locus-tag	class	description
SYN_00001	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SYN_00005	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SYN_00014	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SYN_00017	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYN_00019	COG1278	Cold shock
SYN_00021	COG1454	alcohol dehydrogenase
SYN_00023	COG1136	(ABC) transporter
SYN_00023	COG0577	efflux transmembrane transporter activity
SYN_00024	COG1136	(ABC) transporter
SYN_00025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_00026	COG0484	heat shock protein binding
SYN_00027	COG0459	protein refolding
SYN_00028	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SYN_00029	COG0071	Belongs to the small heat shock protein (HSP20) family
SYN_00038	COG0343	queuine tRNA-ribosyltransferase activity
SYN_00039	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SYN_00041	COG3956	TIGRFAM MazG family protein
SYN_00042	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SYN_00054	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SYN_00056	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYN_00057	COG0573	inorganic phosphate transmembrane transporter activity
SYN_00058	COG0581	inorganic phosphate transmembrane transporter activity
SYN_00059	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYN_00061	COG5002	protein histidine kinase activity
SYN_00062	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SYN_00063	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYN_00064	COG0085	RNA polymerase activity
SYN_00066	COG0222	ribosome binding
SYN_00067	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SYN_00068	COG0081	regulation of translation
SYN_00069	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SYN_00072	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SYN_00073	COG2078	PFAM AMMECR1 domain protein
SYN_00074	COG1355	regulation of microtubule-based process
SYN_00075	COG0215	cysteine-tRNA ligase activity
SYN_00077	COG0725	ABC transporter, periplasmic molybdate-binding protein
SYN_00079	COG3842	ATPase activity
SYN_00081	COG0489	protein tyrosine kinase activity
SYN_00083	COG1473	amidohydrolase
SYN_00084	COG0655	NAD(P)H dehydrogenase (quinone) activity
SYN_00088	COG0473	3-isopropylmalate dehydrogenase activity
SYN_00090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYN_00091	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SYN_00092	COG0066	3-isopropylmalate dehydratase activity
SYN_00093	COG0430	RNA-3'-phosphate cyclase activity
SYN_00100	COG0456	acetyltransferase
SYN_00101	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SYN_00102	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SYN_00104	COG0728	peptidoglycan biosynthetic process
SYN_00105	COG1872	DUF167
SYN_00106	COG0762	integral membrane protein
SYN_00110	COG0484	heat shock protein binding
SYN_00111	COG0662	Cupin 2, conserved barrel domain protein
SYN_00112	COG4191	Histidine kinase
SYN_00112	COG0745	RESPONSE REGULATOR receiver
SYN_00112	COG2205	protein histidine kinase activity
SYN_00121	COG4974	Belongs to the 'phage' integrase family
SYN_00122	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SYN_00123	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SYN_00124	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SYN_00133	COG1560	Kdo2-lipid A biosynthetic process
SYN_00137	COG2835	tetraacyldisaccharide 4'-kinase activity
SYN_00140	COG2414	aldehyde ferredoxin oxidoreductase
SYN_00145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SYN_00149	COG1333	cytochrome c biogenesis protein
SYN_00150	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SYN_00154	COG1013	pyruvate-flavodoxin oxidoreductase activity
SYN_00155	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYN_00158	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SYN_00158	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SYN_00162	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SYN_00163	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SYN_00164	COG0590	tRNA wobble adenosine to inosine editing
SYN_00166	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SYN_00167	COG0012	GTP binding
SYN_00168	COG0436	Aminotransferase
SYN_00169	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SYN_00176	COG0646	methionine synthase
SYN_00176	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SYN_00183	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SYN_00188	COG0823	Involved in the tonB-independent uptake of proteins
SYN_00189	COG2885	chlorophyll binding
SYN_00193	COG2861	carbohydrate metabolic process
SYN_00194	COG0793	Belongs to the peptidase S41A family
SYN_00197	COG1322	Protein conserved in bacteria
SYN_00200	COG0419	ATPase involved in DNA repair
SYN_00201	COG0420	3'-5' exonuclease activity
SYN_00206	COG0306	phosphate transporter
SYN_00208	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SYN_00209	COG1122	ATPase activity
SYN_00210	COG1268	BioY protein
SYN_00211	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SYN_00211	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SYN_00212	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SYN_00216	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SYN_00217	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SYN_00221	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SYN_00221	COG0116	Belongs to the methyltransferase superfamily
SYN_00222	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SYN_00232	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SYN_00233	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SYN_00234	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SYN_00240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_00241	COG1131	(ABC) transporter
SYN_00242	COG1131	(ABC) transporter
SYN_00243	COG0842	Transport permease protein
SYN_00244	COG0842	Transport permease protein
SYN_00248	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYN_00253	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
SYN_00259	COG0247	lactate metabolic process
SYN_00259	COG2181	nitrate reductase activity
SYN_00261	COG2414	aldehyde ferredoxin oxidoreductase
SYN_00265	COG1012	belongs to the aldehyde dehydrogenase family
SYN_00268	COG3585	molybdate ion transport
SYN_00269	COG0725	ABC transporter, periplasmic molybdate-binding protein
SYN_00270	COG4149	molybdate abc transporter
SYN_00271	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SYN_00272	COG0303	'Molybdopterin
SYN_00275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SYN_00283	COG1136	(ABC) transporter
SYN_00285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_00286	COG1796	DNA polymerase
SYN_00286	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SYN_00287	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SYN_00288	COG3058	Necessary for formate dehydrogenase activity
SYN_00289	COG1763	Mo-molybdopterin cofactor biosynthetic process
SYN_00291	COG0328	RNA-DNA hybrid ribonuclease activity
SYN_00294	COG0501	Belongs to the peptidase M48B family
SYN_00295	COG0366	Alpha amylase catalytic
SYN_00297	COG2226	methyltransferase
SYN_00298	COG0058	SHG alpha-glucan phosphorylase activity
SYN_00302	COG0352	thiamine-phosphate diphosphorylase activity
SYN_00303	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SYN_00305	COG0805	protein transport
SYN_00306	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYN_00307	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYN_00308	COG0154	amidase activity
SYN_00309	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYN_00310	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SYN_00311	COG0546	phosphoglycolate phosphatase activity
SYN_00314	COG0589	response to stress
SYN_00316	COG0277	FAD linked oxidase domain protein
SYN_00318	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYN_00323	COG1994	Peptidase M50
SYN_00323	COG0517	IMP dehydrogenase activity
SYN_00326	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SYN_00327	COG0456	acetyltransferase
SYN_00329	COG0542	response to heat
SYN_00331	COG0519	Catalyzes the synthesis of GMP from XMP
SYN_00340	COG0798	PFAM Bile acid sodium symporter
SYN_00347	COG0640	Transcriptional regulator
SYN_00348	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SYN_00359	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SYN_00362	COG0398	Pfam SNARE associated Golgi protein
SYN_00366	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYN_00368	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SYN_00369	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SYN_00370	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SYN_00371	COG1924	4 iron, 4 sulfur cluster binding
SYN_00372	COG2226	methyltransferase
SYN_00381	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SYN_00383	COG1111	helicase
SYN_00383	COG1205	dead DEAH box helicase
SYN_00387	COG0306	phosphate transporter
SYN_00391	COG1879	ABC-type sugar transport system periplasmic component
SYN_00393	COG2827	Endonuclease containing a URI domain
SYN_00397	COG1484	DNA-dependent DNA replication
SYN_00409	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SYN_00410	COG1127	ABC transporter
SYN_00411	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SYN_00412	COG1181	Belongs to the D-alanine--D-alanine ligase family
SYN_00414	COG0795	lipopolysaccharide-transporting ATPase activity
SYN_00416	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SYN_00419	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SYN_00420	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SYN_00421	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SYN_00423	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SYN_00426	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SYN_00429	COG0708	Exodeoxyribonuclease III
SYN_00430	COG2201	protein-glutamate methylesterase activity
SYN_00432	COG0840	transmembrane signaling receptor activity
SYN_00433	COG0835	chemotaxis
SYN_00437	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SYN_00440	COG2022	thiamine diphosphate biosynthetic process
SYN_00442	COG0352	thiamine-phosphate diphosphorylase activity
SYN_00446	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SYN_00449	COG1196	nuclear chromosome segregation
SYN_00449	COG0741	lytic transglycosylase activity
SYN_00449	COG0739	heme binding
SYN_00457	COG1459	type II secretion system
SYN_00458	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SYN_00463	COG2226	methyltransferase
SYN_00465	COG0552	protein localization to endoplasmic reticulum
SYN_00466	COG0488	(ABC) transporter
SYN_00468	COG1283	sodium-dependent phosphate transmembrane transporter activity
SYN_00469	COG1592	Rubrerythrin
SYN_00473	COG0432	Pfam Uncharacterised protein family UPF0047
SYN_00474	COG1691	(AIR) carboxylase
SYN_00475	COG1606	tRNA processing
SYN_00476	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SYN_00477	COG0864	Transcriptional regulator
SYN_00478	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYN_00481	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SYN_00483	COG1199	ATP-dependent helicase activity
SYN_00494	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SYN_00497	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SYN_00511	COG1773	rubredoxin
SYN_00511	COG0426	domain, Protein
SYN_00514	COG0655	NAD(P)H dehydrogenase (quinone) activity
SYN_00515	COG0586	Pfam SNARE associated Golgi protein
SYN_00521	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYN_00522	COG0047	phosphoribosylformylglycinamidine synthase activity
SYN_00527	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYN_00530	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SYN_00532	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SYN_00533	COG0617	tRNA 3'-terminal CCA addition
SYN_00534	COG1408	metallophosphoesterase
SYN_00535	COG1704	LemA family
SYN_00542	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SYN_00543	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SYN_00544	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SYN_00545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SYN_00546	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SYN_00547	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYN_00548	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYN_00549	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYN_00550	COG0772	Belongs to the SEDS family
SYN_00551	COG0768	penicillin binding
SYN_00554	COG1077	Cell shape determining protein MreB Mrl
SYN_00555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SYN_00558	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYN_00558	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYN_00559	COG1774	PSP1 C-terminal conserved region
SYN_00561	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SYN_00564	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYN_00570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SYN_00571	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SYN_00572	COG0424	maF-like protein
SYN_00576	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SYN_00578	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYN_00578	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYN_00579	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SYN_00581	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SYN_00583	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SYN_00584	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SYN_00585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYN_00588	COG0356	it plays a direct role in the translocation of protons across the membrane
SYN_00589	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SYN_00590	COG2204	response regulator
SYN_00595	COG0375	protein maturation
SYN_00597	COG0298	carbon dioxide binding
SYN_00599	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SYN_00600	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SYN_00604	COG0437	4 iron, 4 sulfur cluster binding
SYN_00606	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYN_00606	COG0493	'glutamate synthase
SYN_00607	COG0543	2 iron, 2 sulfur cluster binding
SYN_00609	COG0556	nucleotide-excision repair
SYN_00610	COG1119	ATPase activity
SYN_00611	COG1073	alpha beta
SYN_00615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SYN_00619	COG0613	PHP domain protein
SYN_00621	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SYN_00622	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SYN_00626	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SYN_00628	COG2878	Part of a membrane complex involved in electron transport
SYN_00628	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYN_00629	COG3383	formate dehydrogenase (NAD+) activity
SYN_00630	COG3383	formate dehydrogenase (NAD+) activity
SYN_00633	COG0437	4 iron, 4 sulfur cluster binding
SYN_00639	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYN_00640	COG0305	Participates in initiation and elongation during chromosome replication
SYN_00641	COG0359	binds to the 23S rRNA
SYN_00643	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SYN_00646	COG0045	succinate-CoA ligase (ADP-forming) activity
SYN_00646	COG1042	CoA-binding domain protein
SYN_00646	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SYN_00652	COG1846	Transcriptional regulator
SYN_00654	COG0280	phosphate acetyltransferase
SYN_00664	COG0076	glutamate decarboxylase activity
SYN_00666	COG3040	lipid binding
SYN_00667	COG2226	methyltransferase
SYN_00674	COG0433	COG0433 Predicted ATPase
SYN_00687	COG1874	Beta-galactosidase
SYN_00687	COG0366	Alpha amylase catalytic
SYN_00688	COG2321	neutral zinc metallopeptidase
SYN_00689	COG3647	Membrane
SYN_00691	COG1013	pyruvate-flavodoxin oxidoreductase activity
SYN_00692	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYN_00693	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SYN_00695	COG0582	viral genome integration into host DNA
SYN_00706	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SYN_00708	COG1837	Belongs to the UPF0109 family
SYN_00716	COG2816	NAD+ diphosphatase activity
SYN_00719	COG1937	Protein conserved in bacteria
SYN_00720	COG0437	4 iron, 4 sulfur cluster binding
SYN_00720	COG3064	Membrane
SYN_00725	COG0484	heat shock protein binding
SYN_00730	COG0564	pseudouridine synthase activity
SYN_00731	COG2081	HI0933 family
SYN_00740	COG0123	including yeast histone deacetylase and acetoin utilization protein
SYN_00741	COG1305	Transglutaminase-like
SYN_00744	COG0714	Associated with various cellular activities
SYN_00745	COG1136	(ABC) transporter
SYN_00748	COG1042	CoA-binding domain protein
SYN_00748	COG0045	succinate-CoA ligase (ADP-forming) activity
SYN_00748	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SYN_00752	COG1534	Rna-binding protein
SYN_00756	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SYN_00758	COG0358	DNA primase activity
SYN_00759	COG1610	YqeY-like protein
SYN_00760	COG0537	adenosine 5'-monophosphoramidase activity
SYN_00761	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SYN_00765	COG0228	four-way junction DNA binding
SYN_00766	COG1837	Belongs to the UPF0109 family
SYN_00767	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SYN_00768	COG0336	Belongs to the RNA methyltransferase TrmD family
SYN_00769	COG4752	Belongs to the RNA methyltransferase TrmD family
SYN_00770	COG0335	large ribosomal subunit rRNA binding
SYN_00771	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SYN_00772	COG0792	nuclease activity
SYN_00774	COG1131	(ABC) transporter
SYN_00776	COG4191	Histidine kinase
SYN_00778	COG3409	Peptidoglycan-binding domain 1 protein
SYN_00778	COG3267	Type II secretory pathway component ExeA
SYN_00779	COG0489	protein tyrosine kinase activity
SYN_00783	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SYN_00791	COG1160	GTP binding
SYN_00792	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SYN_00794	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SYN_00796	COG0571	ribonuclease III activity
SYN_00797	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYN_00798	COG0482	sulfurtransferase activity
SYN_00814	COG4968	Prepilin-type N-terminal cleavage methylation domain
SYN_00817	COG0438	transferase activity, transferring glycosyl groups
SYN_00818	COG0438	transferase activity, transferring glycosyl groups
SYN_00822	COG1216	Glycosyl transferase, family 2
SYN_00826	COG2226	methyltransferase
SYN_00827	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SYN_00829	COG0463	Glycosyl transferase, family 2
SYN_00833	COG1305	Transglutaminase-like
SYN_00842	COG0528	UMP kinase activity
SYN_00846	COG0471	metal ion transport
SYN_00848	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SYN_00852	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_00853	COG0577	efflux transmembrane transporter activity
SYN_00853	COG1136	(ABC) transporter
SYN_00854	COG1136	(ABC) transporter
SYN_00854	COG0577	efflux transmembrane transporter activity
SYN_00856	COG1215	transferase activity, transferring glycosyl groups
SYN_00858	COG1649	PFAM Uncharacterised BCR, COG1649
SYN_00858	COG0726	polysaccharide deacetylase
SYN_00864	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SYN_00864	COG4651	solute:proton antiporter activity
SYN_00867	COG1215	transferase activity, transferring glycosyl groups
SYN_00868	COG0463	Glycosyl transferase, family 2
SYN_00869	COG2379	hydroxypyruvate reductase
SYN_00870	COG3769	mannosylglycerate metabolic process
SYN_00879	COG0058	SHG alpha-glucan phosphorylase activity
SYN_00881	COG0438	transferase activity, transferring glycosyl groups
SYN_00885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SYN_00887	COG0205	6-phosphofructokinase activity
SYN_00888	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SYN_00889	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SYN_00891	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SYN_00892	COG0824	Thioesterase
SYN_00894	COG0484	heat shock protein binding
SYN_00897	COG0516	GMP reductase activity
SYN_00897	COG0517	IMP dehydrogenase activity
SYN_00899	COG1490	D-aminoacyl-tRNA deacylase activity
SYN_00901	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SYN_00902	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SYN_00903	COG0860	N-Acetylmuramoyl-L-alanine amidase
SYN_00905	COG0442	prolyl-tRNA aminoacylation
SYN_00906	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SYN_00907	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SYN_00908	COG0436	Aminotransferase
SYN_00909	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SYN_00910	COG0742	ribosomal rna small subunit methyltransferase
SYN_00911	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SYN_00912	COG1183	phosphatidylcholine synthase activity
SYN_00913	COG0688	phosphatidylethanolamine metabolic process
SYN_00914	COG1214	PFAM Peptidase M22, glycoprotease
SYN_00915	COG0750	zinc metalloprotease
SYN_00917	COG4589	Belongs to the CDS family
SYN_00918	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SYN_00919	COG0233	cytoplasmic translational termination
SYN_00920	COG0528	UMP kinase activity
SYN_00922	COG1136	(ABC) transporter
SYN_00924	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SYN_00926	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYN_00928	COG0483	inositol monophosphate 1-phosphatase activity
SYN_00934	COG0427	acetyl-CoA hydrolase
SYN_00935	COG0427	acetyl-CoA hydrolase
SYN_00941	COG1660	Displays ATPase and GTPase activities
SYN_00943	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SYN_00944	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SYN_00945	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SYN_00949	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SYN_00950	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SYN_00952	COG4974	Belongs to the 'phage' integrase family
SYN_00954	COG0803	Belongs to the bacterial solute-binding protein 9 family
SYN_00954	COG3443	Belongs to the bacterial solute-binding protein 9 family
SYN_00955	COG1121	(ABC) transporter
SYN_00956	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYN_00960	COG1360	Flagellar Motor Protein
SYN_00962	COG0745	RESPONSE REGULATOR receiver
SYN_00963	COG0643	Histidine kinase
SYN_00963	COG2198	Histidine kinase
SYN_00964	COG2201	protein-glutamate methylesterase activity
SYN_00965	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SYN_00969	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SYN_00970	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SYN_00971	COG0840	transmembrane signaling receptor activity
SYN_00974	COG0745	RESPONSE REGULATOR receiver
SYN_00975	COG0835	chemotaxis
SYN_00977	COG0840	transmembrane signaling receptor activity
SYN_00977	COG3290	protein histidine kinase activity
SYN_00978	COG0840	transmembrane signaling receptor activity
SYN_00979	COG0686	Belongs to the AlaDH PNT family
SYN_00981	COG0745	RESPONSE REGULATOR receiver
SYN_00982	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SYN_00983	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SYN_00984	COG0051	transcription antitermination factor activity, RNA binding
SYN_00985	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SYN_00986	COG0088	Forms part of the polypeptide exit tunnel
SYN_00987	COG0089	rRNA binding
SYN_00988	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SYN_00989	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SYN_00990	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SYN_00991	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SYN_00992	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SYN_00993	COG0255	Belongs to the universal ribosomal protein uL29 family
SYN_00994	COG0018	arginyl-trna synthetase
SYN_00996	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SYN_01000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SYN_01002	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SYN_01003	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SYN_01006	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SYN_01012	COG0594	ribonuclease P activity
SYN_01013	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SYN_01014	COG0706	membrane insertase activity
SYN_01015	COG1847	R3H domain protein
SYN_01016	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYN_01020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SYN_01022	COG1234	tRNA 3'-trailer cleavage
SYN_01023	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SYN_01029	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SYN_01032	COG0052	Belongs to the universal ribosomal protein uS2 family
SYN_01033	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SYN_01035	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SYN_01036	COG0653	protein targeting
SYN_01037	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SYN_01040	COG0511	ligase activity, forming carbon-carbon bonds
SYN_01040	COG5016	pyruvate
SYN_01041	COG0439	Biotin carboxylase
SYN_01045	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SYN_01045	COG3608	succinylglutamate desuccinylase aspartoacylase
SYN_01048	COG4772	TonB-dependent receptor
SYN_01050	COG0500	methyltransferase
SYN_01052	COG0848	biopolymer transport protein
SYN_01053	COG0811	peptide transport
SYN_01054	COG1120	ATPase activity
SYN_01057	COG2226	methyltransferase
SYN_01064	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SYN_01064	COG2885	chlorophyll binding
SYN_01066	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SYN_01069	COG1640	4-alpha-glucanotransferase
SYN_01071	COG1104	cysteine desulfurase activity
SYN_01072	COG0425	Belongs to the sulfur carrier protein TusA family
SYN_01077	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SYN_01077	COG2205	protein histidine kinase activity
SYN_01079	COG3706	GGDEF domain
SYN_01079	COG0745	RESPONSE REGULATOR receiver
SYN_01080	COG3263	regulation of cellular component size
SYN_01083	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SYN_01084	COG1619	proteins homologs of microcin C7 resistance protein MccF
SYN_01085	COG2715	membrane protein required for spore maturation
SYN_01086	COG0700	Nucleoside recognition
SYN_01091	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SYN_01092	COG0569	domain protein
SYN_01094	COG5002	protein histidine kinase activity
SYN_01096	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYN_01101	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SYN_01101	COG0438	transferase activity, transferring glycosyl groups
SYN_01103	COG1216	Glycosyl transferase, family 2
SYN_01103	COG1442	glycosyl transferase family 8
SYN_01107	COG1216	Glycosyl transferase, family 2
SYN_01108	COG0463	Glycosyl transferase, family 2
SYN_01128	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SYN_01129	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SYN_01130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYN_01139	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SYN_01141	COG0438	transferase activity, transferring glycosyl groups
SYN_01142	COG0438	transferase activity, transferring glycosyl groups
SYN_01146	COG1960	acyl-CoA dehydrogenase activity
SYN_01149	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SYN_01156	COG1067	ATP-dependent peptidase activity
SYN_01158	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYN_01166	COG2181	nitrate reductase activity
SYN_01166	COG0247	lactate metabolic process
SYN_01173	COG0731	radical SAM domain protein
SYN_01173	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SYN_01181	COG2204	response regulator
SYN_01184	COG1945	arginine decarboxylase activity
SYN_01185	COG0489	protein tyrosine kinase activity
SYN_01187	COG0489	protein tyrosine kinase activity
SYN_01195	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SYN_01200	COG2116	formate transmembrane transporter activity
SYN_01208	COG1253	flavin adenine dinucleotide binding
SYN_01210	COG3426	butyrate kinase activity
SYN_01211	COG0280	phosphate acetyltransferase
SYN_01213	COG0549	Belongs to the carbamate kinase family
SYN_01218	COG2223	nitrite transmembrane transporter activity
SYN_01223	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SYN_01225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SYN_01229	COG0655	NAD(P)H dehydrogenase (quinone) activity
SYN_01236	COG0840	transmembrane signaling receptor activity
SYN_01241	COG0517	IMP dehydrogenase activity
SYN_01248	COG2076	Multidrug Resistance protein
SYN_01250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SYN_01251	COG1104	cysteine desulfurase activity
SYN_01253	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SYN_01256	COG0482	sulfurtransferase activity
SYN_01257	COG1045	serine acetyltransferase
SYN_01259	COG2890	protein-(glutamine-N5) methyltransferase activity
SYN_01260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SYN_01261	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYN_01261	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYN_01262	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SYN_01263	COG1127	ABC transporter
SYN_01266	COG2853	Lipoprotein
SYN_01273	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYN_01274	COG1674	ftsk spoiiie
SYN_01278	COG1561	YicC-like family, N-terminal region
SYN_01279	COG0194	GDP metabolic process
SYN_01280	COG1758	RNA polymerase activity
SYN_01281	COG0284	orotidine-5'-phosphate decarboxylase activity
SYN_01282	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYN_01287	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYN_01291	COG4191	Histidine kinase
SYN_01291	COG0784	Response regulator, receiver
SYN_01292	COG0745	RESPONSE REGULATOR receiver
SYN_01293	COG0778	Nitroreductase
SYN_01294	COG1335	isochorismatase
SYN_01297	COG1278	Cold shock
SYN_01299	COG1605	Chorismate mutase
SYN_01299	COG0077	Prephenate dehydratase
SYN_01300	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SYN_01305	COG1403	HNH endonuclease
SYN_01308	COG1469	GTP cyclohydrolase I activity
SYN_01309	COG1024	Enoyl-CoA hydratase
SYN_01310	COG1250	3-hydroxyacyl-CoA dehydrogenase
SYN_01313	COG2135	peptidase activity
SYN_01314	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SYN_01320	COG3089	Belongs to the UPF0270 family
SYN_01324	COG0745	RESPONSE REGULATOR receiver
SYN_01324	COG3706	GGDEF domain
SYN_01325	COG3328	transposase activity
SYN_01335	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
SYN_01336	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SYN_01337	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SYN_01339	COG0799	negative regulation of ribosome biogenesis
SYN_01341	COG0601	transmembrane transport
SYN_01342	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SYN_01347	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SYN_01348	COG0322	excinuclease ABC activity
SYN_01349	COG2119	membrane
SYN_01350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SYN_01351	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SYN_01352	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SYN_01353	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SYN_01363	COG0745	RESPONSE REGULATOR receiver
SYN_01364	COG4191	Histidine kinase
SYN_01365	COG1945	arginine decarboxylase activity
SYN_01372	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYN_01373	COG2204	response regulator
SYN_01375	COG3189	MarR family transcriptional regulator
SYN_01377	COG2414	aldehyde ferredoxin oxidoreductase
SYN_01378	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SYN_01383	COG1773	rubredoxin
SYN_01385	COG1773	rubredoxin
SYN_01387	COG2801	Transposase and inactivated derivatives
SYN_01390	COG0137	argininosuccinate synthase activity
SYN_01394	COG1091	dTDP-4-dehydrorhamnose reductase activity
SYN_01395	COG0101	tRNA pseudouridine synthase activity
SYN_01396	COG0126	phosphoglycerate kinase activity
SYN_01398	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SYN_01399	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SYN_01400	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SYN_01401	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SYN_01402	COG4956	integral membrane protein (PIN domain superfamily)
SYN_01404	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SYN_01405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SYN_01406	COG1950	PFAM Membrane protein of
SYN_01407	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SYN_01408	COG0791	NLP P60 protein
SYN_01409	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SYN_01411	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SYN_01413	COG0741	lytic transglycosylase activity
SYN_01421	COG1301	dicarboxylic acid transport
SYN_01423	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SYN_01425	COG4771	TonB-dependent receptor
SYN_01426	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SYN_01427	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SYN_01431	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SYN_01437	COG1278	Cold shock
SYN_01440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SYN_01441	COG0446	pyridine nucleotide-disulphide oxidoreductase
SYN_01444	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYN_01445	COG1324	tolerance protein
SYN_01447	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SYN_01448	COG1331	Highly conserved protein containing a thioredoxin domain
SYN_01451	COG0107	imidazoleglycerol-phosphate synthase activity
SYN_01453	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SYN_01454	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SYN_01456	COG0842	Transport permease protein
SYN_01457	COG0842	Transport permease protein
SYN_01458	COG2095	MarC family integral membrane protein
SYN_01459	COG1131	(ABC) transporter
SYN_01460	COG1131	(ABC) transporter
SYN_01461	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_01465	COG4191	Histidine kinase
SYN_01466	COG2204	response regulator
SYN_01467	COG1815	bacterial-type flagellum-dependent cell motility
SYN_01469	COG1677	Flagellar hook-basal body complex protein FliE
SYN_01471	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SYN_01473	COG1157	protein secretion by the type III secretion system
SYN_01478	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SYN_01482	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SYN_01483	COG1181	Belongs to the D-alanine--D-alanine ligase family
SYN_01486	COG0791	NLP P60 protein
SYN_01492	COG4964	Belongs to the GSP D family
SYN_01496	COG0489	protein tyrosine kinase activity
SYN_01505	COG2304	oxidoreductase activity
SYN_01510	COG2026	Addiction module toxin, RelE StbE family
SYN_01517	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYN_01518	COG0617	tRNA 3'-terminal CCA addition
SYN_01520	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SYN_01521	COG0352	thiamine-phosphate diphosphorylase activity
SYN_01521	COG0351	phosphomethylpyrimidine kinase
SYN_01522	COG1564	THIamine pyrophosphokinase
SYN_01524	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYN_01525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYN_01528	COG1914	H( )-stimulated, divalent metal cation uptake system
SYN_01529	COG2239	Acts as a magnesium transporter
SYN_01532	COG0540	Belongs to the ATCase OTCase family
SYN_01533	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SYN_01534	COG2239	Acts as a magnesium transporter
SYN_01535	COG1381	Involved in DNA repair and RecF pathway recombination
SYN_01536	COG0752	glycyl-tRNA synthetase alpha subunit
SYN_01537	COG0751	glycine-tRNA ligase activity
SYN_01539	COG0589	response to stress
SYN_01550	COG1459	type II secretion system
SYN_01559	COG0720	synthase
SYN_01560	COG0602	queuosine metabolic process
SYN_01561	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SYN_01563	COG1663	tetraacyldisaccharide 4'-kinase activity
SYN_01564	COG1132	(ABC) transporter
SYN_01565	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYN_01566	COG0673	inositol 2-dehydrogenase activity
SYN_01567	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYN_01568	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYN_01572	COG0402	S-adenosylhomocysteine deaminase activity
SYN_01574	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYN_01577	COG1945	arginine decarboxylase activity
SYN_01580	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SYN_01590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SYN_01591	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SYN_01592	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SYN_01593	COG1841	ribosomal large subunit assembly
SYN_01594	COG0200	Binds to the 23S rRNA
SYN_01595	COG0201	protein transport
SYN_01597	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SYN_01598	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SYN_01599	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SYN_01600	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SYN_01601	COG0202	RNA polymerase activity
SYN_01603	COG0203	ribosomal protein L17
SYN_01605	COG1234	tRNA 3'-trailer cleavage
SYN_01607	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SYN_01609	COG2249	NAD(P)H dehydrogenase (quinone) activity
SYN_01619	COG1408	metallophosphoesterase
SYN_01624	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SYN_01625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SYN_01626	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SYN_01626	COG0519	Catalyzes the synthesis of GMP from XMP
SYN_01627	COG0505	Belongs to the CarA family
SYN_01628	COG0174	glutamine synthetase
SYN_01629	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYN_01629	COG0493	'glutamate synthase
SYN_01630	COG0069	glutamate synthase activity
SYN_01630	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SYN_01635	COG2204	response regulator
SYN_01636	COG5002	protein histidine kinase activity
SYN_01638	COG1021	2,3-dihydroxybenzoate-AMP ligase
SYN_01640	COG2414	aldehyde ferredoxin oxidoreductase
SYN_01643	COG2181	nitrate reductase activity
SYN_01643	COG0247	lactate metabolic process
SYN_01649	COG1034	ATP synthesis coupled electron transport
SYN_01650	COG0445	tRNA wobble uridine modification
SYN_01651	COG1242	4 iron, 4 sulfur cluster binding
SYN_01652	COG0006	proline dipeptidase activity
SYN_01653	COG1024	Enoyl-CoA hydratase
SYN_01654	COG1024	Enoyl-CoA hydratase
SYN_01659	COG4657	Part of a membrane complex involved in electron transport
SYN_01661	COG4660	Part of a membrane complex involved in electron transport
SYN_01662	COG4659	FMN binding
SYN_01663	COG4658	electron transport chain
SYN_01664	COG4656	Part of a membrane complex involved in electron transport
SYN_01665	COG0842	Transport permease protein
SYN_01666	COG1131	(ABC) transporter
SYN_01675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SYN_01676	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SYN_01677	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SYN_01680	COG1028	Short-chain dehydrogenase reductase Sdr
SYN_01683	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SYN_01684	COG0107	imidazoleglycerol-phosphate synthase activity
SYN_01685	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SYN_01686	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SYN_01693	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYN_01694	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYN_01695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SYN_01696	COG1028	Short-chain dehydrogenase reductase Sdr
SYN_01697	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SYN_01700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SYN_01701	COG3852	Histidine kinase
SYN_01702	COG2204	response regulator
SYN_01706	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYN_01708	COG0129	dihydroxy-acid dehydratase activity
SYN_01709	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SYN_01711	COG0028	Belongs to the TPP enzyme family
SYN_01713	COG0028	Belongs to the TPP enzyme family
SYN_01717	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SYN_01718	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SYN_01719	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SYN_01720	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SYN_01721	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SYN_01723	COG0072	phenylalanine-tRNA ligase activity
SYN_01724	COG0776	regulation of translation
SYN_01727	COG3716	PTS system mannose fructose sorbose family IID component
SYN_01729	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SYN_01733	COG0148	phosphopyruvate hydratase activity
SYN_01734	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SYN_01735	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SYN_01736	COG2001	Belongs to the MraZ family
SYN_01737	COG0275	rRNA processing
SYN_01738	COG3116	cell division
SYN_01739	COG0768	penicillin binding
SYN_01740	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SYN_01742	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SYN_01743	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYN_01744	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SYN_01746	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SYN_01747	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SYN_01748	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SYN_01763	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SYN_01767	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SYN_01768	COG0509	glycine decarboxylation via glycine cleavage system
SYN_01779	COG0756	dUTP diphosphatase activity
SYN_01780	COG1185	polyribonucleotide nucleotidyltransferase activity
SYN_01782	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SYN_01783	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SYN_01784	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SYN_01785	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SYN_01786	COG1550	Protein conserved in bacteria
SYN_01787	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SYN_01789	COG0195	Participates in both transcription termination and antitermination
SYN_01790	COG0779	Required for maturation of 30S ribosomal subunits
SYN_01792	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SYN_01793	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SYN_01794	COG2890	protein-(glutamine-N5) methyltransferase activity
SYN_01795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SYN_01796	COG0254	rRNA binding
SYN_01798	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SYN_01800	COG0564	pseudouridine synthase activity
SYN_01801	COG1921	L-seryl-tRNASec selenium transferase activity
SYN_01802	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYN_01803	COG0242	peptide deformylase activity
SYN_01804	COG1234	tRNA 3'-trailer cleavage
SYN_01808	COG4191	Histidine kinase
SYN_01814	COG0251	oxidation-reduction process
SYN_01819	COG4942	peptidase
SYN_01827	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYN_01852	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYN_01855	COG2378	regulation of single-species biofilm formation
SYN_01899	COG1484	DNA-dependent DNA replication
SYN_01900	COG4584	PFAM Integrase catalytic
SYN_01901	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SYN_01903	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
SYN_01904	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYN_01906	COG0484	heat shock protein binding
SYN_01907	COG0071	Belongs to the small heat shock protein (HSP20) family
SYN_01908	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SYN_01909	COG0459	protein refolding
SYN_01916	COG0582	viral genome integration into host DNA
SYN_01918	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYN_01919	COG3604	Transcriptional regulator
SYN_01921	COG2204	response regulator
SYN_01923	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SYN_01924	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SYN_01929	COG0513	Belongs to the DEAD box helicase family
SYN_01932	COG2133	pyrroloquinoline quinone binding
SYN_01933	COG1605	Chorismate mutase
SYN_01933	COG0287	Prephenate dehydrogenase
SYN_01934	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SYN_01935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SYN_01936	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SYN_01937	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SYN_01938	COG0710	3-dehydroquinate dehydratase activity
SYN_01939	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SYN_01940	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SYN_01941	COG0159	tryptophan synthase activity
SYN_01943	COG0135	phosphoribosylanthranilate isomerase activity
SYN_01944	COG0134	indole-3-glycerol-phosphate synthase activity
SYN_01945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SYN_01946	COG0512	Glutamine amidotransferase of anthranilate synthase
SYN_01948	COG0196	riboflavin kinase activity
SYN_01949	COG0045	succinate-CoA ligase (ADP-forming) activity
SYN_01949	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SYN_01949	COG1042	CoA-binding domain protein
SYN_01953	COG2197	response regulator
SYN_01954	COG4585	Histidine kinase
SYN_01960	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SYN_01964	COG2921	Belongs to the UPF0250 family
SYN_01965	COG0028	Belongs to the TPP enzyme family
SYN_01966	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SYN_01967	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SYN_01969	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SYN_01974	COG1970	mechanosensitive ion channel activity
SYN_01975	COG1294	oxidase, subunit
SYN_01976	COG1271	oxidase subunit
SYN_01977	COG2050	protein possibly involved in aromatic compounds catabolism
SYN_01978	COG0488	(ABC) transporter
SYN_01980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SYN_01983	COG0443	Heat shock 70 kDa protein
SYN_01984	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SYN_01988	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SYN_01990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SYN_01991	COG0402	S-adenosylhomocysteine deaminase activity
SYN_01993	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_01994	COG1136	(ABC) transporter
SYN_01995	COG0577	efflux transmembrane transporter activity
SYN_01995	COG1136	(ABC) transporter
SYN_01997	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SYN_01998	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SYN_02002	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SYN_02003	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SYN_02005	COG0745	RESPONSE REGULATOR receiver
SYN_02005	COG3706	GGDEF domain
SYN_02006	COG1741	Belongs to the pirin family
SYN_02008	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SYN_02012	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SYN_02019	COG0776	regulation of translation
SYN_02023	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYN_02024	COG0793	Belongs to the peptidase S41A family
SYN_02026	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SYN_02027	COG2137	regulation of response to DNA damage stimulus
SYN_02028	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SYN_02029	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SYN_02030	COG1058	Belongs to the CinA family
SYN_02030	COG1546	Belongs to the CinA family
SYN_02049	COG0187	DNA topoisomerase II activity
SYN_02051	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SYN_02053	COG1192	Involved in chromosome partitioning
SYN_02054	COG0357	Ribosomal RNA small subunit methyltransferase G
SYN_02056	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SYN_02057	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SYN_02058	COG0348	domain, Protein
SYN_02058	COG3901	Regulator of nitric oxide reductase transcription
SYN_02064	COG0842	Transport permease protein
SYN_02065	COG0842	Transport permease protein
SYN_02065	COG1129	ABC transporter
SYN_02066	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_02068	COG3008	intermembrane lipid transfer
SYN_02068	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SYN_02070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SYN_02071	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYN_02073	COG1538	Outer membrane efflux protein
SYN_02074	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SYN_02075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_02076	COG1309	transcriptional regulator
SYN_02078	COG1489	DNA binding
SYN_02080	COG0280	phosphate acetyltransferase
SYN_02081	COG0280	phosphate acetyltransferase
SYN_02089	COG3118	belongs to the thioredoxin family
SYN_02096	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SYN_02097	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SYN_02101	COG0356	it plays a direct role in the translocation of protons across the membrane
SYN_02103	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYN_02104	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SYN_02105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SYN_02108	COG1309	transcriptional regulator
SYN_02118	COG0709	Synthesizes selenophosphate from selenide and ATP
SYN_02121	COG0583	DNA-binding transcription factor activity
SYN_02123	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYN_02123	COG1773	rubredoxin
SYN_02126	COG1104	cysteine desulfurase activity
SYN_02127	COG1028	Short-chain dehydrogenase reductase Sdr
SYN_02128	COG1960	acyl-CoA dehydrogenase activity
SYN_02130	COG0428	transporter
SYN_02134	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SYN_02137	COG3383	formate dehydrogenase (NAD+) activity
SYN_02138	COG3383	formate dehydrogenase (NAD+) activity
SYN_02140	COG2223	nitrite transmembrane transporter activity
SYN_02145	COG0860	N-Acetylmuramoyl-L-alanine amidase
SYN_02149	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYN_02151	COG4974	Belongs to the 'phage' integrase family
SYN_02152	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SYN_02153	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SYN_02154	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SYN_02155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SYN_02156	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SYN_02157	COG0137	argininosuccinate synthase activity
SYN_02158	COG0165	Argininosuccinate lyase
SYN_02160	COG0019	diaminopimelate decarboxylase activity
SYN_02161	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SYN_02162	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SYN_02163	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SYN_02165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SYN_02166	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SYN_02171	COG0444	Belongs to the ABC transporter superfamily
SYN_02172	COG4608	Belongs to the ABC transporter superfamily
SYN_02173	COG2945	thiolester hydrolase activity
SYN_02175	COG1278	Cold shock
SYN_02176	COG1032	radical SAM domain protein
SYN_02177	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SYN_02178	COG1573	uracil-dna glycosylase
SYN_02184	COG1376	ErfK ybiS ycfS ynhG family protein
SYN_02186	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYN_02187	COG0481	GTPase activity
SYN_02188	COG0563	adenylate kinase activity
SYN_02189	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SYN_02190	COG0037	tRNA processing
SYN_02192	COG3481	metal-dependent phosphohydrolase, HD sub domain
SYN_02194	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYN_02195	COG0009	L-threonylcarbamoyladenylate synthase
SYN_02196	COG1530	ribonuclease E activity
SYN_02197	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SYN_02199	COG4783	chaperone-mediated protein folding
SYN_02201	COG1013	pyruvate-flavodoxin oxidoreductase activity
SYN_02201	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYN_02201	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SYN_02201	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYN_02208	COG1918	ferrous iron import across plasma membrane
SYN_02208	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SYN_02211	COG0004	ammonium transporteR
SYN_02212	COG0347	Belongs to the P(II) protein family
SYN_02214	COG2204	response regulator
SYN_02215	COG4191	Histidine kinase
SYN_02218	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYN_02221	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
SYN_02224	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYN_02225	COG0573	inorganic phosphate transmembrane transporter activity
SYN_02226	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYN_02227	COG4974	Belongs to the 'phage' integrase family
SYN_02229	COG3041	Addiction module toxin RelE StbE family
SYN_02232	COG1980	fructose-bisphosphate aldolase activity
SYN_02239	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SYN_02256	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SYN_02257	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SYN_02260	COG1686	Belongs to the peptidase S11 family
SYN_02261	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYN_02261	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYN_02264	COG0737	Belongs to the 5'-nucleotidase family
SYN_02266	COG0535	radical SAM domain protein
SYN_02267	COG0113	porphobilinogen synthase activity
SYN_02268	COG0535	radical SAM domain protein
SYN_02273	COG0181	hydroxymethylbilane synthase activity
SYN_02274	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SYN_02276	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYN_02276	COG1648	precorrin-2 dehydrogenase activity
SYN_02277	COG2264	protein methyltransferase activity
SYN_02278	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SYN_02298	COG4397	Mu-like prophage major head subunit gpT
SYN_02301	COG5005	Phage virion morphogenesis
SYN_02303	COG4383	Mu-like prophage protein gp29
SYN_02351	COG2217	Heavy metal translocating P-type atpase
SYN_02354	COG0671	phosphoesterase, PA-phosphatase related
SYN_02356	COG1366	Belongs to the anti-sigma-factor antagonist family
SYN_02357	COG2172	sigma factor antagonist activity
SYN_02359	COG2208	phosphoserine phosphatase activity
SYN_02360	COG0427	acetyl-CoA hydrolase
SYN_02361	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SYN_02362	COG1399	metal-binding, possibly nucleic acid-binding protein
SYN_02363	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SYN_02364	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYN_02365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYN_02366	COG0698	ribose 5-phosphate isomerase
SYN_02367	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SYN_02369	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SYN_02371	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYN_02371	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYN_02372	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SYN_02373	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYN_02374	COG0495	leucyl-tRNA aminoacylation
SYN_02376	COG0268	Binds directly to 16S ribosomal RNA
SYN_02377	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SYN_02379	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SYN_02380	COG5002	protein histidine kinase activity
SYN_02382	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SYN_02391	COG0463	Glycosyl transferase, family 2
SYN_02394	COG1968	undecaprenyl-diphosphatase activity
SYN_02396	COG0753	catalase activity
SYN_02398	COG1169	isochorismate synthase
SYN_02399	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SYN_02403	COG0729	surface antigen
SYN_02416	COG1309	transcriptional regulator
SYN_02421	COG0247	lactate metabolic process
SYN_02421	COG2181	nitrate reductase activity
SYN_02423	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYN_02423	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SYN_02430	COG0513	Belongs to the DEAD box helicase family
SYN_02432	COG1278	Cold shock
SYN_02436	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SYN_02437	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SYN_02439	COG0151	Belongs to the GarS family
SYN_02440	COG0138	bifunctional purine biosynthesis protein purh
SYN_02442	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SYN_02443	COG0009	L-threonylcarbamoyladenylate synthase
SYN_02446	COG0579	oxidoreductase
SYN_02452	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SYN_02454	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SYN_02455	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SYN_02456	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SYN_02458	COG1722	exodeoxyribonuclease VII activity
SYN_02459	COG1570	exodeoxyribonuclease VII activity
SYN_02473	COG1518	maintenance of DNA repeat elements
SYN_02481	COG0135	phosphoribosylanthranilate isomerase activity
SYN_02485	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYN_02486	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SYN_02487	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SYN_02488	COG1278	Cold shock
SYN_02492	COG1773	rubredoxin
SYN_02494	COG3360	Dodecin
SYN_02498	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYN_02498	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SYN_02499	COG1013	pyruvate-flavodoxin oxidoreductase activity
SYN_02501	COG0045	succinate-CoA ligase (ADP-forming) activity
SYN_02502	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SYN_02520	COG1832	CoA-binding protein
SYN_02523	COG1592	Rubrerythrin
SYN_02525	COG0542	response to heat
SYN_02526	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SYN_02529	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SYN_02529	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SYN_02530	COG2204	response regulator
SYN_02531	COG3852	Histidine kinase
SYN_02533	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SYN_02534	COG0124	histidyl-tRNA synthetase
SYN_02535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SYN_02536	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYN_02538	COG0563	adenylate kinase activity
SYN_02539	COG0456	acetyltransferase
SYN_02541	COG1295	ribonuclease BN
SYN_02543	COG3706	GGDEF domain
SYN_02544	COG0589	response to stress
SYN_02551	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SYN_02552	COG1074	ATP-dependent DNA helicase activity
SYN_02553	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SYN_02557	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SYN_02559	COG1592	Rubrerythrin
SYN_02563	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SYN_02564	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYN_02565	COG0778	Nitroreductase
SYN_02566	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYN_02572	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SYN_02583	COG2270	Major facilitator Superfamily
SYN_02584	COG0514	ATP-dependent DNA helicase (RecQ)
SYN_02586	COG1960	acyl-CoA dehydrogenase activity
SYN_02587	COG1960	acyl-CoA dehydrogenase activity
SYN_02588	COG2197	response regulator
SYN_02589	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SYN_02591	COG0134	indole-3-glycerol-phosphate synthase activity
SYN_02592	COG0135	phosphoribosylanthranilate isomerase activity
SYN_02594	COG0427	acetyl-CoA hydrolase
SYN_02602	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SYN_02603	COG0154	amidase activity
SYN_02604	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYN_02607	COG1042	CoA-binding domain protein
SYN_02607	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SYN_02607	COG0045	succinate-CoA ligase (ADP-forming) activity
SYN_02609	COG0045	succinate-CoA ligase (ADP-forming) activity
SYN_02609	COG1042	CoA-binding domain protein
SYN_02609	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SYN_02614	COG1151	hydroxylamine reductase activity
SYN_02616	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
SYN_02617	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SYN_02618	COG0569	domain protein
SYN_02623	COG0739	heme binding
SYN_02626	COG0438	transferase activity, transferring glycosyl groups
SYN_02628	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SYN_02629	COG0668	transmembrane transport
SYN_02631	COG0668	transmembrane transport
SYN_02632	COG2951	lytic endotransglycosylase activity
SYN_02635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SYN_02636	COG2086	electron transfer activity
SYN_02637	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SYN_02638	COG2181	nitrate reductase activity
SYN_02638	COG0247	lactate metabolic process
SYN_02640	COG0318	PFAM AMP-dependent synthetase and ligase
SYN_02641	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SYN_02642	COG0183	Belongs to the thiolase family
SYN_02643	COG0318	PFAM AMP-dependent synthetase and ligase
SYN_02649	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYN_02659	COG1215	transferase activity, transferring glycosyl groups
SYN_02660	COG1216	Glycosyl transferase, family 2
SYN_02665	COG1215	transferase activity, transferring glycosyl groups
SYN_02667	COG0438	transferase activity, transferring glycosyl groups
SYN_02669	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYN_02677	COG0673	inositol 2-dehydrogenase activity
SYN_02678	COG0367	asparagine synthase
SYN_02686	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SYN_02687	COG0110	maltose O-acetyltransferase activity
SYN_02688	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SYN_02690	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SYN_02692	COG4453	Protein conserved in bacteria
SYN_02699	COG0436	Aminotransferase
SYN_02700	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SYN_02701	COG0101	tRNA pseudouridine synthase activity
SYN_02703	COG1410	methionine synthase
SYN_02703	COG0646	methionine synthase
SYN_02704	COG0850	regulation of cytokinetic process
SYN_02705	COG2894	cell division
SYN_02706	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SYN_02707	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SYN_02708	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SYN_02708	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYN_02709	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYN_02710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SYN_02711	COG0484	heat shock protein binding
SYN_02713	COG2204	response regulator
SYN_02714	COG5000	phosphorelay sensor kinase activity
SYN_02721	COG2199	diguanylate cyclase activity
SYN_02721	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SYN_02722	COG3447	MASE1 domain protein
SYN_02722	COG5001	Diguanylate cyclase
SYN_02722	COG5002	protein histidine kinase activity
SYN_02732	COG3550	peptidyl-serine autophosphorylation
SYN_02733	COG1396	sequence-specific DNA binding
SYN_02739	COG1397	ADP-ribosylglycohydrolase
SYN_02754	COG1196	nuclear chromosome segregation
SYN_02760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYN_02761	COG0058	SHG alpha-glucan phosphorylase activity
SYN_02763	COG0598	Magnesium transport protein CorA
SYN_02766	COG0693	protein deglycase activity
SYN_02767	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SYN_02768	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SYN_02769	COG0193	aminoacyl-tRNA hydrolase activity
SYN_02770	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SYN_02772	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SYN_02773	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SYN_02777	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYN_02778	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SYN_02779	COG0736	holo-[acyl-carrier-protein] synthase activity
SYN_02780	COG0802	atpase or kinase
SYN_02781	COG0527	aspartate kinase activity
SYN_02782	COG1596	polysaccharide export
SYN_02782	COG1555	photosystem II stabilization
SYN_02783	COG0741	lytic transglycosylase activity
SYN_02784	COG0544	peptidyl-prolyl cis-trans isomerase activity
SYN_02785	COG0740	serine-type endopeptidase activity
SYN_02789	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SYN_02790	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SYN_02791	COG0741	lytic transglycosylase activity
SYN_02791	COG1388	LysM domain
SYN_02792	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SYN_02793	COG1480	7TM receptor with intracellular HD hydrolase
SYN_02795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SYN_02796	COG0612	Peptidase, M16
SYN_02797	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYN_02797	COG0758	DNA mediated transformation
SYN_02798	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SYN_02799	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SYN_02800	COG0741	lytic transglycosylase activity
SYN_02801	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SYN_02801	COG2199	diguanylate cyclase activity
SYN_02802	COG2226	methyltransferase
SYN_02803	COG0463	Glycosyl transferase, family 2
SYN_02803	COG0457	Tetratricopeptide repeat
SYN_02809	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SYN_02810	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SYN_02811	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SYN_02812	COG1256	bacterial-type flagellum assembly
SYN_02812	COG4786	Flagellar basal body rod
SYN_02816	COG1706	bacterial-type flagellum-dependent cell motility
SYN_02817	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SYN_02818	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
SYN_02820	COG4787	bacterial-type flagellum-dependent cell motility
SYN_02821	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SYN_02827	COG1191	sigma factor activity
SYN_02828	COG0455	bacterial-type flagellum organization
SYN_02829	COG1419	protein localization to endoplasmic reticulum
SYN_02830	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SYN_02832	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SYN_02833	COG1684	flagellar biosynthetic protein fliR
SYN_02834	COG1987	bacterial-type flagellum assembly
SYN_02835	COG1338	Plays a role in the flagellum-specific transport system
SYN_02836	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SYN_02836	COG1776	CheC inhibitor of MCP methylation
SYN_02845	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SYN_02847	COG0456	acetyltransferase
SYN_02848	COG0543	2 iron, 2 sulfur cluster binding
SYN_02851	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYN_02852	COG1643	Atp-dependent helicase
SYN_02853	COG3072	Adenylate cyclase
SYN_02856	COG1187	pseudouridine synthase activity
SYN_02857	COG0180	Tryptophanyl-tRNA synthetase
SYN_02862	COG0497	DNA recombination
SYN_02863	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYN_02866	COG1088	dTDP-glucose 4,6-dehydratase activity
SYN_02867	COG0719	Fe-S assembly protein
SYN_02870	COG0123	including yeast histone deacetylase and acetoin utilization protein
SYN_02873	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SYN_02876	COG0237	dephospho-CoA kinase activity
SYN_02878	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SYN_02878	COG1042	CoA-binding domain protein
SYN_02878	COG0045	succinate-CoA ligase (ADP-forming) activity
SYN_02880	COG0058	SHG alpha-glucan phosphorylase activity
SYN_02883	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SYN_02886	COG0525	valine-tRNA ligase activity
SYN_02888	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SYN_02889	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SYN_02892	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYN_02908	COG0210	DNA helicase
SYN_02909	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
SYN_02917	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SYN_02922	COG0504	CTP synthase activity
SYN_02923	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SYN_02926	COG0315	cyclic pyranopterin monophosphate synthase activity
SYN_02930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYN_02931	COG0521	Mo-molybdopterin cofactor biosynthetic process
SYN_02935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYN_02936	COG1254	Belongs to the acylphosphatase family
SYN_02937	COG0436	Aminotransferase
SYN_02943	COG0628	permease
SYN_02946	COG1538	Outer membrane efflux protein
SYN_02948	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYN_02950	COG0166	Belongs to the GPI family
SYN_02951	COG0837	glucose binding
SYN_02954	COG0191	fructose-bisphosphate aldolase activity
SYN_02956	COG3604	Transcriptional regulator
SYN_02959	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SYN_02961	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SYN_02965	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYN_02966	COG0574	Belongs to the PEP-utilizing enzyme family
SYN_02966	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SYN_02970	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SYN_02971	COG2255	four-way junction helicase activity
SYN_02972	COG0632	four-way junction helicase activity
SYN_02973	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SYN_02974	COG0217	transcriptional regulatory protein
SYN_02977	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SYN_02978	COG1692	metallophosphoesterase
SYN_02979	COG1418	mRNA catabolic process
SYN_02981	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SYN_02983	COG0149	triose-phosphate isomerase activity
SYN_02985	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SYN_02987	COG3328	transposase activity
SYN_02993	COG1151	hydroxylamine reductase activity
SYN_03003	COG2823	Periplasmic or secreted lipoprotein
SYN_03008	COG1959	2 iron, 2 sulfur cluster binding
SYN_03026	COG0215	cysteine-tRNA ligase activity
SYN_03031	COG0489	protein tyrosine kinase activity
SYN_03032	COG2414	aldehyde ferredoxin oxidoreductase
SYN_03045	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SYN_03046	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SYN_03059	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYN_03061	COG4968	Prepilin-type N-terminal cleavage methylation domain
SYN_03076	COG1024	Enoyl-CoA hydratase
SYN_03078	COG0306	phosphate transporter
SYN_03090	COG3426	butyrate kinase activity
SYN_03096	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYN_03108	COG0131	Imidazoleglycerol-phosphate dehydratase
SYN_03109	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SYN_03110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SYN_03115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SYN_03119	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SYN_03119	COG0662	Cupin 2, conserved barrel domain protein
SYN_03123	COG0489	protein tyrosine kinase activity
SYN_03128	COG0318	PFAM AMP-dependent synthetase and ligase
SYN_03131	COG1881	PFAM PEBP family protein
SYN_03141	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SYN_03142	COG0612	Peptidase, M16
SYN_03145	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SYN_03154	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SYN_03155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SYN_03162	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SYN_03162	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYN_03163	COG1013	pyruvate-flavodoxin oxidoreductase activity
SYN_03192	COG0587	DNA-directed DNA polymerase activity
SYN_03195	COG4783	chaperone-mediated protein folding
SYN_03196	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SYN_03198	COG0616	signal peptide processing
SYN_03199	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYN_03200	COG0776	regulation of translation
SYN_03201	COG2003	Belongs to the UPF0758 family
SYN_03202	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SYN_03204	COG0084	hydrolase, TatD family'
SYN_03213	COG0247	lactate metabolic process
SYN_03213	COG2181	nitrate reductase activity
SYN_03223	COG0459	protein refolding
SYN_03230	COG0501	Belongs to the peptidase M48B family
SYN_03234	COG1584	GPR1 FUN34 yaaH family protein
SYN_03250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SYN_03250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SYN_03252	COG0142	geranyltranstransferase activity
SYN_03254	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SYN_03255	COG0049	tRNA binding
SYN_03256	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SYN_03257	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SYN_03272	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SYN_03279	COG0581	inorganic phosphate transmembrane transporter activity
SYN_03311	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SYN_03313	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SYN_03314	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SYN_03315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SYN_03316	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SYN_03385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SYN_03523	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SYN_03606	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SYN_03628	COG0501	Belongs to the peptidase M48B family
SYN_03643	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYN_03680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYN_03702	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SYN_03778	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SYN_03784	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYN_03787	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SYN_03790	COG0149	triose-phosphate isomerase activity
SYN_03791	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity