locus-tag	class	description
TF3313_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TF3313_0003	COG0335	large ribosomal subunit rRNA binding
TF3313_0008	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TF3313_0011	COG3590	peptidase
TF3313_0016	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TF3313_0017	COG1120	ATPase activity
TF3313_0020	COG0543	2 iron, 2 sulfur cluster binding
TF3313_0021	COG0167	dihydroorotate dehydrogenase activity
TF3313_0024	COG1285	pathogenesis
TF3313_0026	COG0101	tRNA pseudouridine synthase activity
TF3313_0028	COG1797	cobyrinic acid a,c-diamide synthase activity
TF3313_0030	COG5297	Belongs to the glycosyl hydrolase family 6
TF3313_0030	COG3250	beta-galactosidase activity
TF3313_0032	COG4206	TonB-dependent receptor
TF3313_0032	COG1629	transport
TF3313_0035	COG4206	TonB-dependent receptor
TF3313_0035	COG1629	transport
TF3313_0038	COG1215	transferase activity, transferring glycosyl groups
TF3313_0040	COG2385	sporulation resulting in formation of a cellular spore
TF3313_0040	COG2247	cell wall binding repeat
TF3313_0041	COG2211	Major facilitator Superfamily
TF3313_0042	COG3876	Protein conserved in bacteria
TF3313_0045	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TF3313_0046	COG0561	phosphatase activity
TF3313_0062	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TF3313_0065	COG3385	transposase activity
TF3313_0071	COG2274	protein secretion by the type I secretion system
TF3313_0075	COG0438	transferase activity, transferring glycosyl groups
TF3313_0084	COG2274	protein secretion by the type I secretion system
TF3313_0091	COG1187	pseudouridine synthase activity
TF3313_0096	COG1132	(ABC) transporter
TF3313_0097	COG1132	(ABC) transporter
TF3313_0099	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
TF3313_0102	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TF3313_0110	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TF3313_0111	COG0543	2 iron, 2 sulfur cluster binding
TF3313_0112	COG0493	'glutamate synthase
TF3313_0113	COG3015	lipoprotein NlpE involved in copper resistance
TF3313_0115	COG1051	belongs to the nudix hydrolase family
TF3313_0116	COG1970	mechanosensitive ion channel activity
TF3313_0117	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TF3313_0119	COG2972	Histidine kinase
TF3313_0119	COG0745	RESPONSE REGULATOR receiver
TF3313_0122	COG4591	ABC-type transport system involved in lipoprotein release permease component
TF3313_0122	COG1136	(ABC) transporter
TF3313_0133	COG4191	Histidine kinase
TF3313_0139	COG0438	transferase activity, transferring glycosyl groups
TF3313_0142	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TF3313_0145	COG0237	dephospho-CoA kinase activity
TF3313_0147	COG1862	Preprotein translocase
TF3313_0148	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TF3313_0150	COG0252	asparaginase activity
TF3313_0154	COG1629	transport
TF3313_0154	COG4206	TonB-dependent receptor
TF3313_0159	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TF3313_0162	COG1011	Hydrolase
TF3313_0164	COG1595	DNA-templated transcription, initiation
TF3313_0180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TF3313_0182	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TF3313_0183	COG0235	Class ii aldolase
TF3313_0185	COG4806	L-rhamnose isomerase
TF3313_0186	COG1070	Carbohydrate kinase
TF3313_0189	COG0442	prolyl-tRNA aminoacylation
TF3313_0190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TF3313_0193	COG1704	LemA family
TF3313_0194	COG0501	Belongs to the peptidase M48B family
TF3313_0195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TF3313_0196	COG0126	phosphoglycerate kinase activity
TF3313_0197	COG0534	Mate efflux family protein
TF3313_0205	COG0484	heat shock protein binding
TF3313_0206	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TF3313_0207	COG1193	negative regulation of DNA recombination
TF3313_0209	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TF3313_0211	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TF3313_0217	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TF3313_0219	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TF3313_0222	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TF3313_0223	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TF3313_0226	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TF3313_0230	COG2264	protein methyltransferase activity
TF3313_0233	COG1373	ATPase (AAA superfamily
TF3313_0234	COG4804	nuclease activity
TF3313_0242	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TF3313_0244	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TF3313_0245	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TF3313_0251	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
TF3313_0252	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TF3313_0257	COG3250	beta-galactosidase activity
TF3313_0259	COG2431	L-lysine efflux transmembrane transporter activity
TF3313_0260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TF3313_0261	COG3339	Conserved Protein
TF3313_0264	COG0738	Major facilitator superfamily
TF3313_0265	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TF3313_0265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TF3313_0266	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TF3313_0268	COG2885	chlorophyll binding
TF3313_0269	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TF3313_0269	COG1333	cytochrome c biogenesis protein
TF3313_0270	COG0823	Involved in the tonB-independent uptake of proteins
TF3313_0270	COG1506	peptidase
TF3313_0272	COG3537	Alpha-1,2-mannosidase
TF3313_0274	COG0534	Mate efflux family protein
TF3313_0275	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TF3313_0276	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TF3313_0277	COG0297	glycogen (starch) synthase activity
TF3313_0305	COG0681	Belongs to the peptidase S26 family
TF3313_0313	COG0681	Belongs to the peptidase S26 family
TF3313_0315	COG0463	Glycosyl transferase, family 2
TF3313_0315	COG1216	Glycosyl transferase, family 2
TF3313_0316	COG3591	Belongs to the peptidase S1B family
TF3313_0319	COG2255	four-way junction helicase activity
TF3313_0331	COG2860	membrane
TF3313_0333	COG1629	transport
TF3313_0333	COG4206	TonB-dependent receptor
TF3313_0335	COG1610	YqeY-like protein
TF3313_0336	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TF3313_0339	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TF3313_0340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TF3313_0341	COG0772	Belongs to the SEDS family
TF3313_0342	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TF3313_0343	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TF3313_0344	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TF3313_0345	COG0768	penicillin binding
TF3313_0347	COG0275	rRNA processing
TF3313_0350	COG0698	ribose 5-phosphate isomerase
TF3313_0351	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TF3313_0352	COG0427	acetyl-CoA hydrolase
TF3313_0353	COG0546	phosphoglycolate phosphatase activity
TF3313_0363	COG1595	DNA-templated transcription, initiation
TF3313_0365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TF3313_0366	COG0658	competence protein
TF3313_0366	COG2333	competence protein COMEC
TF3313_0368	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TF3313_0369	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TF3313_0376	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TF3313_0376	COG0519	Catalyzes the synthesis of GMP from XMP
TF3313_0379	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TF3313_0380	COG0534	Mate efflux family protein
TF3313_0381	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TF3313_0385	COG0312	modulator of DNA gyrase
TF3313_0387	COG3250	beta-galactosidase activity
TF3313_0388	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TF3313_0393	COG0363	glucosamine-6-phosphate deaminase activity
TF3313_0399	COG1136	(ABC) transporter
TF3313_0399	COG0577	efflux transmembrane transporter activity
TF3313_0400	COG1136	(ABC) transporter
TF3313_0403	COG4974	Belongs to the 'phage' integrase family
TF3313_0407	COG3645	SOS response
TF3313_0408	COG0693	protein deglycase activity
TF3313_0411	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TF3313_0411	COG2207	Transcriptional regulator
TF3313_0416	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TF3313_0426	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TF3313_0430	COG4953	penicillin-binding protein 1C
TF3313_0431	COG2373	Large extracellular alpha-helical protein
TF3313_0433	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TF3313_0435	COG0165	Argininosuccinate lyase
TF3313_0440	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
TF3313_0442	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TF3313_0444	COG1160	GTP binding
TF3313_0446	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TF3313_0447	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TF3313_0451	COG3537	Alpha-1,2-mannosidase
TF3313_0456	COG4206	TonB-dependent receptor
TF3313_0456	COG1629	transport
TF3313_0458	COG0823	Involved in the tonB-independent uptake of proteins
TF3313_0458	COG1506	peptidase
TF3313_0458	COG4946	Tricorn protease homolog
TF3313_0460	COG4206	TonB-dependent receptor
TF3313_0460	COG1629	transport
TF3313_0467	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TF3313_0468	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TF3313_0472	COG0180	Tryptophanyl-tRNA synthetase
TF3313_0475	COG0039	L-malate dehydrogenase activity
TF3313_0477	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TF3313_0478	COG0569	domain protein
TF3313_0479	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TF3313_0481	COG4206	TonB-dependent receptor
TF3313_0494	COG1396	sequence-specific DNA binding
TF3313_0496	COG3550	peptidyl-serine autophosphorylation
TF3313_0497	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TF3313_0499	COG0556	nucleotide-excision repair
TF3313_0501	COG3142	Participates in the control of copper homeostasis
TF3313_0507	COG0535	radical SAM domain protein
TF3313_0510	COG3475	LICD family
TF3313_0512	COG0584	glycerophosphoryl diester phosphodiesterase
TF3313_0515	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TF3313_0519	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TF3313_0523	COG4585	Histidine kinase
TF3313_0524	COG2197	response regulator
TF3313_0526	COG2852	Protein conserved in bacteria
TF3313_0535	COG0084	hydrolase, TatD family'
TF3313_0536	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TF3313_0537	COG0594	ribonuclease P activity
TF3313_0540	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TF3313_0543	COG1629	transport
TF3313_0543	COG4206	TonB-dependent receptor
TF3313_0546	COG0659	secondary active sulfate transmembrane transporter activity
TF3313_0605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TF3313_0607	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TF3313_0608	COG0793	Belongs to the peptidase S41A family
TF3313_0610	COG0194	GDP metabolic process
TF3313_0611	COG1561	YicC-like family, N-terminal region
TF3313_0617	COG1022	Amp-dependent synthetase and ligase
TF3313_0618	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TF3313_0620	COG1215	transferase activity, transferring glycosyl groups
TF3313_0626	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TF3313_0627	COG0792	nuclease activity
TF3313_0631	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TF3313_0632	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TF3313_0633	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TF3313_0634	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TF3313_0635	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TF3313_0636	COG0356	it plays a direct role in the translocation of protons across the membrane
TF3313_0638	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TF3313_0639	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TF3313_0641	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TF3313_0642	COG1091	dTDP-4-dehydrorhamnose reductase activity
TF3313_0645	COG0612	Peptidase, M16
TF3313_0647	COG1696	Membrane protein involved in D-alanine export
TF3313_0651	COG0443	Heat shock 70 kDa protein
TF3313_0681	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TF3313_0682	COG3386	PFAM SMP-30 Gluconolaconase
TF3313_0688	COG0778	Nitroreductase
TF3313_0688	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
TF3313_0692	COG2884	Cell division ATP-binding protein ftsE
TF3313_0693	COG0527	aspartate kinase activity
TF3313_0694	COG0019	diaminopimelate decarboxylase activity
TF3313_0698	COG0673	inositol 2-dehydrogenase activity
TF3313_0699	COG1629	transport
TF3313_0699	COG4206	TonB-dependent receptor
TF3313_0701	COG3119	arylsulfatase activity
TF3313_0707	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TF3313_0709	COG2986	histidine ammonia-lyase
TF3313_0714	COG4206	TonB-dependent receptor
TF3313_0720	COG0793	Belongs to the peptidase S41A family
TF3313_0722	COG1192	Involved in chromosome partitioning
TF3313_0723	COG1475	DNA binding
TF3313_0725	COG3942	CHAP domain
TF3313_0725	COG1388	LysM domain
TF3313_0726	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TF3313_0732	COG0739	heme binding
TF3313_0733	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TF3313_0734	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TF3313_0736	COG3119	arylsulfatase activity
TF3313_0739	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TF3313_0742	COG4676	Protein conserved in bacteria
TF3313_0744	COG1228	amidohydrolase
TF3313_0746	COG3404	Formiminotransferase-cyclodeaminase
TF3313_0747	COG2986	histidine ammonia-lyase
TF3313_0750	COG2996	Protein conserved in bacteria
TF3313_0757	COG1136	(ABC) transporter
TF3313_0758	COG0733	neurotransmitter:sodium symporter activity
TF3313_0761	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TF3313_0770	COG0758	DNA mediated transformation
TF3313_0771	COG2194	sulfuric ester hydrolase activity
TF3313_0773	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TF3313_0774	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TF3313_0774	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TF3313_0786	COG1482	cell wall glycoprotein biosynthetic process
TF3313_0787	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TF3313_0790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TF3313_0791	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TF3313_0793	COG0066	3-isopropylmalate dehydratase activity
TF3313_0794	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TF3313_0795	COG0473	3-isopropylmalate dehydrogenase activity
TF3313_0799	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TF3313_0804	COG0475	glutathione-regulated potassium exporter activity
TF3313_0806	COG0826	peptidase U32
TF3313_0807	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TF3313_0808	COG1058	Belongs to the CinA family
TF3313_0808	COG1546	Belongs to the CinA family
TF3313_0809	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TF3313_0813	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TF3313_0814	COG0540	Belongs to the ATCase OTCase family
TF3313_0836	COG0745	RESPONSE REGULATOR receiver
TF3313_0842	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TF3313_0843	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TF3313_0847	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TF3313_0848	COG1373	ATPase (AAA superfamily
TF3313_0852	COG0560	Phosphoserine phosphatase
TF3313_0858	COG1595	DNA-templated transcription, initiation
TF3313_0861	COG2204	response regulator
TF3313_0862	COG0802	atpase or kinase
TF3313_0864	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TF3313_0864	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TF3313_0875	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TF3313_0877	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TF3313_0878	COG2715	membrane protein required for spore maturation
TF3313_0879	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TF3313_0881	COG0495	leucyl-tRNA aminoacylation
TF3313_0882	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TF3313_0883	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TF3313_0886	COG1022	Amp-dependent synthetase and ligase
TF3313_0887	COG1280	lysine exporter protein (LysE YggA)
TF3313_0889	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TF3313_0890	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TF3313_0894	COG0084	hydrolase, TatD family'
TF3313_0896	COG0811	peptide transport
TF3313_0901	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TF3313_0902	COG0511	ligase activity, forming carbon-carbon bonds
TF3313_0906	COG1629	transport
TF3313_0906	COG4206	TonB-dependent receptor
TF3313_0907	COG0561	phosphatase activity
TF3313_0909	COG1482	cell wall glycoprotein biosynthetic process
TF3313_0910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TF3313_0926	COG0420	3'-5' exonuclease activity
TF3313_0928	COG1940	carbohydrate kinase activity
TF3313_0929	COG1703	isobutyryl-CoA mutase activity
TF3313_0932	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TF3313_0933	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TF3313_0935	COG2233	PERMEase
TF3313_0936	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TF3313_0937	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TF3313_0937	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TF3313_0938	COG0142	geranyltranstransferase activity
TF3313_0941	COG0726	polysaccharide deacetylase
TF3313_0942	COG1506	peptidase
TF3313_0942	COG0823	Involved in the tonB-independent uptake of proteins
TF3313_0946	COG4948	Mandelate Racemase Muconate Lactonizing
TF3313_0949	COG0731	radical SAM domain protein
TF3313_0949	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TF3313_0957	COG1629	transport
TF3313_0957	COG4206	TonB-dependent receptor
TF3313_0959	COG2814	Major facilitator Superfamily
TF3313_0965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TF3313_0967	COG0517	IMP dehydrogenase activity
TF3313_0967	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TF3313_0968	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TF3313_0970	COG2195	Cleaves the N-terminal amino acid of tripeptides
TF3313_0971	COG1185	polyribonucleotide nucleotidyltransferase activity
TF3313_0976	COG0438	transferase activity, transferring glycosyl groups
TF3313_0978	COG0438	transferase activity, transferring glycosyl groups
TF3313_0980	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TF3313_0981	COG3177	Filamentation induced by cAMP protein fic
TF3313_0985	COG0367	asparagine synthase
TF3313_0991	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TF3313_0993	COG1083	cytidylyl-transferase
TF3313_0995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TF3313_0996	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TF3313_0997	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TF3313_0998	COG2089	acid synthase
TF3313_1000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TF3313_1000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TF3313_1002	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TF3313_1003	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TF3313_1004	COG2244	polysaccharide biosynthetic process
TF3313_1006	COG0673	inositol 2-dehydrogenase activity
TF3313_1008	COG0793	Belongs to the peptidase S41A family
TF3313_1008	COG3409	Peptidoglycan-binding domain 1 protein
TF3313_1009	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TF3313_1017	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TF3313_1018	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TF3313_1019	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TF3313_1020	COG0571	ribonuclease III activity
TF3313_1023	COG0205	6-phosphofructokinase activity
TF3313_1024	COG0737	Belongs to the 5'-nucleotidase family
TF3313_1027	COG0445	tRNA wobble uridine modification
TF3313_1028	COG0322	excinuclease ABC activity
TF3313_1029	COG1490	D-aminoacyl-tRNA deacylase activity
TF3313_1031	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TF3313_1031	COG5549	protein import
TF3313_1035	COG5549	protein import
TF3313_1035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TF3313_1036	COG5549	protein import
TF3313_1036	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TF3313_1038	COG1234	tRNA 3'-trailer cleavage
TF3313_1041	COG0509	glycine decarboxylation via glycine cleavage system
TF3313_1042	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TF3313_1043	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TF3313_1049	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TF3313_1051	COG2204	response regulator
TF3313_1057	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TF3313_1059	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TF3313_1061	COG2076	Multidrug Resistance protein
TF3313_1063	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TF3313_1069	COG1944	ATP diphosphatase activity
TF3313_1076	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TF3313_1077	COG3119	arylsulfatase activity
TF3313_1079	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TF3313_1082	COG1904	glucuronate isomerase
TF3313_1083	COG0205	6-phosphofructokinase activity
TF3313_1092	COG0714	Associated with various cellular activities
TF3313_1095	COG5549	protein import
TF3313_1095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TF3313_1105	COG2095	MarC family integral membrane protein
TF3313_1107	COG0151	Belongs to the GarS family
TF3313_1113	COG2706	6-phosphogluconolactonase activity
TF3313_1118	COG1755	Isoprenylcysteine carboxyl methyltransferase
TF3313_1119	COG1629	transport
TF3313_1119	COG4206	TonB-dependent receptor
TF3313_1120	COG0561	phosphatase activity
TF3313_1130	COG1629	transport
TF3313_1130	COG4206	TonB-dependent receptor
TF3313_1134	COG2197	response regulator
TF3313_1137	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TF3313_1141	COG0423	glycine-tRNA ligase activity
TF3313_1144	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TF3313_1144	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TF3313_1166	COG1629	transport
TF3313_1166	COG4206	TonB-dependent receptor
TF3313_1169	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TF3313_1169	COG2885	chlorophyll binding
TF3313_1170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TF3313_1173	COG5434	Belongs to the glycosyl hydrolase 28 family
TF3313_1175	COG1028	Short-chain dehydrogenase reductase Sdr
TF3313_1176	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TF3313_1182	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TF3313_1185	COG2096	Adenosyltransferase
TF3313_1188	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TF3313_1194	COG0681	Belongs to the peptidase S26 family
TF3313_1195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TF3313_1203	COG0233	cytoplasmic translational termination
TF3313_1204	COG1162	GTPase activity
TF3313_1205	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TF3313_1206	COG1629	transport
TF3313_1206	COG4206	TonB-dependent receptor
TF3313_1209	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TF3313_1210	COG0280	phosphate acetyltransferase
TF3313_1211	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TF3313_1212	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TF3313_1213	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TF3313_1216	COG0826	peptidase U32
TF3313_1238	COG0582	viral genome integration into host DNA
TF3313_1239	COG4974	Belongs to the 'phage' integrase family
TF3313_1246	COG1012	belongs to the aldehyde dehydrogenase family
TF3313_1247	COG0813	purine-nucleoside phosphorylase activity
TF3313_1249	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TF3313_1251	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TF3313_1252	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TF3313_1252	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TF3313_1253	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TF3313_1255	COG0284	orotidine-5'-phosphate decarboxylase activity
TF3313_1256	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TF3313_1257	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TF3313_1262	COG3956	TIGRFAM MazG family protein
TF3313_1263	COG3250	beta-galactosidase activity
TF3313_1270	COG4974	Belongs to the 'phage' integrase family
TF3313_1272	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TF3313_1273	COG0598	Magnesium transport protein CorA
TF3313_1274	COG0606	chelatase, subunit chli
TF3313_1279	COG1629	transport
TF3313_1279	COG4206	TonB-dependent receptor
TF3313_1282	COG0463	Glycosyl transferase, family 2
TF3313_1287	COG4206	TonB-dependent receptor
TF3313_1287	COG1629	transport
TF3313_1292	COG1629	transport
TF3313_1292	COG4206	TonB-dependent receptor
TF3313_1294	COG0012	GTP binding
TF3313_1309	COG2003	Belongs to the UPF0758 family
TF3313_1310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TF3313_1314	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TF3313_1318	COG2890	protein-(glutamine-N5) methyltransferase activity
TF3313_1319	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TF3313_1319	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TF3313_1322	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TF3313_1326	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TF3313_1329	COG1121	(ABC) transporter
TF3313_1330	COG4591	ABC-type transport system involved in lipoprotein release permease component
TF3313_1331	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TF3313_1334	COG1629	transport
TF3313_1334	COG4206	TonB-dependent receptor
TF3313_1339	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TF3313_1345	COG1956	GAF domain-containing protein
TF3313_1346	COG0617	tRNA 3'-terminal CCA addition
TF3313_1347	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TF3313_1355	COG0427	acetyl-CoA hydrolase
TF3313_1356	COG1454	alcohol dehydrogenase
TF3313_1357	COG1012	belongs to the aldehyde dehydrogenase family
TF3313_1358	COG1960	acyl-CoA dehydrogenase activity
TF3313_1359	COG2086	electron transfer activity
TF3313_1360	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TF3313_1362	COG1137	ATPase activity
TF3313_1363	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TF3313_1366	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TF3313_1368	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TF3313_1369	COG0514	ATP-dependent DNA helicase (RecQ)
TF3313_1370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TF3313_1371	COG0740	serine-type endopeptidase activity
TF3313_1372	COG0544	peptidyl-prolyl cis-trans isomerase activity
TF3313_1379	COG4206	TonB-dependent receptor
TF3313_1380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TF3313_1384	COG0756	dUTP diphosphatase activity
TF3313_1388	COG1629	transport
TF3313_1388	COG4206	TonB-dependent receptor
TF3313_1391	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TF3313_1395	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TF3313_1397	COG0124	histidyl-tRNA synthetase
TF3313_1398	COG1404	Belongs to the peptidase S8 family
TF3313_1402	COG0551	DNA topoisomerase type I activity
TF3313_1402	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TF3313_1403	COG1595	DNA-templated transcription, initiation
TF3313_1406	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TF3313_1408	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TF3313_1409	COG0049	tRNA binding
TF3313_1410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TF3313_1411	COG0051	transcription antitermination factor activity, RNA binding
TF3313_1412	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TF3313_1413	COG0088	Forms part of the polypeptide exit tunnel
TF3313_1414	COG0089	rRNA binding
TF3313_1415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TF3313_1416	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TF3313_1418	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TF3313_1419	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TF3313_1420	COG0255	Belongs to the universal ribosomal protein uL29 family
TF3313_1421	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TF3313_1422	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TF3313_1423	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TF3313_1424	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TF3313_1425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TF3313_1426	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TF3313_1427	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TF3313_1428	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TF3313_1429	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TF3313_1430	COG1841	ribosomal large subunit assembly
TF3313_1431	COG0200	Binds to the 23S rRNA
TF3313_1432	COG0201	protein transport
TF3313_1434	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TF3313_1435	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TF3313_1436	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TF3313_1437	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TF3313_1438	COG0202	RNA polymerase activity
TF3313_1439	COG0203	ribosomal protein L17
TF3313_1440	COG1127	ABC transporter
TF3313_1441	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TF3313_1445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TF3313_1446	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TF3313_1454	COG0366	Alpha amylase catalytic
TF3313_1455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TF3313_1457	COG0482	sulfurtransferase activity
TF3313_1460	COG4771	TonB-dependent receptor
TF3313_1473	COG0428	transporter
TF3313_1475	COG2226	methyltransferase
TF3313_1476	COG2226	methyltransferase
TF3313_1479	COG2226	methyltransferase
TF3313_1483	COG1132	(ABC) transporter
TF3313_1485	COG1132	(ABC) transporter
TF3313_1486	COG2066	Belongs to the glutaminase family
TF3313_1490	COG0196	riboflavin kinase activity
TF3313_1495	COG5492	domain, Protein
TF3313_1496	COG0641	radical SAM
TF3313_1498	COG1053	succinate dehydrogenase
TF3313_1500	COG0018	arginyl-trna synthetase
TF3313_1502	COG0525	valine-tRNA ligase activity
TF3313_1511	COG1242	4 iron, 4 sulfur cluster binding
TF3313_1515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TF3313_1520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TF3313_1520	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TF3313_1524	COG0779	Required for maturation of 30S ribosomal subunits
TF3313_1525	COG0195	Participates in both transcription termination and antitermination
TF3313_1525	COG2251	uridine kinase activity
TF3313_1526	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TF3313_1528	COG0719	Fe-S assembly protein
TF3313_1529	COG0396	ATPase activity
TF3313_1530	COG0719	Fe-S assembly protein
TF3313_1534	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TF3313_1535	COG0436	Aminotransferase
TF3313_1541	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TF3313_1544	COG0393	Putative heavy-metal-binding
TF3313_1545	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TF3313_1546	COG2166	iron-sulfur cluster assembly
TF3313_1548	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TF3313_1549	COG0187	DNA topoisomerase II activity
TF3313_1551	COG2274	protein secretion by the type I secretion system
TF3313_1558	COG0463	Glycosyl transferase, family 2
TF3313_1558	COG1216	Glycosyl transferase, family 2
TF3313_1567	COG0268	Binds directly to 16S ribosomal RNA
TF3313_1570	COG4206	TonB-dependent receptor
TF3313_1570	COG1629	transport
TF3313_1572	COG1629	transport
TF3313_1572	COG4206	TonB-dependent receptor
TF3313_1574	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TF3313_1576	COG3118	belongs to the thioredoxin family
TF3313_1586	COG0514	ATP-dependent DNA helicase (RecQ)
TF3313_1587	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TF3313_1587	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TF3313_1590	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TF3313_1593	COG1253	flavin adenine dinucleotide binding
TF3313_1594	COG1760	l-serine dehydratase
TF3313_1595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TF3313_1596	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TF3313_1597	COG0612	Peptidase, M16
TF3313_1604	COG1940	carbohydrate kinase activity
TF3313_1611	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TF3313_1612	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TF3313_1612	COG0674	pyruvate-flavodoxin oxidoreductase activity
TF3313_1613	COG1013	pyruvate-flavodoxin oxidoreductase activity
TF3313_1614	COG2177	Part of the ABC transporter FtsEX involved in
TF3313_1616	COG1968	undecaprenyl-diphosphatase activity
TF3313_1617	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TF3313_1618	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TF3313_1619	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TF3313_1630	COG1595	DNA-templated transcription, initiation
TF3313_1632	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TF3313_1633	COG1151	hydroxylamine reductase activity
TF3313_1636	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TF3313_1642	COG1271	oxidase subunit
TF3313_1644	COG1595	DNA-templated transcription, initiation
TF3313_1646	COG1629	transport
TF3313_1646	COG4206	TonB-dependent receptor
TF3313_1649	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TF3313_1653	COG0363	glucosamine-6-phosphate deaminase activity
TF3313_1655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TF3313_1655	COG0426	domain, Protein
TF3313_1656	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TF3313_1657	COG0673	inositol 2-dehydrogenase activity
TF3313_1659	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TF3313_1660	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TF3313_1661	COG0137	argininosuccinate synthase activity
TF3313_1663	COG1438	arginine binding
TF3313_1667	COG2211	Major facilitator Superfamily
TF3313_1669	COG1032	radical SAM domain protein
TF3313_1672	COG1131	(ABC) transporter
TF3313_1675	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TF3313_1676	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TF3313_1677	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TF3313_1678	COG0742	ribosomal rna small subunit methyltransferase
TF3313_1684	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TF3313_1686	COG1011	Hydrolase
TF3313_1689	COG1492	cobalamin metabolic process
TF3313_1690	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TF3313_1691	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TF3313_1692	COG0251	oxidation-reduction process
TF3313_1694	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TF3313_1695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TF3313_1699	COG3209	COG3209 Rhs family protein
TF3313_1702	COG3209	COG3209 Rhs family protein
TF3313_1716	COG0336	Belongs to the RNA methyltransferase TrmD family
TF3313_1718	COG0072	phenylalanine-tRNA ligase activity
TF3313_1718	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TF3313_1719	COG0217	transcriptional regulatory protein
TF3313_1725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TF3313_1726	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TF3313_1727	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TF3313_1728	COG0791	NLP P60 protein
TF3313_1729	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TF3313_1730	COG1408	metallophosphoesterase
TF3313_1737	COG4139	cobalamin transport
TF3313_1741	COG0632	four-way junction helicase activity
TF3313_1744	COG1074	ATP-dependent DNA helicase activity
TF3313_1745	COG0688	phosphatidylethanolamine metabolic process
TF3313_1746	COG1183	phosphatidylcholine synthase activity
TF3313_1748	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TF3313_1757	COG0737	Belongs to the 5'-nucleotidase family
TF3313_1766	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TF3313_1767	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TF3313_1770	COG1381	Involved in DNA repair and RecF pathway recombination
TF3313_1773	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TF3313_1775	COG2843	Capsule synthesis protein
TF3313_1776	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TF3313_1777	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TF3313_1778	COG4974	Belongs to the 'phage' integrase family
TF3313_1784	COG0250	Participates in transcription elongation, termination and antitermination
TF3313_1785	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TF3313_1786	COG0081	regulation of translation
TF3313_1787	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TF3313_1788	COG0222	ribosome binding
TF3313_1789	COG0085	RNA polymerase activity
TF3313_1790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TF3313_1791	COG0433	COG0433 Predicted ATPase
TF3313_1795	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TF3313_1796	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TF3313_1797	COG4948	Mandelate Racemase Muconate Lactonizing
TF3313_1800	COG4974	Belongs to the 'phage' integrase family
TF3313_1804	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TF3313_1805	COG4804	nuclease activity
TF3313_1806	COG0732	type I restriction modification DNA specificity domain
TF3313_1820	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TF3313_1830	COG1216	Glycosyl transferase, family 2
TF3313_1834	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TF3313_1852	COG4206	TonB-dependent receptor
TF3313_1852	COG1629	transport
TF3313_1855	COG4221	oxidoreductase activity
TF3313_1858	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TF3313_1860	COG1368	sulfuric ester hydrolase activity
TF3313_1861	COG1047	Peptidyl-prolyl cis-trans
TF3313_1862	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TF3313_1863	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TF3313_1866	COG0750	zinc metalloprotease
TF3313_1868	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TF3313_1869	COG4942	peptidase
TF3313_1870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TF3313_1873	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TF3313_1874	COG2183	response to ionizing radiation
TF3313_1881	COG0516	GMP reductase activity
TF3313_1883	COG3275	phosphorelay sensor kinase activity
TF3313_1884	COG3279	Response regulator of the LytR AlgR family
TF3313_1896	COG4974	Belongs to the 'phage' integrase family
TF3313_1897	COG0582	viral genome integration into host DNA
TF3313_1901	COG0148	phosphopyruvate hydratase activity
TF3313_1903	COG0716	FMN binding
TF3313_1908	COG4771	TonB-dependent receptor
TF3313_1909	COG4771	TonB-dependent receptor
TF3313_1913	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TF3313_1914	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TF3313_1918	COG3876	Protein conserved in bacteria
TF3313_1921	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TF3313_1922	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TF3313_1931	COG1629	transport
TF3313_1931	COG4206	TonB-dependent receptor
TF3313_1936	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TF3313_1936	COG4651	solute:proton antiporter activity
TF3313_1938	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TF3313_1943	COG1418	mRNA catabolic process
TF3313_1944	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TF3313_1945	COG0488	(ABC) transporter
TF3313_1949	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TF3313_1958	COG3876	Protein conserved in bacteria
TF3313_1960	COG2871	sodium ion transport
TF3313_1961	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TF3313_1962	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TF3313_1964	COG1805	sodium ion transport
TF3313_1965	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TF3313_1967	COG0739	heme binding
TF3313_1968	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TF3313_1969	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TF3313_1970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TF3313_1971	COG0563	adenylate kinase activity
TF3313_1973	COG3845	ABC transporter
TF3313_1975	COG0346	lactoylglutathione lyase activity
TF3313_1978	COG0463	Glycosyl transferase, family 2
TF3313_1980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TF3313_1981	COG4452	Inner membrane protein CreD
TF3313_1991	COG1028	Short-chain dehydrogenase reductase Sdr
TF3313_1992	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TF3313_1997	COG2885	chlorophyll binding
TF3313_1999	COG0542	response to heat
TF3313_2002	COG5002	protein histidine kinase activity
TF3313_2012	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TF3313_2014	COG2271	Major facilitator Superfamily
TF3313_2015	COG4206	TonB-dependent receptor
TF3313_2015	COG1629	transport
TF3313_2022	COG4822	anaerobic cobalamin biosynthetic process
TF3313_2025	COG4771	TonB-dependent receptor
TF3313_2027	COG1477	protein flavinylation
TF3313_2032	COG1480	7TM receptor with intracellular HD hydrolase
TF3313_2064	COG1072	(Pantothenic acid kinase))
TF3313_2067	COG1131	(ABC) transporter
TF3313_2068	COG0842	Transport permease protein
TF3313_2073	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TF3313_2074	COG4206	TonB-dependent receptor
TF3313_2074	COG1629	transport
TF3313_2075	COG1082	Xylose isomerase domain protein TIM barrel
TF3313_2077	COG0343	queuine tRNA-ribosyltransferase activity
TF3313_2080	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TF3313_2082	COG1773	rubredoxin
TF3313_2083	COG0583	DNA-binding transcription factor activity
TF3313_2085	COG0668	transmembrane transport
TF3313_2086	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TF3313_2088	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
TF3313_2089	COG1629	transport
TF3313_2089	COG4206	TonB-dependent receptor
TF3313_2091	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TF3313_2093	COG3119	arylsulfatase activity
TF3313_2096	COG1028	Short-chain dehydrogenase reductase Sdr
TF3313_2098	COG2271	Major facilitator Superfamily
TF3313_2115	COG1570	exodeoxyribonuclease VII activity
TF3313_2118	COG2502	aspartate--ammonia ligase
TF3313_2120	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TF3313_2120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TF3313_2121	COG1752	Esterase of the alpha-beta hydrolase superfamily
TF3313_2123	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TF3313_2134	COG3177	Filamentation induced by cAMP protein fic
TF3313_2137	COG1353	crispr-associated protein
TF3313_2139	COG1337	RAMP superfamily
TF3313_2155	COG3617	BRO family, N-terminal domain
TF3313_2167	COG1518	maintenance of DNA repeat elements
TF3313_2168	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TF3313_2172	COG1528	Iron-storage protein
TF3313_2173	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TF3313_2177	COG0776	regulation of translation
TF3313_2178	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TF3313_2180	COG1640	4-alpha-glucanotransferase
TF3313_2184	COG4589	Belongs to the CDS family
TF3313_2185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TF3313_2186	COG0799	negative regulation of ribosome biogenesis
TF3313_2196	COG0285	dihydrofolate synthase activity
TF3313_2197	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TF3313_2199	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TF3313_2209	COG0497	DNA recombination
TF3313_2210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TF3313_2211	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TF3313_2212	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TF3313_2213	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TF3313_2214	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TF3313_2216	COG2195	Cleaves the N-terminal amino acid of tripeptides
TF3313_2219	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TF3313_2220	COG1979	alcohol dehydrogenase
TF3313_2225	COG3250	beta-galactosidase activity
TF3313_2226	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TF3313_2229	COG0470	DNA polymerase III
TF3313_2230	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TF3313_2232	COG0534	Mate efflux family protein
TF3313_2234	COG4206	TonB-dependent receptor
TF3313_2234	COG1629	transport
TF3313_2241	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TF3313_2242	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TF3313_2243	COG1748	Saccharopine dehydrogenase
TF3313_2246	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TF3313_2247	COG1216	Glycosyl transferase, family 2
TF3313_2270	COG4206	TonB-dependent receptor
TF3313_2270	COG1629	transport
TF3313_2277	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TF3313_2280	COG0739	heme binding
TF3313_2283	COG0149	triose-phosphate isomerase activity
TF3313_2285	COG0302	gtp cyclohydrolase
TF3313_2286	COG0009	L-threonylcarbamoyladenylate synthase
TF3313_2289	COG4690	dipeptidase activity
TF3313_2294	COG0545	Peptidyl-prolyl cis-trans isomerase
TF3313_2295	COG0545	Peptidyl-prolyl cis-trans isomerase
TF3313_2305	COG1629	transport
TF3313_2305	COG4206	TonB-dependent receptor
TF3313_2309	COG0823	Involved in the tonB-independent uptake of proteins
TF3313_2312	COG0463	Glycosyl transferase, family 2
TF3313_2313	COG1649	PFAM Uncharacterised BCR, COG1649
TF3313_2314	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TF3313_2319	COG0741	lytic transglycosylase activity
TF3313_2319	COG1388	LysM domain
TF3313_2320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TF3313_2322	COG1739	Uncharacterized protein family UPF0029
TF3313_2325	COG0006	proline dipeptidase activity
TF3313_2326	COG1785	Belongs to the alkaline phosphatase family
TF3313_2334	COG5549	protein import
TF3313_2334	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TF3313_2344	COG1649	PFAM Uncharacterised BCR, COG1649
TF3313_2346	COG0492	ferredoxin-NADP+ reductase activity
TF3313_2348	COG1674	ftsk spoiiie
TF3313_2349	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TF3313_2350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TF3313_2352	COG0037	tRNA processing
TF3313_2355	COG0450	alkyl hydroperoxide reductase
TF3313_2357	COG2197	response regulator
TF3313_2359	COG0569	domain protein
TF3313_2359	COG2985	domain, Protein
TF3313_2365	COG1620	l-lactate permease
TF3313_2366	COG1556	Lactate utilization protein
TF3313_2367	COG1139	Iron-sulfur cluster binding protein
TF3313_2376	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TF3313_2377	COG0321	lipoyl(octanoyl) transferase activity
TF3313_2379	COG1774	PSP1 C-terminal conserved region
TF3313_2380	COG0156	8-amino-7-oxononanoate synthase activity
TF3313_2381	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TF3313_2383	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TF3313_2384	COG0402	S-adenosylhomocysteine deaminase activity
TF3313_2395	COG1629	transport
TF3313_2395	COG4206	TonB-dependent receptor
TF3313_2396	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TF3313_2398	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TF3313_2399	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TF3313_2399	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TF3313_2401	COG0488	(ABC) transporter
TF3313_2403	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TF3313_2404	COG0706	membrane insertase activity
TF3313_2405	COG0504	CTP synthase activity
TF3313_2406	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TF3313_2410	COG1245	4Fe-4S binding domain
TF3313_2410	COG2878	Part of a membrane complex involved in electron transport
TF3313_2411	COG4656	Part of a membrane complex involved in electron transport
TF3313_2412	COG4658	electron transport chain
TF3313_2413	COG4659	FMN binding
TF3313_2414	COG4660	Part of a membrane complex involved in electron transport
TF3313_2415	COG4657	Part of a membrane complex involved in electron transport
TF3313_2423	COG2252	PERMEase
TF3313_2427	COG3119	arylsulfatase activity
TF3313_2429	COG2096	Adenosyltransferase
TF3313_2431	COG2242	protein methyltransferase activity
TF3313_2433	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TF3313_2439	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TF3313_2448	COG4206	TonB-dependent receptor
TF3313_2448	COG1629	transport
TF3313_2454	COG2115	Belongs to the xylose isomerase family
TF3313_2455	COG2814	Major facilitator Superfamily
TF3313_2455	COG0477	Major facilitator Superfamily
TF3313_2458	COG1629	transport
TF3313_2458	COG4206	TonB-dependent receptor
TF3313_2472	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TF3313_2473	COG1032	radical SAM domain protein
TF3313_2474	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TF3313_2475	COG0513	Belongs to the DEAD box helicase family
TF3313_2487	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TF3313_2489	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TF3313_2490	COG1663	tetraacyldisaccharide 4'-kinase activity
TF3313_2491	COG0616	signal peptide processing
TF3313_2494	COG0534	Mate efflux family protein
TF3313_2500	COG5002	protein histidine kinase activity
TF3313_2512	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TF3313_2512	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TF3313_2513	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TF3313_2514	COG0357	Ribosomal RNA small subunit methyltransferase G
TF3313_2517	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TF3313_2521	COG0671	phosphoesterase, PA-phosphatase related
TF3313_2525	COG2304	oxidoreductase activity
TF3313_2526	COG2304	oxidoreductase activity
TF3313_2529	COG0714	Associated with various cellular activities
TF3313_2531	COG0776	regulation of translation
TF3313_2532	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TF3313_2533	COG0552	protein localization to endoplasmic reticulum
TF3313_2544	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TF3313_2548	COG1530	ribonuclease E activity
TF3313_2549	COG0776	regulation of translation
TF3313_2552	COG0629	single-stranded DNA binding
TF3313_2553	COG4535	Mg2 and Co2 transporter CorC
TF3313_2560	COG4206	TonB-dependent receptor
TF3313_2560	COG1629	transport
TF3313_2564	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TF3313_2565	COG0671	phosphoesterase, PA-phosphatase related
TF3313_2572	COG0673	inositol 2-dehydrogenase activity
TF3313_2573	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TF3313_2574	COG2195	Cleaves the N-terminal amino acid of tripeptides
TF3313_2576	COG0463	Glycosyl transferase, family 2
TF3313_2578	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TF3313_2580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TF3313_2582	COG1611	Belongs to the LOG family
TF3313_2583	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TF3313_2587	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TF3313_2590	COG3537	Alpha-1,2-mannosidase
TF3313_2591	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TF3313_2592	COG2226	methyltransferase
TF3313_2593	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TF3313_2597	COG0006	proline dipeptidase activity
TF3313_2608	COG3250	beta-galactosidase activity
TF3313_2609	COG0481	GTPase activity
TF3313_2610	COG4206	TonB-dependent receptor
TF3313_2610	COG1629	transport
TF3313_2613	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TF3313_2614	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TF3313_2615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TF3313_2615	COG0574	Belongs to the PEP-utilizing enzyme family
TF3313_2620	COG0631	protein serine/threonine phosphatase activity
TF3313_2625	COG4206	TonB-dependent receptor
TF3313_2625	COG1629	transport
TF3313_2629	COG0156	8-amino-7-oxononanoate synthase activity
TF3313_2635	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TF3313_2639	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TF3313_2645	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TF3313_2646	COG0489	protein tyrosine kinase activity
TF3313_2648	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TF3313_2655	COG2194	sulfuric ester hydrolase activity
TF3313_2664	COG0300	oxidoreductase activity
TF3313_2667	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TF3313_2669	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TF3313_2670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TF3313_2675	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
TF3313_2676	COG0653	protein targeting
TF3313_2679	COG0242	peptide deformylase activity
TF3313_2680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TF3313_2681	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TF3313_2684	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TF3313_2685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TF3313_2686	COG4591	ABC-type transport system involved in lipoprotein release permease component
TF3313_2687	COG0436	Aminotransferase
TF3313_2689	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TF3313_2692	COG2873	o-acetylhomoserine
TF3313_2693	COG1668	transmembrane transport
TF3313_2694	COG4152	abc transporter atp-binding protein
TF3313_2704	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TF3313_2707	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TF3313_2710	COG1506	peptidase
TF3313_2710	COG0823	Involved in the tonB-independent uptake of proteins
TF3313_2711	COG0424	maF-like protein
TF3313_2712	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TF3313_2717	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TF3313_2718	COG0193	aminoacyl-tRNA hydrolase activity
TF3313_2719	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TF3313_2729	COG0681	Belongs to the peptidase S26 family
TF3313_2730	COG1132	(ABC) transporter
TF3313_2738	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TF3313_2743	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TF3313_2744	COG2268	Band 7 protein
TF3313_2749	COG0490	domain, Protein
TF3313_2749	COG2985	domain, Protein
TF3313_2765	COG1295	ribonuclease BN
TF3313_2767	COG0460	homoserine dehydrogenase
TF3313_2767	COG0527	aspartate kinase activity
TF3313_2768	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TF3313_2770	COG1242	4 iron, 4 sulfur cluster binding
TF3313_2772	COG0363	glucosamine-6-phosphate deaminase activity
TF3313_2773	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TF3313_2782	COG2832	Protein of unknown function (DUF454)
TF3313_2785	COG0778	Nitroreductase
TF3313_2786	COG0318	PFAM AMP-dependent synthetase and ligase
TF3313_2789	COG2801	Transposase and inactivated derivatives
TF3313_2794	COG1309	transcriptional regulator
TF3313_2805	COG1373	ATPase (AAA superfamily
TF3313_2830	COG4383	Mu-like prophage protein gp29
TF3313_2860	COG1192	Involved in chromosome partitioning
TF3313_2867	COG0739	heme binding
TF3313_2873	COG1373	ATPase (AAA superfamily
TF3313_2887	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TF3313_2889	COG0564	pseudouridine synthase activity
TF3313_2890	COG1181	Belongs to the D-alanine--D-alanine ligase family
TF3313_2892	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TF3313_2893	COG0179	Fumarylacetoacetate (FAA) hydrolase
TF3313_2897	COG0793	Belongs to the peptidase S41A family
TF3313_2897	COG4946	Tricorn protease homolog
TF3313_2898	COG3250	beta-galactosidase activity
TF3313_2900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TF3313_2907	COG1028	Short-chain dehydrogenase reductase Sdr
TF3313_2911	COG3022	response to hydroperoxide
TF3313_2922	COG0254	rRNA binding
TF3313_2923	COG0191	fructose-bisphosphate aldolase activity
TF3313_2924	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TF3313_2929	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TF3313_2933	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TF3313_2936	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TF3313_2937	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TF3313_2938	COG0805	protein transport
TF3313_2939	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TF3313_2940	COG0305	Participates in initiation and elongation during chromosome replication
TF3313_2942	COG0488	(ABC) transporter
TF3313_2944	COG0138	bifunctional purine biosynthesis protein purh
TF3313_2949	COG0772	Belongs to the SEDS family
TF3313_2950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TF3313_2951	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TF3313_2952	COG0166	Belongs to the GPI family
TF3313_2954	COG0360	Binds together with S18 to 16S ribosomal RNA
TF3313_2955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TF3313_2956	COG0359	binds to the 23S rRNA
TF3313_2957	COG0860	N-Acetylmuramoyl-L-alanine amidase