2013	COG0539	negative regulation of cytoplasmic translation
SynWH8101_2016	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SynWH8101_2020	COG0028	Belongs to the TPP enzyme family
SynWH8101_2021	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynWH8101_2022	COG0582	viral genome integration into host DNA
SynWH8101_2023	COG2226	methyltransferase
SynWH8101_2026	COG0528	UMP kinase activity
SynWH8101_2027	COG0233	cytoplasmic translational termination
SynWH8101_2029	COG0415	Belongs to the DNA photolyase family
SynWH8101_2031	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SynWH8101_2036	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SynWH8101_2037	COG0681	Belongs to the peptidase S26 family
SynWH8101_2041	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynWH8101_2043	COG0442	prolyl-tRNA aminoacylation
SynWH8101_2045	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SynWH8101_2046	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SynWH8101_2052	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SynWH8101_2054	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SynWH8101_2055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_2058	COG2095	MarC family integral membrane protein
SynWH8101_2060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SynWH8101_2076	COG2267	carboxylic ester hydrolase activity
SynWH8101_2103	COG0590	tRNA wobble adenosine to inosine editing
SynWH8101_2104	COG0484	heat shock protein binding
SynWH8101_2111	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynWH8101_2117	COG1013	pyruvate-flavodoxin oxidoreductase activity
SynWH8101_2117	COG0674	pyruvate-flavodoxin oxidoreductase activity
SynWH8101_2117	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SynWH8101_2117	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SynWH8101_2120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynWH8101_2121	COG0375	protein maturation
SynWH8101_2123	COG3259	Nickel-dependent hydrogenase
SynWH8101_2125	COG1034	ATP synthesis coupled electron transport
SynWH8101_2128	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynWH8101_2146	COG2135	peptidase activity
SynWH8101_2153	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SynWH8101_2155	COG0123	including yeast histone deacetylase and acetoin utilization protein
SynWH8101_2157	COG2154	pterin-4-alpha-carbinolamine dehydratase
SynWH8101_2158	COG0523	cobalamin synthesis protein
SynWH8101_2159	COG1840	ABC-type Fe3 transport system, periplasmic component
SynWH8101_2163	COG1230	cation diffusion facilitator family transporter
SynWH8101_2164	COG2814	Major facilitator Superfamily
SynWH8101_2166	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SynWH8101_2171	COG0708	Exodeoxyribonuclease III
SynWH8101_2172	COG0277	FAD linked oxidase domain protein
SynWH8101_2173	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SynWH8101_2175	COG1666	GTP binding
SynWH8101_2177	COG0330	HflC and HflK could
SynWH8101_2180	COG0857	belongs to the CobB CobQ family
SynWH8101_2182	COG0300	oxidoreductase activity
SynWH8101_2182	COG3000	fatty acid hydroxylase
SynWH8101_2183	COG0024	Methionine aminopeptidase
SynWH8101_2185	COG0335	large ribosomal subunit rRNA binding
SynWH8101_2190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynWH8101_2195	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynWH8101_2196	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SynWH8101_2199	COG0194	GDP metabolic process
SynWH8101_2201	COG0805	protein transport
SynWH8101_2203	COG0723	plastoquinol--plastocyanin reductase activity
SynWH8101_2204	COG3258	Cytochrome c
SynWH8101_2209	COG0248	Ppx GppA phosphatase
SynWH8101_2210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SynWH8101_2211	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynWH8101_2212	COG1619	proteins homologs of microcin C7 resistance protein MccF
SynWH8101_2213	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SynWH8101_2215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SynWH8101_2216	COG1028	Short-chain dehydrogenase reductase Sdr
SynWH8101_2218	COG0459	protein refolding
SynWH8101_2220	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SynWH8101_2224	COG0109	protoheme IX farnesyltransferase activity
SynWH8101_2225	COG1612	heme a metabolic process
SynWH8101_2227	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SynWH8101_2228	COG1845	cytochrome c oxidase, subunit III
SynWH8101_2235	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SynWH8101_2238	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SynWH8101_2239	COG1007	ATP synthesis coupled electron transport
SynWH8101_2240	COG1136	(ABC) transporter
SynWH8101_2241	COG0745	RESPONSE REGULATOR receiver
SynWH8101_2242	COG0739	heme binding
SynWH8101_2244	COG0436	Aminotransferase
SynWH8101_2245	COG3118	belongs to the thioredoxin family
SynWH8101_2246	COG1842	Phage shock protein A
SynWH8101_2248	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SynWH8101_2249	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_2250	COG0697	spore germination
SynWH8101_2251	COG0616	signal peptide processing
SynWH8101_2254	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SynWH8101_2255	COG0594	ribonuclease P activity
SynWH8101_2257	COG0706	membrane insertase activity
SynWH8101_2259	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SynWH8101_2260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SynWH8101_2261	COG0750	zinc metalloprotease
SynWH8101_2262	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SynWH8101_2263	COG1185	polyribonucleotide nucleotidyltransferase activity
SynWH8101_2266	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SynWH8101_2270	COG2801	Transposase and inactivated derivatives
SynWH8101_2271	COG2801	Transposase and inactivated derivatives
SynWH8101_2275	COG3039	Transposase
SynWH8101_2280	COG0776	regulation of translation
SynWH8101_2281	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SynWH8101_2284	COG2211	Major facilitator Superfamily
SynWH8101_2285	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SynWH8101_2288	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SynWH8101_2289	COG0284	orotidine-5'-phosphate decarboxylase activity
SynWH8101_2290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SynWH8101_2292	COG2197	response regulator
SynWH8101_2295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SynWH8101_2297	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynWH8101_2300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SynWH8101_2301	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SynWH8101_2303	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SynWH8101_2305	COG0151	Belongs to the GarS family
SynWH8101_2306	COG5002	protein histidine kinase activity
SynWH8101_2307	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SynWH8101_2308	COG4251	negative regulation of phosphorylation
SynWH8101_2310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SynWH8101_2311	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SynWH8101_2314	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SynWH8101_2315	COG0217	transcriptional regulatory protein
SynWH8101_2316	COG0363	glucosamine-6-phosphate deaminase activity
SynWH8101_2317	COG2385	sporulation resulting in formation of a cellular spore
SynWH8101_2318	COG1234	tRNA 3'-trailer cleavage
SynWH8101_2319	COG2010	Cytochrome c
SynWH8101_2322	COG2264	protein methyltransferase activity
SynWH8101_2323	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SynWH8101_2327	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SynWH8101_2334	COG0443	Heat shock 70 kDa protein
SynWH8101_2337	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SynWH8101_2338	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SynWH8101_2340	COG0459	protein refolding
SynWH8101_2341	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SynWH8101_2342	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SynWH8101_2343	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SynWH8101_2346	COG0387	Pfam Sodium calcium exchanger
SynWH8101_2347	COG0006	proline dipeptidase activity
SynWH8101_2348	COG1253	flavin adenine dinucleotide binding
SynWH8101_2349	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynWH8101_2350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SynWH8101_2351	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynWH8101_2351	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SynWH8101_2353	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SynWH8101_2355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SynWH8101_2357	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SynWH8101_2358	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SynWH8101_2359	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynWH8101_2360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SynWH8101_2362	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SynWH8101_2363	COG0356	it plays a direct role in the translocation of protons across the membrane
SynWH8101_2365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynWH8101_2366	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynWH8101_2370	COG0772	Belongs to the SEDS family
SynWH8101_2372	COG1333	cytochrome c biogenesis protein
SynWH8101_2373	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SynWH8101_2376	COG0347	Belongs to the P(II) protein family
SynWH8101_2379	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SynWH8101_2381	COG0114	fumarate hydratase activity
SynWH8101_2382	COG4581	dead DEAH box helicase
SynWH8101_2383	COG0385	Bile acid
SynWH8101_2387	COG4106	trans-aconitate 2-methyltransferase activity
SynWH8101_2387	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SynWH8101_2390	COG0484	heat shock protein binding
SynWH8101_2391	COG0357	Ribosomal RNA small subunit methyltransferase G
SynWH8101_2397	COG2223	nitrite transmembrane transporter activity
SynWH8101_2398	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SynWH8101_2400	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynWH8101_2401	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SynWH8101_2402	COG0085	RNA polymerase activity
SynWH8101_2403	COG0084	hydrolase, TatD family'
SynWH8101_2404	COG0268	Binds directly to 16S ribosomal RNA
SynWH8101_2405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SynWH8101_2406	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SynWH8101_2407	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynWH8101_2410	COG0668	transmembrane transport
SynWH8101_2413	COG0641	radical SAM
SynWH8101_2414	COG0779	Required for maturation of 30S ribosomal subunits
SynWH8101_2415	COG0195	Participates in both transcription termination and antitermination
SynWH8101_2417	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SynWH8101_2425	COG2988	succinylglutamate desuccinylase activity
SynWH8101_2426	COG0435	Glutathione S-transferase
SynWH8101_2428	COG0488	(ABC) transporter
SynWH8101_2432	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SynWH8101_2433	COG3842	ATPase activity
SynWH8101_2434	COG1193	negative regulation of DNA recombination
SynWH8101_2440	COG0113	porphobilinogen synthase activity
SynWH8101_2441	COG0484	heat shock protein binding
SynWH8101_2443	COG0659	secondary active sulfate transmembrane transporter activity
SynWH8101_2447	COG0116	Belongs to the methyltransferase superfamily
SynWH8101_2451	COG1196	nuclear chromosome segregation
SynWH8101_2453	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SynWH8101_2456	COG0439	Biotin carboxylase
SynWH8101_2459	COG0515	serine threonine protein kinase
SynWH8101_2463	COG4178	(ABC) transporter
SynWH8101_2464	COG0537	adenosine 5'-monophosphoramidase activity
SynWH8101_2466	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SynWH8101_2469	COG0242	peptide deformylase activity
SynWH8101_2471	COG0235	Class ii aldolase
SynWH8101_2472	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SynWH8101_2475	COG1231	oxidoreductase activity
SynWH8101_2478	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SynWH8101_2479	COG0719	Fe-S assembly protein
SynWH8101_2480	COG0396	ATPase activity
SynWH8101_2481	COG0719	Fe-S assembly protein
SynWH8101_2482	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SynWH8101_2483	COG1830	Aldolase
SynWH8101_2487	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SynWH8101_2496	COG0457	Tetratricopeptide repeat
SynWH8101_2499	COG0033	Phosphoglucomutase
SynWH8101_2501	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SynWH8101_2502	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SynWH8101_2507	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SynWH8101_2508	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SynWH8101_2509	COG0175	sulfate reduction
SynWH8101_2510	COG1252	NADH dehydrogenase
SynWH8101_2511	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SynWH8101_2512	COG0471	metal ion transport
SynWH8101_2512	COG3273	potassium ion transport
SynWH8101_2513	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SynWH8101_2514	COG0569	domain protein
SynWH8101_2515	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SynWH8101_2520	COG0488	(ABC) transporter
SynWH8101_2522	COG3039	Transposase
SynWH8101_2523	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SynWH8101_2526	COG1643	Atp-dependent helicase
SynWH8101_2527	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SynWH8101_2528	COG1570	exodeoxyribonuclease VII activity
SynWH8101_2538	COG0483	inositol monophosphate 1-phosphatase activity
SynWH8101_2541	COG1968	undecaprenyl-diphosphatase activity
SynWH8101_2543	COG1555	photosystem II stabilization
SynWH8101_2544	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SynWH8101_2545	COG4243	Vitamin k epoxide reductase
SynWH8101_2546	COG0668	transmembrane transport
SynWH8101_2547	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SynWH8101_2549	COG1032	radical SAM domain protein
SynWH8101_2561	COG1472	Belongs to the glycosyl hydrolase 3 family
SynWH8101_2562	COG0463	Glycosyl transferase, family 2
SynWH8101_2562	COG0457	Tetratricopeptide repeat
SynWH8101_2563	COG1587	Uroporphyrinogen-III synthase
SynWH8101_2566	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynWH8101_2567	COG0316	Belongs to the HesB IscA family
SynWH8101_2570	COG1090	epimerase
SynWH8101_2574	COG0484	heat shock protein binding
SynWH8101_2575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SynWH8101_2576	COG3659	wide pore channel activity
SynWH8101_2577	COG3659	wide pore channel activity
SynWH8101_2578	COG3659	wide pore channel activity
SynWH8101_2583	COG1122	ATPase activity
SynWH8101_2585	COG0745	RESPONSE REGULATOR receiver
SynWH8101_2587	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SynWH8101_2588	COG2217	Heavy metal translocating P-type atpase
SynWH8101_2589	COG3063	Type IV pilus biogenesis stability protein PilW
SynWH8101_2590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SynWH8101_2592	COG0416	fatty acid biosynthetic process
SynWH8101_2593	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SynWH8101_2594	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SynWH8101_2595	COG0318	PFAM AMP-dependent synthetase and ligase
SynWH8101_2595	COG0204	Acyl-transferase
SynWH8101_2597	COG1214	PFAM Peptidase M22, glycoprotease
SynWH8101_2599	COG0617	tRNA 3'-terminal CCA addition
SynWH8101_2601	COG1562	ergosterol biosynthetic process
SynWH8101_2602	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SynWH8101_2602	COG0493	'glutamate synthase
SynWH8101_2605	COG0583	DNA-binding transcription factor activity
SynWH8101_2607	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SynWH8101_2608	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH8101_2610	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SynWH8101_2612	COG2197	response regulator
SynWH8101_2615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SynWH8101_2616	COG0713	ATP synthesis coupled electron transport
SynWH8101_2619	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SynWH8101_2620	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SynWH8101_2621	COG0372	Belongs to the citrate synthase family
SynWH8101_2625	COG1420	regulation of RNA biosynthetic process
SynWH8101_2626	COG0133	tryptophan synthase activity
SynWH8101_2627	COG0023	Translation Initiation Factor
SynWH8101_2628	COG0529	Catalyzes the synthesis of activated sulfate
SynWH8101_2629	COG0628	permease
SynWH8101_2630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SynWH8101_2632	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SynWH8101_2633	COG0564	pseudouridine synthase activity
SynWH8101_2634	COG0745	RESPONSE REGULATOR receiver
SynWH8101_2636	COG1104	cysteine desulfurase activity
SynWH8101_2640	COG0275	rRNA processing
SynWH8101_2641	COG0649	NAD binding
SynWH8101_2642	COG0824	Thioesterase
SynWH8101_2644	COG0318	PFAM AMP-dependent synthetase and ligase
SynWH8101_2645	COG4948	Mandelate Racemase Muconate Lactonizing
SynWH8101_2646	COG1575	Belongs to the MenA family. Type 1 subfamily
SynWH8101_2648	COG0189	ligase activity
SynWH8101_2649	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SynWH8101_2652	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynWH8101_2654	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SynWH8101_2655	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SynWH8101_2658	COG0252	asparaginase activity
SynWH8101_2659	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynWH8101_2660	COG0018	arginyl-trna synthetase
SynWH8101_2662	COG0157	Belongs to the NadC ModD family
SynWH8101_2664	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SynWH8101_2669	COG4106	trans-aconitate 2-methyltransferase activity
SynWH8101_2670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SynWH8101_2671	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SynWH8101_2672	COG4172	Belongs to the ABC transporter superfamily
SynWH8101_2674	COG0564	pseudouridine synthase activity
SynWH8101_2675	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SynWH8101_2676	COG0589	response to stress
SynWH8101_2677	COG0126	phosphoglycerate kinase activity
SynWH8101_2679	COG2084	Dehydrogenase
SynWH8101_2681	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SynWH8101_2682	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SynWH8101_2687	COG0167	dihydroorotate dehydrogenase activity
SynWH8101_2688	COG0328	RNA-DNA hybrid ribonuclease activity
SynWH8101_2690	COG0222	ribosome binding
SynWH8101_2691	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SynWH8101_2692	COG0081	regulation of translation
SynWH8101_2693	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SynWH8101_2694	COG0250	Participates in transcription elongation, termination and antitermination
SynWH8101_2695	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SynWH8101_2696	COG0542	response to heat
SynWH8101_2697	COG0346	lactoylglutathione lyase activity
SynWH8101_2698	COG0148	phosphopyruvate hydratase activity
SynWH8101_2701	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynWH8101_2704	COG4974	Belongs to the 'phage' integrase family
SynWH8101_2709	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SynWH8101_2710	COG0237	dephospho-CoA kinase activity
SynWH8101_2714	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SynWH8101_2716	COG0105	UTP biosynthetic process
SynWH8101_2719	COG1166	arginine decarboxylase activity
SynWH8101_2723	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SynWH8101_2725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SynWH8101_2728	COG0071	Belongs to the small heat shock protein (HSP20) family
SynWH8101_2730	COG0426	domain, Protein
SynWH8101_2730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynWH8101_2731	COG0426	domain, Protein
SynWH8101_2731	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SynWH8101_2732	COG1773	rubredoxin
SynWH8101_2734	COG1741	Belongs to the pirin family
SynWH8101_2738	COG0509	glycine decarboxylation via glycine cleavage system
SynWH8101_2739	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SynWH8101_2743	COG0359	binds to the 23S rRNA
SynWH8101_2744	COG0305	Participates in initiation and elongation during chromosome replication
SynWH8101_2744	COG1372	Participates in initiation and elongation during chromosome replication
SynWH8101_2744	COG1372	Participates in initiation and elongation during chromosome replication
SynWH8101_2744	COG0305	Participates in initiation and elongation during chromosome replication
SynWH8101_2745	COG0445	tRNA wobble uridine modification
SynWH8101_2753	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SynWH8101_2755	COG0398	Pfam SNARE associated Golgi protein
SynWH8101_2756	COG0668	transmembrane transport
SynWH8101_2757	COG0525	valine-tRNA ligase activity
SynWH8101_2759	COG3264	Mechanosensitive ion channel
SynWH8101_2759	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SynWH8101_2763	COG4221	oxidoreductase activity
SynWH8101_2767	COG3956	TIGRFAM MazG family protein
SynWH8101_2768	COG0412	Dienelactone hydrolase
SynWH8101_2769	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SynWH8101_2771	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SynWH8101_2772	COG0010	Belongs to the arginase family
SynWH8101_2776	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SynWH8101_2777	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_2778	COG0783	Belongs to the Dps family
SynWH8101_2779	COG0504	CTP synthase activity
SynWH8101_2780	COG0602	queuosine metabolic process
SynWH8101_2781	COG4574	serine-type endopeptidase inhibitor activity
SynWH8101_2782	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SynWH8101_2784	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SynWH8101_2785	COG0531	amino acid
SynWH8101_2790	COG0559	Belongs to the binding-protein-dependent transport system permease family
SynWH8101_2792	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SynWH8101_2793	COG0830	nickel cation binding
SynWH8101_2794	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SynWH8101_2795	COG0829	nickel cation binding
SynWH8101_2796	COG0831	urea catabolic process
SynWH8101_2797	COG0832	Belongs to the urease beta subunit family
SynWH8101_2798	COG0804	urea catabolic process
SynWH8101_2800	COG2308	Evidence 4 Homologs of previously reported genes of
SynWH8101_2804	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SynWH8101_2805	COG0746	molybdenum cofactor guanylyltransferase activity
SynWH8101_2806	COG2223	nitrite transmembrane transporter activity
SynWH8101_2807	COG0243	molybdopterin cofactor binding
SynWH8101_2811	COG0315	cyclic pyranopterin monophosphate synthase activity
SynWH8101_2813	COG0314	molybdopterin synthase activity
SynWH8101_2815	COG0521	Mo-molybdopterin cofactor biosynthetic process
SynWH8101_2816	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SynWH8101_2818	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SynWH8101_2820	COG2116	formate transmembrane transporter activity
SynWH8101_2822	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SynWH8101_2824	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SynWH8101_2826	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SynWH8101_2827	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SynWH8101_2828	COG0170	dolichyl monophosphate biosynthetic process
SynWH8101_2830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SynWH8101_2831	COG1049	propionate catabolic process, 2-methylcitrate cycle
SynWH8101_2835	COG0788	formyltetrahydrofolate deformylase activity
SynWH8101_2837	COG2022	thiamine diphosphate biosynthetic process
SynWH8101_2837	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SynWH8101_2839	COG0443	Heat shock 70 kDa protein
SynWH8101_2840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SynWH8101_2842	COG0360	Binds together with S18 to 16S ribosomal RNA
SynWH8101_2844	COG0137	argininosuccinate synthase activity
SynWH8101_2847	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SynWH8101_2852	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SynWH8101_2853	COG0438	transferase activity, transferring glycosyl groups
SynWH8101_2855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SynWH8101_2856	COG0497	DNA recombination
SynWH8101_2857	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SynWH8101_2859	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine