locus-tag	class	description
Sgly_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Sgly_0002	COG0592	DNA-directed DNA polymerase activity
Sgly_0005	COG0187	DNA topoisomerase II activity
Sgly_0006	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Sgly_0007	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Sgly_0008	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Sgly_0010	COG0590	tRNA wobble adenosine to inosine editing
Sgly_0012	COG1373	ATPase (AAA superfamily
Sgly_0016	COG0582	viral genome integration into host DNA
Sgly_0018	COG2337	Toxic component of a toxin-antitoxin (TA) module
Sgly_0021	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Sgly_0023	COG2217	Heavy metal translocating P-type atpase
Sgly_0030	COG0798	PFAM Bile acid sodium symporter
Sgly_0040	COG1196	nuclear chromosome segregation
Sgly_0040	COG0741	lytic transglycosylase activity
Sgly_0040	COG0739	heme binding
Sgly_0048	COG0582	viral genome integration into host DNA
Sgly_0050	COG0582	viral genome integration into host DNA
Sgly_0068	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Sgly_0072	COG2088	sporulation resulting in formation of a cellular spore
Sgly_0083	COG0582	viral genome integration into host DNA
Sgly_0085	COG3177	Filamentation induced by cAMP protein fic
Sgly_0086	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Sgly_0087	COG0210	DNA helicase
Sgly_0097	COG3177	Filamentation induced by cAMP protein fic
Sgly_0099	COG1595	DNA-templated transcription, initiation
Sgly_0103	COG1191	sigma factor activity
Sgly_0110	COG1131	(ABC) transporter
Sgly_0116	COG1918	ferrous iron import across plasma membrane
Sgly_0118	COG2203	Gaf domain
Sgly_0118	COG2199	diguanylate cyclase activity
Sgly_0121	COG0840	transmembrane signaling receptor activity
Sgly_0123	COG0651	ATP synthesis coupled electron transport
Sgly_0124	COG0650	Formate hydrogenlyase subunit 4
Sgly_0126	COG0651	ATP synthesis coupled electron transport
Sgly_0127	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Sgly_0127	COG3261	NADH dehydrogenase
Sgly_0128	COG3260	NADH ubiquinone oxidoreductase 20
Sgly_0130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Sgly_0131	COG0573	inorganic phosphate transmembrane transporter activity
Sgly_0132	COG0581	inorganic phosphate transmembrane transporter activity
Sgly_0133	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Sgly_0134	COG0704	Plays a role in the regulation of phosphate uptake
Sgly_0135	COG0745	RESPONSE REGULATOR receiver
Sgly_0137	COG3300	MHYT domain
Sgly_0137	COG5001	Diguanylate cyclase
Sgly_0138	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Sgly_0140	COG0741	lytic transglycosylase activity
Sgly_0142	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Sgly_0143	COG1131	(ABC) transporter
Sgly_0144	COG1131	(ABC) transporter
Sgly_0145	COG0842	Transport permease protein
Sgly_0148	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Sgly_0149	COG0248	Ppx GppA phosphatase
Sgly_0150	COG0667	Aldo Keto reductase
Sgly_0152	COG1233	COG1233 Phytoene dehydrogenase and related
Sgly_0155	COG0701	Predicted permease
Sgly_0156	COG0523	cobalamin synthesis protein
Sgly_0157	COG0735	belongs to the Fur family
Sgly_0158	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Sgly_0159	COG1121	(ABC) transporter
Sgly_0160	COG0803	Belongs to the bacterial solute-binding protein 9 family
Sgly_0161	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Sgly_0162	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Sgly_0165	COG1013	pyruvate-flavodoxin oxidoreductase activity
Sgly_0165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Sgly_0165	COG0674	pyruvate-flavodoxin oxidoreductase activity
Sgly_0165	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Sgly_0168	COG1982	Orn Lys Arg decarboxylase major
Sgly_0169	COG0470	DNA polymerase III
Sgly_0170	COG1774	PSP1 C-terminal conserved region
Sgly_0171	COG4467	Involved in initiation control of chromosome replication
Sgly_0172	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Sgly_0173	COG2002	toxin-antitoxin pair type II binding
Sgly_0174	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sgly_0174	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sgly_0175	COG0084	hydrolase, TatD family'
Sgly_0184	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
Sgly_0186	COG0840	transmembrane signaling receptor activity
Sgly_0188	COG4242	Belongs to the peptidase S51 family
Sgly_0189	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Sgly_0189	COG0189	ligase activity
Sgly_0191	COG1802	Transcriptional regulator
Sgly_0192	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Sgly_0195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Sgly_0199	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Sgly_0200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Sgly_0201	COG2002	toxin-antitoxin pair type II binding
Sgly_0202	COG3956	TIGRFAM MazG family protein
Sgly_0204	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Sgly_0210	COG0037	tRNA processing
Sgly_0215	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Sgly_0216	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Sgly_0217	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Sgly_0218	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Sgly_0221	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Sgly_0222	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Sgly_0225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Sgly_0227	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Sgly_0229	COG2195	Cleaves the N-terminal amino acid of tripeptides
Sgly_0231	COG1215	transferase activity, transferring glycosyl groups
Sgly_0234	COG2814	Major facilitator Superfamily
Sgly_0242	COG3949	Membrane
Sgly_0245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Sgly_0246	COG3481	metal-dependent phosphohydrolase, HD sub domain
Sgly_0247	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Sgly_0249	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Sgly_0250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Sgly_0255	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Sgly_0256	COG0826	peptidase U32
Sgly_0257	COG1193	negative regulation of DNA recombination
Sgly_0259	COG1309	transcriptional regulator
Sgly_0260	COG5002	protein histidine kinase activity
Sgly_0261	COG0745	RESPONSE REGULATOR receiver
Sgly_0262	COG4499	WXG100 protein secretion system (Wss), protein YukC
Sgly_0262	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Sgly_0263	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Sgly_0264	COG0235	Class ii aldolase
Sgly_0268	COG3546	catalase activity
Sgly_0270	COG3458	cephalosporin-C deacetylase activity
Sgly_0271	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Sgly_0272	COG3152	Membrane
Sgly_0275	COG1136	(ABC) transporter
Sgly_0277	COG1136	(ABC) transporter
Sgly_0279	COG1785	Belongs to the alkaline phosphatase family
Sgly_0283	COG1132	(ABC) transporter
Sgly_0289	COG1331	Highly conserved protein containing a thioredoxin domain
Sgly_0295	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Sgly_0296	COG0542	response to heat
Sgly_0297	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Sgly_0299	COG4956	integral membrane protein (PIN domain superfamily)
Sgly_0302	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Sgly_0304	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
Sgly_0306	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Sgly_0310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Sgly_0314	COG1444	tRNA N-acetyltransferase activity
Sgly_0316	COG3773	Cell wall hydrolase
Sgly_0319	COG2002	toxin-antitoxin pair type II binding
Sgly_0368	COG3655	Transcriptional regulator
Sgly_0369	COG0658	competence protein
Sgly_0369	COG2333	competence protein COMEC
Sgly_0374	COG2226	methyltransferase
Sgly_0375	COG0840	transmembrane signaling receptor activity
Sgly_0376	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Sgly_0377	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Sgly_0378	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Sgly_0379	COG0250	Participates in transcription elongation, termination and antitermination
Sgly_0380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Sgly_0382	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Sgly_0384	COG0085	RNA polymerase activity
Sgly_0385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Sgly_0386	COG1358	cellular component organization or biogenesis
Sgly_0389	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Sgly_0392	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Sgly_0393	COG0088	Forms part of the polypeptide exit tunnel
Sgly_0394	COG0089	rRNA binding
Sgly_0397	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Sgly_0398	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Sgly_0399	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Sgly_0402	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Sgly_0403	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Sgly_0408	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Sgly_0410	COG0200	Binds to the 23S rRNA
Sgly_0411	COG0201	protein transport
Sgly_0414	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Sgly_0416	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Sgly_0420	COG0203	ribosomal protein L17
Sgly_0421	COG0101	tRNA pseudouridine synthase activity
Sgly_0425	COG0861	Integral membrane protein TerC family
Sgly_0426	COG0589	response to stress
Sgly_0427	COG0860	N-Acetylmuramoyl-L-alanine amidase
Sgly_0428	COG1473	amidohydrolase
Sgly_0429	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Sgly_0430	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Sgly_0431	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Sgly_0432	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Sgly_0433	COG0505	Belongs to the CarA family
Sgly_0434	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Sgly_0435	COG0436	Aminotransferase
Sgly_0438	COG1983	PspC domain protein
Sgly_0443	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Sgly_0445	COG2059	Chromate
Sgly_0446	COG2059	Chromate
Sgly_0447	COG0501	Belongs to the peptidase M48B family
Sgly_0448	COG0861	Integral membrane protein TerC family
Sgly_0450	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
Sgly_0451	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Sgly_0454	COG0681	Belongs to the peptidase S26 family
Sgly_0457	COG2155	Conserved Protein
Sgly_0459	COG3328	transposase activity
Sgly_0461	COG0436	Aminotransferase
Sgly_0462	COG1191	sigma factor activity
Sgly_0468	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Sgly_0469	COG4149	molybdate abc transporter
Sgly_0470	COG0725	ABC transporter, periplasmic molybdate-binding protein
Sgly_0471	COG1910	domain protein
Sgly_0474	COG0564	pseudouridine synthase activity
Sgly_0476	COG5002	protein histidine kinase activity
Sgly_0477	COG0745	RESPONSE REGULATOR receiver
Sgly_0482	COG1694	Mazg nucleotide pyrophosphohydrolase
Sgly_0483	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Sgly_0485	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Sgly_0486	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Sgly_0487	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Sgly_0488	COG0517	IMP dehydrogenase activity
Sgly_0488	COG4175	Glycine betaine
Sgly_0489	COG4176	ABC-type proline glycine betaine transport system permease component
Sgly_0490	COG2113	Glycine betaine
Sgly_0491	COG0038	chloride channel
Sgly_0492	COG0569	domain protein
Sgly_0493	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Sgly_0494	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Sgly_0495	COG2720	vancomycin resistance protein
Sgly_0498	COG0745	RESPONSE REGULATOR receiver
Sgly_0499	COG5002	protein histidine kinase activity
Sgly_0500	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Sgly_0501	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Sgly_0502	COG4208	sulfate ABC transporter
Sgly_0505	COG0175	sulfate reduction
Sgly_0509	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Sgly_0511	COG2221	Nitrite and sulphite reductase 4Fe-4S
Sgly_0512	COG0425	Belongs to the sulfur carrier protein TusA family
Sgly_0516	COG1648	precorrin-2 dehydrogenase activity
Sgly_0516	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Sgly_0536	COG4383	Mu-like prophage protein gp29
Sgly_0537	COG2369	cell adhesion
Sgly_0540	COG4397	Mu-like prophage major head subunit gpT
Sgly_0569	COG1215	transferase activity, transferring glycosyl groups
Sgly_0570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Sgly_0571	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Sgly_0572	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Sgly_0575	COG2747	anti-sigma28 factor FlgM
Sgly_0577	COG4786	Flagellar basal body rod
Sgly_0577	COG1256	bacterial-type flagellum assembly
Sgly_0580	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Sgly_0581	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Sgly_0583	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Sgly_0584	COG0463	Glycosyl transferase, family 2
Sgly_0584	COG0457	Tetratricopeptide repeat
Sgly_0585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Sgly_0588	COG1516	flagellar protein fliS
Sgly_0590	COG0643	Histidine kinase
Sgly_0590	COG2198	Histidine kinase
Sgly_0591	COG0835	chemotaxis
Sgly_0592	COG2201	protein-glutamate methylesterase activity
Sgly_0593	COG1558	bacterial-type flagellum-dependent cell motility
Sgly_0595	COG1766	The M ring may be actively involved in energy transduction
Sgly_0596	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Sgly_0598	COG1157	protein secretion by the type III secretion system
Sgly_0602	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Sgly_0603	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Sgly_0603	COG1776	CheC inhibitor of MCP methylation
Sgly_0604	COG2201	protein-glutamate methylesterase activity
Sgly_0606	COG1338	Plays a role in the flagellum-specific transport system
Sgly_0607	COG1987	bacterial-type flagellum assembly
Sgly_0608	COG1684	flagellar biosynthetic protein fliR
Sgly_0609	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Sgly_0610	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Sgly_0611	COG1419	protein localization to endoplasmic reticulum
Sgly_0612	COG0455	bacterial-type flagellum organization
Sgly_0614	COG1776	CheC inhibitor of MCP methylation
Sgly_0617	COG1191	sigma factor activity
Sgly_0619	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Sgly_0620	COG4786	Flagellar basal body rod
Sgly_0621	COG4786	Flagellar basal body rod
Sgly_0622	COG1815	bacterial-type flagellum-dependent cell motility
Sgly_0626	COG4862	establishment of competence for transformation
Sgly_0628	COG1316	TRANSCRIPTIONal
Sgly_0632	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Sgly_0634	COG2221	Nitrite and sulphite reductase 4Fe-4S
Sgly_0635	COG0735	belongs to the Fur family
Sgly_0639	COG2001	Belongs to the MraZ family
Sgly_0642	COG0768	penicillin binding
Sgly_0643	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Sgly_0644	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Sgly_0647	COG0772	Belongs to the SEDS family
Sgly_0648	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Sgly_0649	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Sgly_0650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Sgly_0651	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Sgly_0652	COG3856	small basic protein
Sgly_0653	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Sgly_0655	COG1191	sigma factor activity
Sgly_0656	COG1191	sigma factor activity
Sgly_0657	COG1873	PFAM PRC-barrel domain
Sgly_0660	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Sgly_0661	COG1799	cell septum assembly
Sgly_0667	COG0840	transmembrane signaling receptor activity
Sgly_0668	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Sgly_0671	COG4869	propanediol catabolic process
Sgly_0673	COG0564	pseudouridine synthase activity
Sgly_0674	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Sgly_0676	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Sgly_0677	COG0505	Belongs to the CarA family
Sgly_0679	COG0543	2 iron, 2 sulfur cluster binding
Sgly_0680	COG0167	dihydroorotate dehydrogenase activity
Sgly_0682	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Sgly_0686	COG5002	protein histidine kinase activity
Sgly_0688	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Sgly_0690	COG1561	YicC-like family, N-terminal region
Sgly_0691	COG2052	Domain of unknown function (DUF370)
Sgly_0692	COG0194	GDP metabolic process
Sgly_0694	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Sgly_0696	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Sgly_0700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Sgly_0701	COG2210	Belongs to the sulfur carrier protein TusA family
Sgly_0702	COG0372	Belongs to the citrate synthase family
Sgly_0705	COG2720	vancomycin resistance protein
Sgly_0707	COG4496	protein, YerC YecD
Sgly_0708	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Sgly_0711	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Sgly_0713	COG0131	Imidazoleglycerol-phosphate dehydratase
Sgly_0717	COG0140	phosphoribosyl-ATP diphosphatase activity
Sgly_0717	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Sgly_0719	COG0210	DNA helicase
Sgly_0721	COG0837	glucose binding
Sgly_0722	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Sgly_0727	COG0154	amidase activity
Sgly_0728	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Sgly_0729	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Sgly_0737	COG3328	transposase activity
Sgly_0740	COG4585	Histidine kinase
Sgly_0741	COG2197	response regulator
Sgly_0787	COG3778	Protein conserved in bacteria
Sgly_0799	COG4978	Transcriptional regulator
Sgly_0799	COG0789	Transcriptional regulator
Sgly_0804	COG1116	anion transmembrane transporter activity
Sgly_0806	COG3665	Urea carboxylase-associated protein
Sgly_0807	COG0439	Biotin carboxylase
Sgly_0809	COG1268	BioY protein
Sgly_0810	COG1122	ATPase activity
Sgly_0811	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Sgly_0816	COG4942	peptidase
Sgly_0822	COG1595	DNA-templated transcription, initiation
Sgly_0829	COG2226	methyltransferase
Sgly_0830	COG1131	(ABC) transporter
Sgly_0837	COG2197	response regulator
Sgly_0838	COG4585	Histidine kinase
Sgly_0840	COG0142	geranyltranstransferase activity
Sgly_0842	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Sgly_0852	COG3290	protein histidine kinase activity
Sgly_0855	COG3279	Response regulator of the LytR AlgR family
Sgly_0856	COG0644	oxidoreductase
Sgly_0857	COG0463	Glycosyl transferase, family 2
Sgly_0859	COG0535	radical SAM domain protein
Sgly_0860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sgly_0865	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Sgly_0865	COG0662	Cupin 2, conserved barrel domain protein
Sgly_0869	COG1136	(ABC) transporter
Sgly_0869	COG0577	efflux transmembrane transporter activity
Sgly_0875	COG1201	RNA secondary structure unwinding
Sgly_0881	COG3279	Response regulator of the LytR AlgR family
Sgly_0883	COG0745	RESPONSE REGULATOR receiver
Sgly_0884	COG5002	protein histidine kinase activity
Sgly_0885	COG1368	sulfuric ester hydrolase activity
Sgly_0889	COG2249	NAD(P)H dehydrogenase (quinone) activity
Sgly_0894	COG2814	Major facilitator Superfamily
Sgly_0906	COG1518	maintenance of DNA repeat elements
Sgly_0909	COG2873	o-acetylhomoserine
Sgly_0914	COG2602	Beta-lactamase
Sgly_0914	COG4219	Peptidase M56
Sgly_0916	COG1181	Belongs to the D-alanine--D-alanine ligase family
Sgly_0919	COG3344	reverse transcriptase
Sgly_0923	COG2094	Belongs to the DNA glycosylase MPG family
Sgly_0925	COG1473	amidohydrolase
Sgly_0928	COG0626	cystathionine gamma-synthase activity
Sgly_0932	COG3615	Tellurite resistance protein tehB
Sgly_0932	COG0500	methyltransferase
Sgly_0935	COG1132	(ABC) transporter
Sgly_0936	COG1132	(ABC) transporter
Sgly_0939	COG1131	(ABC) transporter
Sgly_0942	COG3214	Protein conserved in bacteria
Sgly_0955	COG1619	proteins homologs of microcin C7 resistance protein MccF
Sgly_0956	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Sgly_0957	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Sgly_0958	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Sgly_0963	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Sgly_0964	COG1846	Transcriptional regulator
Sgly_0967	COG0347	Belongs to the P(II) protein family
Sgly_0968	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sgly_0969	COG1116	anion transmembrane transporter activity
Sgly_0971	COG0010	Belongs to the arginase family
Sgly_0973	COG3835	regulator
Sgly_0977	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Sgly_0978	COG0830	nickel cation binding
Sgly_0982	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Sgly_0983	COG0577	efflux transmembrane transporter activity
Sgly_0983	COG1136	(ABC) transporter
Sgly_0984	COG1136	(ABC) transporter
Sgly_0986	COG5002	protein histidine kinase activity
Sgly_0987	COG0745	RESPONSE REGULATOR receiver
Sgly_0989	COG1393	Belongs to the ArsC family
Sgly_0997	COG0500	methyltransferase
Sgly_0999	COG3335	DDE superfamily endonuclease
Sgly_1008	COG4895	conserved protein (DUF2196)
Sgly_1010	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Sgly_1011	COG0242	peptide deformylase activity
Sgly_1012	COG1132	(ABC) transporter
Sgly_1013	COG1132	(ABC) transporter
Sgly_1016	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sgly_1018	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Sgly_1022	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Sgly_1024	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Sgly_1036	COG0577	efflux transmembrane transporter activity
Sgly_1036	COG1136	(ABC) transporter
Sgly_1040	COG1136	(ABC) transporter
Sgly_1040	COG0577	efflux transmembrane transporter activity
Sgly_1049	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Sgly_1058	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Sgly_1058	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Sgly_1067	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Sgly_1067	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Sgly_1077	COG0564	pseudouridine synthase activity
Sgly_1080	COG1595	DNA-templated transcription, initiation
Sgly_1082	COG0515	serine threonine protein kinase
Sgly_1086	COG0745	RESPONSE REGULATOR receiver
Sgly_1087	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Sgly_1088	COG1749	Flagellar hook protein flgE
Sgly_1089	COG4786	Flagellar basal body rod
Sgly_1089	COG1256	bacterial-type flagellum assembly
Sgly_1090	COG4786	Flagellar basal body rod
Sgly_1090	COG1256	bacterial-type flagellum assembly
Sgly_1092	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Sgly_1094	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Sgly_1097	COG5002	protein histidine kinase activity
Sgly_1098	COG0745	RESPONSE REGULATOR receiver
Sgly_1102	COG2247	cell wall binding repeat
Sgly_1102	COG2385	sporulation resulting in formation of a cellular spore
Sgly_1105	COG0765	amino acid transport
Sgly_1106	COG0765	amino acid transport
Sgly_1107	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sgly_1109	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sgly_1110	COG1140	nitrate reductase beta subunit
Sgly_1112	COG0446	pyridine nucleotide-disulphide oxidoreductase
Sgly_1112	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Sgly_1114	COG1126	abc transporter atp-binding protein
Sgly_1115	COG1253	flavin adenine dinucleotide binding
Sgly_1119	COG2766	serine protein kinase
Sgly_1121	COG2719	SpoVR family
Sgly_1125	COG2814	Major facilitator Superfamily
Sgly_1126	COG2030	dehydratase
Sgly_1129	COG0318	PFAM AMP-dependent synthetase and ligase
Sgly_1132	COG1960	acyl-CoA dehydrogenase activity
Sgly_1133	COG0644	oxidoreductase
Sgly_1136	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Sgly_1138	COG1012	belongs to the aldehyde dehydrogenase family
Sgly_1139	COG0513	Belongs to the DEAD box helicase family
Sgly_1140	COG1595	DNA-templated transcription, initiation
Sgly_1148	COG0745	RESPONSE REGULATOR receiver
Sgly_1149	COG2205	protein histidine kinase activity
Sgly_1150	COG1136	(ABC) transporter
Sgly_1151	COG0577	efflux transmembrane transporter activity
Sgly_1152	COG1309	transcriptional regulator
Sgly_1155	COG1335	isochorismatase
Sgly_1158	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Sgly_1164	COG1129	ABC transporter
Sgly_1168	COG3123	guanosine phosphorylase activity
Sgly_1173	COG2197	response regulator
Sgly_1174	COG0643	Histidine kinase
Sgly_1174	COG2198	Histidine kinase
Sgly_1175	COG0835	chemotaxis
Sgly_1177	COG2201	protein-glutamate methylesterase activity
Sgly_1178	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Sgly_1180	COG2201	protein-glutamate methylesterase activity
Sgly_1181	COG0840	transmembrane signaling receptor activity
Sgly_1182	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Sgly_1182	COG2199	diguanylate cyclase activity
Sgly_1187	COG2378	regulation of single-species biofilm formation
Sgly_1191	COG1136	(ABC) transporter
Sgly_1193	COG0745	RESPONSE REGULATOR receiver
Sgly_1199	COG0668	transmembrane transport
Sgly_1200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Sgly_1202	COG1033	growth of symbiont in host cell
Sgly_1202	COG2409	Drug exporters of the RND superfamily
Sgly_1206	COG0446	pyridine nucleotide-disulphide oxidoreductase
Sgly_1206	COG1902	pentaerythritol trinitrate reductase activity
Sgly_1207	COG1129	ABC transporter
Sgly_1213	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Sgly_1224	COG2378	regulation of single-species biofilm formation
Sgly_1229	COG1136	(ABC) transporter
Sgly_1229	COG4591	ABC-type transport system involved in lipoprotein release permease component
Sgly_1230	COG5002	protein histidine kinase activity
Sgly_1231	COG0745	RESPONSE REGULATOR receiver
Sgly_1232	COG1132	(ABC) transporter
Sgly_1235	COG1309	transcriptional regulator
Sgly_1236	COG1131	(ABC) transporter
Sgly_1246	COG1136	(ABC) transporter
Sgly_1248	COG0745	RESPONSE REGULATOR receiver
Sgly_1251	COG1131	(ABC) transporter
Sgly_1255	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Sgly_1258	COG0420	3'-5' exonuclease activity
Sgly_1259	COG0419	ATPase involved in DNA repair
Sgly_1261	COG1937	Protein conserved in bacteria
Sgly_1286	COG1131	(ABC) transporter
Sgly_1288	COG1595	DNA-templated transcription, initiation
Sgly_1293	COG1595	DNA-templated transcription, initiation
Sgly_1300	COG2378	regulation of single-species biofilm formation
Sgly_1302	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Sgly_1302	COG0426	domain, Protein
Sgly_1304	COG2378	regulation of single-species biofilm formation
Sgly_1309	COG1129	ABC transporter
Sgly_1315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Sgly_1317	COG1124	(ABC) transporter
Sgly_1319	COG0601	transmembrane transport
Sgly_1324	COG2226	methyltransferase
Sgly_1326	COG2835	tetraacyldisaccharide 4'-kinase activity
Sgly_1329	COG1122	ATPase activity
Sgly_1330	COG1122	ATPase activity
Sgly_1331	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Sgly_1335	COG3620	sequence-specific DNA binding
Sgly_1342	COG1120	ATPase activity
Sgly_1343	COG1609	Transcriptional regulator
Sgly_1343	COG2207	Transcriptional regulator
Sgly_1345	COG1132	(ABC) transporter
Sgly_1360	COG1131	(ABC) transporter
Sgly_1364	COG2807	transmembrane transport
Sgly_1368	COG5646	InterPro IPR014922
Sgly_1375	COG1454	alcohol dehydrogenase
Sgly_1379	COG0167	dihydroorotate dehydrogenase activity
Sgly_1379	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Sgly_1380	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Sgly_1382	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sgly_1390	COG1518	maintenance of DNA repeat elements
Sgly_1391	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Sgly_1394	COG2205	protein histidine kinase activity
Sgly_1395	COG0745	RESPONSE REGULATOR receiver
Sgly_1397	COG1136	(ABC) transporter
Sgly_1399	COG0386	Belongs to the glutathione peroxidase family
Sgly_1400	COG1846	Transcriptional regulator
Sgly_1403	COG2183	response to ionizing radiation
Sgly_1405	COG1131	(ABC) transporter
Sgly_1406	COG0753	catalase activity
Sgly_1406	COG0693	protein deglycase activity
Sgly_1408	COG0535	radical SAM domain protein
Sgly_1410	COG1316	TRANSCRIPTIONal
Sgly_1411	COG3706	GGDEF domain
Sgly_1411	COG0745	RESPONSE REGULATOR receiver
Sgly_1423	COG1342	Belongs to the UPF0251 family
Sgly_1424	COG0157	Belongs to the NadC ModD family
Sgly_1425	COG0025	NhaP-type Na H and K H
Sgly_1427	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Sgly_1428	COG2814	Major facilitator Superfamily
Sgly_1430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Sgly_1434	COG2873	o-acetylhomoserine
Sgly_1439	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Sgly_1440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sgly_1443	COG3177	Filamentation induced by cAMP protein fic
Sgly_1450	COG1131	(ABC) transporter
Sgly_1467	COG1253	flavin adenine dinucleotide binding
Sgly_1472	COG0641	radical SAM
Sgly_1473	COG2186	Transcriptional regulator
Sgly_1474	COG4988	ABC transporter
Sgly_1475	COG1132	(ABC) transporter
Sgly_1477	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Sgly_1478	COG1122	ATPase activity
Sgly_1484	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Sgly_1488	COG1120	ATPase activity
Sgly_1492	COG0450	alkyl hydroperoxide reductase
Sgly_1494	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Sgly_1496	COG1321	iron dependent repressor
Sgly_1497	COG0803	Belongs to the bacterial solute-binding protein 9 family
Sgly_1498	COG1121	(ABC) transporter
Sgly_1499	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Sgly_1500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Sgly_1501	COG0860	N-Acetylmuramoyl-L-alanine amidase
Sgly_1501	COG2247	cell wall binding repeat
Sgly_1502	COG3437	response regulator, receiver
Sgly_1505	COG3944	biosynthesis protein
Sgly_1507	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Sgly_1515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Sgly_1516	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Sgly_1520	COG0582	viral genome integration into host DNA
Sgly_1521	COG2217	Heavy metal translocating P-type atpase
Sgly_1522	COG0640	Transcriptional regulator
Sgly_1523	COG2247	cell wall binding repeat
Sgly_1523	COG0860	N-Acetylmuramoyl-L-alanine amidase
Sgly_1525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Sgly_1530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Sgly_1534	COG1132	(ABC) transporter
Sgly_1535	COG1132	(ABC) transporter
Sgly_1536	COG0583	DNA-binding transcription factor activity
Sgly_1537	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Sgly_1538	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sgly_1539	COG1116	anion transmembrane transporter activity
Sgly_1543	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Sgly_1544	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Sgly_1546	COG0789	Transcriptional regulator
Sgly_1550	COG0463	Glycosyl transferase, family 2
Sgly_1550	COG0457	Tetratricopeptide repeat
Sgly_1561	COG1028	Short-chain dehydrogenase reductase Sdr
Sgly_1566	COG0110	maltose O-acetyltransferase activity
Sgly_1577	COG1132	(ABC) transporter
Sgly_1580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sgly_1580	COG0723	plastoquinol--plastocyanin reductase activity
Sgly_1584	COG2199	diguanylate cyclase activity
Sgly_1584	COG2203	Gaf domain
Sgly_1585	COG0531	amino acid
Sgly_1586	COG0671	phosphoesterase, PA-phosphatase related
Sgly_1589	COG2326	polyphosphate kinase activity
Sgly_1590	COG1704	LemA family
Sgly_1592	COG4224	UPF0291 protein
Sgly_1593	COG0538	isocitrate dehydrogenase activity
Sgly_1594	COG2247	cell wall binding repeat
Sgly_1594	COG0860	N-Acetylmuramoyl-L-alanine amidase
Sgly_1596	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Sgly_1598	COG0517	IMP dehydrogenase activity
Sgly_1598	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Sgly_1599	COG0561	phosphatase activity
Sgly_1602	COG0463	Glycosyl transferase, family 2
Sgly_1603	COG0438	transferase activity, transferring glycosyl groups
Sgly_1604	COG1215	transferase activity, transferring glycosyl groups
Sgly_1609	COG5039	Polysaccharide pyruvyl transferase
Sgly_1614	COG3944	biosynthesis protein
Sgly_1615	COG0489	protein tyrosine kinase activity
Sgly_1617	COG0367	asparagine synthase
Sgly_1622	COG1132	(ABC) transporter
Sgly_1623	COG1408	metallophosphoesterase
Sgly_1626	COG0590	tRNA wobble adenosine to inosine editing
Sgly_1629	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Sgly_1630	COG1253	flavin adenine dinucleotide binding
Sgly_1632	COG1307	EDD domain protein, DegV family
Sgly_1633	COG2050	protein possibly involved in aromatic compounds catabolism
Sgly_1634	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Sgly_1635	COG1454	alcohol dehydrogenase
Sgly_1636	COG2814	Major facilitator Superfamily
Sgly_1639	COG1136	(ABC) transporter
Sgly_1640	COG0577	efflux transmembrane transporter activity
Sgly_1640	COG1136	(ABC) transporter
Sgly_1641	COG2247	cell wall binding repeat
Sgly_1641	COG0860	N-Acetylmuramoyl-L-alanine amidase
Sgly_1643	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Sgly_1644	COG0745	RESPONSE REGULATOR receiver
Sgly_1645	COG5002	protein histidine kinase activity
Sgly_1646	COG0463	Glycosyl transferase, family 2
Sgly_1649	COG0784	Response regulator, receiver
Sgly_1649	COG0835	chemotaxis
Sgly_1650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Sgly_1651	COG1592	Rubrerythrin
Sgly_1651	COG1773	rubredoxin
Sgly_1654	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Sgly_1655	COG0352	thiamine-phosphate diphosphorylase activity
Sgly_1658	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Sgly_1660	COG1131	(ABC) transporter
Sgly_1664	COG1136	(ABC) transporter
Sgly_1665	COG0577	efflux transmembrane transporter activity
Sgly_1670	COG0306	phosphate transporter
Sgly_1673	COG0735	belongs to the Fur family
Sgly_1674	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Sgly_1675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Sgly_1677	COG3874	Sporulation protein YtfJ
Sgly_1678	COG2715	membrane protein required for spore maturation
Sgly_1679	COG0700	Nucleoside recognition
Sgly_1680	COG1187	pseudouridine synthase activity
Sgly_1681	COG2186	Transcriptional regulator
Sgly_1682	COG2186	Transcriptional regulator
Sgly_1684	COG2081	HI0933 family
Sgly_1692	COG0539	negative regulation of cytoplasmic translation
Sgly_1692	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Sgly_1693	COG0772	Belongs to the SEDS family
Sgly_1695	COG1160	GTP binding
Sgly_1696	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Sgly_1697	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Sgly_1698	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Sgly_1699	COG4492	Belongs to the UPF0735 family
Sgly_1706	COG0598	Magnesium transport protein CorA
Sgly_1710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Sgly_1711	COG0805	protein transport
Sgly_1712	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Sgly_1713	COG0142	geranyltranstransferase activity
Sgly_1715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Sgly_1720	COG0726	polysaccharide deacetylase
Sgly_1723	COG0163	prenyltransferase activity
Sgly_1729	COG0564	pseudouridine synthase activity
Sgly_1733	COG0436	Aminotransferase
Sgly_1739	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Sgly_1740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Sgly_1741	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Sgly_1744	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Sgly_1748	COG1131	(ABC) transporter
Sgly_1751	COG1309	transcriptional regulator
Sgly_1758	COG1388	LysM domain
Sgly_1760	COG1181	Belongs to the D-alanine--D-alanine ligase family
Sgly_1762	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Sgly_1763	COG0464	growth
Sgly_1765	COG1923	regulation of RNA biosynthetic process
Sgly_1766	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Sgly_1767	COG2136	Putative SAM-dependent methyltransferase
Sgly_1767	COG2521	methyltransferase
Sgly_1768	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Sgly_1771	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Sgly_1774	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Sgly_1775	COG1307	EDD domain protein, DegV family
Sgly_1776	COG0455	bacterial-type flagellum organization
Sgly_1780	COG1691	(AIR) carboxylase
Sgly_1782	COG1363	Peptidase, m42
Sgly_1784	COG0768	penicillin binding
Sgly_1786	COG0457	Tetratricopeptide repeat
Sgly_1786	COG0705	Rhomboid family
Sgly_1788	COG1615	UPF0182 protein
Sgly_1789	COG2197	response regulator
Sgly_1791	COG1484	DNA-dependent DNA replication
Sgly_1792	COG3935	DnaD domain protein
Sgly_1794	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Sgly_1798	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Sgly_1798	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Sgly_1800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Sgly_1800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Sgly_1806	COG0778	Nitroreductase
Sgly_1808	COG1131	(ABC) transporter
Sgly_1809	COG1725	Transcriptional regulator
Sgly_1811	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Sgly_1813	COG1132	(ABC) transporter
Sgly_1815	COG0747	negative chemotaxis
Sgly_1816	COG1124	(ABC) transporter
Sgly_1818	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sgly_1819	COG0601	transmembrane transport
Sgly_1820	COG2207	Transcriptional regulator
Sgly_1820	COG1917	Cupin 2, conserved barrel domain protein
Sgly_1821	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Sgly_1822	COG0542	response to heat
Sgly_1823	COG0484	heat shock protein binding
Sgly_1824	COG2755	lipolytic protein G-D-S-L family
Sgly_1824	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Sgly_1825	COG0745	RESPONSE REGULATOR receiver
Sgly_1826	COG5002	protein histidine kinase activity
Sgly_1830	COG0347	Belongs to the P(II) protein family
Sgly_1831	COG0668	transmembrane transport
Sgly_1834	COG2962	Rard protein
Sgly_1835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Sgly_1841	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Sgly_1842	COG0726	polysaccharide deacetylase
Sgly_1843	COG0133	tryptophan synthase activity
Sgly_1844	COG2721	sulfolactate sulfo-lyase activity
Sgly_1845	COG2721	sulfolactate sulfo-lyase activity
Sgly_1846	COG0367	asparagine synthase
Sgly_1849	COG2323	membrane
Sgly_1851	COG1295	ribonuclease BN
Sgly_1853	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Sgly_1855	COG0180	Tryptophanyl-tRNA synthetase
Sgly_1856	COG0617	tRNA 3'-terminal CCA addition
Sgly_1859	COG0697	spore germination
Sgly_1861	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Sgly_1863	COG1366	Belongs to the anti-sigma-factor antagonist family
Sgly_1864	COG2172	sigma factor antagonist activity
Sgly_1866	COG1686	Belongs to the peptidase S11 family
Sgly_1869	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Sgly_1871	COG4974	Belongs to the 'phage' integrase family
Sgly_1872	COG1300	Membrane
Sgly_1873	COG0494	nUDIX hydrolase
Sgly_1874	COG0745	RESPONSE REGULATOR receiver
Sgly_1875	COG0750	zinc metalloprotease
Sgly_1880	COG1216	Glycosyl transferase, family 2
Sgly_1881	COG0497	DNA recombination
Sgly_1884	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Sgly_1885	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Sgly_1886	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Sgly_1887	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
Sgly_1889	COG1722	exodeoxyribonuclease VII activity
Sgly_1890	COG1570	exodeoxyribonuclease VII activity
Sgly_1891	COG3404	Formiminotransferase-cyclodeaminase
Sgly_1892	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Sgly_1900	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Sgly_1903	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Sgly_1904	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Sgly_1908	COG1302	Protein conserved in bacteria
Sgly_1917	COG3854	ATPases associated with a variety of cellular activities
Sgly_1919	COG0006	proline dipeptidase activity
Sgly_1925	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Sgly_1926	COG2165	general secretion pathway protein
Sgly_1928	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Sgly_1932	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Sgly_1934	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Sgly_1936	COG1191	sigma factor activity
Sgly_1942	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Sgly_1943	COG3906	Belongs to the UPF0473 family
Sgly_1946	COG4472	Bacterial protein of unknown function (DUF965)
Sgly_1947	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Sgly_1948	COG0628	permease
Sgly_1951	COG0822	iron-sulfur transferase activity
Sgly_1953	COG1959	2 iron, 2 sulfur cluster binding
Sgly_1960	COG0322	excinuclease ABC activity
Sgly_1961	COG0739	heme binding
Sgly_1963	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Sgly_1965	COG1164	Oligoendopeptidase f
Sgly_1967	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Sgly_1969	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Sgly_1971	COG0791	NLP P60 protein
Sgly_1971	COG1388	LysM domain
Sgly_1972	COG1368	sulfuric ester hydrolase activity
Sgly_1976	COG3328	transposase activity
Sgly_1980	COG0789	Transcriptional regulator
Sgly_1983	COG3655	Transcriptional regulator
Sgly_1986	COG2608	mercury ion transmembrane transporter activity
Sgly_1987	COG2217	Heavy metal translocating P-type atpase
Sgly_1988	COG0488	(ABC) transporter
Sgly_1992	COG2261	transglycosylase associated protein
Sgly_1994	COG1136	(ABC) transporter
Sgly_1995	COG1136	(ABC) transporter
Sgly_1995	COG0577	efflux transmembrane transporter activity
Sgly_1996	COG3706	GGDEF domain
Sgly_1996	COG2203	Gaf domain
Sgly_1996	COG4251	negative regulation of phosphorylation
Sgly_1996	COG5001	Diguanylate cyclase
Sgly_2000	COG0393	Putative heavy-metal-binding
Sgly_2003	COG1131	(ABC) transporter
Sgly_2006	COG0024	Methionine aminopeptidase
Sgly_2019	COG2226	methyltransferase
Sgly_2020	COG1028	Short-chain dehydrogenase reductase Sdr
Sgly_2021	COG2996	Protein conserved in bacteria
Sgly_2022	COG0551	DNA topoisomerase type I activity
Sgly_2022	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Sgly_2028	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Sgly_2030	COG1139	Iron-sulfur cluster binding protein
Sgly_2039	COG0463	Glycosyl transferase, family 2
Sgly_2039	COG0457	Tetratricopeptide repeat
Sgly_2040	COG3459	Glycosyltransferase 36 associated
Sgly_2043	COG3328	transposase activity
Sgly_2047	COG1595	DNA-templated transcription, initiation
Sgly_2051	COG0409	Hydrogenase expression formation protein
Sgly_2054	COG0375	protein maturation
Sgly_2056	COG0649	NAD binding
Sgly_2058	COG3260	NADH ubiquinone oxidoreductase 20
Sgly_2059	COG0650	Formate hydrogenlyase subunit 4
Sgly_2061	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Sgly_2062	COG2244	polysaccharide biosynthetic process
Sgly_2065	COG0302	gtp cyclohydrolase
Sgly_2069	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Sgly_2072	COG0849	cell division
Sgly_2073	COG0205	6-phosphofructokinase activity
Sgly_2074	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Sgly_2080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Sgly_2081	COG1595	DNA-templated transcription, initiation
Sgly_2084	COG0739	heme binding
Sgly_2089	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Sgly_2090	COG0745	RESPONSE REGULATOR receiver
Sgly_2091	COG1141	Ferredoxin
Sgly_2094	COG1183	phosphatidylcholine synthase activity
Sgly_2095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Sgly_2095	COG1199	ATP-dependent helicase activity
Sgly_2097	COG2257	FlhB HrpN YscU SpaS Family
Sgly_2101	COG1937	Protein conserved in bacteria
Sgly_2102	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Sgly_2104	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Sgly_2105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sgly_2106	COG1490	D-aminoacyl-tRNA deacylase activity
Sgly_2107	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Sgly_2108	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Sgly_2108	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Sgly_2111	COG0440	acetolactate synthase activity
Sgly_2112	COG0028	Belongs to the TPP enzyme family
Sgly_2113	COG1234	tRNA 3'-trailer cleavage
Sgly_2114	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Sgly_2115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Sgly_2116	COG1862	Preprotein translocase
Sgly_2119	COG2385	sporulation resulting in formation of a cellular spore
Sgly_2121	COG0632	four-way junction helicase activity
Sgly_2123	COG0217	transcriptional regulatory protein
Sgly_2124	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Sgly_2125	COG3177	Filamentation induced by cAMP protein fic
Sgly_2126	COG1132	(ABC) transporter
Sgly_2127	COG1132	(ABC) transporter
Sgly_2128	COG0747	negative chemotaxis
Sgly_2133	COG2207	Transcriptional regulator
Sgly_2135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Sgly_2137	COG2207	Transcriptional regulator
Sgly_2146	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Sgly_2147	COG1116	anion transmembrane transporter activity
Sgly_2148	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sgly_2149	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Sgly_2150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Sgly_2152	COG0473	3-isopropylmalate dehydrogenase activity
Sgly_2153	COG0066	3-isopropylmalate dehydratase activity
Sgly_2154	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Sgly_2155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Sgly_2157	COG0440	acetolactate synthase activity
Sgly_2158	COG0028	Belongs to the TPP enzyme family
Sgly_2160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Sgly_2161	COG0460	homoserine dehydrogenase
Sgly_2163	COG0741	lytic transglycosylase activity
Sgly_2163	COG0739	heme binding
Sgly_2163	COG1196	nuclear chromosome segregation
Sgly_2164	COG0237	dephospho-CoA kinase activity
Sgly_2166	COG0488	(ABC) transporter
Sgly_2170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Sgly_2171	COG1739	Uncharacterized protein family UPF0029
Sgly_2174	COG0517	IMP dehydrogenase activity
Sgly_2175	COG0004	ammonium transporteR
Sgly_2176	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Sgly_2177	COG2226	methyltransferase
Sgly_2183	COG5557	Pfam Polysulphide reductase, NrfD
Sgly_2184	COG3064	Membrane
Sgly_2184	COG0437	4 iron, 4 sulfur cluster binding
Sgly_2186	COG5557	Pfam Polysulphide reductase, NrfD
Sgly_2187	COG3064	Membrane
Sgly_2187	COG0437	4 iron, 4 sulfur cluster binding
Sgly_2190	COG0281	malic enzyme
Sgly_2192	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Sgly_2195	COG0328	RNA-DNA hybrid ribonuclease activity
Sgly_2196	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Sgly_2198	COG0704	Plays a role in the regulation of phosphate uptake
Sgly_2201	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Sgly_2203	COG0436	Aminotransferase
Sgly_2206	COG2359	stage V sporulation protein S
Sgly_2207	COG1692	metallophosphoesterase
Sgly_2209	COG1418	mRNA catabolic process
Sgly_2211	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Sgly_2212	COG1546	Belongs to the CinA family
Sgly_2212	COG1058	Belongs to the CinA family
Sgly_2213	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Sgly_2214	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Sgly_2215	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Sgly_2216	COG1426	Protein conserved in bacteria
Sgly_2217	COG1674	ftsk spoiiie
Sgly_2218	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Sgly_2219	COG0166	Belongs to the GPI family
Sgly_2227	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sgly_2229	COG2207	Transcriptional regulator
Sgly_2229	COG4753	response regulator
Sgly_2231	COG4251	negative regulation of phosphorylation
Sgly_2232	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Sgly_2233	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Sgly_2234	COG0527	aspartate kinase activity
Sgly_2235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Sgly_2236	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Sgly_2237	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Sgly_2239	COG1873	PFAM PRC-barrel domain
Sgly_2242	COG0612	Peptidase, M16
Sgly_2243	COG1686	Belongs to the peptidase S11 family
Sgly_2244	COG0726	polysaccharide deacetylase
Sgly_2246	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Sgly_2247	COG0196	riboflavin kinase activity
Sgly_2249	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Sgly_2251	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Sgly_2251	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Sgly_2253	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Sgly_2254	COG0195	Participates in both transcription termination and antitermination
Sgly_2255	COG0779	Required for maturation of 30S ribosomal subunits
Sgly_2258	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Sgly_2259	COG0750	zinc metalloprotease
Sgly_2262	COG4589	Belongs to the CDS family
Sgly_2263	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Sgly_2265	COG0233	cytoplasmic translational termination
Sgly_2266	COG0528	UMP kinase activity
Sgly_2273	COG4974	Belongs to the 'phage' integrase family
Sgly_2274	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Sgly_2275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Sgly_2276	COG0758	DNA mediated transformation
Sgly_2278	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Sgly_2279	COG0791	NLP P60 protein
Sgly_2279	COG1388	LysM domain
Sgly_2281	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Sgly_2283	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Sgly_2284	COG1045	serine acetyltransferase
Sgly_2286	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Sgly_2289	COG2720	vancomycin resistance protein
Sgly_2290	COG1742	UPF0060 membrane protein
Sgly_2294	COG0606	chelatase, subunit chli
Sgly_2295	COG0840	transmembrane signaling receptor activity
Sgly_2299	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Sgly_2301	COG4752	Belongs to the RNA methyltransferase TrmD family
Sgly_2302	COG0336	Belongs to the RNA methyltransferase TrmD family
Sgly_2303	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Sgly_2304	COG1837	Belongs to the UPF0109 family
Sgly_2306	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Sgly_2308	COG0402	S-adenosylhomocysteine deaminase activity
Sgly_2310	COG0552	protein localization to endoplasmic reticulum
Sgly_2311	COG1196	nuclear chromosome segregation
Sgly_2312	COG0571	ribonuclease III activity
Sgly_2315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Sgly_2318	COG3314	Sporulation integral membrane protein YlbJ
Sgly_2320	COG0742	ribosomal rna small subunit methyltransferase
Sgly_2321	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Sgly_2324	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Sgly_2325	COG1760	l-serine dehydratase
Sgly_2326	COG1760	l-serine dehydratase
Sgly_2327	COG1461	Dihydroxyacetone kinase
Sgly_2328	COG1302	Protein conserved in bacteria
Sgly_2331	COG1564	THIamine pyrophosphokinase
Sgly_2332	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Sgly_2333	COG1162	GTPase activity
Sgly_2334	COG2815	serine threonine protein kinase
Sgly_2334	COG0515	serine threonine protein kinase
Sgly_2335	COG0768	penicillin binding
Sgly_2337	COG0631	protein serine/threonine phosphatase activity
Sgly_2340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Sgly_2341	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Sgly_2343	COG0242	peptide deformylase activity
Sgly_2344	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Sgly_2347	COG0789	Transcriptional regulator
Sgly_2353	COG0640	Transcriptional regulator
Sgly_2355	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Sgly_2357	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Sgly_2358	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Sgly_2359	COG0047	phosphoribosylformylglycinamidine synthase activity
Sgly_2360	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Sgly_2361	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Sgly_2362	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Sgly_2363	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Sgly_2367	COG0251	oxidation-reduction process
Sgly_2368	COG1606	tRNA processing
Sgly_2370	COG0077	Prephenate dehydratase
Sgly_2370	COG1605	Chorismate mutase
Sgly_2371	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Sgly_2372	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Sgly_2373	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Sgly_2375	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Sgly_2376	COG1322	Protein conserved in bacteria
Sgly_2377	COG3773	Cell wall hydrolase
Sgly_2377	COG3409	Peptidoglycan-binding domain 1 protein
Sgly_2378	COG2959	enzyme of heme biosynthesis
Sgly_2385	COG0351	phosphomethylpyrimidine kinase
Sgly_2387	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Sgly_2388	COG0352	thiamine-phosphate diphosphorylase activity
Sgly_2390	COG1882	Formate acetyltransferase
Sgly_2391	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Sgly_2394	COG0697	spore germination
Sgly_2396	COG0436	Aminotransferase
Sgly_2398	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Sgly_2399	COG2384	SAM-dependent methyltransferase
Sgly_2401	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Sgly_2402	COG0358	DNA primase activity
Sgly_2403	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Sgly_2404	COG2076	Multidrug Resistance protein
Sgly_2405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Sgly_2406	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
Sgly_2412	COG3041	Addiction module toxin RelE StbE family
Sgly_2414	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Sgly_2414	COG0574	Belongs to the PEP-utilizing enzyme family
Sgly_2416	COG0517	IMP dehydrogenase activity
Sgly_2419	COG1381	Involved in DNA repair and RecF pathway recombination
Sgly_2421	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Sgly_2423	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Sgly_2425	COG1480	7TM receptor with intracellular HD hydrolase
Sgly_2426	COG1702	phosphate starvation-inducible protein PhoH
Sgly_2431	COG0537	adenosine 5'-monophosphoramidase activity
Sgly_2433	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Sgly_2434	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Sgly_2435	COG2264	protein methyltransferase activity
Sgly_2438	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Sgly_2440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Sgly_2442	COG0728	peptidoglycan biosynthetic process
Sgly_2448	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Sgly_2450	COG1555	photosystem II stabilization
Sgly_2450	COG1596	polysaccharide export
Sgly_2453	COG0799	negative regulation of ribosome biogenesis
Sgly_2455	COG0724	RNA recognition motif
Sgly_2456	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Sgly_2457	COG1534	Rna-binding protein
Sgly_2461	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Sgly_2465	COG4942	peptidase
Sgly_2466	COG0772	Belongs to the SEDS family
Sgly_2468	COG2894	cell division
Sgly_2471	COG1792	Involved in formation and maintenance of cell shape
Sgly_2472	COG1077	Cell shape determining protein MreB Mrl
Sgly_2473	COG2003	Belongs to the UPF0758 family
Sgly_2474	COG0424	maF-like protein
Sgly_2475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Sgly_2478	COG2247	cell wall binding repeat
Sgly_2478	COG0860	N-Acetylmuramoyl-L-alanine amidase
Sgly_2479	COG0285	dihydrofolate synthase activity
Sgly_2480	COG0525	valine-tRNA ligase activity
Sgly_2481	COG2076	Multidrug Resistance protein
Sgly_2482	COG1216	Glycosyl transferase, family 2
Sgly_2487	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Sgly_2488	COG0470	DNA polymerase III
Sgly_2488	COG1067	ATP-dependent peptidase activity
Sgly_2491	COG0544	peptidyl-prolyl cis-trans isomerase activity
Sgly_2492	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Sgly_2493	COG1272	protein, Hemolysin III
Sgly_2495	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Sgly_2500	COG2894	cell division
Sgly_2505	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Sgly_2508	COG1342	Belongs to the UPF0251 family
Sgly_2509	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Sgly_2511	COG0252	asparaginase activity
Sgly_2512	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sgly_2513	COG2188	Transcriptional regulator
Sgly_2517	COG0277	FAD linked oxidase domain protein
Sgly_2519	COG0247	lactate metabolic process
Sgly_2521	COG3958	Transketolase
Sgly_2522	COG3959	Transketolase, thiamine diphosphate binding domain
Sgly_2524	COG1414	Transcriptional regulator
Sgly_2527	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Sgly_2530	COG2221	Nitrite and sulphite reductase 4Fe-4S
Sgly_2531	COG1609	Transcriptional regulator
Sgly_2533	COG1882	Formate acetyltransferase
Sgly_2537	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Sgly_2538	COG5012	cobalamin binding
Sgly_2539	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Sgly_2542	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Sgly_2545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sgly_2549	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Sgly_2553	COG0823	Involved in the tonB-independent uptake of proteins
Sgly_2553	COG1506	peptidase
Sgly_2553	COG4946	Tricorn protease homolog
Sgly_2554	COG4608	Belongs to the ABC transporter superfamily
Sgly_2555	COG0444	Belongs to the ABC transporter superfamily
Sgly_2557	COG1028	Short-chain dehydrogenase reductase Sdr
Sgly_2560	COG0747	negative chemotaxis
Sgly_2568	COG3620	sequence-specific DNA binding
Sgly_2570	COG0464	growth
Sgly_2571	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Sgly_2572	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Sgly_2575	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Sgly_2575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Sgly_2577	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Sgly_2578	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Sgly_2579	COG1846	Transcriptional regulator
Sgly_2580	COG5401	PFAM Sporulation and spore germination
Sgly_2582	COG0428	transporter
Sgly_2587	COG3409	Peptidoglycan-binding domain 1 protein
Sgly_2587	COG3773	Cell wall hydrolase
Sgly_2588	COG0793	Belongs to the peptidase S41A family
Sgly_2588	COG3409	Peptidoglycan-binding domain 1 protein
Sgly_2617	COG4397	Mu-like prophage major head subunit gpT
Sgly_2620	COG2369	cell adhesion
Sgly_2621	COG4383	Mu-like prophage protein gp29
Sgly_2646	COG0463	Glycosyl transferase, family 2
Sgly_2649	COG1360	Flagellar Motor Protein
Sgly_2650	COG4935	Belongs to the peptidase S8 family
Sgly_2650	COG2234	aminopeptidase activity
Sgly_2651	COG1728	Protein conserved in bacteria
Sgly_2652	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Sgly_2654	COG1131	(ABC) transporter
Sgly_2658	COG3620	sequence-specific DNA binding
Sgly_2662	COG0582	viral genome integration into host DNA
Sgly_2663	COG1476	TRANSCRIPTIONal
Sgly_2664	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
Sgly_2669	COG0519	Catalyzes the synthesis of GMP from XMP
Sgly_2669	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Sgly_2672	COG0488	(ABC) transporter
Sgly_2676	COG0459	protein refolding
Sgly_2679	COG0347	Belongs to the P(II) protein family
Sgly_2683	COG1846	Transcriptional regulator
Sgly_2685	COG3383	formate dehydrogenase (NAD+) activity
Sgly_2688	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Sgly_2689	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Sgly_2690	COG0456	acetyltransferase
Sgly_2691	COG1214	PFAM Peptidase M22, glycoprotease
Sgly_2692	COG0802	atpase or kinase
Sgly_2693	COG1228	amidohydrolase
Sgly_2694	COG2337	Toxic component of a toxin-antitoxin (TA) module
Sgly_2698	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Sgly_2701	COG0493	'glutamate synthase
Sgly_2702	COG0070	glutamate synthase
Sgly_2702	COG0069	glutamate synthase activity
Sgly_2702	COG0067	glutamate synthase
Sgly_2703	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Sgly_2704	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Sgly_2704	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Sgly_2705	COG0736	holo-[acyl-carrier-protein] synthase activity
Sgly_2708	COG1242	4 iron, 4 sulfur cluster binding
Sgly_2709	COG3300	MHYT domain
Sgly_2709	COG5001	Diguanylate cyclase
Sgly_2710	COG0004	ammonium transporteR
Sgly_2711	COG3885	ferrous iron binding
Sgly_2711	COG2078	PFAM AMMECR1 domain protein
Sgly_2714	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
Sgly_2716	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Sgly_2717	COG1027	Aspartate ammonia-lyase
Sgly_2718	COG1160	GTP binding
Sgly_2728	COG1012	belongs to the aldehyde dehydrogenase family
Sgly_2728	COG1454	alcohol dehydrogenase
Sgly_2732	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Sgly_2735	COG2814	Major facilitator Superfamily
Sgly_2744	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sgly_2758	COG1132	(ABC) transporter
Sgly_2760	COG1309	transcriptional regulator
Sgly_2761	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Sgly_2762	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sgly_2763	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sgly_2765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sgly_2768	COG0778	Nitroreductase
Sgly_2769	COG0535	radical SAM domain protein
Sgly_2769	COG1433	Dinitrogenase iron-molybdenum cofactor
Sgly_2772	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sgly_2773	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sgly_2774	COG2197	response regulator
Sgly_2775	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sgly_2777	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sgly_2782	COG2217	Heavy metal translocating P-type atpase
Sgly_2784	COG0626	cystathionine gamma-synthase activity
Sgly_2785	COG0626	cystathionine gamma-synthase activity
Sgly_2788	COG5012	cobalamin binding
Sgly_2790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Sgly_2792	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sgly_2795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Sgly_2796	COG2385	sporulation resulting in formation of a cellular spore
Sgly_2796	COG2247	cell wall binding repeat
Sgly_2798	COG1132	(ABC) transporter
Sgly_2799	COG1132	(ABC) transporter
Sgly_2802	COG0840	transmembrane signaling receptor activity
Sgly_2804	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Sgly_2805	COG5583	Uncharacterized small protein (DUF2292)
Sgly_2807	COG1464	Belongs to the NlpA lipoprotein family
Sgly_2808	COG2011	ABC-type metal ion transport system permease component
Sgly_2809	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Sgly_2810	COG0535	radical SAM domain protein
Sgly_2810	COG1433	Dinitrogenase iron-molybdenum cofactor
Sgly_2811	COG0626	cystathionine gamma-synthase activity
Sgly_2812	COG0840	transmembrane signaling receptor activity
Sgly_2813	COG0646	methionine synthase
Sgly_2813	COG1410	methionine synthase
Sgly_2814	COG1151	hydroxylamine reductase activity
Sgly_2815	COG0011	TIGRFAM Protein of
Sgly_2816	COG0326	Molecular chaperone. Has ATPase activity
Sgly_2818	COG0586	Pfam SNARE associated Golgi protein
Sgly_2820	COG4942	peptidase
Sgly_2823	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sgly_2828	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sgly_2831	COG1959	2 iron, 2 sulfur cluster binding
Sgly_2832	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Sgly_2837	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
Sgly_2839	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sgly_2840	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sgly_2841	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Sgly_2842	COG0347	Belongs to the P(II) protein family
Sgly_2843	COG0347	Belongs to the P(II) protein family
Sgly_2851	COG0347	Belongs to the P(II) protein family
Sgly_2854	COG1910	domain protein
Sgly_2856	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Sgly_2857	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Sgly_2858	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Sgly_2861	COG0583	DNA-binding transcription factor activity
Sgly_2864	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Sgly_2864	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Sgly_2869	COG0159	tryptophan synthase activity
Sgly_2874	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Sgly_2874	COG0512	Glutamine amidotransferase of anthranilate synthase
Sgly_2882	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Sgly_2883	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Sgly_2884	COG1797	cobyrinic acid a,c-diamide synthase activity
Sgly_2887	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Sgly_2888	COG0113	porphobilinogen synthase activity
Sgly_2892	COG2875	Belongs to the precorrin methyltransferase family
Sgly_2895	COG1122	ATPase activity
Sgly_2898	COG0310	cobalt ion transport
Sgly_2899	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Sgly_2901	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Sgly_2903	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Sgly_2905	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Sgly_2906	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Sgly_2909	COG1132	(ABC) transporter
Sgly_2917	COG0514	ATP-dependent DNA helicase (RecQ)
Sgly_2918	COG1132	(ABC) transporter
Sgly_2919	COG1994	Peptidase M50
Sgly_2920	COG0494	nUDIX hydrolase
Sgly_2923	COG0745	RESPONSE REGULATOR receiver
Sgly_2924	COG5002	protein histidine kinase activity
Sgly_2926	COG1131	(ABC) transporter
Sgly_2928	COG2814	Major facilitator Superfamily
Sgly_2929	COG0519	Catalyzes the synthesis of GMP from XMP
Sgly_2929	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Sgly_2932	COG1733	regulation of RNA biosynthetic process
Sgly_2933	COG0655	NAD(P)H dehydrogenase (quinone) activity
Sgly_2934	COG0688	phosphatidylethanolamine metabolic process
Sgly_2935	COG3300	MHYT domain
Sgly_2935	COG5001	Diguanylate cyclase
Sgly_2936	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Sgly_2937	COG0577	efflux transmembrane transporter activity
Sgly_2937	COG1136	(ABC) transporter
Sgly_2964	COG4397	Mu-like prophage major head subunit gpT
Sgly_2967	COG2369	cell adhesion
Sgly_2968	COG4383	Mu-like prophage protein gp29
Sgly_2992	COG1309	transcriptional regulator
Sgly_2993	COG0860	N-Acetylmuramoyl-L-alanine amidase
Sgly_2993	COG2247	cell wall binding repeat
Sgly_2997	COG1404	Belongs to the peptidase S8 family
Sgly_2998	COG2247	cell wall binding repeat
Sgly_2998	COG0860	N-Acetylmuramoyl-L-alanine amidase
Sgly_3000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Sgly_3004	COG0438	transferase activity, transferring glycosyl groups
Sgly_3011	COG1086	Polysaccharide biosynthesis protein
Sgly_3012	COG2247	cell wall binding repeat
Sgly_3012	COG0860	N-Acetylmuramoyl-L-alanine amidase
Sgly_3013	COG2385	sporulation resulting in formation of a cellular spore
Sgly_3013	COG2247	cell wall binding repeat
Sgly_3016	COG0640	Transcriptional regulator
Sgly_3021	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Sgly_3022	COG0740	serine-type endopeptidase activity
Sgly_3024	COG1620	l-lactate permease
Sgly_3025	COG1620	l-lactate permease
Sgly_3027	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Sgly_3027	COG0825	malonyl-CoA metabolic process
Sgly_3028	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Sgly_3029	COG0439	Biotin carboxylase
Sgly_3030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Sgly_3031	COG0511	ligase activity, forming carbon-carbon bonds
Sgly_3032	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Sgly_3033	COG1028	Short-chain dehydrogenase reductase Sdr
Sgly_3034	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Sgly_3035	COG2070	2-Nitropropane dioxygenase
Sgly_3036	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Sgly_3037	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Sgly_3039	COG0531	amino acid
Sgly_3043	COG1592	Rubrerythrin
Sgly_3044	COG2033	superoxide reductase activity
Sgly_3045	COG0426	domain, Protein
Sgly_3046	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Sgly_3046	COG1773	rubredoxin
Sgly_3049	COG0513	Belongs to the DEAD box helicase family
Sgly_3050	COG0583	DNA-binding transcription factor activity
Sgly_3051	COG2807	transmembrane transport
Sgly_3052	COG0589	response to stress
Sgly_3058	COG1846	Transcriptional regulator
Sgly_3061	COG1346	cytolysis
Sgly_3062	COG1380	Effector of murein hydrolase LrgA
Sgly_3064	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Sgly_3068	COG4632	Exopolysaccharide biosynthesis protein
Sgly_3068	COG5434	Belongs to the glycosyl hydrolase 28 family
Sgly_3070	COG3973	AAA domain
Sgly_3071	COG3942	CHAP domain
Sgly_3071	COG1388	LysM domain
Sgly_3072	COG2827	Endonuclease containing a URI domain
Sgly_3073	COG0745	RESPONSE REGULATOR receiver
Sgly_3073	COG3706	GGDEF domain
Sgly_3076	COG0521	Mo-molybdopterin cofactor biosynthetic process
Sgly_3077	COG0315	cyclic pyranopterin monophosphate synthase activity
Sgly_3078	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Sgly_3079	COG0303	'Molybdopterin
Sgly_3085	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Sgly_3086	COG1122	ATPase activity
Sgly_3087	COG1122	ATPase activity
Sgly_3089	COG1929	Belongs to the glycerate kinase type-1 family
Sgly_3090	COG2084	Dehydrogenase
Sgly_3091	COG3622	Belongs to the hyi family
Sgly_3092	COG3960	tartronate-semialdehyde synthase activity
Sgly_3093	COG0588	phosphoglycerate mutase activity
Sgly_3099	COG1120	ATPase activity
Sgly_3100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sgly_3101	COG1720	tRNA m6t6A37 methyltransferase activity
Sgly_3103	COG0444	Belongs to the ABC transporter superfamily
Sgly_3105	COG4129	membrane
Sgly_3106	COG0586	Pfam SNARE associated Golgi protein
Sgly_3107	COG1283	sodium-dependent phosphate transmembrane transporter activity
Sgly_3108	COG0602	queuosine metabolic process
Sgly_3109	COG0720	synthase
Sgly_3110	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Sgly_3111	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Sgly_3139	COG4397	Mu-like prophage major head subunit gpT
Sgly_3142	COG2369	cell adhesion
Sgly_3143	COG4383	Mu-like prophage protein gp29
Sgly_3163	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Sgly_3163	COG2199	diguanylate cyclase activity
Sgly_3164	COG3852	Histidine kinase
Sgly_3165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Sgly_3169	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Sgly_3170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Sgly_3172	COG5002	protein histidine kinase activity
Sgly_3173	COG0745	RESPONSE REGULATOR receiver
Sgly_3176	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Sgly_3177	COG1982	Orn Lys Arg decarboxylase major
Sgly_3184	COG0582	viral genome integration into host DNA
Sgly_3185	COG1194	a g-specific adenine glycosylase
Sgly_3186	COG3585	molybdate ion transport
Sgly_3187	COG2267	carboxylic ester hydrolase activity
Sgly_3192	COG2378	regulation of single-species biofilm formation
Sgly_3196	COG0586	Pfam SNARE associated Golgi protein
Sgly_3197	COG0589	response to stress
Sgly_3198	COG0861	Integral membrane protein TerC family
Sgly_3208	COG2226	methyltransferase
Sgly_3209	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Sgly_3210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Sgly_3211	COG0148	phosphopyruvate hydratase activity
Sgly_3213	COG0149	triose-phosphate isomerase activity
Sgly_3214	COG0126	phosphoglycerate kinase activity
Sgly_3215	COG1283	sodium-dependent phosphate transmembrane transporter activity
Sgly_3217	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Sgly_3221	COG0561	phosphatase activity
Sgly_3224	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Sgly_3225	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Sgly_3235	COG2949	membrane
Sgly_3236	COG0024	Methionine aminopeptidase
Sgly_3240	COG1329	Transcriptional regulator
Sgly_3242	COG1162	GTPase activity
Sgly_3243	COG0288	reversible hydration of carbon dioxide
Sgly_3244	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Sgly_3245	COG0556	nucleotide-excision repair
Sgly_3247	COG0793	Belongs to the peptidase S41A family
Sgly_3247	COG3409	Peptidoglycan-binding domain 1 protein
Sgly_3248	COG0739	heme binding
Sgly_3248	COG1196	nuclear chromosome segregation
Sgly_3248	COG0741	lytic transglycosylase activity
Sgly_3249	COG2177	Part of the ABC transporter FtsEX involved in
Sgly_3250	COG2884	Cell division ATP-binding protein ftsE
Sgly_3251	COG3958	Transketolase
Sgly_3252	COG3959	Transketolase, thiamine diphosphate binding domain
Sgly_3257	COG0653	protein targeting
Sgly_3258	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Sgly_3260	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
Sgly_3263	COG0438	transferase activity, transferring glycosyl groups
Sgly_3265	COG1077	Cell shape determining protein MreB Mrl
Sgly_3266	COG1609	Transcriptional regulator
Sgly_3267	COG2385	sporulation resulting in formation of a cellular spore
Sgly_3268	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Sgly_3275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Sgly_3276	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Sgly_3277	COG0356	it plays a direct role in the translocation of protons across the membrane
Sgly_3280	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Sgly_3283	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Sgly_3284	COG0698	ribose 5-phosphate isomerase
Sgly_3286	COG1971	Probably functions as a manganese efflux pump
Sgly_3287	COG0009	L-threonylcarbamoyladenylate synthase
Sgly_3288	COG2890	protein-(glutamine-N5) methyltransferase activity
Sgly_3289	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Sgly_3290	COG3872	metal-dependent enzyme
Sgly_3292	COG1494	fructose-1,6-bisphosphatase
Sgly_3296	COG2204	response regulator
Sgly_3297	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Sgly_3298	COG2348	transferase activity, transferring amino-acyl groups
Sgly_3299	COG0504	CTP synthase activity
Sgly_3301	COG2959	enzyme of heme biosynthesis
Sgly_3302	COG3773	Cell wall hydrolase
Sgly_3302	COG3409	Peptidoglycan-binding domain 1 protein
Sgly_3303	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Sgly_3305	COG0116	Belongs to the methyltransferase superfamily
Sgly_3307	COG3706	GGDEF domain
Sgly_3309	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Sgly_3310	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Sgly_3312	COG2119	membrane
Sgly_3314	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Sgly_3315	COG2188	Transcriptional regulator
Sgly_3316	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Sgly_3317	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Sgly_3320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Sgly_3321	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Sgly_3322	COG3383	formate dehydrogenase (NAD+) activity
Sgly_3326	COG1122	ATPase activity
Sgly_3331	COG1131	(ABC) transporter
Sgly_3333	COG2197	response regulator
Sgly_3334	COG4585	Histidine kinase
Sgly_3335	COG1216	Glycosyl transferase, family 2
Sgly_3335	COG1442	glycosyl transferase family 8
Sgly_3339	COG1131	(ABC) transporter
Sgly_3342	COG0772	Belongs to the SEDS family
Sgly_3343	COG1695	Transcriptional regulator
Sgly_3344	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Sgly_3345	COG0305	Participates in initiation and elongation during chromosome replication
Sgly_3346	COG0470	DNA polymerase III
Sgly_3346	COG1067	ATP-dependent peptidase activity
Sgly_3350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Sgly_3351	COG0629	single-stranded DNA binding
Sgly_3353	COG0012	GTP binding
Sgly_3356	COG0683	leucine binding
Sgly_3358	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Sgly_3361	COG1475	DNA binding
Sgly_3362	COG1192	Involved in chromosome partitioning
Sgly_3363	COG0357	Ribosomal RNA small subunit methyltransferase G
Sgly_3364	COG0445	tRNA wobble uridine modification
Sgly_3365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Sgly_3366	COG1847	R3H domain protein
Sgly_3367	COG0706	membrane insertase activity
Sgly_3368	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Sgly_3370	COG0230	Belongs to the bacterial ribosomal protein bL34 family