locus-tag	class	description
BFO_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BFO_0003	COG0335	large ribosomal subunit rRNA binding
BFO_0008	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFO_0011	COG3590	peptidase
BFO_0015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BFO_0016	COG1120	ATPase activity
BFO_0019	COG0543	2 iron, 2 sulfur cluster binding
BFO_0020	COG0167	dihydroorotate dehydrogenase activity
BFO_0023	COG1285	pathogenesis
BFO_0025	COG0101	tRNA pseudouridine synthase activity
BFO_0026	COG1797	cobyrinic acid a,c-diamide synthase activity
BFO_0028	COG5297	Belongs to the glycosyl hydrolase family 6
BFO_0028	COG3250	beta-galactosidase activity
BFO_0030	COG4206	TonB-dependent receptor
BFO_0030	COG1629	transport
BFO_0033	COG4206	TonB-dependent receptor
BFO_0033	COG1629	transport
BFO_0036	COG1215	transferase activity, transferring glycosyl groups
BFO_0038	COG2247	cell wall binding repeat
BFO_0038	COG2385	sporulation resulting in formation of a cellular spore
BFO_0039	COG2211	Major facilitator Superfamily
BFO_0040	COG3876	Protein conserved in bacteria
BFO_0043	COG0561	phosphatase activity
BFO_0044	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BFO_0060	COG0641	radical SAM
BFO_0079	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BFO_0088	COG2274	protein secretion by the type I secretion system
BFO_0092	COG0438	transferase activity, transferring glycosyl groups
BFO_0119	COG1187	pseudouridine synthase activity
BFO_0124	COG1132	(ABC) transporter
BFO_0125	COG1132	(ABC) transporter
BFO_0127	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BFO_0130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BFO_0141	COG3015	lipoprotein NlpE involved in copper resistance
BFO_0143	COG1970	mechanosensitive ion channel activity
BFO_0144	COG1051	belongs to the nudix hydrolase family
BFO_0145	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BFO_0147	COG0745	RESPONSE REGULATOR receiver
BFO_0147	COG2972	Histidine kinase
BFO_0152	COG4591	ABC-type transport system involved in lipoprotein release permease component
BFO_0152	COG1136	(ABC) transporter
BFO_0161	COG4191	Histidine kinase
BFO_0170	COG0438	transferase activity, transferring glycosyl groups
BFO_0175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BFO_0179	COG0237	dephospho-CoA kinase activity
BFO_0181	COG1862	Preprotein translocase
BFO_0182	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BFO_0184	COG0252	asparaginase activity
BFO_0188	COG4206	TonB-dependent receptor
BFO_0188	COG1629	transport
BFO_0193	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BFO_0197	COG1011	Hydrolase
BFO_0199	COG1595	DNA-templated transcription, initiation
BFO_0211	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BFO_0213	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BFO_0214	COG0235	Class ii aldolase
BFO_0216	COG4806	L-rhamnose isomerase
BFO_0217	COG1070	Carbohydrate kinase
BFO_0220	COG0442	prolyl-tRNA aminoacylation
BFO_0221	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BFO_0224	COG1704	LemA family
BFO_0225	COG0501	Belongs to the peptidase M48B family
BFO_0226	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BFO_0227	COG0126	phosphoglycerate kinase activity
BFO_0228	COG0534	Mate efflux family protein
BFO_0237	COG0484	heat shock protein binding
BFO_0238	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BFO_0239	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_0240	COG1193	negative regulation of DNA recombination
BFO_0243	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BFO_0245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BFO_0251	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BFO_0253	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BFO_0256	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BFO_0257	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BFO_0261	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BFO_0266	COG2264	protein methyltransferase activity
BFO_0271	COG1373	ATPase (AAA superfamily
BFO_0272	COG4804	nuclease activity
BFO_0277	COG3152	Membrane
BFO_0284	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BFO_0286	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BFO_0287	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BFO_0293	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
BFO_0294	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BFO_0298	COG4206	TonB-dependent receptor
BFO_0298	COG1629	transport
BFO_0300	COG3250	beta-galactosidase activity
BFO_0302	COG2431	L-lysine efflux transmembrane transporter activity
BFO_0303	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BFO_0304	COG3339	Conserved Protein
BFO_0307	COG0738	Major facilitator superfamily
BFO_0308	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BFO_0308	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BFO_0309	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BFO_0311	COG2885	chlorophyll binding
BFO_0312	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BFO_0312	COG1333	cytochrome c biogenesis protein
BFO_0313	COG0823	Involved in the tonB-independent uptake of proteins
BFO_0313	COG1506	peptidase
BFO_0315	COG3537	Alpha-1,2-mannosidase
BFO_0317	COG0534	Mate efflux family protein
BFO_0318	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BFO_0319	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BFO_0320	COG0297	glycogen (starch) synthase activity
BFO_0336	COG1045	serine acetyltransferase
BFO_0347	COG0681	Belongs to the peptidase S26 family
BFO_0374	COG0681	Belongs to the peptidase S26 family
BFO_0376	COG0463	Glycosyl transferase, family 2
BFO_0376	COG1216	Glycosyl transferase, family 2
BFO_0377	COG3591	Belongs to the peptidase S1B family
BFO_0380	COG2255	four-way junction helicase activity
BFO_0392	COG2860	membrane
BFO_0394	COG1629	transport
BFO_0394	COG4206	TonB-dependent receptor
BFO_0396	COG1610	YqeY-like protein
BFO_0397	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BFO_0400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BFO_0402	COG0772	Belongs to the SEDS family
BFO_0403	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BFO_0404	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BFO_0405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BFO_0406	COG0768	penicillin binding
BFO_0408	COG0275	rRNA processing
BFO_0411	COG0698	ribose 5-phosphate isomerase
BFO_0412	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BFO_0413	COG0427	acetyl-CoA hydrolase
BFO_0414	COG0546	phosphoglycolate phosphatase activity
BFO_0424	COG1595	DNA-templated transcription, initiation
BFO_0426	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BFO_0427	COG0658	competence protein
BFO_0427	COG2333	competence protein COMEC
BFO_0428	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BFO_0430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_0437	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BFO_0437	COG0519	Catalyzes the synthesis of GMP from XMP
BFO_0440	COG4886	Leucine-rich repeat (LRR) protein
BFO_0441	COG0501	Belongs to the peptidase M48B family
BFO_0442	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BFO_0443	COG0534	Mate efflux family protein
BFO_0444	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BFO_0448	COG0312	modulator of DNA gyrase
BFO_0450	COG3250	beta-galactosidase activity
BFO_0451	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BFO_0457	COG0363	glucosamine-6-phosphate deaminase activity
BFO_0458	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BFO_0462	COG1136	(ABC) transporter
BFO_0462	COG0577	efflux transmembrane transporter activity
BFO_0463	COG1136	(ABC) transporter
BFO_0463	COG0577	efflux transmembrane transporter activity
BFO_0464	COG1136	(ABC) transporter
BFO_0466	COG0366	Alpha amylase catalytic
BFO_0468	COG4953	penicillin-binding protein 1C
BFO_0469	COG2373	Large extracellular alpha-helical protein
BFO_0471	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BFO_0473	COG0165	Argininosuccinate lyase
BFO_0476	COG3341	Caulimovirus viroplasmin
BFO_0476	COG0328	RNA-DNA hybrid ribonuclease activity
BFO_0479	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
BFO_0481	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BFO_0482	COG1160	GTP binding
BFO_0484	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BFO_0485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BFO_0489	COG3537	Alpha-1,2-mannosidase
BFO_0495	COG1629	transport
BFO_0495	COG4206	TonB-dependent receptor
BFO_0497	COG4946	Tricorn protease homolog
BFO_0497	COG1506	peptidase
BFO_0497	COG0823	Involved in the tonB-independent uptake of proteins
BFO_0499	COG1629	transport
BFO_0499	COG4206	TonB-dependent receptor
BFO_0507	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BFO_0508	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BFO_0512	COG0180	Tryptophanyl-tRNA synthetase
BFO_0515	COG0039	L-malate dehydrogenase activity
BFO_0517	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BFO_0518	COG0569	domain protein
BFO_0519	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BFO_0521	COG4206	TonB-dependent receptor
BFO_0531	COG1396	sequence-specific DNA binding
BFO_0532	COG3550	peptidyl-serine autophosphorylation
BFO_0533	COG3550	peptidyl-serine autophosphorylation
BFO_0534	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BFO_0536	COG0556	nucleotide-excision repair
BFO_0539	COG3142	Participates in the control of copper homeostasis
BFO_0544	COG0438	transferase activity, transferring glycosyl groups
BFO_0545	COG0535	radical SAM domain protein
BFO_0548	COG3475	LICD family
BFO_0550	COG0584	glycerophosphoryl diester phosphodiesterase
BFO_0553	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BFO_0557	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
BFO_0561	COG4585	Histidine kinase
BFO_0562	COG2197	response regulator
BFO_0580	COG0084	hydrolase, TatD family'
BFO_0581	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BFO_0582	COG0594	ribonuclease P activity
BFO_0585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BFO_0588	COG1629	transport
BFO_0588	COG4206	TonB-dependent receptor
BFO_0593	COG0659	secondary active sulfate transmembrane transporter activity
BFO_0602	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BFO_0604	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BFO_0607	COG0793	Belongs to the peptidase S41A family
BFO_0609	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BFO_0610	COG0194	GDP metabolic process
BFO_0611	COG1561	YicC-like family, N-terminal region
BFO_0628	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BFO_0634	COG4974	Belongs to the 'phage' integrase family
BFO_0635	COG0582	viral genome integration into host DNA
BFO_0642	COG1022	Amp-dependent synthetase and ligase
BFO_0643	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BFO_0645	COG1215	transferase activity, transferring glycosyl groups
BFO_0651	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BFO_0652	COG0792	nuclease activity
BFO_0656	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BFO_0657	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BFO_0658	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BFO_0659	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BFO_0660	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BFO_0661	COG0356	it plays a direct role in the translocation of protons across the membrane
BFO_0663	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BFO_0664	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BFO_0667	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BFO_0668	COG1091	dTDP-4-dehydrorhamnose reductase activity
BFO_0671	COG0612	Peptidase, M16
BFO_0673	COG1696	Membrane protein involved in D-alanine export
BFO_0677	COG0443	Heat shock 70 kDa protein
BFO_0679	COG4974	Belongs to the 'phage' integrase family
BFO_0703	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_0703	COG5549	protein import
BFO_0705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BFO_0706	COG3386	PFAM SMP-30 Gluconolaconase
BFO_0707	COG0557	exoribonuclease II activity
BFO_0712	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
BFO_0712	COG0778	Nitroreductase
BFO_0716	COG2884	Cell division ATP-binding protein ftsE
BFO_0717	COG0527	aspartate kinase activity
BFO_0718	COG0019	diaminopimelate decarboxylase activity
BFO_0722	COG0673	inositol 2-dehydrogenase activity
BFO_0723	COG4206	TonB-dependent receptor
BFO_0723	COG1629	transport
BFO_0725	COG3119	arylsulfatase activity
BFO_0731	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BFO_0733	COG2986	histidine ammonia-lyase
BFO_0736	COG4206	TonB-dependent receptor
BFO_0742	COG0793	Belongs to the peptidase S41A family
BFO_0744	COG1192	Involved in chromosome partitioning
BFO_0745	COG1475	DNA binding
BFO_0747	COG3942	CHAP domain
BFO_0747	COG1388	LysM domain
BFO_0748	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BFO_0754	COG0739	heme binding
BFO_0755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BFO_0757	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BFO_0760	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BFO_0762	COG3119	arylsulfatase activity
BFO_0766	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BFO_0769	COG4676	Protein conserved in bacteria
BFO_0771	COG1228	amidohydrolase
BFO_0773	COG3404	Formiminotransferase-cyclodeaminase
BFO_0774	COG2986	histidine ammonia-lyase
BFO_0778	COG2996	Protein conserved in bacteria
BFO_0786	COG1136	(ABC) transporter
BFO_0787	COG0733	neurotransmitter:sodium symporter activity
BFO_0790	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BFO_0799	COG0758	DNA mediated transformation
BFO_0800	COG2194	sulfuric ester hydrolase activity
BFO_0802	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
BFO_0815	COG1482	cell wall glycoprotein biosynthetic process
BFO_0816	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BFO_0819	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BFO_0820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BFO_0822	COG0066	3-isopropylmalate dehydratase activity
BFO_0823	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BFO_0824	COG0473	3-isopropylmalate dehydrogenase activity
BFO_0828	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BFO_0831	COG3385	transposase activity
BFO_0837	COG0475	glutathione-regulated potassium exporter activity
BFO_0839	COG0826	peptidase U32
BFO_0840	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BFO_0841	COG1546	Belongs to the CinA family
BFO_0841	COG1058	Belongs to the CinA family
BFO_0842	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BFO_0846	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BFO_0847	COG0540	Belongs to the ATCase OTCase family
BFO_0853	COG0641	radical SAM
BFO_0860	COG2274	protein secretion by the type I secretion system
BFO_0895	COG0745	RESPONSE REGULATOR receiver
BFO_0902	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BFO_0903	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BFO_0907	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BFO_0908	COG1373	ATPase (AAA superfamily
BFO_0913	COG0560	Phosphoserine phosphatase
BFO_0919	COG1595	DNA-templated transcription, initiation
BFO_0922	COG2204	response regulator
BFO_0924	COG0802	atpase or kinase
BFO_0925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFO_0925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFO_0936	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BFO_0938	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BFO_0939	COG2715	membrane protein required for spore maturation
BFO_0941	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BFO_0942	COG0495	leucyl-tRNA aminoacylation
BFO_0943	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BFO_0944	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BFO_0947	COG1022	Amp-dependent synthetase and ligase
BFO_0948	COG1280	lysine exporter protein (LysE YggA)
BFO_0949	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BFO_0951	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BFO_0955	COG0084	hydrolase, TatD family'
BFO_0957	COG0811	peptide transport
BFO_0961	COG1522	sequence-specific DNA binding
BFO_0962	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BFO_0963	COG0511	ligase activity, forming carbon-carbon bonds
BFO_0965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BFO_0966	COG0346	lactoylglutathione lyase activity
BFO_0967	COG0528	UMP kinase activity
BFO_0970	COG4206	TonB-dependent receptor
BFO_0970	COG1629	transport
BFO_0971	COG0561	phosphatase activity
BFO_0973	COG1482	cell wall glycoprotein biosynthetic process
BFO_0974	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BFO_0989	COG0420	3'-5' exonuclease activity
BFO_0991	COG1940	carbohydrate kinase activity
BFO_0992	COG1703	isobutyryl-CoA mutase activity
BFO_0996	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BFO_0997	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BFO_0999	COG2233	PERMEase
BFO_1000	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BFO_1001	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BFO_1001	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BFO_1002	COG0142	geranyltranstransferase activity
BFO_1006	COG0726	polysaccharide deacetylase
BFO_1007	COG0823	Involved in the tonB-independent uptake of proteins
BFO_1007	COG1506	peptidase
BFO_1008	COG0116	Belongs to the methyltransferase superfamily
BFO_1012	COG4948	Mandelate Racemase Muconate Lactonizing
BFO_1015	COG0731	radical SAM domain protein
BFO_1015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BFO_1024	COG4206	TonB-dependent receptor
BFO_1024	COG1629	transport
BFO_1033	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BFO_1035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BFO_1035	COG0517	IMP dehydrogenase activity
BFO_1036	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFO_1038	COG2195	Cleaves the N-terminal amino acid of tripeptides
BFO_1040	COG1185	polyribonucleotide nucleotidyltransferase activity
BFO_1043	COG0438	transferase activity, transferring glycosyl groups
BFO_1051	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BFO_1052	COG3177	Filamentation induced by cAMP protein fic
BFO_1056	COG0367	asparagine synthase
BFO_1061	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BFO_1063	COG1083	cytidylyl-transferase
BFO_1064	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BFO_1065	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BFO_1066	COG2089	acid synthase
BFO_1071	COG1028	Short-chain dehydrogenase reductase Sdr
BFO_1073	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BFO_1074	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFO_1075	COG2244	polysaccharide biosynthetic process
BFO_1077	COG0673	inositol 2-dehydrogenase activity
BFO_1080	COG3409	Peptidoglycan-binding domain 1 protein
BFO_1080	COG0793	Belongs to the peptidase S41A family
BFO_1081	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BFO_1089	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BFO_1090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BFO_1091	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFO_1092	COG0571	ribonuclease III activity
BFO_1095	COG0205	6-phosphofructokinase activity
BFO_1096	COG0737	Belongs to the 5'-nucleotidase family
BFO_1099	COG0445	tRNA wobble uridine modification
BFO_1100	COG0322	excinuclease ABC activity
BFO_1101	COG1490	D-aminoacyl-tRNA deacylase activity
BFO_1103	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_1103	COG5549	protein import
BFO_1109	COG1234	tRNA 3'-trailer cleavage
BFO_1113	COG0509	glycine decarboxylation via glycine cleavage system
BFO_1114	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BFO_1115	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BFO_1121	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BFO_1125	COG2204	response regulator
BFO_1130	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BFO_1132	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFO_1134	COG2076	Multidrug Resistance protein
BFO_1137	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BFO_1138	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BFO_1150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BFO_1151	COG3119	arylsulfatase activity
BFO_1154	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BFO_1156	COG1904	glucuronate isomerase
BFO_1157	COG0205	6-phosphofructokinase activity
BFO_1166	COG0714	Associated with various cellular activities
BFO_1168	COG5549	protein import
BFO_1168	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_1174	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_1174	COG5549	protein import
BFO_1179	COG5549	protein import
BFO_1179	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_1183	COG2095	MarC family integral membrane protein
BFO_1185	COG0151	Belongs to the GarS family
BFO_1191	COG4206	TonB-dependent receptor
BFO_1191	COG1629	transport
BFO_1192	COG0561	phosphatase activity
BFO_1198	COG4206	TonB-dependent receptor
BFO_1198	COG1629	transport
BFO_1208	COG2197	response regulator
BFO_1211	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BFO_1215	COG0423	glycine-tRNA ligase activity
BFO_1218	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BFO_1218	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BFO_1222	COG4974	Belongs to the 'phage' integrase family
BFO_1236	COG0784	Response regulator, receiver
BFO_1236	COG2198	Histidine kinase
BFO_1236	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFO_1236	COG2205	protein histidine kinase activity
BFO_1298	COG4206	TonB-dependent receptor
BFO_1298	COG1629	transport
BFO_1302	COG2885	chlorophyll binding
BFO_1302	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BFO_1303	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BFO_1306	COG5434	Belongs to the glycosyl hydrolase 28 family
BFO_1308	COG1028	Short-chain dehydrogenase reductase Sdr
BFO_1309	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BFO_1316	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BFO_1320	COG2096	Adenosyltransferase
BFO_1323	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BFO_1329	COG0681	Belongs to the peptidase S26 family
BFO_1330	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BFO_1339	COG0233	cytoplasmic translational termination
BFO_1340	COG1162	GTPase activity
BFO_1341	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BFO_1345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BFO_1346	COG0280	phosphate acetyltransferase
BFO_1347	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BFO_1348	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BFO_1349	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BFO_1352	COG0826	peptidase U32
BFO_1363	COG1012	belongs to the aldehyde dehydrogenase family
BFO_1364	COG0813	purine-nucleoside phosphorylase activity
BFO_1366	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BFO_1368	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BFO_1369	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BFO_1369	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BFO_1370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BFO_1372	COG0284	orotidine-5'-phosphate decarboxylase activity
BFO_1373	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BFO_1374	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BFO_1380	COG3956	TIGRFAM MazG family protein
BFO_1381	COG3250	beta-galactosidase activity
BFO_1389	COG4974	Belongs to the 'phage' integrase family
BFO_1391	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BFO_1392	COG0598	Magnesium transport protein CorA
BFO_1393	COG0606	chelatase, subunit chli
BFO_1399	COG4206	TonB-dependent receptor
BFO_1399	COG1629	transport
BFO_1401	COG0463	Glycosyl transferase, family 2
BFO_1407	COG1629	transport
BFO_1407	COG4206	TonB-dependent receptor
BFO_1412	COG1629	transport
BFO_1412	COG4206	TonB-dependent receptor
BFO_1414	COG0012	GTP binding
BFO_1428	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BFO_1430	COG2003	Belongs to the UPF0758 family
BFO_1431	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BFO_1436	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BFO_1440	COG2890	protein-(glutamine-N5) methyltransferase activity
BFO_1441	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BFO_1441	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BFO_1444	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BFO_1448	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BFO_1451	COG1121	(ABC) transporter
BFO_1452	COG4591	ABC-type transport system involved in lipoprotein release permease component
BFO_1453	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BFO_1456	COG4206	TonB-dependent receptor
BFO_1456	COG1629	transport
BFO_1461	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BFO_1467	COG1956	GAF domain-containing protein
BFO_1469	COG0617	tRNA 3'-terminal CCA addition
BFO_1470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFO_1486	COG0427	acetyl-CoA hydrolase
BFO_1487	COG1454	alcohol dehydrogenase
BFO_1488	COG1012	belongs to the aldehyde dehydrogenase family
BFO_1489	COG1960	acyl-CoA dehydrogenase activity
BFO_1490	COG2086	electron transfer activity
BFO_1491	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BFO_1493	COG1137	ATPase activity
BFO_1494	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BFO_1497	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BFO_1499	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BFO_1500	COG0514	ATP-dependent DNA helicase (RecQ)
BFO_1501	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BFO_1502	COG0740	serine-type endopeptidase activity
BFO_1503	COG0544	peptidyl-prolyl cis-trans isomerase activity
BFO_1510	COG4206	TonB-dependent receptor
BFO_1511	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BFO_1515	COG0756	dUTP diphosphatase activity
BFO_1519	COG4206	TonB-dependent receptor
BFO_1519	COG1629	transport
BFO_1521	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BFO_1526	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BFO_1528	COG0124	histidyl-tRNA synthetase
BFO_1529	COG1404	Belongs to the peptidase S8 family
BFO_1535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BFO_1535	COG0551	DNA topoisomerase type I activity
BFO_1536	COG1595	DNA-templated transcription, initiation
BFO_1539	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BFO_1541	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BFO_1542	COG0049	tRNA binding
BFO_1543	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BFO_1544	COG0051	transcription antitermination factor activity, RNA binding
BFO_1545	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BFO_1546	COG0088	Forms part of the polypeptide exit tunnel
BFO_1547	COG0089	rRNA binding
BFO_1548	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BFO_1550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BFO_1552	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BFO_1553	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BFO_1554	COG0255	Belongs to the universal ribosomal protein uL29 family
BFO_1555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BFO_1556	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BFO_1557	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BFO_1558	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BFO_1559	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BFO_1560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BFO_1561	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BFO_1562	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BFO_1563	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BFO_1564	COG1841	ribosomal large subunit assembly
BFO_1565	COG0200	Binds to the 23S rRNA
BFO_1566	COG0201	protein transport
BFO_1568	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BFO_1569	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BFO_1570	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BFO_1571	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BFO_1572	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BFO_1573	COG0202	RNA polymerase activity
BFO_1574	COG0203	ribosomal protein L17
BFO_1575	COG1127	ABC transporter
BFO_1576	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BFO_1580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BFO_1581	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BFO_1592	COG0366	Alpha amylase catalytic
BFO_1593	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BFO_1595	COG0482	sulfurtransferase activity
BFO_1598	COG4771	TonB-dependent receptor
BFO_1612	COG0428	transporter
BFO_1614	COG2226	methyltransferase
BFO_1615	COG2226	methyltransferase
BFO_1618	COG2226	methyltransferase
BFO_1622	COG1132	(ABC) transporter
BFO_1624	COG1132	(ABC) transporter
BFO_1625	COG2066	Belongs to the glutaminase family
BFO_1629	COG0196	riboflavin kinase activity
BFO_1634	COG5492	domain, Protein
BFO_1635	COG0641	radical SAM
BFO_1637	COG1053	succinate dehydrogenase
BFO_1640	COG0018	arginyl-trna synthetase
BFO_1643	COG0525	valine-tRNA ligase activity
BFO_1658	COG1242	4 iron, 4 sulfur cluster binding
BFO_1660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BFO_1666	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BFO_1666	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BFO_1670	COG0779	Required for maturation of 30S ribosomal subunits
BFO_1671	COG0195	Participates in both transcription termination and antitermination
BFO_1671	COG2251	uridine kinase activity
BFO_1672	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BFO_1674	COG0719	Fe-S assembly protein
BFO_1675	COG0396	ATPase activity
BFO_1676	COG0719	Fe-S assembly protein
BFO_1680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BFO_1681	COG0436	Aminotransferase
BFO_1687	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BFO_1690	COG0393	Putative heavy-metal-binding
BFO_1691	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BFO_1692	COG2166	iron-sulfur cluster assembly
BFO_1694	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BFO_1695	COG0187	DNA topoisomerase II activity
BFO_1712	COG0268	Binds directly to 16S ribosomal RNA
BFO_1715	COG4206	TonB-dependent receptor
BFO_1715	COG1629	transport
BFO_1718	COG1629	transport
BFO_1718	COG4206	TonB-dependent receptor
BFO_1720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BFO_1722	COG3118	belongs to the thioredoxin family
BFO_1728	COG0228	four-way junction DNA binding
BFO_1731	COG0514	ATP-dependent DNA helicase (RecQ)
BFO_1733	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BFO_1733	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BFO_1736	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BFO_1740	COG0542	response to heat
BFO_1741	COG1253	flavin adenine dinucleotide binding
BFO_1742	COG1760	l-serine dehydratase
BFO_1743	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BFO_1744	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BFO_1745	COG0612	Peptidase, M16
BFO_1750	COG1940	carbohydrate kinase activity
BFO_1759	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BFO_1760	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BFO_1760	COG0674	pyruvate-flavodoxin oxidoreductase activity
BFO_1761	COG1013	pyruvate-flavodoxin oxidoreductase activity
BFO_1762	COG2177	Part of the ABC transporter FtsEX involved in
BFO_1764	COG1968	undecaprenyl-diphosphatase activity
BFO_1765	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BFO_1766	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BFO_1767	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BFO_1778	COG1595	DNA-templated transcription, initiation
BFO_1780	COG0539	negative regulation of cytoplasmic translation
BFO_1782	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BFO_1783	COG1151	hydroxylamine reductase activity
BFO_1786	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BFO_1792	COG1271	oxidase subunit
BFO_1794	COG1595	DNA-templated transcription, initiation
BFO_1796	COG1629	transport
BFO_1796	COG4206	TonB-dependent receptor
BFO_1798	COG0673	inositol 2-dehydrogenase activity
BFO_1801	COG0612	Peptidase, M16
BFO_1802	COG0038	chloride channel
BFO_1803	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BFO_1807	COG0363	glucosamine-6-phosphate deaminase activity
BFO_1809	COG0426	domain, Protein
BFO_1810	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BFO_1811	COG0673	inositol 2-dehydrogenase activity
BFO_1812	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BFO_1813	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BFO_1814	COG0137	argininosuccinate synthase activity
BFO_1816	COG1438	arginine binding
BFO_1819	COG2211	Major facilitator Superfamily
BFO_1823	COG1032	radical SAM domain protein
BFO_1826	COG1131	(ABC) transporter
BFO_1829	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BFO_1830	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BFO_1831	COG0742	ribosomal rna small subunit methyltransferase
BFO_1832	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BFO_1838	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BFO_1840	COG1011	Hydrolase
BFO_1843	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BFO_1844	COG1492	cobalamin metabolic process
BFO_1845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BFO_1846	COG0251	oxidation-reduction process
BFO_1848	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BFO_1849	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BFO_1853	COG3209	COG3209 Rhs family protein
BFO_1856	COG3209	COG3209 Rhs family protein
BFO_1858	COG3209	COG3209 Rhs family protein
BFO_1860	COG3209	COG3209 Rhs family protein
BFO_1862	COG3209	COG3209 Rhs family protein
BFO_1874	COG0336	Belongs to the RNA methyltransferase TrmD family
BFO_1876	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFO_1876	COG0072	phenylalanine-tRNA ligase activity
BFO_1877	COG0217	transcriptional regulatory protein
BFO_1880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BFO_1882	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BFO_1883	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BFO_1884	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BFO_1885	COG0791	NLP P60 protein
BFO_1886	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BFO_1887	COG1408	metallophosphoesterase
BFO_1892	COG4139	cobalamin transport
BFO_1897	COG0632	four-way junction helicase activity
BFO_1900	COG1074	ATP-dependent DNA helicase activity
BFO_1901	COG0688	phosphatidylethanolamine metabolic process
BFO_1902	COG1183	phosphatidylcholine synthase activity
BFO_1905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BFO_1914	COG0737	Belongs to the 5'-nucleotidase family
BFO_1923	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BFO_1924	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BFO_1927	COG1381	Involved in DNA repair and RecF pathway recombination
BFO_1930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BFO_1932	COG2843	Capsule synthesis protein
BFO_1933	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BFO_1934	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BFO_1935	COG4974	Belongs to the 'phage' integrase family
BFO_1939	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BFO_1942	COG0250	Participates in transcription elongation, termination and antitermination
BFO_1943	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BFO_1944	COG0081	regulation of translation
BFO_1945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BFO_1946	COG0222	ribosome binding
BFO_1947	COG0085	RNA polymerase activity
BFO_1948	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BFO_1949	COG0433	COG0433 Predicted ATPase
BFO_1952	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BFO_1953	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BFO_1954	COG4948	Mandelate Racemase Muconate Lactonizing
BFO_1962	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BFO_1963	COG4804	nuclease activity
BFO_1964	COG0732	type I restriction modification DNA specificity domain
BFO_1965	COG4974	Belongs to the 'phage' integrase family
BFO_1966	COG0732	type I restriction modification DNA specificity domain
BFO_1976	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BFO_1987	COG1216	Glycosyl transferase, family 2
BFO_1991	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BFO_2003	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BFO_2006	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BFO_2006	COG0047	phosphoribosylformylglycinamidine synthase activity
BFO_2013	COG1629	transport
BFO_2013	COG4206	TonB-dependent receptor
BFO_2016	COG4221	oxidoreductase activity
BFO_2020	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BFO_2021	COG1368	sulfuric ester hydrolase activity
BFO_2022	COG1047	Peptidyl-prolyl cis-trans
BFO_2023	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_2024	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BFO_2027	COG0750	zinc metalloprotease
BFO_2029	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BFO_2030	COG4942	peptidase
BFO_2031	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BFO_2035	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BFO_2036	COG2183	response to ionizing radiation
BFO_2041	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BFO_2043	COG0488	(ABC) transporter
BFO_2044	COG0516	GMP reductase activity
BFO_2045	COG1918	ferrous iron import across plasma membrane
BFO_2045	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BFO_2047	COG3275	phosphorelay sensor kinase activity
BFO_2048	COG3279	Response regulator of the LytR AlgR family
BFO_2068	COG0148	phosphopyruvate hydratase activity
BFO_2070	COG0716	FMN binding
BFO_2076	COG4771	TonB-dependent receptor
BFO_2077	COG4771	TonB-dependent receptor
BFO_2081	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BFO_2082	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BFO_2083	COG4886	Leucine-rich repeat (LRR) protein
BFO_2092	COG3876	Protein conserved in bacteria
BFO_2094	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BFO_2095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BFO_2096	COG0052	Belongs to the universal ribosomal protein uS2 family
BFO_2097	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BFO_2107	COG1629	transport
BFO_2107	COG4206	TonB-dependent receptor
BFO_2116	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BFO_2116	COG4651	solute:proton antiporter activity
BFO_2118	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BFO_2123	COG1418	mRNA catabolic process
BFO_2124	COG0488	(ABC) transporter
BFO_2125	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BFO_2129	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BFO_2136	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BFO_2140	COG3876	Protein conserved in bacteria
BFO_2141	COG2871	sodium ion transport
BFO_2142	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BFO_2143	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BFO_2145	COG1805	sodium ion transport
BFO_2146	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BFO_2148	COG0739	heme binding
BFO_2149	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BFO_2150	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BFO_2151	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BFO_2152	COG0563	adenylate kinase activity
BFO_2154	COG3845	ABC transporter
BFO_2156	COG0346	lactoylglutathione lyase activity
BFO_2159	COG0463	Glycosyl transferase, family 2
BFO_2161	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BFO_2162	COG4452	Inner membrane protein CreD
BFO_2174	COG1028	Short-chain dehydrogenase reductase Sdr
BFO_2175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BFO_2176	COG1309	transcriptional regulator
BFO_2182	COG1472	Belongs to the glycosyl hydrolase 3 family
BFO_2183	COG2885	chlorophyll binding
BFO_2189	COG0542	response to heat
BFO_2202	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BFO_2204	COG2271	Major facilitator Superfamily
BFO_2205	COG4206	TonB-dependent receptor
BFO_2205	COG1629	transport
BFO_2208	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BFO_2214	COG4822	anaerobic cobalamin biosynthetic process
BFO_2217	COG4771	TonB-dependent receptor
BFO_2219	COG1477	protein flavinylation
BFO_2224	COG1480	7TM receptor with intracellular HD hydrolase
BFO_2259	COG1072	(Pantothenic acid kinase))
BFO_2263	COG1131	(ABC) transporter
BFO_2264	COG1131	(ABC) transporter
BFO_2265	COG0842	Transport permease protein
BFO_2270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BFO_2271	COG4206	TonB-dependent receptor
BFO_2271	COG1629	transport
BFO_2272	COG1082	Xylose isomerase domain protein TIM barrel
BFO_2274	COG0343	queuine tRNA-ribosyltransferase activity
BFO_2277	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BFO_2279	COG1773	rubredoxin
BFO_2280	COG0583	DNA-binding transcription factor activity
BFO_2282	COG0668	transmembrane transport
BFO_2283	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BFO_2285	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BFO_2286	COG1629	transport
BFO_2286	COG4206	TonB-dependent receptor
BFO_2288	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BFO_2290	COG3119	arylsulfatase activity
BFO_2293	COG1028	Short-chain dehydrogenase reductase Sdr
BFO_2295	COG2271	Major facilitator Superfamily
BFO_2299	COG0577	efflux transmembrane transporter activity
BFO_2315	COG1570	exodeoxyribonuclease VII activity
BFO_2318	COG2502	aspartate--ammonia ligase
BFO_2320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BFO_2320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BFO_2321	COG1752	Esterase of the alpha-beta hydrolase superfamily
BFO_2323	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BFO_2335	COG3177	Filamentation induced by cAMP protein fic
BFO_2337	COG1353	crispr-associated protein
BFO_2339	COG1337	RAMP superfamily
BFO_2343	COG1518	maintenance of DNA repeat elements
BFO_2344	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BFO_2494	COG1528	Iron-storage protein
BFO_2495	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BFO_2499	COG0776	regulation of translation
BFO_2500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BFO_2501	COG1640	4-alpha-glucanotransferase
BFO_2505	COG4589	Belongs to the CDS family
BFO_2507	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BFO_2508	COG0799	negative regulation of ribosome biogenesis
BFO_2513	COG4206	TonB-dependent receptor
BFO_2513	COG1629	transport
BFO_2521	COG0285	dihydrofolate synthase activity
BFO_2522	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BFO_2523	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BFO_2536	COG0497	DNA recombination
BFO_2537	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BFO_2538	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BFO_2539	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BFO_2540	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BFO_2541	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BFO_2543	COG2195	Cleaves the N-terminal amino acid of tripeptides
BFO_2547	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BFO_2548	COG1979	alcohol dehydrogenase
BFO_2553	COG3250	beta-galactosidase activity
BFO_2554	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFO_2557	COG0470	DNA polymerase III
BFO_2558	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BFO_2560	COG0534	Mate efflux family protein
BFO_2562	COG1629	transport
BFO_2562	COG4206	TonB-dependent receptor
BFO_2569	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BFO_2570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BFO_2571	COG1748	Saccharopine dehydrogenase
BFO_2574	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BFO_2575	COG1215	transferase activity, transferring glycosyl groups
BFO_2589	COG3209	COG3209 Rhs family protein
BFO_2600	COG1629	transport
BFO_2600	COG4206	TonB-dependent receptor
BFO_2606	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BFO_2610	COG0739	heme binding
BFO_2613	COG0149	triose-phosphate isomerase activity
BFO_2615	COG0302	gtp cyclohydrolase
BFO_2616	COG0009	L-threonylcarbamoyladenylate synthase
BFO_2619	COG4690	dipeptidase activity
BFO_2625	COG0545	Peptidyl-prolyl cis-trans isomerase
BFO_2626	COG0545	Peptidyl-prolyl cis-trans isomerase
BFO_2635	COG1629	transport
BFO_2635	COG4206	TonB-dependent receptor
BFO_2640	COG0823	Involved in the tonB-independent uptake of proteins
BFO_2643	COG0463	Glycosyl transferase, family 2
BFO_2644	COG1649	PFAM Uncharacterised BCR, COG1649
BFO_2645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFO_2648	COG0860	N-Acetylmuramoyl-L-alanine amidase
BFO_2648	COG1388	LysM domain
BFO_2652	COG1388	LysM domain
BFO_2652	COG0741	lytic transglycosylase activity
BFO_2653	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BFO_2655	COG1739	Uncharacterized protein family UPF0029
BFO_2658	COG0006	proline dipeptidase activity
BFO_2659	COG1785	Belongs to the alkaline phosphatase family
BFO_2661	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_2661	COG5549	protein import
BFO_2665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_2665	COG5549	protein import
BFO_2669	COG5549	protein import
BFO_2669	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_2675	COG5549	protein import
BFO_2675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_2679	COG5549	protein import
BFO_2679	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFO_2689	COG1649	PFAM Uncharacterised BCR, COG1649
BFO_2691	COG0492	ferredoxin-NADP+ reductase activity
BFO_2693	COG1674	ftsk spoiiie
BFO_2694	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BFO_2695	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BFO_2697	COG0037	tRNA processing
BFO_2700	COG0450	alkyl hydroperoxide reductase
BFO_2702	COG2197	response regulator
BFO_2705	COG2966	Psort location CytoplasmicMembrane, score
BFO_2713	COG1620	l-lactate permease
BFO_2714	COG1556	Lactate utilization protein
BFO_2715	COG1139	Iron-sulfur cluster binding protein
BFO_2724	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BFO_2725	COG0321	lipoyl(octanoyl) transferase activity
BFO_2727	COG1774	PSP1 C-terminal conserved region
BFO_2728	COG0156	8-amino-7-oxononanoate synthase activity
BFO_2729	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BFO_2731	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BFO_2732	COG0402	S-adenosylhomocysteine deaminase activity
BFO_2743	COG4206	TonB-dependent receptor
BFO_2743	COG1629	transport
BFO_2744	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BFO_2746	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFO_2747	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFO_2747	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFO_2749	COG0488	(ABC) transporter
BFO_2751	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BFO_2752	COG0706	membrane insertase activity
BFO_2753	COG0504	CTP synthase activity
BFO_2754	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BFO_2758	COG1245	4Fe-4S binding domain
BFO_2758	COG2878	Part of a membrane complex involved in electron transport
BFO_2759	COG4656	Part of a membrane complex involved in electron transport
BFO_2760	COG4658	electron transport chain
BFO_2761	COG4659	FMN binding
BFO_2762	COG4660	Part of a membrane complex involved in electron transport
BFO_2763	COG4657	Part of a membrane complex involved in electron transport
BFO_2773	COG2252	PERMEase
BFO_2777	COG3119	arylsulfatase activity
BFO_2779	COG2096	Adenosyltransferase
BFO_2781	COG2242	protein methyltransferase activity
BFO_2783	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BFO_2791	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFO_2795	COG3104	oligopeptide transport
BFO_2801	COG4206	TonB-dependent receptor
BFO_2801	COG1629	transport
BFO_2807	COG2115	Belongs to the xylose isomerase family
BFO_2808	COG2814	Major facilitator Superfamily
BFO_2808	COG0477	Major facilitator Superfamily
BFO_2812	COG1629	transport
BFO_2812	COG4206	TonB-dependent receptor
BFO_2826	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BFO_2828	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BFO_2829	COG0513	Belongs to the DEAD box helicase family
BFO_2841	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BFO_2842	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BFO_2844	COG1663	tetraacyldisaccharide 4'-kinase activity
BFO_2845	COG0616	signal peptide processing
BFO_2848	COG0534	Mate efflux family protein
BFO_2851	COG1505	serine-type exopeptidase activity
BFO_2853	COG5002	protein histidine kinase activity
BFO_2867	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BFO_2867	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BFO_2868	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BFO_2869	COG0357	Ribosomal RNA small subunit methyltransferase G
BFO_2872	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BFO_2876	COG0671	phosphoesterase, PA-phosphatase related
BFO_2880	COG2304	oxidoreductase activity
BFO_2881	COG2304	oxidoreductase activity
BFO_2884	COG0714	Associated with various cellular activities
BFO_2886	COG0776	regulation of translation
BFO_2887	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BFO_2888	COG0552	protein localization to endoplasmic reticulum
BFO_2899	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BFO_2903	COG1530	ribonuclease E activity
BFO_2904	COG0776	regulation of translation
BFO_2907	COG0629	single-stranded DNA binding
BFO_2908	COG4535	Mg2 and Co2 transporter CorC
BFO_2915	COG4206	TonB-dependent receptor
BFO_2915	COG1629	transport
BFO_2919	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFO_2920	COG0671	phosphoesterase, PA-phosphatase related
BFO_2928	COG0673	inositol 2-dehydrogenase activity
BFO_2929	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BFO_2930	COG2195	Cleaves the N-terminal amino acid of tripeptides
BFO_2932	COG0463	Glycosyl transferase, family 2
BFO_2934	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BFO_2936	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BFO_2938	COG1611	Belongs to the LOG family
BFO_2939	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BFO_2943	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BFO_2947	COG3537	Alpha-1,2-mannosidase
BFO_2948	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BFO_2949	COG2226	methyltransferase
BFO_2950	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BFO_2955	COG0006	proline dipeptidase activity
BFO_2968	COG3250	beta-galactosidase activity
BFO_2969	COG0481	GTPase activity
BFO_2970	COG1629	transport
BFO_2970	COG4206	TonB-dependent receptor
BFO_2973	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BFO_2974	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BFO_2975	COG0574	Belongs to the PEP-utilizing enzyme family
BFO_2975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BFO_2985	COG1629	transport
BFO_2985	COG4206	TonB-dependent receptor
BFO_2989	COG0156	8-amino-7-oxononanoate synthase activity
BFO_2995	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BFO_2999	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BFO_3007	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BFO_3008	COG0489	protein tyrosine kinase activity
BFO_3010	COG0793	Belongs to the peptidase S41A family
BFO_3011	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFO_3021	COG2194	sulfuric ester hydrolase activity
BFO_3030	COG0300	oxidoreductase activity
BFO_3033	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BFO_3035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BFO_3036	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BFO_3041	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
BFO_3042	COG0653	protein targeting
BFO_3045	COG0242	peptide deformylase activity
BFO_3046	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BFO_3047	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BFO_3050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BFO_3051	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BFO_3052	COG4591	ABC-type transport system involved in lipoprotein release permease component
BFO_3053	COG0436	Aminotransferase
BFO_3055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BFO_3057	COG1678	Uncharacterized ACR, COG1678
BFO_3058	COG2873	o-acetylhomoserine
BFO_3059	COG1668	transmembrane transport
BFO_3060	COG4152	abc transporter atp-binding protein
BFO_3061	COG0358	DNA primase activity
BFO_3077	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BFO_3080	COG0823	Involved in the tonB-independent uptake of proteins
BFO_3080	COG1506	peptidase
BFO_3081	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFO_3082	COG0424	maF-like protein
BFO_3087	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BFO_3088	COG0193	aminoacyl-tRNA hydrolase activity
BFO_3089	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BFO_3099	COG0681	Belongs to the peptidase S26 family
BFO_3100	COG1132	(ABC) transporter
BFO_3103	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFO_3106	COG1575	Belongs to the MenA family. Type 1 subfamily
BFO_3110	COG1629	transport
BFO_3110	COG4206	TonB-dependent receptor
BFO_3117	COG0848	biopolymer transport protein
BFO_3118	COG0811	peptide transport
BFO_3119	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BFO_3120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BFO_3130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BFO_3131	COG2268	Band 7 protein
BFO_3136	COG0490	domain, Protein
BFO_3136	COG2985	domain, Protein
BFO_3151	COG1295	ribonuclease BN
BFO_3153	COG0527	aspartate kinase activity
BFO_3153	COG0460	homoserine dehydrogenase
BFO_3154	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
BFO_3156	COG0363	glucosamine-6-phosphate deaminase activity
BFO_3158	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BFO_3170	COG2832	Protein of unknown function (DUF454)
BFO_3175	COG0318	PFAM AMP-dependent synthetase and ligase
BFO_3176	COG2801	Transposase and inactivated derivatives
BFO_3185	COG1309	transcriptional regulator
BFO_3197	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BFO_3198	COG4948	Mandelate Racemase Muconate Lactonizing
BFO_3199	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BFO_3200	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BFO_3204	COG1373	ATPase (AAA superfamily
BFO_3209	COG0731	radical SAM domain protein
BFO_3209	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BFO_3243	COG4974	Belongs to the 'phage' integrase family
BFO_3245	COG4974	Belongs to the 'phage' integrase family
BFO_3252	COG3645	SOS response
BFO_3257	COG2207	Transcriptional regulator
BFO_3257	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BFO_3264	COG1373	ATPase (AAA superfamily
BFO_3270	COG1196	nuclear chromosome segregation
BFO_3273	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BFO_3287	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BFO_3289	COG0564	pseudouridine synthase activity
BFO_3290	COG1181	Belongs to the D-alanine--D-alanine ligase family
BFO_3292	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BFO_3293	COG0179	Fumarylacetoacetate (FAA) hydrolase
BFO_3297	COG0793	Belongs to the peptidase S41A family
BFO_3297	COG4946	Tricorn protease homolog
BFO_3298	COG3250	beta-galactosidase activity
BFO_3300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BFO_3307	COG1028	Short-chain dehydrogenase reductase Sdr
BFO_3311	COG3022	response to hydroperoxide
BFO_3314	COG1629	transport
BFO_3314	COG4206	TonB-dependent receptor
BFO_3328	COG0254	rRNA binding
BFO_3329	COG0191	fructose-bisphosphate aldolase activity
BFO_3330	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BFO_3336	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BFO_3342	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BFO_3343	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BFO_3344	COG0805	protein transport
BFO_3345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BFO_3346	COG0305	Participates in initiation and elongation during chromosome replication
BFO_3348	COG0488	(ABC) transporter
BFO_3350	COG0138	bifunctional purine biosynthesis protein purh
BFO_3355	COG0772	Belongs to the SEDS family
BFO_3356	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BFO_3357	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BFO_3358	COG0166	Belongs to the GPI family
BFO_3360	COG0360	Binds together with S18 to 16S ribosomal RNA
BFO_3361	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BFO_3362	COG0359	binds to the 23S rRNA
BFO_3363	COG0860	N-Acetylmuramoyl-L-alanine amidase