locus-tag	class	description
SYNGTI_0001	COG0142	geranyltranstransferase activity
SYNGTI_0002	COG1187	pseudouridine synthase activity
SYNGTI_0004	COG0515	serine threonine protein kinase
SYNGTI_0005	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SYNGTI_0006	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYNGTI_0007	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SYNGTI_0009	COG1166	arginine decarboxylase activity
SYNGTI_0010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYNGTI_0012	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SYNGTI_0013	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SYNGTI_0014	COG1120	ATPase activity
SYNGTI_0015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SYNGTI_0017	COG4977	sequence-specific DNA binding
SYNGTI_0022	COG2207	Transcriptional regulator
SYNGTI_0023	COG2226	methyltransferase
SYNGTI_0025	COG0848	biopolymer transport protein
SYNGTI_0026	COG0811	peptide transport
SYNGTI_0029	COG1132	(ABC) transporter
SYNGTI_0032	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SYNGTI_0033	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SYNGTI_0035	COG1132	(ABC) transporter
SYNGTI_0044	COG0409	Hydrogenase expression formation protein
SYNGTI_0045	COG1091	dTDP-4-dehydrorhamnose reductase activity
SYNGTI_0046	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYNGTI_0047	COG0297	glycogen (starch) synthase activity
SYNGTI_0050	COG1131	(ABC) transporter
SYNGTI_0053	COG2318	DinB family
SYNGTI_0057	COG1214	PFAM Peptidase M22, glycoprotease
SYNGTI_0061	COG1615	UPF0182 protein
SYNGTI_0064	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SYNGTI_0065	COG0563	adenylate kinase activity
SYNGTI_0066	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SYNGTI_0068	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYNGTI_0071	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYNGTI_0072	COG0194	GDP metabolic process
SYNGTI_0073	COG0406	alpha-ribazole phosphatase activity
SYNGTI_0075	COG0730	response to heat
SYNGTI_0076	COG1413	lyase activity
SYNGTI_0079	COG0330	HflC and HflK could
SYNGTI_0080	COG1530	ribonuclease E activity
SYNGTI_0081	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SYNGTI_0082	COG0494	nUDIX hydrolase
SYNGTI_0083	COG1185	polyribonucleotide nucleotidyltransferase activity
SYNGTI_0084	COG0681	Belongs to the peptidase S26 family
SYNGTI_0087	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SYNGTI_0089	COG1401	restriction endodeoxyribonuclease activity
SYNGTI_0090	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SYNGTI_0091	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SYNGTI_0100	COG1104	cysteine desulfurase activity
SYNGTI_0105	COG0582	viral genome integration into host DNA
SYNGTI_0107	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYNGTI_0107	COG2022	thiamine diphosphate biosynthetic process
SYNGTI_0110	COG5002	protein histidine kinase activity
SYNGTI_0112	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SYNGTI_0116	COG0704	Plays a role in the regulation of phosphate uptake
SYNGTI_0117	COG0779	Required for maturation of 30S ribosomal subunits
SYNGTI_0118	COG0195	Participates in both transcription termination and antitermination
SYNGTI_0120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SYNGTI_0128	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYNGTI_0130	COG0011	TIGRFAM Protein of
SYNGTI_0131	COG0589	response to stress
SYNGTI_0133	COG0123	including yeast histone deacetylase and acetoin utilization protein
SYNGTI_0134	COG0010	Belongs to the arginase family
SYNGTI_0135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYNGTI_0142	COG2099	Precorrin-6x reductase
SYNGTI_0145	COG1007	ATP synthesis coupled electron transport
SYNGTI_0150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYNGTI_0151	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SYNGTI_0152	COG0426	domain, Protein
SYNGTI_0152	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYNGTI_0154	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYNGTI_0154	COG0426	domain, Protein
SYNGTI_0155	COG0793	Belongs to the peptidase S41A family
SYNGTI_0156	COG0009	L-threonylcarbamoyladenylate synthase
SYNGTI_0157	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SYNGTI_0158	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SYNGTI_0159	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SYNGTI_0160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYNGTI_0161	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYNGTI_0163	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYNGTI_0164	COG0356	it plays a direct role in the translocation of protons across the membrane
SYNGTI_0166	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYNGTI_0169	COG0714	Associated with various cellular activities
SYNGTI_0170	COG0316	Belongs to the HesB IscA family
SYNGTI_0171	COG0697	spore germination
SYNGTI_0173	COG1127	ABC transporter
SYNGTI_0175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SYNGTI_0179	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SYNGTI_0182	COG0163	prenyltransferase activity
SYNGTI_0184	COG0589	response to stress
SYNGTI_0186	COG5001	Diguanylate cyclase
SYNGTI_0186	COG1716	ATPase activity
SYNGTI_0190	COG1234	tRNA 3'-trailer cleavage
SYNGTI_0192	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SYNGTI_0195	COG0631	protein serine/threonine phosphatase activity
SYNGTI_0197	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SYNGTI_0197	COG4451	ribulose bisphosphate carboxylase, small
SYNGTI_0198	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
SYNGTI_0199	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYNGTI_0200	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYNGTI_0201	COG0493	'glutamate synthase
SYNGTI_0211	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYNGTI_0211	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYNGTI_0213	COG1982	Orn Lys Arg decarboxylase major
SYNGTI_0214	COG0686	Belongs to the AlaDH PNT family
SYNGTI_0215	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SYNGTI_0219	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNGTI_0221	COG0673	inositol 2-dehydrogenase activity
SYNGTI_0222	COG0700	Nucleoside recognition
SYNGTI_0223	COG2715	membrane protein required for spore maturation
SYNGTI_0224	COG1640	4-alpha-glucanotransferase
SYNGTI_0226	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SYNGTI_0229	COG2203	Gaf domain
SYNGTI_0229	COG3706	GGDEF domain
SYNGTI_0229	COG4251	negative regulation of phosphorylation
SYNGTI_0229	COG5001	Diguanylate cyclase
SYNGTI_0233	COG0175	sulfate reduction
SYNGTI_0234	COG1420	regulation of RNA biosynthetic process
SYNGTI_0235	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SYNGTI_0236	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SYNGTI_0238	COG0003	Pfam Anion-transporting ATPase
SYNGTI_0239	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYNGTI_0242	COG0484	heat shock protein binding
SYNGTI_0243	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SYNGTI_0245	COG0463	Glycosyl transferase, family 2
SYNGTI_0245	COG1216	Glycosyl transferase, family 2
SYNGTI_0247	COG1605	Chorismate mutase
SYNGTI_0247	COG0077	Prephenate dehydratase
SYNGTI_0248	COG4251	negative regulation of phosphorylation
SYNGTI_0248	COG3706	GGDEF domain
SYNGTI_0248	COG2203	Gaf domain
SYNGTI_0248	COG5001	Diguanylate cyclase
SYNGTI_0250	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SYNGTI_0256	COG0589	response to stress
SYNGTI_0257	COG2226	methyltransferase
SYNGTI_0259	COG0538	isocitrate dehydrogenase activity
SYNGTI_0260	COG4636	protein conserved in cyanobacteria
SYNGTI_0262	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_0265	COG0762	integral membrane protein
SYNGTI_0266	COG1840	ABC-type Fe3 transport system, periplasmic component
SYNGTI_0267	COG0336	Belongs to the RNA methyltransferase TrmD family
SYNGTI_0269	COG0205	6-phosphofructokinase activity
SYNGTI_0270	COG1289	transmembrane transporter activity
SYNGTI_0271	COG1555	photosystem II stabilization
SYNGTI_0273	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SYNGTI_0274	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SYNGTI_0275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SYNGTI_0280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SYNGTI_0281	COG0277	FAD linked oxidase domain protein
SYNGTI_0285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SYNGTI_0287	COG0408	coproporphyrinogen oxidase activity
SYNGTI_0288	COG5398	heme oxygenase
SYNGTI_0290	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SYNGTI_0293	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SYNGTI_0294	COG0672	)-iron permease
SYNGTI_0295	COG0592	DNA-directed DNA polymerase activity
SYNGTI_0296	COG0159	tryptophan synthase activity
SYNGTI_0299	COG0436	Aminotransferase
SYNGTI_0301	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SYNGTI_0304	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SYNGTI_0306	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SYNGTI_0307	COG0701	Predicted permease
SYNGTI_0311	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SYNGTI_0312	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SYNGTI_0313	COG4636	protein conserved in cyanobacteria
SYNGTI_0314	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SYNGTI_0317	COG3206	protein involved in exopolysaccharide biosynthesis
SYNGTI_0317	COG0489	protein tyrosine kinase activity
SYNGTI_0325	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYNGTI_0333	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SYNGTI_0334	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SYNGTI_0335	COG1088	dTDP-glucose 4,6-dehydratase activity
SYNGTI_0336	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNGTI_0339	COG1215	transferase activity, transferring glycosyl groups
SYNGTI_0341	COG1215	transferase activity, transferring glycosyl groups
SYNGTI_0342	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_0347	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNGTI_0352	COG0297	glycogen (starch) synthase activity
SYNGTI_0353	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_0354	COG1598	PFAM Uncharacterised protein family UPF0150
SYNGTI_0356	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SYNGTI_0362	COG0110	maltose O-acetyltransferase activity
SYNGTI_0365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYNGTI_0367	COG3781	membrane
SYNGTI_0368	COG0045	succinate-CoA ligase (ADP-forming) activity
SYNGTI_0369	COG0861	Integral membrane protein TerC family
SYNGTI_0370	COG2268	Band 7 protein
SYNGTI_0371	COG0463	Glycosyl transferase, family 2
SYNGTI_0372	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SYNGTI_0374	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYNGTI_0375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SYNGTI_0376	COG0004	ammonium transporteR
SYNGTI_0377	COG0745	RESPONSE REGULATOR receiver
SYNGTI_0380	COG0737	Belongs to the 5'-nucleotidase family
SYNGTI_0381	COG0529	Catalyzes the synthesis of activated sulfate
SYNGTI_0382	COG0811	peptide transport
SYNGTI_0383	COG0848	biopolymer transport protein
SYNGTI_0384	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYNGTI_0384	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SYNGTI_0386	COG0530	calcium, potassium:sodium antiporter activity
SYNGTI_0390	COG0745	RESPONSE REGULATOR receiver
SYNGTI_0391	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYNGTI_0397	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SYNGTI_0398	COG5001	Diguanylate cyclase
SYNGTI_0398	COG4251	negative regulation of phosphorylation
SYNGTI_0398	COG3706	GGDEF domain
SYNGTI_0398	COG2203	Gaf domain
SYNGTI_0400	COG3273	potassium ion transport
SYNGTI_0400	COG0471	metal ion transport
SYNGTI_0406	COG3854	ATPases associated with a variety of cellular activities
SYNGTI_0407	COG0352	thiamine-phosphate diphosphorylase activity
SYNGTI_0408	COG0434	BtpA family
SYNGTI_0412	COG0564	pseudouridine synthase activity
SYNGTI_0413	COG5001	Diguanylate cyclase
SYNGTI_0413	COG4251	negative regulation of phosphorylation
SYNGTI_0413	COG3706	GGDEF domain
SYNGTI_0413	COG2203	Gaf domain
SYNGTI_0415	COG0475	glutathione-regulated potassium exporter activity
SYNGTI_0421	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SYNGTI_0422	COG1733	regulation of RNA biosynthetic process
SYNGTI_0423	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SYNGTI_0431	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SYNGTI_0434	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNGTI_0436	COG1487	ribonuclease activity
SYNGTI_0439	COG2361	Protein of unknown function DUF86
SYNGTI_0442	COG0069	glutamate synthase activity
SYNGTI_0442	COG0070	glutamate synthase
SYNGTI_0442	COG0067	glutamate synthase
SYNGTI_0445	COG2133	pyrroloquinoline quinone binding
SYNGTI_0446	COG1797	cobyrinic acid a,c-diamide synthase activity
SYNGTI_0447	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SYNGTI_0448	COG1022	Amp-dependent synthetase and ligase
SYNGTI_0449	COG0784	Response regulator, receiver
SYNGTI_0452	COG2203	Gaf domain
SYNGTI_0452	COG0840	transmembrane signaling receptor activity
SYNGTI_0453	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SYNGTI_0454	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYNGTI_0455	COG5001	Diguanylate cyclase
SYNGTI_0455	COG4251	negative regulation of phosphorylation
SYNGTI_0455	COG2203	Gaf domain
SYNGTI_0455	COG3706	GGDEF domain
SYNGTI_0456	COG0419	ATPase involved in DNA repair
SYNGTI_0457	COG0484	heat shock protein binding
SYNGTI_0458	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SYNGTI_0460	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SYNGTI_0464	COG1429	ligase activity, forming nitrogen-metal bonds
SYNGTI_0467	COG3956	TIGRFAM MazG family protein
SYNGTI_0469	COG5002	protein histidine kinase activity
SYNGTI_0474	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SYNGTI_0477	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SYNGTI_0478	COG1247	-acetyltransferase
SYNGTI_0479	COG0174	glutamine synthetase
SYNGTI_0481	COG2203	Gaf domain
SYNGTI_0481	COG4251	negative regulation of phosphorylation
SYNGTI_0481	COG3706	GGDEF domain
SYNGTI_0481	COG5001	Diguanylate cyclase
SYNGTI_0483	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SYNGTI_0484	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SYNGTI_0487	COG2310	stress, protein
SYNGTI_0488	COG0076	glutamate decarboxylase activity
SYNGTI_0491	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYNGTI_0492	COG0829	nickel cation binding
SYNGTI_0495	COG1045	serine acetyltransferase
SYNGTI_0498	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SYNGTI_0501	COG0271	Belongs to the BolA IbaG family
SYNGTI_0502	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SYNGTI_0503	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SYNGTI_0507	COG0804	urea catabolic process
SYNGTI_0510	COG1357	PFAM Pentapeptide repeats (8 copies)
SYNGTI_0514	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SYNGTI_0515	COG1773	rubredoxin
SYNGTI_0516	COG4447	cellulose binding
SYNGTI_0521	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SYNGTI_0523	COG3385	transposase activity
SYNGTI_0527	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SYNGTI_0528	COG0784	Response regulator, receiver
SYNGTI_0529	COG3228	Belongs to the MtfA family
SYNGTI_0536	COG1121	(ABC) transporter
SYNGTI_0537	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYNGTI_0540	COG1702	phosphate starvation-inducible protein PhoH
SYNGTI_0543	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNGTI_0547	COG0484	heat shock protein binding
SYNGTI_0548	COG0443	Heat shock 70 kDa protein
SYNGTI_0549	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SYNGTI_0554	COG3659	wide pore channel activity
SYNGTI_0556	COG0860	N-Acetylmuramoyl-L-alanine amidase
SYNGTI_0556	COG2247	cell wall binding repeat
SYNGTI_0568	COG0768	penicillin binding
SYNGTI_0570	COG0247	lactate metabolic process
SYNGTI_0572	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNGTI_0574	COG0583	DNA-binding transcription factor activity
SYNGTI_0576	COG0384	phenazine biosynthesis protein PhzF
SYNGTI_0577	COG2319	Wd-40 repeat
SYNGTI_0578	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYNGTI_0583	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SYNGTI_0583	COG0475	glutathione-regulated potassium exporter activity
SYNGTI_0584	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SYNGTI_0588	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SYNGTI_0589	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SYNGTI_0591	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYNGTI_0592	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SYNGTI_0595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SYNGTI_0596	COG0629	single-stranded DNA binding
SYNGTI_0599	COG0668	transmembrane transport
SYNGTI_0601	COG0745	RESPONSE REGULATOR receiver
SYNGTI_0602	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYNGTI_0602	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SYNGTI_0603	COG3937	granule-associated protein
SYNGTI_0606	COG2226	methyltransferase
SYNGTI_0608	COG0681	Belongs to the peptidase S26 family
SYNGTI_0610	COG1271	oxidase subunit
SYNGTI_0611	COG1294	oxidase, subunit
SYNGTI_0612	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SYNGTI_0613	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SYNGTI_0614	COG0412	Dienelactone hydrolase
SYNGTI_0624	COG2203	Gaf domain
SYNGTI_0624	COG0840	transmembrane signaling receptor activity
SYNGTI_0627	COG0784	Response regulator, receiver
SYNGTI_0628	COG0557	exoribonuclease II activity
SYNGTI_0630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNGTI_0633	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SYNGTI_0635	COG5002	protein histidine kinase activity
SYNGTI_0636	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
SYNGTI_0637	COG1309	transcriptional regulator
SYNGTI_0642	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SYNGTI_0644	COG2385	sporulation resulting in formation of a cellular spore
SYNGTI_0646	COG3411	Ferredoxin
SYNGTI_0647	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYNGTI_0652	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SYNGTI_0653	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SYNGTI_0654	COG0237	dephospho-CoA kinase activity
SYNGTI_0655	COG0237	dephospho-CoA kinase activity
SYNGTI_0660	COG0515	serine threonine protein kinase
SYNGTI_0661	COG0515	serine threonine protein kinase
SYNGTI_0663	COG2988	succinylglutamate desuccinylase activity
SYNGTI_0664	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYNGTI_0666	COG0739	heme binding
SYNGTI_0667	COG0587	DNA-directed DNA polymerase activity
SYNGTI_0670	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SYNGTI_0676	COG1006	Multisubunit Na H antiporter MnhC subunit
SYNGTI_0691	COG1132	(ABC) transporter
SYNGTI_0692	COG3063	Type IV pilus biogenesis stability protein PilW
SYNGTI_0693	COG2217	Heavy metal translocating P-type atpase
SYNGTI_0694	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SYNGTI_0695	COG0745	RESPONSE REGULATOR receiver
SYNGTI_0697	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYNGTI_0698	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SYNGTI_0700	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SYNGTI_0706	COG0557	exoribonuclease II activity
SYNGTI_0708	COG2208	phosphoserine phosphatase activity
SYNGTI_0709	COG0165	Argininosuccinate lyase
SYNGTI_0710	COG2816	NAD+ diphosphatase activity
SYNGTI_0713	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SYNGTI_0714	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SYNGTI_0715	COG1845	cytochrome c oxidase, subunit III
SYNGTI_0716	COG3118	belongs to the thioredoxin family
SYNGTI_0718	COG1116	anion transmembrane transporter activity
SYNGTI_0719	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYNGTI_0722	COG0375	protein maturation
SYNGTI_0723	COG0010	Belongs to the arginase family
SYNGTI_0725	COG3706	GGDEF domain
SYNGTI_0726	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYNGTI_0727	COG0495	leucyl-tRNA aminoacylation
SYNGTI_0728	COG0786	glutamate:sodium symporter activity
SYNGTI_0730	COG2205	protein histidine kinase activity
SYNGTI_0732	COG1132	(ABC) transporter
SYNGTI_0736	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SYNGTI_0737	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYNGTI_0738	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYNGTI_0743	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SYNGTI_0744	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SYNGTI_0746	COG0254	rRNA binding
SYNGTI_0747	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SYNGTI_0748	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SYNGTI_0749	COG0101	tRNA pseudouridine synthase activity
SYNGTI_0750	COG0203	ribosomal protein L17
SYNGTI_0751	COG0202	RNA polymerase activity
SYNGTI_0752	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SYNGTI_0753	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SYNGTI_0754	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SYNGTI_0755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SYNGTI_0756	COG0563	adenylate kinase activity
SYNGTI_0757	COG0201	protein transport
SYNGTI_0758	COG0200	Binds to the 23S rRNA
SYNGTI_0759	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SYNGTI_0760	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SYNGTI_0761	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SYNGTI_0762	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SYNGTI_0763	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SYNGTI_0764	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SYNGTI_0765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SYNGTI_0766	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SYNGTI_0767	COG0255	Belongs to the universal ribosomal protein uL29 family
SYNGTI_0768	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SYNGTI_0769	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SYNGTI_0770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SYNGTI_0771	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SYNGTI_0772	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SYNGTI_0773	COG0089	rRNA binding
SYNGTI_0774	COG0088	Forms part of the polypeptide exit tunnel
SYNGTI_0775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SYNGTI_0776	COG0783	Belongs to the Dps family
SYNGTI_0780	COG2010	Cytochrome c
SYNGTI_0782	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SYNGTI_0783	COG0830	nickel cation binding
SYNGTI_0785	COG1131	(ABC) transporter
SYNGTI_0790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYNGTI_0791	COG0085	RNA polymerase activity
SYNGTI_0792	COG0084	hydrolase, TatD family'
SYNGTI_0793	COG0268	Binds directly to 16S ribosomal RNA
SYNGTI_0794	COG5002	protein histidine kinase activity
SYNGTI_0796	COG0210	DNA helicase
SYNGTI_0796	COG0210	DNA helicase
SYNGTI_0797	COG1196	nuclear chromosome segregation
SYNGTI_0798	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SYNGTI_0802	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYNGTI_0802	COG0758	DNA mediated transformation
SYNGTI_0803	COG0393	Putative heavy-metal-binding
SYNGTI_0805	COG0450	alkyl hydroperoxide reductase
SYNGTI_0806	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SYNGTI_0807	COG0559	Belongs to the binding-protein-dependent transport system permease family
SYNGTI_0809	COG1175	transmembrane transport
SYNGTI_0811	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNGTI_0816	COG1028	Short-chain dehydrogenase reductase Sdr
SYNGTI_0816	COG3347	Dehydrogenase
SYNGTI_0820	COG5001	Diguanylate cyclase
SYNGTI_0820	COG4251	negative regulation of phosphorylation
SYNGTI_0820	COG3706	GGDEF domain
SYNGTI_0820	COG2203	Gaf domain
SYNGTI_0821	COG0745	RESPONSE REGULATOR receiver
SYNGTI_0822	COG0784	Response regulator, receiver
SYNGTI_0824	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SYNGTI_0825	COG2239	Acts as a magnesium transporter
SYNGTI_0831	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SYNGTI_0832	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SYNGTI_0833	COG1799	cell septum assembly
SYNGTI_0834	COG0662	Cupin 2, conserved barrel domain protein
SYNGTI_0834	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SYNGTI_0836	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SYNGTI_0837	COG0459	protein refolding
SYNGTI_0841	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SYNGTI_0842	COG0222	ribosome binding
SYNGTI_0843	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SYNGTI_0844	COG0081	regulation of translation
SYNGTI_0845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SYNGTI_0846	COG0250	Participates in transcription elongation, termination and antitermination
SYNGTI_0847	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SYNGTI_0848	COG0335	large ribosomal subunit rRNA binding
SYNGTI_0854	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SYNGTI_0856	COG3243	poly(R)-hydroxyalkanoic acid synthase
SYNGTI_0858	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SYNGTI_0860	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_0861	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYNGTI_0863	COG2885	chlorophyll binding
SYNGTI_0864	COG2885	chlorophyll binding
SYNGTI_0866	COG1132	(ABC) transporter
SYNGTI_0868	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_0870	COG0745	RESPONSE REGULATOR receiver
SYNGTI_0871	COG0508	dehydrogenase complex catalyzes the overall conversion of
SYNGTI_0871	COG0022	dehydrogenase e1 component
SYNGTI_0872	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYNGTI_0873	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SYNGTI_0874	COG1929	Belongs to the glycerate kinase type-1 family
SYNGTI_0875	COG3659	wide pore channel activity
SYNGTI_0876	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SYNGTI_0877	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SYNGTI_0878	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SYNGTI_0884	COG0776	regulation of translation
SYNGTI_0887	COG0514	ATP-dependent DNA helicase (RecQ)
SYNGTI_0889	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SYNGTI_0890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYNGTI_0892	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SYNGTI_0900	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_0901	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYNGTI_0902	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SYNGTI_0903	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNGTI_0906	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SYNGTI_0907	COG0242	peptide deformylase activity
SYNGTI_0909	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SYNGTI_0914	COG0243	molybdopterin cofactor binding
SYNGTI_0915	COG1116	anion transmembrane transporter activity
SYNGTI_0916	COG1116	anion transmembrane transporter activity
SYNGTI_0916	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYNGTI_0917	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYNGTI_0918	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYNGTI_0921	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SYNGTI_0922	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SYNGTI_0924	COG0793	Belongs to the peptidase S41A family
SYNGTI_0926	COG0275	rRNA processing
SYNGTI_0928	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SYNGTI_0933	COG1090	epimerase
SYNGTI_0935	COG0515	serine threonine protein kinase
SYNGTI_0937	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SYNGTI_0938	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SYNGTI_0939	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SYNGTI_0940	COG0659	secondary active sulfate transmembrane transporter activity
SYNGTI_0941	COG0589	response to stress
SYNGTI_0942	COG1233	COG1233 Phytoene dehydrogenase and related
SYNGTI_0945	COG1053	succinate dehydrogenase
SYNGTI_0946	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SYNGTI_0947	COG0537	adenosine 5'-monophosphoramidase activity
SYNGTI_0953	COG0402	S-adenosylhomocysteine deaminase activity
SYNGTI_0956	COG2267	carboxylic ester hydrolase activity
SYNGTI_0958	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SYNGTI_0959	COG0189	ligase activity
SYNGTI_0961	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SYNGTI_0962	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SYNGTI_0966	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SYNGTI_0967	COG0312	modulator of DNA gyrase
SYNGTI_0971	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SYNGTI_0973	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SYNGTI_0973	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SYNGTI_0976	COG2140	Oxalate decarboxylase
SYNGTI_0977	COG0058	SHG alpha-glucan phosphorylase activity
SYNGTI_0981	COG0515	serine threonine protein kinase
SYNGTI_0984	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SYNGTI_0984	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SYNGTI_0985	COG4999	Histidine kinase
SYNGTI_0985	COG2205	protein histidine kinase activity
SYNGTI_0985	COG3437	response regulator, receiver
SYNGTI_0985	COG3850	Histidine kinase
SYNGTI_0991	COG0546	phosphoglycolate phosphatase activity
SYNGTI_0992	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SYNGTI_0993	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SYNGTI_0995	COG0501	Belongs to the peptidase M48B family
SYNGTI_0996	COG0539	negative regulation of cytoplasmic translation
SYNGTI_0998	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SYNGTI_0999	COG1132	(ABC) transporter
SYNGTI_1000	COG0469	pyruvate kinase activity
SYNGTI_1004	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SYNGTI_1005	COG1268	BioY protein
SYNGTI_1006	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SYNGTI_1009	COG3659	wide pore channel activity
SYNGTI_1012	COG0058	SHG alpha-glucan phosphorylase activity
SYNGTI_1014	COG0575	Belongs to the CDS family
SYNGTI_1019	COG1970	mechanosensitive ion channel activity
SYNGTI_1020	COG0632	four-way junction helicase activity
SYNGTI_1021	COG1836	PFAM Integral membrane protein DUF92
SYNGTI_1022	COG0446	pyridine nucleotide-disulphide oxidoreductase
SYNGTI_1023	COG0724	RNA recognition motif
SYNGTI_1024	COG0154	amidase activity
SYNGTI_1025	COG0739	heme binding
SYNGTI_1026	COG0509	glycine decarboxylation via glycine cleavage system
SYNGTI_1029	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYNGTI_1033	COG1316	TRANSCRIPTIONal
SYNGTI_1035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SYNGTI_1037	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SYNGTI_1038	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SYNGTI_1040	COG1028	Short-chain dehydrogenase reductase Sdr
SYNGTI_1043	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNGTI_1046	COG0322	excinuclease ABC activity
SYNGTI_1051	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SYNGTI_1053	COG3258	Cytochrome c
SYNGTI_1054	COG0723	plastoquinol--plastocyanin reductase activity
SYNGTI_1059	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SYNGTI_1064	COG2319	Wd-40 repeat
SYNGTI_1065	COG2319	Wd-40 repeat
SYNGTI_1069	COG1082	Xylose isomerase domain protein TIM barrel
SYNGTI_1072	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SYNGTI_1077	COG1366	Belongs to the anti-sigma-factor antagonist family
SYNGTI_1080	COG2208	phosphoserine phosphatase activity
SYNGTI_1080	COG2770	Histidine kinase
SYNGTI_1086	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SYNGTI_1087	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SYNGTI_1092	COG1741	Belongs to the pirin family
SYNGTI_1094	COG1193	negative regulation of DNA recombination
SYNGTI_1095	COG0631	protein serine/threonine phosphatase activity
SYNGTI_1096	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNGTI_1097	COG3937	granule-associated protein
SYNGTI_1101	COG1181	Belongs to the D-alanine--D-alanine ligase family
SYNGTI_1102	COG3932	Exopolysaccharide synthesis, ExoD
SYNGTI_1103	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SYNGTI_1105	COG0360	Binds together with S18 to 16S ribosomal RNA
SYNGTI_1106	COG0179	Fumarylacetoacetate (FAA) hydrolase
SYNGTI_1107	COG1413	lyase activity
SYNGTI_1108	COG0641	radical SAM
SYNGTI_1115	COG0083	homoserine kinase activity
SYNGTI_1117	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SYNGTI_1118	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_1120	COG0196	riboflavin kinase activity
SYNGTI_1124	COG0180	Tryptophanyl-tRNA synthetase
SYNGTI_1126	COG1713	HD superfamily hydrolase involved in NAD metabolism
SYNGTI_1127	COG0799	negative regulation of ribosome biogenesis
SYNGTI_1129	COG0181	hydroxymethylbilane synthase activity
SYNGTI_1130	COG0427	acetyl-CoA hydrolase
SYNGTI_1131	COG0280	phosphate acetyltransferase
SYNGTI_1131	COG0857	belongs to the CobB CobQ family
SYNGTI_1133	COG1489	DNA binding
SYNGTI_1135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNGTI_1136	COG0602	queuosine metabolic process
SYNGTI_1137	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SYNGTI_1138	COG0612	Peptidase, M16
SYNGTI_1139	COG0612	Peptidase, M16
SYNGTI_1141	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SYNGTI_1144	COG0187	DNA topoisomerase II activity
SYNGTI_1144	COG1372	Participates in initiation and elongation during chromosome replication
SYNGTI_1147	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SYNGTI_1147	COG0646	methionine synthase
SYNGTI_1149	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SYNGTI_1154	COG1028	Short-chain dehydrogenase reductase Sdr
SYNGTI_1156	COG2197	response regulator
SYNGTI_1157	COG4251	negative regulation of phosphorylation
SYNGTI_1157	COG5001	Diguanylate cyclase
SYNGTI_1157	COG3706	GGDEF domain
SYNGTI_1157	COG2203	Gaf domain
SYNGTI_1159	COG0616	signal peptide processing
SYNGTI_1161	COG0596	Alpha beta hydrolase
SYNGTI_1162	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SYNGTI_1164	COG0747	negative chemotaxis
SYNGTI_1166	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYNGTI_1174	COG4968	Prepilin-type N-terminal cleavage methylation domain
SYNGTI_1175	COG4968	Prepilin-type N-terminal cleavage methylation domain
SYNGTI_1180	COG1357	PFAM Pentapeptide repeats (8 copies)
SYNGTI_1181	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNGTI_1182	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SYNGTI_1184	COG2199	diguanylate cyclase activity
SYNGTI_1185	COG0750	zinc metalloprotease
SYNGTI_1186	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SYNGTI_1188	COG0590	tRNA wobble adenosine to inosine editing
SYNGTI_1190	COG0415	Belongs to the DNA photolyase family
SYNGTI_1192	COG3429	Glucose-6-phosphate dehydrogenase subunit
SYNGTI_1192	COG3409	Peptidoglycan-binding domain 1 protein
SYNGTI_1194	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SYNGTI_1195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SYNGTI_1197	COG1122	ATPase activity
SYNGTI_1198	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SYNGTI_1200	COG0678	peroxiredoxin activity
SYNGTI_1207	COG1252	NADH dehydrogenase
SYNGTI_1209	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SYNGTI_1214	COG0415	Belongs to the DNA photolyase family
SYNGTI_1217	COG1595	DNA-templated transcription, initiation
SYNGTI_1225	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SYNGTI_1227	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SYNGTI_1228	COG3339	Conserved Protein
SYNGTI_1230	COG0312	modulator of DNA gyrase
SYNGTI_1231	COG0482	sulfurtransferase activity
SYNGTI_1234	COG0488	(ABC) transporter
SYNGTI_1235	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SYNGTI_1237	COG0284	orotidine-5'-phosphate decarboxylase activity
SYNGTI_1245	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SYNGTI_1247	COG0697	spore germination
SYNGTI_1254	COG0583	DNA-binding transcription factor activity
SYNGTI_1260	COG2814	Major facilitator Superfamily
SYNGTI_1261	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYNGTI_1262	COG0573	inorganic phosphate transmembrane transporter activity
SYNGTI_1263	COG0581	inorganic phosphate transmembrane transporter activity
SYNGTI_1264	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYNGTI_1265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYNGTI_1266	COG2154	pterin-4-alpha-carbinolamine dehydratase
SYNGTI_1271	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SYNGTI_1271	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SYNGTI_1272	COG1562	ergosterol biosynthetic process
SYNGTI_1273	COG3788	relative of glutathione S-transferase, MAPEG superfamily
SYNGTI_1274	COG0831	urea catabolic process
SYNGTI_1275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SYNGTI_1279	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SYNGTI_1280	COG0730	response to heat
SYNGTI_1282	COG2188	Transcriptional regulator
SYNGTI_1285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYNGTI_1286	COG0640	Transcriptional regulator
SYNGTI_1287	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SYNGTI_1288	COG1754	DNA topoisomerase type I activity
SYNGTI_1288	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SYNGTI_1295	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
SYNGTI_1301	COG2264	protein methyltransferase activity
SYNGTI_1302	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SYNGTI_1305	COG0386	Belongs to the glutathione peroxidase family
SYNGTI_1306	COG0183	Belongs to the thiolase family
SYNGTI_1307	COG1028	Short-chain dehydrogenase reductase Sdr
SYNGTI_1309	COG2205	protein histidine kinase activity
SYNGTI_1309	COG3850	Histidine kinase
SYNGTI_1309	COG4999	Histidine kinase
SYNGTI_1309	COG3437	response regulator, receiver
SYNGTI_1313	COG4242	Belongs to the peptidase S51 family
SYNGTI_1314	COG0189	ligase activity
SYNGTI_1314	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SYNGTI_1320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYNGTI_1321	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYNGTI_1323	COG0285	dihydrofolate synthase activity
SYNGTI_1327	COG4636	protein conserved in cyanobacteria
SYNGTI_1329	COG1606	tRNA processing
SYNGTI_1331	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SYNGTI_1332	COG2045	Belongs to the ComB family
SYNGTI_1333	COG0778	Nitroreductase
SYNGTI_1334	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SYNGTI_1336	COG0516	GMP reductase activity
SYNGTI_1337	COG0395	ABC-type sugar transport system, permease component
SYNGTI_1338	COG3268	Saccharopine dehydrogenase
SYNGTI_1341	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYNGTI_1342	COG1121	(ABC) transporter
SYNGTI_1343	COG0803	Belongs to the bacterial solute-binding protein 9 family
SYNGTI_1345	COG4251	negative regulation of phosphorylation
SYNGTI_1346	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SYNGTI_1348	COG0583	DNA-binding transcription factor activity
SYNGTI_1349	COG0025	NhaP-type Na H and K H
SYNGTI_1350	COG2197	response regulator
SYNGTI_1351	COG5002	protein histidine kinase activity
SYNGTI_1352	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SYNGTI_1353	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SYNGTI_1355	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SYNGTI_1356	COG2205	protein histidine kinase activity
SYNGTI_1358	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SYNGTI_1362	COG2385	sporulation resulting in formation of a cellular spore
SYNGTI_1363	COG0649	NAD binding
SYNGTI_1366	COG0429	hydrolase of the alpha beta-hydrolase fold
SYNGTI_1368	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SYNGTI_1369	COG3536	Protein conserved in bacteria
SYNGTI_1370	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
SYNGTI_1371	COG0716	FMN binding
SYNGTI_1373	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SYNGTI_1374	COG0012	GTP binding
SYNGTI_1375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SYNGTI_1386	COG3842	ATPase activity
SYNGTI_1388	COG1840	ABC-type Fe3 transport system, periplasmic component
SYNGTI_1389	COG0222	ribosome binding
SYNGTI_1391	COG2066	Belongs to the glutaminase family
SYNGTI_1395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SYNGTI_1398	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SYNGTI_1399	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SYNGTI_1400	COG1333	cytochrome c biogenesis protein
SYNGTI_1402	COG1657	PFAM Prenyltransferase squalene oxidase
SYNGTI_1410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SYNGTI_1412	COG1494	fructose-1,6-bisphosphatase
SYNGTI_1415	COG2346	COG2346, Truncated hemoglobins
SYNGTI_1416	COG2205	protein histidine kinase activity
SYNGTI_1416	COG3437	response regulator, receiver
SYNGTI_1416	COG3850	Histidine kinase
SYNGTI_1416	COG4999	Histidine kinase
SYNGTI_1418	COG3437	response regulator, receiver
SYNGTI_1419	COG1917	Cupin 2, conserved barrel domain protein
SYNGTI_1420	COG0552	protein localization to endoplasmic reticulum
SYNGTI_1422	COG0784	Response regulator, receiver
SYNGTI_1422	COG2205	protein histidine kinase activity
SYNGTI_1422	COG5002	protein histidine kinase activity
SYNGTI_1423	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SYNGTI_1425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SYNGTI_1429	COG0667	Aldo Keto reductase
SYNGTI_1430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNGTI_1432	COG0442	prolyl-tRNA aminoacylation
SYNGTI_1434	COG4372	Transposase
SYNGTI_1435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNGTI_1439	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_1440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SYNGTI_1441	COG0416	fatty acid biosynthetic process
SYNGTI_1442	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SYNGTI_1445	COG0347	Belongs to the P(II) protein family
SYNGTI_1446	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYNGTI_1451	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SYNGTI_1452	COG0473	3-isopropylmalate dehydrogenase activity
SYNGTI_1454	COG1575	Belongs to the MenA family. Type 1 subfamily
SYNGTI_1456	COG0656	L-ascorbic acid biosynthetic process
SYNGTI_1463	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SYNGTI_1465	COG2161	toxin-antitoxin pair type II binding
SYNGTI_1468	COG3385	transposase activity
SYNGTI_1470	COG3385	transposase activity
SYNGTI_1472	COG0517	IMP dehydrogenase activity
SYNGTI_1472	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SYNGTI_1475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SYNGTI_1477	COG1215	transferase activity, transferring glycosyl groups
SYNGTI_1481	COG1216	Glycosyl transferase, family 2
SYNGTI_1482	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SYNGTI_1485	COG1028	Short-chain dehydrogenase reductase Sdr
SYNGTI_1490	COG0463	Glycosyl transferase, family 2
SYNGTI_1491	COG0113	porphobilinogen synthase activity
SYNGTI_1493	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SYNGTI_1494	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SYNGTI_1498	COG0312	modulator of DNA gyrase
SYNGTI_1499	COG2890	protein-(glutamine-N5) methyltransferase activity
SYNGTI_1500	COG2205	protein histidine kinase activity
SYNGTI_1503	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SYNGTI_1504	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SYNGTI_1509	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_1511	COG2205	protein histidine kinase activity
SYNGTI_1511	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SYNGTI_1512	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SYNGTI_1513	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SYNGTI_1514	COG0612	Peptidase, M16
SYNGTI_1515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYNGTI_1516	COG3259	Nickel-dependent hydrogenase
SYNGTI_1519	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
SYNGTI_1520	COG1034	ATP synthesis coupled electron transport
SYNGTI_1527	COG0702	epimerase
SYNGTI_1534	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SYNGTI_1535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SYNGTI_1538	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SYNGTI_1540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SYNGTI_1541	COG0673	inositol 2-dehydrogenase activity
SYNGTI_1544	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SYNGTI_1545	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SYNGTI_1553	COG0095	Lipoate-protein ligase
SYNGTI_1556	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SYNGTI_1558	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SYNGTI_1561	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SYNGTI_1562	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SYNGTI_1563	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYNGTI_1564	COG0457	Tetratricopeptide repeat
SYNGTI_1565	COG1160	GTP binding
SYNGTI_1569	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SYNGTI_1571	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SYNGTI_1572	COG0052	Belongs to the universal ribosomal protein uS2 family
SYNGTI_1573	COG0387	Pfam Sodium calcium exchanger
SYNGTI_1574	COG0717	Belongs to the dCTP deaminase family
SYNGTI_1580	COG3385	transposase activity
SYNGTI_1581	COG1253	flavin adenine dinucleotide binding
SYNGTI_1583	COG3046	protein related to deoxyribodipyrimidine photolyase
SYNGTI_1584	COG0516	GMP reductase activity
SYNGTI_1584	COG0517	IMP dehydrogenase activity
SYNGTI_1586	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SYNGTI_1590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SYNGTI_1590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SYNGTI_1591	COG0288	reversible hydration of carbon dioxide
SYNGTI_1592	COG1045	serine acetyltransferase
SYNGTI_1593	COG0166	Belongs to the GPI family
SYNGTI_1594	COG3239	Fatty acid desaturase
SYNGTI_1595	COG1672	PFAM Archaeal ATPase
SYNGTI_1596	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SYNGTI_1597	COG2010	Cytochrome c
SYNGTI_1598	COG0359	binds to the 23S rRNA
SYNGTI_1600	COG1032	radical SAM domain protein
SYNGTI_1605	COG0298	carbon dioxide binding
SYNGTI_1606	COG0109	protoheme IX farnesyltransferase activity
SYNGTI_1607	COG1612	heme a metabolic process
SYNGTI_1611	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SYNGTI_1612	COG5001	Diguanylate cyclase
SYNGTI_1612	COG1716	ATPase activity
SYNGTI_1613	COG3631	Ketosteroid isomerase-related protein
SYNGTI_1615	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYNGTI_1615	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYNGTI_1617	COG0107	imidazoleglycerol-phosphate synthase activity
SYNGTI_1622	COG2205	protein histidine kinase activity
SYNGTI_1622	COG2202	Pas domain
SYNGTI_1625	COG4783	chaperone-mediated protein folding
SYNGTI_1626	COG2205	protein histidine kinase activity
SYNGTI_1626	COG3437	response regulator, receiver
SYNGTI_1626	COG3850	Histidine kinase
SYNGTI_1626	COG4999	Histidine kinase
SYNGTI_1628	COG4956	integral membrane protein (PIN domain superfamily)
SYNGTI_1631	COG1160	GTP binding
SYNGTI_1633	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SYNGTI_1636	COG0432	Pfam Uncharacterised protein family UPF0047
SYNGTI_1637	COG2197	response regulator
SYNGTI_1638	COG3842	ATPase activity
SYNGTI_1640	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SYNGTI_1641	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SYNGTI_1643	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYNGTI_1644	COG5398	heme oxygenase
SYNGTI_1645	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SYNGTI_1647	COG1316	TRANSCRIPTIONal
SYNGTI_1649	COG0745	RESPONSE REGULATOR receiver
SYNGTI_1649	COG3706	GGDEF domain
SYNGTI_1650	COG2770	Histidine kinase
SYNGTI_1650	COG2208	phosphoserine phosphatase activity
SYNGTI_1651	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SYNGTI_1653	COG0539	negative regulation of cytoplasmic translation
SYNGTI_1654	COG0358	DNA primase activity
SYNGTI_1656	COG0009	L-threonylcarbamoyladenylate synthase
SYNGTI_1660	COG0589	response to stress
SYNGTI_1664	COG2082	Precorrin-8x methylmutase
SYNGTI_1666	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SYNGTI_1667	COG0594	ribonuclease P activity
SYNGTI_1669	COG0706	membrane insertase activity
SYNGTI_1671	COG0484	heat shock protein binding
SYNGTI_1672	COG0483	inositol monophosphate 1-phosphatase activity
SYNGTI_1673	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SYNGTI_1674	COG0791	NLP P60 protein
SYNGTI_1677	COG0540	Belongs to the ATCase OTCase family
SYNGTI_1679	COG1215	transferase activity, transferring glycosyl groups
SYNGTI_1681	COG3000	fatty acid hydroxylase
SYNGTI_1681	COG0300	oxidoreductase activity
SYNGTI_1682	COG2211	Major facilitator Superfamily
SYNGTI_1685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNGTI_1688	COG0723	plastoquinol--plastocyanin reductase activity
SYNGTI_1689	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYNGTI_1690	COG2274	protein secretion by the type I secretion system
SYNGTI_1691	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYNGTI_1692	COG2192	nodulation
SYNGTI_1694	COG0772	Belongs to the SEDS family
SYNGTI_1695	COG0405	Gamma-glutamyltransferase
SYNGTI_1698	COG3659	wide pore channel activity
SYNGTI_1706	COG0037	tRNA processing
SYNGTI_1707	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SYNGTI_1708	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_1709	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_1710	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_1718	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYNGTI_1720	COG0628	permease
SYNGTI_1723	COG0066	3-isopropylmalate dehydratase activity
SYNGTI_1724	COG0504	CTP synthase activity
SYNGTI_1726	COG2204	response regulator
SYNGTI_1728	COG0259	pyridoxamine-phosphate oxidase activity
SYNGTI_1731	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SYNGTI_1734	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYNGTI_1735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SYNGTI_1736	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SYNGTI_1736	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SYNGTI_1737	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SYNGTI_1739	COG1619	proteins homologs of microcin C7 resistance protein MccF
SYNGTI_1740	COG1357	PFAM Pentapeptide repeats (8 copies)
SYNGTI_1743	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SYNGTI_1745	COG0051	transcription antitermination factor activity, RNA binding
SYNGTI_1746	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SYNGTI_1747	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYNGTI_1748	COG0049	tRNA binding
SYNGTI_1749	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SYNGTI_1751	COG0151	Belongs to the GarS family
SYNGTI_1753	COG0698	ribose 5-phosphate isomerase
SYNGTI_1759	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SYNGTI_1760	COG2046	Belongs to the sulfate adenylyltransferase family
SYNGTI_1761	COG0297	glycogen (starch) synthase activity
SYNGTI_1764	COG0644	oxidoreductase
SYNGTI_1765	COG0371	Dehydrogenase
SYNGTI_1768	COG2119	membrane
SYNGTI_1769	COG0386	Belongs to the glutathione peroxidase family
SYNGTI_1771	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SYNGTI_1776	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SYNGTI_1777	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SYNGTI_1779	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SYNGTI_1780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYNGTI_1782	COG0375	protein maturation
SYNGTI_1785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SYNGTI_1786	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SYNGTI_1787	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SYNGTI_1788	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYNGTI_1789	COG1134	teichoic acid transport
SYNGTI_1794	COG1012	belongs to the aldehyde dehydrogenase family
SYNGTI_1797	COG3385	transposase activity
SYNGTI_1804	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYNGTI_1806	COG1304	FMN binding
SYNGTI_1807	COG0745	RESPONSE REGULATOR receiver
SYNGTI_1809	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SYNGTI_1811	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SYNGTI_1811	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYNGTI_1812	COG4251	negative regulation of phosphorylation
SYNGTI_1812	COG2203	Gaf domain
SYNGTI_1812	COG5001	Diguanylate cyclase
SYNGTI_1812	COG3706	GGDEF domain
SYNGTI_1813	COG0784	Response regulator, receiver
SYNGTI_1815	COG0072	phenylalanine-tRNA ligase activity
SYNGTI_1815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYNGTI_1816	COG1357	PFAM Pentapeptide repeats (8 copies)
SYNGTI_1816	COG0515	serine threonine protein kinase
SYNGTI_1817	COG2197	response regulator
SYNGTI_1818	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SYNGTI_1821	COG0157	Belongs to the NadC ModD family
SYNGTI_1824	COG2082	Precorrin-8x methylmutase
SYNGTI_1825	COG0612	Peptidase, M16
SYNGTI_1826	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SYNGTI_1828	COG0656	L-ascorbic acid biosynthetic process
SYNGTI_1829	COG3588	fructose-bisphosphate aldolase
SYNGTI_1831	COG0798	PFAM Bile acid sodium symporter
SYNGTI_1832	COG0431	NADPH-dependent FMN reductase
SYNGTI_1833	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SYNGTI_1837	COG0488	(ABC) transporter
SYNGTI_1839	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SYNGTI_1843	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SYNGTI_1844	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SYNGTI_1845	COG0561	phosphatase activity
SYNGTI_1847	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SYNGTI_1848	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYNGTI_1850	COG0215	cysteine-tRNA ligase activity
SYNGTI_1851	COG0424	maF-like protein
SYNGTI_1854	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SYNGTI_1855	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SYNGTI_1856	COG0463	Glycosyl transferase, family 2
SYNGTI_1857	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SYNGTI_1860	COG1472	Belongs to the glycosyl hydrolase 3 family
SYNGTI_1861	COG2816	NAD+ diphosphatase activity
SYNGTI_1862	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SYNGTI_1863	COG1280	lysine exporter protein (LysE YggA)
SYNGTI_1866	COG0564	pseudouridine synthase activity
SYNGTI_1868	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_1875	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SYNGTI_1878	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_1880	COG0500	methyltransferase
SYNGTI_1881	COG0542	response to heat
SYNGTI_1883	COG0572	uridine kinase
SYNGTI_1884	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SYNGTI_1885	COG0561	phosphatase activity
SYNGTI_1888	COG0571	ribonuclease III activity
SYNGTI_1889	COG0390	transport system, permease component
SYNGTI_1890	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SYNGTI_1891	COG2161	toxin-antitoxin pair type II binding
SYNGTI_1893	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SYNGTI_1894	COG0426	domain, Protein
SYNGTI_1894	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYNGTI_1895	COG0497	DNA recombination
SYNGTI_1897	COG3751	2OG-Fe(II) oxygenase superfamily
SYNGTI_1901	COG2161	toxin-antitoxin pair type II binding
SYNGTI_1905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SYNGTI_1906	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYNGTI_1908	COG1446	asparaginase
SYNGTI_1909	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SYNGTI_1911	COG0832	Belongs to the urease beta subunit family
SYNGTI_1913	COG2226	methyltransferase
SYNGTI_1916	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SYNGTI_1918	COG0025	NhaP-type Na H and K H
SYNGTI_1920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYNGTI_1922	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SYNGTI_1930	COG3239	Fatty acid desaturase
SYNGTI_1932	COG1950	PFAM Membrane protein of
SYNGTI_1935	COG1253	flavin adenine dinucleotide binding
SYNGTI_1936	COG0228	four-way junction DNA binding
SYNGTI_1940	COG2010	Cytochrome c
SYNGTI_1943	COG0802	atpase or kinase
SYNGTI_1944	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SYNGTI_1944	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SYNGTI_1949	COG0126	phosphoglycerate kinase activity
SYNGTI_1950	COG0583	DNA-binding transcription factor activity
SYNGTI_1951	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SYNGTI_1958	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYNGTI_1960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SYNGTI_1961	COG0347	Belongs to the P(II) protein family
SYNGTI_1964	COG0135	phosphoribosylanthranilate isomerase activity
SYNGTI_1965	COG0697	spore germination
SYNGTI_1967	COG0418	dihydroorotase activity
SYNGTI_1968	COG2226	methyltransferase
SYNGTI_1971	COG1672	PFAM Archaeal ATPase
SYNGTI_1971	COG2319	Wd-40 repeat
SYNGTI_1980	COG2815	serine threonine protein kinase
SYNGTI_1980	COG0515	serine threonine protein kinase
SYNGTI_1985	COG0233	cytoplasmic translational termination
SYNGTI_1986	COG0528	UMP kinase activity
SYNGTI_1987	COG1598	PFAM Uncharacterised protein family UPF0150
SYNGTI_1988	COG0542	response to heat
SYNGTI_1994	COG0740	serine-type endopeptidase activity
SYNGTI_1995	COG0740	serine-type endopeptidase activity
SYNGTI_1996	COG0006	proline dipeptidase activity
SYNGTI_1997	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SYNGTI_2002	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
SYNGTI_2004	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SYNGTI_2005	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SYNGTI_2011	COG2165	general secretion pathway protein
SYNGTI_2013	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SYNGTI_2020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SYNGTI_2024	COG0105	UTP biosynthetic process
SYNGTI_2029	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SYNGTI_2030	COG2937	Belongs to the GPAT DAPAT family
SYNGTI_2031	COG0501	Belongs to the peptidase M48B family
SYNGTI_2035	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SYNGTI_2037	COG0463	Glycosyl transferase, family 2
SYNGTI_2039	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SYNGTI_2042	COG0508	dehydrogenase complex catalyzes the overall conversion of
SYNGTI_2044	COG2217	Heavy metal translocating P-type atpase
SYNGTI_2046	COG0217	transcriptional regulatory protein
SYNGTI_2047	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SYNGTI_2048	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SYNGTI_2049	COG0739	heme binding
SYNGTI_2050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SYNGTI_2051	COG0321	lipoyl(octanoyl) transferase activity
SYNGTI_2053	COG0297	glycogen (starch) synthase activity
SYNGTI_2056	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNGTI_2057	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SYNGTI_2058	COG2198	Histidine kinase
SYNGTI_2058	COG0643	Histidine kinase
SYNGTI_2065	COG1178	ABC-type Fe3 transport system permease component
SYNGTI_2066	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SYNGTI_2071	COG2197	response regulator
SYNGTI_2073	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_2078	COG0237	dephospho-CoA kinase activity
SYNGTI_2078	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNGTI_2086	COG0517	IMP dehydrogenase activity
SYNGTI_2086	COG0516	GMP reductase activity
SYNGTI_2088	COG1937	Protein conserved in bacteria
SYNGTI_2090	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SYNGTI_2094	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SYNGTI_2095	COG0443	Heat shock 70 kDa protein
SYNGTI_2096	COG0484	heat shock protein binding
SYNGTI_2099	COG1587	Uroporphyrinogen-III synthase
SYNGTI_2100	COG2319	Wd-40 repeat
SYNGTI_2103	COG3385	transposase activity
SYNGTI_2106	COG1381	Involved in DNA repair and RecF pathway recombination
SYNGTI_2109	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SYNGTI_2113	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SYNGTI_2114	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SYNGTI_2115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYNGTI_2116	COG5001	Diguanylate cyclase
SYNGTI_2118	COG1187	pseudouridine synthase activity
SYNGTI_2119	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SYNGTI_2125	COG1012	belongs to the aldehyde dehydrogenase family
SYNGTI_2126	COG5002	protein histidine kinase activity
SYNGTI_2127	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SYNGTI_2128	COG2308	Evidence 4 Homologs of previously reported genes of
SYNGTI_2134	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SYNGTI_2136	COG0346	lactoylglutathione lyase activity
SYNGTI_2137	COG1028	Short-chain dehydrogenase reductase Sdr
SYNGTI_2138	COG0742	ribosomal rna small subunit methyltransferase
SYNGTI_2139	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_2140	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SYNGTI_2144	COG1104	cysteine desulfurase activity
SYNGTI_2145	COG1040	competence protein
SYNGTI_2146	COG1376	ErfK ybiS ycfS ynhG family protein
SYNGTI_2149	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SYNGTI_2151	COG3659	wide pore channel activity
SYNGTI_2152	COG0477	Major facilitator Superfamily
SYNGTI_2153	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYNGTI_2154	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYNGTI_2155	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYNGTI_2156	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SYNGTI_2157	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SYNGTI_2158	COG2003	Belongs to the UPF0758 family
SYNGTI_2165	COG1131	(ABC) transporter
SYNGTI_2167	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SYNGTI_2169	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SYNGTI_2171	COG0450	alkyl hydroperoxide reductase
SYNGTI_2172	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SYNGTI_2174	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SYNGTI_2176	COG1231	oxidoreductase activity
SYNGTI_2177	COG2205	protein histidine kinase activity
SYNGTI_2179	COG0149	triose-phosphate isomerase activity
SYNGTI_2180	COG0628	permease
SYNGTI_2183	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SYNGTI_2184	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SYNGTI_2187	COG0571	ribonuclease III activity
SYNGTI_2188	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SYNGTI_2193	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SYNGTI_2197	COG3385	transposase activity
SYNGTI_2199	COG3385	transposase activity
SYNGTI_2202	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SYNGTI_2203	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SYNGTI_2206	COG0601	transmembrane transport
SYNGTI_2207	COG0124	histidyl-tRNA synthetase
SYNGTI_2216	COG0542	response to heat
SYNGTI_2217	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SYNGTI_2218	COG0191	fructose-bisphosphate aldolase activity
SYNGTI_2219	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SYNGTI_2223	COG0793	Belongs to the peptidase S41A family
SYNGTI_2224	COG1850	ribulose-bisphosphate carboxylase activity
SYNGTI_2226	COG4451	ribulose bisphosphate carboxylase, small
SYNGTI_2228	COG1285	pathogenesis
SYNGTI_2230	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYNGTI_2231	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SYNGTI_2233	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SYNGTI_2234	COG0114	fumarate hydratase activity
SYNGTI_2239	COG0436	Aminotransferase
SYNGTI_2240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNGTI_2241	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SYNGTI_2242	COG0616	signal peptide processing
SYNGTI_2243	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SYNGTI_2244	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SYNGTI_2244	COG0519	Catalyzes the synthesis of GMP from XMP
SYNGTI_2246	COG1968	undecaprenyl-diphosphatase activity
SYNGTI_2250	COG5322	oxidoreductase activity
SYNGTI_2251	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SYNGTI_2253	COG0751	glycine-tRNA ligase activity
SYNGTI_2256	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SYNGTI_2257	COG5002	protein histidine kinase activity
SYNGTI_2258	COG0445	tRNA wobble uridine modification
SYNGTI_2262	COG3794	PFAM blue (type 1) copper domain protein
SYNGTI_2265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNGTI_2266	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SYNGTI_2267	COG0805	protein transport
SYNGTI_2268	COG2084	Dehydrogenase
SYNGTI_2270	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SYNGTI_2272	COG0586	Pfam SNARE associated Golgi protein
SYNGTI_2273	COG3118	belongs to the thioredoxin family
SYNGTI_2274	COG3751	2OG-Fe(II) oxygenase superfamily
SYNGTI_2275	COG0459	protein refolding
SYNGTI_2276	COG1131	(ABC) transporter
SYNGTI_2282	COG4399	Belongs to the UPF0754 family
SYNGTI_2283	COG0824	Thioesterase
SYNGTI_2284	COG4948	Mandelate Racemase Muconate Lactonizing
SYNGTI_2285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYNGTI_2286	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SYNGTI_2287	COG0511	ligase activity, forming carbon-carbon bonds
SYNGTI_2291	COG0277	FAD linked oxidase domain protein
SYNGTI_2296	COG0436	Aminotransferase
SYNGTI_2297	COG0372	Belongs to the citrate synthase family
SYNGTI_2298	COG2062	phosphohistidine phosphatase, SixA
SYNGTI_2299	COG0596	Alpha beta hydrolase
SYNGTI_2302	COG1234	tRNA 3'-trailer cleavage
SYNGTI_2305	COG0788	formyltetrahydrofolate deformylase activity
SYNGTI_2309	COG0625	glutathione transferase activity
SYNGTI_2311	COG0440	acetolactate synthase activity
SYNGTI_2313	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SYNGTI_2314	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SYNGTI_2316	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SYNGTI_2317	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SYNGTI_2319	COG0628	permease
SYNGTI_2325	COG0628	permease
SYNGTI_2326	COG0443	Heat shock 70 kDa protein
SYNGTI_2327	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SYNGTI_2328	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SYNGTI_2329	COG0116	Belongs to the methyltransferase superfamily
SYNGTI_2331	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYNGTI_2331	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYNGTI_2332	COG0612	Peptidase, M16
SYNGTI_2333	COG0489	protein tyrosine kinase activity
SYNGTI_2334	COG0439	Biotin carboxylase
SYNGTI_2335	COG3224	Antibiotic biosynthesis monooxygenase
SYNGTI_2336	COG0590	tRNA wobble adenosine to inosine editing
SYNGTI_2337	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SYNGTI_2340	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SYNGTI_2342	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SYNGTI_2343	COG4251	negative regulation of phosphorylation
SYNGTI_2344	COG0784	Response regulator, receiver
SYNGTI_2345	COG0556	nucleotide-excision repair
SYNGTI_2350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNGTI_2351	COG2890	protein-(glutamine-N5) methyltransferase activity
SYNGTI_2352	COG0525	valine-tRNA ligase activity
SYNGTI_2353	COG5002	protein histidine kinase activity
SYNGTI_2355	COG0728	peptidoglycan biosynthetic process
SYNGTI_2358	COG0318	PFAM AMP-dependent synthetase and ligase
SYNGTI_2361	COG0460	homoserine dehydrogenase
SYNGTI_2362	COG2091	lysine biosynthetic process via aminoadipic acid
SYNGTI_2364	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SYNGTI_2368	COG0475	glutathione-regulated potassium exporter activity
SYNGTI_2371	COG4232	protein-disulfide reductase activity
SYNGTI_2373	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYNGTI_2374	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYNGTI_2375	COG0581	inorganic phosphate transmembrane transporter activity
SYNGTI_2378	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYNGTI_2380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SYNGTI_2381	COG1842	Phage shock protein A
SYNGTI_2383	COG0653	protein targeting
SYNGTI_2384	COG2119	membrane
SYNGTI_2386	COG2255	four-way junction helicase activity
SYNGTI_2387	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYNGTI_2387	COG2022	thiamine diphosphate biosynthetic process
SYNGTI_2389	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SYNGTI_2391	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SYNGTI_2393	COG0752	glycyl-tRNA synthetase alpha subunit
SYNGTI_2394	COG0668	transmembrane transport
SYNGTI_2395	COG5002	protein histidine kinase activity
SYNGTI_2398	COG2211	Major facilitator Superfamily
SYNGTI_2401	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SYNGTI_2402	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SYNGTI_2406	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYNGTI_2407	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYNGTI_2409	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SYNGTI_2411	COG0745	RESPONSE REGULATOR receiver
SYNGTI_2412	COG0406	alpha-ribazole phosphatase activity
SYNGTI_2414	COG0475	glutathione-regulated potassium exporter activity
SYNGTI_2414	COG0589	response to stress
SYNGTI_2416	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SYNGTI_2418	COG1122	ATPase activity
SYNGTI_2420	COG0310	cobalt ion transport
SYNGTI_2426	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_2427	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYNGTI_2430	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYNGTI_2431	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SYNGTI_2433	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SYNGTI_2435	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SYNGTI_2437	COG1598	PFAM Uncharacterised protein family UPF0150
SYNGTI_2439	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SYNGTI_2441	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SYNGTI_2442	COG0302	gtp cyclohydrolase
SYNGTI_2443	COG1058	Belongs to the CinA family
SYNGTI_2443	COG1546	Belongs to the CinA family
SYNGTI_2444	COG0792	nuclease activity
SYNGTI_2446	COG2247	cell wall binding repeat
SYNGTI_2446	COG2385	sporulation resulting in formation of a cellular spore
SYNGTI_2447	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SYNGTI_2449	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SYNGTI_2454	COG0121	glutamine amidotransferase
SYNGTI_2455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNGTI_2456	COG2048	Heterodisulfide reductase, subunit B
SYNGTI_2457	COG0762	integral membrane protein
SYNGTI_2460	COG4178	(ABC) transporter
SYNGTI_2464	COG0824	Thioesterase
SYNGTI_2465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SYNGTI_2470	COG2205	protein histidine kinase activity
SYNGTI_2470	COG2202	Pas domain
SYNGTI_2473	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SYNGTI_2474	COG1410	methionine synthase
SYNGTI_2474	COG0646	methionine synthase
SYNGTI_2478	COG0646	methionine synthase
SYNGTI_2478	COG1410	methionine synthase
SYNGTI_2481	COG1309	transcriptional regulator
SYNGTI_2482	COG0534	Mate efflux family protein
SYNGTI_2485	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SYNGTI_2486	COG0303	'Molybdopterin
SYNGTI_2487	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SYNGTI_2488	COG0315	cyclic pyranopterin monophosphate synthase activity
SYNGTI_2488	COG0746	molybdenum cofactor guanylyltransferase activity
SYNGTI_2490	COG0314	molybdopterin synthase activity
SYNGTI_2492	COG0606	chelatase, subunit chli
SYNGTI_2493	COG1032	radical SAM domain protein
SYNGTI_2501	COG0156	8-amino-7-oxononanoate synthase activity
SYNGTI_2502	COG0024	Methionine aminopeptidase
SYNGTI_2504	COG0494	nUDIX hydrolase
SYNGTI_2505	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SYNGTI_2506	COG0039	L-malate dehydrogenase activity
SYNGTI_2509	COG0193	aminoacyl-tRNA hydrolase activity
SYNGTI_2513	COG3263	regulation of cellular component size
SYNGTI_2514	COG0024	Methionine aminopeptidase
SYNGTI_2515	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
SYNGTI_2518	COG4243	Vitamin k epoxide reductase
SYNGTI_2519	COG0426	domain, Protein
SYNGTI_2519	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYNGTI_2520	COG0613	PHP domain protein
SYNGTI_2521	COG2251	uridine kinase activity
SYNGTI_2522	COG3063	Type IV pilus biogenesis stability protein PilW
SYNGTI_2523	COG0023	Translation Initiation Factor
SYNGTI_2533	COG2124	cytochrome p450
SYNGTI_2535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SYNGTI_2538	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SYNGTI_2541	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYNGTI_2543	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SYNGTI_2545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SYNGTI_2546	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SYNGTI_2547	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SYNGTI_2548	COG4251	negative regulation of phosphorylation
SYNGTI_2548	COG5001	Diguanylate cyclase
SYNGTI_2548	COG2203	Gaf domain
SYNGTI_2548	COG3706	GGDEF domain
SYNGTI_2549	COG0659	secondary active sulfate transmembrane transporter activity
SYNGTI_2550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SYNGTI_2553	COG1372	Participates in initiation and elongation during chromosome replication
SYNGTI_2553	COG0305	Participates in initiation and elongation during chromosome replication
SYNGTI_2554	COG0714	Associated with various cellular activities
SYNGTI_2557	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYNGTI_2558	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SYNGTI_2559	COG2226	methyltransferase
SYNGTI_2560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYNGTI_2561	COG0154	amidase activity
SYNGTI_2564	COG2203	Gaf domain
SYNGTI_2564	COG5001	Diguanylate cyclase
SYNGTI_2564	COG4251	negative regulation of phosphorylation
SYNGTI_2564	COG3706	GGDEF domain
SYNGTI_2567	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYNGTI_2570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SYNGTI_2572	COG1959	2 iron, 2 sulfur cluster binding
SYNGTI_2573	COG5001	Diguanylate cyclase
SYNGTI_2573	COG2203	Gaf domain
SYNGTI_2573	COG3706	GGDEF domain
SYNGTI_2573	COG4251	negative regulation of phosphorylation
SYNGTI_2574	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SYNGTI_2576	COG0357	Ribosomal RNA small subunit methyltransferase G
SYNGTI_2579	COG0719	Fe-S assembly protein
SYNGTI_2580	COG0396	ATPase activity
SYNGTI_2581	COG0719	Fe-S assembly protein
SYNGTI_2582	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SYNGTI_2583	COG0003	Pfam Anion-transporting ATPase
SYNGTI_2586	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SYNGTI_2587	COG0720	synthase
SYNGTI_2590	COG0328	RNA-DNA hybrid ribonuclease activity
SYNGTI_2591	COG0745	RESPONSE REGULATOR receiver
SYNGTI_2592	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYNGTI_2593	COG0513	Belongs to the DEAD box helicase family
SYNGTI_2594	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SYNGTI_2595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SYNGTI_2596	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SYNGTI_2597	COG0443	Heat shock 70 kDa protein
SYNGTI_2599	COG2226	methyltransferase
SYNGTI_2600	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SYNGTI_2601	COG1012	belongs to the aldehyde dehydrogenase family
SYNGTI_2602	COG1216	Glycosyl transferase, family 2
SYNGTI_2603	COG0484	heat shock protein binding
SYNGTI_2605	COG0659	secondary active sulfate transmembrane transporter activity
SYNGTI_2607	COG1131	(ABC) transporter
SYNGTI_2608	COG0131	Imidazoleglycerol-phosphate dehydratase
SYNGTI_2610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNGTI_2611	COG4251	negative regulation of phosphorylation
SYNGTI_2612	COG2197	response regulator
SYNGTI_2615	COG0515	serine threonine protein kinase
SYNGTI_2617	COG1028	Short-chain dehydrogenase reductase Sdr
SYNGTI_2620	COG0436	Aminotransferase
SYNGTI_2621	COG0586	Pfam SNARE associated Golgi protein
SYNGTI_2622	COG3264	Mechanosensitive ion channel
SYNGTI_2622	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SYNGTI_2625	COG0848	biopolymer transport protein
SYNGTI_2626	COG0848	biopolymer transport protein
SYNGTI_2627	COG0811	peptide transport
SYNGTI_2628	COG1840	ABC-type Fe3 transport system, periplasmic component
SYNGTI_2630	COG1357	PFAM Pentapeptide repeats (8 copies)
SYNGTI_2631	COG2205	protein histidine kinase activity
SYNGTI_2633	COG0456	acetyltransferase
SYNGTI_2635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYNGTI_2636	COG0047	phosphoribosylformylglycinamidine synthase activity
SYNGTI_2641	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SYNGTI_2642	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SYNGTI_2643	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SYNGTI_2644	COG0628	permease
SYNGTI_2647	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNGTI_2648	COG0837	glucose binding
SYNGTI_2649	COG1132	(ABC) transporter
SYNGTI_2653	COG0668	transmembrane transport
SYNGTI_2654	COG1492	cobalamin metabolic process
SYNGTI_2658	COG0469	pyruvate kinase activity
SYNGTI_2659	COG2081	HI0933 family
SYNGTI_2660	COG3118	belongs to the thioredoxin family
SYNGTI_2663	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SYNGTI_2666	COG0463	Glycosyl transferase, family 2
SYNGTI_2666	COG0457	Tetratricopeptide repeat
SYNGTI_2668	COG0004	ammonium transporteR
SYNGTI_2669	COG0800	Aldolase
SYNGTI_2671	COG1480	7TM receptor with intracellular HD hydrolase
SYNGTI_2672	COG2304	oxidoreductase activity
SYNGTI_2674	COG1192	Involved in chromosome partitioning
SYNGTI_2677	COG1473	amidohydrolase
SYNGTI_2679	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SYNGTI_2683	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SYNGTI_2684	COG2205	protein histidine kinase activity
SYNGTI_2684	COG0784	Response regulator, receiver
SYNGTI_2685	COG1192	Involved in chromosome partitioning
SYNGTI_2689	COG0745	RESPONSE REGULATOR receiver
SYNGTI_2693	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SYNGTI_2695	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SYNGTI_2697	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SYNGTI_2698	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SYNGTI_2699	COG2894	cell division
SYNGTI_2700	COG0850	regulation of cytokinetic process
SYNGTI_2701	COG1716	ATPase activity
SYNGTI_2704	COG0574	Belongs to the PEP-utilizing enzyme family
SYNGTI_2704	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SYNGTI_2705	COG3706	GGDEF domain
SYNGTI_2705	COG0745	RESPONSE REGULATOR receiver
SYNGTI_2708	COG0398	Pfam SNARE associated Golgi protein
SYNGTI_2709	COG0737	Belongs to the 5'-nucleotidase family
SYNGTI_2710	COG0454	-acetyltransferase
SYNGTI_2713	COG1032	radical SAM domain protein
SYNGTI_2717	COG4585	Histidine kinase
SYNGTI_2718	COG2197	response regulator
SYNGTI_2719	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SYNGTI_2719	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SYNGTI_2720	COG2267	carboxylic ester hydrolase activity
SYNGTI_2721	COG4221	oxidoreductase activity
SYNGTI_2727	COG0024	Methionine aminopeptidase
SYNGTI_2729	COG1056	cytidyltransferase-related domain
SYNGTI_2729	COG1051	belongs to the nudix hydrolase family
SYNGTI_2732	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SYNGTI_2733	COG5002	protein histidine kinase activity
SYNGTI_2738	COG2814	Major facilitator Superfamily
SYNGTI_2740	COG2217	Heavy metal translocating P-type atpase
SYNGTI_2741	COG1742	UPF0060 membrane protein
SYNGTI_2742	COG0640	Transcriptional regulator
SYNGTI_2743	COG2217	Heavy metal translocating P-type atpase
SYNGTI_2744	COG5002	protein histidine kinase activity
SYNGTI_2745	COG0745	RESPONSE REGULATOR receiver
SYNGTI_2750	COG2144	transferase activity, transferring acyl groups
SYNGTI_2755	COG2072	flavoprotein involved in K transport
SYNGTI_2756	COG2197	response regulator
SYNGTI_2759	COG3706	GGDEF domain
SYNGTI_2759	COG5001	Diguanylate cyclase
SYNGTI_2759	COG4251	negative regulation of phosphorylation
SYNGTI_2759	COG2203	Gaf domain
SYNGTI_2760	COG0842	Transport permease protein
SYNGTI_2760	COG1131	(ABC) transporter
SYNGTI_2760	COG1716	ATPase activity
SYNGTI_2762	COG0515	serine threonine protein kinase
SYNGTI_2762	COG4991	sh3 domain protein
SYNGTI_2762	COG3064	Membrane
SYNGTI_2764	COG0401	homolog of Blt101
SYNGTI_2769	COG0789	Transcriptional regulator
SYNGTI_2780	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYNGTI_2781	COG0598	Magnesium transport protein CorA
SYNGTI_2784	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYNGTI_2784	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYNGTI_2791	COG0251	oxidation-reduction process
SYNGTI_2792	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SYNGTI_2793	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SYNGTI_2794	COG0392	lysyltransferase activity
SYNGTI_2798	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SYNGTI_2800	COG0343	queuine tRNA-ribosyltransferase activity
SYNGTI_2803	COG2886	Uncharacterised protein family (UPF0175)
SYNGTI_2804	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYNGTI_2805	COG0668	transmembrane transport
SYNGTI_2806	COG0205	6-phosphofructokinase activity
SYNGTI_2810	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYNGTI_2810	COG1013	pyruvate-flavodoxin oxidoreductase activity
SYNGTI_2810	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SYNGTI_2810	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SYNGTI_2812	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SYNGTI_2813	COG0725	ABC transporter, periplasmic molybdate-binding protein
SYNGTI_2818	COG0438	transferase activity, transferring glycosyl groups
SYNGTI_2822	COG0840	transmembrane signaling receptor activity
SYNGTI_2823	COG2203	Gaf domain
SYNGTI_2823	COG0840	transmembrane signaling receptor activity
SYNGTI_2826	COG0784	Response regulator, receiver
SYNGTI_2828	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SYNGTI_2829	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYNGTI_2830	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
SYNGTI_2831	COG1597	lipid kinase activity
SYNGTI_2831	COG1803	Methylglyoxal synthase
SYNGTI_2837	COG0857	belongs to the CobB CobQ family
SYNGTI_2838	COG0583	DNA-binding transcription factor activity
SYNGTI_2839	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYNGTI_2840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYNGTI_2841	COG3659	wide pore channel activity
SYNGTI_2842	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYNGTI_2842	COG1116	anion transmembrane transporter activity
SYNGTI_2843	COG1116	anion transmembrane transporter activity
SYNGTI_2845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYNGTI_2847	COG0724	RNA recognition motif
SYNGTI_2848	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNGTI_2849	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SYNGTI_2850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SYNGTI_2851	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SYNGTI_2852	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SYNGTI_2853	COG1653	transport
SYNGTI_2854	COG1175	transmembrane transport
SYNGTI_2855	COG0395	ABC-type sugar transport system, permease component
SYNGTI_2857	COG2205	protein histidine kinase activity
SYNGTI_2858	COG0741	lytic transglycosylase activity
SYNGTI_2860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SYNGTI_2863	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SYNGTI_2864	COG0598	Magnesium transport protein CorA
SYNGTI_2865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SYNGTI_2866	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SYNGTI_2867	COG0019	diaminopimelate decarboxylase activity
SYNGTI_2868	COG1160	GTP binding
SYNGTI_2869	COG0018	arginyl-trna synthetase
SYNGTI_2870	COG0463	Glycosyl transferase, family 2
SYNGTI_2872	COG0740	serine-type endopeptidase activity
SYNGTI_2873	COG0133	tryptophan synthase activity
SYNGTI_2875	COG1136	(ABC) transporter
SYNGTI_2876	COG2314	TM2 domain
SYNGTI_2880	COG0017	Asparaginyl-tRNA synthetase
SYNGTI_2882	COG0569	domain protein
SYNGTI_2883	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SYNGTI_2884	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SYNGTI_2885	COG0629	single-stranded DNA binding
SYNGTI_2886	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SYNGTI_2888	COG1192	Involved in chromosome partitioning
SYNGTI_2890	COG2119	membrane
SYNGTI_2891	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SYNGTI_2892	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SYNGTI_2894	COG1162	GTPase activity
SYNGTI_2896	COG0484	heat shock protein binding
SYNGTI_2897	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SYNGTI_2898	COG1218	3'(2'),5'-bisphosphate nucleotidase
SYNGTI_2899	COG0134	indole-3-glycerol-phosphate synthase activity
SYNGTI_2900	COG0004	ammonium transporteR
SYNGTI_2901	COG0569	domain protein
SYNGTI_2902	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SYNGTI_2903	COG0740	serine-type endopeptidase activity
SYNGTI_2904	COG0544	peptidyl-prolyl cis-trans isomerase activity
SYNGTI_2905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SYNGTI_2906	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SYNGTI_2907	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SYNGTI_2909	COG0237	dephospho-CoA kinase activity
SYNGTI_2912	COG0517	IMP dehydrogenase activity
SYNGTI_2912	COG1994	Peptidase M50
SYNGTI_2913	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SYNGTI_2917	COG0525	valine-tRNA ligase activity
SYNGTI_2918	COG0713	ATP synthesis coupled electron transport
SYNGTI_2919	COG0839	Belongs to the complex I subunit 6 family
SYNGTI_2920	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYNGTI_2921	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SYNGTI_2922	COG0167	dihydroorotate dehydrogenase activity
SYNGTI_2923	COG2166	iron-sulfur cluster assembly
SYNGTI_2924	COG1070	Carbohydrate kinase
SYNGTI_2927	COG0308	aminopeptidase N
SYNGTI_2928	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SYNGTI_2929	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SYNGTI_2930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SYNGTI_2932	COG2193	ferroxidase activity
SYNGTI_2934	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SYNGTI_2936	COG1834	amidinotransferase
SYNGTI_2937	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYNGTI_2942	COG0745	RESPONSE REGULATOR receiver
SYNGTI_2943	COG0483	inositol monophosphate 1-phosphatase activity
SYNGTI_2946	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SYNGTI_2947	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SYNGTI_2948	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SYNGTI_2949	COG4208	sulfate ABC transporter
SYNGTI_2950	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SYNGTI_2951	COG2165	general secretion pathway protein
SYNGTI_2954	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYNGTI_2957	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYNGTI_2958	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYNGTI_2959	COG0731	radical SAM domain protein
SYNGTI_2960	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SYNGTI_2961	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SYNGTI_2963	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SYNGTI_2964	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SYNGTI_2967	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNGTI_2973	COG0339	signal peptide processing
SYNGTI_2974	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SYNGTI_2978	COG1166	arginine decarboxylase activity
SYNGTI_2980	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SYNGTI_2984	COG1049	propionate catabolic process, 2-methylcitrate cycle
SYNGTI_2988	COG0070	glutamate synthase
SYNGTI_2988	COG0069	glutamate synthase activity
SYNGTI_2988	COG0067	glutamate synthase
SYNGTI_2989	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SYNGTI_2990	COG0505	Belongs to the CarA family
SYNGTI_2992	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYNGTI_2993	COG0579	oxidoreductase
SYNGTI_2994	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SYNGTI_2995	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SYNGTI_2996	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SYNGTI_2998	COG1191	sigma factor activity
SYNGTI_2999	COG0316	Belongs to the HesB IscA family
SYNGTI_3000	COG0463	Glycosyl transferase, family 2
SYNGTI_3001	COG2319	Wd-40 repeat
SYNGTI_3004	COG1691	(AIR) carboxylase
SYNGTI_3005	COG0739	heme binding
SYNGTI_3010	COG2052	Domain of unknown function (DUF370)
SYNGTI_3011	COG3264	Mechanosensitive ion channel
SYNGTI_3011	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SYNGTI_3018	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SYNGTI_3021	COG0363	glucosamine-6-phosphate deaminase activity
SYNGTI_3025	COG5001	Diguanylate cyclase
SYNGTI_3025	COG4251	negative regulation of phosphorylation
SYNGTI_3025	COG3706	GGDEF domain
SYNGTI_3025	COG2203	Gaf domain
SYNGTI_3027	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNGTI_3031	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SYNGTI_3032	COG3300	MHYT domain
SYNGTI_3032	COG5001	Diguanylate cyclase
SYNGTI_3034	COG3842	ATPase activity
SYNGTI_3036	COG1543	Belongs to the glycosyl hydrolase 57 family
SYNGTI_3038	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SYNGTI_3039	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SYNGTI_3041	COG0457	Tetratricopeptide repeat
SYNGTI_3042	COG0148	phosphopyruvate hydratase activity
SYNGTI_3044	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SYNGTI_3047	COG0825	malonyl-CoA metabolic process
SYNGTI_3050	COG1598	PFAM Uncharacterised protein family UPF0150
SYNGTI_3054	COG4251	negative regulation of phosphorylation
SYNGTI_3055	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SYNGTI_3059	COG2994	toxin metabolic process
SYNGTI_3062	COG0170	dolichyl monophosphate biosynthetic process
SYNGTI_3063	COG1473	amidohydrolase
SYNGTI_3064	COG3659	wide pore channel activity
SYNGTI_3068	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SYNGTI_3069	COG5001	Diguanylate cyclase
SYNGTI_3069	COG4251	negative regulation of phosphorylation
SYNGTI_3069	COG3706	GGDEF domain
SYNGTI_3069	COG2203	Gaf domain
SYNGTI_3073	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SYNGTI_3078	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SYNGTI_3081	COG2197	response regulator
SYNGTI_3087	COG2153	protein acetylation
SYNGTI_3097	COG4581	dead DEAH box helicase
SYNGTI_3099	COG0322	excinuclease ABC activity
SYNGTI_3100	COG0129	dihydroxy-acid dehydratase activity
SYNGTI_3101	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SYNGTI_3107	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SYNGTI_3108	COG0546	phosphoglycolate phosphatase activity
SYNGTI_3114	COG0326	Molecular chaperone. Has ATPase activity
SYNGTI_3115	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SYNGTI_3118	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SYNGTI_3119	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SYNGTI_3121	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SYNGTI_3126	COG0723	plastoquinol--plastocyanin reductase activity
SYNGTI_3129	COG1842	Phage shock protein A
SYNGTI_3133	COG1064	alcohol dehydrogenase
SYNGTI_3134	COG0137	argininosuccinate synthase activity
SYNGTI_3137	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SYNGTI_3142	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SYNGTI_3145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SYNGTI_3146	COG0549	Belongs to the carbamate kinase family
SYNGTI_3149	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYNGTI_3150	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SYNGTI_3151	COG1136	(ABC) transporter
SYNGTI_3151	COG0577	efflux transmembrane transporter activity
SYNGTI_3152	COG0735	belongs to the Fur family
SYNGTI_3154	COG0138	bifunctional purine biosynthesis protein purh
SYNGTI_3158	COG0515	serine threonine protein kinase
SYNGTI_3163	COG0587	DNA-directed DNA polymerase activity
SYNGTI_3164	COG0481	GTPase activity
SYNGTI_3165	COG0435	Glutathione S-transferase
SYNGTI_3168	COG0140	phosphoribosyl-ATP diphosphatase activity
SYNGTI_3168	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SYNGTI_3169	COG0523	cobalamin synthesis protein