locus-tag	class	description
RNA_25	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SYNW0001	COG0592	DNA-directed DNA polymerase activity
SYNW0003	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYNW0004	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SYNW0005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SYNW0007	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SYNW0010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYNW0011	COG0552	protein localization to endoplasmic reticulum
SYNW0012	COG2208	phosphoserine phosphatase activity
SYNW0013	COG0165	Argininosuccinate lyase
SYNW0014	COG0724	RNA recognition motif
SYNW0015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SYNW0016	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYNW0017	COG2081	HI0933 family
SYNW0022	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SYNW0023	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SYNW0024	COG0484	heat shock protein binding
SYNW0026	COG1162	GTPase activity
SYNW0027	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SYNW0028	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SYNW0029	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SYNW0030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SYNW0031	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SYNW0032	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYNW0033	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SYNW0034	COG0511	ligase activity, forming carbon-carbon bonds
SYNW0035	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SYNW0046	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SYNW0047	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SYNW0047	COG0519	Catalyzes the synthesis of GMP from XMP
SYNW0050	COG0768	penicillin binding
SYNW0051	COG0438	transferase activity, transferring glycosyl groups
SYNW0052	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SYNW0054	COG2022	thiamine diphosphate biosynthetic process
SYNW0057	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SYNW0058	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SYNW0059	COG2385	sporulation resulting in formation of a cellular spore
SYNW0060	COG1215	transferase activity, transferring glycosyl groups
SYNW0063	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SYNW0064	COG0740	serine-type endopeptidase activity
SYNW0065	COG0544	peptidyl-prolyl cis-trans isomerase activity
SYNW0066	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SYNW0067	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SYNW0068	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SYNW0074	COG2082	Precorrin-8x methylmutase
SYNW0075	COG0037	tRNA processing
SYNW0077	COG0556	nucleotide-excision repair
SYNW0078	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SYNW0082	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SYNW0086	COG0653	protein targeting
SYNW0090	COG1045	serine acetyltransferase
SYNW0091	COG1725	Transcriptional regulator
SYNW0092	COG0412	Dienelactone hydrolase
SYNW0093	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SYNW0094	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SYNW0095	COG0187	DNA topoisomerase II activity
SYNW0095	COG1372	Participates in initiation and elongation during chromosome replication
SYNW0097	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SYNW0098	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SYNW0099	COG0386	Belongs to the glutathione peroxidase family
SYNW0101	COG2239	Acts as a magnesium transporter
SYNW0102	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNW0106	COG0714	Associated with various cellular activities
SYNW0107	COG0714	Associated with various cellular activities
SYNW0113	COG2015	COG2015, Alkyl sulfatase and related hydrolases
SYNW0118	COG0802	atpase or kinase
SYNW0119	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SYNW0120	COG0586	Pfam SNARE associated Golgi protein
SYNW0121	COG0629	single-stranded DNA binding
SYNW0126	COG0745	RESPONSE REGULATOR receiver
SYNW0127	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SYNW0131	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SYNW0132	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SYNW0134	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SYNW0135	COG2255	four-way junction helicase activity
SYNW0137	COG1473	amidohydrolase
SYNW0140	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SYNW0141	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SYNW0142	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYNW0143	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYNW0144	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNW0145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SYNW0147	COG0598	Magnesium transport protein CorA
SYNW0149	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SYNW0151	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNW0152	COG0571	ribonuclease III activity
SYNW0155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SYNW0156	COG0058	SHG alpha-glucan phosphorylase activity
SYNW0157	COG0475	glutathione-regulated potassium exporter activity
SYNW0159	COG0596	Alpha beta hydrolase
SYNW0161	COG0277	FAD linked oxidase domain protein
SYNW0163	COG0247	lactate metabolic process
SYNW0166	COG0538	isocitrate dehydrogenase activity
SYNW0167	COG0463	Glycosyl transferase, family 2
SYNW0169	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SYNW0171	COG5398	heme oxygenase
SYNW0173	COG1132	(ABC) transporter
SYNW0174	COG0438	transferase activity, transferring glycosyl groups
SYNW0180	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SYNW0184	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SYNW0186	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SYNW0187	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SYNW0187	COG0517	IMP dehydrogenase activity
SYNW0188	COG0617	tRNA 3'-terminal CCA addition
SYNW0190	COG0709	Synthesizes selenophosphate from selenide and ATP
SYNW0191	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SYNW0193	COG2274	protein secretion by the type I secretion system
SYNW0195	COG0438	transferase activity, transferring glycosyl groups
SYNW0197	COG0124	histidyl-tRNA synthetase
SYNW0198	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYNW0199	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SYNW0205	COG4447	cellulose binding
SYNW0207	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNW0208	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNW0209	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNW0210	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SYNW0213	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYNW0213	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYNW0216	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SYNW0217	COG1132	(ABC) transporter
SYNW0218	COG0494	nUDIX hydrolase
SYNW0219	COG0415	Belongs to the DNA photolyase family
SYNW0225	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SYNW0226	COG0131	Imidazoleglycerol-phosphate dehydratase
SYNW0227	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SYNW0229	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SYNW0234	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SYNW0237	COG0354	folic acid binding
SYNW0238	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SYNW0239	COG1253	flavin adenine dinucleotide binding
SYNW0240	COG0673	inositol 2-dehydrogenase activity
SYNW0244	COG0343	queuine tRNA-ribosyltransferase activity
SYNW0246	COG2205	protein histidine kinase activity
SYNW0249	COG0138	bifunctional purine biosynthesis protein purh
SYNW0252	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SYNW0253	COG0004	ammonium transporteR
SYNW0254	COG1489	DNA binding
SYNW0255	COG0728	peptidoglycan biosynthetic process
SYNW0259	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SYNW0260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYNW0261	COG1546	Belongs to the CinA family
SYNW0261	COG1058	Belongs to the CinA family
SYNW0262	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SYNW0263	COG0066	3-isopropylmalate dehydratase activity
SYNW0270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYNW0271	COG0193	aminoacyl-tRNA hydrolase activity
SYNW0274	COG4372	Transposase
SYNW0276	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SYNW0278	COG0717	Belongs to the dCTP deaminase family
SYNW0280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SYNW0281	COG0741	lytic transglycosylase activity
SYNW0281	COG1196	nuclear chromosome segregation
SYNW0281	COG0739	heme binding
SYNW0282	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SYNW0283	COG2971	BadF BadG BcrA BcrD
SYNW0285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SYNW0289	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SYNW0292	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYNW0293	COG1402	creatininase
SYNW0294	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SYNW0295	COG2094	Belongs to the DNA glycosylase MPG family
SYNW0296	COG0540	Belongs to the ATCase OTCase family
SYNW0301	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SYNW0304	COG0529	Catalyzes the synthesis of activated sulfate
SYNW0304	COG2046	Belongs to the sulfate adenylyltransferase family
SYNW0305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNW0306	COG0800	Aldolase
SYNW0308	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SYNW0314	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNW0318	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SYNW0319	COG0719	Fe-S assembly protein
SYNW0320	COG0396	ATPase activity
SYNW0321	COG0719	Fe-S assembly protein
SYNW0322	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SYNW0324	COG0242	peptide deformylase activity
SYNW0327	COG0606	chelatase, subunit chli
SYNW0328	COG0537	adenosine 5'-monophosphoramidase activity
SYNW0329	COG4178	(ABC) transporter
SYNW0333	COG0515	serine threonine protein kinase
SYNW0336	COG0439	Biotin carboxylase
SYNW0337	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYNW0338	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYNW0341	COG1196	nuclear chromosome segregation
SYNW0346	COG0116	Belongs to the methyltransferase superfamily
SYNW0348	COG1525	nuclease
SYNW0350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SYNW0394	COG2089	acid synthase
SYNW0398	COG1083	cytidylyl-transferase
SYNW0400	COG3562	capsule polysaccharide
SYNW0402	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYNW0405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SYNW0411	COG2274	protein secretion by the type I secretion system
SYNW0421	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SYNW0422	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SYNW0423	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYNW0424	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYNW0425	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SYNW0427	COG1132	(ABC) transporter
SYNW0435	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SYNW0436	COG0107	imidazoleglycerol-phosphate synthase activity
SYNW0439	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNW0444	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SYNW0445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYNW0446	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SYNW0448	COG2089	acid synthase
SYNW0449	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SYNW0450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYNW0453	COG0463	Glycosyl transferase, family 2
SYNW0460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYNW0462	COG0347	Belongs to the P(II) protein family
SYNW0463	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SYNW0471	COG1333	cytochrome c biogenesis protein
SYNW0475	COG0772	Belongs to the SEDS family
SYNW0486	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNW0487	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNW0489	COG0356	it plays a direct role in the translocation of protons across the membrane
SYNW0490	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYNW0492	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYNW0493	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYNW0494	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SYNW0495	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SYNW0497	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SYNW0499	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYNW0500	COG3012	SEC-C Motif Domain Protein
SYNW0502	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SYNW0502	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYNW0503	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SYNW0504	COG1160	GTP binding
SYNW0505	COG1253	flavin adenine dinucleotide binding
SYNW0506	COG0006	proline dipeptidase activity
SYNW0507	COG0387	Pfam Sodium calcium exchanger
SYNW0511	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SYNW0512	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SYNW0513	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SYNW0514	COG0459	protein refolding
SYNW0519	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SYNW0520	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SYNW0523	COG0443	Heat shock 70 kDa protein
SYNW0530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SYNW0533	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SYNW0534	COG2264	protein methyltransferase activity
SYNW0537	COG2010	Cytochrome c
SYNW0538	COG1234	tRNA 3'-trailer cleavage
SYNW0539	COG2385	sporulation resulting in formation of a cellular spore
SYNW0540	COG0363	glucosamine-6-phosphate deaminase activity
SYNW0543	COG0217	transcriptional regulatory protein
SYNW0544	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SYNW0546	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SYNW0547	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SYNW0549	COG4251	negative regulation of phosphorylation
SYNW0550	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SYNW0551	COG5002	protein histidine kinase activity
SYNW0552	COG0151	Belongs to the GarS family
SYNW0554	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SYNW0556	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SYNW0557	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SYNW0559	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYNW0560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYNW0562	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SYNW0566	COG2197	response regulator
SYNW0568	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SYNW0571	COG0284	orotidine-5'-phosphate decarboxylase activity
SYNW0577	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SYNW0582	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SYNW0583	COG2211	Major facilitator Superfamily
SYNW0587	COG0776	regulation of translation
SYNW0588	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SYNW0591	COG1053	succinate dehydrogenase
SYNW0597	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SYNW0598	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SYNW0598	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SYNW0600	COG0195	Participates in both transcription termination and antitermination
SYNW0601	COG0779	Required for maturation of 30S ribosomal subunits
SYNW0604	COG0641	radical SAM
SYNW0608	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNW0609	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SYNW0610	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SYNW0611	COG0268	Binds directly to 16S ribosomal RNA
SYNW0612	COG0084	hydrolase, TatD family'
SYNW0613	COG0085	RNA polymerase activity
SYNW0614	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYNW0615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYNW0617	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SYNW0626	COG0357	Ribosomal RNA small subunit methyltransferase G
SYNW0627	COG0484	heat shock protein binding
SYNW0629	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SYNW0631	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SYNW0635	COG0385	Bile acid
SYNW0636	COG4581	dead DEAH box helicase
SYNW0637	COG0114	fumarate hydratase activity
SYNW0641	COG1216	Glycosyl transferase, family 2
SYNW0641	COG0438	transferase activity, transferring glycosyl groups
SYNW0645	COG0438	transferase activity, transferring glycosyl groups
SYNW0645	COG1216	Glycosyl transferase, family 2
SYNW0646	COG1088	dTDP-glucose 4,6-dehydratase activity
SYNW0652	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SYNW0654	COG1215	transferase activity, transferring glycosyl groups
SYNW0655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SYNW0657	COG1160	GTP binding
SYNW0658	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SYNW0660	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SYNW0661	COG1799	cell septum assembly
SYNW0662	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SYNW0663	COG0438	transferase activity, transferring glycosyl groups
SYNW0665	COG1381	Involved in DNA repair and RecF pathway recombination
SYNW0666	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SYNW0667	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SYNW0668	COG0321	lipoyl(octanoyl) transferase activity
SYNW0669	COG1022	Amp-dependent synthetase and ligase
SYNW0671	COG0508	dehydrogenase complex catalyzes the overall conversion of
SYNW0672	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SYNW0673	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SYNW0679	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYNW0680	COG0440	acetolactate synthase activity
SYNW0681	COG2267	carboxylic ester hydrolase activity
SYNW0684	COG2226	methyltransferase
SYNW0686	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SYNW0687	COG0492	ferredoxin-NADP+ reductase activity
SYNW0692	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SYNW0694	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SYNW0698	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SYNW0699	COG0733	neurotransmitter:sodium symporter activity
SYNW0701	COG0215	cysteine-tRNA ligase activity
SYNW0702	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYNW0702	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYNW0703	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYNW0704	COG0012	GTP binding
SYNW0709	COG4533	DNA binding
SYNW0711	COG0460	homoserine dehydrogenase
SYNW0712	COG2166	iron-sulfur cluster assembly
SYNW0714	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SYNW0715	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SYNW0716	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYNW0719	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SYNW0720	COG2010	Cytochrome c
SYNW0722	COG0742	ribosomal rna small subunit methyltransferase
SYNW0723	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SYNW0724	COG3118	belongs to the thioredoxin family
SYNW0725	COG0516	GMP reductase activity
SYNW0727	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SYNW0728	COG0644	oxidoreductase
SYNW0729	COG1543	Belongs to the glycosyl hydrolase 57 family
SYNW0730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYNW0731	COG0395	ABC-type sugar transport system, permease component
SYNW0735	COG0011	TIGRFAM Protein of
SYNW0737	COG0564	pseudouridine synthase activity
SYNW0738	COG4095	Psort location CytoplasmicMembrane, score
SYNW0739	COG1480	7TM receptor with intracellular HD hydrolase
SYNW0740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SYNW0742	COG0142	geranyltranstransferase activity
SYNW0744	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SYNW0746	COG0406	alpha-ribazole phosphatase activity
SYNW0747	COG1254	Belongs to the acylphosphatase family
SYNW0748	COG1797	cobyrinic acid a,c-diamide synthase activity
SYNW0750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SYNW0751	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SYNW0753	COG2205	protein histidine kinase activity
SYNW0756	COG0308	aminopeptidase N
SYNW0759	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYNW0765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SYNW0767	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNW0771	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SYNW0773	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SYNW0775	COG2197	response regulator
SYNW0776	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SYNW0779	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SYNW0782	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SYNW0783	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYNW0784	COG0473	3-isopropylmalate dehydrogenase activity
SYNW0785	COG3954	Phosphoribulokinase
SYNW0787	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SYNW0788	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SYNW0790	COG0673	inositol 2-dehydrogenase activity
SYNW0791	COG0191	fructose-bisphosphate aldolase activity
SYNW0792	COG1619	proteins homologs of microcin C7 resistance protein MccF
SYNW0793	COG0047	phosphoribosylformylglycinamidine synthase activity
SYNW0794	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYNW0796	COG0668	transmembrane transport
SYNW0798	COG0640	Transcriptional regulator
SYNW0807	COG5002	protein histidine kinase activity
SYNW0808	COG0745	RESPONSE REGULATOR receiver
SYNW0814	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SYNW0817	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYNW0819	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SYNW0820	COG1429	ligase activity, forming nitrogen-metal bonds
SYNW0822	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SYNW0823	COG0149	triose-phosphate isomerase activity
SYNW0824	COG2501	S4 domain
SYNW0825	COG1132	(ABC) transporter
SYNW0828	COG1115	amino acid carrier protein
SYNW0830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SYNW0832	COG0799	negative regulation of ribosome biogenesis
SYNW0839	COG0659	secondary active sulfate transmembrane transporter activity
SYNW0840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SYNW0841	COG4597	amino acid ABC transporter
SYNW0842	COG0765	amino acid transport
SYNW0850	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SYNW0857	COG0625	glutathione transferase activity
SYNW0863	COG1799	cell septum assembly
SYNW0865	COG0735	belongs to the Fur family
SYNW0868	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SYNW0875	COG0259	pyridoxamine-phosphate oxidase activity
SYNW0877	COG0123	including yeast histone deacetylase and acetoin utilization protein
SYNW0882	COG0786	glutamate:sodium symporter activity
SYNW0897	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SYNW0899	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SYNW0904	COG0745	RESPONSE REGULATOR receiver
SYNW0906	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SYNW0907	COG0271	Belongs to the BolA IbaG family
SYNW0910	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SYNW0914	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SYNW0918	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SYNW0920	COG0513	Belongs to the DEAD box helicase family
SYNW0923	COG0724	RNA recognition motif
SYNW0924	COG1132	(ABC) transporter
SYNW0925	COG0589	response to stress
SYNW0925	COG0475	glutathione-regulated potassium exporter activity
SYNW0928	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SYNW0929	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SYNW0933	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SYNW0934	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SYNW0935	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SYNW0936	COG0019	diaminopimelate decarboxylase activity
SYNW0937	COG0456	acetyltransferase
SYNW0938	COG0542	response to heat
SYNW0939	COG0371	Dehydrogenase
SYNW0940	COG0596	Alpha beta hydrolase
SYNW0942	COG0575	Belongs to the CDS family
SYNW0943	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SYNW0944	COG1982	Orn Lys Arg decarboxylase major
SYNW0945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNW0947	COG0745	RESPONSE REGULATOR receiver
SYNW0948	COG5002	protein histidine kinase activity
SYNW0949	COG1187	pseudouridine synthase activity
SYNW0959	COG2274	protein secretion by the type I secretion system
SYNW0962	COG1640	4-alpha-glucanotransferase
SYNW0966	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SYNW0969	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYNW0970	COG1121	(ABC) transporter
SYNW0975	COG0701	Predicted permease
SYNW0996	COG0681	Belongs to the peptidase S26 family
SYNW0997	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SYNW0998	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SYNW0999	COG1376	ErfK ybiS ycfS ynhG family protein
SYNW1000	COG0297	glycogen (starch) synthase activity
SYNW1002	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SYNW1003	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SYNW1005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SYNW1006	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SYNW1007	COG2045	Belongs to the ComB family
SYNW1008	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYNW1009	COG0860	N-Acetylmuramoyl-L-alanine amidase
SYNW1010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SYNW1011	COG0142	geranyltranstransferase activity
SYNW1012	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SYNW1013	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SYNW1015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYNW1016	COG2176	DNA-directed DNA polymerase activity
SYNW1018	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYNW1019	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNW1021	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYNW1023	COG1132	(ABC) transporter
SYNW1025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SYNW1026	COG0505	Belongs to the CarA family
SYNW1028	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SYNW1029	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYNW1031	COG0154	amidase activity
SYNW1032	COG0587	DNA-directed DNA polymerase activity
SYNW1034	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SYNW1035	COG0632	four-way junction helicase activity
SYNW1038	COG0358	DNA primase activity
SYNW1039	COG0798	PFAM Bile acid sodium symporter
SYNW1044	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SYNW1048	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SYNW1051	COG0792	nuclease activity
SYNW1052	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SYNW1053	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SYNW1055	COG0022	dehydrogenase e1 component
SYNW1055	COG0508	dehydrogenase complex catalyzes the overall conversion of
SYNW1056	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYNW1057	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYNW1066	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SYNW1067	COG0515	serine threonine protein kinase
SYNW1073	COG0174	glutamine synthetase
SYNW1075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SYNW1076	COG0590	tRNA wobble adenosine to inosine editing
SYNW1079	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SYNW1083	COG0612	Peptidase, M16
SYNW1089	COG1216	Glycosyl transferase, family 2
SYNW1090	COG0052	Belongs to the universal ribosomal protein uS2 family
SYNW1091	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SYNW1093	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SYNW1094	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SYNW1095	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SYNW1096	COG0751	glycine-tRNA ligase activity
SYNW1097	COG0644	oxidoreductase
SYNW1099	COG0826	peptidase U32
SYNW1114	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SYNW1115	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SYNW1116	COG1494	fructose-1,6-bisphosphatase
SYNW1117	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SYNW1118	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNW1119	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SYNW1120	COG0363	glucosamine-6-phosphate deaminase activity
SYNW1123	COG0129	dihydroxy-acid dehydratase activity
SYNW1125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SYNW1132	COG0300	oxidoreductase activity
SYNW1147	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SYNW1148	COG4106	trans-aconitate 2-methyltransferase activity
SYNW1149	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SYNW1153	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SYNW1158	COG1836	PFAM Integral membrane protein DUF92
SYNW1169	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SYNW1170	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SYNW1171	COG0436	Aminotransferase
SYNW1173	COG1573	uracil-dna glycosylase
SYNW1174	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SYNW1175	COG0793	Belongs to the peptidase S41A family
SYNW1177	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SYNW1191	COG0861	Integral membrane protein TerC family
SYNW1195	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SYNW1197	COG0312	modulator of DNA gyrase
SYNW1198	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SYNW1201	COG0163	prenyltransferase activity
SYNW1202	COG0557	exoribonuclease II activity
SYNW1204	COG2119	membrane
SYNW1206	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SYNW1206	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SYNW1210	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SYNW1211	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNW1212	COG1615	UPF0182 protein
SYNW1213	COG0450	alkyl hydroperoxide reductase
SYNW1214	COG0739	heme binding
SYNW1215	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SYNW1222	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYNW1223	COG0445	tRNA wobble uridine modification
SYNW1224	COG0557	exoribonuclease II activity
SYNW1225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SYNW1226	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SYNW1227	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYNW1227	COG0072	phenylalanine-tRNA ligase activity
SYNW1228	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SYNW1238	COG0646	methionine synthase
SYNW1238	COG1410	methionine synthase
SYNW1239	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SYNW1244	COG3046	protein related to deoxyribodipyrimidine photolyase
SYNW1246	COG0322	excinuclease ABC activity
SYNW1248	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SYNW1250	COG2027	D-alanyl-D-alanine carboxypeptidase
SYNW1254	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SYNW1255	COG0495	leucyl-tRNA aminoacylation
SYNW1256	COG0166	Belongs to the GPI family
SYNW1261	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SYNW1262	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SYNW1263	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYNW1263	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYNW1264	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYNW1265	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SYNW1266	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SYNW1268	COG0484	heat shock protein binding
SYNW1269	COG0443	Heat shock 70 kDa protein
SYNW1270	COG0573	inorganic phosphate transmembrane transporter activity
SYNW1271	COG0581	inorganic phosphate transmembrane transporter activity
SYNW1272	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYNW1274	COG0633	Ferredoxin
SYNW1275	COG0483	inositol monophosphate 1-phosphatase activity
SYNW1276	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SYNW1278	COG0326	Molecular chaperone. Has ATPase activity
SYNW1279	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SYNW1280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYNW1281	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SYNW1282	COG1653	transport
SYNW1285	COG3842	ATPase activity
SYNW1286	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYNW1291	COG0644	oxidoreductase
SYNW1292	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SYNW1293	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SYNW1298	COG0469	pyruvate kinase activity
SYNW1299	COG0577	efflux transmembrane transporter activity
SYNW1299	COG1136	(ABC) transporter
SYNW1300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNW1301	COG0740	serine-type endopeptidase activity
SYNW1304	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SYNW1308	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SYNW1310	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SYNW1321	COG1793	dna ligase
SYNW1322	COG1201	RNA secondary structure unwinding
SYNW1323	COG2059	Chromate
SYNW1330	COG2226	methyltransferase
SYNW1335	COG1119	ATPase activity
SYNW1337	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYNW1340	COG1121	(ABC) transporter
SYNW1341	COG0803	Belongs to the bacterial solute-binding protein 9 family
SYNW1342	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SYNW1343	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SYNW1346	COG4974	Belongs to the 'phage' integrase family
SYNW1364	COG0724	RNA recognition motif
SYNW1380	COG2197	response regulator
SYNW1384	COG0189	ligase activity
SYNW1384	COG4067	protein conserved in archaea
SYNW1385	COG2197	response regulator
SYNW1394	COG0405	Gamma-glutamyltransferase
SYNW1408	COG2124	cytochrome p450
SYNW1412	COG0010	Belongs to the arginase family
SYNW1413	COG0375	protein maturation
SYNW1416	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYNW1417	COG1116	anion transmembrane transporter activity
SYNW1418	COG4638	Rieske (2fe-2S)
SYNW1422	COG2144	transferase activity, transferring acyl groups
SYNW1427	COG2072	flavoprotein involved in K transport
SYNW1430	COG1028	Short-chain dehydrogenase reductase Sdr
SYNW1442	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SYNW1449	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYNW1469	COG0786	glutamate:sodium symporter activity
SYNW1475	COG0180	Tryptophanyl-tRNA synthetase
SYNW1478	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SYNW1480	COG0837	glucose binding
SYNW1481	COG0083	homoserine kinase activity
SYNW1482	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNW1483	COG0339	signal peptide processing
SYNW1486	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SYNW1487	COG1940	carbohydrate kinase activity
SYNW1494	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SYNW1495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SYNW1497	COG3794	PFAM blue (type 1) copper domain protein
SYNW1503	COG0542	response to heat
SYNW1504	COG0720	synthase
SYNW1505	COG0140	phosphoribosyl-ATP diphosphatase activity
SYNW1505	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SYNW1509	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNW1516	COG2010	Cytochrome c
SYNW1519	COG0159	tryptophan synthase activity
SYNW1523	COG0418	dihydroorotase activity
SYNW1524	COG0659	secondary active sulfate transmembrane transporter activity
SYNW1525	COG0530	calcium, potassium:sodium antiporter activity
SYNW1529	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SYNW1530	COG1845	cytochrome c oxidase, subunit III
SYNW1533	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SYNW1535	COG0037	tRNA processing
SYNW1536	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SYNW1537	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNW1540	COG0456	acetyltransferase
SYNW1541	COG1132	(ABC) transporter
SYNW1542	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SYNW1543	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYNW1544	COG3842	ATPase activity
SYNW1545	COG0251	oxidation-reduction process
SYNW1582	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SYNW1586	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SYNW1587	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNW1588	COG2135	peptidase activity
SYNW1589	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNW1590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYNW1590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYNW1599	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYNW1600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SYNW1601	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SYNW1603	COG0196	riboflavin kinase activity
SYNW1604	COG0352	thiamine-phosphate diphosphorylase activity
SYNW1608	COG1691	(AIR) carboxylase
SYNW1610	COG0336	Belongs to the RNA methyltransferase TrmD family
SYNW1613	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SYNW1615	COG0670	Belongs to the BI1 family
SYNW1616	COG1702	phosphate starvation-inducible protein PhoH
SYNW1617	COG0228	four-way junction DNA binding
SYNW1618	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SYNW1620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SYNW1621	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNW1622	COG0482	sulfurtransferase activity
SYNW1623	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SYNW1629	COG0134	indole-3-glycerol-phosphate synthase activity
SYNW1630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SYNW1631	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYNW1633	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SYNW1634	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SYNW1635	COG0285	dihydrofolate synthase activity
SYNW1640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYNW1641	COG1181	Belongs to the D-alanine--D-alanine ligase family
SYNW1644	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SYNW1645	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SYNW1646	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYNW1647	COG4956	integral membrane protein (PIN domain superfamily)
SYNW1648	COG0740	serine-type endopeptidase activity
SYNW1649	COG0740	serine-type endopeptidase activity
SYNW1650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SYNW1651	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SYNW1659	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SYNW1666	COG0582	viral genome integration into host DNA
SYNW1671	COG0752	glycyl-tRNA synthetase alpha subunit
SYNW1674	COG2226	methyltransferase
SYNW1675	COG0107	imidazoleglycerol-phosphate synthase activity
SYNW1677	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SYNW1678	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SYNW1679	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYNW1679	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SYNW1680	COG3695	enzyme binding
SYNW1681	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYNW1684	COG0481	GTPase activity
SYNW1686	COG0579	oxidoreductase
SYNW1687	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SYNW1690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SYNW1693	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SYNW1694	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SYNW1696	COG3239	Fatty acid desaturase
SYNW1702	COG0424	maF-like protein
SYNW1704	COG1492	cobalamin metabolic process
SYNW1710	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNW1711	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYNW1717	COG4451	ribulose bisphosphate carboxylase, small
SYNW1718	COG1850	ribulose-bisphosphate carboxylase activity
SYNW1720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SYNW1723	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SYNW1724	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SYNW1725	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SYNW1730	COG0730	response to heat
SYNW1731	COG0095	Lipoate-protein ligase
SYNW1732	COG0517	IMP dehydrogenase activity
SYNW1732	COG1994	Peptidase M50
SYNW1733	COG0135	phosphoribosylanthranilate isomerase activity
SYNW1734	COG0302	gtp cyclohydrolase
SYNW1735	COG4221	oxidoreductase activity
SYNW1736	COG0825	malonyl-CoA metabolic process
SYNW1737	COG5322	oxidoreductase activity
SYNW1738	COG3396	Phenylacetate-CoA oxygenase
SYNW1740	COG0539	negative regulation of cytoplasmic translation
SYNW1743	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SYNW1746	COG0028	Belongs to the TPP enzyme family
SYNW1747	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYNW1749	COG2226	methyltransferase
SYNW1752	COG0528	UMP kinase activity
SYNW1753	COG0233	cytoplasmic translational termination
SYNW1757	COG0415	Belongs to the DNA photolyase family
SYNW1759	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SYNW1760	COG0768	penicillin binding
SYNW1763	COG0588	phosphoglycerate mutase activity
SYNW1769	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SYNW1771	COG0442	prolyl-tRNA aminoacylation
SYNW1773	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SYNW1774	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SYNW1777	COG0629	single-stranded DNA binding
SYNW1780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SYNW1782	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SYNW1783	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNW1785	COG0181	hydroxymethylbilane synthase activity
SYNW1788	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SYNW1789	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SYNW1793	COG0432	Pfam Uncharacterised protein family UPF0047
SYNW1794	COG2154	pterin-4-alpha-carbinolamine dehydratase
SYNW1795	COG0523	cobalamin synthesis protein
SYNW1797	COG1840	ABC-type Fe3 transport system, periplasmic component
SYNW1802	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SYNW1803	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNW1807	COG0708	Exodeoxyribonuclease III
SYNW1808	COG0277	FAD linked oxidase domain protein
SYNW1809	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SYNW1811	COG0295	cytidine deaminase activity
SYNW1813	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SYNW1815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYNW1816	COG1666	GTP binding
SYNW1819	COG0857	belongs to the CobB CobQ family
SYNW1821	COG3000	fatty acid hydroxylase
SYNW1821	COG0300	oxidoreductase activity
SYNW1822	COG0024	Methionine aminopeptidase
SYNW1824	COG0335	large ribosomal subunit rRNA binding
SYNW1826	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SYNW1830	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SYNW1834	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SYNW1837	COG0194	GDP metabolic process
SYNW1839	COG0805	protein transport
SYNW1841	COG0723	plastoquinol--plastocyanin reductase activity
SYNW1842	COG0739	heme binding
SYNW1843	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SYNW1844	COG2875	Belongs to the precorrin methyltransferase family
SYNW1846	COG0248	Ppx GppA phosphatase
SYNW1847	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SYNW1848	COG1619	proteins homologs of microcin C7 resistance protein MccF
SYNW1849	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SYNW1852	COG1028	Short-chain dehydrogenase reductase Sdr
SYNW1854	COG0459	protein refolding
SYNW1855	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SYNW1859	COG0109	protoheme IX farnesyltransferase activity
SYNW1860	COG1612	heme a metabolic process
SYNW1861	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SYNW1863	COG1845	cytochrome c oxidase, subunit III
SYNW1869	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SYNW1872	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SYNW1873	COG1007	ATP synthesis coupled electron transport
SYNW1874	COG1136	(ABC) transporter
SYNW1874	COG0577	efflux transmembrane transporter activity
SYNW1877	COG0436	Aminotransferase
SYNW1878	COG3118	belongs to the thioredoxin family
SYNW1879	COG1842	Phage shock protein A
SYNW1881	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SYNW1883	COG0697	spore germination
SYNW1884	COG0616	signal peptide processing
SYNW1887	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SYNW1888	COG0594	ribonuclease P activity
SYNW1890	COG0706	membrane insertase activity
SYNW1892	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNW1894	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SYNW1895	COG0750	zinc metalloprotease
SYNW1896	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SYNW1897	COG1185	polyribonucleotide nucleotidyltransferase activity
SYNW1899	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SYNW1913	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SYNW1914	COG2226	methyltransferase
SYNW1916	COG4176	ABC-type proline glycine betaine transport system permease component
SYNW1917	COG2113	Glycine betaine
SYNW1922	COG2988	succinylglutamate desuccinylase activity
SYNW1923	COG0435	Glutathione S-transferase
SYNW1925	COG0488	(ABC) transporter
SYNW1928	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SYNW1929	COG3842	ATPase activity
SYNW1931	COG1193	negative regulation of DNA recombination
SYNW1933	COG0113	porphobilinogen synthase activity
SYNW1934	COG0484	heat shock protein binding
SYNW1935	COG4243	Vitamin k epoxide reductase
SYNW1936	COG0659	secondary active sulfate transmembrane transporter activity
SYNW1938	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SYNW1946	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SYNW1947	COG1611	Belongs to the LOG family
SYNW1953	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SYNW1954	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SYNW1956	COG1012	belongs to the aldehyde dehydrogenase family
SYNW1957	COG1388	LysM domain
SYNW1957	COG0741	lytic transglycosylase activity
SYNW1961	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SYNW1962	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SYNW1963	COG0235	Class ii aldolase
SYNW1964	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SYNW1966	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SYNW1967	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SYNW1968	COG0793	Belongs to the peptidase S41A family
SYNW1969	COG1078	dGTPase activity
SYNW1970	COG0850	regulation of cytokinetic process
SYNW1971	COG2894	cell division
SYNW1972	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SYNW1975	COG0009	L-threonylcarbamoyladenylate synthase
SYNW1976	COG2890	protein-(glutamine-N5) methyltransferase activity
SYNW1977	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYNW1977	COG0758	DNA mediated transformation
SYNW1984	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SYNW1985	COG0539	negative regulation of cytoplasmic translation
SYNW1986	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SYNW1987	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SYNW1988	COG1070	Carbohydrate kinase
SYNW1997	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNW2025	COG1413	lyase activity
SYNW2026	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SYNW2027	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SYNW2027	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SYNW2028	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SYNW2029	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SYNW2031	COG4989	oxidoreductase activity
SYNW2036	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SYNW2040	COG0408	coproporphyrinogen oxidase activity
SYNW2041	COG0489	protein tyrosine kinase activity
SYNW2042	COG0772	Belongs to the SEDS family
SYNW2045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SYNW2047	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SYNW2049	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SYNW2050	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SYNW2051	COG1606	tRNA processing
SYNW2052	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SYNW2057	COG1233	COG1233 Phytoene dehydrogenase and related
SYNW2062	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SYNW2064	COG3854	ATPases associated with a variety of cellular activities
SYNW2067	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SYNW2068	COG0088	Forms part of the polypeptide exit tunnel
SYNW2069	COG0089	rRNA binding
SYNW2070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SYNW2071	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SYNW2072	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SYNW2073	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SYNW2074	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SYNW2075	COG0255	Belongs to the universal ribosomal protein uL29 family
SYNW2076	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SYNW2077	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SYNW2078	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SYNW2079	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SYNW2080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SYNW2081	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SYNW2082	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SYNW2083	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SYNW2084	COG0200	Binds to the 23S rRNA
SYNW2085	COG0201	protein transport
SYNW2086	COG0563	adenylate kinase activity
SYNW2087	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SYNW2088	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SYNW2089	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SYNW2090	COG0202	RNA polymerase activity
SYNW2091	COG0203	ribosomal protein L17
SYNW2092	COG0101	tRNA pseudouridine synthase activity
SYNW2093	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SYNW2094	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SYNW2095	COG0254	rRNA binding
SYNW2096	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SYNW2098	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SYNW2099	COG0582	viral genome integration into host DNA
SYNW2107	COG0653	protein targeting
SYNW2115	COG0463	Glycosyl transferase, family 2
SYNW2123	COG2885	chlorophyll binding
SYNW2124	COG2885	chlorophyll binding
SYNW2128	COG3659	wide pore channel activity
SYNW2130	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SYNW2132	COG0067	glutamate synthase
SYNW2132	COG0070	glutamate synthase
SYNW2132	COG0069	glutamate synthase activity
SYNW2135	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SYNW2136	COG0049	tRNA binding
SYNW2137	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYNW2138	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SYNW2139	COG0051	transcription antitermination factor activity, RNA binding
SYNW2140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SYNW2141	COG2226	methyltransferase
SYNW2142	COG1605	Chorismate mutase
SYNW2142	COG0077	Prephenate dehydratase
SYNW2144	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SYNW2145	COG1530	ribonuclease E activity
SYNW2147	COG0436	Aminotransferase
SYNW2148	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SYNW2154	COG0033	Phosphoglucomutase
SYNW2156	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SYNW2158	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SYNW2162	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYNW2163	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SYNW2164	COG0175	sulfate reduction
SYNW2165	COG1252	NADH dehydrogenase
SYNW2166	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SYNW2167	COG0471	metal ion transport
SYNW2167	COG3273	potassium ion transport
SYNW2168	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SYNW2169	COG0569	domain protein
SYNW2170	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SYNW2175	COG0488	(ABC) transporter
SYNW2176	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNW2179	COG1643	Atp-dependent helicase
SYNW2180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYNW2181	COG1570	exodeoxyribonuclease VII activity
SYNW2182	COG1722	exodeoxyribonuclease VII activity
SYNW2186	COG0483	inositol monophosphate 1-phosphatase activity
SYNW2189	COG1968	undecaprenyl-diphosphatase activity
SYNW2191	COG1555	photosystem II stabilization
SYNW2192	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SYNW2193	COG4243	Vitamin k epoxide reductase
SYNW2194	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYNW2196	COG1032	radical SAM domain protein
SYNW2202	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SYNW2207	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SYNW2208	COG1472	Belongs to the glycosyl hydrolase 3 family
SYNW2209	COG0457	Tetratricopeptide repeat
SYNW2209	COG0463	Glycosyl transferase, family 2
SYNW2210	COG1587	Uroporphyrinogen-III synthase
SYNW2213	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SYNW2214	COG0316	Belongs to the HesB IscA family
SYNW2218	COG1090	epimerase
SYNW2222	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SYNW2223	COG3659	wide pore channel activity
SYNW2224	COG3659	wide pore channel activity
SYNW2227	COG3659	wide pore channel activity
SYNW2234	COG1122	ATPase activity
SYNW2236	COG0745	RESPONSE REGULATOR receiver
SYNW2238	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SYNW2239	COG2217	Heavy metal translocating P-type atpase
SYNW2240	COG3063	Type IV pilus biogenesis stability protein PilW
SYNW2245	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SYNW2247	COG0416	fatty acid biosynthetic process
SYNW2248	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SYNW2249	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SYNW2252	COG1214	PFAM Peptidase M22, glycoprotease
SYNW2254	COG0617	tRNA 3'-terminal CCA addition
SYNW2255	COG0724	RNA recognition motif
SYNW2256	COG1562	ergosterol biosynthetic process
SYNW2257	COG0493	'glutamate synthase
SYNW2257	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SYNW2260	COG0583	DNA-binding transcription factor activity
SYNW2262	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYNW2263	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNW2266	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYNW2268	COG2197	response regulator
SYNW2270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYNW2271	COG0713	ATP synthesis coupled electron transport
SYNW2272	COG0839	Belongs to the complex I subunit 6 family
SYNW2273	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNW2274	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SYNW2275	COG0372	Belongs to the citrate synthase family
SYNW2276	COG2062	phosphohistidine phosphatase, SixA
SYNW2279	COG1420	regulation of RNA biosynthetic process
SYNW2280	COG0133	tryptophan synthase activity
SYNW2282	COG0023	Translation Initiation Factor
SYNW2283	COG0529	Catalyzes the synthesis of activated sulfate
SYNW2284	COG0628	permease
SYNW2285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SYNW2286	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SYNW2287	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNW2288	COG0564	pseudouridine synthase activity
SYNW2289	COG0745	RESPONSE REGULATOR receiver
SYNW2291	COG1104	cysteine desulfurase activity
SYNW2297	COG0275	rRNA processing
SYNW2298	COG0275	rRNA processing
SYNW2299	COG0649	NAD binding
SYNW2301	COG0824	Thioesterase
SYNW2307	COG1575	Belongs to the MenA family. Type 1 subfamily
SYNW2309	COG0189	ligase activity
SYNW2310	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SYNW2313	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SYNW2314	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SYNW2315	COG0512	Glutamine amidotransferase of anthranilate synthase
SYNW2317	COG0252	asparaginase activity
SYNW2318	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYNW2319	COG0018	arginyl-trna synthetase
SYNW2320	COG0157	Belongs to the NadC ModD family
SYNW2322	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYNW2324	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SYNW2325	COG4172	Belongs to the ABC transporter superfamily
SYNW2326	COG0564	pseudouridine synthase activity
SYNW2328	COG0589	response to stress
SYNW2329	COG0126	phosphoglycerate kinase activity
SYNW2333	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SYNW2334	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYNW2337	COG0167	dihydroorotate dehydrogenase activity
SYNW2338	COG0328	RNA-DNA hybrid ribonuclease activity
SYNW2340	COG0222	ribosome binding
SYNW2341	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SYNW2342	COG0081	regulation of translation
SYNW2343	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SYNW2344	COG0250	Participates in transcription elongation, termination and antitermination
SYNW2345	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SYNW2346	COG0542	response to heat
SYNW2347	COG0346	lactoylglutathione lyase activity
SYNW2348	COG0148	phosphopyruvate hydratase activity
SYNW2349	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNW2353	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SYNW2354	COG0237	dephospho-CoA kinase activity
SYNW2356	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYNW2357	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYNW2357	COG2022	thiamine diphosphate biosynthetic process
SYNW2358	COG0105	UTP biosynthetic process
SYNW2359	COG1166	arginine decarboxylase activity
SYNW2360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SYNW2362	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYNW2365	COG0071	Belongs to the small heat shock protein (HSP20) family
SYNW2367	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYNW2367	COG0426	domain, Protein
SYNW2368	COG0426	domain, Protein
SYNW2368	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYNW2370	COG1733	regulation of RNA biosynthetic process
SYNW2372	COG1741	Belongs to the pirin family
SYNW2374	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SYNW2374	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SYNW2375	COG0509	glycine decarboxylation via glycine cleavage system
SYNW2376	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SYNW2378	COG0359	binds to the 23S rRNA
SYNW2379	COG0305	Participates in initiation and elongation during chromosome replication
SYNW2379	COG1372	Participates in initiation and elongation during chromosome replication
SYNW2379	COG1372	Participates in initiation and elongation during chromosome replication
SYNW2379	COG0305	Participates in initiation and elongation during chromosome replication
SYNW2382	COG0445	tRNA wobble uridine modification
SYNW2389	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYNW2392	COG0398	Pfam SNARE associated Golgi protein
SYNW2395	COG1131	(ABC) transporter
SYNW2396	COG0525	valine-tRNA ligase activity
SYNW2400	COG4221	oxidoreductase activity
SYNW2418	COG3956	TIGRFAM MazG family protein
SYNW2420	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SYNW2421	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SYNW2422	COG0010	Belongs to the arginase family
SYNW2425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SYNW2426	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SYNW2427	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNW2428	COG0504	CTP synthase activity
SYNW2429	COG0602	queuosine metabolic process
SYNW2430	COG2084	Dehydrogenase
SYNW2431	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SYNW2435	COG0366	Alpha amylase catalytic
SYNW2436	COG0463	Glycosyl transferase, family 2
SYNW2438	COG0410	ABC transporter
SYNW2441	COG0559	Belongs to the binding-protein-dependent transport system permease family
SYNW2443	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SYNW2444	COG0830	nickel cation binding
SYNW2445	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SYNW2446	COG0829	nickel cation binding
SYNW2447	COG0831	urea catabolic process
SYNW2448	COG0832	Belongs to the urease beta subunit family
SYNW2449	COG0804	urea catabolic process
SYNW2453	COG0367	asparagine synthase
SYNW2454	COG0540	Belongs to the ATCase OTCase family
SYNW2456	COG2308	Evidence 4 Homologs of previously reported genes of
SYNW2460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SYNW2461	COG0746	molybdenum cofactor guanylyltransferase activity
SYNW2462	COG2223	nitrite transmembrane transporter activity
SYNW2463	COG2223	nitrite transmembrane transporter activity
SYNW2464	COG0243	molybdopterin cofactor binding
SYNW2468	COG0315	cyclic pyranopterin monophosphate synthase activity
SYNW2472	COG0314	molybdopterin synthase activity
SYNW2474	COG0521	Mo-molybdopterin cofactor biosynthetic process
SYNW2475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYNW2477	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SYNW2479	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYNW2480	COG1121	(ABC) transporter
SYNW2481	COG0803	Belongs to the bacterial solute-binding protein 9 family
SYNW2482	COG0523	cobalamin synthesis protein
SYNW2485	COG1116	anion transmembrane transporter activity
SYNW2486	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYNW2487	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYNW2487	COG1116	anion transmembrane transporter activity
SYNW2488	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYNW2490	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SYNW2495	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SYNW2496	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNW2497	COG0170	dolichyl monophosphate biosynthetic process
SYNW2499	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SYNW2500	COG1049	propionate catabolic process, 2-methylcitrate cycle
SYNW2504	COG0788	formyltetrahydrofolate deformylase activity
SYNW2506	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYNW2507	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYNW2508	COG0443	Heat shock 70 kDa protein
SYNW2509	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SYNW2511	COG0360	Binds together with S18 to 16S ribosomal RNA
SYNW2513	COG0137	argininosuccinate synthase activity
SYNW2516	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYNW2519	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SYNW2520	COG0438	transferase activity, transferring glycosyl groups
SYNW2522	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SYNW2523	COG0497	DNA recombination
SYNW2524	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNW2526	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine