locus-tag	class	description
FBF37_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
FBF37_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
FBF37_00090	ENOG4105VN1	Heat shock protein
FBF37_00095	ENOG41081UC	Inherit from COG: Competence protein
FBF37_00100	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
FBF37_00145	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
FBF37_00150	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
FBF37_00155	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
FBF37_00165	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
FBF37_00170	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
FBF37_00180	ENOG41086CI	Bifunctional phosphoglucose phosphomannose isomerase
FBF37_00185	ENOG4107RBB	ABC transporter, permease
FBF37_00190	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
FBF37_00205	ENOG4107Y2X	deaminase
FBF37_00210	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
FBF37_00215	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
FBF37_00230	ENOG4105C75	arginyL-tRNA synthetase
FBF37_00250	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
FBF37_00255	ENOG4105UNS	Pfam:DUF419
FBF37_00270	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
FBF37_00280	ENOG4105C2M	dna polymerase I
FBF37_00285	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
FBF37_00295	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
FBF37_00305	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
FBF37_00315	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
FBF37_00325	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
FBF37_00335	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
FBF37_00345	ENOG41062ES	Transcriptional regulator
FBF37_00350	ENOG4105ECB	domain protein
FBF37_00355	ENOG4105CN5	Metallo-Beta-Lactamase
FBF37_00360	ENOG4105CNU	cell division protein FtsK
FBF37_00370	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
FBF37_00375	ENOG4105Z8H	single-stranded DNA-binding protein
FBF37_00380	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
FBF37_00395	ENOG4105DX0	Hemolysin A
FBF37_00400	ENOG4105C3G	gtp-binding protein
FBF37_00435	ENOG4107QHF	type ii secretion system protein e
FBF37_00440	ENOG4105CZX	twitching motility protein
FBF37_00445	ENOG4105D7Q	type ii secretion system
FBF37_00480	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
FBF37_00485	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
FBF37_00525	ENOG4105C22	threonyL-tRNA synthetase
FBF37_00530	ENOG41080UX	Methyltransferase
FBF37_00535	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
FBF37_00550	ENOG4105KDC	50s ribosomal protein l28
FBF37_00555	ENOG4108Z4T	Peptidase M50
FBF37_00565	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
FBF37_00570	ENOG4105VJV	50s ribosomal protein L35
FBF37_00575	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
FBF37_00580	ENOG4105C0P	Mg chelatase subunit ChlI
FBF37_00615	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
FBF37_00620	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
FBF37_00655	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
FBF37_00685	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
FBF37_00705	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
FBF37_00710	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
FBF37_00715	ENOG4105C25	Primosomal protein n'
FBF37_00730	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
FBF37_00740	ENOG4108BRJ	30S ribosomal protein S21
FBF37_00750	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
FBF37_00755	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
FBF37_00765	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
FBF37_00770	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
FBF37_00775	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
FBF37_00805	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
FBF37_00825	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
FBF37_00830	ENOG4107QJE	Chromosome Partitioning Protein
FBF37_00840	ENOG4105C3F	Signal peptidase i
FBF37_00855	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
FBF37_00865	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
FBF37_00875	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
FBF37_00885	ENOG4105NRA	50s ribosomal protein l31 type b
FBF37_00890	ENOG4105CE9	30S ribosomal protein S2
FBF37_00905	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
FBF37_00920	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
FBF37_00925	ENOG4105DZP	Membrane-associated zinc metalloprotease
FBF37_00935	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
FBF37_00940	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
FBF37_00945	ENOG4105CRK	lysyL-tRNA synthetase
FBF37_00955	ENOG4108JU5	Magnesium and cobalt efflux protein
FBF37_00965	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
FBF37_00970	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
FBF37_00975	ENOG4105K7K	Transcriptional regulator
FBF37_00985	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
FBF37_00990	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
FBF37_00995	ENOG4105MS2	ribosomal subunit Interface protein
FBF37_01020	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
FBF37_01030	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
FBF37_01035	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
FBF37_01045	ENOG4105CAK	Cell division ATP-binding protein ftsE
FBF37_01050	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
FBF37_01055	ENOG41068JE	domain protein
FBF37_01065	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FBF37_01070	ENOG4105K46	50S ribosomal protein l27
FBF37_01075	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
FBF37_01085	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
FBF37_01095	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
FBF37_01110	ENOG4105ETX	regulatoR
FBF37_01115	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
FBF37_01120	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
FBF37_01160	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
FBF37_01175	ENOG4107QUV	Domain protein
FBF37_01185	ENOG4108V6E	Cell division protein mraZ
FBF37_01190	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
FBF37_01200	ENOG4105CJN	penicillin-binding protein
FBF37_01205	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
FBF37_01210	ENOG4105CNI	cell division protein FtsW
FBF37_01215	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
FBF37_01280	ENOG4108UZE	carboxy-peptidase
FBF37_01295	ENOG4105CGK	Exodeoxyribonuclease III
FBF37_01300	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
FBF37_01325	ENOG4105C5H	ABC transporter
FBF37_01370	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
FBF37_01375	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
FBF37_01385	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
FBF37_01390	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
FBF37_01410	ENOG4105C4R	Atp-dependent dna helicase
FBF37_01425	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
FBF37_01430	ENOG4108VAU	general secretion pathway protein G
FBF37_01460	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
FBF37_01465	ENOG4105US7	Histidine kinase
FBF37_01470	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FBF37_01475	ENOG4108IUX	(ABC) transporter
FBF37_01490	ENOG4105C8N	cysteinyl-tRNA synthetase
FBF37_01540	ENOG4105C79	DNA protecting protein DprA
FBF37_01555	ENOG4105CKI	cobalamin synthesis protein
FBF37_01575	ENOG4107QRP	cobalamin biosynthesis protein CobW
FBF37_01585	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
FBF37_01595	ENOG4105I08	Pseudouridine synthase
FBF37_01600	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FBF37_01605	ENOG4105BZU	Histidine kinase
FBF37_01615	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FBF37_01620	ENOG4105GR3	Histidine kinase
FBF37_01625	ENOG4108R5T	secreted protein
FBF37_01630	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
FBF37_01635	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
FBF37_01645	ENOG4105CDU	Replicative dna helicase
FBF37_01650	ENOG4105C6E	dna polymerase iii
FBF37_01675	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
FBF37_01680	ENOG4108VZM	50s ribosomal protein L10
FBF37_01705	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
FBF37_01710	ENOG4107UIY	sua5 ycio yrdc ywlc family protein
FBF37_01720	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
FBF37_01735	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
FBF37_01745	ENOG4105BZU	Histidine kinase
FBF37_01765	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
FBF37_01775	ENOG4105W0E	50S ribosomal protein L33
FBF37_01785	ENOG4108VPT	UPF0234 protein
FBF37_01815	ENOG4107QRG	dna polymerase iii
FBF37_01820	ENOG4105C34	Pseudouridine synthase
FBF37_01825	ENOG4105C31	Tryptophanyl-tRNA synthetase
FBF37_01830	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
FBF37_01840	ENOG4108UJD	30S ribosomal protein S9
FBF37_01845	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
FBF37_01850	ENOG4108ZT0	50S ribosomal protein l17
FBF37_01860	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
FBF37_01865	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
FBF37_01870	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FBF37_01880	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
FBF37_01905	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
FBF37_01915	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
FBF37_01920	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
FBF37_01935	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
FBF37_01940	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FBF37_01945	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
FBF37_01950	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
FBF37_01955	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
FBF37_01960	ENOG41082SA	50s ribosomal protein l29
FBF37_01965	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
FBF37_01970	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
FBF37_01975	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
FBF37_01980	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
FBF37_01985	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FBF37_01990	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
FBF37_01995	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
FBF37_02000	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
FBF37_02010	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
FBF37_02015	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
FBF37_02060	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
FBF37_02070	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
FBF37_02075	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
FBF37_02085	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
FBF37_02090	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
FBF37_02095	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
FBF37_02120	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
FBF37_02130	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
FBF37_02140	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
FBF37_02200	ENOG4105CQB	FAD linked oxidase domain protein
FBF37_02205	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
FBF37_02255	ENOG4105CI3	gtp-binding protein typa
FBF37_02270	ENOG4105D1H	recombination factor protein RarA
FBF37_02280	ENOG4105CG3	alpha amylase, catalytic region
FBF37_02310	ENOG4106H78	methyltransferase
FBF37_02320	ENOG4105CB5	ATP-dependent DNA helicase recG
FBF37_02335	ENOG4105BZ4	penicillin-binding protein
FBF37_02345	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
FBF37_02355	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
FBF37_02365	ENOG4105CHV	Transcription elongation factor NusA
FBF37_02395	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
FBF37_02410	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
FBF37_02425	ENOG4105C6K	Malic enzyme
FBF37_02430	ENOG4107QHF	type ii secretion system protein e
FBF37_02435	ENOG4105C2N	RNA methyltransferase TrmH family group 3
FBF37_02440	ENOG4105C0B	DNA polymerase III (alpha subunit)
FBF37_02455	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
FBF37_02460	ENOG4105Q33	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency
FBF37_02465	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
FBF37_02475	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
FBF37_02480	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
FBF37_02490	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
FBF37_02495	ENOG4105CDH	Citrulline--aspartate ligase
FBF37_02500	ENOG4105CH7	arginosuccinase
FBF37_02505	ENOG4108URH	decarboxylase
FBF37_02515	ENOG4107UH8	sugar kinase
FBF37_02520	ENOG4105D2N	Aldolase
FBF37_02525	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
FBF37_02530	ENOG4108HHA	Transketolase
FBF37_02535	ENOG4105DJV	ribulose-phosphate 3-epimerase
FBF37_02540	ENOG4108YZG	isomerase
FBF37_02555	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
FBF37_02570	ENOG4105BZ1	(ABC) transporter
FBF37_02575	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
FBF37_02645	ENOG4105RHY	Pfam:UPF0157
FBF37_02650	ENOG4105BZU	Histidine kinase
FBF37_02655	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FBF37_02670	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
FBF37_02675	ENOG4107QN2	dihydrolipoyl dehydrogenase
FBF37_02690	ENOG4107RDT	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
FBF37_02720	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
FBF37_02730	ENOG4105VB6	UPF0109 protein
FBF37_02735	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
FBF37_02755	ENOG4105C8T	Leucyl-tRNA synthetase
FBF37_02765	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
FBF37_02790	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
FBF37_02800	ENOG4105D0M	Protease HtpX homolog
FBF37_02805	ENOG4108V0P	LemA family
FBF37_02810	ENOG4105EMU	Dehydrogenase
FBF37_02845	ENOG41082T9	Membrane
FBF37_02855	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
FBF37_02870	ENOG4105K63	Thioredoxin
FBF37_02880	ENOG4105BZ1	(ABC) transporter
FBF37_02890	ENOG4105DQR	SNARE associated Golgi
FBF37_02895	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
FBF37_02905	ENOG4105CJB	Exodeoxyribonuclease I
FBF37_02915	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FBF37_02930	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
FBF37_02940	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
FBF37_02945	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
FBF37_02955	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
FBF37_02965	ENOG4107QI6	Cysteine desulfurase
FBF37_02980	ENOG4105F8V	Hydrolase, tatD family
FBF37_02985	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
FBF37_02995	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
FBF37_03020	ENOG4105CP7	Triose-phosphate isomerase
FBF37_03025	ENOG4105BZA	Phosphoglycerate kinase
FBF37_03035	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
FBF37_03040	ENOG4108JJA	ABC, transporter
FBF37_03070	ENOG4105BZU	Histidine kinase
FBF37_03075	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
FBF37_03080	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
FBF37_03110	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
FBF37_03115	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
FBF37_03140	ENOG4107XGT	Cell wall formation (By similarity)
FBF37_03180	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
FBF37_03185	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
FBF37_03190	ENOG41072GX	Peptidase M22 Glycoprotease
FBF37_03195	ENOG4105K8N	protein family UPF0079, ATPase
FBF37_03200	ENOG4107QHF	type ii secretion system protein e
FBF37_03205	ENOG4105D7Q	type ii secretion system
FBF37_03235	ENOG4105KC9	Modulates RecA activity (By similarity)
FBF37_03245	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
FBF37_03260	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
FBF37_03275	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
FBF37_03280	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
FBF37_03290	ENOG4105CDY	transcriptional regulatory protein
FBF37_03325	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
FBF37_03335	ENOG4108PBA	serine threonine protein kinase
FBF37_03340	ENOG4105CFG	Acts as a chaperone (By similarity)
FBF37_03350	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FBF37_03355	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
FBF37_03365	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
FBF37_03385	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
FBF37_03400	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
FBF37_03410	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
FBF37_03415	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
FBF37_03470	ENOG4105DFU	Cell wall formation (By similarity)
FBF37_03485	ENOG4107T6Z	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
FBF37_03490	ENOG4105D8X	mechanosensitive ion channel
FBF37_03515	ENOG4105CEN	a g-specific adenine glycosylase
FBF37_03530	ENOG4107UQD	Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity)
FBF37_03545	ENOG4105C9M	aspartyl-trna synthetase
FBF37_03555	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
FBF37_03570	ENOG4105CJ1	ABC, transporter
FBF37_03575	ENOG4105D7N	magnesium and cobalt transport protein CorA
FBF37_03580	ENOG4105C5B	carbamate kinase
FBF37_03585	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
FBF37_03590	ENOG4105DBV	ornithine carbamoyltransferase
FBF37_03610	ENOG4108V1U	phospholipid-binding protein
FBF37_03620	ENOG4105BZ1	(ABC) transporter
FBF37_03635	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
FBF37_03655	ENOG4105E5Q	amino acid AbC transporter
FBF37_03660	ENOG4108HW3	(ABC) transporter
FBF37_03665	ENOG4107RES	phosphoglycerol transferase I
FBF37_03670	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
FBF37_03680	ENOG4107XPZ	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
FBF37_03700	ENOG4108ZJ4	polysaccharide deacetylase
FBF37_03745	ENOG4105C0D	helicase
FBF37_03750	ENOG4105W5Q	DNA repair protein (RadC
FBF37_03770	ENOG4105EWK	phytoene
FBF37_03795	ENOG4108EGH	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
FBF37_03805	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
FBF37_03825	ENOG4105CIG	ABC transporter
FBF37_03830	ENOG41062D9	Histidine kinase
FBF37_03860	ENOG4108PJD	permease
FBF37_03870	ENOG4105EDW	glycosyl transferase, family 39
FBF37_03900	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
FBF37_03905	ENOG4105CMR	udp-glucose 4-epimerase
FBF37_03925	ENOG4105D3Q	Sugar transferase
FBF37_03930	ENOG4107QJZ	Glycosyl transferase, family 2
FBF37_03935	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
FBF37_03940	ENOG4107VIJ	nudix hydrolase
FBF37_03955	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
FBF37_03960	ENOG4105CKK	Glycosyl transferase, family 2
FBF37_04020	ENOG4105EY8	ABC transporter
FBF37_04035	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins