locus-tag	class	description
Slip_0002	COG0592	DNA-directed DNA polymerase activity
Slip_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Slip_0005	COG0187	DNA topoisomerase II activity
Slip_0006	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Slip_0007	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Slip_0008	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Slip_0010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Slip_0011	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Slip_0012	COG0590	tRNA wobble adenosine to inosine editing
Slip_0016	COG3437	response regulator, receiver
Slip_0016	COG0784	Response regulator, receiver
Slip_0017	COG2703	oxygen carrier activity
Slip_0025	COG0457	Tetratricopeptide repeat
Slip_0025	COG0463	Glycosyl transferase, family 2
Slip_0033	COG2391	methyltransferase activity
Slip_0034	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Slip_0035	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Slip_0036	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Slip_0045	COG1982	Orn Lys Arg decarboxylase major
Slip_0046	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Slip_0049	COG1774	PSP1 C-terminal conserved region
Slip_0051	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Slip_0052	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Slip_0053	COG2002	toxin-antitoxin pair type II binding
Slip_0054	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Slip_0054	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Slip_0055	COG0084	hydrolase, TatD family'
Slip_0056	COG3583	domain protein
Slip_0056	COG3584	3D domain protein
Slip_0058	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Slip_0059	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Slip_0061	COG4466	Protein conserved in bacteria
Slip_0065	COG1752	Esterase of the alpha-beta hydrolase superfamily
Slip_0069	COG3481	metal-dependent phosphohydrolase, HD sub domain
Slip_0071	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Slip_0079	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Slip_0091	COG1136	(ABC) transporter
Slip_0091	COG4591	ABC-type transport system involved in lipoprotein release permease component
Slip_0092	COG0577	efflux transmembrane transporter activity
Slip_0092	COG1136	(ABC) transporter
Slip_0096	COG5002	protein histidine kinase activity
Slip_0097	COG0745	RESPONSE REGULATOR receiver
Slip_0098	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Slip_0099	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Slip_0101	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Slip_0102	COG1802	Transcriptional regulator
Slip_0104	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Slip_0105	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Slip_0106	COG0193	aminoacyl-tRNA hydrolase activity
Slip_0108	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Slip_0109	COG2002	toxin-antitoxin pair type II binding
Slip_0110	COG2244	polysaccharide biosynthetic process
Slip_0111	COG3956	TIGRFAM MazG family protein
Slip_0112	COG0776	regulation of translation
Slip_0113	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Slip_0118	COG1098	S1 RNA binding domain
Slip_0119	COG0248	Ppx GppA phosphatase
Slip_0121	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Slip_0123	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Slip_0126	COG2208	phosphoserine phosphatase activity
Slip_0127	COG0037	tRNA processing
Slip_0129	COG0105	UTP biosynthetic process
Slip_0130	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Slip_0131	COG1418	mRNA catabolic process
Slip_0132	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Slip_0133	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Slip_0134	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Slip_0135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Slip_0136	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Slip_0137	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Slip_0138	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Slip_0139	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Slip_0140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Slip_0143	COG3191	aminopeptidase activity
Slip_0144	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Slip_0145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Slip_0149	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Slip_0150	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Slip_0151	COG0445	tRNA wobble uridine modification
Slip_0157	COG1598	PFAM Uncharacterised protein family UPF0150
Slip_0158	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Slip_0159	COG1316	TRANSCRIPTIONal
Slip_0165	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Slip_0166	COG1216	Glycosyl transferase, family 2
Slip_0169	COG1368	sulfuric ester hydrolase activity
Slip_0172	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Slip_0173	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Slip_0175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Slip_0187	COG0330	HflC and HflK could
Slip_0202	COG1028	Short-chain dehydrogenase reductase Sdr
Slip_0208	COG0728	peptidoglycan biosynthetic process
Slip_0215	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Slip_0216	COG1333	cytochrome c biogenesis protein
Slip_0219	COG1122	ATPase activity
Slip_0220	COG1122	ATPase activity
Slip_0221	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Slip_0223	COG3976	FMN-binding domain protein
Slip_0223	COG1053	succinate dehydrogenase
Slip_0226	COG0577	efflux transmembrane transporter activity
Slip_0227	COG1136	(ABC) transporter
Slip_0228	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Slip_0232	COG0656	L-ascorbic acid biosynthetic process
Slip_0233	COG1979	alcohol dehydrogenase
Slip_0235	COG1309	transcriptional regulator
Slip_0237	COG1131	(ABC) transporter
Slip_0238	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Slip_0239	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Slip_0242	COG1592	Rubrerythrin
Slip_0243	COG0351	phosphomethylpyrimidine kinase
Slip_0243	COG0352	thiamine-phosphate diphosphorylase activity
Slip_0244	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Slip_0245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Slip_0246	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Slip_0249	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Slip_0250	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Slip_0251	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Slip_0252	COG0649	NAD binding
Slip_0253	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Slip_0254	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Slip_0257	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Slip_0258	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Slip_0259	COG1007	ATP synthesis coupled electron transport
Slip_0260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Slip_0262	COG0668	transmembrane transport
Slip_0276	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Slip_0282	COG3290	protein histidine kinase activity
Slip_0282	COG3829	transcription factor binding
Slip_0284	COG0183	Belongs to the thiolase family
Slip_0285	COG1250	3-hydroxyacyl-CoA dehydrogenase
Slip_0286	COG1960	acyl-CoA dehydrogenase activity
Slip_0287	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Slip_0288	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Slip_0290	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Slip_0298	COG0697	spore germination
Slip_0305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Slip_0309	COG1959	2 iron, 2 sulfur cluster binding
Slip_0310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Slip_0311	COG0544	peptidyl-prolyl cis-trans isomerase activity
Slip_0312	COG0740	serine-type endopeptidase activity
Slip_0314	COG1067	ATP-dependent peptidase activity
Slip_0314	COG0470	DNA polymerase III
Slip_0315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Slip_0316	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Slip_0319	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Slip_0320	COG4475	Protein of unknown function (DUF436)
Slip_0322	COG1879	ABC-type sugar transport system periplasmic component
Slip_0323	COG5012	cobalamin binding
Slip_0325	COG1172	Belongs to the binding-protein-dependent transport system permease family
Slip_0327	COG3693	PFAM glycoside hydrolase, family 10
Slip_0336	COG1342	Belongs to the UPF0251 family
Slip_0339	COG2894	cell division
Slip_0346	COG2720	vancomycin resistance protein
Slip_0350	COG3118	belongs to the thioredoxin family
Slip_0352	COG0482	sulfurtransferase activity
Slip_0355	COG0628	permease
Slip_0356	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Slip_0357	COG4472	Bacterial protein of unknown function (DUF965)
Slip_0359	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Slip_0360	COG3906	Belongs to the UPF0473 family
Slip_0361	COG2720	vancomycin resistance protein
Slip_0362	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Slip_0365	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Slip_0366	COG0768	penicillin binding
Slip_0367	COG0745	RESPONSE REGULATOR receiver
Slip_0368	COG5002	protein histidine kinase activity
Slip_0369	COG0573	inorganic phosphate transmembrane transporter activity
Slip_0370	COG0573	inorganic phosphate transmembrane transporter activity
Slip_0371	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Slip_0372	COG0704	Plays a role in the regulation of phosphate uptake
Slip_0374	COG1122	ATPase activity
Slip_0376	COG0310	cobalt ion transport
Slip_0377	COG0310	cobalt ion transport
Slip_0381	COG3290	protein histidine kinase activity
Slip_0382	COG3279	Response regulator of the LytR AlgR family
Slip_0383	COG0375	protein maturation
Slip_0384	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Slip_0388	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Slip_0389	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Slip_0393	COG1191	sigma factor activity
Slip_0394	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Slip_0395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Slip_0397	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
Slip_0398	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Slip_0399	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Slip_0400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Slip_0401	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Slip_0406	COG0312	modulator of DNA gyrase
Slip_0407	COG0312	modulator of DNA gyrase
Slip_0408	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Slip_0409	COG0006	proline dipeptidase activity
Slip_0410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Slip_0412	COG1847	R3H domain protein
Slip_0414	COG3854	ATPases associated with a variety of cellular activities
Slip_0423	COG0439	Biotin carboxylase
Slip_0424	COG1302	Protein conserved in bacteria
Slip_0427	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Slip_0428	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Slip_0429	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Slip_0430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Slip_0431	COG1570	exodeoxyribonuclease VII activity
Slip_0434	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Slip_0435	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Slip_0436	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Slip_0437	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Slip_0438	COG1438	arginine binding
Slip_0439	COG0497	DNA recombination
Slip_0440	COG0750	zinc metalloprotease
Slip_0441	COG0745	RESPONSE REGULATOR receiver
Slip_0442	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Slip_0447	COG2195	Cleaves the N-terminal amino acid of tripeptides
Slip_0452	COG1379	DNA repair
Slip_0454	COG1846	Transcriptional regulator
Slip_0455	COG1960	acyl-CoA dehydrogenase activity
Slip_0457	COG0644	oxidoreductase
Slip_0459	COG2086	electron transfer activity
Slip_0460	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Slip_0461	COG1024	Enoyl-CoA hydratase
Slip_0462	COG0427	acetyl-CoA hydrolase
Slip_0465	COG0183	Belongs to the thiolase family
Slip_0466	COG1028	Short-chain dehydrogenase reductase Sdr
Slip_0470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Slip_0473	COG0840	transmembrane signaling receptor activity
Slip_0475	COG0318	PFAM AMP-dependent synthetase and ligase
Slip_0477	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Slip_0479	COG0183	Belongs to the thiolase family
Slip_0481	COG1960	acyl-CoA dehydrogenase activity
Slip_0482	COG1250	3-hydroxyacyl-CoA dehydrogenase
Slip_0484	COG1028	Short-chain dehydrogenase reductase Sdr
Slip_0485	COG1024	Enoyl-CoA hydratase
Slip_0486	COG1024	Enoyl-CoA hydratase
Slip_0490	COG1024	Enoyl-CoA hydratase
Slip_0491	COG1300	Membrane
Slip_0493	COG4974	Belongs to the 'phage' integrase family
Slip_0494	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Slip_0496	COG0517	IMP dehydrogenase activity
Slip_0497	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Slip_0500	COG0427	acetyl-CoA hydrolase
Slip_0501	COG1960	acyl-CoA dehydrogenase activity
Slip_0502	COG1024	Enoyl-CoA hydratase
Slip_0503	COG1250	3-hydroxyacyl-CoA dehydrogenase
Slip_0504	COG3290	protein histidine kinase activity
Slip_0504	COG3829	transcription factor binding
Slip_0505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Slip_0506	COG0154	amidase activity
Slip_0507	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Slip_0508	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Slip_0509	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Slip_0510	COG0066	3-isopropylmalate dehydratase activity
Slip_0511	COG0538	isocitrate dehydrogenase activity
Slip_0515	COG1032	radical SAM domain protein
Slip_0516	COG0745	RESPONSE REGULATOR receiver
Slip_0516	COG3706	GGDEF domain
Slip_0517	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Slip_0519	COG0297	glycogen (starch) synthase activity
Slip_0520	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Slip_0521	COG1074	ATP-dependent DNA helicase activity
Slip_0523	COG0419	ATPase involved in DNA repair
Slip_0524	COG1686	Belongs to the peptidase S11 family
Slip_0526	COG2172	sigma factor antagonist activity
Slip_0527	COG1191	sigma factor activity
Slip_0529	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Slip_0533	COG1924	4 iron, 4 sulfur cluster binding
Slip_0534	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Slip_0535	COG0019	diaminopimelate decarboxylase activity
Slip_0536	COG0617	tRNA 3'-terminal CCA addition
Slip_0537	COG1994	Peptidase M50
Slip_0538	COG0180	Tryptophanyl-tRNA synthetase
Slip_0539	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Slip_0540	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Slip_0547	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Slip_0548	COG0726	polysaccharide deacetylase
Slip_0552	COG3874	Sporulation protein YtfJ
Slip_0553	COG2715	membrane protein required for spore maturation
Slip_0554	COG0700	Nucleoside recognition
Slip_0557	COG1573	uracil-dna glycosylase
Slip_0558	COG0802	atpase or kinase
Slip_0559	COG1214	PFAM Peptidase M22, glycoprotease
Slip_0560	COG0456	acetyltransferase
Slip_0561	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Slip_0563	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Slip_0564	COG1408	metallophosphoesterase
Slip_0567	COG1910	domain protein
Slip_0568	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Slip_0569	COG0315	cyclic pyranopterin monophosphate synthase activity
Slip_0571	COG0521	Mo-molybdopterin cofactor biosynthetic process
Slip_0571	COG0315	cyclic pyranopterin monophosphate synthase activity
Slip_0572	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Slip_0573	COG0459	protein refolding
Slip_0576	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Slip_0579	COG1250	3-hydroxyacyl-CoA dehydrogenase
Slip_0580	COG1024	Enoyl-CoA hydratase
Slip_0581	COG1960	acyl-CoA dehydrogenase activity
Slip_0583	COG0318	PFAM AMP-dependent synthetase and ligase
Slip_0585	COG3604	Transcriptional regulator
Slip_0587	COG0840	transmembrane signaling receptor activity
Slip_0590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Slip_0590	COG0519	Catalyzes the synthesis of GMP from XMP
Slip_0591	COG1199	ATP-dependent helicase activity
Slip_0596	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Slip_0597	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Slip_0598	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Slip_0599	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Slip_0600	COG0047	phosphoribosylformylglycinamidine synthase activity
Slip_0601	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Slip_0602	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Slip_0603	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Slip_0604	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Slip_0605	COG0138	bifunctional purine biosynthesis protein purh
Slip_0606	COG0151	Belongs to the GarS family
Slip_0609	COG4496	protein, YerC YecD
Slip_0610	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Slip_0611	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Slip_0613	COG0131	Imidazoleglycerol-phosphate dehydratase
Slip_0614	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Slip_0615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Slip_0616	COG0107	imidazoleglycerol-phosphate synthase activity
Slip_0617	COG0140	phosphoribosyl-ATP diphosphatase activity
Slip_0617	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Slip_0618	COG0210	DNA helicase
Slip_0619	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Slip_0628	COG1242	4 iron, 4 sulfur cluster binding
Slip_0632	COG0297	glycogen (starch) synthase activity
Slip_0633	COG1732	Glycine betaine
Slip_0634	COG1174	glycine betaine transport
Slip_0635	COG1174	glycine betaine transport
Slip_0636	COG0517	IMP dehydrogenase activity
Slip_0636	COG1125	glycine betaine transport
Slip_0641	COG2843	Capsule synthesis protein
Slip_0643	COG0579	oxidoreductase
Slip_0646	COG1543	Belongs to the glycosyl hydrolase 57 family
Slip_0653	COG0328	RNA-DNA hybrid ribonuclease activity
Slip_0657	COG3260	NADH ubiquinone oxidoreductase 20
Slip_0659	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Slip_0659	COG3261	NADH dehydrogenase
Slip_0665	COG0427	acetyl-CoA hydrolase
Slip_0667	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Slip_0669	COG0559	Belongs to the binding-protein-dependent transport system permease family
Slip_0671	COG0411	ABC transporter
Slip_0673	COG2385	sporulation resulting in formation of a cellular spore
Slip_0675	COG2221	Nitrite and sulphite reductase 4Fe-4S
Slip_0678	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Slip_0680	COG0525	valine-tRNA ligase activity
Slip_0681	COG0285	dihydrofolate synthase activity
Slip_0683	COG0306	phosphate transporter
Slip_0684	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Slip_0686	COG0424	maF-like protein
Slip_0687	COG2003	Belongs to the UPF0758 family
Slip_0688	COG1077	Cell shape determining protein MreB Mrl
Slip_0695	COG2894	cell division
Slip_0696	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Slip_0697	COG0772	Belongs to the SEDS family
Slip_0698	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Slip_0704	COG1530	ribonuclease E activity
Slip_0705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Slip_0707	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Slip_0709	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Slip_0710	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Slip_0711	COG2414	aldehyde ferredoxin oxidoreductase
Slip_0713	COG0653	protein targeting
Slip_0718	COG3118	belongs to the thioredoxin family
Slip_0720	COG0194	GDP metabolic process
Slip_0721	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Slip_0722	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Slip_0724	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Slip_0724	COG2199	diguanylate cyclase activity
Slip_0728	COG1131	(ABC) transporter
Slip_0729	COG1131	(ABC) transporter
Slip_0730	COG0842	Transport permease protein
Slip_0731	COG1309	transcriptional regulator
Slip_0733	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Slip_0734	COG1410	methionine synthase
Slip_0734	COG0646	methionine synthase
Slip_0738	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Slip_0739	COG0217	transcriptional regulatory protein
Slip_0741	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Slip_0742	COG0632	four-way junction helicase activity
Slip_0743	COG2255	four-way junction helicase activity
Slip_0744	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Slip_0748	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Slip_0749	COG0343	queuine tRNA-ribosyltransferase activity
Slip_0752	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Slip_0753	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Slip_0757	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Slip_0759	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Slip_0759	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Slip_0762	COG0438	transferase activity, transferring glycosyl groups
Slip_0763	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Slip_0766	COG1230	cation diffusion facilitator family transporter
Slip_0767	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Slip_0767	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Slip_0768	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Slip_0769	COG1490	D-aminoacyl-tRNA deacylase activity
Slip_0770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Slip_0771	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Slip_0772	COG1605	Chorismate mutase
Slip_0772	COG0077	Prephenate dehydratase
Slip_0773	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Slip_0774	COG0124	histidyl-tRNA synthetase
Slip_0775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Slip_0776	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Slip_0778	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Slip_0782	COG1830	Aldolase
Slip_0783	COG1063	alcohol dehydrogenase
Slip_0786	COG2001	Belongs to the MraZ family
Slip_0787	COG0275	rRNA processing
Slip_0789	COG0768	penicillin binding
Slip_0790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Slip_0791	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Slip_0792	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Slip_0793	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Slip_0794	COG0772	Belongs to the SEDS family
Slip_0795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Slip_0796	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Slip_0797	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Slip_0798	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Slip_0799	COG0640	Transcriptional regulator
Slip_0801	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Slip_0803	COG3856	small basic protein
Slip_0805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Slip_0807	COG1191	sigma factor activity
Slip_0808	COG1191	sigma factor activity
Slip_0810	COG1873	PFAM PRC-barrel domain
Slip_0811	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Slip_0813	COG0602	queuosine metabolic process
Slip_0815	COG0745	RESPONSE REGULATOR receiver
Slip_0816	COG5002	protein histidine kinase activity
Slip_0818	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Slip_0819	COG1799	cell septum assembly
Slip_0820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Slip_0822	COG0826	peptidase U32
Slip_0823	COG3599	regulation of cell shape
Slip_0824	COG1872	DUF167
Slip_0825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Slip_0827	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Slip_0828	COG3830	Belongs to the UPF0237 family
Slip_0829	COG2848	UPF0210 protein
Slip_0830	COG0778	Nitroreductase
Slip_0833	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Slip_0834	COG0438	transferase activity, transferring glycosyl groups
Slip_0835	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Slip_0836	COG0564	pseudouridine synthase activity
Slip_0837	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Slip_0838	COG0540	Belongs to the ATCase OTCase family
Slip_0839	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Slip_0840	COG0543	2 iron, 2 sulfur cluster binding
Slip_0841	COG0167	dihydroorotate dehydrogenase activity
Slip_0842	COG0284	orotidine-5'-phosphate decarboxylase activity
Slip_0843	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Slip_0849	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Slip_0850	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Slip_0851	COG0436	Aminotransferase
Slip_0852	COG1561	YicC-like family, N-terminal region
Slip_0853	COG2052	Domain of unknown function (DUF370)
Slip_0854	COG0194	GDP metabolic process
Slip_0855	COG1758	RNA polymerase activity
Slip_0856	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Slip_0857	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Slip_0858	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Slip_0859	COG0242	peptide deformylase activity
Slip_0860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Slip_0862	COG2738	Putative neutral zinc metallopeptidase
Slip_0863	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Slip_0863	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Slip_0864	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Slip_0865	COG0631	protein serine/threonine phosphatase activity
Slip_0866	COG0515	serine threonine protein kinase
Slip_0866	COG2815	serine threonine protein kinase
Slip_0867	COG1162	GTPase activity
Slip_0868	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Slip_0871	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Slip_0871	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Slip_0872	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Slip_0873	COG1846	Transcriptional regulator
Slip_0874	COG1960	acyl-CoA dehydrogenase activity
Slip_0877	COG0644	oxidoreductase
Slip_0878	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
Slip_0879	COG3290	protein histidine kinase activity
Slip_0879	COG3829	transcription factor binding
Slip_0880	COG0183	Belongs to the thiolase family
Slip_0881	COG1960	acyl-CoA dehydrogenase activity
Slip_0882	COG0427	acetyl-CoA hydrolase
Slip_0883	COG3829	transcription factor binding
Slip_0883	COG3290	protein histidine kinase activity
Slip_0884	COG1960	acyl-CoA dehydrogenase activity
Slip_0885	COG3706	GGDEF domain
Slip_0885	COG0745	RESPONSE REGULATOR receiver
Slip_0888	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Slip_0889	COG1302	Protein conserved in bacteria
Slip_0890	COG1461	Dihydroxyacetone kinase
Slip_0891	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Slip_0894	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Slip_0895	COG0742	ribosomal rna small subunit methyltransferase
Slip_0897	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Slip_0898	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Slip_0900	COG1752	Esterase of the alpha-beta hydrolase superfamily
Slip_0901	COG1323	Belongs to the UPF0348 family
Slip_0902	COG0280	phosphate acetyltransferase
Slip_0903	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Slip_0905	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Slip_0906	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Slip_0907	COG0228	four-way junction DNA binding
Slip_0908	COG1837	Belongs to the UPF0109 family
Slip_0909	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Slip_0910	COG0336	Belongs to the RNA methyltransferase TrmD family
Slip_0911	COG4752	Belongs to the RNA methyltransferase TrmD family
Slip_0912	COG0335	large ribosomal subunit rRNA binding
Slip_0913	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Slip_0914	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Slip_0916	COG2257	FlhB HrpN YscU SpaS Family
Slip_0917	COG0792	nuclease activity
Slip_0918	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Slip_0923	COG2875	Belongs to the precorrin methyltransferase family
Slip_0929	COG1122	ATPase activity
Slip_0931	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
Slip_0932	COG0310	cobalt ion transport
Slip_0934	COG1797	cobyrinic acid a,c-diamide synthase activity
Slip_0935	COG1959	2 iron, 2 sulfur cluster binding
Slip_0936	COG1151	hydroxylamine reductase activity
Slip_0938	COG0606	chelatase, subunit chli
Slip_0941	COG0432	Pfam Uncharacterised protein family UPF0047
Slip_0943	COG0758	DNA mediated transformation
Slip_0943	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Slip_0944	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Slip_0945	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Slip_0946	COG4974	Belongs to the 'phage' integrase family
Slip_0947	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Slip_0948	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Slip_0950	COG1815	bacterial-type flagellum-dependent cell motility
Slip_0951	COG1558	bacterial-type flagellum-dependent cell motility
Slip_0953	COG1766	The M ring may be actively involved in energy transduction
Slip_0954	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Slip_0955	COG1317	bacterial-type flagellum organization
Slip_0956	COG1157	protein secretion by the type III secretion system
Slip_0960	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Slip_0963	COG1582	Flagellar protein (FlbD)
Slip_0965	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Slip_0966	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Slip_0966	COG1776	CheC inhibitor of MCP methylation
Slip_0967	COG2201	protein-glutamate methylesterase activity
Slip_0969	COG1338	Plays a role in the flagellum-specific transport system
Slip_0970	COG1987	bacterial-type flagellum assembly
Slip_0971	COG1684	flagellar biosynthetic protein fliR
Slip_0972	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Slip_0973	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Slip_0974	COG1419	protein localization to endoplasmic reticulum
Slip_0975	COG0455	bacterial-type flagellum organization
Slip_0977	COG2201	protein-glutamate methylesterase activity
Slip_0978	COG2198	Histidine kinase
Slip_0978	COG0643	Histidine kinase
Slip_0979	COG0835	chemotaxis
Slip_0980	COG1776	CheC inhibitor of MCP methylation
Slip_0981	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Slip_0982	COG1191	sigma factor activity
Slip_0986	COG0052	Belongs to the universal ribosomal protein uS2 family
Slip_0987	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Slip_0988	COG0528	UMP kinase activity
Slip_0989	COG0233	cytoplasmic translational termination
Slip_0992	COG0628	permease
Slip_0993	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Slip_0994	COG0750	zinc metalloprotease
Slip_0995	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Slip_0996	COG0442	prolyl-tRNA aminoacylation
Slip_0997	COG1285	pathogenesis
Slip_0998	COG2176	DNA-directed DNA polymerase activity
Slip_0999	COG0779	Required for maturation of 30S ribosomal subunits
Slip_1000	COG0195	Participates in both transcription termination and antitermination
Slip_1003	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Slip_1004	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Slip_1006	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Slip_1007	COG0196	riboflavin kinase activity
Slip_1008	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Slip_1009	COG1185	polyribonucleotide nucleotidyltransferase activity
Slip_1010	COG2720	vancomycin resistance protein
Slip_1011	COG0726	polysaccharide deacetylase
Slip_1012	COG1686	Belongs to the peptidase S11 family
Slip_1013	COG0612	Peptidase, M16
Slip_1016	COG1873	PFAM PRC-barrel domain
Slip_1019	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Slip_1022	COG1116	anion transmembrane transporter activity
Slip_1022	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Slip_1023	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Slip_1024	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Slip_1025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Slip_1026	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Slip_1027	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Slip_1028	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Slip_1029	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Slip_1029	COG0517	IMP dehydrogenase activity
Slip_1030	COG2814	Major facilitator Superfamily
Slip_1032	COG3383	formate dehydrogenase (NAD+) activity
Slip_1033	COG0740	serine-type endopeptidase activity
Slip_1035	COG0840	transmembrane signaling receptor activity
Slip_1037	COG1968	undecaprenyl-diphosphatase activity
Slip_1038	COG1674	ftsk spoiiie
Slip_1039	COG1522	sequence-specific DNA binding
Slip_1039	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Slip_1040	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Slip_1042	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Slip_1043	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Slip_1045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Slip_1048	COG1546	Belongs to the CinA family
Slip_1048	COG1058	Belongs to the CinA family
Slip_1049	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Slip_1050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Slip_1051	COG1418	mRNA catabolic process
Slip_1052	COG1692	metallophosphoesterase
Slip_1053	COG2359	stage V sporulation protein S
Slip_1055	COG0613	PHP domain protein
Slip_1056	COG0840	transmembrane signaling receptor activity
Slip_1057	COG1388	LysM domain
Slip_1057	COG0791	NLP P60 protein
Slip_1059	COG0516	GMP reductase activity
Slip_1059	COG0517	IMP dehydrogenase activity
Slip_1060	COG0824	Thioesterase
Slip_1061	COG1285	pathogenesis
Slip_1062	COG0697	spore germination
Slip_1069	COG1307	EDD domain protein, DegV family
Slip_1071	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Slip_1073	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Slip_1074	COG0145	ligase activity
Slip_1076	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Slip_1077	COG2136	Putative SAM-dependent methyltransferase
Slip_1077	COG2521	methyltransferase
Slip_1078	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Slip_1079	COG1923	regulation of RNA biosynthetic process
Slip_1080	COG0464	growth
Slip_1081	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Slip_1083	COG0174	glutamine synthetase
Slip_1084	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Slip_1086	COG0247	lactate metabolic process
Slip_1087	COG0277	FAD linked oxidase domain protein
Slip_1088	COG3875	lactate racemase activity
Slip_1089	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Slip_1090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Slip_1093	COG1032	radical SAM domain protein
Slip_1095	COG0688	phosphatidylethanolamine metabolic process
Slip_1096	COG1183	phosphatidylcholine synthase activity
Slip_1100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Slip_1104	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Slip_1106	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Slip_1106	COG4651	solute:proton antiporter activity
Slip_1107	COG2199	diguanylate cyclase activity
Slip_1112	COG0012	GTP binding
Slip_1119	COG5002	protein histidine kinase activity
Slip_1121	COG1683	Conserved Protein
Slip_1123	COG1307	EDD domain protein, DegV family
Slip_1125	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Slip_1126	COG0732	type I restriction modification DNA specificity domain
Slip_1127	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Slip_1128	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Slip_1131	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Slip_1151	COG3328	transposase activity
Slip_1159	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Slip_1160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Slip_1163	COG1615	UPF0182 protein
Slip_1164	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Slip_1165	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Slip_1166	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Slip_1167	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Slip_1170	COG1181	Belongs to the D-alanine--D-alanine ligase family
Slip_1171	COG0613	PHP domain protein
Slip_1172	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Slip_1173	COG4120	Belongs to the binding-protein-dependent transport system permease family
Slip_1185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Slip_1186	COG4969	Belongs to the N-Me-Phe pilin family
Slip_1195	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Slip_1198	COG2048	Heterodisulfide reductase, subunit B
Slip_1200	COG0446	pyridine nucleotide-disulphide oxidoreductase
Slip_1200	COG1902	pentaerythritol trinitrate reductase activity
Slip_1203	COG3829	transcription factor binding
Slip_1203	COG3290	protein histidine kinase activity
Slip_1206	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Slip_1208	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Slip_1211	COG0302	gtp cyclohydrolase
Slip_1212	COG0602	queuosine metabolic process
Slip_1214	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Slip_1215	COG0720	synthase
Slip_1217	COG0428	transporter
Slip_1219	COG0730	response to heat
Slip_1225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Slip_1228	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Slip_1233	COG3290	protein histidine kinase activity
Slip_1233	COG3829	transcription factor binding
Slip_1234	COG1024	Enoyl-CoA hydratase
Slip_1236	COG0183	Belongs to the thiolase family
Slip_1238	COG1250	3-hydroxyacyl-CoA dehydrogenase
Slip_1239	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Slip_1241	COG1960	acyl-CoA dehydrogenase activity
Slip_1242	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Slip_1243	COG3829	transcription factor binding
Slip_1243	COG3290	protein histidine kinase activity
Slip_1250	COG0840	transmembrane signaling receptor activity
Slip_1251	COG5001	Diguanylate cyclase
Slip_1251	COG3300	MHYT domain
Slip_1261	COG2197	response regulator
Slip_1281	COG0402	S-adenosylhomocysteine deaminase activity
Slip_1283	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Slip_1284	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Slip_1285	COG0552	protein localization to endoplasmic reticulum
Slip_1286	COG1196	nuclear chromosome segregation
Slip_1289	COG0571	ribonuclease III activity
Slip_1290	COG0416	fatty acid biosynthetic process
Slip_1291	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Slip_1297	COG1131	(ABC) transporter
Slip_1298	COG1725	Transcriptional regulator
Slip_1311	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Slip_1313	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Slip_1314	COG1322	Protein conserved in bacteria
Slip_1320	COG0631	protein serine/threonine phosphatase activity
Slip_1326	COG1116	anion transmembrane transporter activity
Slip_1328	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Slip_1331	COG0142	geranyltranstransferase activity
Slip_1343	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Slip_1344	COG1518	maintenance of DNA repeat elements
Slip_1346	COG1203	CRISPR-associated helicase, Cas3
Slip_1361	COG0517	IMP dehydrogenase activity
Slip_1361	COG0516	GMP reductase activity
Slip_1362	COG0398	Pfam SNARE associated Golgi protein
Slip_1365	COG3290	protein histidine kinase activity
Slip_1365	COG0840	transmembrane signaling receptor activity
Slip_1370	COG1067	ATP-dependent peptidase activity
Slip_1372	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Slip_1373	COG0598	Magnesium transport protein CorA
Slip_1380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Slip_1383	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Slip_1388	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Slip_1390	COG0436	Aminotransferase
Slip_1391	COG1522	sequence-specific DNA binding
Slip_1392	COG0446	pyridine nucleotide-disulphide oxidoreductase
Slip_1396	COG1686	Belongs to the peptidase S11 family
Slip_1397	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Slip_1398	COG1051	belongs to the nudix hydrolase family
Slip_1401	COG1307	EDD domain protein, DegV family
Slip_1404	COG2442	InterPro IPR007367
Slip_1413	COG1388	LysM domain
Slip_1413	COG3584	3D domain protein
Slip_1414	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Slip_1415	COG1250	3-hydroxyacyl-CoA dehydrogenase
Slip_1416	COG0247	lactate metabolic process
Slip_1416	COG2181	nitrate reductase activity
Slip_1417	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Slip_1418	COG2086	electron transfer activity
Slip_1419	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Slip_1420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Slip_1423	COG0535	radical SAM domain protein
Slip_1424	COG0113	porphobilinogen synthase activity
Slip_1425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Slip_1427	COG0181	hydroxymethylbilane synthase activity
Slip_1428	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Slip_1429	COG1648	precorrin-2 dehydrogenase activity
Slip_1429	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Slip_1430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Slip_1432	COG2864	formate dehydrogenase
Slip_1433	COG0437	4 iron, 4 sulfur cluster binding
Slip_1435	COG0805	protein transport
Slip_1439	COG0109	protoheme IX farnesyltransferase activity
Slip_1440	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Slip_1442	COG0825	malonyl-CoA metabolic process
Slip_1443	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Slip_1444	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Slip_1445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Slip_1446	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Slip_1447	COG1028	Short-chain dehydrogenase reductase Sdr
Slip_1448	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Slip_1450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Slip_1451	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Slip_1453	COG0406	alpha-ribazole phosphatase activity
Slip_1458	COG1120	ATPase activity
Slip_1459	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Slip_1460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Slip_1463	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Slip_1464	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Slip_1465	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Slip_1468	COG0460	homoserine dehydrogenase
Slip_1470	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Slip_1471	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Slip_1472	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Slip_1473	COG1160	GTP binding
Slip_1479	COG2333	competence protein COMEC
Slip_1479	COG0658	competence protein
Slip_1481	COG1304	FMN binding
Slip_1482	COG0746	molybdenum cofactor guanylyltransferase activity
Slip_1484	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Slip_1484	COG0539	negative regulation of cytoplasmic translation
Slip_1485	COG0204	Acyl-transferase
Slip_1486	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Slip_1489	COG3290	protein histidine kinase activity
Slip_1490	COG0072	phenylalanine-tRNA ligase activity
Slip_1490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Slip_1490	COG0072	phenylalanine-tRNA ligase activity
Slip_1490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Slip_1491	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Slip_1492	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Slip_1493	COG0569	domain protein
Slip_1494	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Slip_1495	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Slip_1496	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Slip_1498	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Slip_1502	COG0726	polysaccharide deacetylase
Slip_1504	COG1131	(ABC) transporter
Slip_1506	COG1215	transferase activity, transferring glycosyl groups
Slip_1508	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Slip_1509	COG1793	dna ligase
Slip_1510	COG1793	dna ligase
Slip_1510	COG3285	dna ligase
Slip_1512	COG0726	polysaccharide deacetylase
Slip_1513	COG0726	polysaccharide deacetylase
Slip_1517	COG1253	flavin adenine dinucleotide binding
Slip_1521	COG3409	Peptidoglycan-binding domain 1 protein
Slip_1521	COG0860	N-Acetylmuramoyl-L-alanine amidase
Slip_1522	COG0432	Pfam Uncharacterised protein family UPF0047
Slip_1523	COG3359	exonuclease
Slip_1524	COG1111	helicase
Slip_1524	COG1205	dead DEAH box helicase
Slip_1527	COG1136	(ABC) transporter
Slip_1530	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Slip_1534	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Slip_1534	COG4624	Iron only hydrogenase large subunit, C-terminal domain
Slip_1535	COG0728	peptidoglycan biosynthetic process
Slip_1536	COG0426	domain, Protein
Slip_1537	COG2033	superoxide reductase activity
Slip_1543	COG1518	maintenance of DNA repeat elements
Slip_1548	COG1203	CRISPR-associated helicase, Cas3
Slip_1551	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Slip_1553	COG0583	DNA-binding transcription factor activity
Slip_1554	COG0719	Fe-S assembly protein
Slip_1555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Slip_1557	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Slip_1558	COG0735	belongs to the Fur family
Slip_1559	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Slip_1564	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Slip_1564	COG0493	'glutamate synthase
Slip_1565	COG0069	glutamate synthase activity
Slip_1566	COG0067	glutamate synthase
Slip_1567	COG0174	glutamine synthetase
Slip_1570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Slip_1570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Slip_1571	COG0004	ammonium transporteR
Slip_1572	COG0347	Belongs to the P(II) protein family
Slip_1573	COG0367	asparagine synthase
Slip_1574	COG1160	GTP binding
Slip_1575	COG1027	Aspartate ammonia-lyase
Slip_1577	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Slip_1581	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Slip_1584	COG1763	Mo-molybdopterin cofactor biosynthetic process
Slip_1591	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Slip_1608	COG3409	Peptidoglycan-binding domain 1 protein
Slip_1608	COG3267	Type II secretory pathway component ExeA
Slip_1620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Slip_1621	COG0358	DNA primase activity
Slip_1625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Slip_1625	COG0574	Belongs to the PEP-utilizing enzyme family
Slip_1626	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Slip_1627	COG0517	IMP dehydrogenase activity
Slip_1628	COG0751	glycine-tRNA ligase activity
Slip_1629	COG0752	glycyl-tRNA synthetase alpha subunit
Slip_1634	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Slip_1635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Slip_1636	COG0295	cytidine deaminase activity
Slip_1637	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Slip_1638	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Slip_1639	COG1480	7TM receptor with intracellular HD hydrolase
Slip_1640	COG1702	phosphate starvation-inducible protein PhoH
Slip_1645	COG0537	adenosine 5'-monophosphoramidase activity
Slip_1647	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Slip_1648	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Slip_1649	COG2264	protein methyltransferase activity
Slip_1651	COG0443	Heat shock 70 kDa protein
Slip_1652	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Slip_1653	COG1420	regulation of RNA biosynthetic process
Slip_1654	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Slip_1655	COG0481	GTPase activity
Slip_1659	COG0268	Binds directly to 16S ribosomal RNA
Slip_1661	COG1606	tRNA processing
Slip_1662	COG2217	Heavy metal translocating P-type atpase
Slip_1663	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Slip_1665	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Slip_1666	COG2333	competence protein COMEC
Slip_1666	COG0658	competence protein
Slip_1667	COG1596	polysaccharide export
Slip_1667	COG1555	photosystem II stabilization
Slip_1669	COG0495	leucyl-tRNA aminoacylation
Slip_1670	COG2508	Transcriptional regulator
Slip_1672	COG1053	succinate dehydrogenase
Slip_1676	COG1333	cytochrome c biogenesis protein
Slip_1677	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Slip_1678	COG5632	N-Acetylmuramoyl-L-alanine amidase
Slip_1678	COG3409	Peptidoglycan-binding domain 1 protein
Slip_1679	COG0799	negative regulation of ribosome biogenesis
Slip_1680	COG1713	HD superfamily hydrolase involved in NAD metabolism
Slip_1681	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Slip_1683	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Slip_1685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Slip_1686	COG0318	PFAM AMP-dependent synthetase and ligase
Slip_1687	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Slip_1690	COG0747	negative chemotaxis
Slip_1691	COG0739	heme binding
Slip_1691	COG0741	lytic transglycosylase activity
Slip_1691	COG1196	nuclear chromosome segregation
Slip_1692	COG0237	dephospho-CoA kinase activity
Slip_1693	COG1971	Probably functions as a manganese efflux pump
Slip_1694	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Slip_1696	COG1381	Involved in DNA repair and RecF pathway recombination
Slip_1702	COG0205	6-phosphofructokinase activity
Slip_1713	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Slip_1714	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Slip_1716	COG0494	nUDIX hydrolase
Slip_1717	COG1193	negative regulation of DNA recombination
Slip_1723	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Slip_1723	COG1796	DNA polymerase
Slip_1724	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Slip_1726	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Slip_1728	COG2198	Histidine kinase
Slip_1728	COG0643	Histidine kinase
Slip_1729	COG1192	Involved in chromosome partitioning
Slip_1731	COG0443	Heat shock 70 kDa protein
Slip_1732	COG3290	protein histidine kinase activity
Slip_1732	COG0840	transmembrane signaling receptor activity
Slip_1733	COG0835	chemotaxis
Slip_1734	COG2201	protein-glutamate methylesterase activity
Slip_1735	COG2201	protein-glutamate methylesterase activity
Slip_1737	COG1406	Chemotaxis phosphatase CheX
Slip_1739	COG0840	transmembrane signaling receptor activity
Slip_1739	COG3290	protein histidine kinase activity
Slip_1740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Slip_1741	COG0287	Prephenate dehydrogenase
Slip_1742	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Slip_1744	COG0735	belongs to the Fur family
Slip_1746	COG1121	(ABC) transporter
Slip_1747	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Slip_1748	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Slip_1749	COG0159	tryptophan synthase activity
Slip_1750	COG0133	tryptophan synthase activity
Slip_1751	COG0134	indole-3-glycerol-phosphate synthase activity
Slip_1752	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Slip_1755	COG1725	Transcriptional regulator
Slip_1756	COG1131	(ABC) transporter
Slip_1765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Slip_1769	COG1691	(AIR) carboxylase
Slip_1775	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Slip_1776	COG1639	'signal transduction protein
Slip_1778	COG1187	pseudouridine synthase activity
Slip_1780	COG1228	amidohydrolase
Slip_1781	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Slip_1782	COG2337	Toxic component of a toxin-antitoxin (TA) module
Slip_1783	COG0864	Transcriptional regulator
Slip_1784	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Slip_1785	COG0516	GMP reductase activity
Slip_1785	COG0517	IMP dehydrogenase activity
Slip_1786	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Slip_1786	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Slip_1787	COG0736	holo-[acyl-carrier-protein] synthase activity
Slip_1789	COG0835	chemotaxis
Slip_1790	COG0604	alcohol dehydrogenase
Slip_1792	COG0840	transmembrane signaling receptor activity
Slip_1795	COG2856	Zn peptidase
Slip_1810	COG0741	lytic transglycosylase activity
Slip_1820	COG1484	DNA-dependent DNA replication
Slip_1836	COG1396	sequence-specific DNA binding
Slip_1841	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Slip_1842	COG0557	exoribonuclease II activity
Slip_1845	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Slip_1846	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Slip_1847	COG0148	phosphopyruvate hydratase activity
Slip_1849	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Slip_1850	COG0149	triose-phosphate isomerase activity
Slip_1851	COG0126	phosphoglycerate kinase activity
Slip_1854	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Slip_1855	COG1481	regulation of sporulation
Slip_1856	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Slip_1857	COG1660	Displays ATPase and GTPase activities
Slip_1858	COG2222	sugar isomerase
Slip_1859	COG1940	carbohydrate kinase activity
Slip_1861	COG0561	phosphatase activity
Slip_1863	COG0322	excinuclease ABC activity
Slip_1865	COG0556	nucleotide-excision repair
Slip_1867	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Slip_1868	COG0793	Belongs to the peptidase S41A family
Slip_1870	COG0739	heme binding
Slip_1870	COG0741	lytic transglycosylase activity
Slip_1870	COG1196	nuclear chromosome segregation
Slip_1871	COG2177	Part of the ABC transporter FtsEX involved in
Slip_1872	COG2884	Cell division ATP-binding protein ftsE
Slip_1873	COG3958	Transketolase
Slip_1874	COG3959	Transketolase, thiamine diphosphate binding domain
Slip_1877	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Slip_1878	COG0653	protein targeting
Slip_1882	COG1516	flagellar protein fliS
Slip_1886	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
Slip_1898	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Slip_1904	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Slip_1905	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Slip_1906	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Slip_1910	COG4786	Flagellar basal body rod
Slip_1910	COG1256	bacterial-type flagellum assembly
Slip_1914	COG1040	competence protein
Slip_1927	COG2197	response regulator
Slip_1929	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Slip_1945	COG0270	DNA (cytosine-5-)-methyltransferase activity
Slip_1947	COG1194	a g-specific adenine glycosylase
Slip_1949	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Slip_1950	COG2323	membrane
Slip_1951	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Slip_1953	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Slip_1955	COG1309	transcriptional regulator
Slip_1957	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Slip_1968	COG1598	PFAM Uncharacterised protein family UPF0150
Slip_1975	COG0582	viral genome integration into host DNA
Slip_1976	COG1192	Involved in chromosome partitioning
Slip_1981	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Slip_1982	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Slip_1983	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Slip_1985	COG0183	Belongs to the thiolase family
Slip_1988	COG0183	Belongs to the thiolase family
Slip_1989	COG1024	Enoyl-CoA hydratase
Slip_1990	COG3290	protein histidine kinase activity
Slip_1990	COG3829	transcription factor binding
Slip_1997	COG1309	transcriptional regulator
Slip_2001	COG0784	Response regulator, receiver
Slip_2001	COG3437	response regulator, receiver
Slip_2010	COG2003	Belongs to the UPF0758 family
Slip_2021	COG0464	growth
Slip_2023	COG1988	membrane-bound metal-dependent
Slip_2046	COG4974	Belongs to the 'phage' integrase family
Slip_2049	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Slip_2050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Slip_2053	COG1234	tRNA 3'-trailer cleavage
Slip_2055	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Slip_2056	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Slip_2061	COG3279	Response regulator of the LytR AlgR family
Slip_2063	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Slip_2064	COG0446	pyridine nucleotide-disulphide oxidoreductase
Slip_2064	COG1902	pentaerythritol trinitrate reductase activity
Slip_2076	COG0493	'glutamate synthase
Slip_2077	COG0543	2 iron, 2 sulfur cluster binding
Slip_2078	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Slip_2082	COG0477	Major facilitator Superfamily
Slip_2083	COG1960	acyl-CoA dehydrogenase activity
Slip_2085	COG0183	Belongs to the thiolase family
Slip_2087	COG1028	Short-chain dehydrogenase reductase Sdr
Slip_2088	COG1250	3-hydroxyacyl-CoA dehydrogenase
Slip_2089	COG1024	Enoyl-CoA hydratase
Slip_2090	COG2030	dehydratase
Slip_2091	COG0589	response to stress
Slip_2092	COG0840	transmembrane signaling receptor activity
Slip_2097	COG1034	ATP synthesis coupled electron transport
Slip_2101	COG2414	aldehyde ferredoxin oxidoreductase
Slip_2102	COG0437	4 iron, 4 sulfur cluster binding
Slip_2103	COG0493	'glutamate synthase
Slip_2105	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Slip_2106	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Slip_2109	COG1960	acyl-CoA dehydrogenase activity
Slip_2110	COG2086	electron transfer activity
Slip_2111	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Slip_2116	COG0653	protein targeting
Slip_2118	COG0347	Belongs to the P(II) protein family
Slip_2119	COG0004	ammonium transporteR
Slip_2120	COG0505	Belongs to the CarA family
Slip_2121	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Slip_2122	COG4149	molybdate abc transporter
Slip_2124	COG1433	Dinitrogenase iron-molybdenum cofactor
Slip_2124	COG0535	radical SAM domain protein
Slip_2128	COG0347	Belongs to the P(II) protein family
Slip_2129	COG0347	Belongs to the P(II) protein family
Slip_2132	COG2200	EAL domain
Slip_2136	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Slip_2137	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Slip_2139	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Slip_2140	COG1801	Protein of unknown function DUF72
Slip_2141	COG0587	DNA-directed DNA polymerase activity
Slip_2143	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Slip_2155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Slip_2156	COG0473	3-isopropylmalate dehydrogenase activity
Slip_2157	COG0066	3-isopropylmalate dehydratase activity
Slip_2158	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Slip_2159	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Slip_2160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Slip_2162	COG0028	Belongs to the TPP enzyme family
Slip_2163	COG0129	dihydroxy-acid dehydratase activity
Slip_2164	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Slip_2171	COG0165	Argininosuccinate lyase
Slip_2172	COG0137	argininosuccinate synthase activity
Slip_2174	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Slip_2175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Slip_2176	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Slip_2177	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Slip_2178	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Slip_2179	COG2226	methyltransferase
Slip_2182	COG0095	Lipoate-protein ligase
Slip_2183	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Slip_2184	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Slip_2189	COG0798	PFAM Bile acid sodium symporter
Slip_2191	COG0730	response to heat
Slip_2197	COG1024	Enoyl-CoA hydratase
Slip_2200	COG0860	N-Acetylmuramoyl-L-alanine amidase
Slip_2200	COG2247	cell wall binding repeat
Slip_2201	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Slip_2202	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Slip_2203	COG0101	tRNA pseudouridine synthase activity
Slip_2204	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Slip_2205	COG1122	ATPase activity
Slip_2206	COG1122	ATPase activity
Slip_2207	COG0203	ribosomal protein L17
Slip_2208	COG0202	RNA polymerase activity
Slip_2209	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Slip_2210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Slip_2211	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Slip_2212	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Slip_2213	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Slip_2215	COG0024	Methionine aminopeptidase
Slip_2216	COG0563	adenylate kinase activity
Slip_2217	COG0201	protein transport
Slip_2218	COG0200	Binds to the 23S rRNA
Slip_2219	COG1841	ribosomal large subunit assembly
Slip_2220	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Slip_2221	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Slip_2222	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Slip_2223	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Slip_2224	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Slip_2225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Slip_2226	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Slip_2227	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Slip_2228	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Slip_2229	COG0255	Belongs to the universal ribosomal protein uL29 family
Slip_2230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Slip_2231	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Slip_2232	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Slip_2233	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Slip_2234	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Slip_2235	COG0089	rRNA binding
Slip_2236	COG0088	Forms part of the polypeptide exit tunnel
Slip_2237	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Slip_2238	COG0051	transcription antitermination factor activity, RNA binding
Slip_2239	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Slip_2240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Slip_2241	COG0049	tRNA binding
Slip_2242	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Slip_2243	COG1358	cellular component organization or biogenesis
Slip_2244	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Slip_2245	COG0085	RNA polymerase activity
Slip_2247	COG0222	ribosome binding
Slip_2248	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Slip_2249	COG0081	regulation of translation
Slip_2250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Slip_2251	COG0250	Participates in transcription elongation, termination and antitermination
Slip_2253	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Slip_2255	COG3688	RNA-binding protein containing a PIN domain
Slip_2256	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Slip_2259	COG0215	cysteine-tRNA ligase activity
Slip_2260	COG1045	serine acetyltransferase
Slip_2261	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Slip_2262	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Slip_2263	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Slip_2264	COG4956	integral membrane protein (PIN domain superfamily)
Slip_2266	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Slip_2267	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Slip_2268	COG0542	response to heat
Slip_2269	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Slip_2270	COG3880	PFAM UvrB UvrC protein
Slip_2274	COG4786	Flagellar basal body rod
Slip_2275	COG1077	Cell shape determining protein MreB Mrl
Slip_2276	COG1609	Transcriptional regulator
Slip_2277	COG2385	sporulation resulting in formation of a cellular spore
Slip_2278	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Slip_2281	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Slip_2282	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Slip_2283	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Slip_2284	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Slip_2285	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Slip_2286	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Slip_2287	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Slip_2288	COG0356	it plays a direct role in the translocation of protons across the membrane
Slip_2292	COG0590	tRNA wobble adenosine to inosine editing
Slip_2293	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Slip_2294	COG0698	ribose 5-phosphate isomerase
Slip_2296	COG1971	Probably functions as a manganese efflux pump
Slip_2297	COG0009	L-threonylcarbamoyladenylate synthase
Slip_2298	COG2890	protein-(glutamine-N5) methyltransferase activity
Slip_2299	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Slip_2300	COG3872	metal-dependent enzyme
Slip_2301	COG0254	rRNA binding
Slip_2303	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Slip_2305	COG0739	heme binding
Slip_2306	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Slip_2308	COG1494	fructose-1,6-bisphosphatase
Slip_2309	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Slip_2311	COG2204	response regulator
Slip_2313	COG0616	signal peptide processing
Slip_2314	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Slip_2316	COG0504	CTP synthase activity
Slip_2317	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Slip_2319	COG0018	arginyl-trna synthetase
Slip_2327	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Slip_2329	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Slip_2331	COG0492	ferredoxin-NADP+ reductase activity
Slip_2332	COG1196	nuclear chromosome segregation
Slip_2332	COG0739	heme binding
Slip_2332	COG0741	lytic transglycosylase activity
Slip_2340	COG2814	Major facilitator Superfamily
Slip_2342	COG1309	transcriptional regulator
Slip_2343	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Slip_2344	COG0359	binds to the 23S rRNA
Slip_2346	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Slip_2347	COG0629	single-stranded DNA binding
Slip_2348	COG0360	Binds together with S18 to 16S ribosomal RNA
Slip_2354	COG1362	aminopeptidase activity
Slip_2357	COG0516	GMP reductase activity
Slip_2357	COG0517	IMP dehydrogenase activity
Slip_2359	COG0411	ABC transporter
Slip_2361	COG0559	Belongs to the binding-protein-dependent transport system permease family
Slip_2363	COG1924	4 iron, 4 sulfur cluster binding
Slip_2367	COG1921	L-seryl-tRNASec selenium transferase activity
Slip_2368	COG3949	Membrane
Slip_2375	COG1475	DNA binding
Slip_2376	COG1192	Involved in chromosome partitioning
Slip_2377	COG1475	DNA binding
Slip_2378	COG0357	Ribosomal RNA small subunit methyltransferase G
Slip_2379	COG0445	tRNA wobble uridine modification
Slip_2380	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Slip_2381	COG1847	R3H domain protein
Slip_2382	COG0706	membrane insertase activity
Slip_2383	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Slip_2384	COG0594	ribonuclease P activity
Slip_2385	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Slip_R0041	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs