locus-tag	class	description
FBF38_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
FBF38_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
FBF38_00115	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
FBF38_00155	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
FBF38_00165	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
FBF38_00170	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
FBF38_00180	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
FBF38_00185	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
FBF38_00195	ENOG41086CI	Bifunctional phosphoglucose phosphomannose isomerase
FBF38_00200	ENOG4107RBB	ABC transporter, permease
FBF38_00205	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
FBF38_00220	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
FBF38_00225	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
FBF38_00235	ENOG4105C75	arginyL-tRNA synthetase
FBF38_00250	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
FBF38_00255	ENOG4105UNS	Pfam:DUF419
FBF38_00265	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
FBF38_00270	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
FBF38_00285	ENOG4105C2M	dna polymerase I
FBF38_00295	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
FBF38_00305	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
FBF38_00315	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
FBF38_00320	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
FBF38_00330	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
FBF38_00345	ENOG4105CN5	Metallo-Beta-Lactamase
FBF38_00350	ENOG4105CNU	cell division protein FtsK
FBF38_00360	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
FBF38_00370	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
FBF38_00380	ENOG4105DX0	Hemolysin A
FBF38_00385	ENOG4105C3G	gtp-binding protein
FBF38_00415	ENOG4107QHF	type ii secretion system protein e
FBF38_00420	ENOG4105CZX	twitching motility protein
FBF38_00460	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
FBF38_00465	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
FBF38_00505	ENOG4105C22	threonyL-tRNA synthetase
FBF38_00510	ENOG41080UX	Methyltransferase
FBF38_00515	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
FBF38_00535	ENOG4108Z4T	Peptidase M50
FBF38_00545	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
FBF38_00550	ENOG4105VJV	50s ribosomal protein L35
FBF38_00555	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
FBF38_00560	ENOG4105C0P	Mg chelatase subunit ChlI
FBF38_00590	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
FBF38_00595	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
FBF38_00630	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
FBF38_00665	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
FBF38_00675	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
FBF38_00680	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
FBF38_00700	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
FBF38_00705	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
FBF38_00710	ENOG4105C25	Primosomal protein n'
FBF38_00730	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
FBF38_00750	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
FBF38_00755	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
FBF38_00765	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
FBF38_00770	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
FBF38_00775	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
FBF38_00820	ENOG4108J3C	UTP-glucose-1-phosphate uridylyltransferase
FBF38_00825	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
FBF38_00830	ENOG4107QJE	Chromosome Partitioning Protein
FBF38_00835	ENOG4105FA0	parb-like partition protein
FBF38_00855	ENOG4105C0H	protease
FBF38_00860	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
FBF38_00870	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
FBF38_00875	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
FBF38_00880	ENOG4105NRA	50s ribosomal protein l31 type b
FBF38_00890	ENOG4105CE9	30S ribosomal protein S2
FBF38_00895	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
FBF38_00900	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
FBF38_00905	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
FBF38_00915	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
FBF38_00920	ENOG4105DZP	Membrane-associated zinc metalloprotease
FBF38_00925	ENOG4108TYN	CAAX amino terminal protease family protein
FBF38_00930	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
FBF38_00935	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
FBF38_00940	ENOG4105CRK	lysyL-tRNA synthetase
FBF38_00950	ENOG4108JU6	CBS domain protein
FBF38_00960	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
FBF38_00965	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
FBF38_00980	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
FBF38_00985	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
FBF38_00990	ENOG4105MS2	ribosomal subunit Interface protein
FBF38_00995	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
FBF38_01010	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
FBF38_01015	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
FBF38_01020	ENOG4105CAK	Cell division ATP-binding protein ftsE
FBF38_01025	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
FBF38_01040	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FBF38_01065	ENOG4105K46	50S ribosomal protein l27
FBF38_01080	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
FBF38_01100	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FBF38_01105	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
FBF38_01110	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
FBF38_01145	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
FBF38_01150	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
FBF38_01160	ENOG4107QUV	Domain protein
FBF38_01165	ENOG4108V6E	Cell division protein mraZ
FBF38_01170	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
FBF38_01180	ENOG4105CJN	penicillin-binding protein
FBF38_01185	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
FBF38_01190	ENOG4105CNI	cell division protein FtsW
FBF38_01195	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
FBF38_01210	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
FBF38_01220	ENOG4108JPV	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
FBF38_01230	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
FBF38_01245	ENOG4105C79	DNA protecting protein DprA
FBF38_01260	ENOG4108PJD	permease
FBF38_01270	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
FBF38_01275	ENOG4107QRP	cobalamin biosynthesis protein CobW
FBF38_01285	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
FBF38_01295	ENOG4105FE9	pseudouridine synthase
FBF38_01300	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FBF38_01325	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FBF38_01330	ENOG4105BZU	Histidine kinase
FBF38_01335	ENOG4108R5T	secreted protein
FBF38_01370	ENOG4105CGK	Exodeoxyribonuclease III
FBF38_01380	ENOG4105W2C	Glycosyl transferase
FBF38_01390	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
FBF38_01400	ENOG4105C5H	ABC transporter
FBF38_01420	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
FBF38_01430	ENOG4108KJP	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
FBF38_01435	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
FBF38_01440	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
FBF38_01445	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
FBF38_01450	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
FBF38_01470	ENOG4105C4R	Atp-dependent dna helicase
FBF38_01490	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
FBF38_01505	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
FBF38_01510	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
FBF38_01515	ENOG4105US7	Histidine kinase
FBF38_01520	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FBF38_01525	ENOG4108IUX	(ABC) transporter
FBF38_01540	ENOG4105C8N	cysteinyl-tRNA synthetase
FBF38_01560	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
FBF38_01565	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
FBF38_01575	ENOG4105CDU	Replicative dna helicase
FBF38_01580	ENOG4105C6E	dna polymerase iii
FBF38_01600	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
FBF38_01605	ENOG4108VZM	50s ribosomal protein L10
FBF38_01620	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
FBF38_01630	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
FBF38_01635	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
FBF38_01640	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
FBF38_01645	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
FBF38_01650	ENOG410683Z	Preprotein translocase SecE subunit
FBF38_01655	ENOG4105BZU	Histidine kinase
FBF38_01675	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
FBF38_01685	ENOG4105W0E	50S ribosomal protein L33
FBF38_01695	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
FBF38_01710	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
FBF38_01745	ENOG4105FA2	dna polymerase iii
FBF38_01750	ENOG4105C34	Pseudouridine synthase
FBF38_01755	ENOG4105C31	Tryptophanyl-tRNA synthetase
FBF38_01780	ENOG4108UJD	30S ribosomal protein S9
FBF38_01785	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
FBF38_01790	ENOG4108ZT0	50S ribosomal protein l17
FBF38_01795	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
FBF38_01800	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
FBF38_01805	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
FBF38_01810	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FBF38_01825	ENOG4105C59	p-type ATPase
FBF38_01845	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
FBF38_01855	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
FBF38_01860	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
FBF38_01870	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
FBF38_01890	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
FBF38_01895	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
FBF38_01900	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FBF38_01905	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
FBF38_01910	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
FBF38_01915	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
FBF38_01920	ENOG41082SA	50s ribosomal protein l29
FBF38_01925	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
FBF38_01930	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
FBF38_01935	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
FBF38_01940	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
FBF38_01945	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FBF38_01950	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
FBF38_01955	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
FBF38_01960	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
FBF38_01970	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
FBF38_01975	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
FBF38_01990	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
FBF38_02005	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
FBF38_02025	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
FBF38_02035	ENOG4108VPT	UPF0234 protein
FBF38_02040	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
FBF38_02045	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
FBF38_02050	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
FBF38_02055	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
FBF38_02065	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
FBF38_02080	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
FBF38_02085	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
FBF38_02090	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
FBF38_02095	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
FBF38_02130	ENOG4105CQB	FAD linked oxidase domain protein
FBF38_02175	ENOG4105CI3	gtp-binding protein typa
FBF38_02185	ENOG4105D1H	recombination factor protein RarA
FBF38_02190	ENOG4107QX8	SPFH domain, Band 7 family protein
FBF38_02215	ENOG4105CG3	alpha amylase, catalytic region
FBF38_02220	ENOG4106H78	methyltransferase
FBF38_02230	ENOG4105CB5	ATP-dependent DNA helicase recG
FBF38_02245	ENOG4105BZ4	penicillin-binding protein
FBF38_02255	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
FBF38_02275	ENOG4105CHV	Transcription elongation factor NusA
FBF38_02300	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
FBF38_02310	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
FBF38_02315	ENOG4105C6K	Malic enzyme
FBF38_02325	ENOG4107QHF	type ii secretion system protein e
FBF38_02335	ENOG4105C0B	DNA polymerase III (alpha subunit)
FBF38_02350	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
FBF38_02355	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
FBF38_02365	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
FBF38_02370	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
FBF38_02380	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
FBF38_02390	ENOG4108URH	decarboxylase
FBF38_02405	ENOG4105D2N	Aldolase
FBF38_02415	ENOG4108HHA	Transketolase
FBF38_02420	ENOG4105DJV	ribulose-phosphate 3-epimerase
FBF38_02425	ENOG4108YZG	isomerase
FBF38_02435	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
FBF38_02440	ENOG4105F0N	pyrophosphate phospho-hydrolase
FBF38_02445	ENOG4105C3M	thioredoxin reductase
FBF38_02455	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
FBF38_02490	ENOG4105BZU	Histidine kinase
FBF38_02495	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FBF38_02510	ENOG4107QN2	dihydrolipoyl dehydrogenase
FBF38_02515	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
FBF38_02525	ENOG4107RDT	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
FBF38_02555	ENOG4105C5H	ABC transporter
FBF38_02565	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
FBF38_02580	ENOG4105VB6	UPF0109 protein
FBF38_02585	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
FBF38_02605	ENOG4105C8T	Leucyl-tRNA synthetase
FBF38_02615	ENOG4105DFU	Cell wall formation (By similarity)
FBF38_02635	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
FBF38_02650	ENOG4108V0P	LemA family
FBF38_02685	ENOG41082T9	Membrane
FBF38_02700	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
FBF38_02705	ENOG4105K63	Thioredoxin
FBF38_02715	ENOG4105BZ1	(ABC) transporter
FBF38_02720	ENOG4105DQR	SNARE associated Golgi
FBF38_02725	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
FBF38_02740	ENOG4105CJB	Exodeoxyribonuclease I
FBF38_02745	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FBF38_02750	ENOG41068JE	domain protein
FBF38_02760	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
FBF38_02770	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
FBF38_02780	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
FBF38_02790	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
FBF38_02815	ENOG4105F8V	Hydrolase, tatD family
FBF38_02820	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
FBF38_02835	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
FBF38_02860	ENOG4105CP7	Triose-phosphate isomerase
FBF38_02885	ENOG4105BZU	Histidine kinase
FBF38_02895	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
FBF38_02900	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
FBF38_02940	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
FBF38_02975	ENOG4107XGT	Cell wall formation (By similarity)
FBF38_03005	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
FBF38_03040	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
FBF38_03050	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
FBF38_03060	ENOG41072GX	Peptidase M22 Glycoprotease
FBF38_03065	ENOG4105K8N	protein family UPF0079, ATPase
FBF38_03070	ENOG4107QHF	type ii secretion system protein e
FBF38_03075	ENOG4105D7Q	type ii secretion system
FBF38_03105	ENOG4105KC9	Modulates RecA activity (By similarity)
FBF38_03115	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
FBF38_03130	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
FBF38_03140	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
FBF38_03145	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
FBF38_03155	ENOG4105CDY	transcriptional regulatory protein
FBF38_03180	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
FBF38_03190	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
FBF38_03195	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
FBF38_03200	ENOG4105CFG	Acts as a chaperone (By similarity)
FBF38_03205	ENOG4107Z9D	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FBF38_03210	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
FBF38_03220	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
FBF38_03225	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
FBF38_03240	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
FBF38_03250	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
FBF38_03255	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
FBF38_03310	ENOG4105DFU	Cell wall formation (By similarity)
FBF38_03320	ENOG4107T6Z	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
FBF38_03325	ENOG4105D8X	mechanosensitive ion channel
FBF38_03360	ENOG4105C9M	aspartyl-trna synthetase
FBF38_03375	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
FBF38_03390	ENOG4105C5B	carbamate kinase
FBF38_03395	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
FBF38_03400	ENOG4105DBV	ornithine carbamoyltransferase
FBF38_03405	ENOG4105CEU	Arginine dihydrolase
FBF38_03420	ENOG4105BZ1	(ABC) transporter
FBF38_03435	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
FBF38_03445	ENOG4105E5Q	amino acid AbC transporter
FBF38_03450	ENOG4108HW3	(ABC) transporter
FBF38_03460	ENOG4105CMR	udp-glucose 4-epimerase
FBF38_03465	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
FBF38_03495	ENOG4105CJ1	ABC, transporter
FBF38_03500	ENOG4108ZJ4	polysaccharide deacetylase
FBF38_03510	ENOG4105DZR	Type I site-specific deoxyribonuclease
FBF38_03555	ENOG4105CVR	type I restriction-modification system
FBF38_03560	ENOG4105W5Q	DNA repair protein (RadC
FBF38_03570	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
FBF38_03580	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
FBF38_03610	ENOG4105D3Q	Sugar transferase
FBF38_03625	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
FBF38_03630	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
FBF38_03640	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
FBF38_03645	ENOG4105CKK	Glycosyl transferase, family 2
FBF38_03705	ENOG4105EY8	ABC transporter
FBF38_03735	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins