locus-tag	class	description
HTZ78_00030	COG1982	Orn Lys Arg decarboxylase major
HTZ78_00040	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HTZ78_00060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HTZ78_00065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HTZ78_00070	COG0745	RESPONSE REGULATOR receiver
HTZ78_00075	COG0673	inositol 2-dehydrogenase activity
HTZ78_00080	COG0700	Nucleoside recognition
HTZ78_00085	COG2715	membrane protein required for spore maturation
HTZ78_00090	COG1640	4-alpha-glucanotransferase
HTZ78_00100	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HTZ78_00105	COG2203	Gaf domain
HTZ78_00105	COG3706	GGDEF domain
HTZ78_00105	COG4251	negative regulation of phosphorylation
HTZ78_00105	COG5001	Diguanylate cyclase
HTZ78_00110	COG2205	protein histidine kinase activity
HTZ78_00110	COG0784	Response regulator, receiver
HTZ78_00125	COG1981	membrane
HTZ78_00130	COG0175	sulfate reduction
HTZ78_00135	COG1420	regulation of RNA biosynthetic process
HTZ78_00145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HTZ78_00150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HTZ78_00160	COG0003	Pfam Anion-transporting ATPase
HTZ78_00165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HTZ78_00180	COG0484	heat shock protein binding
HTZ78_00185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTZ78_00205	COG0077	Prephenate dehydratase
HTZ78_00205	COG1605	Chorismate mutase
HTZ78_00215	COG2203	Gaf domain
HTZ78_00215	COG4251	negative regulation of phosphorylation
HTZ78_00215	COG5001	Diguanylate cyclase
HTZ78_00215	COG3706	GGDEF domain
HTZ78_00235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HTZ78_00240	COG1595	DNA-templated transcription, initiation
HTZ78_00255	COG0415	Belongs to the DNA photolyase family
HTZ78_00280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HTZ78_00290	COG1252	NADH dehydrogenase
HTZ78_00330	COG0678	peroxiredoxin activity
HTZ78_00360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HTZ78_00365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HTZ78_00380	COG2205	protein histidine kinase activity
HTZ78_00385	COG2890	protein-(glutamine-N5) methyltransferase activity
HTZ78_00390	COG0312	modulator of DNA gyrase
HTZ78_00410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HTZ78_00420	COG0113	porphobilinogen synthase activity
HTZ78_00460	COG0463	Glycosyl transferase, family 2
HTZ78_00475	COG1442	glycosyl transferase family 8
HTZ78_00490	COG0500	methyltransferase
HTZ78_00530	COG4115	mRNA cleavage
HTZ78_00535	COG2161	toxin-antitoxin pair type II binding
HTZ78_00560	COG0629	single-stranded DNA binding
HTZ78_00565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HTZ78_00570	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HTZ78_00580	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HTZ78_00605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HTZ78_00645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HTZ78_00655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HTZ78_00665	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HTZ78_00685	COG0095	Lipoate-protein ligase
HTZ78_00690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HTZ78_00695	COG0656	L-ascorbic acid biosynthetic process
HTZ78_00705	COG1575	Belongs to the MenA family. Type 1 subfamily
HTZ78_00715	COG0473	3-isopropylmalate dehydrogenase activity
HTZ78_00720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HTZ78_00725	COG3063	Type IV pilus biogenesis stability protein PilW
HTZ78_00745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HTZ78_00750	COG0347	Belongs to the P(II) protein family
HTZ78_00765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HTZ78_00770	COG0416	fatty acid biosynthetic process
HTZ78_00780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HTZ78_00785	COG0438	transferase activity, transferring glycosyl groups
HTZ78_00815	COG0454	-acetyltransferase
HTZ78_00830	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HTZ78_00845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HTZ78_00850	COG1247	-acetyltransferase
HTZ78_00855	COG0174	glutamine synthetase
HTZ78_00865	COG5001	Diguanylate cyclase
HTZ78_00865	COG4251	negative regulation of phosphorylation
HTZ78_00865	COG3706	GGDEF domain
HTZ78_00865	COG2203	Gaf domain
HTZ78_00875	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HTZ78_00895	COG2310	stress, protein
HTZ78_00905	COG0076	glutamate decarboxylase activity
HTZ78_00920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HTZ78_00925	COG0829	nickel cation binding
HTZ78_00945	COG1045	serine acetyltransferase
HTZ78_00965	COG0412	Dienelactone hydrolase
HTZ78_00970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HTZ78_00975	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HTZ78_00980	COG1294	oxidase, subunit
HTZ78_00985	COG1271	oxidase subunit
HTZ78_00995	COG0681	Belongs to the peptidase S26 family
HTZ78_01005	COG2226	methyltransferase
HTZ78_01020	COG3937	granule-associated protein
HTZ78_01025	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HTZ78_01025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HTZ78_01030	COG0745	RESPONSE REGULATOR receiver
HTZ78_01040	COG0668	transmembrane transport
HTZ78_01050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HTZ78_01065	COG0438	transferase activity, transferring glycosyl groups
HTZ78_01075	COG2205	protein histidine kinase activity
HTZ78_01075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HTZ78_01080	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HTZ78_01085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HTZ78_01095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HTZ78_01100	COG3259	Nickel-dependent hydrogenase
HTZ78_01115	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
HTZ78_01120	COG1034	ATP synthesis coupled electron transport
HTZ78_01145	COG0409	Hydrogenase expression formation protein
HTZ78_01155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HTZ78_01160	COG0297	glycogen (starch) synthase activity
HTZ78_01175	COG1131	(ABC) transporter
HTZ78_01190	COG0668	transmembrane transport
HTZ78_01220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HTZ78_01225	COG1121	(ABC) transporter
HTZ78_01230	COG0803	Belongs to the bacterial solute-binding protein 9 family
HTZ78_01265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HTZ78_01280	COG0163	prenyltransferase activity
HTZ78_01290	COG0589	response to stress
HTZ78_01295	COG1716	ATPase activity
HTZ78_01295	COG5001	Diguanylate cyclase
HTZ78_01300	COG1716	ATPase activity
HTZ78_01300	COG5001	Diguanylate cyclase
HTZ78_01310	COG1217	gtp-binding protein TYPA
HTZ78_01330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HTZ78_01340	COG0442	prolyl-tRNA aminoacylation
HTZ78_01350	COG4372	Transposase
HTZ78_01355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HTZ78_01370	COG3588	fructose-bisphosphate aldolase
HTZ78_01375	COG0656	L-ascorbic acid biosynthetic process
HTZ78_01380	COG0784	Response regulator, receiver
HTZ78_01380	COG4191	Histidine kinase
HTZ78_01395	COG1357	PFAM Pentapeptide repeats (8 copies)
HTZ78_01405	COG2816	NAD+ diphosphatase activity
HTZ78_01410	COG0165	Argininosuccinate lyase
HTZ78_01420	COG2208	phosphoserine phosphatase activity
HTZ78_01435	COG0438	transferase activity, transferring glycosyl groups
HTZ78_01440	COG0557	exoribonuclease II activity
HTZ78_01470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HTZ78_01480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HTZ78_01485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HTZ78_01495	COG0745	RESPONSE REGULATOR receiver
HTZ78_01500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HTZ78_01505	COG2217	Heavy metal translocating P-type atpase
HTZ78_01515	COG3063	Type IV pilus biogenesis stability protein PilW
HTZ78_01520	COG1132	(ABC) transporter
HTZ78_01580	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTZ78_01585	COG1006	Multisubunit Na H antiporter MnhC subunit
HTZ78_01620	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HTZ78_01635	COG0587	DNA-directed DNA polymerase activity
HTZ78_01640	COG0739	heme binding
HTZ78_01650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HTZ78_01655	COG2988	succinylglutamate desuccinylase activity
HTZ78_01665	COG0515	serine threonine protein kinase
HTZ78_01695	COG0237	dephospho-CoA kinase activity
HTZ78_01700	COG0237	dephospho-CoA kinase activity
HTZ78_01705	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HTZ78_01710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HTZ78_01725	COG1596	polysaccharide export
HTZ78_01735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HTZ78_01740	COG3411	Ferredoxin
HTZ78_01750	COG2385	sporulation resulting in formation of a cellular spore
HTZ78_01760	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HTZ78_01790	COG1309	transcriptional regulator
HTZ78_01800	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HTZ78_01805	COG5002	protein histidine kinase activity
HTZ78_01835	COG1132	(ABC) transporter
HTZ78_01840	COG0837	glucose binding
HTZ78_01845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HTZ78_01860	COG0628	permease
HTZ78_01865	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HTZ78_01870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HTZ78_01875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HTZ78_01900	COG0024	Methionine aminopeptidase
HTZ78_01905	COG4221	oxidoreductase activity
HTZ78_01930	COG0625	glutathione transferase activity
HTZ78_01955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HTZ78_01960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HTZ78_01970	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HTZ78_01975	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HTZ78_02025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HTZ78_02025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HTZ78_02035	COG0612	Peptidase, M16
HTZ78_02040	COG0489	protein tyrosine kinase activity
HTZ78_02045	COG0505	Belongs to the CarA family
HTZ78_02055	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HTZ78_02080	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HTZ78_02085	COG0006	proline dipeptidase activity
HTZ78_02090	COG0740	serine-type endopeptidase activity
HTZ78_02095	COG0740	serine-type endopeptidase activity
HTZ78_02100	COG1459	type II secretion system
HTZ78_02130	COG0542	response to heat
HTZ78_02140	COG0528	UMP kinase activity
HTZ78_02145	COG0233	cytoplasmic translational termination
HTZ78_02160	COG3268	Saccharopine dehydrogenase
HTZ78_02215	COG1410	methionine synthase
HTZ78_02215	COG0646	methionine synthase
HTZ78_02220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HTZ78_02235	COG2205	protein histidine kinase activity
HTZ78_02235	COG2202	Pas domain
HTZ78_02260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HTZ78_02270	COG0824	Thioesterase
HTZ78_02280	COG4178	(ABC) transporter
HTZ78_02295	COG0762	integral membrane protein
HTZ78_02300	COG2048	Heterodisulfide reductase, subunit B
HTZ78_02310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HTZ78_02315	COG0121	glutamine amidotransferase
HTZ78_02325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HTZ78_02340	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HTZ78_02350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HTZ78_02355	COG2247	cell wall binding repeat
HTZ78_02355	COG2385	sporulation resulting in formation of a cellular spore
HTZ78_02365	COG0792	nuclease activity
HTZ78_02370	COG1546	Belongs to the CinA family
HTZ78_02370	COG1058	Belongs to the CinA family
HTZ78_02375	COG0302	gtp cyclohydrolase
HTZ78_02380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HTZ78_02390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HTZ78_02405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HTZ78_02440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HTZ78_02460	COG0105	UTP biosynthetic process
HTZ78_02480	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HTZ78_02490	COG0501	Belongs to the peptidase M48B family
HTZ78_02520	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HTZ78_02530	COG0463	Glycosyl transferase, family 2
HTZ78_02540	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HTZ78_02555	COG0508	dehydrogenase complex catalyzes the overall conversion of
HTZ78_02560	COG3093	addiction module antidote protein HigA
HTZ78_02565	COG3549	Plasmid maintenance system killer
HTZ78_02570	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HTZ78_02575	COG0515	serine threonine protein kinase
HTZ78_02575	COG1357	PFAM Pentapeptide repeats (8 copies)
HTZ78_02585	COG2217	Heavy metal translocating P-type atpase
HTZ78_02595	COG0217	transcriptional regulatory protein
HTZ78_02600	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HTZ78_02605	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HTZ78_02610	COG0739	heme binding
HTZ78_02615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HTZ78_02620	COG0321	lipoyl(octanoyl) transferase activity
HTZ78_02635	COG0297	glycogen (starch) synthase activity
HTZ78_02650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HTZ78_02655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HTZ78_02660	COG0643	Histidine kinase
HTZ78_02660	COG2198	Histidine kinase
HTZ78_02660	COG0784	Response regulator, receiver
HTZ78_02660	COG0643	Histidine kinase
HTZ78_02660	COG0784	Response regulator, receiver
HTZ78_02660	COG2198	Histidine kinase
HTZ78_02680	COG1357	PFAM Pentapeptide repeats (8 copies)
HTZ78_02685	COG2816	NAD+ diphosphatase activity
HTZ78_02690	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HTZ78_02695	COG0039	L-malate dehydrogenase activity
HTZ78_02710	COG0193	aminoacyl-tRNA hydrolase activity
HTZ78_02740	COG0024	Methionine aminopeptidase
HTZ78_02745	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
HTZ78_02760	COG4243	Vitamin k epoxide reductase
HTZ78_02765	COG0426	domain, Protein
HTZ78_02765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HTZ78_02775	COG2251	uridine kinase activity
HTZ78_02780	COG3063	Type IV pilus biogenesis stability protein PilW
HTZ78_02785	COG0023	Translation Initiation Factor
HTZ78_02825	COG2954	triphosphatase activity
HTZ78_02835	COG0401	homolog of Blt101
HTZ78_02840	COG2211	Major facilitator Superfamily
HTZ78_02865	COG4451	ribulose bisphosphate carboxylase, small
HTZ78_02875	COG1850	ribulose-bisphosphate carboxylase activity
HTZ78_02880	COG0793	Belongs to the peptidase S41A family
HTZ78_02895	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HTZ78_02900	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HTZ78_02905	COG0191	fructose-bisphosphate aldolase activity
HTZ78_02910	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HTZ78_02920	COG0542	response to heat
HTZ78_02960	COG0124	histidyl-tRNA synthetase
HTZ78_02970	COG1357	PFAM Pentapeptide repeats (8 copies)
HTZ78_02970	COG0515	serine threonine protein kinase
HTZ78_02975	COG0601	transmembrane transport
HTZ78_02985	COG1748	Saccharopine dehydrogenase
HTZ78_03010	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HTZ78_03015	COG1122	ATPase activity
HTZ78_03030	COG1012	belongs to the aldehyde dehydrogenase family
HTZ78_03035	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HTZ78_03035	COG3264	Mechanosensitive ion channel
HTZ78_03040	COG0586	Pfam SNARE associated Golgi protein
HTZ78_03045	COG0436	Aminotransferase
HTZ78_03060	COG1028	Short-chain dehydrogenase reductase Sdr
HTZ78_03070	COG0515	serine threonine protein kinase
HTZ78_03080	COG1136	(ABC) transporter
HTZ78_03080	COG0577	efflux transmembrane transporter activity
HTZ78_03085	COG2197	response regulator
HTZ78_03090	COG4251	negative regulation of phosphorylation
HTZ78_03095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HTZ78_03105	COG0131	Imidazoleglycerol-phosphate dehydratase
HTZ78_03110	COG1131	(ABC) transporter
HTZ78_03120	COG0659	secondary active sulfate transmembrane transporter activity
HTZ78_03130	COG0484	heat shock protein binding
HTZ78_03135	COG1216	Glycosyl transferase, family 2
HTZ78_03140	COG1012	belongs to the aldehyde dehydrogenase family
HTZ78_03145	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HTZ78_03150	COG2226	methyltransferase
HTZ78_03160	COG0443	Heat shock 70 kDa protein
HTZ78_03165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HTZ78_03170	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HTZ78_03175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HTZ78_03180	COG0513	Belongs to the DEAD box helicase family
HTZ78_03185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HTZ78_03190	COG0745	RESPONSE REGULATOR receiver
HTZ78_03195	COG0328	RNA-DNA hybrid ribonuclease activity
HTZ78_03210	COG0720	synthase
HTZ78_03215	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HTZ78_03220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HTZ78_03230	COG0003	Pfam Anion-transporting ATPase
HTZ78_03235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HTZ78_03240	COG0719	Fe-S assembly protein
HTZ78_03245	COG0396	ATPase activity
HTZ78_03250	COG0719	Fe-S assembly protein
HTZ78_03260	COG2198	Histidine kinase
HTZ78_03260	COG0643	Histidine kinase
HTZ78_03265	COG0357	Ribosomal RNA small subunit methyltransferase G
HTZ78_03275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HTZ78_03280	COG5001	Diguanylate cyclase
HTZ78_03280	COG2203	Gaf domain
HTZ78_03280	COG3706	GGDEF domain
HTZ78_03280	COG4251	negative regulation of phosphorylation
HTZ78_03285	COG1959	2 iron, 2 sulfur cluster binding
HTZ78_03295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HTZ78_03310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HTZ78_03320	COG0617	tRNA 3'-terminal CCA addition
HTZ78_03370	COG0732	type I restriction modification DNA specificity domain
HTZ78_03390	COG2203	Gaf domain
HTZ78_03390	COG5001	Diguanylate cyclase
HTZ78_03390	COG4251	negative regulation of phosphorylation
HTZ78_03390	COG3706	GGDEF domain
HTZ78_03405	COG0154	amidase activity
HTZ78_03410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HTZ78_03415	COG2226	methyltransferase
HTZ78_03420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HTZ78_03425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HTZ78_03430	COG0326	Molecular chaperone. Has ATPase activity
HTZ78_03435	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HTZ78_03450	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HTZ78_03455	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HTZ78_03465	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HTZ78_03495	COG0723	plastoquinol--plastocyanin reductase activity
HTZ78_03505	COG5002	protein histidine kinase activity
HTZ78_03510	COG3300	MHYT domain
HTZ78_03510	COG5001	Diguanylate cyclase
HTZ78_03520	COG1842	Phage shock protein A
HTZ78_03540	COG1064	alcohol dehydrogenase
HTZ78_03555	COG0137	argininosuccinate synthase activity
HTZ78_03570	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HTZ78_03575	COG1357	PFAM Pentapeptide repeats (8 copies)
HTZ78_03595	COG3621	Patatin-like phospholipase
HTZ78_03610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HTZ78_03635	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HTZ78_03640	COG0549	Belongs to the carbamate kinase family
HTZ78_03655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HTZ78_03660	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HTZ78_03665	COG0577	efflux transmembrane transporter activity
HTZ78_03665	COG1136	(ABC) transporter
HTZ78_03670	COG0735	belongs to the Fur family
HTZ78_03680	COG0138	bifunctional purine biosynthesis protein purh
HTZ78_03700	COG0515	serine threonine protein kinase
HTZ78_03720	COG0587	DNA-directed DNA polymerase activity
HTZ78_03725	COG0481	GTPase activity
HTZ78_03730	COG4251	negative regulation of phosphorylation
HTZ78_03735	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HTZ78_03750	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HTZ78_03755	COG0612	Peptidase, M16
HTZ78_03760	COG2082	Precorrin-8x methylmutase
HTZ78_03775	COG0157	Belongs to the NadC ModD family
HTZ78_03800	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HTZ78_03805	COG2197	response regulator
HTZ78_03825	COG0072	phenylalanine-tRNA ligase activity
HTZ78_03825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HTZ78_03835	COG0784	Response regulator, receiver
HTZ78_03840	COG2203	Gaf domain
HTZ78_03840	COG5001	Diguanylate cyclase
HTZ78_03840	COG4251	negative regulation of phosphorylation
HTZ78_03840	COG3706	GGDEF domain
HTZ78_03845	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HTZ78_03845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HTZ78_03855	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HTZ78_03870	COG0745	RESPONSE REGULATOR receiver
HTZ78_03880	COG1304	FMN binding
HTZ78_03890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HTZ78_03930	COG1381	Involved in DNA repair and RecF pathway recombination
HTZ78_03945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HTZ78_03950	COG0581	inorganic phosphate transmembrane transporter activity
HTZ78_03955	COG0573	inorganic phosphate transmembrane transporter activity
HTZ78_03960	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HTZ78_03975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HTZ78_03990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HTZ78_03995	COG0672	)-iron permease
HTZ78_04000	COG0592	DNA-directed DNA polymerase activity
HTZ78_04005	COG0159	tryptophan synthase activity
HTZ78_04020	COG0436	Aminotransferase
HTZ78_04035	COG0523	cobalamin synthesis protein
HTZ78_04045	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HTZ78_04065	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HTZ78_04075	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HTZ78_04080	COG0701	Predicted permease
HTZ78_04100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HTZ78_04105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HTZ78_04110	COG4636	protein conserved in cyanobacteria
HTZ78_04115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HTZ78_04135	COG3206	protein involved in exopolysaccharide biosynthesis
HTZ78_04135	COG0489	protein tyrosine kinase activity
HTZ78_04175	COG1598	PFAM Uncharacterised protein family UPF0150
HTZ78_04235	COG1598	PFAM Uncharacterised protein family UPF0150
HTZ78_04295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HTZ78_04300	COG1028	Short-chain dehydrogenase reductase Sdr
HTZ78_04310	COG1215	transferase activity, transferring glycosyl groups
HTZ78_04325	COG1215	transferase activity, transferring glycosyl groups
HTZ78_04345	COG0438	transferase activity, transferring glycosyl groups
HTZ78_04370	COG2264	protein methyltransferase activity
HTZ78_04405	COG0438	transferase activity, transferring glycosyl groups
HTZ78_04420	COG0438	transferase activity, transferring glycosyl groups
HTZ78_04435	COG0110	maltose O-acetyltransferase activity
HTZ78_04450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HTZ78_04460	COG3781	membrane
HTZ78_04465	COG0045	succinate-CoA ligase (ADP-forming) activity
HTZ78_04470	COG0861	Integral membrane protein TerC family
HTZ78_04495	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HTZ78_04505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTZ78_04510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HTZ78_04515	COG0004	ammonium transporteR
HTZ78_04520	COG2205	protein histidine kinase activity
HTZ78_04530	COG0737	Belongs to the 5'-nucleotidase family
HTZ78_04535	COG0529	Catalyzes the synthesis of activated sulfate
HTZ78_04540	COG0811	peptide transport
HTZ78_04545	COG0848	biopolymer transport protein
HTZ78_04550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HTZ78_04550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HTZ78_04565	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HTZ78_04570	COG0745	RESPONSE REGULATOR receiver
HTZ78_04575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HTZ78_04595	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HTZ78_04605	COG0469	pyruvate kinase activity
HTZ78_04610	COG2081	HI0933 family
HTZ78_04615	COG3118	belongs to the thioredoxin family
HTZ78_04630	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HTZ78_04645	COG0457	Tetratricopeptide repeat
HTZ78_04645	COG0463	Glycosyl transferase, family 2
HTZ78_04670	COG0501	Belongs to the peptidase M48B family
HTZ78_04675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HTZ78_04685	COG0011	TIGRFAM Protein of
HTZ78_04690	COG0589	response to stress
HTZ78_04700	COG0123	including yeast histone deacetylase and acetoin utilization protein
HTZ78_04705	COG0010	Belongs to the arginase family
HTZ78_04710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HTZ78_04750	COG2099	Precorrin-6x reductase
HTZ78_04760	COG1007	ATP synthesis coupled electron transport
HTZ78_04765	COG4245	von Willebrand factor, type A
HTZ78_04795	COG1598	PFAM Uncharacterised protein family UPF0150
HTZ78_04825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HTZ78_04830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HTZ78_04840	COG0426	domain, Protein
HTZ78_04840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HTZ78_04850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HTZ78_04850	COG0426	domain, Protein
HTZ78_04860	COG0793	Belongs to the peptidase S41A family
HTZ78_04865	COG0009	L-threonylcarbamoyladenylate synthase
HTZ78_04870	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HTZ78_04890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HTZ78_04895	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HTZ78_04900	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HTZ78_04905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HTZ78_04910	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HTZ78_04915	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HTZ78_04920	COG0356	it plays a direct role in the translocation of protons across the membrane
HTZ78_04935	COG2205	protein histidine kinase activity
HTZ78_04945	COG0714	Associated with various cellular activities
HTZ78_04950	COG0316	Belongs to the HesB IscA family
HTZ78_04955	COG0697	spore germination
HTZ78_04965	COG1127	ABC transporter
HTZ78_04975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HTZ78_04990	COG1203	CRISPR-associated helicase, Cas3
HTZ78_05000	COG1857	crispr-associated protein
HTZ78_05025	COG1468	defense response to virus
HTZ78_05025	COG1518	maintenance of DNA repeat elements
HTZ78_05030	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HTZ78_05045	COG0556	nucleotide-excision repair
HTZ78_05060	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HTZ78_05080	COG0525	valine-tRNA ligase activity
HTZ78_05085	COG5002	protein histidine kinase activity
HTZ78_05095	COG0728	peptidoglycan biosynthetic process
HTZ78_05110	COG0318	PFAM AMP-dependent synthetase and ligase
HTZ78_05125	COG0460	homoserine dehydrogenase
HTZ78_05130	COG2091	lysine biosynthetic process via aminoadipic acid
HTZ78_05140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HTZ78_05160	COG0475	glutathione-regulated potassium exporter activity
HTZ78_05175	COG4232	protein-disulfide reductase activity
HTZ78_05180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTZ78_05185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HTZ78_05190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HTZ78_05195	COG0581	inorganic phosphate transmembrane transporter activity
HTZ78_05210	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HTZ78_05225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HTZ78_05235	COG1842	Phage shock protein A
HTZ78_05250	COG0653	protein targeting
HTZ78_05260	COG2255	four-way junction helicase activity
HTZ78_05265	COG2022	thiamine diphosphate biosynthetic process
HTZ78_05265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HTZ78_05270	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
HTZ78_05280	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HTZ78_05345	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HTZ78_05350	COG2894	cell division
HTZ78_05355	COG0850	regulation of cytokinetic process
HTZ78_05360	COG1716	ATPase activity
HTZ78_05370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HTZ78_05370	COG0574	Belongs to the PEP-utilizing enzyme family
HTZ78_05375	COG3706	GGDEF domain
HTZ78_05400	COG0398	Pfam SNARE associated Golgi protein
HTZ78_05405	COG2226	methyltransferase
HTZ78_05415	COG0398	Pfam SNARE associated Golgi protein
HTZ78_05430	COG0804	urea catabolic process
HTZ78_05455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HTZ78_05460	COG1773	rubredoxin
HTZ78_05465	COG4447	cellulose binding
HTZ78_05490	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HTZ78_05500	COG3447	MASE1 domain protein
HTZ78_05500	COG5001	Diguanylate cyclase
HTZ78_05500	COG5002	protein histidine kinase activity
HTZ78_05510	COG3956	TIGRFAM MazG family protein
HTZ78_05520	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HTZ78_05535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HTZ78_05545	COG0557	exoribonuclease II activity
HTZ78_05550	COG0784	Response regulator, receiver
HTZ78_05565	COG0840	transmembrane signaling receptor activity
HTZ78_05570	COG0784	Response regulator, receiver
HTZ78_05570	COG2198	Histidine kinase
HTZ78_05570	COG0643	Histidine kinase
HTZ78_05575	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HTZ78_05595	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HTZ78_05600	COG0429	hydrolase of the alpha beta-hydrolase fold
HTZ78_05605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HTZ78_05610	COG3536	Protein conserved in bacteria
HTZ78_05615	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HTZ78_05620	COG0716	FMN binding
HTZ78_05635	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HTZ78_05640	COG0012	GTP binding
HTZ78_05660	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HTZ78_05670	COG0195	Participates in both transcription termination and antitermination
HTZ78_05675	COG0779	Required for maturation of 30S ribosomal subunits
HTZ78_05680	COG0704	Plays a role in the regulation of phosphate uptake
HTZ78_05700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HTZ78_05710	COG5002	protein histidine kinase activity
HTZ78_05715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HTZ78_05725	COG0582	viral genome integration into host DNA
HTZ78_05760	COG1104	cysteine desulfurase activity
HTZ78_05790	COG0484	heat shock protein binding
HTZ78_05805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HTZ78_05810	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HTZ78_05830	COG0681	Belongs to the peptidase S26 family
HTZ78_05835	COG1185	polyribonucleotide nucleotidyltransferase activity
HTZ78_05840	COG0494	nUDIX hydrolase
HTZ78_05845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HTZ78_05850	COG1530	ribonuclease E activity
HTZ78_05860	COG0330	HflC and HflK could
HTZ78_05875	COG1413	lyase activity
HTZ78_05880	COG0730	response to heat
HTZ78_05890	COG0406	alpha-ribazole phosphatase activity
HTZ78_05895	COG0194	GDP metabolic process
HTZ78_05900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HTZ78_05905	COG0494	nUDIX hydrolase
HTZ78_05915	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HTZ78_05930	COG3118	belongs to the thioredoxin family
HTZ78_05935	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HTZ78_05940	COG0563	adenylate kinase activity
HTZ78_05945	COG1174	glycine betaine transport
HTZ78_05950	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HTZ78_05965	COG1615	UPF0182 protein
HTZ78_05985	COG1214	PFAM Peptidase M22, glycoprotease
HTZ78_06000	COG4106	trans-aconitate 2-methyltransferase activity
HTZ78_06020	COG0579	oxidoreductase
HTZ78_06030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HTZ78_06035	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HTZ78_06040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HTZ78_06045	COG3001	Fructosamine kinase
HTZ78_06050	COG1191	sigma factor activity
HTZ78_06055	COG0316	Belongs to the HesB IscA family
HTZ78_06065	COG2319	Wd-40 repeat
HTZ78_06080	COG1691	(AIR) carboxylase
HTZ78_06085	COG0739	heme binding
HTZ78_06105	COG1496	oxidoreductase activity
HTZ78_06110	COG2052	Domain of unknown function (DUF370)
HTZ78_06115	COG3264	Mechanosensitive ion channel
HTZ78_06115	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HTZ78_06150	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HTZ78_06165	COG0363	glucosamine-6-phosphate deaminase activity
HTZ78_06180	COG5002	protein histidine kinase activity
HTZ78_06190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HTZ78_06235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HTZ78_06240	COG1132	(ABC) transporter
HTZ78_06255	COG0811	peptide transport
HTZ78_06260	COG0848	biopolymer transport protein
HTZ78_06270	COG2226	methyltransferase
HTZ78_06300	COG2207	Transcriptional regulator
HTZ78_06310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HTZ78_06315	COG1120	ATPase activity
HTZ78_06320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTZ78_06325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTZ78_06335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HTZ78_06340	COG1166	arginine decarboxylase activity
HTZ78_06360	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HTZ78_06365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HTZ78_06370	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HTZ78_06375	COG0515	serine threonine protein kinase
HTZ78_06385	COG1187	pseudouridine synthase activity
HTZ78_06390	COG0142	geranyltranstransferase activity
HTZ78_06400	COG0523	cobalamin synthesis protein
HTZ78_06405	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HTZ78_06405	COG0140	phosphoribosyl-ATP diphosphatase activity
HTZ78_06425	COG0435	Glutathione S-transferase
HTZ78_06435	COG0515	serine threonine protein kinase
HTZ78_06455	COG2166	iron-sulfur cluster assembly
HTZ78_06460	COG1070	Carbohydrate kinase
HTZ78_06505	COG0418	dihydroorotase activity
HTZ78_06520	COG1672	PFAM Archaeal ATPase
HTZ78_06520	COG2319	Wd-40 repeat
HTZ78_06610	COG0649	NAD binding
HTZ78_06615	COG2385	sporulation resulting in formation of a cellular spore
HTZ78_06635	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HTZ78_06650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HTZ78_06665	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HTZ78_06690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HTZ78_06705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HTZ78_06710	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HTZ78_06720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HTZ78_06725	COG5001	Diguanylate cyclase
HTZ78_06725	COG4251	negative regulation of phosphorylation
HTZ78_06725	COG3706	GGDEF domain
HTZ78_06725	COG2203	Gaf domain
HTZ78_06730	COG0659	secondary active sulfate transmembrane transporter activity
HTZ78_06735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HTZ78_06750	COG0305	Participates in initiation and elongation during chromosome replication
HTZ78_06750	COG1372	Participates in initiation and elongation during chromosome replication
HTZ78_06755	COG0714	Associated with various cellular activities
HTZ78_06770	COG0702	epimerase
HTZ78_06795	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HTZ78_06800	COG5001	Diguanylate cyclase
HTZ78_06800	COG1716	ATPase activity
HTZ78_06810	COG3842	ATPase activity
HTZ78_06820	COG1543	Belongs to the glycosyl hydrolase 57 family
HTZ78_06830	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HTZ78_06840	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HTZ78_06850	COG0457	Tetratricopeptide repeat
HTZ78_06855	COG0148	phosphopyruvate hydratase activity
HTZ78_06870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HTZ78_06885	COG0825	malonyl-CoA metabolic process
HTZ78_06900	COG1598	PFAM Uncharacterised protein family UPF0150
HTZ78_06925	COG4251	negative regulation of phosphorylation
HTZ78_06930	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HTZ78_06965	COG0170	dolichyl monophosphate biosynthetic process
HTZ78_06970	COG1473	amidohydrolase
HTZ78_06975	COG3659	wide pore channel activity
HTZ78_06990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HTZ78_06995	COG4251	negative regulation of phosphorylation
HTZ78_06995	COG2203	Gaf domain
HTZ78_06995	COG3706	GGDEF domain
HTZ78_06995	COG5001	Diguanylate cyclase
HTZ78_07025	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HTZ78_07050	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HTZ78_07065	COG2197	response regulator
HTZ78_07100	COG2153	protein acetylation
HTZ78_07105	COG1494	fructose-1,6-bisphosphatase
HTZ78_07115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTZ78_07130	COG0277	FAD linked oxidase domain protein
HTZ78_07150	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HTZ78_07155	COG0511	ligase activity, forming carbon-carbon bonds
HTZ78_07160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HTZ78_07165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HTZ78_07170	COG4948	Mandelate Racemase Muconate Lactonizing
HTZ78_07175	COG0824	Thioesterase
HTZ78_07180	COG4399	Belongs to the UPF0754 family
HTZ78_07195	COG0515	serine threonine protein kinase
HTZ78_07195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HTZ78_07210	COG1131	(ABC) transporter
HTZ78_07215	COG0459	protein refolding
HTZ78_07220	COG3751	2OG-Fe(II) oxygenase superfamily
HTZ78_07225	COG3118	belongs to the thioredoxin family
HTZ78_07230	COG0586	Pfam SNARE associated Golgi protein
HTZ78_07240	COG0751	glycine-tRNA ligase activity
HTZ78_07250	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HTZ78_07255	COG5322	oxidoreductase activity
HTZ78_07275	COG1968	undecaprenyl-diphosphatase activity
HTZ78_07280	COG2815	serine threonine protein kinase
HTZ78_07280	COG0515	serine threonine protein kinase
HTZ78_07285	COG0631	protein serine/threonine phosphatase activity
HTZ78_07300	COG0515	serine threonine protein kinase
HTZ78_07300	COG1357	PFAM Pentapeptide repeats (8 copies)
HTZ78_07320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HTZ78_07320	COG0519	Catalyzes the synthesis of GMP from XMP
HTZ78_07330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HTZ78_07335	COG0616	signal peptide processing
HTZ78_07340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HTZ78_07355	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HTZ78_07360	COG0436	Aminotransferase
HTZ78_07385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HTZ78_07410	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HTZ78_07450	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HTZ78_07455	COG1733	regulation of RNA biosynthetic process
HTZ78_07460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HTZ78_07470	COG0668	transmembrane transport
HTZ78_07500	COG3706	GGDEF domain
HTZ78_07500	COG2203	Gaf domain
HTZ78_07500	COG5001	Diguanylate cyclase
HTZ78_07500	COG4251	negative regulation of phosphorylation
HTZ78_07505	COG0564	pseudouridine synthase activity
HTZ78_07530	COG0434	BtpA family
HTZ78_07535	COG0352	thiamine-phosphate diphosphorylase activity
HTZ78_07540	COG3854	ATPases associated with a variety of cellular activities
HTZ78_07570	COG3273	potassium ion transport
HTZ78_07570	COG0471	metal ion transport
HTZ78_07580	COG2203	Gaf domain
HTZ78_07580	COG3706	GGDEF domain
HTZ78_07580	COG4251	negative regulation of phosphorylation
HTZ78_07580	COG5001	Diguanylate cyclase
HTZ78_07585	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HTZ78_07595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HTZ78_07630	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HTZ78_07635	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HTZ78_07650	COG1054	Belongs to the UPF0176 family
HTZ78_07655	COG2003	Belongs to the UPF0758 family
HTZ78_07660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HTZ78_07665	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HTZ78_07670	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HTZ78_07675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HTZ78_07680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HTZ78_07690	COG4636	protein conserved in cyanobacteria
HTZ78_07695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HTZ78_07705	COG0515	serine threonine protein kinase
HTZ78_07705	COG2815	serine threonine protein kinase
HTZ78_07710	COG0477	Major facilitator Superfamily
HTZ78_07715	COG3659	wide pore channel activity
HTZ78_07725	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HTZ78_07745	COG1376	ErfK ybiS ycfS ynhG family protein
HTZ78_07750	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HTZ78_07755	COG1104	cysteine desulfurase activity
HTZ78_07765	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HTZ78_07775	COG0742	ribosomal rna small subunit methyltransferase
HTZ78_07780	COG1028	Short-chain dehydrogenase reductase Sdr
HTZ78_07785	COG0346	lactoylglutathione lyase activity
HTZ78_07795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HTZ78_07825	COG2308	Evidence 4 Homologs of previously reported genes of
HTZ78_07830	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HTZ78_07835	COG5002	protein histidine kinase activity
HTZ78_07870	COG1049	propionate catabolic process, 2-methylcitrate cycle
HTZ78_07880	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HTZ78_07890	COG1166	arginine decarboxylase activity
HTZ78_07905	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HTZ78_07910	COG0339	signal peptide processing
HTZ78_07965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HTZ78_07985	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HTZ78_07990	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HTZ78_08000	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HTZ78_08005	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HTZ78_08020	COG0731	radical SAM domain protein
HTZ78_08025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HTZ78_08035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HTZ78_08040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HTZ78_08045	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HTZ78_08050	COG0271	Belongs to the BolA IbaG family
HTZ78_08070	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HTZ78_08085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HTZ78_08110	COG0222	ribosome binding
HTZ78_08120	COG2066	Belongs to the glutaminase family
HTZ78_08135	COG0287	Prephenate dehydrogenase
HTZ78_08140	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HTZ78_08155	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HTZ78_08160	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HTZ78_08165	COG1333	cytochrome c biogenesis protein
HTZ78_08175	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HTZ78_08175	COG3264	Mechanosensitive ion channel
HTZ78_08195	COG0436	Aminotransferase
HTZ78_08200	COG0372	Belongs to the citrate synthase family
HTZ78_08205	COG2062	phosphohistidine phosphatase, SixA
HTZ78_08210	COG0596	Alpha beta hydrolase
HTZ78_08225	COG1234	tRNA 3'-trailer cleavage
HTZ78_08245	COG0788	formyltetrahydrofolate deformylase activity
HTZ78_08265	COG0625	glutathione transferase activity
HTZ78_08275	COG0440	acetolactate synthase activity
HTZ78_08285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HTZ78_08290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HTZ78_08300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HTZ78_08315	COG0628	permease
HTZ78_08350	COG0628	permease
HTZ78_08355	COG0443	Heat shock 70 kDa protein
HTZ78_08360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HTZ78_08365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HTZ78_08370	COG0116	Belongs to the methyltransferase superfamily
HTZ78_08380	COG0552	protein localization to endoplasmic reticulum
HTZ78_08390	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HTZ78_08410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HTZ78_08415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HTZ78_08430	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HTZ78_08440	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HTZ78_08445	COG0673	inositol 2-dehydrogenase activity
HTZ78_08460	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HTZ78_08475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HTZ78_08480	COG0114	fumarate hydratase activity
HTZ78_08505	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HTZ78_08520	COG1253	flavin adenine dinucleotide binding
HTZ78_08530	COG3046	protein related to deoxyribodipyrimidine photolyase
HTZ78_08535	COG0517	IMP dehydrogenase activity
HTZ78_08535	COG0617	tRNA 3'-terminal CCA addition
HTZ78_08535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HTZ78_08545	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HTZ78_08595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HTZ78_08615	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HTZ78_08620	COG4208	sulfate ABC transporter
HTZ78_08625	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HTZ78_08630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HTZ78_08635	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HTZ78_08650	COG0483	inositol monophosphate 1-phosphatase activity
HTZ78_08655	COG0745	RESPONSE REGULATOR receiver
HTZ78_08675	COG4279	zinc finger
HTZ78_08690	COG1834	amidinotransferase
HTZ78_08700	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HTZ78_08710	COG2193	ferroxidase activity
HTZ78_08720	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HTZ78_08725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HTZ78_08730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HTZ78_08790	COG0156	8-amino-7-oxononanoate synthase activity
HTZ78_08795	COG0024	Methionine aminopeptidase
HTZ78_08820	COG1178	ABC-type Fe3 transport system permease component
HTZ78_08825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HTZ78_08850	COG2197	response regulator
HTZ78_08855	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTZ78_08865	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTZ78_08880	COG0237	dephospho-CoA kinase activity
HTZ78_08880	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HTZ78_08915	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HTZ78_08940	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HTZ78_08950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HTZ78_08970	COG1446	asparaginase
HTZ78_08975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HTZ78_08980	COG0832	Belongs to the urease beta subunit family
HTZ78_08985	COG2226	methyltransferase
HTZ78_09000	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HTZ78_09010	COG0025	NhaP-type Na H and K H
HTZ78_09020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HTZ78_09045	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HTZ78_09065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HTZ78_09105	COG3239	Fatty acid desaturase
HTZ78_09115	COG1950	PFAM Membrane protein of
HTZ78_09130	COG1253	flavin adenine dinucleotide binding
HTZ78_09135	COG0228	four-way junction DNA binding
HTZ78_09150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HTZ78_09155	COG2010	Cytochrome c
HTZ78_09170	COG0802	atpase or kinase
HTZ78_09175	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HTZ78_09175	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HTZ78_09180	COG0497	DNA recombination
HTZ78_09205	COG0322	excinuclease ABC activity
HTZ78_09220	COG1429	ligase activity, forming nitrogen-metal bonds
HTZ78_09240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HTZ78_09245	COG0577	efflux transmembrane transporter activity
HTZ78_09245	COG1136	(ABC) transporter
HTZ78_09255	COG0133	tryptophan synthase activity
HTZ78_09260	COG0740	serine-type endopeptidase activity
HTZ78_09265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HTZ78_09265	COG0519	Catalyzes the synthesis of GMP from XMP
HTZ78_09270	COG0463	Glycosyl transferase, family 2
HTZ78_09275	COG0018	arginyl-trna synthetase
HTZ78_09280	COG1160	GTP binding
HTZ78_09285	COG0019	diaminopimelate decarboxylase activity
HTZ78_09290	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HTZ78_09295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HTZ78_09300	COG0598	Magnesium transport protein CorA
HTZ78_09325	COG0717	Belongs to the dCTP deaminase family
HTZ78_09330	COG0387	Pfam Sodium calcium exchanger
HTZ78_09340	COG0052	Belongs to the universal ribosomal protein uS2 family
HTZ78_09345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HTZ78_09355	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HTZ78_09370	COG1160	GTP binding
HTZ78_09380	COG0457	Tetratricopeptide repeat
HTZ78_09385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HTZ78_09390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HTZ78_09395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HTZ78_09460	COG2165	general secretion pathway protein
HTZ78_09465	COG4106	trans-aconitate 2-methyltransferase activity
HTZ78_09470	COG1357	PFAM Pentapeptide repeats (8 copies)
HTZ78_09475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HTZ78_09480	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HTZ78_09485	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HTZ78_09495	COG2199	diguanylate cyclase activity
HTZ78_09500	COG0750	zinc metalloprotease
HTZ78_09505	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HTZ78_09515	COG0590	tRNA wobble adenosine to inosine editing
HTZ78_09525	COG0415	Belongs to the DNA photolyase family
HTZ78_09540	COG3409	Peptidoglycan-binding domain 1 protein
HTZ78_09540	COG3429	Glucose-6-phosphate dehydrogenase subunit
HTZ78_09550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HTZ78_09590	COG2886	Uncharacterised protein family (UPF0175)
HTZ78_09600	COG0745	RESPONSE REGULATOR receiver
HTZ78_09650	COG1122	ATPase activity
HTZ78_09655	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HTZ78_09675	COG0069	glutamate synthase activity
HTZ78_09675	COG0067	glutamate synthase
HTZ78_09675	COG0070	glutamate synthase
HTZ78_09685	COG0047	phosphoribosylformylglycinamidine synthase activity
HTZ78_09690	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HTZ78_09695	COG0456	acetyltransferase
HTZ78_09705	COG2205	protein histidine kinase activity
HTZ78_09710	COG1357	PFAM Pentapeptide repeats (8 copies)
HTZ78_09720	COG1840	ABC-type Fe3 transport system, periplasmic component
HTZ78_09725	COG0811	peptide transport
HTZ78_09740	COG0251	oxidation-reduction process
HTZ78_09745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HTZ78_09750	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HTZ78_09755	COG0392	lysyltransferase activity
HTZ78_09780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HTZ78_09790	COG0343	queuine tRNA-ribosyltransferase activity
HTZ78_09810	COG2886	Uncharacterised protein family (UPF0175)
HTZ78_09815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HTZ78_09820	COG0668	transmembrane transport
HTZ78_09825	COG0205	6-phosphofructokinase activity
HTZ78_09840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HTZ78_09840	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HTZ78_09840	COG0674	pyruvate-flavodoxin oxidoreductase activity
HTZ78_09840	COG1013	pyruvate-flavodoxin oxidoreductase activity
HTZ78_09850	COG3842	ATPase activity
HTZ78_09855	COG0725	ABC transporter, periplasmic molybdate-binding protein
HTZ78_09880	COG0438	transferase activity, transferring glycosyl groups
HTZ78_09895	COG0643	Histidine kinase
HTZ78_09895	COG2198	Histidine kinase
HTZ78_09895	COG0784	Response regulator, receiver
HTZ78_09905	COG2203	Gaf domain
HTZ78_09905	COG0840	transmembrane signaling receptor activity
HTZ78_09920	COG0784	Response regulator, receiver
HTZ78_09930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HTZ78_09935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HTZ78_09940	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HTZ78_09945	COG1803	Methylglyoxal synthase
HTZ78_09945	COG1597	lipid kinase activity
HTZ78_09950	COG0436	Aminotransferase
HTZ78_10035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HTZ78_10080	COG0857	belongs to the CobB CobQ family
HTZ78_10085	COG0583	DNA-binding transcription factor activity
HTZ78_10090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HTZ78_10095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HTZ78_10100	COG3659	wide pore channel activity
HTZ78_10105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HTZ78_10105	COG1116	anion transmembrane transporter activity
HTZ78_10110	COG1116	anion transmembrane transporter activity
HTZ78_10170	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HTZ78_10175	COG0571	ribonuclease III activity
HTZ78_10195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HTZ78_10200	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HTZ78_10215	COG0628	permease
HTZ78_10220	COG0149	triose-phosphate isomerase activity
HTZ78_10230	COG2205	protein histidine kinase activity
HTZ78_10235	COG1231	oxidoreductase activity
HTZ78_10245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HTZ78_10255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HTZ78_10260	COG0450	alkyl hydroperoxide reductase
HTZ78_10270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HTZ78_10280	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HTZ78_10290	COG1131	(ABC) transporter
HTZ78_10320	COG0439	Biotin carboxylase
HTZ78_10330	COG0590	tRNA wobble adenosine to inosine editing
HTZ78_10335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HTZ78_10350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HTZ78_10365	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HTZ78_10370	COG4251	negative regulation of phosphorylation
HTZ78_10375	COG0784	Response regulator, receiver
HTZ78_10380	COG1032	radical SAM domain protein
HTZ78_10385	COG0167	dihydroorotate dehydrogenase activity
HTZ78_10390	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HTZ78_10395	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTZ78_10400	COG0839	Belongs to the complex I subunit 6 family
HTZ78_10405	COG0713	ATP synthesis coupled electron transport
HTZ78_10415	COG0525	valine-tRNA ligase activity
HTZ78_10430	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HTZ78_10435	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HTZ78_10460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HTZ78_10465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HTZ78_10470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HTZ78_10480	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HTZ78_10485	COG5001	Diguanylate cyclase
HTZ78_10485	COG1716	ATPase activity
HTZ78_10490	COG3631	Ketosteroid isomerase-related protein
HTZ78_10500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HTZ78_10500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HTZ78_10510	COG0107	imidazoleglycerol-phosphate synthase activity
HTZ78_10515	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HTZ78_10520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HTZ78_10525	COG0438	transferase activity, transferring glycosyl groups
HTZ78_10570	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HTZ78_10580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HTZ78_10585	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HTZ78_10595	COG0514	ATP-dependent DNA helicase (RecQ)
HTZ78_10610	COG0776	regulation of translation
HTZ78_10625	COG0668	transmembrane transport
HTZ78_10630	COG0668	transmembrane transport
HTZ78_10650	COG1754	DNA topoisomerase type I activity
HTZ78_10650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HTZ78_10655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HTZ78_10660	COG0640	Transcriptional regulator
HTZ78_10665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HTZ78_10680	COG2188	Transcriptional regulator
HTZ78_10700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HTZ78_10710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTZ78_10720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HTZ78_10730	COG0831	urea catabolic process
HTZ78_10735	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HTZ78_10740	COG1562	ergosterol biosynthetic process
HTZ78_10745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HTZ78_10745	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HTZ78_10775	COG2154	pterin-4-alpha-carbinolamine dehydratase
HTZ78_10780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HTZ78_10790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HTZ78_10805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HTZ78_10810	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HTZ78_10815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HTZ78_10875	COG1187	pseudouridine synthase activity
HTZ78_10880	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HTZ78_10910	COG1012	belongs to the aldehyde dehydrogenase family
HTZ78_10915	COG3384	dioxygenase
HTZ78_10930	COG3659	wide pore channel activity
HTZ78_10935	COG0745	RESPONSE REGULATOR receiver
HTZ78_10940	COG0860	N-Acetylmuramoyl-L-alanine amidase
HTZ78_10940	COG2247	cell wall binding repeat
HTZ78_11010	COG0768	penicillin binding
HTZ78_11020	COG0247	lactate metabolic process
HTZ78_11030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HTZ78_11035	COG0583	DNA-binding transcription factor activity
HTZ78_11045	COG0384	phenazine biosynthesis protein PhzF
HTZ78_11055	COG0606	chelatase, subunit chli
HTZ78_11065	COG0314	molybdopterin synthase activity
HTZ78_11075	COG0315	cyclic pyranopterin monophosphate synthase activity
HTZ78_11075	COG0746	molybdenum cofactor guanylyltransferase activity
HTZ78_11080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HTZ78_11085	COG0303	'Molybdopterin
HTZ78_11090	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HTZ78_11100	COG1480	7TM receptor with intracellular HD hydrolase
HTZ78_11110	COG0800	Aldolase
HTZ78_11115	COG0004	ammonium transporteR
HTZ78_11120	COG5001	Diguanylate cyclase
HTZ78_11120	COG3300	MHYT domain
HTZ78_11145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HTZ78_11160	COG0628	permease
HTZ78_11175	COG0066	3-isopropylmalate dehydratase activity
HTZ78_11180	COG0504	CTP synthase activity
HTZ78_11195	COG2204	response regulator
HTZ78_11205	COG0259	pyridoxamine-phosphate oxidase activity
HTZ78_11225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HTZ78_11245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HTZ78_11250	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HTZ78_11260	COG0300	oxidoreductase activity
HTZ78_11280	COG0798	PFAM Bile acid sodium symporter
HTZ78_11285	COG0431	NADPH-dependent FMN reductase
HTZ78_11290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HTZ78_11315	COG3064	Membrane
HTZ78_11315	COG0515	serine threonine protein kinase
HTZ78_11315	COG4991	sh3 domain protein
HTZ78_11325	COG4636	protein conserved in cyanobacteria
HTZ78_11340	COG1657	PFAM Prenyltransferase squalene oxidase
HTZ78_11355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HTZ78_11360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HTZ78_11390	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HTZ78_11395	COG0129	dihydroxy-acid dehydratase activity
HTZ78_11405	COG4581	dead DEAH box helicase
HTZ78_11435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HTZ78_11450	COG0386	Belongs to the glutathione peroxidase family
HTZ78_11455	COG2119	membrane
HTZ78_11465	COG0371	Dehydrogenase
HTZ78_11470	COG0644	oxidoreductase
HTZ78_11495	COG2267	carboxylic ester hydrolase activity
HTZ78_11505	COG3842	ATPase activity
HTZ78_11510	COG1090	epimerase
HTZ78_11535	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HTZ78_11545	COG0275	rRNA processing
HTZ78_11555	COG0793	Belongs to the peptidase S41A family
HTZ78_11565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HTZ78_11570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HTZ78_11580	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HTZ78_11585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HTZ78_11590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HTZ78_11595	COG1116	anion transmembrane transporter activity
HTZ78_11595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HTZ78_11600	COG1116	anion transmembrane transporter activity
HTZ78_11610	COG0243	molybdopterin cofactor binding
HTZ78_11635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HTZ78_11645	COG0242	peptide deformylase activity
HTZ78_11650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HTZ78_11665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HTZ78_11670	COG1131	(ABC) transporter
HTZ78_11680	COG0830	nickel cation binding
HTZ78_11685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HTZ78_11695	COG2010	Cytochrome c
HTZ78_11715	COG0783	Belongs to the Dps family
HTZ78_11720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HTZ78_11725	COG0088	Forms part of the polypeptide exit tunnel
HTZ78_11730	COG0089	rRNA binding
HTZ78_11735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HTZ78_11740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HTZ78_11745	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HTZ78_11750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HTZ78_11755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HTZ78_11760	COG0255	Belongs to the universal ribosomal protein uL29 family
HTZ78_11765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HTZ78_11770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HTZ78_11775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HTZ78_11780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HTZ78_11785	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HTZ78_11790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HTZ78_11795	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HTZ78_11800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HTZ78_11805	COG0200	Binds to the 23S rRNA
HTZ78_11810	COG0201	protein transport
HTZ78_11815	COG0563	adenylate kinase activity
HTZ78_11820	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HTZ78_11825	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HTZ78_11830	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HTZ78_11835	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HTZ78_11840	COG0202	RNA polymerase activity
HTZ78_11845	COG0203	ribosomal protein L17
HTZ78_11850	COG0101	tRNA pseudouridine synthase activity
HTZ78_11855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HTZ78_11860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HTZ78_11865	COG0254	rRNA binding
HTZ78_11880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HTZ78_11885	COG5002	protein histidine kinase activity
HTZ78_11890	COG1192	Involved in chromosome partitioning
HTZ78_11905	COG0745	RESPONSE REGULATOR receiver
HTZ78_11920	COG1612	heme a metabolic process
HTZ78_11925	COG0109	protoheme IX farnesyltransferase activity
HTZ78_11930	COG0298	carbon dioxide binding
HTZ78_11955	COG1032	radical SAM domain protein
HTZ78_11965	COG0359	binds to the 23S rRNA
HTZ78_11970	COG2010	Cytochrome c
HTZ78_11975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HTZ78_11980	COG1672	PFAM Archaeal ATPase
HTZ78_11985	COG3239	Fatty acid desaturase
HTZ78_11990	COG0166	Belongs to the GPI family
HTZ78_11995	COG1045	serine acetyltransferase
HTZ78_12000	COG0288	reversible hydration of carbon dioxide
HTZ78_12005	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HTZ78_12005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HTZ78_12045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HTZ78_12055	COG1473	amidohydrolase
HTZ78_12080	COG2304	oxidoreductase activity
HTZ78_12090	COG2211	Major facilitator Superfamily
HTZ78_12105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HTZ78_12110	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTZ78_12115	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTZ78_12120	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTZ78_12125	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HTZ78_12130	COG0037	tRNA processing
HTZ78_12170	COG3659	wide pore channel activity
HTZ78_12185	COG0405	Gamma-glutamyltransferase
HTZ78_12190	COG0772	Belongs to the SEDS family
HTZ78_12200	COG2192	nodulation
HTZ78_12205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HTZ78_12210	COG2274	protein secretion by the type I secretion system
HTZ78_12215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HTZ78_12220	COG0723	plastoquinol--plastocyanin reductase activity
HTZ78_12235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HTZ78_12265	COG2239	Acts as a magnesium transporter
HTZ78_12275	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HTZ78_12285	COG0784	Response regulator, receiver
HTZ78_12290	COG0745	RESPONSE REGULATOR receiver
HTZ78_12295	COG3706	GGDEF domain
HTZ78_12295	COG4251	negative regulation of phosphorylation
HTZ78_12295	COG5001	Diguanylate cyclase
HTZ78_12295	COG2203	Gaf domain
HTZ78_12315	COG1028	Short-chain dehydrogenase reductase Sdr
HTZ78_12315	COG3347	Dehydrogenase
HTZ78_12350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HTZ78_12360	COG1175	transmembrane transport
HTZ78_12375	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HTZ78_12380	COG0450	alkyl hydroperoxide reductase
HTZ78_12395	COG0393	Putative heavy-metal-binding
HTZ78_12400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HTZ78_12400	COG0758	DNA mediated transformation
HTZ78_12420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HTZ78_12425	COG1196	nuclear chromosome segregation
HTZ78_12430	COG3128	pkhd-type hydroxylase
HTZ78_12435	COG0113	porphobilinogen synthase activity
HTZ78_12440	COG0803	Belongs to the bacterial solute-binding protein 9 family
HTZ78_12445	COG1121	(ABC) transporter
HTZ78_12450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HTZ78_12455	COG0523	cobalamin synthesis protein
HTZ78_12460	COG0302	gtp cyclohydrolase
HTZ78_12490	COG5002	protein histidine kinase activity
HTZ78_12495	COG0268	Binds directly to 16S ribosomal RNA
HTZ78_12500	COG0084	hydrolase, TatD family'
HTZ78_12505	COG0085	RNA polymerase activity
HTZ78_12510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HTZ78_12550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HTZ78_12565	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HTZ78_12575	COG0741	lytic transglycosylase activity
HTZ78_12580	COG2205	protein histidine kinase activity
HTZ78_12590	COG0395	ABC-type sugar transport system, permease component
HTZ78_12595	COG1175	transmembrane transport
HTZ78_12600	COG1653	transport
HTZ78_12605	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HTZ78_12610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HTZ78_12615	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HTZ78_12620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HTZ78_12625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HTZ78_12630	COG0724	RNA recognition motif
HTZ78_12640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HTZ78_12645	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTZ78_12660	COG0151	Belongs to the GarS family
HTZ78_12670	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HTZ78_12675	COG0049	tRNA binding
HTZ78_12680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HTZ78_12685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HTZ78_12690	COG0051	transcription antitermination factor activity, RNA binding
HTZ78_12700	COG1192	Involved in chromosome partitioning
HTZ78_12710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HTZ78_12725	COG1357	PFAM Pentapeptide repeats (8 copies)
HTZ78_12730	COG1619	proteins homologs of microcin C7 resistance protein MccF
HTZ78_12740	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HTZ78_12745	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HTZ78_12745	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HTZ78_12750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HTZ78_12755	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HTZ78_12775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HTZ78_12780	COG0222	ribosome binding
HTZ78_12785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HTZ78_12790	COG0081	regulation of translation
HTZ78_12795	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HTZ78_12800	COG0250	Participates in transcription elongation, termination and antitermination
HTZ78_12805	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HTZ78_12815	COG0335	large ribosomal subunit rRNA binding
HTZ78_12845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HTZ78_12855	COG3243	poly(R)-hydroxyalkanoic acid synthase
HTZ78_12865	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HTZ78_12875	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTZ78_12880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HTZ78_12890	COG2885	chlorophyll binding
HTZ78_12895	COG2885	chlorophyll binding
HTZ78_12920	COG0022	dehydrogenase e1 component
HTZ78_12920	COG0508	dehydrogenase complex catalyzes the overall conversion of
HTZ78_12925	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HTZ78_12930	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HTZ78_12935	COG1929	Belongs to the glycerate kinase type-1 family
HTZ78_12940	COG3659	wide pore channel activity
HTZ78_12945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HTZ78_12950	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HTZ78_12970	COG0495	leucyl-tRNA aminoacylation
HTZ78_12975	COG0786	glutamate:sodium symporter activity
HTZ78_13005	COG1606	tRNA processing
HTZ78_13015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HTZ78_13020	COG2045	Belongs to the ComB family
HTZ78_13025	COG0778	Nitroreductase
HTZ78_13030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HTZ78_13040	COG0516	GMP reductase activity
HTZ78_13045	COG0395	ABC-type sugar transport system, permease component
HTZ78_13070	COG0189	ligase activity
HTZ78_13070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HTZ78_13075	COG4242	Belongs to the peptidase S51 family
HTZ78_13100	COG1028	Short-chain dehydrogenase reductase Sdr
HTZ78_13105	COG0183	Belongs to the thiolase family
HTZ78_13110	COG0386	Belongs to the glutathione peroxidase family
HTZ78_13125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HTZ78_13130	COG2264	protein methyltransferase activity
HTZ78_13160	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HTZ78_13165	COG2852	Protein conserved in bacteria
HTZ78_13175	COG1136	(ABC) transporter
HTZ78_13190	COG1819	glycosyl
HTZ78_13195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HTZ78_13210	COG0438	transferase activity, transferring glycosyl groups
HTZ78_13215	COG0488	(ABC) transporter
HTZ78_13225	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HTZ78_13245	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HTZ78_13250	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HTZ78_13255	COG0561	phosphatase activity
HTZ78_13260	COG1366	Belongs to the anti-sigma-factor antagonist family
HTZ78_13265	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HTZ78_13270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HTZ78_13280	COG0215	cysteine-tRNA ligase activity
HTZ78_13285	COG0424	maF-like protein
HTZ78_13300	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HTZ78_13325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HTZ78_13330	COG1799	cell septum assembly
HTZ78_13335	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HTZ78_13335	COG0662	Cupin 2, conserved barrel domain protein
HTZ78_13345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HTZ78_13350	COG0459	protein refolding
HTZ78_13360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HTZ78_13370	COG2140	Oxalate decarboxylase
HTZ78_13375	COG0058	SHG alpha-glucan phosphorylase activity
HTZ78_13385	COG0515	serine threonine protein kinase
HTZ78_13405	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HTZ78_13405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HTZ78_13410	COG2205	protein histidine kinase activity
HTZ78_13410	COG3437	response regulator, receiver
HTZ78_13410	COG3850	Histidine kinase
HTZ78_13410	COG4999	Histidine kinase
HTZ78_13440	COG0546	phosphoglycolate phosphatase activity
HTZ78_13445	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HTZ78_13450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HTZ78_13465	COG0501	Belongs to the peptidase M48B family
HTZ78_13470	COG0539	negative regulation of cytoplasmic translation
HTZ78_13475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HTZ78_13480	COG1132	(ABC) transporter
HTZ78_13485	COG0469	pyruvate kinase activity
HTZ78_13505	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HTZ78_13510	COG1268	BioY protein
HTZ78_13515	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HTZ78_13535	COG1104	cysteine desulfurase activity
HTZ78_13545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HTZ78_13550	COG1061	Type III restriction enzyme res subunit
HTZ78_13560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HTZ78_13560	COG0519	Catalyzes the synthesis of GMP from XMP
HTZ78_13580	COG1492	cobalamin metabolic process
HTZ78_13585	COG0025	NhaP-type Na H and K H
HTZ78_13590	COG0583	DNA-binding transcription factor activity
HTZ78_13620	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HTZ78_13630	COG5398	heme oxygenase
HTZ78_13635	COG0408	coproporphyrinogen oxidase activity
HTZ78_13645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HTZ78_13675	COG0277	FAD linked oxidase domain protein
HTZ78_13680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HTZ78_13705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HTZ78_13710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HTZ78_13720	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HTZ78_13735	COG1555	photosystem II stabilization
HTZ78_13740	COG1289	transmembrane transporter activity
HTZ78_13745	COG0205	6-phosphofructokinase activity
HTZ78_13755	COG0336	Belongs to the RNA methyltransferase TrmD family
HTZ78_13760	COG1840	ABC-type Fe3 transport system, periplasmic component
HTZ78_13780	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTZ78_13795	COG4636	protein conserved in cyanobacteria
HTZ78_13800	COG0538	isocitrate dehydrogenase activity
HTZ78_13810	COG2226	methyltransferase
HTZ78_13815	COG0589	response to stress
HTZ78_13845	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HTZ78_13860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HTZ78_13940	COG0375	protein maturation
HTZ78_13955	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HTZ78_13960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HTZ78_13965	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HTZ78_13975	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HTZ78_13985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HTZ78_14005	COG0312	modulator of DNA gyrase
HTZ78_14015	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HTZ78_14035	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HTZ78_14055	COG0189	ligase activity
HTZ78_14060	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HTZ78_14070	COG2267	carboxylic ester hydrolase activity
HTZ78_14085	COG0402	S-adenosylhomocysteine deaminase activity
HTZ78_14120	COG0537	adenosine 5'-monophosphoramidase activity
HTZ78_14145	COG1233	COG1233 Phytoene dehydrogenase and related
HTZ78_14150	COG0589	response to stress
HTZ78_14155	COG0659	secondary active sulfate transmembrane transporter activity
HTZ78_14160	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HTZ78_14165	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HTZ78_14170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HTZ78_14180	COG0515	serine threonine protein kinase
HTZ78_14190	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HTZ78_14225	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HTZ78_14235	COG0747	negative chemotaxis
HTZ78_14245	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HTZ78_14250	COG0596	Alpha beta hydrolase
HTZ78_14260	COG0616	signal peptide processing
HTZ78_14270	COG3706	GGDEF domain
HTZ78_14270	COG4251	negative regulation of phosphorylation
HTZ78_14270	COG5001	Diguanylate cyclase
HTZ78_14270	COG2203	Gaf domain
HTZ78_14275	COG2197	response regulator
HTZ78_14305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HTZ78_14330	COG2886	Uncharacterised protein family (UPF0175)
HTZ78_14350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HTZ78_14365	COG0443	Heat shock 70 kDa protein
HTZ78_14375	COG0646	methionine synthase
HTZ78_14375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HTZ78_14395	COG0187	DNA topoisomerase II activity
HTZ78_14395	COG1372	Participates in initiation and elongation during chromosome replication
HTZ78_14410	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HTZ78_14420	COG0612	Peptidase, M16
HTZ78_14425	COG0612	Peptidase, M16
HTZ78_14430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HTZ78_14435	COG0602	queuosine metabolic process
HTZ78_14440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HTZ78_14450	COG1489	DNA binding
HTZ78_14460	COG0280	phosphate acetyltransferase
HTZ78_14460	COG0857	belongs to the CobB CobQ family
HTZ78_14465	COG0427	acetyl-CoA hydrolase
HTZ78_14470	COG0181	hydroxymethylbilane synthase activity
HTZ78_14480	COG0799	negative regulation of ribosome biogenesis
HTZ78_14495	COG0180	Tryptophanyl-tRNA synthetase
HTZ78_14515	COG0196	riboflavin kinase activity
HTZ78_14525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTZ78_14530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HTZ78_14540	COG0083	homoserine kinase activity
HTZ78_14575	COG0641	radical SAM
HTZ78_14580	COG1413	lyase activity
HTZ78_14585	COG0179	Fumarylacetoacetate (FAA) hydrolase
HTZ78_14590	COG0360	Binds together with S18 to 16S ribosomal RNA
HTZ78_14600	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HTZ78_14605	COG3932	Exopolysaccharide synthesis, ExoD
HTZ78_14610	COG1181	Belongs to the D-alanine--D-alanine ligase family
HTZ78_14630	COG3937	granule-associated protein
HTZ78_14645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HTZ78_14650	COG0631	protein serine/threonine phosphatase activity
HTZ78_14655	COG1193	negative regulation of DNA recombination
HTZ78_14665	COG1741	Belongs to the pirin family
HTZ78_14700	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HTZ78_14705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HTZ78_14740	COG2208	phosphoserine phosphatase activity
HTZ78_14740	COG2770	Histidine kinase
HTZ78_14755	COG1366	Belongs to the anti-sigma-factor antagonist family
HTZ78_14770	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HTZ78_14780	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HTZ78_14800	COG1082	Xylose isomerase domain protein TIM barrel
HTZ78_14820	COG2319	Wd-40 repeat
HTZ78_14825	COG2319	Wd-40 repeat
HTZ78_14840	COG1028	Short-chain dehydrogenase reductase Sdr
HTZ78_14845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HTZ78_14870	COG0723	plastoquinol--plastocyanin reductase activity
HTZ78_14875	COG3258	Cytochrome c
HTZ78_14885	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HTZ78_14910	COG0322	excinuclease ABC activity
HTZ78_14920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HTZ78_14935	COG1028	Short-chain dehydrogenase reductase Sdr
HTZ78_14940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HTZ78_15010	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HTZ78_15015	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HTZ78_15025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HTZ78_15040	COG1316	TRANSCRIPTIONal
HTZ78_15060	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HTZ78_15085	COG0509	glycine decarboxylation via glycine cleavage system
HTZ78_15090	COG0739	heme binding
HTZ78_15095	COG0154	amidase activity
HTZ78_15100	COG0724	RNA recognition motif
HTZ78_15110	COG1836	PFAM Integral membrane protein DUF92
HTZ78_15115	COG0632	four-way junction helicase activity
HTZ78_15120	COG1970	mechanosensitive ion channel activity
HTZ78_15140	COG0575	Belongs to the CDS family
HTZ78_15150	COG0058	SHG alpha-glucan phosphorylase activity
HTZ78_15160	COG0765	amino acid transport
HTZ78_15165	COG3659	wide pore channel activity
HTZ78_15170	COG3300	MHYT domain
HTZ78_15170	COG5001	Diguanylate cyclase
HTZ78_15190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HTZ78_15195	COG0443	Heat shock 70 kDa protein
HTZ78_15200	COG0484	heat shock protein binding
HTZ78_15220	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HTZ78_15235	COG1702	phosphate starvation-inducible protein PhoH
HTZ78_15250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HTZ78_15255	COG1121	(ABC) transporter
HTZ78_15290	COG3228	Belongs to the MtfA family
HTZ78_15295	COG0784	Response regulator, receiver
HTZ78_15300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HTZ78_15340	COG2319	Wd-40 repeat
HTZ78_15345	COG1587	Uroporphyrinogen-III synthase
HTZ78_15365	COG0443	Heat shock 70 kDa protein
HTZ78_15370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HTZ78_15375	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HTZ78_15385	COG1937	Protein conserved in bacteria
HTZ78_15395	COG0517	IMP dehydrogenase activity
HTZ78_15395	COG0516	GMP reductase activity
HTZ78_15410	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HTZ78_15445	COG2202	Pas domain
HTZ78_15445	COG2205	protein histidine kinase activity
HTZ78_15460	COG4783	chaperone-mediated protein folding
HTZ78_15465	COG3850	Histidine kinase
HTZ78_15465	COG2205	protein histidine kinase activity
HTZ78_15465	COG3437	response regulator, receiver
HTZ78_15465	COG4999	Histidine kinase
HTZ78_15475	COG4956	integral membrane protein (PIN domain superfamily)
HTZ78_15490	COG1160	GTP binding
HTZ78_15500	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HTZ78_15515	COG0432	Pfam Uncharacterised protein family UPF0047
HTZ78_15520	COG2197	response regulator
HTZ78_15535	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HTZ78_15540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HTZ78_15550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HTZ78_15555	COG5398	heme oxygenase
HTZ78_15560	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HTZ78_15570	COG1316	TRANSCRIPTIONal
HTZ78_15585	COG2208	phosphoserine phosphatase activity
HTZ78_15585	COG2770	Histidine kinase
HTZ78_15590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HTZ78_15600	COG0539	negative regulation of cytoplasmic translation
HTZ78_15605	COG0358	DNA primase activity
HTZ78_15615	COG0009	L-threonylcarbamoyladenylate synthase
HTZ78_15635	COG0589	response to stress
HTZ78_15650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HTZ78_15670	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HTZ78_15675	COG0594	ribonuclease P activity
HTZ78_15685	COG0706	membrane insertase activity
HTZ78_15695	COG0484	heat shock protein binding
HTZ78_15700	COG0483	inositol monophosphate 1-phosphatase activity
HTZ78_15705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HTZ78_15720	COG0791	NLP P60 protein
HTZ78_15740	COG0540	Belongs to the ATCase OTCase family
HTZ78_15770	COG1215	transferase activity, transferring glycosyl groups
HTZ78_15780	COG0300	oxidoreductase activity
HTZ78_15780	COG3000	fatty acid hydroxylase
HTZ78_15800	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HTZ78_15805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HTZ78_15810	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HTZ78_15815	COG0463	Glycosyl transferase, family 2
HTZ78_15820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HTZ78_15835	COG1472	Belongs to the glycosyl hydrolase 3 family
HTZ78_15845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HTZ78_15850	COG1280	lysine exporter protein (LysE YggA)
HTZ78_15865	COG0564	pseudouridine synthase activity
HTZ78_15875	COG0438	transferase activity, transferring glycosyl groups
HTZ78_15915	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HTZ78_15940	COG0500	methyltransferase
HTZ78_15945	COG0542	response to heat
HTZ78_15955	COG0572	uridine kinase
HTZ78_15960	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HTZ78_15965	COG0561	phosphatase activity
HTZ78_15980	COG0571	ribonuclease III activity
HTZ78_15985	COG0390	transport system, permease component
HTZ78_15990	COG0668	transmembrane transport
HTZ78_15995	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HTZ78_16005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HTZ78_16010	COG0426	domain, Protein
HTZ78_16010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HTZ78_16020	COG0126	phosphoglycerate kinase activity
HTZ78_16025	COG0583	DNA-binding transcription factor activity
HTZ78_16030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HTZ78_16065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HTZ78_16080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HTZ78_16085	COG0347	Belongs to the P(II) protein family
HTZ78_16100	COG0135	phosphoribosylanthranilate isomerase activity
HTZ78_16105	COG0697	spore germination
HTZ78_16115	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HTZ78_16130	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HTZ78_16135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HTZ78_16150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HTZ78_16185	COG0310	cobalt ion transport
HTZ78_16195	COG1122	ATPase activity
HTZ78_16205	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HTZ78_16215	COG0475	glutathione-regulated potassium exporter activity
HTZ78_16215	COG0589	response to stress
HTZ78_16225	COG0406	alpha-ribazole phosphatase activity
HTZ78_16230	COG0745	RESPONSE REGULATOR receiver
HTZ78_16240	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HTZ78_16250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HTZ78_16280	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HTZ78_16285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HTZ78_16300	COG2211	Major facilitator Superfamily
HTZ78_16320	COG5002	protein histidine kinase activity
HTZ78_16325	COG0668	transmembrane transport
HTZ78_16330	COG0752	glycyl-tRNA synthetase alpha subunit
HTZ78_16345	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HTZ78_16355	COG0354	folic acid binding
HTZ78_16360	COG0583	DNA-binding transcription factor activity
HTZ78_16390	COG0697	spore germination
HTZ78_16420	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HTZ78_16430	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HTZ78_16435	COG3339	Conserved Protein
HTZ78_16445	COG0312	modulator of DNA gyrase
HTZ78_16450	COG0482	sulfurtransferase activity
HTZ78_16465	COG0488	(ABC) transporter
HTZ78_16480	COG0284	orotidine-5'-phosphate decarboxylase activity
HTZ78_16515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HTZ78_16515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HTZ78_16525	COG0517	IMP dehydrogenase activity
HTZ78_16525	COG1994	Peptidase M50
HTZ78_16530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HTZ78_16545	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HTZ78_16550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HTZ78_16555	COG1845	cytochrome c oxidase, subunit III
HTZ78_16560	COG3118	belongs to the thioredoxin family
HTZ78_16565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HTZ78_16570	COG1116	anion transmembrane transporter activity
HTZ78_16575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HTZ78_16590	COG0375	protein maturation
HTZ78_16595	COG0010	Belongs to the arginase family
HTZ78_16630	COG1234	tRNA 3'-trailer cleavage
HTZ78_16640	COG3794	PFAM blue (type 1) copper domain protein
HTZ78_16650	COG0445	tRNA wobble uridine modification
HTZ78_16660	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HTZ78_16670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HTZ78_16675	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HTZ78_16680	COG0805	protein transport
HTZ78_16690	COG2084	Dehydrogenase
HTZ78_16695	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HTZ78_16705	COG1132	(ABC) transporter
HTZ78_16745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HTZ78_16765	COG2046	Belongs to the sulfate adenylyltransferase family
HTZ78_16770	COG0438	transferase activity, transferring glycosyl groups
HTZ78_16780	COG0737	Belongs to the 5'-nucleotidase family
HTZ78_16795	COG2361	Protein of unknown function DUF86
HTZ78_16805	COG2361	Protein of unknown function DUF86
HTZ78_16830	COG1487	ribonuclease activity
HTZ78_16840	COG4115	mRNA cleavage
HTZ78_16875	COG0070	glutamate synthase
HTZ78_16875	COG0069	glutamate synthase activity
HTZ78_16875	COG0067	glutamate synthase
HTZ78_16885	COG0515	serine threonine protein kinase
HTZ78_16900	COG2133	pyrroloquinoline quinone binding
HTZ78_16905	COG1797	cobyrinic acid a,c-diamide synthase activity
HTZ78_16910	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HTZ78_16915	COG1022	Amp-dependent synthetase and ligase
HTZ78_16920	COG0784	Response regulator, receiver
HTZ78_16935	COG2203	Gaf domain
HTZ78_16935	COG0840	transmembrane signaling receptor activity
HTZ78_16940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HTZ78_16945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HTZ78_16950	COG2203	Gaf domain
HTZ78_16950	COG3706	GGDEF domain
HTZ78_16950	COG4251	negative regulation of phosphorylation
HTZ78_16950	COG5001	Diguanylate cyclase
HTZ78_16960	COG0419	ATPase involved in DNA repair
HTZ78_16965	COG0484	heat shock protein binding
HTZ78_16970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HTZ78_16980	COG2314	TM2 domain
HTZ78_17005	COG0017	Asparaginyl-tRNA synthetase
HTZ78_17025	COG0569	domain protein
HTZ78_17030	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HTZ78_17035	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HTZ78_17040	COG0629	single-stranded DNA binding
HTZ78_17050	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HTZ78_17060	COG1192	Involved in chromosome partitioning
HTZ78_17070	COG2119	membrane
HTZ78_17075	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HTZ78_17080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HTZ78_17090	COG1162	GTPase activity
HTZ78_17100	COG0484	heat shock protein binding
HTZ78_17105	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HTZ78_17110	COG1218	3'(2'),5'-bisphosphate nucleotidase
HTZ78_17115	COG0134	indole-3-glycerol-phosphate synthase activity
HTZ78_17120	COG0004	ammonium transporteR
HTZ78_17125	COG0569	domain protein
HTZ78_17140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HTZ78_17145	COG0740	serine-type endopeptidase activity
HTZ78_17150	COG0544	peptidyl-prolyl cis-trans isomerase activity
HTZ78_17155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HTZ78_17160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HTZ78_17165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HTZ78_17175	COG0237	dephospho-CoA kinase activity
HTZ78_17190	COG1234	tRNA 3'-trailer cleavage
HTZ78_17200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HTZ78_17215	COG0631	protein serine/threonine phosphatase activity
HTZ78_17220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HTZ78_17230	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HTZ78_17235	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HTZ78_17240	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HTZ78_17245	COG0493	'glutamate synthase
HTZ78_17250	COG3659	wide pore channel activity
HTZ78_17275	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HTZ78_17275	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HTZ78_17345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HTZ78_17380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HTZ78_17445	COG2197	response regulator
HTZ78_17450	COG4585	Histidine kinase
HTZ78_17465	COG1902	pentaerythritol trinitrate reductase activity
HTZ78_17470	COG0508	dehydrogenase complex catalyzes the overall conversion of
HTZ78_17470	COG0596	Alpha beta hydrolase
HTZ78_17485	COG2124	cytochrome p450
HTZ78_17520	COG1846	Transcriptional regulator
HTZ78_17530	COG1028	Short-chain dehydrogenase reductase Sdr
HTZ78_17540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HTZ78_17580	COG1518	maintenance of DNA repeat elements
HTZ78_17580	COG1468	defense response to virus
HTZ78_17725	COG0270	DNA (cytosine-5-)-methyltransferase activity
HTZ78_17740	COG0702	epimerase
HTZ78_17795	COG2340	Cysteine-rich secretory protein family
HTZ78_17860	COG1404	Belongs to the peptidase S8 family
HTZ78_17865	COG0464	growth
HTZ78_17885	COG3961	Belongs to the TPP enzyme family
HTZ78_17915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HTZ78_17935	COG2211	Major facilitator Superfamily