locus-tag	class	description
KIH16_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KIH16_00010	COG0592	DNA-directed DNA polymerase activity
KIH16_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KIH16_00020	COG0445	tRNA wobble uridine modification
KIH16_00035	COG2358	TRAP transporter, solute receptor (TAXI family
KIH16_00065	COG2033	superoxide reductase activity
KIH16_00080	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
KIH16_00095	COG0440	acetolactate synthase activity
KIH16_00100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KIH16_00105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KIH16_00110	COG0028	Belongs to the TPP enzyme family
KIH16_00120	COG0840	transmembrane signaling receptor activity
KIH16_00125	COG2827	Endonuclease containing a URI domain
KIH16_00130	COG0531	amino acid
KIH16_00140	COG0583	DNA-binding transcription factor activity
KIH16_00150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KIH16_00170	COG1979	alcohol dehydrogenase
KIH16_00180	COG1473	amidohydrolase
KIH16_00185	COG0840	transmembrane signaling receptor activity
KIH16_00190	COG2801	Transposase and inactivated derivatives
KIH16_00195	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KIH16_00230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KIH16_00235	COG1116	anion transmembrane transporter activity
KIH16_00270	COG2116	formate transmembrane transporter activity
KIH16_00275	COG0746	molybdenum cofactor guanylyltransferase activity
KIH16_00305	COG0561	phosphatase activity
KIH16_00325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KIH16_00340	COG1606	tRNA processing
KIH16_00350	COG1012	belongs to the aldehyde dehydrogenase family
KIH16_00355	COG1525	nuclease
KIH16_00370	COG0357	Ribosomal RNA small subunit methyltransferase G
KIH16_00375	COG1192	Involved in chromosome partitioning
KIH16_00380	COG1475	DNA binding
KIH16_00395	COG1739	Uncharacterized protein family UPF0029
KIH16_00400	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KIH16_00415	COG0189	ligase activity
KIH16_00420	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KIH16_00425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KIH16_00430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KIH16_00435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KIH16_00440	COG1136	(ABC) transporter
KIH16_00440	COG0577	efflux transmembrane transporter activity
KIH16_00445	COG1136	(ABC) transporter
KIH16_00445	COG0577	efflux transmembrane transporter activity
KIH16_00460	COG0745	RESPONSE REGULATOR receiver
KIH16_00465	COG2205	protein histidine kinase activity
KIH16_00480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KIH16_00495	COG2204	response regulator
KIH16_00500	COG5002	protein histidine kinase activity
KIH16_00505	COG2205	protein histidine kinase activity
KIH16_00510	COG0745	RESPONSE REGULATOR receiver
KIH16_00535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KIH16_00560	COG1132	(ABC) transporter
KIH16_00565	COG1309	transcriptional regulator
KIH16_00575	COG0640	Transcriptional regulator
KIH16_00580	COG0840	transmembrane signaling receptor activity
KIH16_00605	COG0840	transmembrane signaling receptor activity
KIH16_00615	COG1619	proteins homologs of microcin C7 resistance protein MccF
KIH16_00625	COG0444	Belongs to the ABC transporter superfamily
KIH16_00630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KIH16_00635	COG0601	transmembrane transport
KIH16_00640	COG0747	negative chemotaxis
KIH16_00650	COG0673	inositol 2-dehydrogenase activity
KIH16_00655	COG3681	Belongs to the UPF0597 family
KIH16_00670	COG3437	response regulator, receiver
KIH16_00675	COG0840	transmembrane signaling receptor activity
KIH16_00690	COG3447	MASE1 domain protein
KIH16_00690	COG5001	Diguanylate cyclase
KIH16_00690	COG5002	protein histidine kinase activity
KIH16_00695	COG2208	phosphoserine phosphatase activity
KIH16_00700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KIH16_00710	COG1366	Belongs to the anti-sigma-factor antagonist family
KIH16_00715	COG1472	Belongs to the glycosyl hydrolase 3 family
KIH16_00750	COG0426	domain, Protein
KIH16_00775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KIH16_00785	COG0704	Plays a role in the regulation of phosphate uptake
KIH16_00795	COG0840	transmembrane signaling receptor activity
KIH16_00815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KIH16_00825	COG1129	ABC transporter
KIH16_00830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KIH16_00835	COG1172	Belongs to the binding-protein-dependent transport system permease family
KIH16_00840	COG1172	Belongs to the binding-protein-dependent transport system permease family
KIH16_00845	COG1609	Transcriptional regulator
KIH16_00850	COG1744	ABC transporter substrate-binding protein PnrA-like
KIH16_00855	COG3845	ABC transporter
KIH16_00860	COG1079	Belongs to the binding-protein-dependent transport system permease family
KIH16_00865	COG1079	Belongs to the binding-protein-dependent transport system permease family
KIH16_00875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KIH16_00885	COG1473	amidohydrolase
KIH16_00895	COG1124	(ABC) transporter
KIH16_00900	COG0444	Belongs to the ABC transporter superfamily
KIH16_00905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KIH16_00910	COG0601	transmembrane transport
KIH16_00915	COG0747	negative chemotaxis
KIH16_00930	COG4166	transmembrane transport
KIH16_00935	COG0601	transmembrane transport
KIH16_00940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KIH16_00945	COG0444	Belongs to the ABC transporter superfamily
KIH16_00950	COG4608	Belongs to the ABC transporter superfamily
KIH16_00965	COG4948	Mandelate Racemase Muconate Lactonizing
KIH16_00970	COG0583	DNA-binding transcription factor activity
KIH16_00975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KIH16_01020	COG2226	methyltransferase
KIH16_01030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KIH16_01050	COG1917	Cupin 2, conserved barrel domain protein
KIH16_01050	COG2207	Transcriptional regulator
KIH16_01085	COG0784	Response regulator, receiver
KIH16_01085	COG3437	response regulator, receiver
KIH16_01090	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
KIH16_01105	COG1918	ferrous iron import across plasma membrane
KIH16_01105	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KIH16_01130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KIH16_01135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KIH16_01140	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KIH16_01155	COG0456	acetyltransferase
KIH16_01155	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KIH16_01160	COG1074	ATP-dependent DNA helicase activity
KIH16_01195	COG2414	aldehyde ferredoxin oxidoreductase
KIH16_01200	COG0277	FAD linked oxidase domain protein
KIH16_01205	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KIH16_01210	COG2086	electron transfer activity
KIH16_01215	COG3875	lactate racemase activity
KIH16_01220	COG2186	Transcriptional regulator
KIH16_01240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KIH16_01245	COG1518	maintenance of DNA repeat elements
KIH16_01260	COG1857	crispr-associated protein
KIH16_01275	COG1203	CRISPR-associated helicase, Cas3
KIH16_01285	COG0402	S-adenosylhomocysteine deaminase activity
KIH16_01290	COG0493	'glutamate synthase
KIH16_01290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KIH16_01295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KIH16_01300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KIH16_01315	COG2252	PERMEase
KIH16_01330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KIH16_01340	COG2235	arginine
KIH16_01345	COG4187	Peptidase family M20/M25/M40
KIH16_01350	COG1115	amino acid carrier protein
KIH16_01360	COG1522	sequence-specific DNA binding
KIH16_01365	COG4106	trans-aconitate 2-methyltransferase activity
KIH16_01375	COG0534	Mate efflux family protein
KIH16_01380	COG1301	dicarboxylic acid transport
KIH16_01385	COG3706	GGDEF domain
KIH16_01410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KIH16_01420	COG4608	Belongs to the ABC transporter superfamily
KIH16_01425	COG0444	Belongs to the ABC transporter superfamily
KIH16_01430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KIH16_01435	COG0601	transmembrane transport
KIH16_01495	COG1464	Belongs to the NlpA lipoprotein family
KIH16_01500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KIH16_01505	COG2011	ABC-type metal ion transport system permease component
KIH16_01515	COG2271	Major facilitator Superfamily
KIH16_01530	COG2414	aldehyde ferredoxin oxidoreductase
KIH16_01535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KIH16_01550	COG4608	Belongs to the ABC transporter superfamily
KIH16_01555	COG0444	Belongs to the ABC transporter superfamily
KIH16_01560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KIH16_01565	COG0601	transmembrane transport
KIH16_01570	COG4166	transmembrane transport
KIH16_01575	COG0006	proline dipeptidase activity
KIH16_01580	COG1615	UPF0182 protein
KIH16_01600	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KIH16_01610	COG1047	Peptidyl-prolyl cis-trans
KIH16_01615	COG1164	Oligoendopeptidase f
KIH16_01630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KIH16_01635	COG1473	amidohydrolase
KIH16_01645	COG3404	Formiminotransferase-cyclodeaminase
KIH16_01650	COG1228	amidohydrolase
KIH16_01670	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KIH16_01670	COG3608	succinylglutamate desuccinylase aspartoacylase
KIH16_01685	COG3842	ATPase activity
KIH16_01690	COG4149	molybdate abc transporter
KIH16_01730	COG0535	radical SAM domain protein
KIH16_01765	COG0405	Gamma-glutamyltransferase
KIH16_01795	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KIH16_01800	COG0460	homoserine dehydrogenase
KIH16_01805	COG0840	transmembrane signaling receptor activity
KIH16_01815	COG3426	butyrate kinase activity
KIH16_01820	COG0280	phosphate acetyltransferase
KIH16_01825	COG0280	phosphate acetyltransferase
KIH16_01830	COG3426	butyrate kinase activity
KIH16_01840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KIH16_01845	COG1045	serine acetyltransferase
KIH16_01855	COG2217	Heavy metal translocating P-type atpase
KIH16_01865	COG0187	DNA topoisomerase II activity
KIH16_01875	COG0840	transmembrane signaling receptor activity
KIH16_01905	COG0840	transmembrane signaling receptor activity
KIH16_01915	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KIH16_01915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KIH16_01920	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KIH16_01930	COG2814	Major facilitator Superfamily
KIH16_01940	COG1181	Belongs to the D-alanine--D-alanine ligase family
KIH16_01945	COG1181	Belongs to the D-alanine--D-alanine ligase family
KIH16_01955	COG4608	Belongs to the ABC transporter superfamily
KIH16_01965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KIH16_01970	COG0601	transmembrane transport
KIH16_01975	COG4166	transmembrane transport
KIH16_01980	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KIH16_01985	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KIH16_01990	COG1489	DNA binding
KIH16_02010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KIH16_02015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KIH16_02030	COG0747	negative chemotaxis
KIH16_02040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KIH16_02045	COG0444	Belongs to the ABC transporter superfamily
KIH16_02070	COG2814	Major facilitator Superfamily
KIH16_02075	COG0617	tRNA 3'-terminal CCA addition
KIH16_02085	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KIH16_02090	COG1136	(ABC) transporter
KIH16_02090	COG0577	efflux transmembrane transporter activity
KIH16_02095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KIH16_02100	COG1760	l-serine dehydratase
KIH16_02105	COG1760	l-serine dehydratase
KIH16_02115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KIH16_02120	COG0688	phosphatidylethanolamine metabolic process
KIH16_02125	COG1183	phosphatidylcholine synthase activity
KIH16_02130	COG3859	Proton-coupled thiamine transporter YuaJ
KIH16_02135	COG0426	domain, Protein
KIH16_02145	COG2801	Transposase and inactivated derivatives
KIH16_02150	COG0513	Belongs to the DEAD box helicase family
KIH16_02160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KIH16_02160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KIH16_02165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KIH16_02165	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KIH16_02170	COG0346	lactoylglutathione lyase activity
KIH16_02175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KIH16_02190	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
KIH16_02205	COG0281	malic enzyme
KIH16_02230	COG0038	chloride channel
KIH16_02240	COG1752	Esterase of the alpha-beta hydrolase superfamily
KIH16_02245	COG0442	prolyl-tRNA aminoacylation
KIH16_02285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KIH16_02295	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KIH16_02300	COG0450	alkyl hydroperoxide reductase
KIH16_02310	COG1773	rubredoxin
KIH16_02310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KIH16_02345	COG0515	serine threonine protein kinase
KIH16_02350	COG2771	luxR family
KIH16_02350	COG2200	EAL domain
KIH16_02390	COG0583	DNA-binding transcription factor activity
KIH16_02395	COG0739	heme binding
KIH16_02395	COG1196	nuclear chromosome segregation
KIH16_02395	COG0741	lytic transglycosylase activity
KIH16_02400	COG0442	prolyl-tRNA aminoacylation
KIH16_02410	COG0252	asparaginase activity
KIH16_02420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KIH16_02425	COG0784	Response regulator, receiver
KIH16_02425	COG0835	chemotaxis
KIH16_02455	COG0419	ATPase involved in DNA repair
KIH16_02455	COG0419	ATPase involved in DNA repair
KIH16_02470	COG2197	response regulator
KIH16_02475	COG4585	Histidine kinase
KIH16_02480	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KIH16_02490	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KIH16_02495	COG0446	pyridine nucleotide-disulphide oxidoreductase
KIH16_02510	COG1560	Kdo2-lipid A biosynthetic process
KIH16_02525	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KIH16_02530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KIH16_02535	COG2376	Dihydroxyacetone kinase
KIH16_02540	COG1461	Dihydroxyacetone kinase
KIH16_02550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KIH16_02560	COG0493	'glutamate synthase
KIH16_02575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KIH16_02600	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KIH16_02610	COG0835	chemotaxis
KIH16_02625	COG0312	modulator of DNA gyrase
KIH16_02640	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KIH16_02645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KIH16_02660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KIH16_02665	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KIH16_02675	COG3290	protein histidine kinase activity
KIH16_02680	COG4565	transcriptional regulatory protein
KIH16_02705	COG1566	PFAM secretion protein HlyD family protein
KIH16_02750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KIH16_02760	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KIH16_02765	COG0250	Participates in transcription elongation, termination and antitermination
KIH16_02775	COG0081	regulation of translation
KIH16_02780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KIH16_02785	COG0222	ribosome binding
KIH16_02790	COG1515	deoxyribonuclease V activity
KIH16_02800	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KIH16_02840	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
KIH16_02845	COG1924	4 iron, 4 sulfur cluster binding
KIH16_02850	COG2801	Transposase and inactivated derivatives
KIH16_02875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KIH16_02955	COG3645	SOS response
KIH16_02975	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KIH16_02980	COG0402	S-adenosylhomocysteine deaminase activity
KIH16_02985	COG2962	Rard protein
KIH16_03010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KIH16_03020	COG1288	antiporter activity
KIH16_03025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KIH16_03030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KIH16_03035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KIH16_03040	COG0243	molybdopterin cofactor binding
KIH16_03060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KIH16_03070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KIH16_03080	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
KIH16_03085	COG3481	metal-dependent phosphohydrolase, HD sub domain
KIH16_03090	COG0564	pseudouridine synthase activity
KIH16_03100	COG1473	amidohydrolase
KIH16_03115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KIH16_03130	COG2801	Transposase and inactivated derivatives
KIH16_03135	COG1802	Transcriptional regulator
KIH16_03145	COG2738	Putative neutral zinc metallopeptidase
KIH16_03155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KIH16_03155	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
KIH16_03160	COG2815	serine threonine protein kinase
KIH16_03160	COG0515	serine threonine protein kinase
KIH16_03165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KIH16_03175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KIH16_03180	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KIH16_03185	COG1058	Belongs to the CinA family
KIH16_03185	COG1546	Belongs to the CinA family
KIH16_03200	COG0446	pyridine nucleotide-disulphide oxidoreductase
KIH16_03230	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KIH16_03235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KIH16_03265	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KIH16_03300	COG3206	protein involved in exopolysaccharide biosynthesis
KIH16_03320	COG2096	Adenosyltransferase
KIH16_03355	COG0473	3-isopropylmalate dehydrogenase activity
KIH16_03360	COG0066	3-isopropylmalate dehydratase activity
KIH16_03365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KIH16_03370	COG0066	3-isopropylmalate dehydratase activity
KIH16_03375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KIH16_03385	COG2186	Transcriptional regulator
KIH16_03410	COG2056	Na+-H+ antiporter family
KIH16_03415	COG0012	GTP binding
KIH16_03435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KIH16_03440	COG0735	belongs to the Fur family
KIH16_03470	COG2081	HI0933 family
KIH16_03495	COG2818	Glycosylase
KIH16_03505	COG1802	Transcriptional regulator
KIH16_03510	COG1757	Na H antiporter
KIH16_03520	COG0390	transport system, permease component
KIH16_03525	COG1132	(ABC) transporter
KIH16_03565	COG1151	hydroxylamine reductase activity
KIH16_03585	COG1418	mRNA catabolic process
KIH16_03590	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KIH16_03615	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KIH16_03620	COG4463	regulation of RNA biosynthetic process
KIH16_03630	COG3869	Catalyzes the specific phosphorylation of arginine residues in
KIH16_03635	COG0542	response to heat
KIH16_03640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KIH16_03645	COG1757	Na H antiporter
KIH16_03655	COG1288	antiporter activity
KIH16_03660	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KIH16_03665	COG1473	amidohydrolase
KIH16_03675	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KIH16_03675	COG1918	ferrous iron import across plasma membrane
KIH16_03770	COG0412	Dienelactone hydrolase
KIH16_03780	COG0501	Belongs to the peptidase M48B family
KIH16_03795	COG4948	Mandelate Racemase Muconate Lactonizing
KIH16_03800	COG0583	DNA-binding transcription factor activity
KIH16_03830	COG2201	protein-glutamate methylesterase activity
KIH16_03840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KIH16_03850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KIH16_03885	COG3180	Ammonia monooxygenase
KIH16_03890	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
KIH16_03895	COG2801	Transposase and inactivated derivatives
KIH16_03920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KIH16_03945	COG1132	(ABC) transporter
KIH16_03955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KIH16_03965	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KIH16_03970	COG3314	Sporulation integral membrane protein YlbJ
KIH16_03975	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KIH16_03980	COG1414	Transcriptional regulator
KIH16_03990	COG0384	phenazine biosynthesis protein PhzF
KIH16_03995	COG1794	racemase activity, acting on amino acids and derivatives
KIH16_04010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KIH16_04015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KIH16_04020	COG2986	histidine ammonia-lyase
KIH16_04025	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KIH16_04040	COG0840	transmembrane signaling receptor activity
KIH16_04045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KIH16_04060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KIH16_04075	COG3391	amine dehydrogenase activity
KIH16_04125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KIH16_04130	COG0156	8-amino-7-oxononanoate synthase activity
KIH16_04135	COG1802	Transcriptional regulator
KIH16_04140	COG1414	Transcriptional regulator
KIH16_04145	COG1288	antiporter activity
KIH16_04150	COG1473	amidohydrolase
KIH16_04155	COG0840	transmembrane signaling receptor activity
KIH16_04160	COG0835	chemotaxis
KIH16_04185	COG0191	fructose-bisphosphate aldolase activity
KIH16_04190	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KIH16_04200	COG1968	undecaprenyl-diphosphatase activity
KIH16_04210	COG0424	maF-like protein
KIH16_04225	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KIH16_04230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KIH16_04235	COG2884	Cell division ATP-binding protein ftsE
KIH16_04240	COG2177	Part of the ABC transporter FtsEX involved in
KIH16_04245	COG0739	heme binding
KIH16_04250	COG0793	Belongs to the peptidase S41A family
KIH16_04260	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KIH16_04270	COG1151	hydroxylamine reductase activity
KIH16_04290	COG1120	ATPase activity
KIH16_04295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KIH16_04335	COG1396	sequence-specific DNA binding
KIH16_04365	COG0419	ATPase involved in DNA repair
KIH16_04380	COG1061	Type III restriction enzyme res subunit
KIH16_04415	COG3728	DNA packaging
KIH16_04420	COG1783	phage Terminase large subunit
KIH16_04515	COG0860	N-Acetylmuramoyl-L-alanine amidase
KIH16_04515	COG2247	cell wall binding repeat
KIH16_04530	COG0582	viral genome integration into host DNA
KIH16_04540	COG2855	membrane
KIH16_04545	COG0583	DNA-binding transcription factor activity
KIH16_04555	COG1966	Carbon starvation protein
KIH16_04560	COG1024	Enoyl-CoA hydratase
KIH16_04575	COG1811	Na channel or pump
KIH16_04580	COG2801	Transposase and inactivated derivatives
KIH16_04590	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
KIH16_04600	COG1473	amidohydrolase
KIH16_04605	COG2801	Transposase and inactivated derivatives
KIH16_04610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KIH16_04615	COG0066	3-isopropylmalate dehydratase activity
KIH16_04625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KIH16_04660	COG1013	pyruvate-flavodoxin oxidoreductase activity
KIH16_04680	COG0446	pyridine nucleotide-disulphide oxidoreductase
KIH16_04690	COG1420	regulation of RNA biosynthetic process
KIH16_04695	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KIH16_04700	COG0443	Heat shock 70 kDa protein
KIH16_04705	COG0484	heat shock protein binding
KIH16_04710	COG2264	protein methyltransferase activity
KIH16_04720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KIH16_04725	COG0443	Heat shock 70 kDa protein
KIH16_04730	COG0484	heat shock protein binding
KIH16_04735	COG0537	adenosine 5'-monophosphoramidase activity
KIH16_04750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KIH16_04760	COG0559	Belongs to the binding-protein-dependent transport system permease family
KIH16_04780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KIH16_04785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KIH16_04800	COG0653	protein targeting
KIH16_04810	COG0018	arginyl-trna synthetase
KIH16_04820	COG0360	Binds together with S18 to 16S ribosomal RNA
KIH16_04825	COG0629	single-stranded DNA binding
KIH16_04830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KIH16_04840	COG0359	binds to the 23S rRNA
KIH16_04845	COG0305	Participates in initiation and elongation during chromosome replication
KIH16_04905	COG1459	type II secretion system
KIH16_04945	COG0010	Belongs to the arginase family
KIH16_04950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KIH16_04955	COG0546	phosphoglycolate phosphatase activity
KIH16_04970	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KIH16_04975	COG1799	cell septum assembly
KIH16_04980	COG3599	regulation of cell shape
KIH16_04985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KIH16_04995	COG1418	mRNA catabolic process
KIH16_05000	COG1692	metallophosphoesterase
KIH16_05005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KIH16_05010	COG0733	neurotransmitter:sodium symporter activity
KIH16_05020	COG3118	belongs to the thioredoxin family
KIH16_05045	COG1473	amidohydrolase
KIH16_05050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KIH16_05070	COG1737	Transcriptional regulator
KIH16_05080	COG1115	amino acid carrier protein
KIH16_05085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KIH16_05090	COG0686	Belongs to the AlaDH PNT family
KIH16_05095	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KIH16_05100	COG0811	peptide transport
KIH16_05120	COG3437	response regulator, receiver
KIH16_05120	COG2770	Histidine kinase
KIH16_05125	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KIH16_05130	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KIH16_05140	COG0006	proline dipeptidase activity
KIH16_05145	COG1773	rubredoxin
KIH16_05150	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KIH16_05175	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KIH16_05175	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KIH16_05175	COG0674	pyruvate-flavodoxin oxidoreductase activity
KIH16_05175	COG1013	pyruvate-flavodoxin oxidoreductase activity
KIH16_05190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KIH16_05195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KIH16_05200	COG1555	photosystem II stabilization
KIH16_05210	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KIH16_05215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KIH16_05220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KIH16_05225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KIH16_05230	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KIH16_05235	COG0154	amidase activity
KIH16_05240	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KIH16_05245	COG0456	acetyltransferase
KIH16_05250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KIH16_05260	COG2199	diguanylate cyclase activity
KIH16_05260	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KIH16_05270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KIH16_05285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KIH16_05290	COG4565	transcriptional regulatory protein
KIH16_05305	COG0737	Belongs to the 5'-nucleotidase family
KIH16_05320	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KIH16_05335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KIH16_05340	COG0784	Response regulator, receiver
KIH16_05340	COG2198	Histidine kinase
KIH16_05340	COG2205	protein histidine kinase activity
KIH16_05350	COG2801	Transposase and inactivated derivatives
KIH16_05365	COG2207	Transcriptional regulator
KIH16_05380	COG0667	Aldo Keto reductase
KIH16_05390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KIH16_05400	COG1162	GTPase activity
KIH16_05425	COG4942	peptidase
KIH16_05450	COG0733	neurotransmitter:sodium symporter activity
KIH16_05465	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
KIH16_05475	COG3845	ABC transporter
KIH16_05485	COG1079	Belongs to the binding-protein-dependent transport system permease family
KIH16_05490	COG4145	pantothenate transmembrane transporter activity
KIH16_05495	COG3924	membrane
KIH16_05500	COG0488	(ABC) transporter
KIH16_05505	COG0778	Nitroreductase
KIH16_05510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KIH16_05515	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KIH16_05520	COG0590	tRNA wobble adenosine to inosine editing
KIH16_05550	COG1937	Protein conserved in bacteria
KIH16_05555	COG0052	Belongs to the universal ribosomal protein uS2 family
KIH16_05560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KIH16_05565	COG0528	UMP kinase activity
KIH16_05570	COG0233	cytoplasmic translational termination
KIH16_05575	COG0549	Belongs to the carbamate kinase family
KIH16_05585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KIH16_05590	COG0210	DNA helicase
KIH16_05595	COG0237	dephospho-CoA kinase activity
KIH16_05600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KIH16_05600	COG0617	tRNA 3'-terminal CCA addition
KIH16_05600	COG3620	sequence-specific DNA binding
KIH16_05605	COG1994	Peptidase M50
KIH16_05610	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KIH16_05615	COG0137	argininosuccinate synthase activity
KIH16_05640	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KIH16_05645	COG2414	aldehyde ferredoxin oxidoreductase
KIH16_05650	COG1704	LemA family
KIH16_05655	COG1797	cobyrinic acid a,c-diamide synthase activity
KIH16_05660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KIH16_05665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KIH16_05695	COG0113	porphobilinogen synthase activity
KIH16_05700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KIH16_05705	COG1492	cobalamin metabolic process
KIH16_05715	COG0181	hydroxymethylbilane synthase activity
KIH16_05720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KIH16_05720	COG1648	precorrin-2 dehydrogenase activity
KIH16_05725	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KIH16_05765	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
KIH16_05780	COG1120	ATPase activity
KIH16_05785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KIH16_05790	COG4822	anaerobic cobalamin biosynthetic process
KIH16_05795	COG1217	gtp-binding protein TYPA
KIH16_05805	COG0683	leucine binding
KIH16_05830	COG1242	4 iron, 4 sulfur cluster binding
KIH16_05840	COG0151	Belongs to the GarS family
KIH16_05845	COG0138	bifunctional purine biosynthesis protein purh
KIH16_05850	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KIH16_05855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KIH16_05860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KIH16_05865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KIH16_05870	COG0047	phosphoribosylformylglycinamidine synthase activity
KIH16_05875	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KIH16_05880	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KIH16_05885	COG0481	GTPase activity
KIH16_05890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KIH16_05905	COG1335	isochorismatase
KIH16_05910	COG1921	L-seryl-tRNASec selenium transferase activity
KIH16_05925	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KIH16_05930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KIH16_05935	COG1141	Ferredoxin
KIH16_05950	COG0180	Tryptophanyl-tRNA synthetase
KIH16_05955	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KIH16_05960	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KIH16_05965	COG1187	pseudouridine synthase activity
KIH16_05970	COG1639	'signal transduction protein
KIH16_05975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KIH16_05985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KIH16_05990	COG1561	YicC-like family, N-terminal region
KIH16_05995	COG2052	Domain of unknown function (DUF370)
KIH16_06000	COG0194	GDP metabolic process
KIH16_06010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KIH16_06015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KIH16_06020	COG1160	GTP binding
KIH16_06030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KIH16_06040	COG2801	Transposase and inactivated derivatives
KIH16_06045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KIH16_06060	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KIH16_06065	COG1323	Belongs to the UPF0348 family
KIH16_06070	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KIH16_06080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KIH16_06090	COG0416	fatty acid biosynthetic process
KIH16_06095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KIH16_06105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KIH16_06115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KIH16_06120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KIH16_06125	COG0571	ribonuclease III activity
KIH16_06130	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KIH16_06135	COG0540	Belongs to the ATCase OTCase family
KIH16_06140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KIH16_06145	COG0543	2 iron, 2 sulfur cluster binding
KIH16_06150	COG0167	dihydroorotate dehydrogenase activity
KIH16_06155	COG0284	orotidine-5'-phosphate decarboxylase activity
KIH16_06160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KIH16_06180	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KIH16_06180	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KIH16_06195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KIH16_06200	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KIH16_06210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KIH16_06225	COG1774	PSP1 C-terminal conserved region
KIH16_06245	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KIH16_06265	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
KIH16_06270	COG0482	sulfurtransferase activity
KIH16_06275	COG1067	ATP-dependent peptidase activity
KIH16_06280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KIH16_06290	COG4496	protein, YerC YecD
KIH16_06295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KIH16_06335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KIH16_06340	COG0556	nucleotide-excision repair
KIH16_06345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KIH16_06350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KIH16_06355	COG2801	Transposase and inactivated derivatives
KIH16_06360	COG2801	Transposase and inactivated derivatives
KIH16_06365	COG2801	Transposase and inactivated derivatives
KIH16_06375	COG0736	holo-[acyl-carrier-protein] synthase activity
KIH16_06380	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KIH16_06380	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KIH16_06385	COG1121	(ABC) transporter
KIH16_06390	COG1214	PFAM Peptidase M22, glycoprotease
KIH16_06400	COG0446	pyridine nucleotide-disulphide oxidoreductase
KIH16_06415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KIH16_06425	COG0674	pyruvate-flavodoxin oxidoreductase activity
KIH16_06425	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KIH16_06430	COG1013	pyruvate-flavodoxin oxidoreductase activity
KIH16_06440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KIH16_06445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KIH16_06460	COG1269	ATP hydrolysis coupled proton transport
KIH16_06465	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KIH16_06475	COG1527	subunit (C
KIH16_06485	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
KIH16_06505	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KIH16_06515	COG2001	Belongs to the MraZ family
KIH16_06520	COG0275	rRNA processing
KIH16_06530	COG0768	penicillin binding
KIH16_06535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KIH16_06540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KIH16_06545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KIH16_06550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KIH16_06555	COG0772	Belongs to the SEDS family
KIH16_06560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KIH16_06565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KIH16_06570	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KIH16_06585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KIH16_06595	COG0303	'Molybdopterin
KIH16_06605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KIH16_06610	COG0315	cyclic pyranopterin monophosphate synthase activity
KIH16_06615	COG0521	Mo-molybdopterin cofactor biosynthetic process
KIH16_06625	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KIH16_06645	COG0126	phosphoglycerate kinase activity
KIH16_06650	COG0149	triose-phosphate isomerase activity
KIH16_06660	COG1316	TRANSCRIPTIONal
KIH16_06665	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KIH16_06670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KIH16_06675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KIH16_06685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KIH16_06695	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KIH16_06705	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KIH16_06715	COG1722	exodeoxyribonuclease VII activity
KIH16_06720	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KIH16_06730	COG1674	ftsk spoiiie
KIH16_06735	COG0312	modulator of DNA gyrase
KIH16_06740	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KIH16_06745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KIH16_06750	COG2986	histidine ammonia-lyase
KIH16_06760	COG2078	PFAM AMMECR1 domain protein
KIH16_06760	COG3885	ferrous iron binding
KIH16_06765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KIH16_06770	COG2385	sporulation resulting in formation of a cellular spore
KIH16_06780	COG2255	four-way junction helicase activity
KIH16_06785	COG0632	four-way junction helicase activity
KIH16_06790	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KIH16_06795	COG0217	transcriptional regulatory protein
KIH16_06800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KIH16_06805	COG0864	Transcriptional regulator
KIH16_06810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KIH16_06820	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KIH16_06825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KIH16_06835	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KIH16_06840	COG4589	Belongs to the CDS family
KIH16_06845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KIH16_06850	COG1573	uracil-dna glycosylase
KIH16_06855	COG2255	four-way junction helicase activity
KIH16_06860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KIH16_06865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KIH16_06870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KIH16_06875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KIH16_06880	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
KIH16_06895	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KIH16_06915	COG0673	inositol 2-dehydrogenase activity
KIH16_06925	COG0285	dihydrofolate synthase activity
KIH16_06930	COG0525	valine-tRNA ligase activity
KIH16_06935	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KIH16_06940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KIH16_06945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KIH16_06950	COG0740	serine-type endopeptidase activity
KIH16_06955	COG0544	peptidyl-prolyl cis-trans isomerase activity
KIH16_06970	COG0668	transmembrane transport
KIH16_07015	COG4120	Belongs to the binding-protein-dependent transport system permease family
KIH16_07020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KIH16_07020	COG1116	anion transmembrane transporter activity
KIH16_07030	COG1293	RNA-binding protein homologous to eukaryotic snRNP
KIH16_07035	COG0564	pseudouridine synthase activity
KIH16_07040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KIH16_07060	COG0196	riboflavin kinase activity
KIH16_07065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KIH16_07070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KIH16_07075	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KIH16_07085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KIH16_07100	COG0195	Participates in both transcription termination and antitermination
KIH16_07105	COG0779	Required for maturation of 30S ribosomal subunits
KIH16_07110	COG0516	GMP reductase activity
KIH16_07110	COG0517	IMP dehydrogenase activity
KIH16_07115	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KIH16_07120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KIH16_07120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KIH16_07125	COG4956	integral membrane protein (PIN domain superfamily)
KIH16_07130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KIH16_07135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KIH16_07140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KIH16_07155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KIH16_07160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KIH16_07165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KIH16_07165	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KIH16_07175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KIH16_07175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KIH16_07180	COG0322	excinuclease ABC activity
KIH16_07185	COG0215	cysteine-tRNA ligase activity
KIH16_07195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KIH16_07200	COG0840	transmembrane signaling receptor activity
KIH16_07205	COG4968	Prepilin-type N-terminal cleavage methylation domain
KIH16_07210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KIH16_07215	COG0720	synthase
KIH16_07230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KIH16_07235	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KIH16_07265	COG0494	nUDIX hydrolase
KIH16_07295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KIH16_07305	COG0539	negative regulation of cytoplasmic translation
KIH16_07310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KIH16_07315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KIH16_07320	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KIH16_07325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KIH16_07330	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KIH16_07335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KIH16_07340	COG0402	S-adenosylhomocysteine deaminase activity
KIH16_07345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KIH16_07350	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KIH16_07355	COG1570	exodeoxyribonuclease VII activity
KIH16_07360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KIH16_07380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KIH16_07440	COG1459	type II secretion system
KIH16_07450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KIH16_07480	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KIH16_07485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KIH16_07485	COG0574	Belongs to the PEP-utilizing enzyme family
KIH16_07490	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KIH16_07495	COG0751	glycine-tRNA ligase activity
KIH16_07500	COG0752	glycyl-tRNA synthetase alpha subunit
KIH16_07510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KIH16_07515	COG0295	cytidine deaminase activity
KIH16_07520	COG4536	flavin adenine dinucleotide binding
KIH16_07525	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KIH16_07530	COG1480	7TM receptor with intracellular HD hydrolase
KIH16_07550	COG3956	TIGRFAM MazG family protein
KIH16_07555	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KIH16_07565	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KIH16_07570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KIH16_07575	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KIH16_07585	COG0735	belongs to the Fur family
KIH16_07600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KIH16_07605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KIH16_07610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KIH16_07620	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KIH16_07630	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KIH16_07635	COG0494	nUDIX hydrolase
KIH16_07655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KIH16_07660	COG0501	Belongs to the peptidase M48B family
KIH16_07680	COG0517	IMP dehydrogenase activity
KIH16_07680	COG0617	tRNA 3'-terminal CCA addition
KIH16_07680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KIH16_07685	COG1105	Belongs to the carbohydrate kinase PfkB family
KIH16_07695	COG2890	protein-(glutamine-N5) methyltransferase activity
KIH16_07700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KIH16_07705	COG3872	metal-dependent enzyme
KIH16_07710	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KIH16_07725	COG2358	TRAP transporter, solute receptor (TAXI family
KIH16_07760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KIH16_07765	COG0252	asparaginase activity
KIH16_07790	COG3260	NADH ubiquinone oxidoreductase 20
KIH16_07800	COG0651	ATP synthesis coupled electron transport
KIH16_07845	COG1193	negative regulation of DNA recombination
KIH16_07865	COG0072	phenylalanine-tRNA ligase activity
KIH16_07870	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KIH16_07875	COG0569	domain protein
KIH16_07880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KIH16_07885	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KIH16_07895	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KIH16_07900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KIH16_07905	COG0733	neurotransmitter:sodium symporter activity
KIH16_07915	COG1185	polyribonucleotide nucleotidyltransferase activity
KIH16_07920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KIH16_07925	COG0745	RESPONSE REGULATOR receiver
KIH16_07945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KIH16_07950	COG3852	Histidine kinase
KIH16_07955	COG2204	response regulator
KIH16_07965	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
KIH16_07970	COG1914	H( )-stimulated, divalent metal cation uptake system
KIH16_07975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KIH16_07980	COG1984	allophanate hydrolase subunit 2
KIH16_07985	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KIH16_07990	COG4336	lyase activity
KIH16_07995	COG1683	Conserved Protein
KIH16_08010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KIH16_08015	COG1027	Aspartate ammonia-lyase
KIH16_08020	COG0745	RESPONSE REGULATOR receiver
KIH16_08025	COG2198	Histidine kinase
KIH16_08025	COG0784	Response regulator, receiver
KIH16_08025	COG2205	protein histidine kinase activity
KIH16_08035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KIH16_08060	COG1598	PFAM Uncharacterised protein family UPF0150
KIH16_08070	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KIH16_08110	COG0281	malic enzyme
KIH16_08135	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KIH16_08140	COG2197	response regulator
KIH16_08145	COG0037	tRNA processing
KIH16_08160	COG0719	Fe-S assembly protein
KIH16_08165	COG0396	ATPase activity
KIH16_08170	COG0166	Belongs to the GPI family
KIH16_08175	COG0543	2 iron, 2 sulfur cluster binding
KIH16_08190	COG2326	polyphosphate kinase activity
KIH16_08195	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KIH16_08200	COG2801	Transposase and inactivated derivatives
KIH16_08210	COG0235	Class ii aldolase
KIH16_08215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KIH16_08215	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KIH16_08230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KIH16_08245	COG1830	Aldolase
KIH16_08265	COG2084	Dehydrogenase
KIH16_08270	COG1032	radical SAM domain protein
KIH16_08275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KIH16_08290	COG0183	Belongs to the thiolase family
KIH16_08295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KIH16_08300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KIH16_08310	COG2358	TRAP transporter, solute receptor (TAXI family
KIH16_08315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KIH16_08340	COG2201	protein-glutamate methylesterase activity
KIH16_08345	COG2801	Transposase and inactivated derivatives
KIH16_08350	COG2201	protein-glutamate methylesterase activity
KIH16_08365	COG2119	membrane
KIH16_08370	COG0628	permease
KIH16_08395	COG1847	R3H domain protein
KIH16_08400	COG0706	membrane insertase activity
KIH16_08405	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KIH16_08410	COG0594	ribonuclease P activity
KIH16_08415	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KIH16_08420	COG1199	ATP-dependent helicase activity
KIH16_08425	COG0268	Binds directly to 16S ribosomal RNA
KIH16_08435	COG0495	leucyl-tRNA aminoacylation
KIH16_08440	COG0330	HflC and HflK could
KIH16_08450	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KIH16_08455	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KIH16_08460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KIH16_08465	COG0131	Imidazoleglycerol-phosphate dehydratase
KIH16_08470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KIH16_08475	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KIH16_08480	COG0107	imidazoleglycerol-phosphate synthase activity
KIH16_08495	COG1288	antiporter activity
KIH16_08505	COG0613	PHP domain protein
KIH16_08545	COG1609	Transcriptional regulator
KIH16_08565	COG4177	L-phenylalanine transmembrane transporter activity
KIH16_08600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KIH16_08665	COG2089	acid synthase
KIH16_08670	COG1086	Polysaccharide biosynthesis protein
KIH16_08675	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
KIH16_08740	COG1040	competence protein
KIH16_08745	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KIH16_08750	COG0454	-acetyltransferase
KIH16_08760	COG4372	Transposase
KIH16_08780	COG1706	bacterial-type flagellum-dependent cell motility
KIH16_08785	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KIH16_08800	COG4786	Flagellar basal body rod
KIH16_08805	COG1077	Cell shape determining protein MreB Mrl
KIH16_08810	COG0101	tRNA pseudouridine synthase activity
KIH16_08815	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KIH16_08820	COG1122	ATPase activity
KIH16_08825	COG1122	ATPase activity
KIH16_08830	COG0203	ribosomal protein L17
KIH16_08835	COG0202	RNA polymerase activity
KIH16_08840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KIH16_08845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KIH16_08850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KIH16_08860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KIH16_08870	COG0563	adenylate kinase activity
KIH16_08875	COG0201	protein transport
KIH16_08880	COG0200	Binds to the 23S rRNA
KIH16_08885	COG1841	ribosomal large subunit assembly
KIH16_08890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KIH16_08895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KIH16_08900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KIH16_08905	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KIH16_08910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KIH16_08920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KIH16_08925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KIH16_08930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KIH16_08940	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KIH16_08945	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KIH16_08950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KIH16_08955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KIH16_08960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KIH16_08965	COG0089	rRNA binding
KIH16_08970	COG0088	Forms part of the polypeptide exit tunnel
KIH16_08975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KIH16_08980	COG0051	transcription antitermination factor activity, RNA binding
KIH16_08990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KIH16_08995	COG0049	tRNA binding
KIH16_09000	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KIH16_09005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KIH16_09005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KIH16_09010	COG0085	RNA polymerase activity
KIH16_09025	COG0009	L-threonylcarbamoyladenylate synthase
KIH16_09030	COG0343	queuine tRNA-ribosyltransferase activity
KIH16_09035	COG0084	hydrolase, TatD family'
KIH16_09060	COG1192	Involved in chromosome partitioning
KIH16_09070	COG1196	nuclear chromosome segregation
KIH16_09090	COG0772	Belongs to the SEDS family
KIH16_09095	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KIH16_09100	COG2894	cell division
KIH16_09105	COG0850	regulation of cytokinetic process
KIH16_09125	COG1077	Cell shape determining protein MreB Mrl
KIH16_09130	COG2003	Belongs to the UPF0758 family
KIH16_09135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KIH16_09140	COG1490	D-aminoacyl-tRNA deacylase activity
KIH16_09145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KIH16_09150	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KIH16_09150	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KIH16_09165	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KIH16_09170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KIH16_09175	COG1862	Preprotein translocase
KIH16_09180	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KIH16_09185	COG0148	phosphopyruvate hydratase activity
KIH16_09190	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KIH16_09200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KIH16_09205	COG0358	DNA primase activity
KIH16_09210	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KIH16_09220	COG0628	permease
KIH16_09240	COG0519	Catalyzes the synthesis of GMP from XMP
KIH16_09240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KIH16_09245	COG0459	protein refolding
KIH16_09250	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KIH16_09255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KIH16_09265	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KIH16_09290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KIH16_09300	COG0083	homoserine kinase activity
KIH16_09305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KIH16_09310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KIH16_09315	COG1181	Belongs to the D-alanine--D-alanine ligase family
KIH16_09345	COG0504	CTP synthase activity
KIH16_09350	COG0739	heme binding
KIH16_09355	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KIH16_09360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KIH16_09385	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KIH16_09390	COG0546	phosphoglycolate phosphatase activity
KIH16_09410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KIH16_09415	COG4191	Histidine kinase
KIH16_09415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KIH16_09425	COG0058	SHG alpha-glucan phosphorylase activity
KIH16_09430	COG0297	glycogen (starch) synthase activity
KIH16_09435	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KIH16_09450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KIH16_09455	COG1454	alcohol dehydrogenase
KIH16_09460	COG1519	Transferase
KIH16_09470	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KIH16_09475	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KIH16_09480	COG1663	tetraacyldisaccharide 4'-kinase activity
KIH16_09485	COG1132	(ABC) transporter
KIH16_09495	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KIH16_09510	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KIH16_09515	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KIH16_09520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KIH16_09525	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KIH16_09530	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KIH16_09550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KIH16_09555	COG0406	alpha-ribazole phosphatase activity
KIH16_09575	COG0165	Argininosuccinate lyase
KIH16_09580	COG0248	Ppx GppA phosphatase
KIH16_09615	COG1191	sigma factor activity
KIH16_09625	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
KIH16_09630	COG1776	CheC inhibitor of MCP methylation
KIH16_09635	COG2198	Histidine kinase
KIH16_09635	COG0643	Histidine kinase
KIH16_09640	COG2201	protein-glutamate methylesterase activity
KIH16_09655	COG1419	protein localization to endoplasmic reticulum
KIH16_09660	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KIH16_09665	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KIH16_09670	COG1684	flagellar biosynthetic protein fliR
KIH16_09675	COG1987	bacterial-type flagellum assembly
KIH16_09680	COG1338	Plays a role in the flagellum-specific transport system
KIH16_09690	COG2201	protein-glutamate methylesterase activity
KIH16_09695	COG1776	CheC inhibitor of MCP methylation
KIH16_09695	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KIH16_09700	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KIH16_09750	COG0741	lytic transglycosylase activity
KIH16_09760	COG1157	protein secretion by the type III secretion system
KIH16_09770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KIH16_09775	COG1766	The M ring may be actively involved in energy transduction
KIH16_09780	COG1677	Flagellar hook-basal body complex protein FliE
KIH16_09800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KIH16_09805	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KIH16_09815	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KIH16_09820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KIH16_09840	COG0792	nuclease activity
KIH16_09860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KIH16_09865	COG0681	Belongs to the peptidase S26 family
KIH16_09885	COG0824	Thioesterase
KIH16_09905	COG0582	viral genome integration into host DNA
KIH16_10000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KIH16_10005	COG0601	transmembrane transport
KIH16_10010	COG0747	negative chemotaxis
KIH16_10020	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
KIH16_10035	COG1691	(AIR) carboxylase
KIH16_10040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KIH16_10050	COG0189	ligase activity
KIH16_10055	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
KIH16_10065	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
KIH16_10090	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KIH16_10090	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KIH16_10095	COG1229	Formylmethanofuran dehydrogenase subunit A
KIH16_10115	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KIH16_10125	COG0531	amino acid
KIH16_10135	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KIH16_10135	COG0674	pyruvate-flavodoxin oxidoreductase activity
KIH16_10135	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KIH16_10135	COG1013	pyruvate-flavodoxin oxidoreductase activity
KIH16_10140	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
KIH16_10145	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
KIH16_10180	COG1394	ATPase activity, coupled to movement of substances
KIH16_10185	COG0697	spore germination
KIH16_10205	COG0346	lactoylglutathione lyase activity
KIH16_10220	COG0303	'Molybdopterin
KIH16_10235	COG2226	methyltransferase
KIH16_10245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KIH16_10250	COG1120	ATPase activity
KIH16_10255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KIH16_10290	COG0335	large ribosomal subunit rRNA binding
KIH16_10295	COG0336	Belongs to the RNA methyltransferase TrmD family
KIH16_10300	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KIH16_10310	COG0228	four-way junction DNA binding
KIH16_10315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KIH16_10320	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
KIH16_10335	COG1902	pentaerythritol trinitrate reductase activity
KIH16_10340	COG1902	pentaerythritol trinitrate reductase activity
KIH16_10350	COG2076	Multidrug Resistance protein
KIH16_10360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KIH16_10370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KIH16_10370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KIH16_10380	COG0726	polysaccharide deacetylase
KIH16_10400	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KIH16_10405	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KIH16_10410	COG0124	histidyl-tRNA synthetase
KIH16_10415	COG2359	stage V sporulation protein S
KIH16_10425	COG3123	guanosine phosphorylase activity
KIH16_10430	COG1376	ErfK ybiS ycfS ynhG family protein
KIH16_10435	COG1126	abc transporter atp-binding protein
KIH16_10440	COG0765	amino acid transport
KIH16_10465	COG0446	pyridine nucleotide-disulphide oxidoreductase
KIH16_10475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KIH16_10495	COG1129	ABC transporter
KIH16_10500	COG1609	Transcriptional regulator
KIH16_10505	COG1803	Methylglyoxal synthase
KIH16_10510	COG0697	spore germination
KIH16_10525	COG2212	antiporter activity
KIH16_10530	COG1320	monovalent cation:proton antiporter activity
KIH16_10535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KIH16_10535	COG2111	Na H antiporter
KIH16_10545	COG0713	ATP synthesis coupled electron transport
KIH16_10550	COG0651	ATP synthesis coupled electron transport
KIH16_10565	COG0330	HflC and HflK could
KIH16_10580	COG1785	Belongs to the alkaline phosphatase family
KIH16_10590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KIH16_10595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KIH16_10600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KIH16_10605	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KIH16_10615	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KIH16_10620	COG2801	Transposase and inactivated derivatives
KIH16_10625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KIH16_10650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KIH16_10650	COG4651	solute:proton antiporter activity
KIH16_10665	COG0159	tryptophan synthase activity
KIH16_10675	COG0135	phosphoribosylanthranilate isomerase activity
KIH16_10680	COG0134	indole-3-glycerol-phosphate synthase activity
KIH16_10685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KIH16_10690	COG0512	Glutamine amidotransferase of anthranilate synthase
KIH16_10690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KIH16_10695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KIH16_10710	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KIH16_10725	COG3459	Glycosyltransferase 36 associated
KIH16_10780	COG1111	helicase
KIH16_10780	COG1205	dead DEAH box helicase
KIH16_10785	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KIH16_10805	COG0833	amino acid
KIH16_10810	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KIH16_10815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KIH16_10820	COG0786	glutamate:sodium symporter activity
KIH16_10855	COG0514	ATP-dependent DNA helicase (RecQ)
KIH16_10860	COG1115	amino acid carrier protein
KIH16_10880	COG1802	Transcriptional regulator
KIH16_10890	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KIH16_10890	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KIH16_10895	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KIH16_10895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KIH16_10935	COG1757	Na H antiporter
KIH16_10940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KIH16_10950	COG0531	amino acid
KIH16_10955	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KIH16_10960	COG0371	Dehydrogenase
KIH16_10970	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KIH16_10970	COG3608	succinylglutamate desuccinylase aspartoacylase
KIH16_10990	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KIH16_11000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KIH16_11010	COG2358	TRAP transporter, solute receptor (TAXI family
KIH16_11075	COG0577	efflux transmembrane transporter activity
KIH16_11075	COG1136	(ABC) transporter
KIH16_11090	COG0534	Mate efflux family protein
KIH16_11115	COG2801	Transposase and inactivated derivatives
KIH16_11120	COG2801	Transposase and inactivated derivatives
KIH16_11175	COG0436	Aminotransferase
KIH16_11185	COG0800	Aldolase
KIH16_11190	COG1414	Transcriptional regulator
KIH16_11210	COG0531	amino acid
KIH16_11230	COG3620	sequence-specific DNA binding
KIH16_11250	COG0673	inositol 2-dehydrogenase activity
KIH16_11285	COG3039	Transposase
KIH16_11300	COG3328	transposase activity
KIH16_11400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KIH16_11410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KIH16_11420	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KIH16_11445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KIH16_11500	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KIH16_11505	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KIH16_11520	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KIH16_11545	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KIH16_11550	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KIH16_11555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KIH16_11560	COG1120	ATPase activity
KIH16_11570	COG1918	ferrous iron import across plasma membrane
KIH16_11570	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KIH16_11585	COG2201	protein-glutamate methylesterase activity
KIH16_11590	COG0725	ABC transporter, periplasmic molybdate-binding protein
KIH16_11595	COG3842	ATPase activity
KIH16_11600	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KIH16_11610	COG4662	Binding-protein-dependent transport system inner membrane component
KIH16_11620	COG2998	abc-type tungstate transport system, permease component
KIH16_11625	COG0528	UMP kinase activity
KIH16_11640	COG1012	belongs to the aldehyde dehydrogenase family
KIH16_11660	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
KIH16_11675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KIH16_11680	COG1205	dead DEAH box helicase
KIH16_11680	COG1111	helicase
KIH16_11695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KIH16_11695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KIH16_11700	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KIH16_11710	COG4608	Belongs to the ABC transporter superfamily
KIH16_11715	COG0444	Belongs to the ABC transporter superfamily
KIH16_11720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KIH16_11725	COG0601	transmembrane transport
KIH16_11730	COG0747	negative chemotaxis
KIH16_11740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KIH16_11745	COG2199	diguanylate cyclase activity
KIH16_11750	COG4187	Peptidase family M20/M25/M40
KIH16_11760	COG2848	UPF0210 protein
KIH16_11770	COG3314	Sporulation integral membrane protein YlbJ
KIH16_11775	COG3875	lactate racemase activity
KIH16_11780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KIH16_11785	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KIH16_11795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KIH16_11800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KIH16_11810	COG0251	oxidation-reduction process
KIH16_11815	COG0733	neurotransmitter:sodium symporter activity
KIH16_11825	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KIH16_11835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KIH16_11840	COG2045	Belongs to the ComB family
KIH16_11855	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KIH16_11860	COG1410	methionine synthase
KIH16_11860	COG0646	methionine synthase
KIH16_11880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KIH16_11900	COG0438	transferase activity, transferring glycosyl groups
KIH16_11905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KIH16_11905	COG0561	phosphatase activity
KIH16_11915	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KIH16_11915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KIH16_11920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KIH16_11920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KIH16_11925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KIH16_11930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KIH16_11935	COG1802	Transcriptional regulator
KIH16_11940	COG2086	electron transfer activity
KIH16_11945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KIH16_11950	COG0277	FAD linked oxidase domain protein
KIH16_11965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KIH16_11990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KIH16_12000	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KIH16_12005	COG1882	Formate acetyltransferase
KIH16_12025	COG1882	Formate acetyltransferase
KIH16_12035	COG2195	Cleaves the N-terminal amino acid of tripeptides
KIH16_12040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KIH16_12045	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
KIH16_12050	COG4656	Part of a membrane complex involved in electron transport
KIH16_12065	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
KIH16_12080	COG4820	ethanolamine utilization protein (EutJ)
KIH16_12135	COG4810	utilization protein
KIH16_12145	COG3275	phosphorelay sensor kinase activity
KIH16_12150	COG1454	alcohol dehydrogenase
KIH16_12170	COG2986	histidine ammonia-lyase
KIH16_12180	COG0477	Major facilitator Superfamily
KIH16_12185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KIH16_12190	COG3290	protein histidine kinase activity
KIH16_12190	COG3829	transcription factor binding
KIH16_12210	COG3290	protein histidine kinase activity
KIH16_12210	COG3829	transcription factor binding
KIH16_12215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KIH16_12240	COG0179	Fumarylacetoacetate (FAA) hydrolase
KIH16_12250	COG1196	nuclear chromosome segregation
KIH16_12255	COG3437	response regulator, receiver
KIH16_12255	COG0784	Response regulator, receiver
KIH16_12260	COG0442	prolyl-tRNA aminoacylation
KIH16_12275	COG3191	aminopeptidase activity
KIH16_12315	COG2086	electron transfer activity
KIH16_12320	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KIH16_12325	COG0277	FAD linked oxidase domain protein
KIH16_12330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KIH16_12335	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KIH16_12335	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KIH16_12340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KIH16_12340	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KIH16_12350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KIH16_12355	COG3039	Transposase
KIH16_12370	COG5012	cobalamin binding
KIH16_12385	COG1757	Na H antiporter
KIH16_12405	COG0523	cobalamin synthesis protein
KIH16_12410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KIH16_12415	COG1116	anion transmembrane transporter activity
KIH16_12420	COG4521	taurine ABC transporter
KIH16_12430	COG0446	pyridine nucleotide-disulphide oxidoreductase
KIH16_12435	COG2186	Transcriptional regulator
KIH16_12440	COG0579	oxidoreductase
KIH16_12445	COG0446	pyridine nucleotide-disulphide oxidoreductase
KIH16_12455	COG1234	tRNA 3'-trailer cleavage
KIH16_12460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KIH16_12485	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KIH16_12495	COG0716	FMN binding
KIH16_12510	COG0822	iron-sulfur transferase activity
KIH16_12520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KIH16_12525	COG1760	l-serine dehydratase
KIH16_12530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KIH16_12535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KIH16_12545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KIH16_12555	COG2423	ornithine cyclodeaminase activity
KIH16_12565	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KIH16_12565	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KIH16_12575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KIH16_12590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KIH16_12610	COG1827	regulation of RNA biosynthetic process
KIH16_12635	COG0028	Belongs to the TPP enzyme family
KIH16_12645	COG3069	C4-dicarboxylate transmembrane transporter activity
KIH16_12690	COG2936	dipeptidyl-peptidase activity
KIH16_12700	COG1802	Transcriptional regulator
KIH16_12720	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KIH16_12720	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KIH16_12740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KIH16_12755	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KIH16_12765	COG2204	response regulator
KIH16_12815	COG1353	crispr-associated protein
KIH16_12825	COG1337	RAMP superfamily
KIH16_12855	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KIH16_12880	COG1518	maintenance of DNA repeat elements
KIH16_12890	COG2379	hydroxypyruvate reductase
KIH16_12895	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KIH16_12905	COG1473	amidohydrolase
KIH16_12920	COG1131	(ABC) transporter
KIH16_12935	COG2731	YhcH YjgK YiaL family protein
KIH16_12940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KIH16_12960	COG2205	protein histidine kinase activity
KIH16_12960	COG0784	Response regulator, receiver
KIH16_12960	COG5002	protein histidine kinase activity
KIH16_12965	COG0584	glycerophosphoryl diester phosphodiesterase
KIH16_12970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KIH16_12975	COG3842	ATPase activity
KIH16_12980	COG1176	ABC-type spermidine putrescine transport system, permease component I
KIH16_12985	COG1177	transmembrane transport
KIH16_12995	COG3437	response regulator, receiver
KIH16_12995	COG2770	Histidine kinase
KIH16_13010	COG2186	Transcriptional regulator
KIH16_13015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KIH16_13025	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KIH16_13025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KIH16_13030	COG0129	dihydroxy-acid dehydratase activity
KIH16_13045	COG4895	conserved protein (DUF2196)
KIH16_13055	COG0405	Gamma-glutamyltransferase
KIH16_13060	COG0835	chemotaxis
KIH16_13065	COG0840	transmembrane signaling receptor activity
KIH16_13085	COG4942	peptidase
KIH16_13115	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KIH16_13115	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KIH16_13120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KIH16_13120	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KIH16_13125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KIH16_13140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KIH16_13145	COG1802	Transcriptional regulator
KIH16_13150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KIH16_13165	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KIH16_13170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KIH16_13180	COG0071	Belongs to the small heat shock protein (HSP20) family
KIH16_13200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KIH16_13210	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KIH16_13210	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KIH16_13230	COG0640	Transcriptional regulator
KIH16_13245	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KIH16_13250	COG1802	Transcriptional regulator
KIH16_13260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KIH16_13370	COG0352	thiamine-phosphate diphosphorylase activity
KIH16_13380	COG0351	phosphomethylpyrimidine kinase
KIH16_13385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KIH16_13395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KIH16_13400	COG1116	anion transmembrane transporter activity
KIH16_13430	COG0436	Aminotransferase
KIH16_13440	COG2801	Transposase and inactivated derivatives
KIH16_13445	COG1408	metallophosphoesterase
KIH16_13455	COG1477	protein flavinylation
KIH16_13470	COG2878	Part of a membrane complex involved in electron transport
KIH16_13475	COG4657	Part of a membrane complex involved in electron transport
KIH16_13480	COG4660	Part of a membrane complex involved in electron transport
KIH16_13485	COG4659	FMN binding
KIH16_13490	COG4658	electron transport chain
KIH16_13495	COG4656	Part of a membrane complex involved in electron transport
KIH16_13500	COG0006	proline dipeptidase activity
KIH16_13510	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KIH16_13535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KIH16_13545	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KIH16_13545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KIH16_13550	COG4187	Peptidase family M20/M25/M40
KIH16_13595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KIH16_13645	COG0840	transmembrane signaling receptor activity
KIH16_13655	COG0840	transmembrane signaling receptor activity
KIH16_13660	COG2183	response to ionizing radiation
KIH16_13665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KIH16_13670	COG0651	ATP synthesis coupled electron transport
KIH16_13675	COG0650	Formate hydrogenlyase subunit 4
KIH16_13685	COG0651	ATP synthesis coupled electron transport
KIH16_13695	COG3260	NADH ubiquinone oxidoreductase 20
KIH16_13720	COG0668	transmembrane transport
KIH16_13730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KIH16_13735	COG0573	inorganic phosphate transmembrane transporter activity
KIH16_13740	COG0581	inorganic phosphate transmembrane transporter activity
KIH16_13745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KIH16_13750	COG0704	Plays a role in the regulation of phosphate uptake
KIH16_13755	COG0745	RESPONSE REGULATOR receiver
KIH16_13760	COG5002	protein histidine kinase activity
KIH16_13780	COG0840	transmembrane signaling receptor activity
KIH16_13805	COG2894	cell division
KIH16_13820	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KIH16_13825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KIH16_13830	COG1120	ATPase activity
KIH16_13835	COG0731	radical SAM domain protein
KIH16_13835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KIH16_13880	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KIH16_13885	COG1193	negative regulation of DNA recombination
KIH16_13890	COG0148	phosphopyruvate hydratase activity
KIH16_13905	COG0714	Associated with various cellular activities
KIH16_13925	COG1993	acr, cog1993
KIH16_13930	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KIH16_13940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KIH16_13960	COG0133	tryptophan synthase activity
KIH16_13980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KIH16_13985	COG0318	PFAM AMP-dependent synthetase and ligase
KIH16_14015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KIH16_14020	COG1125	glycine betaine transport
KIH16_14020	COG0517	IMP dehydrogenase activity
KIH16_14035	COG2414	aldehyde ferredoxin oxidoreductase
KIH16_14040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KIH16_14050	COG2508	Transcriptional regulator
KIH16_14055	COG1288	antiporter activity
KIH16_14080	COG2190	(PTS) system
KIH16_14090	COG0363	glucosamine-6-phosphate deaminase activity
KIH16_14100	COG1263	PTS System
KIH16_14100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KIH16_14100	COG2190	(PTS) system
KIH16_14105	COG2188	Transcriptional regulator
KIH16_14110	COG1309	transcriptional regulator
KIH16_14115	COG4953	penicillin-binding protein 1C
KIH16_14135	COG2197	response regulator
KIH16_14165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)