locus-tag	class	description
Sfum_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Sfum_0002	COG0776	regulation of translation
Sfum_0003	COG0720	synthase
Sfum_0005	COG0501	Belongs to the peptidase M48B family
Sfum_0006	COG0517	IMP dehydrogenase activity
Sfum_0006	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Sfum_0007	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Sfum_0008	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Sfum_0009	COG0505	Belongs to the CarA family
Sfum_0010	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Sfum_0011	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Sfum_0016	COG1013	pyruvate-flavodoxin oxidoreductase activity
Sfum_0017	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Sfum_0017	COG0674	pyruvate-flavodoxin oxidoreductase activity
Sfum_0020	COG1067	ATP-dependent peptidase activity
Sfum_0022	COG0011	TIGRFAM Protein of
Sfum_0030	COG3383	formate dehydrogenase (NAD+) activity
Sfum_0031	COG3383	formate dehydrogenase (NAD+) activity
Sfum_0034	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Sfum_0035	COG0243	molybdopterin cofactor binding
Sfum_0035	COG3383	formate dehydrogenase (NAD+) activity
Sfum_0041	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Sfum_0042	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Sfum_0044	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Sfum_0047	COG0549	Belongs to the carbamate kinase family
Sfum_0049	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Sfum_0050	COG0741	lytic transglycosylase activity
Sfum_0051	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Sfum_0053	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Sfum_0054	COG0436	Aminotransferase
Sfum_0055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Sfum_0056	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Sfum_0057	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Sfum_0060	COG0165	Argininosuccinate lyase
Sfum_0061	COG0137	argininosuccinate synthase activity
Sfum_0062	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Sfum_0063	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Sfum_0064	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Sfum_0066	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Sfum_0067	COG4974	Belongs to the 'phage' integrase family
Sfum_0068	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Sfum_0070	COG0521	Mo-molybdopterin cofactor biosynthetic process
Sfum_0076	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Sfum_0077	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Sfum_0078	COG0148	phosphopyruvate hydratase activity
Sfum_0079	COG0247	lactate metabolic process
Sfum_0081	COG1556	Lactate utilization protein
Sfum_0084	COG0724	RNA recognition motif
Sfum_0094	COG0477	Major facilitator Superfamily
Sfum_0098	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Sfum_0099	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Sfum_0100	COG0740	serine-type endopeptidase activity
Sfum_0101	COG0544	peptidyl-prolyl cis-trans isomerase activity
Sfum_0102	COG2165	general secretion pathway protein
Sfum_0103	COG1242	4 iron, 4 sulfur cluster binding
Sfum_0104	COG0445	tRNA wobble uridine modification
Sfum_0106	COG2086	electron transfer activity
Sfum_0107	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Sfum_0108	COG0318	PFAM AMP-dependent synthetase and ligase
Sfum_0111	COG2264	protein methyltransferase activity
Sfum_0112	COG1028	Short-chain dehydrogenase reductase Sdr
Sfum_0113	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Sfum_0114	COG1013	pyruvate-flavodoxin oxidoreductase activity
Sfum_0115	COG0674	pyruvate-flavodoxin oxidoreductase activity
Sfum_0117	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Sfum_0119	COG4191	Histidine kinase
Sfum_0120	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Sfum_0121	COG0459	protein refolding
Sfum_0122	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Sfum_0123	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Sfum_0128	COG1215	transferase activity, transferring glycosyl groups
Sfum_0132	COG0109	protoheme IX farnesyltransferase activity
Sfum_0143	COG1028	Short-chain dehydrogenase reductase Sdr
Sfum_0147	COG0242	peptide deformylase activity
Sfum_0148	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Sfum_0150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Sfum_0150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Sfum_0151	COG2226	methyltransferase
Sfum_0154	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sfum_0154	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sfum_0155	COG1774	PSP1 C-terminal conserved region
Sfum_0157	COG3481	metal-dependent phosphohydrolase, HD sub domain
Sfum_0161	COG0237	dephospho-CoA kinase activity
Sfum_0163	COG1372	Participates in initiation and elongation during chromosome replication
Sfum_0163	COG0719	Fe-S assembly protein
Sfum_0164	COG0396	ATPase activity
Sfum_0166	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Sfum_0167	COG0482	sulfurtransferase activity
Sfum_0168	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Sfum_0169	COG0006	proline dipeptidase activity
Sfum_0173	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Sfum_0174	COG1053	succinate dehydrogenase
Sfum_0185	COG0330	HflC and HflK could
Sfum_0186	COG0463	Glycosyl transferase, family 2
Sfum_0187	COG2204	response regulator
Sfum_0188	COG0795	lipopolysaccharide-transporting ATPase activity
Sfum_0190	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Sfum_0192	COG0525	valine-tRNA ligase activity
Sfum_0194	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Sfum_0196	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Sfum_0197	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Sfum_0200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sfum_0201	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sfum_0202	COG0649	NAD binding
Sfum_0203	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Sfum_0204	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sfum_0206	COG0713	ATP synthesis coupled electron transport
Sfum_0207	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Sfum_0208	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sfum_0209	COG1007	ATP synthesis coupled electron transport
Sfum_0212	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Sfum_0212	COG0758	DNA mediated transformation
Sfum_0213	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Sfum_0214	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Sfum_0215	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Sfum_0226	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Sfum_0227	COG2816	NAD+ diphosphatase activity
Sfum_0228	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Sfum_0234	COG4957	zinc ion binding
Sfum_0238	COG0406	alpha-ribazole phosphatase activity
Sfum_0240	COG2226	methyltransferase
Sfum_0242	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Sfum_0243	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Sfum_0246	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Sfum_0248	COG5487	UPF0391 membrane protein
Sfum_0252	COG1136	(ABC) transporter
Sfum_0253	COG0577	efflux transmembrane transporter activity
Sfum_0253	COG1136	(ABC) transporter
Sfum_0255	COG0577	efflux transmembrane transporter activity
Sfum_0258	COG1515	deoxyribonuclease V activity
Sfum_0260	COG0443	Heat shock 70 kDa protein
Sfum_0263	COG0542	response to heat
Sfum_0264	COG0640	Transcriptional regulator
Sfum_0266	COG2226	methyltransferase
Sfum_0268	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Sfum_0277	COG0528	UMP kinase activity
Sfum_0280	COG3738	Protein conserved in bacteria
Sfum_0281	COG5002	protein histidine kinase activity
Sfum_0283	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Sfum_0284	COG0581	inorganic phosphate transmembrane transporter activity
Sfum_0285	COG0573	inorganic phosphate transmembrane transporter activity
Sfum_0286	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Sfum_0287	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Sfum_0289	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Sfum_0290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Sfum_0292	COG0628	permease
Sfum_0294	COG2205	protein histidine kinase activity
Sfum_0297	COG0318	PFAM AMP-dependent synthetase and ligase
Sfum_0298	COG0667	Aldo Keto reductase
Sfum_0301	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Sfum_0301	COG0674	pyruvate-flavodoxin oxidoreductase activity
Sfum_0303	COG3829	transcription factor binding
Sfum_0303	COG3290	protein histidine kinase activity
Sfum_0306	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Sfum_0308	COG0617	tRNA 3'-terminal CCA addition
Sfum_0309	COG0517	IMP dehydrogenase activity
Sfum_0310	COG0410	ABC transporter
Sfum_0311	COG0411	ABC transporter
Sfum_0314	COG0683	leucine binding
Sfum_0318	COG1100	Small GTP-binding protein
Sfum_0323	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Sfum_0338	COG1294	oxidase, subunit
Sfum_0339	COG1271	oxidase subunit
Sfum_0340	COG0655	NAD(P)H dehydrogenase (quinone) activity
Sfum_0343	COG0443	Heat shock 70 kDa protein
Sfum_0346	COG1663	tetraacyldisaccharide 4'-kinase activity
Sfum_0350	COG4957	zinc ion binding
Sfum_0353	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Sfum_0356	COG0129	dihydroxy-acid dehydratase activity
Sfum_0360	COG0789	Transcriptional regulator
Sfum_0361	COG0731	radical SAM domain protein
Sfum_0361	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Sfum_0362	COG0612	Peptidase, M16
Sfum_0365	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Sfum_0366	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Sfum_0367	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Sfum_0368	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Sfum_0369	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Sfum_0370	COG0859	PFAM glycosyl transferase family 9
Sfum_0371	COG0859	PFAM glycosyl transferase family 9
Sfum_0372	COG0859	PFAM glycosyl transferase family 9
Sfum_0373	COG0438	transferase activity, transferring glycosyl groups
Sfum_0376	COG1560	Kdo2-lipid A biosynthetic process
Sfum_0379	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Sfum_0380	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Sfum_0381	COG0671	phosphoesterase, PA-phosphatase related
Sfum_0382	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Sfum_0383	COG0410	ABC transporter
Sfum_0384	COG0411	ABC transporter
Sfum_0385	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sfum_0388	COG0427	acetyl-CoA hydrolase
Sfum_0389	COG0427	acetyl-CoA hydrolase
Sfum_0392	COG0277	FAD linked oxidase domain protein
Sfum_0393	COG0247	lactate metabolic process
Sfum_0398	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Sfum_0400	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Sfum_0401	COG1127	ABC transporter
Sfum_0402	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Sfum_0406	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Sfum_0411	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Sfum_0414	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Sfum_0417	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Sfum_0419	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Sfum_0423	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Sfum_0424	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Sfum_0425	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Sfum_0426	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Sfum_0427	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Sfum_0428	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Sfum_0429	COG0072	phenylalanine-tRNA ligase activity
Sfum_0431	COG1971	Probably functions as a manganese efflux pump
Sfum_0432	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Sfum_0433	COG0047	phosphoribosylformylglycinamidine synthase activity
Sfum_0434	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Sfum_0438	COG0535	radical SAM domain protein
Sfum_0439	COG1234	tRNA 3'-trailer cleavage
Sfum_0446	COG1309	transcriptional regulator
Sfum_0448	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Sfum_0449	COG0022	dehydrogenase e1 component
Sfum_0450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Sfum_0451	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Sfum_0452	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Sfum_0454	COG0586	Pfam SNARE associated Golgi protein
Sfum_0455	COG0346	lactoylglutathione lyase activity
Sfum_0460	COG0039	L-malate dehydrogenase activity
Sfum_0461	COG5016	pyruvate
Sfum_0461	COG0511	ligase activity, forming carbon-carbon bonds
Sfum_0464	COG0330	HflC and HflK could
Sfum_0466	COG1573	uracil-dna glycosylase
Sfum_0467	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Sfum_0469	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sfum_0472	COG1127	ABC transporter
Sfum_0473	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Sfum_0478	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Sfum_0483	COG0107	imidazoleglycerol-phosphate synthase activity
Sfum_0484	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Sfum_0485	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Sfum_0486	COG1388	LysM domain
Sfum_0486	COG3942	CHAP domain
Sfum_0487	COG1950	PFAM Membrane protein of
Sfum_0489	COG1940	carbohydrate kinase activity
Sfum_0494	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sfum_0495	COG1120	ATPase activity
Sfum_0497	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Sfum_0498	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Sfum_0498	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Sfum_0500	COG0105	UTP biosynthetic process
Sfum_0501	COG1755	Isoprenylcysteine carboxyl methyltransferase
Sfum_0502	COG0210	DNA helicase
Sfum_0504	COG4957	zinc ion binding
Sfum_0509	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Sfum_0510	COG4106	trans-aconitate 2-methyltransferase activity
Sfum_0517	COG2264	protein methyltransferase activity
Sfum_0519	COG0371	Dehydrogenase
Sfum_0520	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Sfum_0522	COG1028	Short-chain dehydrogenase reductase Sdr
Sfum_0531	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Sfum_0534	COG0277	FAD linked oxidase domain protein
Sfum_0535	COG3876	Protein conserved in bacteria
Sfum_0543	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Sfum_0545	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Sfum_0546	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Sfum_0547	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Sfum_0548	COG1619	proteins homologs of microcin C7 resistance protein MccF
Sfum_0549	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Sfum_0550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Sfum_0551	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Sfum_0552	COG2814	Major facilitator Superfamily
Sfum_0556	COG0515	serine threonine protein kinase
Sfum_0556	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Sfum_0561	COG0018	arginyl-trna synthetase
Sfum_0562	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Sfum_0564	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Sfum_0565	COG0343	queuine tRNA-ribosyltransferase activity
Sfum_0567	COG1278	Cold shock
Sfum_0572	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Sfum_0572	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Sfum_0574	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Sfum_0581	COG4191	Histidine kinase
Sfum_0582	COG4566	intracellular signal transduction
Sfum_0583	COG4566	intracellular signal transduction
Sfum_0588	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Sfum_0589	COG1027	Aspartate ammonia-lyase
Sfum_0593	COG0628	permease
Sfum_0595	COG0822	iron-sulfur transferase activity
Sfum_0598	COG0681	Belongs to the peptidase S26 family
Sfum_0599	COG1595	DNA-templated transcription, initiation
Sfum_0601	COG0726	polysaccharide deacetylase
Sfum_0608	COG5557	Pfam Polysulphide reductase, NrfD
Sfum_0609	COG0437	4 iron, 4 sulfur cluster binding
Sfum_0610	COG0243	molybdopterin cofactor binding
Sfum_0615	COG1910	domain protein
Sfum_0617	COG4191	Histidine kinase
Sfum_0618	COG2204	response regulator
Sfum_0619	COG3852	Histidine kinase
Sfum_0621	COG2204	response regulator
Sfum_0622	COG3852	Histidine kinase
Sfum_0624	COG0589	response to stress
Sfum_0626	COG0730	response to heat
Sfum_0630	COG0574	Belongs to the PEP-utilizing enzyme family
Sfum_0630	COG3848	Pyruvate phosphate dikinase
Sfum_0632	COG0745	RESPONSE REGULATOR receiver
Sfum_0633	COG2204	response regulator
Sfum_0636	COG0745	RESPONSE REGULATOR receiver
Sfum_0638	COG0730	response to heat
Sfum_0640	COG1914	H( )-stimulated, divalent metal cation uptake system
Sfum_0642	COG4191	Histidine kinase
Sfum_0643	COG2204	response regulator
Sfum_0648	COG2204	response regulator
Sfum_0649	COG0574	Belongs to the PEP-utilizing enzyme family
Sfum_0649	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Sfum_0652	COG0745	RESPONSE REGULATOR receiver
Sfum_0654	COG2204	response regulator
Sfum_0657	COG0745	RESPONSE REGULATOR receiver
Sfum_0659	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Sfum_0660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Sfum_0665	COG0693	protein deglycase activity
Sfum_0666	COG0842	Transport permease protein
Sfum_0668	COG4251	negative regulation of phosphorylation
Sfum_0676	COG0439	Biotin carboxylase
Sfum_0679	COG0617	tRNA 3'-terminal CCA addition
Sfum_0681	COG1994	Peptidase M50
Sfum_0682	COG0180	Tryptophanyl-tRNA synthetase
Sfum_0683	COG1187	pseudouridine synthase activity
Sfum_0685	COG0515	serine threonine protein kinase
Sfum_0685	COG2815	serine threonine protein kinase
Sfum_0689	COG1773	rubredoxin
Sfum_0691	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Sfum_0692	COG0805	protein transport
Sfum_0695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Sfum_0696	COG1333	cytochrome c biogenesis protein
Sfum_0698	COG3118	belongs to the thioredoxin family
Sfum_0698	COG0492	ferredoxin-NADP+ reductase activity
Sfum_0700	COG0704	Plays a role in the regulation of phosphate uptake
Sfum_0701	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Sfum_0702	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Sfum_0703	COG0581	inorganic phosphate transmembrane transporter activity
Sfum_0704	COG0573	inorganic phosphate transmembrane transporter activity
Sfum_0705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Sfum_0706	COG5002	protein histidine kinase activity
Sfum_0708	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Sfum_0708	COG1042	CoA-binding domain protein
Sfum_0708	COG0045	succinate-CoA ligase (ADP-forming) activity
Sfum_0712	COG1181	Belongs to the D-alanine--D-alanine ligase family
Sfum_0713	COG1181	Belongs to the D-alanine--D-alanine ligase family
Sfum_0715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Sfum_0716	COG0037	tRNA processing
Sfum_0718	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Sfum_0719	COG3706	GGDEF domain
Sfum_0721	COG0010	Belongs to the arginase family
Sfum_0722	COG4535	Mg2 and Co2 transporter CorC
Sfum_0723	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Sfum_0724	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Sfum_0725	COG1968	undecaprenyl-diphosphatase activity
Sfum_0727	COG0004	ammonium transporteR
Sfum_0728	COG0557	exoribonuclease II activity
Sfum_0730	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Sfum_0731	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Sfum_0736	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Sfum_0738	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Sfum_0739	COG0308	aminopeptidase N
Sfum_0741	COG0737	Belongs to the 5'-nucleotidase family
Sfum_0745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Sfum_0746	COG0427	acetyl-CoA hydrolase
Sfum_0748	COG0741	lytic transglycosylase activity
Sfum_0750	COG1705	Flagellar rod assembly protein muramidase FlgJ
Sfum_0750	COG1388	LysM domain
Sfum_0751	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Sfum_0755	COG0823	Involved in the tonB-independent uptake of proteins
Sfum_0756	COG2885	chlorophyll binding
Sfum_0758	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Sfum_0761	COG0730	response to heat
Sfum_0766	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Sfum_0767	COG1408	metallophosphoesterase
Sfum_0769	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Sfum_0771	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Sfum_0773	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sfum_0774	COG0529	Catalyzes the synthesis of activated sulfate
Sfum_0781	COG1696	Membrane protein involved in D-alanine export
Sfum_0793	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Sfum_0794	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Sfum_0801	COG0556	nucleotide-excision repair
Sfum_0803	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Sfum_0805	COG0861	Integral membrane protein TerC family
Sfum_0807	COG3291	Pkd domain containing protein
Sfum_0809	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Sfum_0810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Sfum_0811	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Sfum_0813	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Sfum_0814	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sfum_0815	COG0765	amino acid transport
Sfum_0819	COG2048	Heterodisulfide reductase, subunit B
Sfum_0821	COG2204	response regulator
Sfum_0827	COG2204	response regulator
Sfum_0833	COG1012	belongs to the aldehyde dehydrogenase family
Sfum_0835	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sfum_0837	COG0411	ABC transporter
Sfum_0841	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Sfum_0847	COG4624	Iron only hydrogenase large subunit, C-terminal domain
Sfum_0848	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Sfum_0848	COG4624	Iron only hydrogenase large subunit, C-terminal domain
Sfum_0852	COG0328	RNA-DNA hybrid ribonuclease activity
Sfum_0853	COG2204	response regulator
Sfum_0854	COG5002	protein histidine kinase activity
Sfum_0855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Sfum_0864	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sfum_0868	COG0584	glycerophosphoryl diester phosphodiesterase
Sfum_0870	COG0318	PFAM AMP-dependent synthetase and ligase
Sfum_0872	COG3854	ATPases associated with a variety of cellular activities
Sfum_0876	COG0571	ribonuclease III activity
Sfum_0877	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Sfum_0884	COG3409	Peptidoglycan-binding domain 1 protein
Sfum_0884	COG3267	Type II secretory pathway component ExeA
Sfum_0892	COG1733	regulation of RNA biosynthetic process
Sfum_0896	COG0583	DNA-binding transcription factor activity
Sfum_0901	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Sfum_0909	COG1032	radical SAM domain protein
Sfum_0911	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Sfum_0912	COG0670	Belongs to the BI1 family
Sfum_0915	COG4195	phage-related replication protein
Sfum_0918	COG1073	alpha beta
Sfum_0926	COG0697	spore germination
Sfum_0927	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Sfum_0929	COG0587	DNA-directed DNA polymerase activity
Sfum_0933	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Sfum_0934	COG0698	ribose 5-phosphate isomerase
Sfum_0935	COG0517	IMP dehydrogenase activity
Sfum_0938	COG0179	Fumarylacetoacetate (FAA) hydrolase
Sfum_0942	COG4191	Histidine kinase
Sfum_0943	COG4566	intracellular signal transduction
Sfum_0944	COG4566	intracellular signal transduction
Sfum_0948	COG2204	response regulator
Sfum_0957	COG2226	methyltransferase
Sfum_0958	COG1181	Belongs to the D-alanine--D-alanine ligase family
Sfum_0959	COG2244	polysaccharide biosynthetic process
Sfum_0962	COG1216	Glycosyl transferase, family 2
Sfum_0967	COG1215	transferase activity, transferring glycosyl groups
Sfum_0969	COG0438	transferase activity, transferring glycosyl groups
Sfum_0972	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Sfum_0975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Sfum_0977	COG3267	Type II secretory pathway component ExeA
Sfum_0977	COG3409	Peptidoglycan-binding domain 1 protein
Sfum_0979	COG1596	polysaccharide export
Sfum_0984	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Sfum_0986	COG2210	Belongs to the sulfur carrier protein TusA family
Sfum_0993	COG2255	four-way junction helicase activity
Sfum_0994	COG0632	four-way junction helicase activity
Sfum_0995	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Sfum_0996	COG0217	transcriptional regulatory protein
Sfum_0997	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Sfum_0998	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Sfum_1003	COG0243	molybdopterin cofactor binding
Sfum_1004	COG0577	efflux transmembrane transporter activity
Sfum_1004	COG1136	(ABC) transporter
Sfum_1005	COG0577	efflux transmembrane transporter activity
Sfum_1005	COG1136	(ABC) transporter
Sfum_1009	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Sfum_1011	COG0535	radical SAM domain protein
Sfum_1011	COG1433	Dinitrogenase iron-molybdenum cofactor
Sfum_1019	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Sfum_1024	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Sfum_1025	COG1945	arginine decarboxylase activity
Sfum_1031	COG3267	Type II secretory pathway component ExeA
Sfum_1031	COG3409	Peptidoglycan-binding domain 1 protein
Sfum_1033	COG0728	peptidoglycan biosynthetic process
Sfum_1034	COG1420	regulation of RNA biosynthetic process
Sfum_1035	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Sfum_1036	COG0443	Heat shock 70 kDa protein
Sfum_1039	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Sfum_1040	COG1573	uracil-dna glycosylase
Sfum_1044	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Sfum_1046	COG2046	Belongs to the sulfate adenylyltransferase family
Sfum_1049	COG1233	COG1233 Phytoene dehydrogenase and related
Sfum_1051	COG0247	lactate metabolic process
Sfum_1051	COG2181	nitrate reductase activity
Sfum_1058	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Sfum_1060	COG1606	tRNA processing
Sfum_1061	COG0482	sulfurtransferase activity
Sfum_1062	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Sfum_1064	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Sfum_1073	COG4868	Belongs to the UPF0371 family
Sfum_1074	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Sfum_1077	COG1538	Outer membrane efflux protein
Sfum_1079	COG0437	4 iron, 4 sulfur cluster binding
Sfum_1080	COG2414	aldehyde ferredoxin oxidoreductase
Sfum_1082	COG0577	efflux transmembrane transporter activity
Sfum_1082	COG1136	(ABC) transporter
Sfum_1083	COG1136	(ABC) transporter
Sfum_1083	COG0577	efflux transmembrane transporter activity
Sfum_1084	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Sfum_1093	COG4676	Protein conserved in bacteria
Sfum_1095	COG2373	Large extracellular alpha-helical protein
Sfum_1097	COG1671	Belongs to the UPF0178 family
Sfum_1101	COG4822	anaerobic cobalamin biosynthetic process
Sfum_1103	COG1122	ATPase activity
Sfum_1105	COG0726	polysaccharide deacetylase
Sfum_1106	COG0438	transferase activity, transferring glycosyl groups
Sfum_1111	COG0582	viral genome integration into host DNA
Sfum_1120	COG0745	RESPONSE REGULATOR receiver
Sfum_1120	COG2205	protein histidine kinase activity
Sfum_1120	COG4191	Histidine kinase
Sfum_1121	COG0318	PFAM AMP-dependent synthetase and ligase
Sfum_1132	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Sfum_1134	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Sfum_1140	COG0346	lactoylglutathione lyase activity
Sfum_1144	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Sfum_1149	COG0437	4 iron, 4 sulfur cluster binding
Sfum_1151	COG2885	chlorophyll binding
Sfum_1152	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Sfum_1152	COG0357	Ribosomal RNA small subunit methyltransferase G
Sfum_1153	COG0564	pseudouridine synthase activity
Sfum_1154	COG1396	sequence-specific DNA binding
Sfum_1155	COG1285	pathogenesis
Sfum_1164	COG3290	protein histidine kinase activity
Sfum_1164	COG3829	transcription factor binding
Sfum_1166	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Sfum_1166	COG0674	pyruvate-flavodoxin oxidoreductase activity
Sfum_1167	COG1013	pyruvate-flavodoxin oxidoreductase activity
Sfum_1169	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Sfum_1171	COG0436	Aminotransferase
Sfum_1177	COG0492	ferredoxin-NADP+ reductase activity
Sfum_1179	COG0446	pyridine nucleotide-disulphide oxidoreductase
Sfum_1185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Sfum_1187	COG3422	double-strand break repair
Sfum_1198	COG0058	SHG alpha-glucan phosphorylase activity
Sfum_1201	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Sfum_1202	COG0653	protein targeting
Sfum_1204	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Sfum_1205	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Sfum_1207	COG2233	PERMEase
Sfum_1208	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Sfum_1210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Sfum_1213	COG0358	DNA primase activity
Sfum_1214	COG1610	YqeY-like protein
Sfum_1215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Sfum_1217	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Sfum_1219	COG0436	Aminotransferase
Sfum_1222	COG1473	amidohydrolase
Sfum_1223	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Sfum_1226	COG0779	Required for maturation of 30S ribosomal subunits
Sfum_1227	COG0195	Participates in both transcription termination and antitermination
Sfum_1228	COG3266	domain, Protein
Sfum_1228	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Sfum_1230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Sfum_1231	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Sfum_1232	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Sfum_1233	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Sfum_1234	COG1185	polyribonucleotide nucleotidyltransferase activity
Sfum_1235	COG0612	Peptidase, M16
Sfum_1236	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Sfum_1238	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Sfum_1239	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Sfum_1246	COG1218	3'(2'),5'-bisphosphate nucleotidase
Sfum_1247	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Sfum_1254	COG0702	epimerase
Sfum_1260	COG1960	acyl-CoA dehydrogenase activity
Sfum_1263	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Sfum_1265	COG0037	tRNA processing
Sfum_1267	COG0442	prolyl-tRNA aminoacylation
Sfum_1268	COG0071	Belongs to the small heat shock protein (HSP20) family
Sfum_1269	COG0501	Belongs to the peptidase M48B family
Sfum_1271	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Sfum_1278	COG0427	acetyl-CoA hydrolase
Sfum_1281	COG2894	cell division
Sfum_1282	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Sfum_1288	COG1322	Protein conserved in bacteria
Sfum_1289	COG1832	CoA-binding protein
Sfum_1298	COG1355	regulation of microtubule-based process
Sfum_1299	COG2078	PFAM AMMECR1 domain protein
Sfum_1303	COG0489	protein tyrosine kinase activity
Sfum_1305	COG1686	Belongs to the peptidase S11 family
Sfum_1307	COG2234	aminopeptidase activity
Sfum_1309	COG1012	belongs to the aldehyde dehydrogenase family
Sfum_1312	COG2226	methyltransferase
Sfum_1314	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Sfum_1316	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Sfum_1316	COG3608	succinylglutamate desuccinylase aspartoacylase
Sfum_1317	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Sfum_1318	COG0243	molybdopterin cofactor binding
Sfum_1328	COG0667	Aldo Keto reductase
Sfum_1329	COG3901	Regulator of nitric oxide reductase transcription
Sfum_1329	COG0348	domain, Protein
Sfum_1332	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Sfum_1333	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Sfum_1338	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Sfum_1339	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Sfum_1340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Sfum_1345	COG1332	CRISPR-associated RAMP protein, Csm5 family
Sfum_1356	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Sfum_1361	COG0481	GTPase activity
Sfum_1366	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Sfum_1369	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Sfum_1370	COG0416	fatty acid biosynthetic process
Sfum_1372	COG2086	electron transfer activity
Sfum_1373	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Sfum_1375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Sfum_1376	COG0698	ribose 5-phosphate isomerase
Sfum_1377	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Sfum_1378	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Sfum_1378	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Sfum_1380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Sfum_1380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Sfum_1381	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Sfum_1382	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Sfum_1383	COG0455	bacterial-type flagellum organization
Sfum_1384	COG1191	sigma factor activity
Sfum_1388	COG0501	Belongs to the peptidase M48B family
Sfum_1390	COG1132	(ABC) transporter
Sfum_1391	COG1132	(ABC) transporter
Sfum_1393	COG0483	inositol monophosphate 1-phosphatase activity
Sfum_1395	COG1024	Enoyl-CoA hydratase
Sfum_1398	COG0446	pyridine nucleotide-disulphide oxidoreductase
Sfum_1400	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Sfum_1401	COG1309	transcriptional regulator
Sfum_1402	COG1960	acyl-CoA dehydrogenase activity
Sfum_1403	COG0183	Belongs to the thiolase family
Sfum_1404	COG1250	3-hydroxyacyl-CoA dehydrogenase
Sfum_1404	COG1024	Enoyl-CoA hydratase
Sfum_1411	COG0747	negative chemotaxis
Sfum_1413	COG0601	transmembrane transport
Sfum_1416	COG1722	exodeoxyribonuclease VII activity
Sfum_1418	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Sfum_1419	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Sfum_1420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Sfum_1421	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Sfum_1422	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Sfum_1424	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Sfum_1425	COG0776	regulation of translation
Sfum_1427	COG1254	Belongs to the acylphosphatase family
Sfum_1428	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Sfum_1430	COG0776	regulation of translation
Sfum_1434	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Sfum_1435	COG1032	radical SAM domain protein
Sfum_1436	COG0456	acetyltransferase
Sfum_1438	COG0537	adenosine 5'-monophosphoramidase activity
Sfum_1445	COG3573	Dehydrogenase
Sfum_1446	COG0784	Response regulator, receiver
Sfum_1447	COG4251	negative regulation of phosphorylation
Sfum_1452	COG0513	Belongs to the DEAD box helicase family
Sfum_1462	COG3064	Membrane
Sfum_1469	COG0191	fructose-bisphosphate aldolase activity
Sfum_1470	COG0058	SHG alpha-glucan phosphorylase activity
Sfum_1472	COG0280	phosphate acetyltransferase
Sfum_1472	COG0857	belongs to the CobB CobQ family
Sfum_1473	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Sfum_1476	COG2985	domain, Protein
Sfum_1476	COG0569	domain protein
Sfum_1477	COG0588	phosphoglycerate mutase activity
Sfum_1479	COG2414	aldehyde ferredoxin oxidoreductase
Sfum_1487	COG3852	Histidine kinase
Sfum_1488	COG2204	response regulator
Sfum_1493	COG4964	Belongs to the GSP D family
Sfum_1503	COG3267	Type II secretory pathway component ExeA
Sfum_1503	COG3409	Peptidoglycan-binding domain 1 protein
Sfum_1504	COG3842	ATPase activity
Sfum_1506	COG1366	Belongs to the anti-sigma-factor antagonist family
Sfum_1513	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Sfum_1516	COG2203	Gaf domain
Sfum_1516	COG3706	GGDEF domain
Sfum_1516	COG4251	negative regulation of phosphorylation
Sfum_1516	COG5001	Diguanylate cyclase
Sfum_1521	COG0730	response to heat
Sfum_1522	COG2186	Transcriptional regulator
Sfum_1527	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Sfum_1529	COG3263	regulation of cellular component size
Sfum_1531	COG0679	Auxin Efflux Carrier
Sfum_1533	COG0372	Belongs to the citrate synthase family
Sfum_1541	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Sfum_1542	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Sfum_1543	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Sfum_1545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Sfum_1546	COG0081	regulation of translation
Sfum_1547	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Sfum_1548	COG0222	ribosome binding
Sfum_1549	COG0085	RNA polymerase activity
Sfum_1550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Sfum_1551	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Sfum_1552	COG0049	tRNA binding
Sfum_1553	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Sfum_1554	COG0051	transcription antitermination factor activity, RNA binding
Sfum_1555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Sfum_1556	COG0088	Forms part of the polypeptide exit tunnel
Sfum_1557	COG0089	rRNA binding
Sfum_1558	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Sfum_1559	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Sfum_1560	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Sfum_1561	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Sfum_1562	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Sfum_1563	COG0255	Belongs to the universal ribosomal protein uL29 family
Sfum_1564	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Sfum_1565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Sfum_1566	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Sfum_1567	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Sfum_1568	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Sfum_1569	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Sfum_1570	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Sfum_1571	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Sfum_1572	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Sfum_1573	COG1841	ribosomal large subunit assembly
Sfum_1574	COG0200	Binds to the 23S rRNA
Sfum_1576	COG0563	adenylate kinase activity
Sfum_1578	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Sfum_1579	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Sfum_1580	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Sfum_1581	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Sfum_1582	COG0202	RNA polymerase activity
Sfum_1583	COG0203	ribosomal protein L17
Sfum_1585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Sfum_1586	COG0142	geranyltranstransferase activity
Sfum_1588	COG1648	precorrin-2 dehydrogenase activity
Sfum_1588	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Sfum_1589	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Sfum_1590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Sfum_1592	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Sfum_1595	COG0629	single-stranded DNA binding
Sfum_1597	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Sfum_1598	COG1674	ftsk spoiiie
Sfum_1600	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Sfum_1601	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Sfum_1602	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Sfum_1603	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Sfum_1604	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Sfum_1605	COG0356	it plays a direct role in the translocation of protons across the membrane
Sfum_1608	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Sfum_1609	COG1530	ribonuclease E activity
Sfum_1610	COG1032	radical SAM domain protein
Sfum_1613	COG0037	tRNA processing
Sfum_1627	COG0668	transmembrane transport
Sfum_1632	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Sfum_1632	COG3264	Mechanosensitive ion channel
Sfum_1634	COG0215	cysteine-tRNA ligase activity
Sfum_1636	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Sfum_1637	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Sfum_1639	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Sfum_1642	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sfum_1645	COG2201	protein-glutamate methylesterase activity
Sfum_1647	COG0835	chemotaxis
Sfum_1648	COG0840	transmembrane signaling receptor activity
Sfum_1649	COG2201	protein-glutamate methylesterase activity
Sfum_1650	COG0643	Histidine kinase
Sfum_1650	COG2198	Histidine kinase
Sfum_1650	COG0643	Histidine kinase
Sfum_1650	COG2198	Histidine kinase
Sfum_1651	COG2201	protein-glutamate methylesterase activity
Sfum_1652	COG2201	protein-glutamate methylesterase activity
Sfum_1654	COG1100	Small GTP-binding protein
Sfum_1656	COG1234	tRNA 3'-trailer cleavage
Sfum_1657	COG0598	Magnesium transport protein CorA
Sfum_1663	COG0745	RESPONSE REGULATOR receiver
Sfum_1664	COG2197	response regulator
Sfum_1666	COG0101	tRNA pseudouridine synthase activity
Sfum_1667	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Sfum_1668	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Sfum_1669	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Sfum_1675	COG0321	lipoyl(octanoyl) transferase activity
Sfum_1676	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Sfum_1678	COG0411	ABC transporter
Sfum_1683	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Sfum_1685	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Sfum_1685	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Sfum_1687	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Sfum_1691	COG1752	Esterase of the alpha-beta hydrolase superfamily
Sfum_1692	COG0351	phosphomethylpyrimidine kinase
Sfum_1693	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Sfum_1698	COG1111	helicase
Sfum_1698	COG1205	dead DEAH box helicase
Sfum_1700	COG0303	'Molybdopterin
Sfum_1702	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Sfum_1703	COG0045	succinate-CoA ligase (ADP-forming) activity
Sfum_1705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Sfum_1706	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Sfum_1707	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Sfum_1708	COG3118	belongs to the thioredoxin family
Sfum_1711	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Sfum_1712	COG0254	rRNA binding
Sfum_1713	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Sfum_1714	COG2890	protein-(glutamine-N5) methyltransferase activity
Sfum_1715	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Sfum_1716	COG2333	competence protein COMEC
Sfum_1716	COG0658	competence protein
Sfum_1718	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Sfum_1721	COG0753	catalase activity
Sfum_1723	COG0493	'glutamate synthase
Sfum_1724	COG0069	glutamate synthase activity
Sfum_1724	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Sfum_1728	COG0284	orotidine-5'-phosphate decarboxylase activity
Sfum_1731	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Sfum_1732	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sfum_1736	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Sfum_1737	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Sfum_1738	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Sfum_1739	COG1492	cobalamin metabolic process
Sfum_1740	COG1797	cobyrinic acid a,c-diamide synthase activity
Sfum_1741	COG1074	ATP-dependent DNA helicase activity
Sfum_1742	COG0071	Belongs to the small heat shock protein (HSP20) family
Sfum_1749	COG1268	BioY protein
Sfum_1750	COG1122	ATPase activity
Sfum_1751	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Sfum_1756	COG0484	heat shock protein binding
Sfum_1758	COG1758	RNA polymerase activity
Sfum_1762	COG0667	Aldo Keto reductase
Sfum_1764	COG0116	Belongs to the methyltransferase superfamily
Sfum_1767	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Sfum_1770	COG0159	tryptophan synthase activity
Sfum_1771	COG0133	tryptophan synthase activity
Sfum_1773	COG0134	indole-3-glycerol-phosphate synthase activity
Sfum_1774	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Sfum_1775	COG0512	Glutamine amidotransferase of anthranilate synthase
Sfum_1776	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Sfum_1777	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Sfum_1778	COG0052	Belongs to the universal ribosomal protein uS2 family
Sfum_1779	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Sfum_1780	COG0528	UMP kinase activity
Sfum_1781	COG0233	cytoplasmic translational termination
Sfum_1782	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Sfum_1783	COG0575	Belongs to the CDS family
Sfum_1784	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Sfum_1785	COG0750	zinc metalloprotease
Sfum_1786	COG1214	PFAM Peptidase M22, glycoprotease
Sfum_1795	COG3383	formate dehydrogenase (NAD+) activity
Sfum_1796	COG3383	formate dehydrogenase (NAD+) activity
Sfum_1800	COG0445	tRNA wobble uridine modification
Sfum_1801	COG0247	lactate metabolic process
Sfum_1801	COG2181	nitrate reductase activity
Sfum_1808	COG3158	transport of potassium into the cell
Sfum_1809	COG1160	GTP binding
Sfum_1812	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Sfum_1815	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Sfum_1817	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Sfum_1818	COG3360	Dodecin
Sfum_1821	COG2022	thiamine diphosphate biosynthetic process
Sfum_1824	COG0352	thiamine-phosphate diphosphorylase activity
Sfum_1825	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Sfum_1826	COG0842	Transport permease protein
Sfum_1831	COG1530	ribonuclease E activity
Sfum_1835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Sfum_1838	COG2183	response to ionizing radiation
Sfum_1841	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Sfum_1842	COG1027	Aspartate ammonia-lyase
Sfum_1843	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Sfum_1844	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Sfum_1851	COG3960	tartronate-semialdehyde synthase activity
Sfum_1860	COG1132	(ABC) transporter
Sfum_1861	COG0784	Response regulator, receiver
Sfum_1862	COG4251	negative regulation of phosphorylation
Sfum_1863	COG1611	Belongs to the LOG family
Sfum_1865	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Sfum_1876	COG4373	Mu-like prophage FluMu protein gp28
Sfum_1877	COG4383	Mu-like prophage protein gp29
Sfum_1882	COG4397	Mu-like prophage major head subunit gpT
Sfum_1884	COG4387	Mu-like prophage protein GP36
Sfum_1905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Sfum_1907	COG0583	DNA-binding transcription factor activity
Sfum_1909	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Sfum_1913	COG1940	carbohydrate kinase activity
Sfum_1915	COG0517	IMP dehydrogenase activity
Sfum_1917	COG1077	Cell shape determining protein MreB Mrl
Sfum_1919	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Sfum_1920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Sfum_1923	COG4221	oxidoreductase activity
Sfum_1926	COG0564	pseudouridine synthase activity
Sfum_1931	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Sfum_1933	COG5000	phosphorelay sensor kinase activity
Sfum_1934	COG2204	response regulator
Sfum_1935	COG1007	ATP synthesis coupled electron transport
Sfum_1936	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sfum_1937	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Sfum_1938	COG0713	ATP synthesis coupled electron transport
Sfum_1940	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sfum_1941	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Sfum_1942	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sfum_1942	COG0649	NAD binding
Sfum_1942	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sfum_1943	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sfum_1945	COG3209	COG3209 Rhs family protein
Sfum_1946	COG3209	COG3209 Rhs family protein
Sfum_1951	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Sfum_1952	COG0166	Belongs to the GPI family
Sfum_1953	COG1940	carbohydrate kinase activity
Sfum_1956	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Sfum_1958	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sfum_1961	COG1433	Dinitrogenase iron-molybdenum cofactor
Sfum_1961	COG0535	radical SAM domain protein
Sfum_1962	COG0616	signal peptide processing
Sfum_1967	COG0432	Pfam Uncharacterised protein family UPF0047
Sfum_1977	COG0446	pyridine nucleotide-disulphide oxidoreductase
Sfum_1979	COG4464	protein tyrosine phosphatase activity
Sfum_1981	COG1082	Xylose isomerase domain protein TIM barrel
Sfum_1983	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Sfum_1984	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Sfum_1985	COG0602	queuosine metabolic process
Sfum_1988	COG1309	transcriptional regulator
Sfum_1989	COG1657	PFAM Prenyltransferase squalene oxidase
Sfum_1994	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Sfum_1996	COG2078	PFAM AMMECR1 domain protein
Sfum_1997	COG0204	Acyl-transferase
Sfum_1998	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Sfum_1999	COG1053	succinate dehydrogenase
Sfum_2006	COG2205	protein histidine kinase activity
Sfum_2012	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Sfum_2015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Sfum_2032	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Sfum_2034	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Sfum_2040	COG2321	neutral zinc metallopeptidase
Sfum_2044	COG1388	LysM domain
Sfum_2051	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sfum_2052	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Sfum_2057	COG3177	Filamentation induced by cAMP protein fic
Sfum_2059	COG0149	triose-phosphate isomerase activity
Sfum_2060	COG0126	phosphoglycerate kinase activity
Sfum_2062	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Sfum_2063	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Sfum_2063	COG0574	Belongs to the PEP-utilizing enzyme family
Sfum_2066	COG1660	Displays ATPase and GTPase activities
Sfum_2067	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sfum_2073	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Sfum_2074	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Sfum_2075	COG0504	CTP synthase activity
Sfum_2077	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Sfum_2081	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Sfum_2082	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Sfum_2083	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Sfum_2084	COG0495	leucyl-tRNA aminoacylation
Sfum_2087	COG0268	Binds directly to 16S ribosomal RNA
Sfum_2089	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Sfum_2090	COG0540	Belongs to the ATCase OTCase family
Sfum_2091	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Sfum_2097	COG1917	Cupin 2, conserved barrel domain protein
Sfum_2097	COG4977	sequence-specific DNA binding
Sfum_2102	COG0114	fumarate hydratase activity
Sfum_2103	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Sfum_2105	COG0372	Belongs to the citrate synthase family
Sfum_2106	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Sfum_2107	COG0776	regulation of translation
Sfum_2112	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Sfum_2113	COG0297	glycogen (starch) synthase activity
Sfum_2115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Sfum_2116	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Sfum_2117	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Sfum_2118	COG0539	negative regulation of cytoplasmic translation
Sfum_2118	COG2183	response to ionizing radiation
Sfum_2119	COG0616	signal peptide processing
Sfum_2120	COG0009	L-threonylcarbamoyladenylate synthase
Sfum_2121	COG0248	Ppx GppA phosphatase
Sfum_2121	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Sfum_2122	COG0517	IMP dehydrogenase activity
Sfum_2122	COG0516	GMP reductase activity
Sfum_2123	COG0519	Catalyzes the synthesis of GMP from XMP
Sfum_2129	COG2875	Belongs to the precorrin methyltransferase family
Sfum_2131	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Sfum_2133	COG1120	ATPase activity
Sfum_2134	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sfum_2137	COG1615	UPF0182 protein
Sfum_2143	COG0411	ABC transporter
Sfum_2146	COG0247	lactate metabolic process
Sfum_2150	COG0493	'glutamate synthase
Sfum_2151	COG0543	2 iron, 2 sulfur cluster binding
Sfum_2152	COG1034	ATP synthesis coupled electron transport
Sfum_2156	COG3119	arylsulfatase activity
Sfum_2157	COG0641	radical SAM
Sfum_2161	COG3956	TIGRFAM MazG family protein
Sfum_2163	COG1702	phosphate starvation-inducible protein PhoH
Sfum_2164	COG1480	7TM receptor with intracellular HD hydrolase
Sfum_2165	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Sfum_2166	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Sfum_2167	COG0736	holo-[acyl-carrier-protein] synthase activity
Sfum_2168	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Sfum_2168	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Sfum_2169	COG0802	atpase or kinase
Sfum_2171	COG1032	radical SAM domain protein
Sfum_2173	COG0527	aspartate kinase activity
Sfum_2174	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Sfum_2181	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Sfum_2188	COG0438	transferase activity, transferring glycosyl groups
Sfum_2189	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Sfum_2190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sfum_2195	COG0791	NLP P60 protein
Sfum_2197	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Sfum_2202	COG0516	GMP reductase activity
Sfum_2202	COG0517	IMP dehydrogenase activity
Sfum_2204	COG2770	Histidine kinase
Sfum_2204	COG2208	phosphoserine phosphatase activity
Sfum_2205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Sfum_2210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Sfum_2212	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Sfum_2213	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Sfum_2214	COG3829	transcription factor binding
Sfum_2214	COG3290	protein histidine kinase activity
Sfum_2215	COG1116	anion transmembrane transporter activity
Sfum_2216	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sfum_2221	COG3259	Nickel-dependent hydrogenase
Sfum_2222	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sfum_2226	COG4499	WXG100 protein secretion system (Wss), protein YukC
Sfum_2226	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Sfum_2227	COG2373	Large extracellular alpha-helical protein
Sfum_2233	COG0577	efflux transmembrane transporter activity
Sfum_2233	COG1136	(ABC) transporter
Sfum_2234	COG1136	(ABC) transporter
Sfum_2234	COG0577	efflux transmembrane transporter activity
Sfum_2237	COG0398	Pfam SNARE associated Golgi protein
Sfum_2239	COG0859	PFAM glycosyl transferase family 9
Sfum_2243	COG0463	Glycosyl transferase, family 2
Sfum_2248	COG2132	Multicopper oxidase
Sfum_2251	COG1064	alcohol dehydrogenase
Sfum_2252	COG0602	queuosine metabolic process
Sfum_2261	COG0438	transferase activity, transferring glycosyl groups
Sfum_2271	COG0589	response to stress
Sfum_2272	COG4651	solute:proton antiporter activity
Sfum_2272	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Sfum_2275	COG0306	phosphate transporter
Sfum_2279	COG4412	M6 family metalloprotease domain protein
Sfum_2279	COG1404	Belongs to the peptidase S8 family
Sfum_2284	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sfum_2287	COG2414	aldehyde ferredoxin oxidoreductase
Sfum_2288	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Sfum_2290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Sfum_2291	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Sfum_2292	COG2204	response regulator
Sfum_2294	COG5002	protein histidine kinase activity
Sfum_2301	COG1942	4-Oxalocrotonate Tautomerase
Sfum_2307	COG2200	EAL domain
Sfum_2307	COG2199	diguanylate cyclase activity
Sfum_2307	COG2202	Pas domain
Sfum_2312	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Sfum_2319	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Sfum_2320	COG2249	NAD(P)H dehydrogenase (quinone) activity
Sfum_2323	COG3064	Membrane
Sfum_2324	COG1032	radical SAM domain protein
Sfum_2325	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Sfum_2326	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Sfum_2329	COG2819	hydrolase of the alpha beta superfamily
Sfum_2332	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sfum_2333	COG0534	Mate efflux family protein
Sfum_2336	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Sfum_2336	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Sfum_2338	COG0529	Catalyzes the synthesis of activated sulfate
Sfum_2340	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Sfum_2345	COG0459	protein refolding
Sfum_2348	COG0438	transferase activity, transferring glycosyl groups
Sfum_2352	COG0038	chloride channel
Sfum_2364	COG0484	heat shock protein binding
Sfum_2366	COG0071	Belongs to the small heat shock protein (HSP20) family
Sfum_2367	COG4974	Belongs to the 'phage' integrase family
Sfum_2372	COG0535	radical SAM domain protein
Sfum_2375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Sfum_2376	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Sfum_2377	COG1228	amidohydrolase
Sfum_2378	COG2986	histidine ammonia-lyase
Sfum_2380	COG0860	N-Acetylmuramoyl-L-alanine amidase
Sfum_2380	COG3103	Sh3 type 3 domain protein
Sfum_2380	COG4991	sh3 domain protein
Sfum_2381	COG0501	Belongs to the peptidase M48B family
Sfum_2382	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Sfum_2387	COG0477	Major facilitator Superfamily
Sfum_2391	COG1131	(ABC) transporter
Sfum_2392	COG0842	Transport permease protein
Sfum_2393	COG0842	Transport permease protein
Sfum_2395	COG1914	H( )-stimulated, divalent metal cation uptake system
Sfum_2396	COG2239	Acts as a magnesium transporter
Sfum_2398	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Sfum_2400	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Sfum_2401	COG4191	Histidine kinase
Sfum_2401	COG0784	Response regulator, receiver
Sfum_2404	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Sfum_2408	COG1090	epimerase
Sfum_2409	COG0492	ferredoxin-NADP+ reductase activity
Sfum_2412	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Sfum_2414	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Sfum_2416	COG3008	intermembrane lipid transfer
Sfum_2416	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Sfum_2428	COG4325	translation initiation factor activity
Sfum_2430	COG0535	radical SAM domain protein
Sfum_2433	COG0475	glutathione-regulated potassium exporter activity
Sfum_2433	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Sfum_2438	COG1027	Aspartate ammonia-lyase
Sfum_2439	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Sfum_2442	COG2204	response regulator
Sfum_2445	COG0751	glycine-tRNA ligase activity
Sfum_2446	COG0752	glycyl-tRNA synthetase alpha subunit
Sfum_2449	COG1127	ABC transporter
Sfum_2450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Sfum_2453	COG2208	phosphoserine phosphatase activity
Sfum_2456	COG0641	radical SAM
Sfum_2460	COG0552	protein localization to endoplasmic reticulum
Sfum_2461	COG0191	fructose-bisphosphate aldolase activity
Sfum_2463	COG1063	alcohol dehydrogenase
Sfum_2464	COG1830	Aldolase
Sfum_2466	COG1042	CoA-binding domain protein
Sfum_2466	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Sfum_2466	COG0045	succinate-CoA ligase (ADP-forming) activity
Sfum_2468	COG1592	Rubrerythrin
Sfum_2470	COG1490	D-aminoacyl-tRNA deacylase activity
Sfum_2473	COG1691	(AIR) carboxylase
Sfum_2474	COG1519	Transferase
Sfum_2475	COG0017	Asparaginyl-tRNA synthetase
Sfum_2480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Sfum_2493	COG1918	ferrous iron import across plasma membrane
Sfum_2493	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Sfum_2494	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Sfum_2495	COG4191	Histidine kinase
Sfum_2498	COG0577	efflux transmembrane transporter activity
Sfum_2507	COG1136	(ABC) transporter
Sfum_2509	COG2080	2 iron, 2 sulfur cluster binding
Sfum_2510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Sfum_2512	COG0693	protein deglycase activity
Sfum_2516	COG1129	ABC transporter
Sfum_2521	COG1136	(ABC) transporter
Sfum_2524	COG1408	metallophosphoesterase
Sfum_2526	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Sfum_2527	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Sfum_2528	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Sfum_2530	COG1058	Belongs to the CinA family
Sfum_2530	COG1546	Belongs to the CinA family
Sfum_2531	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Sfum_2534	COG1715	Restriction endonuclease
Sfum_2537	COG2815	serine threonine protein kinase
Sfum_2537	COG0515	serine threonine protein kinase
Sfum_2541	COG1716	ATPase activity
Sfum_2542	COG0430	RNA-3'-phosphate cyclase activity
Sfum_2547	COG1331	Highly conserved protein containing a thioredoxin domain
Sfum_2548	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Sfum_2558	COG4968	Prepilin-type N-terminal cleavage methylation domain
Sfum_2560	COG5002	protein histidine kinase activity
Sfum_2562	COG0574	Belongs to the PEP-utilizing enzyme family
Sfum_2562	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Sfum_2570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Sfum_2571	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sfum_2572	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sfum_2574	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Sfum_2578	COG1418	mRNA catabolic process
Sfum_2580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Sfum_2581	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Sfum_2582	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Sfum_2583	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Sfum_2584	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Sfum_2585	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Sfum_2586	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Sfum_2588	COG0772	Belongs to the SEDS family
Sfum_2592	COG1077	Cell shape determining protein MreB Mrl
Sfum_2594	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Sfum_2595	COG0594	ribonuclease P activity
Sfum_2596	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Sfum_2597	COG0706	membrane insertase activity
Sfum_2598	COG1847	R3H domain protein
Sfum_2599	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Sfum_2601	COG0357	Ribosomal RNA small subunit methyltransferase G
Sfum_2603	COG1535	isochorismatase
Sfum_2603	COG3433	isochorismatase activity
Sfum_2605	COG1192	Involved in chromosome partitioning
Sfum_2606	COG1475	DNA binding
Sfum_2609	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Sfum_2611	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Sfum_2612	COG0315	cyclic pyranopterin monophosphate synthase activity
Sfum_2616	COG1132	(ABC) transporter
Sfum_2617	COG2205	protein histidine kinase activity
Sfum_2618	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Sfum_2620	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Sfum_2621	COG5002	protein histidine kinase activity
Sfum_2624	COG0275	rRNA processing
Sfum_2630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Sfum_2631	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Sfum_2632	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Sfum_2642	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Sfum_2643	COG0513	Belongs to the DEAD box helicase family
Sfum_2644	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Sfum_2645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Sfum_2646	COG0508	dehydrogenase complex catalyzes the overall conversion of
Sfum_2650	COG3706	GGDEF domain
Sfum_2654	COG4452	Inner membrane protein CreD
Sfum_2656	COG0745	RESPONSE REGULATOR receiver
Sfum_2657	COG2205	protein histidine kinase activity
Sfum_2669	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Sfum_2675	COG4191	Histidine kinase
Sfum_2676	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Sfum_2677	COG1199	ATP-dependent helicase activity
Sfum_2682	COG1045	serine acetyltransferase
Sfum_2686	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Sfum_2687	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Sfum_2688	COG0592	DNA-directed DNA polymerase activity
Sfum_2689	COG0187	DNA topoisomerase II activity
Sfum_2691	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Sfum_2693	COG1477	protein flavinylation
Sfum_2694	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
Sfum_2694	COG2878	Part of a membrane complex involved in electron transport
Sfum_2695	COG4657	Part of a membrane complex involved in electron transport
Sfum_2696	COG4660	Part of a membrane complex involved in electron transport
Sfum_2697	COG4659	FMN binding
Sfum_2698	COG4658	electron transport chain
Sfum_2705	COG3383	formate dehydrogenase (NAD+) activity
Sfum_2706	COG3383	formate dehydrogenase (NAD+) activity
Sfum_2707	COG2116	formate transmembrane transporter activity
Sfum_2710	COG1047	Peptidyl-prolyl cis-trans
Sfum_2715	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
Sfum_2716	COG3259	Nickel-dependent hydrogenase
Sfum_2720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Sfum_2721	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Sfum_2722	COG0710	3-dehydroquinate dehydratase activity
Sfum_2723	COG1605	Chorismate mutase
Sfum_2723	COG0077	Prephenate dehydratase
Sfum_2724	COG1465	3-dehydroquinate synthase
Sfum_2731	COG0784	Response regulator, receiver
Sfum_2734	COG1121	(ABC) transporter
Sfum_2735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Sfum_2736	COG1657	PFAM Prenyltransferase squalene oxidase
Sfum_2737	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Sfum_2739	COG1120	ATPase activity
Sfum_2740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sfum_2744	COG4771	TonB-dependent receptor
Sfum_2745	COG4822	anaerobic cobalamin biosynthetic process
Sfum_2748	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sfum_2753	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Sfum_2756	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Sfum_2757	COG0009	L-threonylcarbamoyladenylate synthase
Sfum_2758	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Sfum_2759	COG0151	Belongs to the GarS family
Sfum_2760	COG0138	bifunctional purine biosynthesis protein purh
Sfum_2763	COG3852	Histidine kinase
Sfum_2764	COG2204	response regulator
Sfum_2768	COG0598	Magnesium transport protein CorA
Sfum_2784	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Sfum_2788	COG0590	tRNA wobble adenosine to inosine editing
Sfum_2789	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Sfum_2790	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Sfum_2791	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Sfum_2792	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Sfum_2794	COG0674	pyruvate-flavodoxin oxidoreductase activity
Sfum_2795	COG1013	pyruvate-flavodoxin oxidoreductase activity
Sfum_2802	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Sfum_2805	COG0509	glycine decarboxylation via glycine cleavage system
Sfum_2806	COG2204	response regulator
Sfum_2807	COG3852	Histidine kinase
Sfum_2808	COG1104	cysteine desulfurase activity
Sfum_2810	COG0577	efflux transmembrane transporter activity
Sfum_2810	COG1136	(ABC) transporter
Sfum_2817	COG1136	(ABC) transporter
Sfum_2817	COG0577	efflux transmembrane transporter activity
Sfum_2819	COG1342	Belongs to the UPF0251 family
Sfum_2822	COG0419	ATPase involved in DNA repair
Sfum_2827	COG1857	crispr-associated protein
Sfum_2830	COG1518	maintenance of DNA repeat elements
Sfum_2831	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Sfum_2834	COG2226	methyltransferase
Sfum_2837	COG4251	negative regulation of phosphorylation
Sfum_2845	COG1073	alpha beta
Sfum_2848	COG0537	adenosine 5'-monophosphoramidase activity
Sfum_2851	COG0543	2 iron, 2 sulfur cluster binding
Sfum_2856	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Sfum_2857	COG0464	growth
Sfum_2859	COG0210	DNA helicase
Sfum_2860	COG0071	Belongs to the small heat shock protein (HSP20) family
Sfum_2864	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Sfum_2873	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Sfum_2875	COG1151	hydroxylamine reductase activity
Sfum_2876	COG3420	alginic acid biosynthetic process
Sfum_2880	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Sfum_2881	COG1403	HNH endonuclease
Sfum_2882	COG0564	pseudouridine synthase activity
Sfum_2884	COG0640	Transcriptional regulator
Sfum_2885	COG4232	protein-disulfide reductase activity
Sfum_2886	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Sfum_2887	COG0573	inorganic phosphate transmembrane transporter activity
Sfum_2888	COG0581	inorganic phosphate transmembrane transporter activity
Sfum_2889	COG0704	Plays a role in the regulation of phosphate uptake
Sfum_2890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Sfum_2891	COG5002	protein histidine kinase activity
Sfum_2892	COG0745	RESPONSE REGULATOR receiver
Sfum_2894	COG1803	Methylglyoxal synthase
Sfum_2895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Sfum_2896	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Sfum_2898	COG3842	ATPase activity
Sfum_2899	COG1840	ABC-type Fe3 transport system, periplasmic component
Sfum_2902	COG0688	phosphatidylethanolamine metabolic process
Sfum_2903	COG0438	transferase activity, transferring glycosyl groups
Sfum_2903	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Sfum_2904	COG0704	Plays a role in the regulation of phosphate uptake
Sfum_2906	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Sfum_2908	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Sfum_2912	COG0363	glucosamine-6-phosphate deaminase activity
Sfum_2913	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Sfum_2921	COG0535	radical SAM domain protein
Sfum_2925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Sfum_2935	COG1773	rubredoxin
Sfum_2941	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Sfum_2943	COG0784	Response regulator, receiver
Sfum_2943	COG4191	Histidine kinase
Sfum_2944	COG2084	Dehydrogenase
Sfum_2945	COG3383	formate dehydrogenase (NAD+) activity
Sfum_2946	COG3383	formate dehydrogenase (NAD+) activity
Sfum_2948	COG2848	UPF0210 protein
Sfum_2952	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Sfum_2953	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Sfum_2954	COG0745	RESPONSE REGULATOR receiver
Sfum_2955	COG2204	response regulator
Sfum_2957	COG0058	SHG alpha-glucan phosphorylase activity
Sfum_2960	COG0402	S-adenosylhomocysteine deaminase activity
Sfum_2961	COG0402	S-adenosylhomocysteine deaminase activity
Sfum_2963	COG1643	Atp-dependent helicase
Sfum_2968	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Sfum_2969	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Sfum_2974	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Sfum_2975	COG0745	RESPONSE REGULATOR receiver
Sfum_2980	COG0440	acetolactate synthase activity
Sfum_2981	COG0028	Belongs to the TPP enzyme family
Sfum_2982	COG0028	Belongs to the TPP enzyme family
Sfum_2983	COG0440	acetolactate synthase activity
Sfum_2984	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Sfum_2985	COG0688	phosphatidylethanolamine metabolic process
Sfum_2986	COG1183	phosphatidylcholine synthase activity
Sfum_2987	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Sfum_2988	COG0066	3-isopropylmalate dehydratase activity
Sfum_2989	COG0473	3-isopropylmalate dehydrogenase activity
Sfum_2990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Sfum_2991	COG0742	ribosomal rna small subunit methyltransferase
Sfum_2992	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Sfum_2993	COG2951	lytic endotransglycosylase activity
Sfum_2995	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Sfum_2996	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Sfum_2997	COG0228	four-way junction DNA binding
Sfum_2998	COG1837	Belongs to the UPF0109 family
Sfum_2999	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Sfum_3000	COG0336	Belongs to the RNA methyltransferase TrmD family
Sfum_3001	COG4752	Belongs to the RNA methyltransferase TrmD family
Sfum_3002	COG0335	large ribosomal subunit rRNA binding
Sfum_3003	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Sfum_3004	COG0792	nuclease activity
Sfum_3005	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Sfum_3008	COG1294	oxidase, subunit
Sfum_3009	COG1271	oxidase subunit
Sfum_3010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Sfum_3011	COG2234	aminopeptidase activity
Sfum_3016	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Sfum_3017	COG0745	RESPONSE REGULATOR receiver
Sfum_3022	COG0440	acetolactate synthase activity
Sfum_3023	COG0028	Belongs to the TPP enzyme family
Sfum_3024	COG0028	Belongs to the TPP enzyme family
Sfum_3025	COG0440	acetolactate synthase activity
Sfum_3026	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Sfum_3027	COG0688	phosphatidylethanolamine metabolic process
Sfum_3028	COG1183	phosphatidylcholine synthase activity
Sfum_3029	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Sfum_3030	COG0066	3-isopropylmalate dehydratase activity
Sfum_3031	COG0473	3-isopropylmalate dehydrogenase activity
Sfum_3032	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Sfum_3033	COG0742	ribosomal rna small subunit methyltransferase
Sfum_3034	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Sfum_3035	COG2951	lytic endotransglycosylase activity
Sfum_3037	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Sfum_3038	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Sfum_3039	COG0228	four-way junction DNA binding
Sfum_3040	COG1837	Belongs to the UPF0109 family
Sfum_3041	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Sfum_3042	COG0336	Belongs to the RNA methyltransferase TrmD family
Sfum_3043	COG4752	Belongs to the RNA methyltransferase TrmD family
Sfum_3044	COG0335	large ribosomal subunit rRNA binding
Sfum_3045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Sfum_3046	COG0792	nuclease activity
Sfum_3047	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Sfum_3050	COG1294	oxidase, subunit
Sfum_3051	COG1271	oxidase subunit
Sfum_3052	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Sfum_3053	COG2234	aminopeptidase activity
Sfum_3054	COG1285	pathogenesis
Sfum_3055	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Sfum_3056	COG0535	radical SAM domain protein
Sfum_3057	COG0113	porphobilinogen synthase activity
Sfum_3058	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Sfum_3063	COG0793	Belongs to the peptidase S41A family
Sfum_3066	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Sfum_3070	COG0427	acetyl-CoA hydrolase
Sfum_3071	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Sfum_3074	COG1763	Mo-molybdopterin cofactor biosynthetic process
Sfum_3075	COG0746	molybdenum cofactor guanylyltransferase activity
Sfum_3076	COG0303	'Molybdopterin
Sfum_3077	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Sfum_3077	COG1213	nucleotidyl transferase
Sfum_3083	COG0138	bifunctional purine biosynthesis protein purh
Sfum_3085	COG1830	Aldolase
Sfum_3088	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Sfum_3089	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Sfum_3090	COG1309	transcriptional regulator
Sfum_3096	COG0497	DNA recombination
Sfum_3098	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Sfum_3100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Sfum_3103	COG4177	L-phenylalanine transmembrane transporter activity
Sfum_3105	COG0683	leucine binding
Sfum_3106	COG0686	Belongs to the AlaDH PNT family
Sfum_3109	COG5002	protein histidine kinase activity
Sfum_3114	COG0463	Glycosyl transferase, family 2
Sfum_3136	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Sfum_3138	COG0674	pyruvate-flavodoxin oxidoreductase activity
Sfum_3138	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Sfum_3139	COG1013	pyruvate-flavodoxin oxidoreductase activity
Sfum_3142	COG1902	pentaerythritol trinitrate reductase activity
Sfum_3142	COG0446	pyridine nucleotide-disulphide oxidoreductase
Sfum_3148	COG2186	Transcriptional regulator
Sfum_3152	COG2226	methyltransferase
Sfum_3155	COG2234	aminopeptidase activity
Sfum_3159	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Sfum_3161	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Sfum_3162	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sfum_3163	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sfum_3164	COG0765	amino acid transport
Sfum_3165	COG0765	amino acid transport
Sfum_3178	COG4412	M6 family metalloprotease domain protein
Sfum_3178	COG1404	Belongs to the peptidase S8 family
Sfum_3182	COG0196	riboflavin kinase activity
Sfum_3184	COG0305	Participates in initiation and elongation during chromosome replication
Sfum_3185	COG0359	binds to the 23S rRNA
Sfum_3187	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Sfum_3188	COG0360	Binds together with S18 to 16S ribosomal RNA
Sfum_3191	COG1837	Belongs to the UPF0109 family
Sfum_3195	COG0243	molybdopterin cofactor binding
Sfum_3197	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Sfum_3200	COG3344	reverse transcriptase
Sfum_3202	COG0181	hydroxymethylbilane synthase activity
Sfum_3206	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Sfum_3214	COG1278	Cold shock
Sfum_3215	COG1090	epimerase
Sfum_3217	COG1141	Ferredoxin
Sfum_3219	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Sfum_3222	COG1773	rubredoxin
Sfum_3223	COG2217	Heavy metal translocating P-type atpase
Sfum_3228	COG0612	Peptidase, M16
Sfum_3231	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Sfum_3233	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Sfum_3236	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Sfum_3237	COG0515	serine threonine protein kinase
Sfum_3237	COG2815	serine threonine protein kinase
Sfum_3244	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Sfum_3246	COG3191	aminopeptidase activity
Sfum_3250	COG1132	(ABC) transporter
Sfum_3252	COG1592	Rubrerythrin
Sfum_3253	COG0426	domain, Protein
Sfum_3256	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Sfum_3263	COG2226	methyltransferase
Sfum_3268	COG2204	response regulator
Sfum_3269	COG3852	Histidine kinase
Sfum_3272	COG2226	methyltransferase
Sfum_3273	COG2226	methyltransferase
Sfum_3274	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Sfum_3277	COG0714	Associated with various cellular activities
Sfum_3278	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Sfum_3279	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Sfum_3280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Sfum_3281	COG1119	ATPase activity
Sfum_3283	COG2003	Belongs to the UPF0758 family
Sfum_3284	COG2854	intermembrane phospholipid transfer
Sfum_3285	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Sfum_3286	COG0437	4 iron, 4 sulfur cluster binding
Sfum_3287	COG0243	molybdopterin cofactor binding
Sfum_3291	COG1960	acyl-CoA dehydrogenase activity
Sfum_3294	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Sfum_3298	COG1324	tolerance protein
Sfum_3299	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Sfum_3300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Sfum_3301	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Sfum_3302	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Sfum_3303	COG0124	histidyl-tRNA synthetase
Sfum_3311	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Sfum_3312	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Sfum_3313	COG0583	DNA-binding transcription factor activity
Sfum_3314	COG0488	(ABC) transporter
Sfum_3315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Sfum_3316	COG1566	PFAM secretion protein HlyD family protein
Sfum_3317	COG2814	Major facilitator Superfamily
Sfum_3321	COG0489	protein tyrosine kinase activity
Sfum_3323	COG0484	heat shock protein binding
Sfum_3324	COG0662	Cupin 2, conserved barrel domain protein
Sfum_3324	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Sfum_3327	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Sfum_3337	COG0297	glycogen (starch) synthase activity
Sfum_3337	COG0438	transferase activity, transferring glycosyl groups
Sfum_3344	COG0438	transferase activity, transferring glycosyl groups
Sfum_3348	COG0463	Glycosyl transferase, family 2
Sfum_3351	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Sfum_3353	COG1216	Glycosyl transferase, family 2
Sfum_3358	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sfum_3361	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sfum_3362	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Sfum_3365	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Sfum_3366	COG0154	amidase activity
Sfum_3367	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Sfum_3370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Sfum_3374	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Sfum_3375	COG0205	6-phosphofructokinase activity
Sfum_3376	COG0702	epimerase
Sfum_3382	COG0546	phosphoglycolate phosphatase activity
Sfum_3387	COG0655	NAD(P)H dehydrogenase (quinone) activity
Sfum_3392	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Sfum_3393	COG4336	lyase activity
Sfum_3394	COG1984	allophanate hydrolase subunit 2
Sfum_3395	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Sfum_3396	COG0410	ABC transporter
Sfum_3399	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sfum_3401	COG0709	Synthesizes selenophosphate from selenide and ATP
Sfum_3414	COG1363	Peptidase, m42
Sfum_3415	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Sfum_3417	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Sfum_3419	COG4106	trans-aconitate 2-methyltransferase activity
Sfum_3420	COG0730	response to heat
Sfum_3425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Sfum_3430	COG1335	isochorismatase
Sfum_3431	COG1028	Short-chain dehydrogenase reductase Sdr
Sfum_3433	COG3647	Membrane
Sfum_3434	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Sfum_3435	COG0631	protein serine/threonine phosphatase activity
Sfum_3436	COG1716	ATPase activity
Sfum_3437	COG2234	aminopeptidase activity
Sfum_3438	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Sfum_3446	COG1151	hydroxylamine reductase activity
Sfum_3449	COG2032	superoxide dismutase activity
Sfum_3450	COG2270	Major facilitator Superfamily
Sfum_3451	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Sfum_3452	COG1640	4-alpha-glucanotransferase
Sfum_3454	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Sfum_3459	COG1309	transcriptional regulator
Sfum_3460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Sfum_3462	COG2001	Belongs to the MraZ family
Sfum_3463	COG0275	rRNA processing
Sfum_3466	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Sfum_3467	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Sfum_3468	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Sfum_3469	COG0772	Belongs to the SEDS family
Sfum_3470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Sfum_3471	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Sfum_3474	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Sfum_3476	COG0484	heat shock protein binding
Sfum_3477	COG1921	L-seryl-tRNASec selenium transferase activity
Sfum_3480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Sfum_3482	COG1381	Involved in DNA repair and RecF pathway recombination
Sfum_3483	COG4232	protein-disulfide reductase activity
Sfum_3484	COG3118	belongs to the thioredoxin family
Sfum_3485	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Sfum_3490	COG1116	anion transmembrane transporter activity
Sfum_3491	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sfum_3495	COG1840	ABC-type Fe3 transport system, periplasmic component
Sfum_3496	COG3842	ATPase activity
Sfum_3499	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Sfum_3501	COG2271	Major facilitator Superfamily
Sfum_3503	COG0154	amidase activity
Sfum_3504	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Sfum_3507	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Sfum_3508	COG0352	thiamine-phosphate diphosphorylase activity
Sfum_3509	COG3383	formate dehydrogenase (NAD+) activity
Sfum_3512	COG0861	Integral membrane protein TerC family
Sfum_3516	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Sfum_3517	COG2205	protein histidine kinase activity
Sfum_3519	COG4191	Histidine kinase
Sfum_3520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Sfum_3527	COG2223	nitrite transmembrane transporter activity
Sfum_3532	COG0247	lactate metabolic process
Sfum_3534	COG0446	pyridine nucleotide-disulphide oxidoreductase
Sfum_3536	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Sfum_3537	COG3259	Nickel-dependent hydrogenase
Sfum_3539	COG2855	membrane
Sfum_3542	COG1966	Carbon starvation protein
Sfum_3543	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Sfum_3544	COG4608	Belongs to the ABC transporter superfamily
Sfum_3545	COG0444	Belongs to the ABC transporter superfamily
Sfum_3548	COG0508	dehydrogenase complex catalyzes the overall conversion of
Sfum_3554	COG0363	glucosamine-6-phosphate deaminase activity
Sfum_3555	COG1132	(ABC) transporter
Sfum_3557	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Sfum_3561	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Sfum_3563	COG2226	methyltransferase
Sfum_3566	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Sfum_3569	COG2226	methyltransferase
Sfum_3570	COG0436	Aminotransferase
Sfum_3574	COG3158	transport of potassium into the cell
Sfum_3577	COG2186	Transcriptional regulator
Sfum_3581	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Sfum_3582	COG0183	Belongs to the thiolase family
Sfum_3583	COG1250	3-hydroxyacyl-CoA dehydrogenase
Sfum_3584	COG1024	Enoyl-CoA hydratase
Sfum_3585	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Sfum_3586	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Sfum_3587	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Sfum_3588	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Sfum_3591	COG0166	Belongs to the GPI family
Sfum_3597	COG0701	Predicted permease
Sfum_3601	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Sfum_3602	COG0798	PFAM Bile acid sodium symporter
Sfum_3604	COG3118	belongs to the thioredoxin family
Sfum_3606	COG0731	radical SAM domain protein
Sfum_3606	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Sfum_3607	COG1321	iron dependent repressor
Sfum_3613	COG0489	protein tyrosine kinase activity
Sfum_3614	COG5002	protein histidine kinase activity
Sfum_3615	COG0745	RESPONSE REGULATOR receiver
Sfum_3619	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Sfum_3619	COG0519	Catalyzes the synthesis of GMP from XMP
Sfum_3620	COG0531	amino acid
Sfum_3622	COG0655	NAD(P)H dehydrogenase (quinone) activity
Sfum_3624	COG3852	Histidine kinase
Sfum_3626	COG0084	hydrolase, TatD family'
Sfum_3627	COG0424	maF-like protein
Sfum_3628	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Sfum_3629	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Sfum_3630	COG0194	GDP metabolic process
Sfum_3631	COG2052	Domain of unknown function (DUF370)
Sfum_3632	COG1561	YicC-like family, N-terminal region
Sfum_3634	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Sfum_3634	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Sfum_3635	COG2835	tetraacyldisaccharide 4'-kinase activity
Sfum_3636	COG3599	regulation of cell shape
Sfum_3637	COG0762	integral membrane protein
Sfum_3639	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Sfum_3640	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Sfum_3641	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Sfum_3644	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Sfum_3645	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Sfum_3646	COG0799	negative regulation of ribosome biogenesis
Sfum_3648	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Sfum_3648	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Sfum_3649	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Sfum_3651	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Sfum_3652	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Sfum_3653	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Sfum_3654	COG0193	aminoacyl-tRNA hydrolase activity
Sfum_3655	COG1329	Transcriptional regulator
Sfum_3656	COG4956	integral membrane protein (PIN domain superfamily)
Sfum_3664	COG2165	general secretion pathway protein
Sfum_3665	COG1459	type II secretion system
Sfum_3666	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Sfum_3678	COG1538	Outer membrane efflux protein
Sfum_3679	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Sfum_3680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Sfum_3686	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Sfum_3687	COG2086	electron transfer activity
Sfum_3688	COG1960	acyl-CoA dehydrogenase activity
Sfum_3689	COG1309	transcriptional regulator
Sfum_3692	COG0107	imidazoleglycerol-phosphate synthase activity
Sfum_3697	COG0725	ABC transporter, periplasmic molybdate-binding protein
Sfum_3698	COG4149	molybdate abc transporter
Sfum_3699	COG4772	TonB-dependent receptor
Sfum_3704	COG1120	ATPase activity
Sfum_3708	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Sfum_3709	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Sfum_3710	COG0512	Glutamine amidotransferase of anthranilate synthase
Sfum_3711	COG4106	trans-aconitate 2-methyltransferase activity
Sfum_3711	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Sfum_3712	COG0156	8-amino-7-oxononanoate synthase activity
Sfum_3717	COG1028	Short-chain dehydrogenase reductase Sdr
Sfum_3718	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Sfum_3719	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Sfum_3724	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Sfum_3727	COG0433	COG0433 Predicted ATPase
Sfum_3728	COG2223	nitrite transmembrane transporter activity
Sfum_3731	COG3189	MarR family transcriptional regulator
Sfum_3732	COG1819	glycosyl
Sfum_3737	COG2204	response regulator
Sfum_3742	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Sfum_3744	COG1136	(ABC) transporter
Sfum_3747	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Sfum_3748	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Sfum_3749	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Sfum_3750	COG0673	inositol 2-dehydrogenase activity
Sfum_3751	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Sfum_3752	COG1519	Transferase
Sfum_3762	COG1116	anion transmembrane transporter activity
Sfum_3765	COG2204	response regulator
Sfum_3766	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Sfum_3767	COG1605	Chorismate mutase
Sfum_3767	COG0287	Prephenate dehydrogenase
Sfum_3769	COG0653	protein targeting
Sfum_3776	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Sfum_3779	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Sfum_3789	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Sfum_3790	COG0358	DNA primase activity
Sfum_3849	COG2815	serine threonine protein kinase
Sfum_3849	COG0515	serine threonine protein kinase
Sfum_3870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Sfum_3872	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Sfum_3872	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Sfum_3874	COG0492	ferredoxin-NADP+ reductase activity
Sfum_3877	COG1595	DNA-templated transcription, initiation
Sfum_3891	COG2033	superoxide reductase activity
Sfum_3896	COG0538	isocitrate dehydrogenase activity
Sfum_3897	COG2264	protein methyltransferase activity
Sfum_3899	COG0277	FAD linked oxidase domain protein
Sfum_3900	COG0765	amino acid transport
Sfum_3901	COG1126	abc transporter atp-binding protein
Sfum_3902	COG4160	amino acid transport
Sfum_3904	COG0251	oxidation-reduction process
Sfum_3907	COG0438	transferase activity, transferring glycosyl groups
Sfum_3911	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Sfum_3912	COG3527	Alpha-acetolactate decarboxylase
Sfum_3914	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Sfum_3915	COG2379	hydroxypyruvate reductase
Sfum_3926	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
Sfum_3927	COG0644	oxidoreductase
Sfum_3928	COG0644	oxidoreductase
Sfum_3931	COG1960	acyl-CoA dehydrogenase activity
Sfum_3934	COG3829	transcription factor binding
Sfum_3934	COG3290	protein histidine kinase activity
Sfum_3938	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Sfum_3938	COG4651	solute:proton antiporter activity
Sfum_3945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sfum_3950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sfum_3955	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
Sfum_3988	COG1132	(ABC) transporter
Sfum_3991	COG3290	protein histidine kinase activity
Sfum_3992	COG4565	transcriptional regulatory protein
Sfum_3993	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Sfum_4003	COG0668	transmembrane transport
Sfum_4004	COG0131	Imidazoleglycerol-phosphate dehydratase
Sfum_4011	COG0375	protein maturation
Sfum_4013	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Sfum_4014	COG0409	Hydrogenase expression formation protein
Sfum_4015	COG0309	Hydrogenase expression formation protein (HypE)
Sfum_4017	COG2223	nitrite transmembrane transporter activity
Sfum_4019	COG0488	(ABC) transporter
Sfum_4023	COG0012	GTP binding
Sfum_4025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Sfum_4027	COG2208	phosphoserine phosphatase activity
Sfum_4027	COG2770	Histidine kinase
Sfum_4031	COG1132	(ABC) transporter
Sfum_4033	COG1366	Belongs to the anti-sigma-factor antagonist family
Sfum_4039	COG1047	Peptidyl-prolyl cis-trans
Sfum_4042	COG2221	Nitrite and sulphite reductase 4Fe-4S
Sfum_4043	COG2221	Nitrite and sulphite reductase 4Fe-4S
Sfum_4044	COG1797	cobyrinic acid a,c-diamide synthase activity
Sfum_4045	COG2920	part of a sulfur-relay system
Sfum_4046	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
Sfum_4050	COG1253	flavin adenine dinucleotide binding
Sfum_4051	COG0215	cysteine-tRNA ligase activity
Sfum_4052	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Sfum_4053	COG0436	Aminotransferase
Sfum_4056	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Sfum_4057	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Sfum_4058	COG0123	including yeast histone deacetylase and acetoin utilization protein
Sfum_4060	COG1077	Cell shape determining protein MreB Mrl
Sfum_4061	COG1686	Belongs to the peptidase S11 family
Sfum_4066	COG0463	Glycosyl transferase, family 2
Sfum_4070	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sfum_4073	COG0410	ABC transporter
Sfum_4077	COG1489	DNA binding
Sfum_4080	COG1872	DUF167
Sfum_4095	COG1053	succinate dehydrogenase
Sfum_4096	COG3118	belongs to the thioredoxin family
Sfum_4100	COG1469	GTP cyclohydrolase I activity
Sfum_4102	COG1181	Belongs to the D-alanine--D-alanine ligase family