locus-tag	class	description
A6070_00030	COG3246	L-lysine catabolic process to acetate
A6070_00040	COG0612	Peptidase, M16
A6070_00050	COG0113	porphobilinogen synthase activity
A6070_00055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6070_00055	COG1587	Uroporphyrinogen-III synthase
A6070_00060	COG0181	hydroxymethylbilane synthase activity
A6070_00065	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6070_00070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6070_00075	COG1648	precorrin-2 dehydrogenase activity
A6070_00075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6070_00080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6070_00085	COG3118	belongs to the thioredoxin family
A6070_00090	COG3028	Belongs to the UPF0307 family
A6070_00095	COG1490	D-aminoacyl-tRNA deacylase activity
A6070_00100	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A6070_00140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6070_00145	COG2264	protein methyltransferase activity
A6070_00165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6070_00170	COG1234	tRNA 3'-trailer cleavage
A6070_00180	COG2197	response regulator
A6070_00195	COG1592	Rubrerythrin
A6070_00210	COG4106	trans-aconitate 2-methyltransferase activity
A6070_00215	COG0500	methyltransferase
A6070_00245	COG0583	DNA-binding transcription factor activity
A6070_00255	COG2239	Acts as a magnesium transporter
A6070_00260	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6070_00265	COG2003	Belongs to the UPF0758 family
A6070_00270	COG0826	peptidase U32
A6070_00290	COG0840	transmembrane signaling receptor activity
A6070_00300	COG5002	protein histidine kinase activity
A6070_00330	COG1132	(ABC) transporter
A6070_00335	COG1132	(ABC) transporter
A6070_00340	COG2274	protein secretion by the type I secretion system
A6070_00360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6070_00365	COG1666	GTP binding
A6070_00375	COG2198	Histidine kinase
A6070_00375	COG0643	Histidine kinase
A6070_00385	COG0840	transmembrane signaling receptor activity
A6070_00390	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6070_00395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6070_00405	COG2226	methyltransferase
A6070_00410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6070_00425	COG0822	iron-sulfur transferase activity
A6070_00460	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6070_00465	COG0436	Aminotransferase
A6070_00475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6070_00485	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6070_00500	COG0187	DNA topoisomerase II activity
A6070_00505	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6070_00515	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6070_00520	COG0706	membrane insertase activity
A6070_00525	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6070_00530	COG0445	tRNA wobble uridine modification
A6070_00535	COG0357	Ribosomal RNA small subunit methyltransferase G
A6070_00540	COG1192	Involved in chromosome partitioning
A6070_00545	COG1475	DNA binding
A6070_00555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6070_00570	COG3572	ergothioneine biosynthetic process
A6070_00595	COG0606	chelatase, subunit chli
A6070_00625	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
A6070_00635	COG1269	ATP hydrolysis coupled proton transport
A6070_00650	COG1863	multisubunit Na H antiporter MnhE subunit
A6070_00675	COG1006	Multisubunit Na H antiporter MnhC subunit
A6070_00680	COG0651	ATP synthesis coupled electron transport
A6070_00695	COG0651	ATP synthesis coupled electron transport
A6070_00700	COG0589	response to stress
A6070_00715	COG1420	regulation of RNA biosynthetic process
A6070_00725	COG0443	Heat shock 70 kDa protein
A6070_00730	COG0484	heat shock protein binding
A6070_00740	COG1329	Transcriptional regulator
A6070_00745	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6070_00750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6070_00755	COG0215	cysteine-tRNA ligase activity
A6070_00760	COG0556	nucleotide-excision repair
A6070_00765	COG0842	Transport permease protein
A6070_00770	COG1131	(ABC) transporter
A6070_00775	COG2203	Gaf domain
A6070_00775	COG3706	GGDEF domain
A6070_00775	COG4251	negative regulation of phosphorylation
A6070_00775	COG5001	Diguanylate cyclase
A6070_00785	COG0805	protein transport
A6070_00790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6070_00795	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6070_00805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6070_00810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6070_00815	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6070_00820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6070_00825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6070_00830	COG0569	domain protein
A6070_00835	COG0628	permease
A6070_00845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6070_00855	COG1309	transcriptional regulator
A6070_00875	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6070_00880	COG0617	tRNA 3'-terminal CCA addition
A6070_00890	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6070_00895	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A6070_00915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6070_00915	COG0561	phosphatase activity
A6070_00930	COG0438	transferase activity, transferring glycosyl groups
A6070_00935	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A6070_00940	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A6070_00950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6070_00955	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A6070_00960	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6070_01005	COG0842	Transport permease protein
A6070_01005	COG1129	ABC transporter
A6070_01010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6070_01020	COG0577	efflux transmembrane transporter activity
A6070_01020	COG1136	(ABC) transporter
A6070_01035	COG1309	transcriptional regulator
A6070_01060	COG5002	protein histidine kinase activity
A6070_01075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6070_01100	COG1546	Belongs to the CinA family
A6070_01100	COG1058	Belongs to the CinA family
A6070_01120	COG4774	siderophore transport
A6070_01130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6070_01135	COG1120	ATPase activity
A6070_01175	COG2885	chlorophyll binding
A6070_01180	COG0823	Involved in the tonB-independent uptake of proteins
A6070_01200	COG1469	GTP cyclohydrolase I activity
A6070_01205	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6070_01225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6070_01230	COG3264	Mechanosensitive ion channel
A6070_01230	COG1196	nuclear chromosome segregation
A6070_01235	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6070_01265	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6070_01270	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6070_01275	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6070_01295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6070_01345	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6070_01355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6070_01370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6070_01385	COG2095	MarC family integral membrane protein
A6070_01395	COG2095	MarC family integral membrane protein
A6070_01405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6070_01425	COG1950	PFAM Membrane protein of
A6070_01435	COG1242	4 iron, 4 sulfur cluster binding
A6070_01440	COG0745	RESPONSE REGULATOR receiver
A6070_01445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6070_01465	COG0297	glycogen (starch) synthase activity
A6070_01480	COG0564	pseudouridine synthase activity
A6070_01500	COG1396	sequence-specific DNA binding
A6070_01505	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A6070_01510	COG0069	glutamate synthase activity
A6070_01510	COG0070	glutamate synthase
A6070_01510	COG0067	glutamate synthase
A6070_01515	COG0492	ferredoxin-NADP+ reductase activity
A6070_01525	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6070_01530	COG0567	Dehydrogenase, E1 component
A6070_01535	COG2205	protein histidine kinase activity
A6070_01535	COG2198	Histidine kinase
A6070_01535	COG0784	Response regulator, receiver
A6070_01555	COG1234	tRNA 3'-trailer cleavage
A6070_01560	COG1278	Cold shock
A6070_01585	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6070_01590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6070_01605	COG1100	Small GTP-binding protein
A6070_01610	COG3108	Peptidase M15
A6070_01640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6070_01645	COG1459	type II secretion system
A6070_01660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6070_01665	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A6070_01690	COG1063	alcohol dehydrogenase
A6070_01730	COG3284	Transcriptional regulator
A6070_01735	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6070_01745	COG2022	thiamine diphosphate biosynthetic process
A6070_01755	COG3199	ATP-NAD kinase
A6070_01760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6070_01765	COG0022	dehydrogenase e1 component
A6070_01775	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6070_01780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6070_01790	COG0778	Nitroreductase
A6070_01795	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6070_01800	COG0321	lipoyl(octanoyl) transferase activity
A6070_01805	COG0596	Alpha beta hydrolase
A6070_01815	COG1657	PFAM Prenyltransferase squalene oxidase
A6070_01835	COG0542	response to heat
A6070_01840	COG0745	RESPONSE REGULATOR receiver
A6070_01845	COG2205	protein histidine kinase activity
A6070_01855	COG0071	Belongs to the small heat shock protein (HSP20) family
A6070_01875	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6070_01880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6070_01900	COG0569	domain protein
A6070_01905	COG0745	RESPONSE REGULATOR receiver
A6070_01910	COG5002	protein histidine kinase activity
A6070_01965	COG0546	phosphoglycolate phosphatase activity
A6070_01970	COG0733	neurotransmitter:sodium symporter activity
A6070_01975	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6070_01980	COG0424	maF-like protein
A6070_01985	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A6070_02000	COG0758	DNA mediated transformation
A6070_02010	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A6070_02015	COG0826	peptidase U32
A6070_02020	COG1597	lipid kinase activity
A6070_02025	COG0494	nUDIX hydrolase
A6070_02035	COG0686	Belongs to the AlaDH PNT family
A6070_02040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6070_02060	COG1278	Cold shock
A6070_02065	COG2824	Alkylphosphonate utilization operon protein PhnA
A6070_02075	COG0791	NLP P60 protein
A6070_02090	COG1592	Rubrerythrin
A6070_02100	COG0426	domain, Protein
A6070_02105	COG0038	chloride channel
A6070_02120	COG0726	polysaccharide deacetylase
A6070_02120	COG1649	PFAM Uncharacterised BCR, COG1649
A6070_02125	COG1215	transferase activity, transferring glycosyl groups
A6070_02140	COG0668	transmembrane transport
A6070_02145	COG3842	ATPase activity
A6070_02150	COG4208	sulfate ABC transporter
A6070_02165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6070_02170	COG0459	protein refolding
A6070_02180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6070_02190	COG0277	FAD linked oxidase domain protein
A6070_02195	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6070_02205	COG0315	cyclic pyranopterin monophosphate synthase activity
A6070_02210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6070_02220	COG3852	Histidine kinase
A6070_02230	COG1454	alcohol dehydrogenase
A6070_02230	COG1012	belongs to the aldehyde dehydrogenase family
A6070_02245	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6070_02260	COG1127	ABC transporter
A6070_02265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6070_02270	COG4520	surface antigen
A6070_02290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6070_02350	COG0024	Methionine aminopeptidase
A6070_02355	COG2176	DNA-directed DNA polymerase activity
A6070_02370	COG2151	metal-sulfur cluster biosynthetic enzyme
A6070_02375	COG0840	transmembrane signaling receptor activity
A6070_02400	COG0662	Cupin 2, conserved barrel domain protein
A6070_02420	COG0069	glutamate synthase activity
A6070_02430	COG0004	ammonium transporteR
A6070_02435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6070_02440	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A6070_02455	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6070_02460	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6070_02465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6070_02470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6070_02475	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6070_02480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6070_02485	COG0799	negative regulation of ribosome biogenesis
A6070_02490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6070_02500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A6070_02505	COG1040	competence protein
A6070_02530	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6070_02540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6070_02565	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A6070_02565	COG0037	tRNA processing
A6070_02575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6070_02585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6070_02590	COG0280	phosphate acetyltransferase
A6070_02600	COG0509	glycine decarboxylation via glycine cleavage system
A6070_02615	COG0295	cytidine deaminase activity
A6070_02620	COG0242	peptide deformylase activity
A6070_02630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6070_02635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6070_02645	COG2897	thiosulfate sulfurtransferase activity
A6070_02660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6070_02670	COG0583	DNA-binding transcription factor activity
A6070_02675	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6070_02690	COG1607	acyl-coa hydrolase
A6070_02695	COG2414	aldehyde ferredoxin oxidoreductase
A6070_02710	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6070_02730	COG1993	acr, cog1993
A6070_02745	COG1012	belongs to the aldehyde dehydrogenase family
A6070_02755	COG0493	'glutamate synthase
A6070_02760	COG2186	Transcriptional regulator
A6070_02765	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A6070_02770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6070_02780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6070_02785	COG0741	lytic transglycosylase activity
A6070_02790	COG1408	metallophosphoesterase
A6070_02795	COG0730	response to heat
A6070_02810	COG1882	Formate acetyltransferase
A6070_02815	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6070_02820	COG2197	response regulator
A6070_02825	COG2197	response regulator
A6070_02830	COG5002	protein histidine kinase activity
A6070_02875	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6070_02880	COG1643	Atp-dependent helicase
A6070_02895	COG0840	transmembrane signaling receptor activity
A6070_02910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6070_02915	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6070_02925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6070_02925	COG2146	nitrite reductase [NAD(P)H] activity
A6070_02940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6070_02945	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6070_02960	COG0538	isocitrate dehydrogenase activity
A6070_02980	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6070_03015	COG1584	GPR1 FUN34 yaaH family protein
A6070_03020	COG0322	excinuclease ABC activity
A6070_03035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6070_03045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6070_03045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6070_03050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6070_03055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A6070_03090	COG4251	negative regulation of phosphorylation
A6070_03090	COG5001	Diguanylate cyclase
A6070_03090	COG2203	Gaf domain
A6070_03090	COG3706	GGDEF domain
A6070_03095	COG0513	Belongs to the DEAD box helicase family
A6070_03100	COG1280	lysine exporter protein (LysE YggA)
A6070_03110	COG0668	transmembrane transport
A6070_03125	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A6070_03130	COG2951	lytic endotransglycosylase activity
A6070_03140	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
A6070_03155	COG1606	tRNA processing
A6070_03160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6070_03170	COG0640	Transcriptional regulator
A6070_03200	COG0436	Aminotransferase
A6070_03205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6070_03210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6070_03225	COG0165	Argininosuccinate lyase
A6070_03230	COG0137	argininosuccinate synthase activity
A6070_03235	COG1714	RDD family
A6070_03240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6070_03245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6070_03250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6070_03255	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6070_03260	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6070_03275	COG1132	(ABC) transporter
A6070_03285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6070_03290	COG2137	regulation of response to DNA damage stimulus
A6070_03300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6070_03305	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A6070_03310	COG1058	Belongs to the CinA family
A6070_03310	COG1546	Belongs to the CinA family
A6070_03315	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6070_03320	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A6070_03325	COG1691	(AIR) carboxylase
A6070_03330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6070_03375	COG0811	peptide transport
A6070_03380	COG0848	biopolymer transport protein
A6070_03390	COG0644	oxidoreductase
A6070_03395	COG1509	lysine 2,3-aminomutase activity
A6070_03400	COG0528	UMP kinase activity
A6070_03410	COG0427	acetyl-CoA hydrolase
A6070_03420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6070_03430	COG0514	ATP-dependent DNA helicase (RecQ)
A6070_03435	COG0708	Exodeoxyribonuclease III
A6070_03455	COG1278	Cold shock
A6070_03460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6070_03465	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6070_03470	COG0166	Belongs to the GPI family
A6070_03475	COG2200	EAL domain
A6070_03475	COG2199	diguanylate cyclase activity
A6070_03475	COG2202	Pas domain
A6070_03490	COG0835	chemotaxis
A6070_03495	COG0840	transmembrane signaling receptor activity
A6070_03500	COG1720	tRNA m6t6A37 methyltransferase activity
A6070_03525	COG0564	pseudouridine synthase activity
A6070_03530	COG1196	nuclear chromosome segregation
A6070_03540	COG0552	protein localization to endoplasmic reticulum
A6070_03555	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6070_03565	COG1692	metallophosphoesterase
A6070_03570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6070_03675	COG2204	response regulator
A6070_03680	COG5000	phosphorelay sensor kinase activity
A6070_03685	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6070_03700	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6070_03715	COG0632	four-way junction helicase activity
A6070_03720	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6070_03725	COG0217	transcriptional regulatory protein
A6070_03730	COG1494	fructose-1,6-bisphosphatase
A6070_03735	COG0584	glycerophosphoryl diester phosphodiesterase
A6070_03740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6070_03750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6070_03770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6070_03775	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6070_03780	COG0497	DNA recombination
A6070_03785	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6070_03790	COG0739	heme binding
A6070_03795	COG0653	protein targeting
A6070_03800	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A6070_03805	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A6070_03810	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A6070_03830	COG0745	RESPONSE REGULATOR receiver
A6070_03835	COG0525	valine-tRNA ligase activity
A6070_03855	COG4608	Belongs to the ABC transporter superfamily
A6070_03860	COG0444	Belongs to the ABC transporter superfamily
A6070_03880	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6070_03885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6070_03910	COG0528	UMP kinase activity
A6070_03930	COG1882	Formate acetyltransferase
A6070_03945	COG1349	DNA-binding transcription factor activity
A6070_03950	COG0697	spore germination
A6070_03960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6070_03975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6070_03980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6070_03985	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6070_03990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6070_03995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6070_04000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6070_04005	COG0356	it plays a direct role in the translocation of protons across the membrane
A6070_04010	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6070_04020	COG1943	Transposase
A6070_04045	COG1857	crispr-associated protein
A6070_04060	COG2337	Toxic component of a toxin-antitoxin (TA) module
A6070_04070	COG1518	maintenance of DNA repeat elements
A6070_04075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6070_04090	COG0159	tryptophan synthase activity
A6070_04095	COG0133	tryptophan synthase activity
A6070_04100	COG2188	Transcriptional regulator
A6070_04110	COG2223	nitrite transmembrane transporter activity
A6070_04115	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6070_04120	COG0351	phosphomethylpyrimidine kinase
A6070_04120	COG0352	thiamine-phosphate diphosphorylase activity
A6070_04125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6070_04135	COG0138	bifunctional purine biosynthesis protein purh
A6070_04140	COG0151	Belongs to the GarS family
A6070_04145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6070_04150	COG1333	cytochrome c biogenesis protein
A6070_04155	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6070_04160	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6070_04170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6070_04175	COG0228	four-way junction DNA binding
A6070_04180	COG1837	Belongs to the UPF0109 family
A6070_04185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6070_04190	COG0336	Belongs to the RNA methyltransferase TrmD family
A6070_04195	COG4752	Belongs to the RNA methyltransferase TrmD family
A6070_04200	COG0335	large ribosomal subunit rRNA binding
A6070_04205	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6070_04210	COG0792	nuclease activity
A6070_04220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6070_04225	COG1254	Belongs to the acylphosphatase family
A6070_04230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6070_04235	COG4536	flavin adenine dinucleotide binding
A6070_04240	COG2001	Belongs to the MraZ family
A6070_04245	COG0275	rRNA processing
A6070_04250	COG4839	cell division protein FtsL
A6070_04260	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6070_04265	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6070_04270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6070_04275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6070_04280	COG0772	Belongs to the SEDS family
A6070_04285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6070_04290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6070_04295	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6070_04300	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6070_04305	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6070_04325	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6070_04330	COG0488	(ABC) transporter
A6070_04345	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A6070_04350	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6070_04355	COG0154	amidase activity
A6070_04360	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6070_04365	COG2885	chlorophyll binding
A6070_04365	COG3047	cAMP biosynthetic process
A6070_04370	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6070_04390	COG3852	Histidine kinase
A6070_04395	COG2204	response regulator
A6070_04405	COG4966	pilus assembly protein PilW
A6070_04440	COG4966	pilus assembly protein PilW
A6070_04460	COG0557	exoribonuclease II activity
A6070_04465	COG0196	riboflavin kinase activity
A6070_04470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6070_04475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6070_04485	COG1459	type II secretion system
A6070_04490	COG3852	Histidine kinase
A6070_04495	COG2204	response regulator
A6070_04500	COG4968	Prepilin-type N-terminal cleavage methylation domain
A6070_04520	COG1131	(ABC) transporter
A6070_04525	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A6070_04555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6070_04560	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6070_04575	COG0006	proline dipeptidase activity
A6070_04580	COG0511	ligase activity, forming carbon-carbon bonds
A6070_04585	COG0439	Biotin carboxylase
A6070_04605	COG0582	viral genome integration into host DNA
A6070_04675	COG0778	Nitroreductase
A6070_04675	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A6070_04695	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A6070_04710	COG0420	3'-5' exonuclease activity
A6070_04715	COG0419	ATPase involved in DNA repair
A6070_04725	COG2848	UPF0210 protein
A6070_04730	COG3830	Belongs to the UPF0237 family
A6070_04750	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A6070_04755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6070_04770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6070_04780	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6070_04790	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A6070_04795	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A6070_04845	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6070_04855	COG3842	ATPase activity
A6070_04860	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6070_04875	COG2409	Drug exporters of the RND superfamily
A6070_04905	COG1047	Peptidyl-prolyl cis-trans
A6070_04910	COG1047	Peptidyl-prolyl cis-trans
A6070_04915	COG0471	metal ion transport
A6070_04920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6070_04925	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A6070_04930	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6070_04940	COG0318	PFAM AMP-dependent synthetase and ligase
A6070_04945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6070_04955	COG0133	tryptophan synthase activity
A6070_04960	COG0697	spore germination
A6070_04965	COG1012	belongs to the aldehyde dehydrogenase family
A6070_04965	COG1454	alcohol dehydrogenase
A6070_04975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6070_04980	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6070_04985	COG1136	(ABC) transporter
A6070_04990	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6070_05000	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6070_05005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6070_05010	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6070_05025	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6070_05030	COG1132	(ABC) transporter
A6070_05035	COG1519	Transferase
A6070_05040	COG1663	tetraacyldisaccharide 4'-kinase activity
A6070_05045	COG2835	tetraacyldisaccharide 4'-kinase activity
A6070_05050	COG0859	PFAM glycosyl transferase family 9
A6070_05055	COG0859	PFAM glycosyl transferase family 9
A6070_05060	COG1215	transferase activity, transferring glycosyl groups
A6070_05065	COG1216	Glycosyl transferase, family 2
A6070_05070	COG0463	Glycosyl transferase, family 2
A6070_05090	COG1215	transferase activity, transferring glycosyl groups
A6070_05100	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6070_05105	COG0297	glycogen (starch) synthase activity
A6070_05115	COG0438	transferase activity, transferring glycosyl groups
A6070_05120	COG0515	serine threonine protein kinase
A6070_05140	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6070_05140	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6070_05145	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6070_05150	COG1561	YicC-like family, N-terminal region
A6070_05155	COG0194	GDP metabolic process
A6070_05160	COG1758	RNA polymerase activity
A6070_05170	COG0251	oxidation-reduction process
A6070_05175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6070_05185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6070_05190	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6070_05200	COG0543	2 iron, 2 sulfur cluster binding
A6070_05210	COG3620	sequence-specific DNA binding
A6070_05210	COG0617	tRNA 3'-terminal CCA addition
A6070_05210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6070_05215	COG1994	Peptidase M50
A6070_05220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6070_05225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6070_05230	COG1187	pseudouridine synthase activity
A6070_05240	COG3267	Type II secretory pathway component ExeA
A6070_05240	COG3409	Peptidoglycan-binding domain 1 protein
A6070_05245	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6070_05250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6070_05270	COG2983	Belongs to the UPF0260 family
A6070_05275	COG0033	Phosphoglucomutase
A6070_05310	COG1472	Belongs to the glycosyl hydrolase 3 family
A6070_05320	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A6070_05335	COG0741	lytic transglycosylase activity
A6070_05355	COG3842	ATPase activity
A6070_05360	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A6070_05365	COG4149	molybdate abc transporter
A6070_05380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6070_05385	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6070_05390	COG0047	phosphoribosylformylglycinamidine synthase activity
A6070_05400	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6070_05410	COG0126	phosphoglycerate kinase activity
A6070_05455	COG3123	guanosine phosphorylase activity
A6070_05470	COG0604	alcohol dehydrogenase
A6070_05580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6070_05585	COG0488	(ABC) transporter
A6070_05595	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A6070_05655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6070_05660	COG0640	Transcriptional regulator
A6070_05695	COG0501	Belongs to the peptidase M48B family
A6070_05700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6070_05710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6070_05715	COG1882	Formate acetyltransferase
A6070_05720	COG5002	protein histidine kinase activity
A6070_05725	COG2197	response regulator
A6070_05730	COG1509	lysine 2,3-aminomutase activity
A6070_05750	COG0571	ribonuclease III activity
A6070_05765	COG1160	GTP binding
A6070_05785	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6070_05790	COG0495	leucyl-tRNA aminoacylation
A6070_05805	COG0268	Binds directly to 16S ribosomal RNA
A6070_05810	COG0728	peptidoglycan biosynthetic process
A6070_05820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6070_05825	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6070_05830	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6070_05835	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6070_05840	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6070_05845	COG0072	phenylalanine-tRNA ligase activity
A6070_05860	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6070_05865	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6070_05870	COG1238	metal cluster binding
A6070_05875	COG4942	peptidase
A6070_05880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6070_05885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6070_05895	COG3956	TIGRFAM MazG family protein
A6070_05910	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6070_05915	COG0416	fatty acid biosynthetic process
A6070_05920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6070_05925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6070_05935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6070_05940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6070_05945	COG0698	ribose 5-phosphate isomerase
A6070_05950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6070_05955	COG2131	deaminase
A6070_05960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6070_05965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6070_05965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6070_05975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6070_05975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6070_05980	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6070_05985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6070_05995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6070_06000	COG2873	o-acetylhomoserine
A6070_06010	COG0776	regulation of translation
A6070_06020	COG1917	Cupin 2, conserved barrel domain protein
A6070_06025	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6070_06030	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6070_06040	COG1335	isochorismatase
A6070_06055	COG0489	protein tyrosine kinase activity
A6070_06055	COG3206	protein involved in exopolysaccharide biosynthesis
A6070_06080	COG0471	metal ion transport
A6070_06080	COG3273	potassium ion transport
A6070_06085	COG0175	sulfate reduction
A6070_06100	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6070_06120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6070_06165	COG0297	glycogen (starch) synthase activity
A6070_06185	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A6070_06205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6070_06235	COG2026	Addiction module toxin, RelE StbE family
A6070_06320	COG2361	Protein of unknown function DUF86
A6070_06370	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A6070_06375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6070_06390	COG3174	membrane
A6070_06395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6070_06400	COG2853	Lipoprotein
A6070_06415	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6070_06430	COG1331	Highly conserved protein containing a thioredoxin domain
A6070_06445	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6070_06450	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6070_06455	COG0326	Molecular chaperone. Has ATPase activity
A6070_06480	COG0463	Glycosyl transferase, family 2
A6070_06490	COG0463	Glycosyl transferase, family 2
A6070_06540	COG4964	Belongs to the GSP D family
A6070_06570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6070_06575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6070_06585	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6070_06590	COG0058	SHG alpha-glucan phosphorylase activity
A6070_06595	COG1959	2 iron, 2 sulfur cluster binding
A6070_06610	COG1074	ATP-dependent DNA helicase activity
A6070_06650	COG0084	hydrolase, TatD family'
A6070_06655	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6070_06655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6070_06660	COG1774	PSP1 C-terminal conserved region
A6070_06665	COG0470	DNA polymerase III
A6070_06670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6070_06685	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6070_06690	COG0740	serine-type endopeptidase activity
A6070_06695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6070_06730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6070_06760	COG2165	general secretion pathway protein
A6070_06765	COG4968	Prepilin-type N-terminal cleavage methylation domain
A6070_06770	COG2884	Cell division ATP-binding protein ftsE
A6070_06775	COG2177	Part of the ABC transporter FtsEX involved in
A6070_06780	COG4942	peptidase
A6070_06785	COG0793	Belongs to the peptidase S41A family
A6070_06790	COG2861	carbohydrate metabolic process
A6070_06795	COG1192	Involved in chromosome partitioning
A6070_06800	COG1570	exodeoxyribonuclease VII activity
A6070_06805	COG1722	exodeoxyribonuclease VII activity
A6070_06815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6070_06825	COG0824	Thioesterase
A6070_06835	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6070_06855	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A6070_06875	COG2207	Transcriptional regulator
A6070_06880	COG1979	alcohol dehydrogenase
A6070_06890	COG0434	BtpA family
A6070_06895	COG0157	Belongs to the NadC ModD family
A6070_06900	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A6070_06910	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
A6070_06915	COG0156	8-amino-7-oxononanoate synthase activity
A6070_06920	COG2267	carboxylic ester hydrolase activity
A6070_06925	COG2226	methyltransferase
A6070_06945	COG1227	inorganic diphosphatase activity
A6070_06945	COG0517	IMP dehydrogenase activity
A6070_06950	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6070_06955	COG0793	Belongs to the peptidase S41A family
A6070_06995	COG1355	regulation of microtubule-based process
A6070_07010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6070_07040	COG0617	tRNA 3'-terminal CCA addition
A6070_07040	COG1353	crispr-associated protein
A6070_07050	COG0720	synthase
A6070_07055	COG0602	queuosine metabolic process
A6070_07065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6070_07070	COG0742	ribosomal rna small subunit methyltransferase
A6070_07075	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6070_07110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6070_07120	COG1027	Aspartate ammonia-lyase
A6070_07125	COG1160	GTP binding
A6070_07145	COG0778	Nitroreductase
A6070_07170	COG0481	GTPase activity
A6070_07175	COG0681	Belongs to the peptidase S26 family
A6070_07180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A6070_07185	COG0540	Belongs to the ATCase OTCase family
A6070_07190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6070_07195	COG0505	Belongs to the CarA family
A6070_07205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6070_07215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6070_07225	COG2226	methyltransferase
A6070_07230	COG1115	amino acid carrier protein
A6070_07235	COG0318	PFAM AMP-dependent synthetase and ligase
A6070_07250	COG3848	Pyruvate phosphate dikinase
A6070_07250	COG0574	Belongs to the PEP-utilizing enzyme family
A6070_07270	COG0489	protein tyrosine kinase activity
A6070_07275	COG3383	formate dehydrogenase (NAD+) activity
A6070_07280	COG3383	formate dehydrogenase (NAD+) activity
A6070_07325	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A6070_07340	COG0248	Ppx GppA phosphatase
A6070_07340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6070_07350	COG0009	L-threonylcarbamoyladenylate synthase
A6070_07355	COG0756	dUTP diphosphatase activity
A6070_07360	COG0612	Peptidase, M16
A6070_07370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6070_07375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6070_07380	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6070_07385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6070_07395	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6070_07405	COG0195	Participates in both transcription termination and antitermination
A6070_07410	COG0779	Required for maturation of 30S ribosomal subunits
A6070_07415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6070_07450	COG1144	Oxidoreductase
A6070_07480	COG0489	protein tyrosine kinase activity
A6070_07500	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6070_07505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6070_07510	COG0318	PFAM AMP-dependent synthetase and ligase
A6070_07520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6070_07525	COG0367	asparagine synthase
A6070_07555	COG0438	transferase activity, transferring glycosyl groups
A6070_07585	COG4974	Belongs to the 'phage' integrase family
A6070_07595	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6070_07600	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6070_07605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6070_07615	COG1940	carbohydrate kinase activity
A6070_07620	COG0848	biopolymer transport protein
A6070_07625	COG0811	peptide transport
A6070_07650	COG1131	(ABC) transporter
A6070_07660	COG0628	permease
A6070_07680	COG3012	SEC-C Motif Domain Protein
A6070_07705	COG4942	peptidase
A6070_07800	COG4974	Belongs to the 'phage' integrase family
A6070_07805	COG2003	Belongs to the UPF0758 family
A6070_07860	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6070_07875	COG0402	S-adenosylhomocysteine deaminase activity
A6070_07880	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A6070_07885	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6070_07890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6070_07925	COG2116	formate transmembrane transporter activity
A6070_07930	COG0746	molybdenum cofactor guanylyltransferase activity
A6070_07935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6070_07940	COG4451	ribulose bisphosphate carboxylase, small
A6070_07940	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6070_07945	COG3383	formate dehydrogenase (NAD+) activity
A6070_07975	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A6070_07980	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A6070_07985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6070_07995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6070_08000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A6070_08005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6070_08010	COG2983	Belongs to the UPF0260 family
A6070_08015	COG2270	Major facilitator Superfamily
A6070_08030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6070_08035	COG0482	sulfurtransferase activity
A6070_08040	COG0822	iron-sulfur transferase activity
A6070_08045	COG1104	cysteine desulfurase activity
A6070_08050	COG1959	2 iron, 2 sulfur cluster binding
A6070_08055	COG1045	serine acetyltransferase
A6070_08065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6070_08080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6070_08090	COG0601	transmembrane transport
A6070_08115	COG1366	Belongs to the anti-sigma-factor antagonist family
A6070_08125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6070_08140	COG2050	protein possibly involved in aromatic compounds catabolism
A6070_08140	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A6070_08145	COG0776	regulation of translation
A6070_08155	COG0539	negative regulation of cytoplasmic translation
A6070_08155	COG2183	response to ionizing radiation
A6070_08160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6070_08165	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6070_08175	COG0287	Prephenate dehydrogenase
A6070_08180	COG1605	Chorismate mutase
A6070_08180	COG0077	Prephenate dehydratase
A6070_08185	COG0436	Aminotransferase
A6070_08190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6070_08190	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A6070_08195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6070_08200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6070_08205	COG1862	Preprotein translocase
A6070_08215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6070_08225	COG1032	radical SAM domain protein
A6070_08230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6070_08235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6070_08240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6070_08245	COG0101	tRNA pseudouridine synthase activity
A6070_08255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6070_08260	COG0473	3-isopropylmalate dehydrogenase activity
A6070_08265	COG0066	3-isopropylmalate dehydratase activity
A6070_08275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6070_08280	COG0688	phosphatidylethanolamine metabolic process
A6070_08285	COG0440	acetolactate synthase activity
A6070_08290	COG0028	Belongs to the TPP enzyme family
A6070_08295	COG0129	dihydroxy-acid dehydratase activity
A6070_08305	COG1214	PFAM Peptidase M22, glycoprotease
A6070_08320	COG4589	Belongs to the CDS family
A6070_08325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6070_08330	COG0233	cytoplasmic translational termination
A6070_08335	COG0528	UMP kinase activity
A6070_08340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6070_08345	COG0052	Belongs to the universal ribosomal protein uS2 family
A6070_08370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6070_08375	COG0640	Transcriptional regulator
A6070_08385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6070_08400	COG3716	PTS system mannose fructose sorbose family IID component
A6070_08420	COG1660	Displays ATPase and GTPase activities
A6070_08425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6070_08430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6070_08435	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A6070_08440	COG1137	ATPase activity
A6070_08455	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6070_08465	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6070_08475	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6070_08485	COG4771	TonB-dependent receptor
A6070_08510	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A6070_08520	COG0785	Cytochrome C biogenesis protein
A6070_08535	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A6070_08540	COG0330	HflC and HflK could
A6070_08550	COG2204	response regulator
A6070_08560	COG0318	PFAM AMP-dependent synthetase and ligase
A6070_08565	COG1285	pathogenesis
A6070_08570	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6070_08585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6070_08590	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6070_08630	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6070_08635	COG1959	2 iron, 2 sulfur cluster binding
A6070_08635	COG1295	ribonuclease BN
A6070_08645	COG0612	Peptidase, M16
A6070_08650	COG0612	Peptidase, M16
A6070_08655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6070_08660	COG0142	geranyltranstransferase activity
A6070_08670	COG0840	transmembrane signaling receptor activity
A6070_08675	COG1234	tRNA 3'-trailer cleavage
A6070_08695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6070_08700	COG3852	Histidine kinase
A6070_08715	COG0359	binds to the 23S rRNA
A6070_08725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6070_08730	COG0360	Binds together with S18 to 16S ribosomal RNA
A6070_08735	COG0012	GTP binding
A6070_08740	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A6070_08745	COG0193	aminoacyl-tRNA hydrolase activity
A6070_08750	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6070_08755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6070_08765	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6070_08775	COG0390	transport system, permease component
A6070_08780	COG1125	glycine betaine transport
A6070_08780	COG0517	IMP dehydrogenase activity
A6070_08785	COG1573	uracil-dna glycosylase
A6070_08795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6070_08800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6070_08805	COG3481	metal-dependent phosphohydrolase, HD sub domain
A6070_08810	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A6070_08815	COG4191	Histidine kinase
A6070_08820	COG0589	response to stress
A6070_08825	COG2204	response regulator
A6070_08845	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A6070_08850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6070_08855	COG0105	UTP biosynthetic process
A6070_08865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6070_08875	COG1388	LysM domain
A6070_08875	COG1376	ErfK ybiS ycfS ynhG family protein
A6070_08890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6070_08895	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6070_08900	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6070_08915	COG2217	Heavy metal translocating P-type atpase
A6070_08925	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A6070_08935	COG0488	(ABC) transporter
A6070_08940	COG1530	ribonuclease E activity
A6070_08945	COG2840	Smr protein MutS2
A6070_08955	COG0791	NLP P60 protein
A6070_08955	COG1388	LysM domain
A6070_08965	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6070_08985	COG0791	NLP P60 protein
A6070_09000	COG0303	'Molybdopterin
A6070_09005	COG3383	formate dehydrogenase (NAD+) activity
A6070_09020	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A6070_09035	COG1921	L-seryl-tRNASec selenium transferase activity
A6070_09050	COG0583	DNA-binding transcription factor activity
A6070_09055	COG1971	Probably functions as a manganese efflux pump
A6070_09065	COG0116	Belongs to the methyltransferase superfamily
A6070_09065	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6070_09070	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6070_09085	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6070_09090	COG1480	7TM receptor with intracellular HD hydrolase
A6070_09100	COG0148	phosphopyruvate hydratase activity
A6070_09135	COG1929	Belongs to the glycerate kinase type-1 family
A6070_09155	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6070_09160	COG0825	malonyl-CoA metabolic process
A6070_09165	COG0587	DNA-directed DNA polymerase activity
A6070_09170	COG0424	maF-like protein
A6070_09185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6070_09185	COG0519	Catalyzes the synthesis of GMP from XMP
A6070_09190	COG0516	GMP reductase activity
A6070_09190	COG0517	IMP dehydrogenase activity
A6070_09195	COG1363	Peptidase, m42
A6070_09200	COG0587	DNA-directed DNA polymerase activity
A6070_09205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6070_09220	COG1217	gtp-binding protein TYPA
A6070_09225	COG2078	PFAM AMMECR1 domain protein
A6070_09250	COG0745	RESPONSE REGULATOR receiver
A6070_09260	COG0745	RESPONSE REGULATOR receiver
A6070_09270	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A6070_09275	COG2201	protein-glutamate methylesterase activity
A6070_09285	COG0835	chemotaxis
A6070_09290	COG2198	Histidine kinase
A6070_09290	COG0643	Histidine kinase
A6070_09300	COG1815	bacterial-type flagellum-dependent cell motility
A6070_09310	COG1677	Flagellar hook-basal body complex protein FliE
A6070_09320	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6070_09325	COG1317	bacterial-type flagellum organization
A6070_09330	COG1157	protein secretion by the type III secretion system
A6070_09385	COG1233	COG1233 Phytoene dehydrogenase and related
A6070_09395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6070_09410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6070_09415	COG2267	carboxylic ester hydrolase activity
A6070_09435	COG0534	Mate efflux family protein
A6070_09440	COG1902	pentaerythritol trinitrate reductase activity
A6070_09460	COG0604	alcohol dehydrogenase
A6070_09475	COG1764	response to oxidative stress
A6070_09490	COG0590	tRNA wobble adenosine to inosine editing
A6070_09495	COG0028	Belongs to the TPP enzyme family
A6070_09515	COG1794	racemase activity, acting on amino acids and derivatives
A6070_09535	COG1013	pyruvate-flavodoxin oxidoreductase activity
A6070_09540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A6070_09540	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6070_09545	COG0425	Belongs to the sulfur carrier protein TusA family
A6070_09550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6070_09570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6070_09585	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
A6070_09590	COG5012	cobalamin binding
A6070_09610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6070_09650	COG3422	double-strand break repair
A6070_09670	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6070_09700	COG1338	Plays a role in the flagellum-specific transport system
A6070_09715	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6070_09720	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6070_09725	COG1419	protein localization to endoplasmic reticulum
A6070_09735	COG1191	sigma factor activity
A6070_09745	COG4786	Flagellar basal body rod
A6070_09750	COG4786	Flagellar basal body rod
A6070_09760	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6070_09765	COG1706	bacterial-type flagellum-dependent cell motility
A6070_09770	COG3951	Flagellar rod assembly protein muramidase FlgJ
A6070_09770	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6070_09785	COG4786	Flagellar basal body rod
A6070_09785	COG1256	bacterial-type flagellum assembly
A6070_09790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6070_09795	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A6070_09800	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A6070_09810	COG1083	cytidylyl-transferase
A6070_09825	COG2089	acid synthase
A6070_09835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6070_09840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6070_09845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6070_09850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6070_09865	COG1516	flagellar protein fliS
A6070_09895	COG2257	FlhB HrpN YscU SpaS Family
A6070_09915	COG2989	Protein conserved in bacteria
A6070_09920	COG1012	belongs to the aldehyde dehydrogenase family
A6070_09940	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6070_09965	COG2226	methyltransferase
A6070_09970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6070_09980	COG0537	adenosine 5'-monophosphoramidase activity
A6070_10000	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A6070_10010	COG2205	protein histidine kinase activity
A6070_10010	COG0784	Response regulator, receiver
A6070_10010	COG5002	protein histidine kinase activity
A6070_10020	COG2208	phosphoserine phosphatase activity
A6070_10035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6070_10045	COG1077	Cell shape determining protein MreB Mrl
A6070_10085	COG0124	histidyl-tRNA synthetase
A6070_10090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6070_10100	COG0538	isocitrate dehydrogenase activity
A6070_10105	COG0039	L-malate dehydrogenase activity
A6070_10130	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A6070_10130	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6070_10135	COG1013	pyruvate-flavodoxin oxidoreductase activity
A6070_10145	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6070_10165	COG0004	ammonium transporteR
A6070_10175	COG1067	ATP-dependent peptidase activity
A6070_10180	COG0586	Pfam SNARE associated Golgi protein
A6070_10185	COG2957	Belongs to the agmatine deiminase family
A6070_10190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6070_10195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6070_10215	COG3284	Transcriptional regulator
A6070_10220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6070_10230	COG1882	Formate acetyltransferase
A6070_10255	COG1024	Enoyl-CoA hydratase
A6070_10295	COG3505	Type IV secretory pathway VirD4
A6070_10310	COG2948	multi-organism process
A6070_10320	COG3736	Type IV secretory pathway, component VirB8
A6070_10350	COG3451	type IV secretory pathway VirB4
A6070_10395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6070_10405	COG0802	atpase or kinase
A6070_10420	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6070_10425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6070_10430	COG4856	YbbR-like protein
A6070_10435	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A6070_10440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6070_10445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6070_10450	COG0037	tRNA processing
A6070_10465	COG2252	PERMEase
A6070_10475	COG5002	protein histidine kinase activity
A6070_10480	COG2197	response regulator
A6070_10485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6070_10490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6070_10505	COG0582	viral genome integration into host DNA
A6070_10550	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A6070_10630	COG0714	Associated with various cellular activities
A6070_10650	COG2003	Belongs to the UPF0758 family
A6070_10665	COG4191	Histidine kinase
A6070_10665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6070_10730	COG1525	nuclease
A6070_10750	COG0280	phosphate acetyltransferase
A6070_10810	COG3961	Belongs to the TPP enzyme family
A6070_10820	COG2207	Transcriptional regulator
A6070_10825	COG0667	Aldo Keto reductase
A6070_10830	COG4221	oxidoreductase activity
A6070_10835	COG2814	Major facilitator Superfamily
A6070_10845	COG1073	alpha beta
A6070_10860	COG2272	Belongs to the type-B carboxylesterase lipase family
A6070_11010	COG3385	transposase activity
A6070_11055	COG2932	Transcriptional regulator
A6070_11120	COG0191	fructose-bisphosphate aldolase activity
A6070_11130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6070_11135	COG0116	Belongs to the methyltransferase superfamily
A6070_11160	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6070_11165	COG0330	HflC and HflK could
A6070_11170	COG0330	HflC and HflK could
A6070_11180	COG3706	GGDEF domain
A6070_11185	COG0671	phosphoesterase, PA-phosphatase related
A6070_11200	COG0189	ligase activity
A6070_11200	COG4067	protein conserved in archaea
A6070_11205	COG0189	ligase activity
A6070_11225	COG3012	SEC-C Motif Domain Protein
A6070_11225	COG1405	negative regulation of cell septum assembly
A6070_11230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6070_11245	COG1918	ferrous iron import across plasma membrane
A6070_11245	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A6070_11265	COG1131	(ABC) transporter
A6070_11290	COG0189	ligase activity
A6070_11290	COG0569	domain protein
A6070_11295	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A6070_11305	COG1151	hydroxylamine reductase activity
A6070_11315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6070_11330	COG1592	Rubrerythrin
A6070_11340	COG0753	catalase activity
A6070_11355	COG1136	(ABC) transporter
A6070_11355	COG0577	efflux transmembrane transporter activity
A6070_11360	COG1136	(ABC) transporter
A6070_11360	COG0577	efflux transmembrane transporter activity
A6070_11365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6070_11375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6070_11470	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A6070_11555	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6070_11645	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6070_11655	COG1278	Cold shock
A6070_11660	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A6070_11665	COG4149	molybdate abc transporter
A6070_11670	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6070_11705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6070_11715	COG0484	heat shock protein binding
A6070_11720	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6070_11725	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6070_11730	COG0535	radical SAM domain protein
A6070_11745	COG0745	RESPONSE REGULATOR receiver
A6070_11750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6070_11760	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6070_11765	COG1408	metallophosphoesterase
A6070_11770	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A6070_11775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6070_11785	COG1414	Transcriptional regulator
A6070_11795	COG0237	dephospho-CoA kinase activity
A6070_11815	COG0543	2 iron, 2 sulfur cluster binding
A6070_11820	COG0493	'glutamate synthase
A6070_11825	COG2204	response regulator
A6070_11840	COG0489	protein tyrosine kinase activity
A6070_11845	COG2894	cell division
A6070_11855	COG0489	protein tyrosine kinase activity
A6070_11870	COG0018	arginyl-trna synthetase
A6070_11885	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6070_11890	COG0285	dihydrofolate synthase activity
A6070_11895	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6070_11900	COG1573	uracil-dna glycosylase
A6070_11915	COG0134	indole-3-glycerol-phosphate synthase activity
A6070_11920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6070_11925	COG0512	Glutamine amidotransferase of anthranilate synthase
A6070_11935	COG0203	ribosomal protein L17
A6070_11940	COG0202	RNA polymerase activity
A6070_11945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6070_11950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6070_11955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6070_11965	COG0563	adenylate kinase activity
A6070_11970	COG0201	protein transport
A6070_11975	COG0200	Binds to the 23S rRNA
A6070_11980	COG1841	ribosomal large subunit assembly
A6070_11985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6070_11990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6070_11995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6070_12000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6070_12005	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6070_12010	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6070_12015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6070_12020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6070_12025	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6070_12030	COG0255	Belongs to the universal ribosomal protein uL29 family
A6070_12035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6070_12040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6070_12045	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6070_12050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6070_12055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6070_12060	COG0089	rRNA binding
A6070_12065	COG0088	Forms part of the polypeptide exit tunnel
A6070_12070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6070_12075	COG0051	transcription antitermination factor activity, RNA binding
A6070_12080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6070_12090	COG0049	tRNA binding
A6070_12095	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6070_12100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6070_12105	COG0085	RNA polymerase activity
A6070_12110	COG0222	ribosome binding
A6070_12115	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6070_12120	COG0081	regulation of translation
A6070_12125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6070_12135	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6070_12145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6070_12170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6070_12175	COG0284	orotidine-5'-phosphate decarboxylase activity
A6070_12185	COG0442	prolyl-tRNA aminoacylation
A6070_12190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6070_12205	COG0543	2 iron, 2 sulfur cluster binding
A6070_12245	COG0037	tRNA processing
A6070_12250	COG2414	aldehyde ferredoxin oxidoreductase
A6070_12280	COG0704	Plays a role in the regulation of phosphate uptake
A6070_12285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6070_12290	COG0573	inorganic phosphate transmembrane transporter activity
A6070_12295	COG0573	inorganic phosphate transmembrane transporter activity
A6070_12305	COG5002	protein histidine kinase activity
A6070_12350	COG3339	Conserved Protein
A6070_12440	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6070_12455	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6070_12460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6070_12465	COG0330	HflC and HflK could
A6070_12480	COG1968	undecaprenyl-diphosphatase activity
A6070_12485	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A6070_12495	COG0629	single-stranded DNA binding
A6070_12500	COG1215	transferase activity, transferring glycosyl groups
A6070_12505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6070_12520	COG2205	protein histidine kinase activity
A6070_12530	COG1368	sulfuric ester hydrolase activity
A6070_12545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6070_12605	COG4974	Belongs to the 'phage' integrase family
A6070_12610	COG0432	Pfam Uncharacterised protein family UPF0047
A6070_12615	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6070_12630	COG1872	DUF167
A6070_12640	COG0762	integral membrane protein
A6070_12645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6070_12670	COG2022	thiamine diphosphate biosynthetic process
A6070_12675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6070_12680	COG0352	thiamine-phosphate diphosphorylase activity
A6070_12685	COG3273	potassium ion transport
A6070_12685	COG0471	metal ion transport
A6070_12695	COG2860	membrane
A6070_12700	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6070_12705	COG1515	deoxyribonuclease V activity
A6070_12715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6070_12715	COG0574	Belongs to the PEP-utilizing enzyme family
A6070_12720	COG0751	glycine-tRNA ligase activity
A6070_12725	COG0752	glycyl-tRNA synthetase alpha subunit
A6070_12730	COG1381	Involved in DNA repair and RecF pathway recombination
A6070_12735	COG2239	Acts as a magnesium transporter
A6070_12755	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6070_12755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6070_12760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6070_12805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6070_12825	COG1671	Belongs to the UPF0178 family
A6070_12830	COG0488	(ABC) transporter
A6070_12850	COG0107	imidazoleglycerol-phosphate synthase activity
A6070_12860	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
A6070_12875	COG0573	inorganic phosphate transmembrane transporter activity
A6070_12880	COG0581	inorganic phosphate transmembrane transporter activity
A6070_12885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6070_12895	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6070_12915	COG2033	superoxide reductase activity
A6070_12925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6070_12935	COG1280	lysine exporter protein (LysE YggA)
A6070_12950	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6070_12965	COG2161	toxin-antitoxin pair type II binding
A6070_12990	COG2161	toxin-antitoxin pair type II binding
A6070_12995	COG4115	mRNA cleavage
A6070_13000	COG2161	toxin-antitoxin pair type II binding
A6070_13005	COG4115	mRNA cleavage
A6070_13010	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6070_13015	COG3657	addiction module killer protein
A6070_13030	COG0367	asparagine synthase
A6070_13105	COG1047	Peptidyl-prolyl cis-trans
A6070_13170	COG0358	DNA primase activity
A6070_13175	COG1193	negative regulation of DNA recombination
A6070_13190	COG0140	phosphoribosyl-ATP diphosphatase activity
A6070_13195	COG0107	imidazoleglycerol-phosphate synthase activity
A6070_13200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6070_13210	COG0131	Imidazoleglycerol-phosphate dehydratase
A6070_13220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6070_13225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6070_13230	COG2890	protein-(glutamine-N5) methyltransferase activity
A6070_13235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6070_13240	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A6070_13245	COG0254	rRNA binding
A6070_13250	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6070_13270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6070_13275	COG2226	methyltransferase
A6070_13285	COG1119	ATPase activity
A6070_13295	COG5001	Diguanylate cyclase
A6070_13320	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6070_13320	COG0731	radical SAM domain protein
A6070_13325	COG0489	protein tyrosine kinase activity
A6070_13340	COG0598	Magnesium transport protein CorA
A6070_13350	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6070_13350	COG3264	Mechanosensitive ion channel
A6070_13360	COG2204	response regulator
A6070_13365	COG3958	Transketolase
A6070_13370	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6070_13380	COG1410	methionine synthase
A6070_13380	COG0646	methionine synthase
A6070_13390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6070_13415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6070_13420	COG2814	Major facilitator Superfamily
A6070_13430	COG0433	COG0433 Predicted ATPase
A6070_13450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6070_13475	COG1704	LemA family
A6070_13480	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A6070_13490	COG1323	Belongs to the UPF0348 family
A6070_13495	COG1489	DNA binding
A6070_13500	COG3830	Belongs to the UPF0237 family
A6070_13500	COG0560	Phosphoserine phosphatase
A6070_13520	COG0346	lactoylglutathione lyase activity
A6070_13545	COG2204	response regulator
A6070_13555	COG2205	protein histidine kinase activity
A6070_13580	COG4303	Ethanolamine ammonia lyase large subunit
A6070_13605	COG4302	ethanolamine ammonia-lyase activity
A6070_13615	COG1120	ATPase activity
A6070_13625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6070_13630	COG0714	Associated with various cellular activities
A6070_13675	COG4206	TonB-dependent receptor
A6070_13695	COG2853	Lipoprotein
A6070_13710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6070_13720	COG1053	succinate dehydrogenase
A6070_13730	COG0840	transmembrane signaling receptor activity
A6070_13740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6070_13750	COG0488	(ABC) transporter
A6070_13780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6070_13790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6070_13795	COG0840	transmembrane signaling receptor activity
A6070_13840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6070_13840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6070_13845	COG4869	propanediol catabolic process
A6070_13855	COG3385	transposase activity
A6070_13880	COG3284	Transcriptional regulator
A6070_13935	COG1061	Type III restriction enzyme res subunit
A6070_13940	COG0494	nUDIX hydrolase
A6070_13955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6070_13980	COG1454	alcohol dehydrogenase
A6070_13990	COG2204	response regulator
A6070_13995	COG0280	phosphate acetyltransferase
A6070_14000	COG3426	butyrate kinase activity
A6070_14005	COG4191	Histidine kinase
A6070_14025	COG3961	Belongs to the TPP enzyme family
A6070_14030	COG2121	Domain of unknown function (DUF374)
A6070_14035	COG0438	transferase activity, transferring glycosyl groups
A6070_14050	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A6070_14055	COG1151	hydroxylamine reductase activity
A6070_14065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6070_14095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6070_14105	COG0114	fumarate hydratase activity
A6070_14110	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6070_14115	COG1194	a g-specific adenine glycosylase
A6070_14120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6070_14125	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6070_14130	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6070_14135	COG0163	prenyltransferase activity
A6070_14145	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A6070_14150	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A6070_14155	COG4520	surface antigen
A6070_14160	COG1993	acr, cog1993
A6070_14165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6070_14190	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6070_14210	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
A6070_14220	COG2911	Protein conserved in bacteria
A6070_14225	COG0729	surface antigen
A6070_14245	COG3901	Regulator of nitric oxide reductase transcription
A6070_14245	COG0348	domain, Protein
A6070_14255	COG0531	amino acid
A6070_14260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6070_14275	COG4771	TonB-dependent receptor
A6070_14300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6070_14315	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A6070_14320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6070_14335	COG0328	RNA-DNA hybrid ribonuclease activity
A6070_14340	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6070_14345	COG0649	NAD binding
A6070_14345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6070_14355	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A6070_14360	COG1034	ATP synthesis coupled electron transport
A6070_14365	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6070_14370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6070_14375	COG0839	Belongs to the complex I subunit 6 family
A6070_14380	COG0713	ATP synthesis coupled electron transport
A6070_14385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6070_14390	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6070_14400	COG1007	ATP synthesis coupled electron transport
A6070_14460	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A6070_14480	COG4149	molybdate abc transporter
A6070_14500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6070_14505	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6070_14515	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6070_14520	COG0646	methionine synthase
A6070_14520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6070_14530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6070_14535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6070_14535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6070_14540	COG0501	Belongs to the peptidase M48B family
A6070_14555	COG0242	peptide deformylase activity
A6070_14560	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6070_14565	COG0045	succinate-CoA ligase (ADP-forming) activity
A6070_14570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6070_14580	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6070_14590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6070_14605	COG1454	alcohol dehydrogenase
A6070_14615	COG0303	'Molybdopterin
A6070_14635	COG4660	Part of a membrane complex involved in electron transport
A6070_14645	COG4658	electron transport chain
A6070_14650	COG4656	Part of a membrane complex involved in electron transport
A6070_14660	COG4657	Part of a membrane complex involved in electron transport
A6070_14665	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A6070_14670	COG0577	efflux transmembrane transporter activity
A6070_14670	COG1136	(ABC) transporter
A6070_14680	COG0577	efflux transmembrane transporter activity
A6070_14680	COG1136	(ABC) transporter
A6070_14685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6070_14695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6070_14700	COG4399	Belongs to the UPF0754 family
A6070_14720	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6070_14725	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6070_14730	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A6070_14740	COG0590	tRNA wobble adenosine to inosine editing
A6070_14755	COG3246	L-lysine catabolic process to acetate
A6070_14765	COG0612	Peptidase, M16
A6070_14775	COG0113	porphobilinogen synthase activity