locus-tag	class	description
IQE94_00010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IQE94_00015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IQE94_00025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IQE94_00030	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IQE94_00040	COG0731	radical SAM domain protein
IQE94_00045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IQE94_00055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IQE94_00060	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IQE94_00065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IQE94_00070	COG0271	Belongs to the BolA IbaG family
IQE94_00090	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IQE94_00105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IQE94_00135	COG0222	ribosome binding
IQE94_00145	COG2066	Belongs to the glutaminase family
IQE94_00160	COG0287	Prephenate dehydrogenase
IQE94_00165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IQE94_00180	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IQE94_00185	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IQE94_00190	COG1333	cytochrome c biogenesis protein
IQE94_00200	COG0668	transmembrane transport
IQE94_00230	COG0436	Aminotransferase
IQE94_00235	COG0372	Belongs to the citrate synthase family
IQE94_00240	COG2062	phosphohistidine phosphatase, SixA
IQE94_00245	COG0596	Alpha beta hydrolase
IQE94_00260	COG1234	tRNA 3'-trailer cleavage
IQE94_00280	COG0788	formyltetrahydrofolate deformylase activity
IQE94_00300	COG0625	glutathione transferase activity
IQE94_00310	COG0440	acetolactate synthase activity
IQE94_00320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IQE94_00325	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IQE94_00335	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IQE94_00350	COG0628	permease
IQE94_00385	COG0628	permease
IQE94_00390	COG0443	Heat shock 70 kDa protein
IQE94_00395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IQE94_00405	COG0116	Belongs to the methyltransferase superfamily
IQE94_00415	COG0552	protein localization to endoplasmic reticulum
IQE94_00425	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IQE94_00445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IQE94_00450	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IQE94_00465	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IQE94_00475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IQE94_00480	COG0673	inositol 2-dehydrogenase activity
IQE94_00495	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IQE94_00510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IQE94_00515	COG0114	fumarate hydratase activity
IQE94_00540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IQE94_00555	COG1253	flavin adenine dinucleotide binding
IQE94_00565	COG3046	protein related to deoxyribodipyrimidine photolyase
IQE94_00570	COG0517	IMP dehydrogenase activity
IQE94_00570	COG0617	tRNA 3'-terminal CCA addition
IQE94_00570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IQE94_00580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IQE94_00640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IQE94_00660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IQE94_00665	COG4208	sulfate ABC transporter
IQE94_00670	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IQE94_00675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IQE94_00680	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IQE94_00695	COG0483	inositol monophosphate 1-phosphatase activity
IQE94_00700	COG0745	RESPONSE REGULATOR receiver
IQE94_00720	COG4279	zinc finger
IQE94_00735	COG1834	amidinotransferase
IQE94_00745	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IQE94_00755	COG2193	ferroxidase activity
IQE94_00765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IQE94_00770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IQE94_00775	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IQE94_00855	COG0156	8-amino-7-oxononanoate synthase activity
IQE94_00860	COG0024	Methionine aminopeptidase
IQE94_00885	COG1178	ABC-type Fe3 transport system permease component
IQE94_00890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IQE94_00915	COG2197	response regulator
IQE94_00920	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_00930	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_00945	COG0237	dephospho-CoA kinase activity
IQE94_00945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IQE94_00980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IQE94_01005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IQE94_01015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IQE94_01035	COG1446	asparaginase
IQE94_01040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IQE94_01045	COG0832	Belongs to the urease beta subunit family
IQE94_01050	COG2226	methyltransferase
IQE94_01085	COG0025	NhaP-type Na H and K H
IQE94_01095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IQE94_01120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IQE94_01140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IQE94_01180	COG3239	Fatty acid desaturase
IQE94_01190	COG1950	PFAM Membrane protein of
IQE94_01205	COG1253	flavin adenine dinucleotide binding
IQE94_01210	COG0228	four-way junction DNA binding
IQE94_01225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IQE94_01230	COG2010	Cytochrome c
IQE94_01245	COG0802	atpase or kinase
IQE94_01250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IQE94_01250	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IQE94_01255	COG0497	DNA recombination
IQE94_01285	COG1429	ligase activity, forming nitrogen-metal bonds
IQE94_01305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IQE94_01320	COG0133	tryptophan synthase activity
IQE94_01325	COG0740	serine-type endopeptidase activity
IQE94_01330	COG0519	Catalyzes the synthesis of GMP from XMP
IQE94_01330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IQE94_01335	COG0463	Glycosyl transferase, family 2
IQE94_01340	COG0018	arginyl-trna synthetase
IQE94_01345	COG1160	GTP binding
IQE94_01350	COG0019	diaminopimelate decarboxylase activity
IQE94_01360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IQE94_01365	COG0598	Magnesium transport protein CorA
IQE94_01395	COG0717	Belongs to the dCTP deaminase family
IQE94_01400	COG0387	Pfam Sodium calcium exchanger
IQE94_01410	COG0052	Belongs to the universal ribosomal protein uS2 family
IQE94_01420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IQE94_01430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IQE94_01445	COG1160	GTP binding
IQE94_01455	COG0457	Tetratricopeptide repeat
IQE94_01460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IQE94_01465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IQE94_01470	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IQE94_01515	COG2165	general secretion pathway protein
IQE94_01520	COG4968	Prepilin-type N-terminal cleavage methylation domain
IQE94_01530	COG4106	trans-aconitate 2-methyltransferase activity
IQE94_01535	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_01540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IQE94_01545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IQE94_01560	COG2199	diguanylate cyclase activity
IQE94_01565	COG0750	zinc metalloprotease
IQE94_01570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IQE94_01580	COG0590	tRNA wobble adenosine to inosine editing
IQE94_01590	COG0415	Belongs to the DNA photolyase family
IQE94_01605	COG3409	Peptidoglycan-binding domain 1 protein
IQE94_01605	COG3429	Glucose-6-phosphate dehydrogenase subunit
IQE94_01615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IQE94_01650	COG0745	RESPONSE REGULATOR receiver
IQE94_01655	COG5002	protein histidine kinase activity
IQE94_01700	COG1122	ATPase activity
IQE94_01705	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IQE94_01725	COG0070	glutamate synthase
IQE94_01725	COG0069	glutamate synthase activity
IQE94_01725	COG0067	glutamate synthase
IQE94_01735	COG0047	phosphoribosylformylglycinamidine synthase activity
IQE94_01740	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IQE94_01745	COG0456	acetyltransferase
IQE94_01760	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_01770	COG1840	ABC-type Fe3 transport system, periplasmic component
IQE94_01775	COG0811	peptide transport
IQE94_01790	COG0251	oxidation-reduction process
IQE94_01795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IQE94_01800	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IQE94_01805	COG0392	lysyltransferase activity
IQE94_01830	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IQE94_01840	COG0343	queuine tRNA-ribosyltransferase activity
IQE94_01860	COG2886	Uncharacterised protein family (UPF0175)
IQE94_01865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IQE94_01870	COG0668	transmembrane transport
IQE94_01875	COG0205	6-phosphofructokinase activity
IQE94_01890	COG0674	pyruvate-flavodoxin oxidoreductase activity
IQE94_01890	COG1013	pyruvate-flavodoxin oxidoreductase activity
IQE94_01890	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IQE94_01890	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IQE94_01900	COG3842	ATPase activity
IQE94_01905	COG0725	ABC transporter, periplasmic molybdate-binding protein
IQE94_01930	COG0438	transferase activity, transferring glycosyl groups
IQE94_01945	COG0643	Histidine kinase
IQE94_01945	COG0784	Response regulator, receiver
IQE94_01945	COG2198	Histidine kinase
IQE94_01955	COG0840	transmembrane signaling receptor activity
IQE94_01955	COG2203	Gaf domain
IQE94_01970	COG0784	Response regulator, receiver
IQE94_01980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IQE94_01985	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IQE94_01990	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
IQE94_01995	COG1597	lipid kinase activity
IQE94_01995	COG1803	Methylglyoxal synthase
IQE94_02000	COG0436	Aminotransferase
IQE94_02085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IQE94_02130	COG0857	belongs to the CobB CobQ family
IQE94_02135	COG0583	DNA-binding transcription factor activity
IQE94_02140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IQE94_02145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IQE94_02150	COG3659	wide pore channel activity
IQE94_02155	COG1116	anion transmembrane transporter activity
IQE94_02155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IQE94_02160	COG1116	anion transmembrane transporter activity
IQE94_02220	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IQE94_02225	COG0571	ribonuclease III activity
IQE94_02245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IQE94_02250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IQE94_02265	COG0628	permease
IQE94_02270	COG0149	triose-phosphate isomerase activity
IQE94_02280	COG2205	protein histidine kinase activity
IQE94_02285	COG1231	oxidoreductase activity
IQE94_02295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IQE94_02305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IQE94_02310	COG0450	alkyl hydroperoxide reductase
IQE94_02320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IQE94_02330	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IQE94_02340	COG1131	(ABC) transporter
IQE94_02370	COG0439	Biotin carboxylase
IQE94_02390	COG0590	tRNA wobble adenosine to inosine editing
IQE94_02395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IQE94_02405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IQE94_02415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IQE94_02430	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IQE94_02435	COG4251	negative regulation of phosphorylation
IQE94_02440	COG0784	Response regulator, receiver
IQE94_02445	COG1032	radical SAM domain protein
IQE94_02450	COG0167	dihydroorotate dehydrogenase activity
IQE94_02455	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IQE94_02460	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_02465	COG0839	Belongs to the complex I subunit 6 family
IQE94_02470	COG0713	ATP synthesis coupled electron transport
IQE94_02480	COG0525	valine-tRNA ligase activity
IQE94_02495	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IQE94_02500	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IQE94_02525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IQE94_02530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IQE94_02535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IQE94_02545	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IQE94_02550	COG5001	Diguanylate cyclase
IQE94_02550	COG1716	ATPase activity
IQE94_02555	COG3631	Ketosteroid isomerase-related protein
IQE94_02565	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IQE94_02565	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IQE94_02575	COG0107	imidazoleglycerol-phosphate synthase activity
IQE94_02580	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IQE94_02585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IQE94_02590	COG0438	transferase activity, transferring glycosyl groups
IQE94_02645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IQE94_02650	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IQE94_02660	COG0514	ATP-dependent DNA helicase (RecQ)
IQE94_02675	COG0776	regulation of translation
IQE94_02690	COG0668	transmembrane transport
IQE94_02695	COG0668	transmembrane transport
IQE94_02715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IQE94_02715	COG1754	DNA topoisomerase type I activity
IQE94_02720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IQE94_02725	COG0640	Transcriptional regulator
IQE94_02730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IQE94_02745	COG2188	Transcriptional regulator
IQE94_02765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IQE94_02775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IQE94_02785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IQE94_02795	COG0831	urea catabolic process
IQE94_02800	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IQE94_02805	COG1562	ergosterol biosynthetic process
IQE94_02810	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IQE94_02810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IQE94_02840	COG2154	pterin-4-alpha-carbinolamine dehydratase
IQE94_02845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IQE94_02855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IQE94_02870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IQE94_02875	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IQE94_02880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IQE94_02940	COG1187	pseudouridine synthase activity
IQE94_02945	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IQE94_02975	COG1012	belongs to the aldehyde dehydrogenase family
IQE94_02980	COG3384	dioxygenase
IQE94_02995	COG3659	wide pore channel activity
IQE94_03000	COG0745	RESPONSE REGULATOR receiver
IQE94_03005	COG0860	N-Acetylmuramoyl-L-alanine amidase
IQE94_03005	COG2247	cell wall binding repeat
IQE94_03075	COG0768	penicillin binding
IQE94_03085	COG0247	lactate metabolic process
IQE94_03095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IQE94_03100	COG0583	DNA-binding transcription factor activity
IQE94_03110	COG0384	phenazine biosynthesis protein PhzF
IQE94_03120	COG0606	chelatase, subunit chli
IQE94_03130	COG0314	molybdopterin synthase activity
IQE94_03140	COG0315	cyclic pyranopterin monophosphate synthase activity
IQE94_03140	COG0746	molybdenum cofactor guanylyltransferase activity
IQE94_03145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IQE94_03150	COG0303	'Molybdopterin
IQE94_03155	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
IQE94_03165	COG1480	7TM receptor with intracellular HD hydrolase
IQE94_03175	COG0800	Aldolase
IQE94_03180	COG0004	ammonium transporteR
IQE94_03185	COG5001	Diguanylate cyclase
IQE94_03185	COG3300	MHYT domain
IQE94_03210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IQE94_03225	COG0628	permease
IQE94_03240	COG0066	3-isopropylmalate dehydratase activity
IQE94_03245	COG0504	CTP synthase activity
IQE94_03260	COG2204	response regulator
IQE94_03270	COG0259	pyridoxamine-phosphate oxidase activity
IQE94_03285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IQE94_03305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IQE94_03310	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IQE94_03320	COG0300	oxidoreductase activity
IQE94_03340	COG0798	PFAM Bile acid sodium symporter
IQE94_03345	COG0431	NADPH-dependent FMN reductase
IQE94_03350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IQE94_03410	COG1657	PFAM Prenyltransferase squalene oxidase
IQE94_03425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IQE94_03430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IQE94_03460	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IQE94_03485	COG4581	dead DEAH box helicase
IQE94_03515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IQE94_03530	COG0386	Belongs to the glutathione peroxidase family
IQE94_03535	COG2119	membrane
IQE94_03545	COG0371	Dehydrogenase
IQE94_03550	COG0644	oxidoreductase
IQE94_03575	COG2267	carboxylic ester hydrolase activity
IQE94_03585	COG3842	ATPase activity
IQE94_03590	COG1090	epimerase
IQE94_03615	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IQE94_03625	COG0275	rRNA processing
IQE94_03635	COG0793	Belongs to the peptidase S41A family
IQE94_03645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IQE94_03650	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IQE94_03660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IQE94_03665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IQE94_03670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IQE94_03675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IQE94_03675	COG1116	anion transmembrane transporter activity
IQE94_03680	COG1116	anion transmembrane transporter activity
IQE94_03690	COG0243	molybdopterin cofactor binding
IQE94_03715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IQE94_03725	COG0242	peptide deformylase activity
IQE94_03730	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IQE94_03745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IQE94_03750	COG1131	(ABC) transporter
IQE94_03760	COG0830	nickel cation binding
IQE94_03765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IQE94_03775	COG2010	Cytochrome c
IQE94_03795	COG0783	Belongs to the Dps family
IQE94_03800	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IQE94_03805	COG0088	Forms part of the polypeptide exit tunnel
IQE94_03810	COG0089	rRNA binding
IQE94_03815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IQE94_03820	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IQE94_03825	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IQE94_03830	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IQE94_03835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IQE94_03840	COG0255	Belongs to the universal ribosomal protein uL29 family
IQE94_03845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IQE94_03850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IQE94_03855	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IQE94_03860	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IQE94_03865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IQE94_03870	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IQE94_03875	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IQE94_03880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IQE94_03885	COG0200	Binds to the 23S rRNA
IQE94_03890	COG0201	protein transport
IQE94_03895	COG0563	adenylate kinase activity
IQE94_03900	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IQE94_03905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IQE94_03910	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IQE94_03915	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IQE94_03920	COG0202	RNA polymerase activity
IQE94_03925	COG0203	ribosomal protein L17
IQE94_03930	COG0101	tRNA pseudouridine synthase activity
IQE94_03935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IQE94_03940	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IQE94_03945	COG0254	rRNA binding
IQE94_03960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IQE94_03965	COG5002	protein histidine kinase activity
IQE94_03970	COG1192	Involved in chromosome partitioning
IQE94_03985	COG0745	RESPONSE REGULATOR receiver
IQE94_04000	COG1612	heme a metabolic process
IQE94_04005	COG0109	protoheme IX farnesyltransferase activity
IQE94_04010	COG0298	carbon dioxide binding
IQE94_04035	COG1032	radical SAM domain protein
IQE94_04045	COG0359	binds to the 23S rRNA
IQE94_04050	COG2010	Cytochrome c
IQE94_04055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IQE94_04060	COG1672	PFAM Archaeal ATPase
IQE94_04065	COG3239	Fatty acid desaturase
IQE94_04070	COG0166	Belongs to the GPI family
IQE94_04075	COG1045	serine acetyltransferase
IQE94_04080	COG0288	reversible hydration of carbon dioxide
IQE94_04085	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IQE94_04085	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IQE94_04125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IQE94_04135	COG1473	amidohydrolase
IQE94_04155	COG2304	oxidoreductase activity
IQE94_04165	COG2211	Major facilitator Superfamily
IQE94_04180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IQE94_04185	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_04190	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_04195	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_04200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IQE94_04205	COG0037	tRNA processing
IQE94_04245	COG3659	wide pore channel activity
IQE94_04260	COG0405	Gamma-glutamyltransferase
IQE94_04265	COG0772	Belongs to the SEDS family
IQE94_04275	COG2192	nodulation
IQE94_04280	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IQE94_04285	COG2274	protein secretion by the type I secretion system
IQE94_04290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IQE94_04295	COG0723	plastoquinol--plastocyanin reductase activity
IQE94_04310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IQE94_04350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IQE94_04360	COG0784	Response regulator, receiver
IQE94_04365	COG0745	RESPONSE REGULATOR receiver
IQE94_04370	COG3706	GGDEF domain
IQE94_04370	COG2203	Gaf domain
IQE94_04370	COG4251	negative regulation of phosphorylation
IQE94_04370	COG5001	Diguanylate cyclase
IQE94_04390	COG1028	Short-chain dehydrogenase reductase Sdr
IQE94_04390	COG3347	Dehydrogenase
IQE94_04425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IQE94_04435	COG1175	transmembrane transport
IQE94_04450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IQE94_04455	COG0450	alkyl hydroperoxide reductase
IQE94_04470	COG0393	Putative heavy-metal-binding
IQE94_04475	COG0758	DNA mediated transformation
IQE94_04475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IQE94_04495	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IQE94_04505	COG1196	nuclear chromosome segregation
IQE94_04510	COG0113	porphobilinogen synthase activity
IQE94_04515	COG0803	Belongs to the bacterial solute-binding protein 9 family
IQE94_04520	COG1121	(ABC) transporter
IQE94_04525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IQE94_04530	COG0523	cobalamin synthesis protein
IQE94_04535	COG0302	gtp cyclohydrolase
IQE94_04555	COG0210	DNA helicase
IQE94_04565	COG5002	protein histidine kinase activity
IQE94_04570	COG0268	Binds directly to 16S ribosomal RNA
IQE94_04575	COG0084	hydrolase, TatD family'
IQE94_04580	COG0085	RNA polymerase activity
IQE94_04585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IQE94_04625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IQE94_04640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IQE94_04650	COG0741	lytic transglycosylase activity
IQE94_04655	COG2205	protein histidine kinase activity
IQE94_04665	COG0395	ABC-type sugar transport system, permease component
IQE94_04670	COG1175	transmembrane transport
IQE94_04675	COG1653	transport
IQE94_04680	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IQE94_04685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IQE94_04695	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IQE94_04700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IQE94_04705	COG0724	RNA recognition motif
IQE94_04715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IQE94_04720	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_04735	COG0151	Belongs to the GarS family
IQE94_04745	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IQE94_04750	COG0049	tRNA binding
IQE94_04755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IQE94_04760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IQE94_04765	COG0051	transcription antitermination factor activity, RNA binding
IQE94_04785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IQE94_04800	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_04805	COG1619	proteins homologs of microcin C7 resistance protein MccF
IQE94_04815	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IQE94_04830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IQE94_04850	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IQE94_04855	COG0222	ribosome binding
IQE94_04860	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IQE94_04865	COG0081	regulation of translation
IQE94_04870	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IQE94_04875	COG0250	Participates in transcription elongation, termination and antitermination
IQE94_04880	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IQE94_04890	COG0335	large ribosomal subunit rRNA binding
IQE94_04920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IQE94_04930	COG3243	poly(R)-hydroxyalkanoic acid synthase
IQE94_04940	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IQE94_04950	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_04955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IQE94_04965	COG2885	chlorophyll binding
IQE94_04970	COG2885	chlorophyll binding
IQE94_04995	COG0508	dehydrogenase complex catalyzes the overall conversion of
IQE94_04995	COG0022	dehydrogenase e1 component
IQE94_05000	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IQE94_05005	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IQE94_05010	COG1929	Belongs to the glycerate kinase type-1 family
IQE94_05015	COG3659	wide pore channel activity
IQE94_05025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IQE94_05045	COG0495	leucyl-tRNA aminoacylation
IQE94_05050	COG0786	glutamate:sodium symporter activity
IQE94_05080	COG1606	tRNA processing
IQE94_05090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IQE94_05095	COG2045	Belongs to the ComB family
IQE94_05100	COG0778	Nitroreductase
IQE94_05105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IQE94_05115	COG0516	GMP reductase activity
IQE94_05120	COG0395	ABC-type sugar transport system, permease component
IQE94_05145	COG0189	ligase activity
IQE94_05145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IQE94_05150	COG4242	Belongs to the peptidase S51 family
IQE94_05175	COG1028	Short-chain dehydrogenase reductase Sdr
IQE94_05180	COG0183	Belongs to the thiolase family
IQE94_05185	COG0386	Belongs to the glutathione peroxidase family
IQE94_05200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IQE94_05205	COG2264	protein methyltransferase activity
IQE94_05245	COG0438	transferase activity, transferring glycosyl groups
IQE94_05250	COG0488	(ABC) transporter
IQE94_05260	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IQE94_05280	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IQE94_05285	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IQE94_05290	COG0561	phosphatase activity
IQE94_05295	COG1366	Belongs to the anti-sigma-factor antagonist family
IQE94_05300	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IQE94_05305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IQE94_05315	COG0215	cysteine-tRNA ligase activity
IQE94_05320	COG0424	maF-like protein
IQE94_05335	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
IQE94_05360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IQE94_05365	COG1799	cell septum assembly
IQE94_05370	COG0662	Cupin 2, conserved barrel domain protein
IQE94_05370	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IQE94_05380	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IQE94_05385	COG0459	protein refolding
IQE94_05395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IQE94_05405	COG2140	Oxalate decarboxylase
IQE94_05410	COG0058	SHG alpha-glucan phosphorylase activity
IQE94_05415	COG4658	electron transport chain
IQE94_05420	COG0515	serine threonine protein kinase
IQE94_05535	COG1372	Participates in initiation and elongation during chromosome replication
IQE94_05535	COG0305	Participates in initiation and elongation during chromosome replication
IQE94_05600	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IQE94_05600	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IQE94_05605	COG3437	response regulator, receiver
IQE94_05605	COG3850	Histidine kinase
IQE94_05605	COG2205	protein histidine kinase activity
IQE94_05605	COG4999	Histidine kinase
IQE94_05635	COG0546	phosphoglycolate phosphatase activity
IQE94_05640	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IQE94_05645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IQE94_05660	COG0501	Belongs to the peptidase M48B family
IQE94_05665	COG0539	negative regulation of cytoplasmic translation
IQE94_05670	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IQE94_05675	COG1132	(ABC) transporter
IQE94_05680	COG0469	pyruvate kinase activity
IQE94_05700	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IQE94_05705	COG1268	BioY protein
IQE94_05710	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IQE94_05730	COG1104	cysteine desulfurase activity
IQE94_05740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IQE94_05745	COG1061	Type III restriction enzyme res subunit
IQE94_05755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IQE94_05755	COG0519	Catalyzes the synthesis of GMP from XMP
IQE94_05775	COG1492	cobalamin metabolic process
IQE94_05780	COG0025	NhaP-type Na H and K H
IQE94_05785	COG0583	DNA-binding transcription factor activity
IQE94_05820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IQE94_05830	COG5398	heme oxygenase
IQE94_05835	COG0408	coproporphyrinogen oxidase activity
IQE94_05845	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IQE94_05875	COG0277	FAD linked oxidase domain protein
IQE94_05905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IQE94_05910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IQE94_05920	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IQE94_05935	COG1555	photosystem II stabilization
IQE94_05940	COG1289	transmembrane transporter activity
IQE94_05945	COG0205	6-phosphofructokinase activity
IQE94_05955	COG0336	Belongs to the RNA methyltransferase TrmD family
IQE94_05960	COG1840	ABC-type Fe3 transport system, periplasmic component
IQE94_05980	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_06005	COG4636	protein conserved in cyanobacteria
IQE94_06010	COG0538	isocitrate dehydrogenase activity
IQE94_06020	COG2226	methyltransferase
IQE94_06025	COG0589	response to stress
IQE94_06055	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IQE94_06080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IQE94_06165	COG0375	protein maturation
IQE94_06180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IQE94_06185	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IQE94_06190	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IQE94_06200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IQE94_06210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IQE94_06230	COG0312	modulator of DNA gyrase
IQE94_06240	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IQE94_06260	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IQE94_06280	COG0189	ligase activity
IQE94_06285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IQE94_06295	COG2267	carboxylic ester hydrolase activity
IQE94_06310	COG0402	S-adenosylhomocysteine deaminase activity
IQE94_06340	COG0537	adenosine 5'-monophosphoramidase activity
IQE94_06365	COG1233	COG1233 Phytoene dehydrogenase and related
IQE94_06370	COG0589	response to stress
IQE94_06375	COG0659	secondary active sulfate transmembrane transporter activity
IQE94_06380	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IQE94_06385	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IQE94_06390	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IQE94_06400	COG0515	serine threonine protein kinase
IQE94_06410	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IQE94_06440	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
IQE94_06450	COG0747	negative chemotaxis
IQE94_06460	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IQE94_06465	COG0596	Alpha beta hydrolase
IQE94_06475	COG0616	signal peptide processing
IQE94_06485	COG2203	Gaf domain
IQE94_06485	COG3706	GGDEF domain
IQE94_06485	COG4251	negative regulation of phosphorylation
IQE94_06485	COG5001	Diguanylate cyclase
IQE94_06490	COG2197	response regulator
IQE94_06520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IQE94_06545	COG2886	Uncharacterised protein family (UPF0175)
IQE94_06565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IQE94_06580	COG0443	Heat shock 70 kDa protein
IQE94_06590	COG0646	methionine synthase
IQE94_06590	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IQE94_06610	COG0187	DNA topoisomerase II activity
IQE94_06610	COG1372	Participates in initiation and elongation during chromosome replication
IQE94_06625	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IQE94_06635	COG0612	Peptidase, M16
IQE94_06640	COG0612	Peptidase, M16
IQE94_06645	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IQE94_06650	COG0602	queuosine metabolic process
IQE94_06655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IQE94_06665	COG1489	DNA binding
IQE94_06675	COG0280	phosphate acetyltransferase
IQE94_06675	COG0857	belongs to the CobB CobQ family
IQE94_06680	COG0427	acetyl-CoA hydrolase
IQE94_06685	COG0181	hydroxymethylbilane synthase activity
IQE94_06695	COG0799	negative regulation of ribosome biogenesis
IQE94_06710	COG0180	Tryptophanyl-tRNA synthetase
IQE94_06730	COG0196	riboflavin kinase activity
IQE94_06740	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_06745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IQE94_06755	COG0083	homoserine kinase activity
IQE94_06790	COG0641	radical SAM
IQE94_06795	COG1413	lyase activity
IQE94_06800	COG0179	Fumarylacetoacetate (FAA) hydrolase
IQE94_06805	COG0360	Binds together with S18 to 16S ribosomal RNA
IQE94_06815	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IQE94_06820	COG3932	Exopolysaccharide synthesis, ExoD
IQE94_06825	COG1181	Belongs to the D-alanine--D-alanine ligase family
IQE94_06845	COG3937	granule-associated protein
IQE94_06860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IQE94_06865	COG0631	protein serine/threonine phosphatase activity
IQE94_06870	COG1193	negative regulation of DNA recombination
IQE94_06880	COG1741	Belongs to the pirin family
IQE94_06915	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IQE94_06920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IQE94_06955	COG2208	phosphoserine phosphatase activity
IQE94_06955	COG2770	Histidine kinase
IQE94_06970	COG1366	Belongs to the anti-sigma-factor antagonist family
IQE94_06995	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IQE94_07010	COG1082	Xylose isomerase domain protein TIM barrel
IQE94_07030	COG2319	Wd-40 repeat
IQE94_07035	COG2319	Wd-40 repeat
IQE94_07050	COG1028	Short-chain dehydrogenase reductase Sdr
IQE94_07055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IQE94_07080	COG0723	plastoquinol--plastocyanin reductase activity
IQE94_07085	COG3258	Cytochrome c
IQE94_07095	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IQE94_07120	COG0322	excinuclease ABC activity
IQE94_07130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IQE94_07145	COG1028	Short-chain dehydrogenase reductase Sdr
IQE94_07150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IQE94_07225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IQE94_07230	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IQE94_07240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IQE94_07275	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IQE94_07300	COG0509	glycine decarboxylation via glycine cleavage system
IQE94_07305	COG0739	heme binding
IQE94_07310	COG0154	amidase activity
IQE94_07315	COG0724	RNA recognition motif
IQE94_07330	COG0632	four-way junction helicase activity
IQE94_07335	COG1970	mechanosensitive ion channel activity
IQE94_07355	COG0575	Belongs to the CDS family
IQE94_07365	COG0058	SHG alpha-glucan phosphorylase activity
IQE94_07375	COG0765	amino acid transport
IQE94_07380	COG3659	wide pore channel activity
IQE94_07385	COG5001	Diguanylate cyclase
IQE94_07385	COG3300	MHYT domain
IQE94_07405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IQE94_07410	COG0443	Heat shock 70 kDa protein
IQE94_07415	COG0484	heat shock protein binding
IQE94_07435	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IQE94_07450	COG1702	phosphate starvation-inducible protein PhoH
IQE94_07465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IQE94_07470	COG1121	(ABC) transporter
IQE94_07505	COG3228	Belongs to the MtfA family
IQE94_07510	COG0784	Response regulator, receiver
IQE94_07515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IQE94_07550	COG2319	Wd-40 repeat
IQE94_07555	COG1587	Uroporphyrinogen-III synthase
IQE94_07575	COG0443	Heat shock 70 kDa protein
IQE94_07580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IQE94_07585	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IQE94_07595	COG1937	Protein conserved in bacteria
IQE94_07605	COG0516	GMP reductase activity
IQE94_07605	COG0517	IMP dehydrogenase activity
IQE94_07620	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IQE94_07655	COG2202	Pas domain
IQE94_07655	COG2205	protein histidine kinase activity
IQE94_07670	COG4783	chaperone-mediated protein folding
IQE94_07675	COG2205	protein histidine kinase activity
IQE94_07675	COG3437	response regulator, receiver
IQE94_07675	COG3850	Histidine kinase
IQE94_07675	COG4999	Histidine kinase
IQE94_07685	COG4956	integral membrane protein (PIN domain superfamily)
IQE94_07700	COG1160	GTP binding
IQE94_07710	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IQE94_07725	COG0432	Pfam Uncharacterised protein family UPF0047
IQE94_07730	COG2197	response regulator
IQE94_07745	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IQE94_07750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IQE94_07760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IQE94_07765	COG5398	heme oxygenase
IQE94_07770	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
IQE94_07780	COG1316	TRANSCRIPTIONal
IQE94_07795	COG2208	phosphoserine phosphatase activity
IQE94_07795	COG2770	Histidine kinase
IQE94_07800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IQE94_07810	COG0539	negative regulation of cytoplasmic translation
IQE94_07815	COG0358	DNA primase activity
IQE94_07825	COG0009	L-threonylcarbamoyladenylate synthase
IQE94_07845	COG0589	response to stress
IQE94_07860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IQE94_07880	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IQE94_07885	COG0594	ribonuclease P activity
IQE94_07895	COG0706	membrane insertase activity
IQE94_07905	COG0484	heat shock protein binding
IQE94_07910	COG0483	inositol monophosphate 1-phosphatase activity
IQE94_07915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IQE94_07930	COG0791	NLP P60 protein
IQE94_07950	COG0540	Belongs to the ATCase OTCase family
IQE94_07980	COG1215	transferase activity, transferring glycosyl groups
IQE94_08000	COG0300	oxidoreductase activity
IQE94_08000	COG3000	fatty acid hydroxylase
IQE94_08020	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IQE94_08025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IQE94_08030	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IQE94_08035	COG0463	Glycosyl transferase, family 2
IQE94_08040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IQE94_08055	COG1472	Belongs to the glycosyl hydrolase 3 family
IQE94_08065	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IQE94_08070	COG1280	lysine exporter protein (LysE YggA)
IQE94_08085	COG0564	pseudouridine synthase activity
IQE94_08095	COG0438	transferase activity, transferring glycosyl groups
IQE94_08135	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IQE94_08160	COG0500	methyltransferase
IQE94_08165	COG0542	response to heat
IQE94_08175	COG0572	uridine kinase
IQE94_08190	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IQE94_08195	COG0561	phosphatase activity
IQE94_08210	COG0571	ribonuclease III activity
IQE94_08215	COG0390	transport system, permease component
IQE94_08220	COG0668	transmembrane transport
IQE94_08225	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
IQE94_08235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IQE94_08240	COG0426	domain, Protein
IQE94_08240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IQE94_08250	COG0126	phosphoglycerate kinase activity
IQE94_08255	COG0583	DNA-binding transcription factor activity
IQE94_08260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IQE94_08300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IQE94_08315	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IQE94_08320	COG0347	Belongs to the P(II) protein family
IQE94_08335	COG0135	phosphoribosylanthranilate isomerase activity
IQE94_08340	COG0697	spore germination
IQE94_08350	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IQE94_08365	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IQE94_08370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IQE94_08380	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IQE94_08415	COG0310	cobalt ion transport
IQE94_08425	COG1122	ATPase activity
IQE94_08435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IQE94_08445	COG0475	glutathione-regulated potassium exporter activity
IQE94_08445	COG0589	response to stress
IQE94_08455	COG0406	alpha-ribazole phosphatase activity
IQE94_08460	COG0745	RESPONSE REGULATOR receiver
IQE94_08470	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IQE94_08480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IQE94_08510	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IQE94_08515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IQE94_08530	COG2211	Major facilitator Superfamily
IQE94_08550	COG5002	protein histidine kinase activity
IQE94_08555	COG0668	transmembrane transport
IQE94_08560	COG0752	glycyl-tRNA synthetase alpha subunit
IQE94_08575	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IQE94_08585	COG0354	folic acid binding
IQE94_08590	COG0583	DNA-binding transcription factor activity
IQE94_08620	COG0697	spore germination
IQE94_08650	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IQE94_08660	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IQE94_08665	COG3339	Conserved Protein
IQE94_08675	COG0312	modulator of DNA gyrase
IQE94_08680	COG0482	sulfurtransferase activity
IQE94_08695	COG0488	(ABC) transporter
IQE94_08710	COG0284	orotidine-5'-phosphate decarboxylase activity
IQE94_08760	COG1132	(ABC) transporter
IQE94_08770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IQE94_08775	COG2084	Dehydrogenase
IQE94_08785	COG0805	protein transport
IQE94_08790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IQE94_08795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IQE94_08805	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IQE94_08815	COG0445	tRNA wobble uridine modification
IQE94_08825	COG3794	PFAM blue (type 1) copper domain protein
IQE94_08835	COG1234	tRNA 3'-trailer cleavage
IQE94_08870	COG0010	Belongs to the arginase family
IQE94_08875	COG0375	protein maturation
IQE94_08890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IQE94_08895	COG1116	anion transmembrane transporter activity
IQE94_08900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IQE94_08905	COG3118	belongs to the thioredoxin family
IQE94_08910	COG1845	cytochrome c oxidase, subunit III
IQE94_08915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IQE94_08920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IQE94_08940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IQE94_08945	COG0517	IMP dehydrogenase activity
IQE94_08945	COG1994	Peptidase M50
IQE94_08955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IQE94_08955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IQE94_08980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IQE94_09000	COG2046	Belongs to the sulfate adenylyltransferase family
IQE94_09005	COG0438	transferase activity, transferring glycosyl groups
IQE94_09015	COG0737	Belongs to the 5'-nucleotidase family
IQE94_09030	COG2361	Protein of unknown function DUF86
IQE94_09040	COG2361	Protein of unknown function DUF86
IQE94_09065	COG1487	ribonuclease activity
IQE94_09075	COG4115	mRNA cleavage
IQE94_09110	COG0067	glutamate synthase
IQE94_09110	COG0069	glutamate synthase activity
IQE94_09110	COG0070	glutamate synthase
IQE94_09120	COG0515	serine threonine protein kinase
IQE94_09135	COG2133	pyrroloquinoline quinone binding
IQE94_09140	COG1797	cobyrinic acid a,c-diamide synthase activity
IQE94_09145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IQE94_09150	COG1022	Amp-dependent synthetase and ligase
IQE94_09155	COG0784	Response regulator, receiver
IQE94_09170	COG0840	transmembrane signaling receptor activity
IQE94_09170	COG2203	Gaf domain
IQE94_09175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IQE94_09180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IQE94_09185	COG2203	Gaf domain
IQE94_09185	COG3706	GGDEF domain
IQE94_09185	COG4251	negative regulation of phosphorylation
IQE94_09185	COG5001	Diguanylate cyclase
IQE94_09195	COG0419	ATPase involved in DNA repair
IQE94_09200	COG0484	heat shock protein binding
IQE94_09205	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IQE94_09215	COG2314	TM2 domain
IQE94_09240	COG0017	Asparaginyl-tRNA synthetase
IQE94_09260	COG0569	domain protein
IQE94_09265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IQE94_09270	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IQE94_09275	COG0629	single-stranded DNA binding
IQE94_09285	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IQE94_09295	COG1192	Involved in chromosome partitioning
IQE94_09305	COG2119	membrane
IQE94_09310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IQE94_09315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IQE94_09325	COG1162	GTPase activity
IQE94_09335	COG0484	heat shock protein binding
IQE94_09340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IQE94_09345	COG1218	3'(2'),5'-bisphosphate nucleotidase
IQE94_09350	COG0134	indole-3-glycerol-phosphate synthase activity
IQE94_09355	COG0004	ammonium transporteR
IQE94_09360	COG0569	domain protein
IQE94_09375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IQE94_09380	COG0740	serine-type endopeptidase activity
IQE94_09385	COG0544	peptidyl-prolyl cis-trans isomerase activity
IQE94_09390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IQE94_09395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IQE94_09400	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IQE94_09410	COG0237	dephospho-CoA kinase activity
IQE94_09425	COG1234	tRNA 3'-trailer cleavage
IQE94_09435	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IQE94_09450	COG0631	protein serine/threonine phosphatase activity
IQE94_09455	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IQE94_09465	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
IQE94_09470	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IQE94_09475	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IQE94_09480	COG0493	'glutamate synthase
IQE94_09485	COG3659	wide pore channel activity
IQE94_09510	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
IQE94_09510	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
IQE94_09540	COG1982	Orn Lys Arg decarboxylase major
IQE94_09550	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IQE94_09570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IQE94_09575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IQE94_09580	COG0745	RESPONSE REGULATOR receiver
IQE94_09585	COG0673	inositol 2-dehydrogenase activity
IQE94_09590	COG0700	Nucleoside recognition
IQE94_09595	COG2715	membrane protein required for spore maturation
IQE94_09600	COG1640	4-alpha-glucanotransferase
IQE94_09610	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IQE94_09615	COG2203	Gaf domain
IQE94_09615	COG3706	GGDEF domain
IQE94_09615	COG5001	Diguanylate cyclase
IQE94_09615	COG4251	negative regulation of phosphorylation
IQE94_09620	COG2205	protein histidine kinase activity
IQE94_09620	COG0784	Response regulator, receiver
IQE94_09635	COG1981	membrane
IQE94_09640	COG0175	sulfate reduction
IQE94_09645	COG1420	regulation of RNA biosynthetic process
IQE94_09655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IQE94_09660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IQE94_09670	COG0003	Pfam Anion-transporting ATPase
IQE94_09675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IQE94_09690	COG0484	heat shock protein binding
IQE94_09695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IQE94_09715	COG0077	Prephenate dehydratase
IQE94_09715	COG1605	Chorismate mutase
IQE94_09725	COG5001	Diguanylate cyclase
IQE94_09725	COG4251	negative regulation of phosphorylation
IQE94_09725	COG2203	Gaf domain
IQE94_09725	COG3706	GGDEF domain
IQE94_09745	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IQE94_09750	COG1595	DNA-templated transcription, initiation
IQE94_09765	COG0415	Belongs to the DNA photolyase family
IQE94_09790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IQE94_09800	COG1252	NADH dehydrogenase
IQE94_09840	COG0678	peroxiredoxin activity
IQE94_09870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IQE94_09890	COG2205	protein histidine kinase activity
IQE94_09895	COG2890	protein-(glutamine-N5) methyltransferase activity
IQE94_09900	COG0312	modulator of DNA gyrase
IQE94_09920	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IQE94_09930	COG0113	porphobilinogen synthase activity
IQE94_09970	COG0463	Glycosyl transferase, family 2
IQE94_09985	COG1442	glycosyl transferase family 8
IQE94_10000	COG0500	methyltransferase
IQE94_10025	COG3385	transposase activity
IQE94_10035	COG2226	methyltransferase
IQE94_10045	COG4115	mRNA cleavage
IQE94_10050	COG2161	toxin-antitoxin pair type II binding
IQE94_10075	COG0629	single-stranded DNA binding
IQE94_10080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IQE94_10085	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
IQE94_10095	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IQE94_10120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IQE94_10160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IQE94_10170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IQE94_10180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IQE94_10200	COG0095	Lipoate-protein ligase
IQE94_10205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IQE94_10210	COG0656	L-ascorbic acid biosynthetic process
IQE94_10220	COG1575	Belongs to the MenA family. Type 1 subfamily
IQE94_10230	COG0473	3-isopropylmalate dehydrogenase activity
IQE94_10235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IQE94_10240	COG3063	Type IV pilus biogenesis stability protein PilW
IQE94_10260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IQE94_10265	COG0347	Belongs to the P(II) protein family
IQE94_10280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IQE94_10285	COG0416	fatty acid biosynthetic process
IQE94_10295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IQE94_10300	COG0438	transferase activity, transferring glycosyl groups
IQE94_10330	COG0454	-acetyltransferase
IQE94_10345	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IQE94_10360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IQE94_10365	COG1247	-acetyltransferase
IQE94_10370	COG0174	glutamine synthetase
IQE94_10380	COG5001	Diguanylate cyclase
IQE94_10380	COG3706	GGDEF domain
IQE94_10380	COG4251	negative regulation of phosphorylation
IQE94_10380	COG2203	Gaf domain
IQE94_10390	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IQE94_10405	COG0076	glutamate decarboxylase activity
IQE94_10420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IQE94_10425	COG0829	nickel cation binding
IQE94_10445	COG1045	serine acetyltransferase
IQE94_10465	COG0412	Dienelactone hydrolase
IQE94_10470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IQE94_10475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IQE94_10480	COG1294	oxidase, subunit
IQE94_10485	COG1271	oxidase subunit
IQE94_10495	COG0681	Belongs to the peptidase S26 family
IQE94_10505	COG2226	methyltransferase
IQE94_10520	COG3937	granule-associated protein
IQE94_10525	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IQE94_10525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IQE94_10530	COG0745	RESPONSE REGULATOR receiver
IQE94_10540	COG0668	transmembrane transport
IQE94_10550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IQE94_10565	COG0438	transferase activity, transferring glycosyl groups
IQE94_10575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IQE94_10575	COG2205	protein histidine kinase activity
IQE94_10580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IQE94_10585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IQE94_10595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IQE94_10600	COG3259	Nickel-dependent hydrogenase
IQE94_10615	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
IQE94_10620	COG1034	ATP synthesis coupled electron transport
IQE94_10645	COG0409	Hydrogenase expression formation protein
IQE94_10655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IQE94_10660	COG0297	glycogen (starch) synthase activity
IQE94_10675	COG1131	(ABC) transporter
IQE94_10690	COG0668	transmembrane transport
IQE94_10720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IQE94_10725	COG1121	(ABC) transporter
IQE94_10730	COG0803	Belongs to the bacterial solute-binding protein 9 family
IQE94_10765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IQE94_10780	COG0163	prenyltransferase activity
IQE94_10790	COG0589	response to stress
IQE94_10795	COG1716	ATPase activity
IQE94_10795	COG5001	Diguanylate cyclase
IQE94_10800	COG1716	ATPase activity
IQE94_10800	COG5001	Diguanylate cyclase
IQE94_10810	COG1217	gtp-binding protein TYPA
IQE94_10830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IQE94_10840	COG0442	prolyl-tRNA aminoacylation
IQE94_10850	COG4372	Transposase
IQE94_10855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IQE94_10870	COG3588	fructose-bisphosphate aldolase
IQE94_10875	COG0656	L-ascorbic acid biosynthetic process
IQE94_10880	COG4191	Histidine kinase
IQE94_10880	COG0784	Response regulator, receiver
IQE94_10895	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_10905	COG2816	NAD+ diphosphatase activity
IQE94_10910	COG0165	Argininosuccinate lyase
IQE94_10920	COG2208	phosphoserine phosphatase activity
IQE94_10940	COG0438	transferase activity, transferring glycosyl groups
IQE94_10945	COG0557	exoribonuclease II activity
IQE94_10975	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IQE94_10985	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IQE94_10990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IQE94_11000	COG0745	RESPONSE REGULATOR receiver
IQE94_11005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IQE94_11010	COG2217	Heavy metal translocating P-type atpase
IQE94_11020	COG3063	Type IV pilus biogenesis stability protein PilW
IQE94_11025	COG1132	(ABC) transporter
IQE94_11085	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQE94_11090	COG1006	Multisubunit Na H antiporter MnhC subunit
IQE94_11125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IQE94_11140	COG0587	DNA-directed DNA polymerase activity
IQE94_11145	COG0739	heme binding
IQE94_11155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IQE94_11160	COG2988	succinylglutamate desuccinylase activity
IQE94_11170	COG0515	serine threonine protein kinase
IQE94_11200	COG0237	dephospho-CoA kinase activity
IQE94_11205	COG0237	dephospho-CoA kinase activity
IQE94_11210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IQE94_11215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IQE94_11230	COG1596	polysaccharide export
IQE94_11240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IQE94_11245	COG3411	Ferredoxin
IQE94_11255	COG2385	sporulation resulting in formation of a cellular spore
IQE94_11265	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IQE94_11295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IQE94_11300	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IQE94_11305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IQE94_11310	COG0628	permease
IQE94_11325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IQE94_11330	COG0837	glucose binding
IQE94_11335	COG1132	(ABC) transporter
IQE94_11365	COG5002	protein histidine kinase activity
IQE94_11370	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
IQE94_11380	COG1309	transcriptional regulator
IQE94_11400	COG0024	Methionine aminopeptidase
IQE94_11405	COG4221	oxidoreductase activity
IQE94_11430	COG0625	glutathione transferase activity
IQE94_11455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IQE94_11460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IQE94_11470	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IQE94_11475	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IQE94_11525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IQE94_11525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IQE94_11535	COG0612	Peptidase, M16
IQE94_11540	COG0489	protein tyrosine kinase activity
IQE94_11545	COG0505	Belongs to the CarA family
IQE94_11555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IQE94_11580	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IQE94_11585	COG0006	proline dipeptidase activity
IQE94_11590	COG0740	serine-type endopeptidase activity
IQE94_11595	COG0740	serine-type endopeptidase activity
IQE94_11680	COG1459	type II secretion system
IQE94_11710	COG0542	response to heat
IQE94_11720	COG0528	UMP kinase activity
IQE94_11725	COG0233	cytoplasmic translational termination
IQE94_11790	COG0646	methionine synthase
IQE94_11790	COG1410	methionine synthase
IQE94_11795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IQE94_11810	COG2202	Pas domain
IQE94_11810	COG2205	protein histidine kinase activity
IQE94_11835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IQE94_11845	COG0824	Thioesterase
IQE94_11855	COG4178	(ABC) transporter
IQE94_11870	COG0762	integral membrane protein
IQE94_11875	COG2048	Heterodisulfide reductase, subunit B
IQE94_11885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IQE94_11890	COG0121	glutamine amidotransferase
IQE94_11900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IQE94_11915	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IQE94_11925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IQE94_11930	COG2385	sporulation resulting in formation of a cellular spore
IQE94_11930	COG2247	cell wall binding repeat
IQE94_11940	COG0792	nuclease activity
IQE94_11945	COG1546	Belongs to the CinA family
IQE94_11945	COG1058	Belongs to the CinA family
IQE94_11950	COG0302	gtp cyclohydrolase
IQE94_11955	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IQE94_11965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IQE94_11980	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IQE94_12015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IQE94_12035	COG0105	UTP biosynthetic process
IQE94_12055	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IQE94_12065	COG0501	Belongs to the peptidase M48B family
IQE94_12095	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IQE94_12105	COG0463	Glycosyl transferase, family 2
IQE94_12115	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IQE94_12130	COG0508	dehydrogenase complex catalyzes the overall conversion of
IQE94_12135	COG3093	addiction module antidote protein HigA
IQE94_12140	COG3549	Plasmid maintenance system killer
IQE94_12145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IQE94_12150	COG0515	serine threonine protein kinase
IQE94_12150	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_12160	COG2217	Heavy metal translocating P-type atpase
IQE94_12170	COG0217	transcriptional regulatory protein
IQE94_12175	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IQE94_12180	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IQE94_12185	COG0739	heme binding
IQE94_12190	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IQE94_12195	COG0321	lipoyl(octanoyl) transferase activity
IQE94_12210	COG0297	glycogen (starch) synthase activity
IQE94_12225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IQE94_12230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IQE94_12235	COG0784	Response regulator, receiver
IQE94_12235	COG0643	Histidine kinase
IQE94_12235	COG2198	Histidine kinase
IQE94_12235	COG0643	Histidine kinase
IQE94_12235	COG0784	Response regulator, receiver
IQE94_12235	COG2198	Histidine kinase
IQE94_12255	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_12260	COG0494	nUDIX hydrolase
IQE94_12265	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IQE94_12270	COG0039	L-malate dehydrogenase activity
IQE94_12285	COG0193	aminoacyl-tRNA hydrolase activity
IQE94_12315	COG0024	Methionine aminopeptidase
IQE94_12320	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
IQE94_12335	COG4243	Vitamin k epoxide reductase
IQE94_12340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IQE94_12340	COG0426	domain, Protein
IQE94_12350	COG2251	uridine kinase activity
IQE94_12355	COG3063	Type IV pilus biogenesis stability protein PilW
IQE94_12360	COG0023	Translation Initiation Factor
IQE94_12400	COG2954	triphosphatase activity
IQE94_12410	COG0401	homolog of Blt101
IQE94_12415	COG2211	Major facilitator Superfamily
IQE94_12440	COG4451	ribulose bisphosphate carboxylase, small
IQE94_12450	COG1850	ribulose-bisphosphate carboxylase activity
IQE94_12455	COG0793	Belongs to the peptidase S41A family
IQE94_12470	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IQE94_12475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IQE94_12480	COG0191	fructose-bisphosphate aldolase activity
IQE94_12485	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IQE94_12495	COG0542	response to heat
IQE94_12535	COG0124	histidyl-tRNA synthetase
IQE94_12545	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_12545	COG0515	serine threonine protein kinase
IQE94_12550	COG0601	transmembrane transport
IQE94_12560	COG1748	Saccharopine dehydrogenase
IQE94_12615	COG0339	signal peptide processing
IQE94_12620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IQE94_12635	COG1166	arginine decarboxylase activity
IQE94_12645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IQE94_12655	COG1049	propionate catabolic process, 2-methylcitrate cycle
IQE94_12690	COG5002	protein histidine kinase activity
IQE94_12695	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IQE94_12700	COG2308	Evidence 4 Homologs of previously reported genes of
IQE94_12730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IQE94_12740	COG0346	lactoylglutathione lyase activity
IQE94_12745	COG1028	Short-chain dehydrogenase reductase Sdr
IQE94_12750	COG0742	ribosomal rna small subunit methyltransferase
IQE94_12755	COG0438	transferase activity, transferring glycosyl groups
IQE94_12760	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IQE94_12770	COG1104	cysteine desulfurase activity
IQE94_12775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IQE94_12780	COG1376	ErfK ybiS ycfS ynhG family protein
IQE94_12800	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
IQE94_12810	COG3659	wide pore channel activity
IQE94_12815	COG0477	Major facilitator Superfamily
IQE94_12820	COG0515	serine threonine protein kinase
IQE94_12820	COG2815	serine threonine protein kinase
IQE94_12830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IQE94_12835	COG4636	protein conserved in cyanobacteria
IQE94_12845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IQE94_12850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IQE94_12855	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IQE94_12860	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IQE94_12865	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IQE94_12870	COG2003	Belongs to the UPF0758 family
IQE94_12875	COG1054	Belongs to the UPF0176 family
IQE94_12890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IQE94_12900	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IQE94_12905	COG2203	Gaf domain
IQE94_12905	COG5001	Diguanylate cyclase
IQE94_12905	COG4251	negative regulation of phosphorylation
IQE94_12905	COG3706	GGDEF domain
IQE94_12915	COG0471	metal ion transport
IQE94_12915	COG3273	potassium ion transport
IQE94_12945	COG3854	ATPases associated with a variety of cellular activities
IQE94_12950	COG0352	thiamine-phosphate diphosphorylase activity
IQE94_12955	COG0434	BtpA family
IQE94_12980	COG0564	pseudouridine synthase activity
IQE94_12985	COG2203	Gaf domain
IQE94_12985	COG5001	Diguanylate cyclase
IQE94_12985	COG4251	negative regulation of phosphorylation
IQE94_12985	COG3706	GGDEF domain
IQE94_13015	COG0668	transmembrane transport
IQE94_13025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IQE94_13030	COG1733	regulation of RNA biosynthetic process
IQE94_13035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IQE94_13075	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IQE94_13100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IQE94_13125	COG0436	Aminotransferase
IQE94_13130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IQE94_13145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IQE94_13150	COG0616	signal peptide processing
IQE94_13155	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IQE94_13165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IQE94_13165	COG0519	Catalyzes the synthesis of GMP from XMP
IQE94_13255	COG0631	protein serine/threonine phosphatase activity
IQE94_13260	COG2815	serine threonine protein kinase
IQE94_13260	COG0515	serine threonine protein kinase
IQE94_13265	COG1968	undecaprenyl-diphosphatase activity
IQE94_13285	COG5322	oxidoreductase activity
IQE94_13290	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
IQE94_13300	COG0751	glycine-tRNA ligase activity
IQE94_13310	COG0586	Pfam SNARE associated Golgi protein
IQE94_13315	COG3118	belongs to the thioredoxin family
IQE94_13320	COG3751	2OG-Fe(II) oxygenase superfamily
IQE94_13325	COG0459	protein refolding
IQE94_13330	COG1131	(ABC) transporter
IQE94_13345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IQE94_13345	COG0515	serine threonine protein kinase
IQE94_13360	COG4399	Belongs to the UPF0754 family
IQE94_13365	COG0824	Thioesterase
IQE94_13370	COG4948	Mandelate Racemase Muconate Lactonizing
IQE94_13375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IQE94_13380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IQE94_13385	COG0511	ligase activity, forming carbon-carbon bonds
IQE94_13390	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IQE94_13410	COG0277	FAD linked oxidase domain protein
IQE94_13425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IQE94_13435	COG1494	fructose-1,6-bisphosphatase
IQE94_13440	COG2153	protein acetylation
IQE94_13475	COG2197	response regulator
IQE94_13490	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IQE94_13515	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IQE94_13545	COG3706	GGDEF domain
IQE94_13545	COG5001	Diguanylate cyclase
IQE94_13545	COG4251	negative regulation of phosphorylation
IQE94_13545	COG2203	Gaf domain
IQE94_13550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IQE94_13565	COG3659	wide pore channel activity
IQE94_13570	COG1473	amidohydrolase
IQE94_13575	COG0170	dolichyl monophosphate biosynthetic process
IQE94_13620	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IQE94_13625	COG4251	negative regulation of phosphorylation
IQE94_13650	COG1598	PFAM Uncharacterised protein family UPF0150
IQE94_13665	COG0825	malonyl-CoA metabolic process
IQE94_13680	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IQE94_13695	COG0148	phosphopyruvate hydratase activity
IQE94_13700	COG0457	Tetratricopeptide repeat
IQE94_13710	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
IQE94_13720	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
IQE94_13730	COG1543	Belongs to the glycosyl hydrolase 57 family
IQE94_13740	COG3842	ATPase activity
IQE94_13750	COG1716	ATPase activity
IQE94_13750	COG5001	Diguanylate cyclase
IQE94_13755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IQE94_13780	COG0702	epimerase
IQE94_13795	COG0714	Associated with various cellular activities
IQE94_13800	COG0305	Participates in initiation and elongation during chromosome replication
IQE94_13800	COG1372	Participates in initiation and elongation during chromosome replication
IQE94_13815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IQE94_13820	COG0659	secondary active sulfate transmembrane transporter activity
IQE94_13825	COG3706	GGDEF domain
IQE94_13825	COG4251	negative regulation of phosphorylation
IQE94_13825	COG5001	Diguanylate cyclase
IQE94_13825	COG2203	Gaf domain
IQE94_13830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IQE94_13840	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IQE94_13845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IQE94_13860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IQE94_13885	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
IQE94_13900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IQE94_13915	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IQE94_13935	COG2385	sporulation resulting in formation of a cellular spore
IQE94_13940	COG0649	NAD binding
IQE94_14045	COG0418	dihydroorotase activity
IQE94_14090	COG1070	Carbohydrate kinase
IQE94_14095	COG2166	iron-sulfur cluster assembly
IQE94_14115	COG0515	serine threonine protein kinase
IQE94_14125	COG0435	Glutathione S-transferase
IQE94_14145	COG0140	phosphoribosyl-ATP diphosphatase activity
IQE94_14145	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IQE94_14150	COG0523	cobalamin synthesis protein
IQE94_14160	COG0142	geranyltranstransferase activity
IQE94_14165	COG1187	pseudouridine synthase activity
IQE94_14175	COG0515	serine threonine protein kinase
IQE94_14180	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
IQE94_14185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IQE94_14190	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IQE94_14210	COG1166	arginine decarboxylase activity
IQE94_14215	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IQE94_14225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IQE94_14230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IQE94_14235	COG1120	ATPase activity
IQE94_14240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IQE94_14250	COG2207	Transcriptional regulator
IQE94_14280	COG2226	methyltransferase
IQE94_14290	COG0848	biopolymer transport protein
IQE94_14295	COG0811	peptide transport
IQE94_14310	COG1132	(ABC) transporter
IQE94_14315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IQE94_14360	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IQE94_14370	COG5002	protein histidine kinase activity
IQE94_14385	COG0363	glucosamine-6-phosphate deaminase activity
IQE94_14400	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IQE94_14435	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IQE94_14435	COG3264	Mechanosensitive ion channel
IQE94_14440	COG2052	Domain of unknown function (DUF370)
IQE94_14445	COG1496	oxidoreductase activity
IQE94_14465	COG0739	heme binding
IQE94_14470	COG1691	(AIR) carboxylase
IQE94_14485	COG2319	Wd-40 repeat
IQE94_14495	COG0316	Belongs to the HesB IscA family
IQE94_14500	COG1191	sigma factor activity
IQE94_14505	COG3001	Fructosamine kinase
IQE94_14510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IQE94_14515	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IQE94_14520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IQE94_14530	COG0579	oxidoreductase
IQE94_14545	COG2318	DinB family
IQE94_14585	COG1615	UPF0182 protein
IQE94_14600	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IQE94_14605	COG1174	glycine betaine transport
IQE94_14610	COG0563	adenylate kinase activity
IQE94_14615	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IQE94_14620	COG3118	belongs to the thioredoxin family
IQE94_14645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IQE94_14655	COG0494	nUDIX hydrolase
IQE94_14660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IQE94_14665	COG0194	GDP metabolic process
IQE94_14670	COG0406	alpha-ribazole phosphatase activity
IQE94_14680	COG0730	response to heat
IQE94_14685	COG1413	lyase activity
IQE94_14700	COG0330	HflC and HflK could
IQE94_14710	COG1530	ribonuclease E activity
IQE94_14715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IQE94_14720	COG0494	nUDIX hydrolase
IQE94_14725	COG1185	polyribonucleotide nucleotidyltransferase activity
IQE94_14730	COG0681	Belongs to the peptidase S26 family
IQE94_14750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IQE94_14755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IQE94_14770	COG0484	heat shock protein binding
IQE94_14800	COG1104	cysteine desulfurase activity
IQE94_14835	COG0582	viral genome integration into host DNA
IQE94_14845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IQE94_14845	COG2022	thiamine diphosphate biosynthetic process
IQE94_14850	COG5002	protein histidine kinase activity
IQE94_14860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IQE94_14880	COG0704	Plays a role in the regulation of phosphate uptake
IQE94_14885	COG0779	Required for maturation of 30S ribosomal subunits
IQE94_14890	COG0195	Participates in both transcription termination and antitermination
IQE94_14900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IQE94_14920	COG0012	GTP binding
IQE94_14925	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IQE94_14940	COG0716	FMN binding
IQE94_14945	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
IQE94_14950	COG3536	Protein conserved in bacteria
IQE94_14955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IQE94_14960	COG0429	hydrolase of the alpha beta-hydrolase fold
IQE94_14965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IQE94_14985	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IQE94_14990	COG2198	Histidine kinase
IQE94_14990	COG0784	Response regulator, receiver
IQE94_14990	COG0643	Histidine kinase
IQE94_14995	COG0840	transmembrane signaling receptor activity
IQE94_15010	COG0784	Response regulator, receiver
IQE94_15015	COG0557	exoribonuclease II activity
IQE94_15025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IQE94_15040	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IQE94_15050	COG3956	TIGRFAM MazG family protein
IQE94_15060	COG5002	protein histidine kinase activity
IQE94_15060	COG3447	MASE1 domain protein
IQE94_15060	COG5001	Diguanylate cyclase
IQE94_15070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IQE94_15095	COG4447	cellulose binding
IQE94_15100	COG1773	rubredoxin
IQE94_15105	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IQE94_15130	COG0804	urea catabolic process
IQE94_15145	COG0398	Pfam SNARE associated Golgi protein
IQE94_15155	COG2226	methyltransferase
IQE94_15160	COG0398	Pfam SNARE associated Golgi protein
IQE94_15190	COG0574	Belongs to the PEP-utilizing enzyme family
IQE94_15190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IQE94_15200	COG1716	ATPase activity
IQE94_15205	COG0850	regulation of cytokinetic process
IQE94_15210	COG2894	cell division
IQE94_15215	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IQE94_15230	COG2165	general secretion pathway protein
IQE94_15280	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IQE94_15290	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
IQE94_15295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IQE94_15295	COG2022	thiamine diphosphate biosynthetic process
IQE94_15300	COG2255	four-way junction helicase activity
IQE94_15310	COG0653	protein targeting
IQE94_15325	COG1842	Phage shock protein A
IQE94_15330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IQE94_15345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IQE94_15360	COG0581	inorganic phosphate transmembrane transporter activity
IQE94_15365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IQE94_15370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IQE94_15375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IQE94_15380	COG4232	protein-disulfide reductase activity
IQE94_15395	COG0475	glutathione-regulated potassium exporter activity
IQE94_15415	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IQE94_15425	COG2091	lysine biosynthetic process via aminoadipic acid
IQE94_15430	COG0460	homoserine dehydrogenase
IQE94_15445	COG0318	PFAM AMP-dependent synthetase and ligase
IQE94_15460	COG0728	peptidoglycan biosynthetic process
IQE94_15470	COG5002	protein histidine kinase activity
IQE94_15475	COG0525	valine-tRNA ligase activity
IQE94_15495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IQE94_15510	COG0556	nucleotide-excision repair
IQE94_15525	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IQE94_15530	COG1468	defense response to virus
IQE94_15530	COG1518	maintenance of DNA repeat elements
IQE94_15555	COG1857	crispr-associated protein
IQE94_15565	COG1203	CRISPR-associated helicase, Cas3
IQE94_15580	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IQE94_15590	COG1127	ABC transporter
IQE94_15600	COG0697	spore germination
IQE94_15605	COG0316	Belongs to the HesB IscA family
IQE94_15610	COG0714	Associated with various cellular activities
IQE94_15620	COG2205	protein histidine kinase activity
IQE94_15635	COG0356	it plays a direct role in the translocation of protons across the membrane
IQE94_15640	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IQE94_15645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IQE94_15650	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IQE94_15660	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IQE94_15665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IQE94_15680	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IQE94_15685	COG0009	L-threonylcarbamoyladenylate synthase
IQE94_15690	COG0793	Belongs to the peptidase S41A family
IQE94_15700	COG0426	domain, Protein
IQE94_15700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IQE94_15710	COG0426	domain, Protein
IQE94_15710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IQE94_15720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IQE94_15725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IQE94_15755	COG1598	PFAM Uncharacterised protein family UPF0150
IQE94_15785	COG4245	von Willebrand factor, type A
IQE94_15790	COG1007	ATP synthesis coupled electron transport
IQE94_15800	COG2099	Precorrin-6x reductase
IQE94_15840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IQE94_15845	COG0010	Belongs to the arginase family
IQE94_15850	COG0123	including yeast histone deacetylase and acetoin utilization protein
IQE94_15860	COG0589	response to stress
IQE94_15865	COG0011	TIGRFAM Protein of
IQE94_15875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IQE94_15880	COG0501	Belongs to the peptidase M48B family
IQE94_15905	COG0457	Tetratricopeptide repeat
IQE94_15905	COG0463	Glycosyl transferase, family 2
IQE94_15920	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IQE94_15935	COG3118	belongs to the thioredoxin family
IQE94_15940	COG2081	HI0933 family
IQE94_15945	COG0469	pyruvate kinase activity
IQE94_15955	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IQE94_15975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IQE94_15980	COG0745	RESPONSE REGULATOR receiver
IQE94_15985	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IQE94_16000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IQE94_16000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IQE94_16005	COG0848	biopolymer transport protein
IQE94_16010	COG0811	peptide transport
IQE94_16015	COG0529	Catalyzes the synthesis of activated sulfate
IQE94_16020	COG0737	Belongs to the 5'-nucleotidase family
IQE94_16030	COG2205	protein histidine kinase activity
IQE94_16040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IQE94_16045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IQE94_16055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IQE94_16080	COG0861	Integral membrane protein TerC family
IQE94_16085	COG0045	succinate-CoA ligase (ADP-forming) activity
IQE94_16090	COG3781	membrane
IQE94_16115	COG0110	maltose O-acetyltransferase activity
IQE94_16145	COG0438	transferase activity, transferring glycosyl groups
IQE94_16160	COG0275	rRNA processing
IQE94_16215	COG0438	transferase activity, transferring glycosyl groups
IQE94_16235	COG1215	transferase activity, transferring glycosyl groups
IQE94_16260	COG2089	acid synthase
IQE94_16320	COG1598	PFAM Uncharacterised protein family UPF0150
IQE94_16380	COG1598	PFAM Uncharacterised protein family UPF0150
IQE94_16440	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IQE94_16445	COG4636	protein conserved in cyanobacteria
IQE94_16450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IQE94_16455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IQE94_16475	COG0701	Predicted permease
IQE94_16480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IQE94_16490	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IQE94_16510	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IQE94_16520	COG0523	cobalamin synthesis protein
IQE94_16535	COG0436	Aminotransferase
IQE94_16550	COG0159	tryptophan synthase activity
IQE94_16555	COG0592	DNA-directed DNA polymerase activity
IQE94_16560	COG0672	)-iron permease
IQE94_16565	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IQE94_16580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IQE94_16595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IQE94_16600	COG0573	inorganic phosphate transmembrane transporter activity
IQE94_16605	COG0581	inorganic phosphate transmembrane transporter activity
IQE94_16610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IQE94_16640	COG1381	Involved in DNA repair and RecF pathway recombination
IQE94_16680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IQE94_16690	COG1304	FMN binding
IQE94_16695	COG0745	RESPONSE REGULATOR receiver
IQE94_16710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IQE94_16720	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IQE94_16720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IQE94_16725	COG2203	Gaf domain
IQE94_16725	COG3706	GGDEF domain
IQE94_16725	COG4251	negative regulation of phosphorylation
IQE94_16725	COG5001	Diguanylate cyclase
IQE94_16730	COG0784	Response regulator, receiver
IQE94_16740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IQE94_16740	COG0072	phenylalanine-tRNA ligase activity
IQE94_16745	COG0515	serine threonine protein kinase
IQE94_16745	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_16750	COG2197	response regulator
IQE94_16755	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IQE94_16780	COG0157	Belongs to the NadC ModD family
IQE94_16795	COG2082	Precorrin-8x methylmutase
IQE94_16800	COG0612	Peptidase, M16
IQE94_16805	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IQE94_16820	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IQE94_16825	COG4251	negative regulation of phosphorylation
IQE94_16830	COG0481	GTPase activity
IQE94_16835	COG0587	DNA-directed DNA polymerase activity
IQE94_16855	COG0515	serine threonine protein kinase
IQE94_16875	COG0138	bifunctional purine biosynthesis protein purh
IQE94_16885	COG0735	belongs to the Fur family
IQE94_16890	COG0577	efflux transmembrane transporter activity
IQE94_16890	COG1136	(ABC) transporter
IQE94_16895	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IQE94_16900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IQE94_16915	COG0549	Belongs to the carbamate kinase family
IQE94_16920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IQE94_16945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IQE94_16955	COG3621	Patatin-like phospholipase
IQE94_16975	COG1357	PFAM Pentapeptide repeats (8 copies)
IQE94_16980	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IQE94_16995	COG0137	argininosuccinate synthase activity
IQE94_17010	COG1064	alcohol dehydrogenase
IQE94_17030	COG1842	Phage shock protein A
IQE94_17040	COG5001	Diguanylate cyclase
IQE94_17040	COG3300	MHYT domain
IQE94_17055	COG5002	protein histidine kinase activity
IQE94_17065	COG0723	plastoquinol--plastocyanin reductase activity
IQE94_17100	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IQE94_17110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IQE94_17115	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IQE94_17130	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IQE94_17135	COG0326	Molecular chaperone. Has ATPase activity
IQE94_17140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IQE94_17145	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IQE94_17150	COG2226	methyltransferase
IQE94_17155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IQE94_17160	COG0154	amidase activity
IQE94_17180	COG2203	Gaf domain
IQE94_17180	COG3706	GGDEF domain
IQE94_17180	COG4251	negative regulation of phosphorylation
IQE94_17180	COG5001	Diguanylate cyclase
IQE94_17195	COG0732	type I restriction modification DNA specificity domain
IQE94_17245	COG0617	tRNA 3'-terminal CCA addition
IQE94_17255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IQE94_17270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IQE94_17280	COG1959	2 iron, 2 sulfur cluster binding
IQE94_17285	COG5001	Diguanylate cyclase
IQE94_17285	COG4251	negative regulation of phosphorylation
IQE94_17285	COG3706	GGDEF domain
IQE94_17285	COG2203	Gaf domain
IQE94_17290	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IQE94_17300	COG0357	Ribosomal RNA small subunit methyltransferase G
IQE94_17305	COG2198	Histidine kinase
IQE94_17305	COG0643	Histidine kinase
IQE94_17315	COG0719	Fe-S assembly protein
IQE94_17320	COG0396	ATPase activity
IQE94_17325	COG0719	Fe-S assembly protein
IQE94_17330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IQE94_17335	COG0003	Pfam Anion-transporting ATPase
IQE94_17345	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IQE94_17350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IQE94_17355	COG0720	synthase
IQE94_17370	COG0328	RNA-DNA hybrid ribonuclease activity
IQE94_17375	COG0745	RESPONSE REGULATOR receiver
IQE94_17380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IQE94_17385	COG0513	Belongs to the DEAD box helicase family
IQE94_17390	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IQE94_17395	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IQE94_17400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IQE94_17405	COG0443	Heat shock 70 kDa protein
IQE94_17415	COG2226	methyltransferase
IQE94_17420	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IQE94_17425	COG1012	belongs to the aldehyde dehydrogenase family
IQE94_17430	COG1216	Glycosyl transferase, family 2
IQE94_17435	COG0484	heat shock protein binding
IQE94_17445	COG0659	secondary active sulfate transmembrane transporter activity
IQE94_17455	COG1131	(ABC) transporter
IQE94_17460	COG0131	Imidazoleglycerol-phosphate dehydratase
IQE94_17470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IQE94_17475	COG4251	negative regulation of phosphorylation
IQE94_17480	COG2197	response regulator
IQE94_17485	COG1136	(ABC) transporter
IQE94_17485	COG0577	efflux transmembrane transporter activity
IQE94_17495	COG0515	serine threonine protein kinase
IQE94_17505	COG1028	Short-chain dehydrogenase reductase Sdr
IQE94_17520	COG0436	Aminotransferase
IQE94_17525	COG0586	Pfam SNARE associated Golgi protein
IQE94_17530	COG3264	Mechanosensitive ion channel
IQE94_17530	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IQE94_17535	COG1012	belongs to the aldehyde dehydrogenase family
IQE94_17550	COG1122	ATPase activity
IQE94_17555	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IQE94_17610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IQE94_17640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IQE94_17840	COG1468	defense response to virus
IQE94_17840	COG1518	maintenance of DNA repeat elements
IQE94_17890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IQE94_17900	COG1028	Short-chain dehydrogenase reductase Sdr
IQE94_17910	COG1846	Transcriptional regulator
IQE94_17930	COG1028	Short-chain dehydrogenase reductase Sdr
IQE94_17940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IQE94_17950	COG4221	oxidoreductase activity
IQE94_17955	COG2124	cytochrome p450
IQE94_17970	COG0508	dehydrogenase complex catalyzes the overall conversion of
IQE94_17970	COG0596	Alpha beta hydrolase
IQE94_17985	COG1902	pentaerythritol trinitrate reductase activity
IQE94_18000	COG4585	Histidine kinase
IQE94_18005	COG2197	response regulator
IQE94_18085	COG1404	Belongs to the peptidase S8 family
IQE94_18090	COG0464	growth
IQE94_18110	COG3961	Belongs to the TPP enzyme family
IQE94_18140	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IQE94_18160	COG2211	Major facilitator Superfamily
IQE94_18185	COG0270	DNA (cytosine-5-)-methyltransferase activity
IQE94_18200	COG0702	epimerase
IQE94_18260	COG2340	Cysteine-rich secretory protein family