locus-tag	class	description
Swol_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Swol_0002	COG0592	DNA-directed DNA polymerase activity
Swol_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Swol_0005	COG0187	DNA topoisomerase II activity
Swol_0006	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Swol_0007	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Swol_0009	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Swol_0010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Swol_0014	COG1322	Protein conserved in bacteria
Swol_0026	COG1309	transcriptional regulator
Swol_0028	COG0116	Belongs to the methyltransferase superfamily
Swol_0030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Swol_0031	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Swol_0032	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Swol_0039	COG1982	Orn Lys Arg decarboxylase major
Swol_0040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Swol_0042	COG0470	DNA polymerase III
Swol_0043	COG1774	PSP1 C-terminal conserved region
Swol_0044	COG4467	Involved in initiation control of chromosome replication
Swol_0045	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Swol_0046	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Swol_0047	COG2002	toxin-antitoxin pair type II binding
Swol_0049	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Swol_0049	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Swol_0050	COG0084	hydrolase, TatD family'
Swol_0051	COG3583	domain protein
Swol_0051	COG3584	3D domain protein
Swol_0053	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Swol_0054	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Swol_0055	COG4466	Protein conserved in bacteria
Swol_0058	COG0438	transferase activity, transferring glycosyl groups
Swol_0062	COG1752	Esterase of the alpha-beta hydrolase superfamily
Swol_0064	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Swol_0065	COG1802	Transcriptional regulator
Swol_0067	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Swol_0068	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Swol_0069	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Swol_0070	COG0193	aminoacyl-tRNA hydrolase activity
Swol_0073	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Swol_0078	COG0697	spore germination
Swol_0080	COG2002	toxin-antitoxin pair type II binding
Swol_0081	COG2244	polysaccharide biosynthetic process
Swol_0082	COG3956	TIGRFAM MazG family protein
Swol_0084	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Swol_0089	COG1098	S1 RNA binding domain
Swol_0090	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Swol_0090	COG0248	Ppx GppA phosphatase
Swol_0091	COG2116	formate transmembrane transporter activity
Swol_0094	COG0037	tRNA processing
Swol_0096	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Swol_0097	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Swol_0098	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Swol_0101	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Swol_0102	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Swol_0103	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Swol_0104	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Swol_0105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Swol_0109	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Swol_0110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Swol_0115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Swol_0116	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Swol_0117	COG1696	Membrane protein involved in D-alanine export
Swol_0122	COG0728	peptidoglycan biosynthetic process
Swol_0124	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Swol_0125	COG1316	TRANSCRIPTIONal
Swol_0126	COG4991	sh3 domain protein
Swol_0126	COG0860	N-Acetylmuramoyl-L-alanine amidase
Swol_0126	COG3103	Sh3 type 3 domain protein
Swol_0126	COG4991	sh3 domain protein
Swol_0126	COG0860	N-Acetylmuramoyl-L-alanine amidase
Swol_0126	COG3103	Sh3 type 3 domain protein
Swol_0128	COG1086	Polysaccharide biosynthesis protein
Swol_0136	COG1943	Transposase
Swol_0147	COG5464	transposase or invertase
Swol_0148	COG1943	Transposase
Swol_0149	COG4626	Terminase
Swol_0149	COG1802	Transcriptional regulator
Swol_0155	COG3328	transposase activity
Swol_0162	COG1404	Belongs to the peptidase S8 family
Swol_0168	COG0793	Belongs to the peptidase S41A family
Swol_0180	COG1131	(ABC) transporter
Swol_0182	COG0842	Transport permease protein
Swol_0184	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Swol_0186	COG2197	response regulator
Swol_0188	COG1040	competence protein
Swol_0193	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Swol_0195	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Swol_0196	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Swol_0197	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Swol_0197	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Swol_0201	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
Swol_0203	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Swol_0210	COG2089	acid synthase
Swol_0211	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Swol_0212	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Swol_0221	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
Swol_0223	COG1192	Involved in chromosome partitioning
Swol_0227	COG1086	Polysaccharide biosynthesis protein
Swol_0229	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Swol_0237	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Swol_0238	COG0653	protein targeting
Swol_0239	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Swol_0241	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Swol_0243	COG3959	Transketolase, thiamine diphosphate binding domain
Swol_0244	COG3958	Transketolase
Swol_0245	COG2884	Cell division ATP-binding protein ftsE
Swol_0246	COG2177	Part of the ABC transporter FtsEX involved in
Swol_0247	COG0739	heme binding
Swol_0247	COG0741	lytic transglycosylase activity
Swol_0247	COG1196	nuclear chromosome segregation
Swol_0248	COG0793	Belongs to the peptidase S41A family
Swol_0249	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Swol_0251	COG0556	nucleotide-excision repair
Swol_0252	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Swol_0254	COG0322	excinuclease ABC activity
Swol_0255	COG1950	PFAM Membrane protein of
Swol_0258	COG0561	phosphatase activity
Swol_0260	COG2222	sugar isomerase
Swol_0262	COG1660	Displays ATPase and GTPase activities
Swol_0263	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Swol_0264	COG1481	regulation of sporulation
Swol_0265	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Swol_0266	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Swol_0267	COG2086	electron transfer activity
Swol_0268	COG1960	acyl-CoA dehydrogenase activity
Swol_0269	COG1846	Transcriptional regulator
Swol_0273	COG0126	phosphoglycerate kinase activity
Swol_0274	COG0149	triose-phosphate isomerase activity
Swol_0275	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Swol_0276	COG0148	phosphopyruvate hydratase activity
Swol_0277	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Swol_0280	COG0557	exoribonuclease II activity
Swol_0281	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Swol_0294	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Swol_0305	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Swol_0306	COG3829	transcription factor binding
Swol_0306	COG3290	protein histidine kinase activity
Swol_0307	COG1250	3-hydroxyacyl-CoA dehydrogenase
Swol_0308	COG0183	Belongs to the thiolase family
Swol_0309	COG0427	acetyl-CoA hydrolase
Swol_0311	COG1301	dicarboxylic acid transport
Swol_0313	COG0534	Mate efflux family protein
Swol_0314	COG1126	abc transporter atp-binding protein
Swol_0315	COG0765	amino acid transport
Swol_0316	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Swol_0318	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Swol_0321	COG2323	membrane
Swol_0323	COG1122	ATPase activity
Swol_0324	COG4120	Belongs to the binding-protein-dependent transport system permease family
Swol_0333	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Swol_0334	COG0745	RESPONSE REGULATOR receiver
Swol_0339	COG1116	anion transmembrane transporter activity
Swol_0340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Swol_0342	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Swol_0344	COG0850	regulation of cytokinetic process
Swol_0345	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Swol_0346	COG2894	cell division
Swol_0347	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Swol_0348	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Swol_0348	COG2199	diguanylate cyclase activity
Swol_0352	COG0659	secondary active sulfate transmembrane transporter activity
Swol_0353	COG0643	Histidine kinase
Swol_0353	COG2198	Histidine kinase
Swol_0355	COG2201	protein-glutamate methylesterase activity
Swol_0356	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Swol_0358	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Swol_0359	COG0134	indole-3-glycerol-phosphate synthase activity
Swol_0360	COG0135	phosphoribosylanthranilate isomerase activity
Swol_0361	COG0133	tryptophan synthase activity
Swol_0362	COG0159	tryptophan synthase activity
Swol_0363	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Swol_0364	COG0512	Glutamine amidotransferase of anthranilate synthase
Swol_0364	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Swol_0365	COG0840	transmembrane signaling receptor activity
Swol_0369	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Swol_0371	COG1811	Na channel or pump
Swol_0372	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Swol_0373	COG0154	amidase activity
Swol_0374	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Swol_0375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Swol_0377	COG0066	3-isopropylmalate dehydratase activity
Swol_0378	COG0538	isocitrate dehydrogenase activity
Swol_0380	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Swol_0381	COG0784	Response regulator, receiver
Swol_0381	COG5002	protein histidine kinase activity
Swol_0384	COG1960	acyl-CoA dehydrogenase activity
Swol_0386	COG1077	Cell shape determining protein MreB Mrl
Swol_0392	COG4115	mRNA cleavage
Swol_0402	COG2871	sodium ion transport
Swol_0403	COG0395	ABC-type sugar transport system, permease component
Swol_0404	COG1175	transmembrane transport
Swol_0408	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Swol_0409	COG3842	ATPase activity
Swol_0410	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Swol_0414	COG1129	ABC transporter
Swol_0417	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Swol_0418	COG5012	cobalamin binding
Swol_0423	COG1879	ABC-type sugar transport system periplasmic component
Swol_0425	COG1172	Belongs to the binding-protein-dependent transport system permease family
Swol_0426	COG1129	ABC transporter
Swol_0427	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Swol_0428	COG1924	4 iron, 4 sulfur cluster binding
Swol_0430	COG2801	Transposase and inactivated derivatives
Swol_0435	COG1250	3-hydroxyacyl-CoA dehydrogenase
Swol_0436	COG0427	acetyl-CoA hydrolase
Swol_0437	COG3829	transcription factor binding
Swol_0437	COG3290	protein histidine kinase activity
Swol_0438	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Swol_0442	COG1307	EDD domain protein, DegV family
Swol_0443	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Swol_0444	COG3279	Response regulator of the LytR AlgR family
Swol_0446	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Swol_0446	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Swol_0452	COG1924	4 iron, 4 sulfur cluster binding
Swol_0453	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Swol_0454	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Swol_0456	COG3829	transcription factor binding
Swol_0456	COG3290	protein histidine kinase activity
Swol_0461	COG1937	Protein conserved in bacteria
Swol_0462	COG3118	belongs to the thioredoxin family
Swol_0464	COG0482	sulfurtransferase activity
Swol_0467	COG0628	permease
Swol_0468	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Swol_0469	COG4472	Bacterial protein of unknown function (DUF965)
Swol_0470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Swol_0471	COG3906	Belongs to the UPF0473 family
Swol_0472	COG2720	vancomycin resistance protein
Swol_0473	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Swol_0480	COG1518	maintenance of DNA repeat elements
Swol_0483	COG3093	addiction module antidote protein HigA
Swol_0488	COG1960	acyl-CoA dehydrogenase activity
Swol_0489	COG0768	penicillin binding
Swol_0490	COG0443	Heat shock 70 kDa protein
Swol_0493	COG0542	response to heat
Swol_0501	COG1191	sigma factor activity
Swol_0506	COG3547	Transposase (IS116 IS110 IS902 family)
Swol_0507	COG0210	DNA helicase
Swol_0511	COG0513	Belongs to the DEAD box helicase family
Swol_0516	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
Swol_0517	COG1191	sigma factor activity
Swol_0519	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Swol_0523	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Swol_0524	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Swol_0526	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
Swol_0527	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Swol_0528	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Swol_0529	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Swol_0531	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Swol_0533	COG1459	type II secretion system
Swol_0534	COG4968	Prepilin-type N-terminal cleavage methylation domain
Swol_0538	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Swol_0542	COG0312	modulator of DNA gyrase
Swol_0543	COG0312	modulator of DNA gyrase
Swol_0544	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Swol_0546	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Swol_0550	COG3854	ATPases associated with a variety of cellular activities
Swol_0558	COG5016	pyruvate
Swol_0558	COG0511	ligase activity, forming carbon-carbon bonds
Swol_0559	COG0439	Biotin carboxylase
Swol_0561	COG1302	Protein conserved in bacteria
Swol_0564	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Swol_0565	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Swol_0566	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Swol_0567	COG1570	exodeoxyribonuclease VII activity
Swol_0568	COG1722	exodeoxyribonuclease VII activity
Swol_0575	COG0534	Mate efflux family protein
Swol_0582	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Swol_0583	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Swol_0584	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Swol_0585	COG1438	arginine binding
Swol_0587	COG0497	DNA recombination
Swol_0588	COG0071	Belongs to the small heat shock protein (HSP20) family
Swol_0589	COG0750	zinc metalloprotease
Swol_0590	COG0745	RESPONSE REGULATOR receiver
Swol_0595	COG2195	Cleaves the N-terminal amino acid of tripeptides
Swol_0598	COG1379	DNA repair
Swol_0600	COG0745	RESPONSE REGULATOR receiver
Swol_0600	COG3706	GGDEF domain
Swol_0605	COG1300	Membrane
Swol_0607	COG4974	Belongs to the 'phage' integrase family
Swol_0608	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Swol_0612	COG1686	Belongs to the peptidase S11 family
Swol_0614	COG2172	sigma factor antagonist activity
Swol_0615	COG1191	sigma factor activity
Swol_0618	COG1088	dTDP-glucose 4,6-dehydratase activity
Swol_0619	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Swol_0620	COG1598	PFAM Uncharacterised protein family UPF0150
Swol_0627	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Swol_0629	COG0697	spore germination
Swol_0632	COG1924	4 iron, 4 sulfur cluster binding
Swol_0639	COG0351	phosphomethylpyrimidine kinase
Swol_0640	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Swol_0641	COG0352	thiamine-phosphate diphosphorylase activity
Swol_0642	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
Swol_0643	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Swol_0644	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Swol_0646	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Swol_0648	COG0776	regulation of translation
Swol_0651	COG1028	Short-chain dehydrogenase reductase Sdr
Swol_0653	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Swol_0655	COG3679	Belongs to the UPF0342 family
Swol_0660	COG0735	belongs to the Fur family
Swol_0661	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Swol_0663	COG0489	protein tyrosine kinase activity
Swol_0665	COG0719	Fe-S assembly protein
Swol_0666	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Swol_0666	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Swol_0669	COG0010	Belongs to the arginase family
Swol_0670	COG1592	Rubrerythrin
Swol_0672	COG0180	Tryptophanyl-tRNA synthetase
Swol_0674	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Swol_0675	COG0183	Belongs to the thiolase family
Swol_0677	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Swol_0681	COG0805	protein transport
Swol_0682	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Swol_0683	COG1648	precorrin-2 dehydrogenase activity
Swol_0683	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Swol_0685	COG0181	hydroxymethylbilane synthase activity
Swol_0688	COG0535	radical SAM domain protein
Swol_0690	COG0113	porphobilinogen synthase activity
Swol_0694	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Swol_0695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Swol_0696	COG2086	electron transfer activity
Swol_0697	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Swol_0698	COG0247	lactate metabolic process
Swol_0698	COG2181	nitrate reductase activity
Swol_0699	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Swol_0706	COG0673	inositol 2-dehydrogenase activity
Swol_0708	COG0579	oxidoreductase
Swol_0710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Swol_0711	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Swol_0712	COG0367	asparagine synthase
Swol_0717	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Swol_0731	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Swol_0736	COG4974	Belongs to the 'phage' integrase family
Swol_0738	COG4974	Belongs to the 'phage' integrase family
Swol_0740	COG4974	Belongs to the 'phage' integrase family
Swol_0744	COG1192	Involved in chromosome partitioning
Swol_0756	COG3583	domain protein
Swol_0756	COG3584	3D domain protein
Swol_0757	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Swol_0758	COG1302	Protein conserved in bacteria
Swol_0759	COG1461	Dihydroxyacetone kinase
Swol_0761	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Swol_0764	COG3314	Sporulation integral membrane protein YlbJ
Swol_0765	COG1752	Esterase of the alpha-beta hydrolase superfamily
Swol_0766	COG1323	Belongs to the UPF0348 family
Swol_0767	COG0280	phosphate acetyltransferase
Swol_0768	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Swol_0770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Swol_0771	COG0416	fatty acid biosynthetic process
Swol_0772	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Swol_0773	COG0571	ribonuclease III activity
Swol_0776	COG1196	nuclear chromosome segregation
Swol_0777	COG0552	protein localization to endoplasmic reticulum
Swol_0778	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Swol_0779	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Swol_0781	COG0402	S-adenosylhomocysteine deaminase activity
Swol_0783	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Swol_0786	COG3383	formate dehydrogenase (NAD+) activity
Swol_0787	COG0427	acetyl-CoA hydrolase
Swol_0788	COG1960	acyl-CoA dehydrogenase activity
Swol_0790	COG1024	Enoyl-CoA hydratase
Swol_0791	COG1250	3-hydroxyacyl-CoA dehydrogenase
Swol_0792	COG3290	protein histidine kinase activity
Swol_0792	COG3829	transcription factor binding
Swol_0795	COG1598	PFAM Uncharacterised protein family UPF0150
Swol_0797	COG2864	formate dehydrogenase
Swol_0798	COG0437	4 iron, 4 sulfur cluster binding
Swol_0801	COG0303	'Molybdopterin
Swol_0802	COG0303	'Molybdopterin
Swol_0805	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Swol_0805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Swol_0806	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Swol_0807	COG1490	D-aminoacyl-tRNA deacylase activity
Swol_0808	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Swol_0809	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Swol_0810	COG0077	Prephenate dehydratase
Swol_0811	COG0124	histidyl-tRNA synthetase
Swol_0812	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Swol_0813	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Swol_0814	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Swol_0815	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Swol_0817	COG2001	Belongs to the MraZ family
Swol_0820	COG0768	penicillin binding
Swol_0821	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Swol_0822	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Swol_0823	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Swol_0824	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Swol_0825	COG0772	Belongs to the SEDS family
Swol_0826	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Swol_0827	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Swol_0828	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Swol_0829	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Swol_0831	COG3856	small basic protein
Swol_0833	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Swol_0835	COG1191	sigma factor activity
Swol_0836	COG1191	sigma factor activity
Swol_0839	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Swol_0839	COG0758	DNA mediated transformation
Swol_0840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Swol_0841	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Swol_0842	COG4974	Belongs to the 'phage' integrase family
Swol_0843	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Swol_0844	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Swol_0846	COG1815	bacterial-type flagellum-dependent cell motility
Swol_0848	COG1677	Flagellar hook-basal body complex protein FliE
Swol_0849	COG1766	The M ring may be actively involved in energy transduction
Swol_0852	COG1157	protein secretion by the type III secretion system
Swol_0856	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Swol_0861	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Swol_0862	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Swol_0862	COG1776	CheC inhibitor of MCP methylation
Swol_0863	COG2201	protein-glutamate methylesterase activity
Swol_0865	COG1338	Plays a role in the flagellum-specific transport system
Swol_0866	COG1987	bacterial-type flagellum assembly
Swol_0867	COG1684	flagellar biosynthetic protein fliR
Swol_0868	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Swol_0869	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Swol_0870	COG1419	protein localization to endoplasmic reticulum
Swol_0871	COG0455	bacterial-type flagellum organization
Swol_0873	COG2201	protein-glutamate methylesterase activity
Swol_0874	COG0643	Histidine kinase
Swol_0874	COG2198	Histidine kinase
Swol_0875	COG0835	chemotaxis
Swol_0876	COG1776	CheC inhibitor of MCP methylation
Swol_0877	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Swol_0878	COG1191	sigma factor activity
Swol_0882	COG0052	Belongs to the universal ribosomal protein uS2 family
Swol_0883	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Swol_0884	COG0528	UMP kinase activity
Swol_0885	COG0233	cytoplasmic translational termination
Swol_0886	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Swol_0887	COG4589	Belongs to the CDS family
Swol_0888	COG0628	permease
Swol_0889	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Swol_0890	COG0750	zinc metalloprotease
Swol_0891	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Swol_0892	COG0442	prolyl-tRNA aminoacylation
Swol_0894	COG1285	pathogenesis
Swol_0895	COG2176	DNA-directed DNA polymerase activity
Swol_0896	COG0779	Required for maturation of 30S ribosomal subunits
Swol_0897	COG0195	Participates in both transcription termination and antitermination
Swol_0898	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Swol_0900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Swol_0901	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Swol_0902	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Swol_0903	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Swol_0904	COG0196	riboflavin kinase activity
Swol_0905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Swol_0906	COG1185	polyribonucleotide nucleotidyltransferase activity
Swol_0908	COG0726	polysaccharide deacetylase
Swol_0909	COG1686	Belongs to the peptidase S11 family
Swol_0910	COG0612	Peptidase, M16
Swol_0911	COG0756	dUTP diphosphatase activity
Swol_0913	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Swol_0914	COG0569	domain protein
Swol_0916	COG0517	IMP dehydrogenase activity
Swol_0916	COG0516	GMP reductase activity
Swol_0917	COG1285	pathogenesis
Swol_0921	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Swol_0922	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Swol_0924	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Swol_0925	COG1067	ATP-dependent peptidase activity
Swol_0927	COG0840	transmembrane signaling receptor activity
Swol_0927	COG3290	protein histidine kinase activity
Swol_0930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Swol_0934	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Swol_0935	COG0583	DNA-binding transcription factor activity
Swol_0939	COG0798	PFAM Bile acid sodium symporter
Swol_0940	COG0673	inositol 2-dehydrogenase activity
Swol_0941	COG1136	(ABC) transporter
Swol_0943	COG0577	efflux transmembrane transporter activity
Swol_0947	COG4786	Flagellar basal body rod
Swol_0948	COG1873	PFAM PRC-barrel domain
Swol_0949	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Swol_0951	COG0745	RESPONSE REGULATOR receiver
Swol_0952	COG5002	protein histidine kinase activity
Swol_0953	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Swol_0954	COG1799	cell septum assembly
Swol_0955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Swol_0957	COG0826	peptidase U32
Swol_0958	COG3599	regulation of cell shape
Swol_0959	COG1872	DUF167
Swol_0961	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Swol_0962	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Swol_0964	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Swol_0965	COG0438	transferase activity, transferring glycosyl groups
Swol_0970	COG4224	UPF0291 protein
Swol_0971	COG0840	transmembrane signaling receptor activity
Swol_0972	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Swol_0974	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Swol_0977	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Swol_0978	COG2136	Putative SAM-dependent methyltransferase
Swol_0978	COG2521	methyltransferase
Swol_0979	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Swol_0980	COG1923	regulation of RNA biosynthetic process
Swol_0983	COG0464	growth
Swol_0984	COG1373	ATPase (AAA superfamily
Swol_0999	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Swol_1000	COG0537	adenosine 5'-monophosphoramidase activity
Swol_1005	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Swol_1008	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Swol_1009	COG1598	PFAM Uncharacterised protein family UPF0150
Swol_1011	COG0037	tRNA processing
Swol_1012	COG0247	lactate metabolic process
Swol_1013	COG0277	FAD linked oxidase domain protein
Swol_1014	COG0427	acetyl-CoA hydrolase
Swol_1015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Swol_1019	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Swol_1020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Swol_1026	COG0303	'Molybdopterin
Swol_1028	COG3383	formate dehydrogenase (NAD+) activity
Swol_1030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Swol_1031	COG1183	phosphatidylcholine synthase activity
Swol_1035	COG3344	reverse transcriptase
Swol_1040	COG4191	Histidine kinase
Swol_1048	COG1882	Formate acetyltransferase
Swol_1050	COG1307	EDD domain protein, DegV family
Swol_1051	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Swol_1054	COG5002	protein histidine kinase activity
Swol_1064	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Swol_1068	COG0726	polysaccharide deacetylase
Swol_1069	COG0726	polysaccharide deacetylase
Swol_1070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Swol_1071	COG0765	amino acid transport
Swol_1072	COG1126	abc transporter atp-binding protein
Swol_1080	COG2909	trisaccharide binding
Swol_1082	COG2239	Acts as a magnesium transporter
Swol_1086	COG1404	Belongs to the peptidase S8 family
Swol_1088	COG4399	Belongs to the UPF0754 family
Swol_1089	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Swol_1091	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Swol_1092	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Swol_1093	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Swol_1094	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Swol_1095	COG0072	phenylalanine-tRNA ligase activity
Swol_1095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Swol_1099	COG3243	poly(R)-hydroxyalkanoic acid synthase
Swol_1100	COG0741	lytic transglycosylase activity
Swol_1101	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Swol_1104	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Swol_1105	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Swol_1105	COG1796	DNA polymerase
Swol_1106	COG2323	membrane
Swol_1107	COG0826	peptidase U32
Swol_1108	COG1193	negative regulation of DNA recombination
Swol_1110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Swol_1112	COG1435	thymidine kinase activity
Swol_1122	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Swol_1123	COG3285	dna ligase
Swol_1123	COG1793	dna ligase
Swol_1124	COG3285	dna ligase
Swol_1124	COG1793	dna ligase
Swol_1128	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Swol_1132	COG1199	ATP-dependent helicase activity
Swol_1138	COG3608	succinylglutamate desuccinylase aspartoacylase
Swol_1138	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Swol_1142	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Swol_1144	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Swol_1146	COG1074	ATP-dependent DNA helicase activity
Swol_1147	COG0427	acetyl-CoA hydrolase
Swol_1150	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Swol_1152	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Swol_1154	COG0668	transmembrane transport
Swol_1155	COG1181	Belongs to the D-alanine--D-alanine ligase family
Swol_1157	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Swol_1158	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Swol_1159	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Swol_1161	COG1615	UPF0182 protein
Swol_1164	COG1683	Conserved Protein
Swol_1169	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Swol_1171	COG1250	3-hydroxyacyl-CoA dehydrogenase
Swol_1173	COG0012	GTP binding
Swol_1174	COG0189	ligase activity
Swol_1178	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Swol_1178	COG4651	solute:proton antiporter activity
Swol_1185	COG1704	LemA family
Swol_1191	COG0583	DNA-binding transcription factor activity
Swol_1194	COG0697	spore germination
Swol_1198	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Swol_1199	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Swol_1203	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Swol_1205	COG0436	Aminotransferase
Swol_1206	COG1522	sequence-specific DNA binding
Swol_1210	COG0708	Exodeoxyribonuclease III
Swol_1214	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Swol_1216	COG0500	methyltransferase
Swol_1219	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Swol_1220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Swol_1220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Swol_1223	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Swol_1224	COG1162	GTPase activity
Swol_1225	COG2815	serine threonine protein kinase
Swol_1225	COG0515	serine threonine protein kinase
Swol_1227	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Swol_1228	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Swol_1228	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Swol_1229	COG2738	Putative neutral zinc metallopeptidase
Swol_1231	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Swol_1232	COG0242	peptide deformylase activity
Swol_1233	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Swol_1234	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Swol_1235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Swol_1236	COG1758	RNA polymerase activity
Swol_1237	COG0194	GDP metabolic process
Swol_1238	COG2052	Domain of unknown function (DUF370)
Swol_1239	COG1561	YicC-like family, N-terminal region
Swol_1240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Swol_1241	COG3243	poly(R)-hydroxyalkanoic acid synthase
Swol_1242	COG2030	dehydratase
Swol_1247	COG1388	LysM domain
Swol_1247	COG0791	NLP P60 protein
Swol_1248	COG0613	PHP domain protein
Swol_1250	COG2359	stage V sporulation protein S
Swol_1251	COG1692	metallophosphoesterase
Swol_1253	COG3344	reverse transcriptase
Swol_1254	COG1418	mRNA catabolic process
Swol_1255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Swol_1256	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Swol_1257	COG1058	Belongs to the CinA family
Swol_1257	COG1546	Belongs to the CinA family
Swol_1261	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Swol_1262	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Swol_1264	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Swol_1264	COG1522	sequence-specific DNA binding
Swol_1265	COG1674	ftsk spoiiie
Swol_1266	COG1968	undecaprenyl-diphosphatase activity
Swol_1267	COG0740	serine-type endopeptidase activity
Swol_1268	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Swol_1269	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Swol_1270	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Swol_1271	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Swol_1272	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Swol_1273	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Swol_1277	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Swol_1278	COG0284	orotidine-5'-phosphate decarboxylase activity
Swol_1279	COG0167	dihydroorotate dehydrogenase activity
Swol_1280	COG0543	2 iron, 2 sulfur cluster binding
Swol_1281	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Swol_1282	COG0505	Belongs to the CarA family
Swol_1283	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Swol_1284	COG0540	Belongs to the ATCase OTCase family
Swol_1285	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Swol_1286	COG0564	pseudouridine synthase activity
Swol_1287	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Swol_1290	COG4512	PFAM Accessory gene regulator B
Swol_1294	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Swol_1295	COG1959	2 iron, 2 sulfur cluster binding
Swol_1297	COG2361	Protein of unknown function DUF86
Swol_1299	COG4974	Belongs to the 'phage' integrase family
Swol_1300	COG0492	ferredoxin-NADP+ reductase activity
Swol_1301	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Swol_1316	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Swol_1318	COG0083	homoserine kinase activity
Swol_1319	COG0460	homoserine dehydrogenase
Swol_1322	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Swol_1323	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Swol_1324	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Swol_1327	COG0745	RESPONSE REGULATOR receiver
Swol_1329	COG2201	protein-glutamate methylesterase activity
Swol_1331	COG0840	transmembrane signaling receptor activity
Swol_1332	COG0643	Histidine kinase
Swol_1332	COG2198	Histidine kinase
Swol_1333	COG2201	protein-glutamate methylesterase activity
Swol_1341	COG1304	FMN binding
Swol_1344	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Swol_1344	COG0539	negative regulation of cytoplasmic translation
Swol_1346	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Swol_1347	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Swol_1348	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Swol_1349	COG0287	Prephenate dehydrogenase
Swol_1350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Swol_1350	COG0189	ligase activity
Swol_1351	COG4242	Belongs to the peptidase S51 family
Swol_1352	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Swol_1353	COG0723	plastoquinol--plastocyanin reductase activity
Swol_1353	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Swol_1354	COG2814	Major facilitator Superfamily
Swol_1355	COG2030	dehydratase
Swol_1356	COG2030	dehydratase
Swol_1357	COG1982	Orn Lys Arg decarboxylase major
Swol_1363	COG2378	regulation of single-species biofilm formation
Swol_1367	COG1131	(ABC) transporter
Swol_1374	COG1013	pyruvate-flavodoxin oxidoreductase activity
Swol_1375	COG0674	pyruvate-flavodoxin oxidoreductase activity
Swol_1377	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Swol_1381	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Swol_1382	COG1725	Transcriptional regulator
Swol_1388	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Swol_1390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Swol_1393	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Swol_1403	COG1639	'signal transduction protein
Swol_1406	COG1187	pseudouridine synthase activity
Swol_1408	COG0302	gtp cyclohydrolase
Swol_1409	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Swol_1412	COG0700	Nucleoside recognition
Swol_1413	COG2715	membrane protein required for spore maturation
Swol_1414	COG3874	Sporulation protein YtfJ
Swol_1417	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Swol_1418	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Swol_1419	COG1994	Peptidase M50
Swol_1420	COG0617	tRNA 3'-terminal CCA addition
Swol_1422	COG0019	diaminopimelate decarboxylase activity
Swol_1424	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Swol_1425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Swol_1427	COG1862	Preprotein translocase
Swol_1428	COG0343	queuine tRNA-ribosyltransferase activity
Swol_1429	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Swol_1430	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Swol_1431	COG2255	four-way junction helicase activity
Swol_1432	COG0632	four-way junction helicase activity
Swol_1433	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Swol_1435	COG0217	transcriptional regulatory protein
Swol_1436	COG2020	methyltransferase activity
Swol_1437	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Swol_1438	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Swol_1442	COG0646	methionine synthase
Swol_1442	COG1410	methionine synthase
Swol_1443	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Swol_1445	COG0606	chelatase, subunit chli
Swol_1446	COG1406	Chemotaxis phosphatase CheX
Swol_1448	COG2201	protein-glutamate methylesterase activity
Swol_1449	COG2201	protein-glutamate methylesterase activity
Swol_1450	COG0835	chemotaxis
Swol_1451	COG0840	transmembrane signaling receptor activity
Swol_1452	COG0443	Heat shock 70 kDa protein
Swol_1454	COG1192	Involved in chromosome partitioning
Swol_1455	COG0643	Histidine kinase
Swol_1455	COG2198	Histidine kinase
Swol_1457	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Swol_1468	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Swol_1472	COG1120	ATPase activity
Swol_1474	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Swol_1475	COG0792	nuclease activity
Swol_1476	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Swol_1478	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Swol_1481	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Swol_1483	COG1960	acyl-CoA dehydrogenase activity
Swol_1484	COG1024	Enoyl-CoA hydratase
Swol_1485	COG1250	3-hydroxyacyl-CoA dehydrogenase
Swol_1486	COG0183	Belongs to the thiolase family
Swol_1487	COG3290	protein histidine kinase activity
Swol_1487	COG3829	transcription factor binding
Swol_1490	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Swol_1491	COG0335	large ribosomal subunit rRNA binding
Swol_1492	COG4752	Belongs to the RNA methyltransferase TrmD family
Swol_1493	COG0336	Belongs to the RNA methyltransferase TrmD family
Swol_1494	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Swol_1496	COG1837	Belongs to the UPF0109 family
Swol_1497	COG0228	four-way junction DNA binding
Swol_1498	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Swol_1499	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Swol_1500	COG1307	EDD domain protein, DegV family
Swol_1505	COG1671	Belongs to the UPF0178 family
Swol_1507	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Swol_1508	COG0358	DNA primase activity
Swol_1512	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Swol_1512	COG0574	Belongs to the PEP-utilizing enzyme family
Swol_1513	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Swol_1514	COG0517	IMP dehydrogenase activity
Swol_1515	COG0751	glycine-tRNA ligase activity
Swol_1516	COG0752	glycyl-tRNA synthetase alpha subunit
Swol_1519	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Swol_1520	COG1333	cytochrome c biogenesis protein
Swol_1521	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Swol_1523	COG0778	Nitroreductase
Swol_1525	COG0398	Pfam SNARE associated Golgi protein
Swol_1538	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Swol_1539	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Swol_1541	COG1598	PFAM Uncharacterised protein family UPF0150
Swol_1554	COG3842	ATPase activity
Swol_1555	COG4149	molybdate abc transporter
Swol_1556	COG0725	ABC transporter, periplasmic molybdate-binding protein
Swol_1558	COG1381	Involved in DNA repair and RecF pathway recombination
Swol_1560	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Swol_1561	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Swol_1562	COG0295	cytidine deaminase activity
Swol_1563	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Swol_1564	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Swol_1565	COG1480	7TM receptor with intracellular HD hydrolase
Swol_1566	COG1702	phosphate starvation-inducible protein PhoH
Swol_1572	COG0537	adenosine 5'-monophosphoramidase activity
Swol_1573	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Swol_1574	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Swol_1575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Swol_1576	COG2264	protein methyltransferase activity
Swol_1578	COG0443	Heat shock 70 kDa protein
Swol_1581	COG1420	regulation of RNA biosynthetic process
Swol_1583	COG0481	GTPase activity
Swol_1584	COG0728	peptidoglycan biosynthetic process
Swol_1587	COG0268	Binds directly to 16S ribosomal RNA
Swol_1589	COG2050	protein possibly involved in aromatic compounds catabolism
Swol_1590	COG3263	regulation of cellular component size
Swol_1591	COG0402	S-adenosylhomocysteine deaminase activity
Swol_1593	COG0402	S-adenosylhomocysteine deaminase activity
Swol_1594	COG0737	Belongs to the 5'-nucleotidase family
Swol_1595	COG0658	competence protein
Swol_1595	COG2333	competence protein COMEC
Swol_1598	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Swol_1598	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Swol_1599	COG0495	leucyl-tRNA aminoacylation
Swol_1600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Swol_1601	COG0799	negative regulation of ribosome biogenesis
Swol_1602	COG1713	HD superfamily hydrolase involved in NAD metabolism
Swol_1603	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Swol_1605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Swol_1607	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Swol_1608	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Swol_1609	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Swol_1611	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Swol_1612	COG2868	ribosomal protein
Swol_1613	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Swol_1614	COG1530	ribonuclease E activity
Swol_1616	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Swol_1620	COG1131	(ABC) transporter
Swol_1621	COG1725	Transcriptional regulator
Swol_1622	COG5001	Diguanylate cyclase
Swol_1622	COG4251	negative regulation of phosphorylation
Swol_1622	COG2203	Gaf domain
Swol_1622	COG3706	GGDEF domain
Swol_1626	COG1979	alcohol dehydrogenase
Swol_1628	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Swol_1629	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Swol_1634	COG0772	Belongs to the SEDS family
Swol_1635	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Swol_1636	COG2894	cell division
Swol_1637	COG0850	regulation of cytokinetic process
Swol_1638	COG0768	penicillin binding
Swol_1641	COG1077	Cell shape determining protein MreB Mrl
Swol_1642	COG2003	Belongs to the UPF0758 family
Swol_1643	COG0424	maF-like protein
Swol_1645	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Swol_1646	COG0306	phosphate transporter
Swol_1648	COG0285	dihydrofolate synthase activity
Swol_1649	COG0525	valine-tRNA ligase activity
Swol_1651	COG0653	protein targeting
Swol_1652	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Swol_1653	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Swol_1654	COG1067	ATP-dependent peptidase activity
Swol_1654	COG0470	DNA polymerase III
Swol_1656	COG0740	serine-type endopeptidase activity
Swol_1657	COG0544	peptidyl-prolyl cis-trans isomerase activity
Swol_1659	COG0330	HflC and HflK could
Swol_1663	COG1376	ErfK ybiS ycfS ynhG family protein
Swol_1667	COG1073	alpha beta
Swol_1668	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Swol_1671	COG1970	mechanosensitive ion channel activity
Swol_1675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Swol_1680	COG2205	protein histidine kinase activity
Swol_1681	COG0745	RESPONSE REGULATOR receiver
Swol_1683	COG1136	(ABC) transporter
Swol_1683	COG0577	efflux transmembrane transporter activity
Swol_1686	COG2813	Specifically methylates the guanine in position
Swol_1693	COG0303	'Molybdopterin
Swol_1694	COG1120	ATPase activity
Swol_1698	COG2217	Heavy metal translocating P-type atpase
Swol_1703	COG2414	aldehyde ferredoxin oxidoreductase
Swol_1704	COG0437	4 iron, 4 sulfur cluster binding
Swol_1706	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Swol_1710	COG0658	competence protein
Swol_1710	COG2333	competence protein COMEC
Swol_1711	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Swol_1712	COG3944	biosynthesis protein
Swol_1715	COG1136	(ABC) transporter
Swol_1715	COG0577	efflux transmembrane transporter activity
Swol_1717	COG2304	oxidoreductase activity
Swol_1719	COG0714	Associated with various cellular activities
Swol_1723	COG1131	(ABC) transporter
Swol_1730	COG0419	ATPase involved in DNA repair
Swol_1731	COG0420	3'-5' exonuclease activity
Swol_1732	COG0793	Belongs to the peptidase S41A family
Swol_1733	COG0024	Methionine aminopeptidase
Swol_1735	COG0427	acetyl-CoA hydrolase
Swol_1736	COG4176	ABC-type proline glycine betaine transport system permease component
Swol_1737	COG4175	Glycine betaine
Swol_1737	COG0517	IMP dehydrogenase activity
Swol_1739	COG0765	amino acid transport
Swol_1740	COG1126	abc transporter atp-binding protein
Swol_1744	COG0427	acetyl-CoA hydrolase
Swol_1749	COG1468	defense response to virus
Swol_1749	COG1518	maintenance of DNA repeat elements
Swol_1754	COG1337	RAMP superfamily
Swol_1756	COG1353	crispr-associated protein
Swol_1758	COG2323	membrane
Swol_1760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Swol_1763	COG1253	flavin adenine dinucleotide binding
Swol_1765	COG0107	imidazoleglycerol-phosphate synthase activity
Swol_1766	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Swol_1767	COG0131	Imidazoleglycerol-phosphate dehydratase
Swol_1769	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Swol_1770	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Swol_1771	COG4496	protein, YerC YecD
Swol_1774	COG0151	Belongs to the GarS family
Swol_1775	COG0138	bifunctional purine biosynthesis protein purh
Swol_1776	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Swol_1777	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Swol_1778	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Swol_1780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Swol_1784	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Swol_1784	COG0519	Catalyzes the synthesis of GMP from XMP
Swol_1793	COG2208	phosphoserine phosphatase activity
Swol_1793	COG2770	Histidine kinase
Swol_1795	COG1366	Belongs to the anti-sigma-factor antagonist family
Swol_1796	COG3642	lipopolysaccharide core region biosynthetic process
Swol_1802	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Swol_1803	COG1518	maintenance of DNA repeat elements
Swol_1805	COG0556	nucleotide-excision repair
Swol_1811	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Swol_1813	COG0617	tRNA 3'-terminal CCA addition
Swol_1815	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Swol_1815	COG3608	succinylglutamate desuccinylase aspartoacylase
Swol_1817	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Swol_1821	COG1910	domain protein
Swol_1824	COG0437	4 iron, 4 sulfur cluster binding
Swol_1825	COG0243	molybdopterin cofactor binding
Swol_1825	COG3383	formate dehydrogenase (NAD+) activity
Swol_1827	COG0303	'Molybdopterin
Swol_1830	COG3383	formate dehydrogenase (NAD+) activity
Swol_1832	COG0437	4 iron, 4 sulfur cluster binding
Swol_1833	COG0446	pyridine nucleotide-disulphide oxidoreductase
Swol_1839	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Swol_1840	COG0840	transmembrane signaling receptor activity
Swol_1841	COG1960	acyl-CoA dehydrogenase activity
Swol_1844	COG1408	metallophosphoesterase
Swol_1845	COG0825	malonyl-CoA metabolic process
Swol_1846	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Swol_1847	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Swol_1848	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Swol_1849	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Swol_1851	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Swol_1853	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Swol_1855	COG0459	protein refolding
Swol_1856	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Swol_1857	COG0521	Mo-molybdopterin cofactor biosynthetic process
Swol_1859	COG0315	cyclic pyranopterin monophosphate synthase activity
Swol_1860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Swol_1864	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Swol_1866	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Swol_1867	COG0456	acetyltransferase
Swol_1868	COG1214	PFAM Peptidase M22, glycoprotease
Swol_1869	COG0802	atpase or kinase
Swol_1870	COG1573	uracil-dna glycosylase
Swol_1876	COG2337	Toxic component of a toxin-antitoxin (TA) module
Swol_1878	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Swol_1879	COG2337	Toxic component of a toxin-antitoxin (TA) module
Swol_1880	COG0864	Transcriptional regulator
Swol_1884	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Swol_1884	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Swol_1886	COG0835	chemotaxis
Swol_1888	COG1376	ErfK ybiS ycfS ynhG family protein
Swol_1889	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Swol_1890	COG1121	(ABC) transporter
Swol_1891	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
Swol_1893	COG0398	Pfam SNARE associated Golgi protein
Swol_1897	COG0513	Belongs to the DEAD box helicase family
Swol_1900	COG0438	transferase activity, transferring glycosyl groups
Swol_1901	COG1307	EDD domain protein, DegV family
Swol_1902	COG0446	pyridine nucleotide-disulphide oxidoreductase
Swol_1907	COG0756	dUTP diphosphatase activity
Swol_1908	COG1215	transferase activity, transferring glycosyl groups
Swol_1912	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Swol_1913	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Swol_1914	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Swol_1914	COG0662	Cupin 2, conserved barrel domain protein
Swol_1918	COG5002	protein histidine kinase activity
Swol_1919	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Swol_1920	COG1164	Oligoendopeptidase f
Swol_1921	COG1316	TRANSCRIPTIONal
Swol_1922	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Swol_1931	COG3290	protein histidine kinase activity
Swol_1931	COG3829	transcription factor binding
Swol_1932	COG0427	acetyl-CoA hydrolase
Swol_1933	COG1960	acyl-CoA dehydrogenase activity
Swol_1934	COG0183	Belongs to the thiolase family
Swol_1935	COG1250	3-hydroxyacyl-CoA dehydrogenase
Swol_1936	COG1024	Enoyl-CoA hydratase
Swol_1938	COG5002	protein histidine kinase activity
Swol_1942	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Swol_1945	COG1924	4 iron, 4 sulfur cluster binding
Swol_1947	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Swol_1948	COG1122	ATPase activity
Swol_1949	COG1122	ATPase activity
Swol_1951	COG1122	ATPase activity
Swol_1952	COG1122	ATPase activity
Swol_1956	COG1477	protein flavinylation
Swol_1974	COG0095	Lipoate-protein ligase
Swol_1977	COG3344	reverse transcriptase
Swol_1978	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Swol_1980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Swol_1981	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Swol_1982	COG0509	glycine decarboxylation via glycine cleavage system
Swol_1983	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Swol_1994	COG2135	peptidase activity
Swol_1995	COG0432	Pfam Uncharacterised protein family UPF0047
Swol_1997	COG2172	sigma factor antagonist activity
Swol_2004	COG1396	sequence-specific DNA binding
Swol_2010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Swol_2012	COG0747	negative chemotaxis
Swol_2013	COG0741	lytic transglycosylase activity
Swol_2014	COG0237	dephospho-CoA kinase activity
Swol_2015	COG1971	Probably functions as a manganese efflux pump
Swol_2016	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Swol_2020	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
Swol_2021	COG3191	aminopeptidase activity
Swol_2023	COG0463	Glycosyl transferase, family 2
Swol_2023	COG0457	Tetratricopeptide repeat
Swol_2030	COG1250	3-hydroxyacyl-CoA dehydrogenase
Swol_2031	COG1024	Enoyl-CoA hydratase
Swol_2033	COG1476	TRANSCRIPTIONal
Swol_2034	COG3070	regulator of competence-specific genes
Swol_2038	COG1131	(ABC) transporter
Swol_2041	COG0205	6-phosphofructokinase activity
Swol_2044	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Swol_2051	COG0183	Belongs to the thiolase family
Swol_2052	COG1960	acyl-CoA dehydrogenase activity
Swol_2053	COG3829	transcription factor binding
Swol_2053	COG3290	protein histidine kinase activity
Swol_2054	COG0426	domain, Protein
Swol_2058	COG1595	DNA-templated transcription, initiation
Swol_2060	COG2208	phosphoserine phosphatase activity
Swol_2064	COG1696	Membrane protein involved in D-alanine export
Swol_2065	COG2197	response regulator
Swol_2067	COG0464	growth
Swol_2071	COG0789	Transcriptional regulator
Swol_2075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Swol_2079	COG2801	Transposase and inactivated derivatives
Swol_2080	COG0560	Phosphoserine phosphatase
Swol_2083	COG0730	response to heat
Swol_2085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Swol_2087	COG0640	Transcriptional regulator
Swol_2090	COG1342	Belongs to the UPF0251 family
Swol_2091	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Swol_2092	COG3706	GGDEF domain
Swol_2093	COG0436	Aminotransferase
Swol_2095	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Swol_2100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Swol_2101	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Swol_2103	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Swol_2108	COG2385	sporulation resulting in formation of a cellular spore
Swol_2110	COG0411	ABC transporter
Swol_2112	COG0559	Belongs to the binding-protein-dependent transport system permease family
Swol_2115	COG0328	RNA-DNA hybrid ribonuclease activity
Swol_2122	COG2086	electron transfer activity
Swol_2123	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
Swol_2124	COG0644	oxidoreductase
Swol_2126	COG1960	acyl-CoA dehydrogenase activity
Swol_2127	COG1846	Transcriptional regulator
Swol_2128	COG0427	acetyl-CoA hydrolase
Swol_2129	COG1024	Enoyl-CoA hydratase
Swol_2131	COG0784	Response regulator, receiver
Swol_2132	COG4251	negative regulation of phosphorylation
Swol_2134	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Swol_2135	COG2081	HI0933 family
Swol_2137	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Swol_2139	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Swol_2140	COG0473	3-isopropylmalate dehydrogenase activity
Swol_2141	COG0066	3-isopropylmalate dehydratase activity
Swol_2142	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Swol_2143	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Swol_2144	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Swol_2145	COG0440	acetolactate synthase activity
Swol_2146	COG0028	Belongs to the TPP enzyme family
Swol_2150	COG2770	Histidine kinase
Swol_2150	COG3437	response regulator, receiver
Swol_2151	COG0840	transmembrane signaling receptor activity
Swol_2152	COG0840	transmembrane signaling receptor activity
Swol_2157	COG0463	Glycosyl transferase, family 2
Swol_2162	COG0840	transmembrane signaling receptor activity
Swol_2164	COG0778	Nitroreductase
Swol_2166	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Swol_2168	COG2703	oxygen carrier activity
Swol_2175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Swol_2177	COG0745	RESPONSE REGULATOR receiver
Swol_2184	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Swol_2190	COG1151	hydroxylamine reductase activity
Swol_2199	COG4695	Portal protein
Swol_2202	COG3436	PFAM IS66 Orf2 family protein
Swol_2203	COG4372	Transposase
Swol_2210	COG3436	PFAM IS66 Orf2 family protein
Swol_2211	COG4372	Transposase
Swol_2216	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Swol_2231	COG2274	protein secretion by the type I secretion system
Swol_2234	COG1013	pyruvate-flavodoxin oxidoreductase activity
Swol_2235	COG0674	pyruvate-flavodoxin oxidoreductase activity
Swol_2241	COG0393	Putative heavy-metal-binding
Swol_2243	COG1131	(ABC) transporter
Swol_2244	COG1725	Transcriptional regulator
Swol_2252	COG0582	viral genome integration into host DNA
Swol_2254	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Swol_2256	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Swol_2262	COG2003	Belongs to the UPF0758 family
Swol_2263	COG5377	YqaJ viral recombinase family
Swol_2267	COG4974	Belongs to the 'phage' integrase family
Swol_2271	COG3394	polysaccharide catabolic process
Swol_2281	COG4372	Transposase
Swol_2287	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Swol_2288	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Swol_2289	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Swol_2290	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Swol_2291	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Swol_2294	COG2078	PFAM AMMECR1 domain protein
Swol_2294	COG3885	ferrous iron binding
Swol_2295	COG0860	N-Acetylmuramoyl-L-alanine amidase
Swol_2297	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Swol_2298	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Swol_2299	COG0101	tRNA pseudouridine synthase activity
Swol_2300	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Swol_2301	COG1122	ATPase activity
Swol_2302	COG1122	ATPase activity
Swol_2303	COG0203	ribosomal protein L17
Swol_2304	COG0202	RNA polymerase activity
Swol_2305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Swol_2306	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Swol_2307	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Swol_2308	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Swol_2309	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Swol_2312	COG0563	adenylate kinase activity
Swol_2313	COG0201	protein transport
Swol_2314	COG0200	Binds to the 23S rRNA
Swol_2315	COG1841	ribosomal large subunit assembly
Swol_2316	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Swol_2317	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Swol_2318	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Swol_2319	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Swol_2321	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Swol_2322	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Swol_2323	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Swol_2324	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Swol_2325	COG0255	Belongs to the universal ribosomal protein uL29 family
Swol_2326	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Swol_2327	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Swol_2328	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Swol_2329	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Swol_2330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Swol_2331	COG0089	rRNA binding
Swol_2332	COG0088	Forms part of the polypeptide exit tunnel
Swol_2333	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Swol_2334	COG0051	transcription antitermination factor activity, RNA binding
Swol_2335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Swol_2336	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Swol_2337	COG0049	tRNA binding
Swol_2338	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Swol_2339	COG1358	cellular component organization or biogenesis
Swol_2340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Swol_2341	COG0085	RNA polymerase activity
Swol_2343	COG0222	ribosome binding
Swol_2344	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Swol_2345	COG0081	regulation of translation
Swol_2346	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Swol_2347	COG0250	Participates in transcription elongation, termination and antitermination
Swol_2349	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Swol_2350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Swol_2352	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Swol_2353	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Swol_2356	COG1045	serine acetyltransferase
Swol_2357	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Swol_2358	COG4086	secreted protein
Swol_2360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Swol_2361	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Swol_2362	COG4956	integral membrane protein (PIN domain superfamily)
Swol_2363	COG0426	domain, Protein
Swol_2365	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Swol_2366	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Swol_2367	COG0542	response to heat
Swol_2368	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Swol_2369	COG3880	PFAM UvrB UvrC protein
Swol_2373	COG4786	Flagellar basal body rod
Swol_2374	COG1077	Cell shape determining protein MreB Mrl
Swol_2375	COG1609	Transcriptional regulator
Swol_2376	COG2385	sporulation resulting in formation of a cellular spore
Swol_2377	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Swol_2381	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Swol_2382	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Swol_2384	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Swol_2385	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Swol_2386	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Swol_2387	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Swol_2388	COG0356	it plays a direct role in the translocation of protons across the membrane
Swol_2392	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Swol_2393	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Swol_2394	COG1971	Probably functions as a manganese efflux pump
Swol_2395	COG0009	L-threonylcarbamoyladenylate synthase
Swol_2396	COG2890	protein-(glutamine-N5) methyltransferase activity
Swol_2397	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Swol_2398	COG3872	metal-dependent enzyme
Swol_2399	COG0254	rRNA binding
Swol_2404	COG3481	metal-dependent phosphohydrolase, HD sub domain
Swol_2406	COG0739	heme binding
Swol_2407	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Swol_2408	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Swol_2409	COG1494	fructose-1,6-bisphosphatase
Swol_2410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Swol_2412	COG2204	response regulator
Swol_2415	COG0616	signal peptide processing
Swol_2416	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Swol_2418	COG0504	CTP synthase activity
Swol_2419	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Swol_2421	COG0018	arginyl-trna synthetase
Swol_2425	COG2210	Belongs to the sulfur carrier protein TusA family
Swol_2430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Swol_2431	COG2011	ABC-type metal ion transport system permease component
Swol_2433	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Swol_2438	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Swol_2439	COG1216	Glycosyl transferase, family 2
Swol_2441	COG0745	RESPONSE REGULATOR receiver
Swol_2443	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Swol_2447	COG1131	(ABC) transporter
Swol_2448	COG1131	(ABC) transporter
Swol_2449	COG0842	Transport permease protein
Swol_2450	COG1309	transcriptional regulator
Swol_2453	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Swol_2454	COG0528	UMP kinase activity
Swol_2456	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Swol_2457	COG1136	(ABC) transporter
Swol_2457	COG4591	ABC-type transport system involved in lipoprotein release permease component
Swol_2458	COG0577	efflux transmembrane transporter activity
Swol_2459	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Swol_2460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Swol_2464	COG0393	Putative heavy-metal-binding
Swol_2467	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Swol_2469	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Swol_2471	COG0492	ferredoxin-NADP+ reductase activity
Swol_2472	COG0739	heme binding
Swol_2476	COG1840	ABC-type Fe3 transport system, periplasmic component
Swol_2478	COG3842	ATPase activity
Swol_2479	COG1840	ABC-type Fe3 transport system, periplasmic component
Swol_2481	COG3842	ATPase activity
Swol_2497	COG3206	protein involved in exopolysaccharide biosynthesis
Swol_2498	COG1506	peptidase
Swol_2498	COG0823	Involved in the tonB-independent uptake of proteins
Swol_2515	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Swol_2516	COG1518	maintenance of DNA repeat elements
Swol_2533	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Swol_2534	COG1067	ATP-dependent peptidase activity
Swol_2534	COG0470	DNA polymerase III
Swol_2535	COG0359	binds to the 23S rRNA
Swol_2538	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Swol_2539	COG0629	single-stranded DNA binding
Swol_2540	COG0360	Binds together with S18 to 16S ribosomal RNA
Swol_2542	COG0709	Synthesizes selenophosphate from selenide and ATP
Swol_2543	COG1362	aminopeptidase activity
Swol_2545	COG0398	Pfam SNARE associated Golgi protein
Swol_2546	COG5002	protein histidine kinase activity
Swol_2547	COG2204	response regulator
Swol_2551	COG0517	IMP dehydrogenase activity
Swol_2553	COG0411	ABC transporter
Swol_2555	COG0559	Belongs to the binding-protein-dependent transport system permease family
Swol_2557	COG1924	4 iron, 4 sulfur cluster binding
Swol_2562	COG3949	Membrane
Swol_2565	COG0739	heme binding
Swol_2566	COG1024	Enoyl-CoA hydratase
Swol_2567	COG1475	DNA binding
Swol_2568	COG1192	Involved in chromosome partitioning
Swol_2569	COG1475	DNA binding
Swol_2570	COG0357	Ribosomal RNA small subunit methyltransferase G
Swol_2571	COG0445	tRNA wobble uridine modification
Swol_2572	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Swol_2573	COG1847	R3H domain protein
Swol_2575	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Swol_2576	COG0594	ribonuclease P activity
Swol_2577	COG0230	Belongs to the bacterial ribosomal protein bL34 family