locus-tag	class	description
TFKS16_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
TFKS16_0003	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
TFKS16_0008	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
TFKS16_0011	ENOG4105C9K	Endothelin-converting enzyme 1
TFKS16_0014	ENOG4105EHG	Permease protein
TFKS16_0015	ENOG4105E0A	ABC, transporter
TFKS16_0018	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
TFKS16_0019	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
TFKS16_0022	ENOG4105KT7	mgtC SapB transporter
TFKS16_0024	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
TFKS16_0026	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
TFKS16_0027	ENOG4105E08	Glycoside hydrolase, family 9
TFKS16_0029	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0032	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0037	ENOG4105JFG	SpoIID LytB domain protein
TFKS16_0039	ENOG4105EHZ	conserved protein UCP016719
TFKS16_0042	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TFKS16_0043	ENOG410667J	hydrolase
TFKS16_0056	ENOG4105C4X	radical SAM domain protein
TFKS16_0067	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
TFKS16_0075	ENOG4105WXW	Antirepressor
TFKS16_0076	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
TFKS16_0099	ENOG4108JJA	ABC, transporter
TFKS16_0103	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
TFKS16_0109	ENOG4108JJA	ABC, transporter
TFKS16_0117	ENOG4105FE9	pseudouridine synthase
TFKS16_0118	ENOG4107QTF	adenylosuccinate lyase
TFKS16_0122	ENOG4105BZ1	(ABC) transporter
TFKS16_0123	ENOG4105BZ1	(ABC) transporter
TFKS16_0125	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
TFKS16_0134	ENOG4105F1A	Pyruvate formate-lyase
TFKS16_0136	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
TFKS16_0137	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
TFKS16_0138	ENOG4105BZ8	glutamate synthase
TFKS16_0139	ENOG4107EII	Lipoprotein involved with copper homeostasis and adhesion
TFKS16_0142	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
TFKS16_0143	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
TFKS16_0144	ENOG4108NEV	two component transcriptional regulator, LytTR family
TFKS16_0150	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
TFKS16_0159	ENOG4105BZU	Histidine kinase
TFKS16_0168	ENOG4105CPK	Glycosyl transferase (Group 1
TFKS16_0170	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TFKS16_0173	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
TFKS16_0175	ENOG4105VIE	preprotein translocase, subunit YajC
TFKS16_0176	ENOG4107R6T	Involved in the transcription termination process (By similarity)
TFKS16_0178	ENOG4105HDK	L-asparaginase
TFKS16_0182	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0188	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
TFKS16_0207	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
TFKS16_0209	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
TFKS16_0210	ENOG4105C9J	Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity)
TFKS16_0212	ENOG4105DKG	l-rhamnose isomerase
TFKS16_0213	ENOG4105DET	Rhamnulokinase
TFKS16_0216	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
TFKS16_0217	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
TFKS16_0220	ENOG4108V0P	LemA family
TFKS16_0221	ENOG4105D0M	Protease HtpX homolog
TFKS16_0222	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TFKS16_0223	ENOG4105BZA	Phosphoglycerate kinase
TFKS16_0224	ENOG4107QJQ	Mate efflux family protein
TFKS16_0226	ENOG4105CTQ	phosphohexokinase
TFKS16_0233	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
TFKS16_0234	ENOG4107XPB	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TFKS16_0235	ENOG4105C98	muts2 protein
TFKS16_0236	ENOG4105DFA	alanine racemase domain protein
TFKS16_0238	ENOG4108Z9I	-acetyltransferase
TFKS16_0244	ENOG4108JA2	transcriptioN-repair coupling factor
TFKS16_0246	ENOG4105C10	Electron transfer flavoprotein
TFKS16_0247	ENOG4105BZJ	Electron transfer flavoprotein
TFKS16_0249	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
TFKS16_0250	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
TFKS16_0253	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
TFKS16_0257	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
TFKS16_0259	ENOG4105WH1	Two component transcriptional regulator luxr family
TFKS16_0261	ENOG4105E4P	ATPase (AAA
TFKS16_0262	ENOG4105DFS	Conserved Protein
TFKS16_0267	ENOG4105KAF	membrAne
TFKS16_0274	ENOG4105CMR	udp-glucose 4-epimerase
TFKS16_0276	ENOG41083ND	50S ribosomal protein L33
TFKS16_0277	ENOG4105KDC	50s ribosomal protein l28
TFKS16_0283	ENOG4108ZQX	ybak prolyl-trna synthetase
TFKS16_0284	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
TFKS16_0288	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0290	ENOG4105CNT	hydrolase family 2
TFKS16_0292	ENOG4105DWU	Membrane
TFKS16_0293	ENOG4105Q2H	domain protein
TFKS16_0297	ENOG4105EDR	glucose galactose transporter
TFKS16_0298	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
TFKS16_0299	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
TFKS16_0301	ENOG4105RWF	major outer membrane protein OmpA
TFKS16_0302	ENOG4105CRE	cytochrome C
TFKS16_0303	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
TFKS16_0305	ENOG4105CWX	Alpha-1,2-mannosidase
TFKS16_0307	ENOG4107QI1	Mate efflux family protein
TFKS16_0308	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
TFKS16_0309	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
TFKS16_0310	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
TFKS16_0332	ENOG4105DSJ	YicC domain protein
TFKS16_0333	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
TFKS16_0334	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
TFKS16_0339	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
TFKS16_0341	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
TFKS16_0349	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
TFKS16_0350	ENOG4105CHH	sulfate transporter
TFKS16_0354	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0357	ENOG4108IYU	L-aspartate oxidase
TFKS16_0360	ENOG4105WG6	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
TFKS16_0361	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
TFKS16_0362	ENOG4105F8V	Hydrolase, tatD family
TFKS16_0379	ENOG4105WH1	Two component transcriptional regulator luxr family
TFKS16_0380	ENOG4105BZU	Histidine kinase
TFKS16_0384	ENOG4107RVI	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
TFKS16_0385	ENOG4107RQX	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TFKS16_0391	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
TFKS16_0393	ENOG4105KPE	licD family
TFKS16_0396	ENOG4107ZBH	radical SAM domain protein
TFKS16_0397	ENOG4107XU6	Glycosyl transferase (Group 1
TFKS16_0401	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
TFKS16_0402	ENOG4106N3A	copper homeostasis protein cutc
TFKS16_0405	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
TFKS16_0407	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
TFKS16_0408	ENOG4108KSB	HipA-like N-terminal domain
TFKS16_0409	ENOG4105MHH	HipA N-terminal domain protein
TFKS16_0421	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
TFKS16_0423	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
TFKS16_0424	ENOG4105C1A	potassium transporter peripheral membrane
TFKS16_0425	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
TFKS16_0427	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
TFKS16_0430	ENOG4105C31	Tryptophanyl-tRNA synthetase
TFKS16_0434	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
TFKS16_0435	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
TFKS16_0441	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0443	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
TFKS16_0445	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0450	ENOG4105CWX	Alpha-1,2-mannosidase
TFKS16_0454	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
TFKS16_0455	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
TFKS16_0457	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
TFKS16_0458	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
TFKS16_0460	ENOG4108YZT	Adenosylcobinamide kinase
TFKS16_0463	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
TFKS16_0465	ENOG4105CH7	arginosuccinase
TFKS16_0467	ENOG4107RIV	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
TFKS16_0469	ENOG4105DN3	alpha-2-macroglobulin domain protein
TFKS16_0470	ENOG4108JQB	penicillin-binding protein 1C
TFKS16_0472	ENOG4108IUK	alpha amylase, catalytic
TFKS16_0474	ENOG4105C19	ABC transporter
TFKS16_0475	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TFKS16_0481	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
TFKS16_0482	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
TFKS16_0487	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TFKS16_0488	ENOG4105CNT	hydrolase family 2
TFKS16_0490	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
TFKS16_0494	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
TFKS16_0495	ENOG4107R73	Mate efflux family protein
TFKS16_0496	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
TFKS16_0497	ENOG4105D0M	Protease HtpX homolog
TFKS16_0498	ENOG4108NJY	Repeat protein
TFKS16_0501	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
TFKS16_0508	ENOG4105C0H	protease
TFKS16_0509	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TFKS16_0511	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
TFKS16_0512	ENOG4105DJV	ribulose-phosphate 3-epimerase
TFKS16_0524	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
TFKS16_0525	ENOG4105CYC	Transferase
TFKS16_0526	ENOG4105CV1	Transketolase (EC 2.2.1.1)
TFKS16_0527	ENOG4108YZG	isomerase
TFKS16_0530	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
TFKS16_0532	ENOG4105CJN	penicillin-binding protein
TFKS16_0533	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
TFKS16_0534	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
TFKS16_0535	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
TFKS16_0536	ENOG4105CNI	cell division protein FtsW
TFKS16_0537	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
TFKS16_0538	ENOG4105DFU	Cell wall formation (By similarity)
TFKS16_0540	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
TFKS16_0541	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
TFKS16_0542	ENOG4105KTH	gatB Yqey
TFKS16_0544	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0546	ENOG4105EN6	Membrane
TFKS16_0550	ENOG4105BZS	acriflavin resistance protein
TFKS16_0554	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
TFKS16_0557	ENOG4105CZH	peptidase
TFKS16_0558	ENOG4105K64	Glycosyl transferase, family 2
TFKS16_0564	ENOG4105C3F	Signal peptidase i
TFKS16_0573	ENOG4105C3F	Signal peptidase i
TFKS16_0583	ENOG4108IQE	Amp-dependent synthetase and ligase
TFKS16_0584	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TFKS16_0592	ENOG41080R2	UPF0102 protein
TFKS16_0596	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
TFKS16_0597	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
TFKS16_0598	ENOG4105RGC	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
TFKS16_0599	ENOG4107Z65	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
TFKS16_0601	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
TFKS16_0603	ENOG41082MC	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
TFKS16_0604	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
TFKS16_0607	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
TFKS16_0608	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
TFKS16_0613	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
TFKS16_0617	ENOG4105CFG	Acts as a chaperone (By similarity)
TFKS16_0619	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TFKS16_0637	ENOG4105CB5	ATP-dependent DNA helicase recG
TFKS16_0642	ENOG4105MZU	cell filamentation protein
TFKS16_0643	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
TFKS16_0649	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
TFKS16_0650	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
TFKS16_0651	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
TFKS16_0656	ENOG41088YA	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity)
TFKS16_0660	ENOG4105CAK	Cell division ATP-binding protein ftsE
TFKS16_0661	ENOG4105CFH	Aspartokinase
TFKS16_0662	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
TFKS16_0666	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
TFKS16_0667	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0669	ENOG41061MV	Arylsulfatase
TFKS16_0673	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TFKS16_0674	ENOG4105CSA	Coproporphyrinogen iii oxidase
TFKS16_0679	ENOG4105DHJ	ABC, transporter
TFKS16_0680	ENOG4108ZT0	50S ribosomal protein l17
TFKS16_0681	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TFKS16_0682	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
TFKS16_0683	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
TFKS16_0684	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TFKS16_0685	ENOG410864M	50S ribosomal protein L36
TFKS16_0686	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
TFKS16_0688	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
TFKS16_0689	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
TFKS16_0690	ENOG41084HK	50S ribosomal protein L30
TFKS16_0691	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
TFKS16_0692	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
TFKS16_0693	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
TFKS16_0694	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
TFKS16_0695	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
TFKS16_0696	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TFKS16_0697	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
TFKS16_0698	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
TFKS16_0699	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
TFKS16_0700	ENOG41062E3	50S ribosomal protein L29
TFKS16_0701	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
TFKS16_0702	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
TFKS16_0704	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
TFKS16_0705	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TFKS16_0706	ENOG41082S5	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
TFKS16_0707	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
TFKS16_0708	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
TFKS16_0709	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
TFKS16_0710	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TFKS16_0711	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
TFKS16_0712	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
TFKS16_0714	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
TFKS16_0717	ENOG4105DU6	RNA polymerase
TFKS16_0718	ENOG4105C9U	ATP-dependent DNA helicase RecQ
TFKS16_0726	ENOG4105CUT	histidyl-tRNA synthetase
TFKS16_0728	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
TFKS16_0731	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
TFKS16_0732	ENOG4108S0S	Nucleotidyl transferase
TFKS16_0735	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0739	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
TFKS16_0744	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
TFKS16_0751	ENOG4107V87	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity)
TFKS16_0752	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
TFKS16_0753	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
TFKS16_0754	ENOG4105C9U	ATP-dependent DNA helicase RecQ
TFKS16_0755	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
TFKS16_0757	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
TFKS16_0760	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
TFKS16_0761	ENOG4108IUZ	ABC transporter
TFKS16_0763	ENOG4105C10	Electron transfer flavoprotein
TFKS16_0764	ENOG4105BZJ	Electron transfer flavoprotein
TFKS16_0765	ENOG4105C1G	acyl-Coa dehydrogenase
TFKS16_0766	ENOG4107SG5	Dehydrogenase
TFKS16_0767	ENOG4107S8T	NAD-dependent 4-hydroxybutyrate dehydrogenase
TFKS16_0768	ENOG4105CYC	Transferase
TFKS16_0775	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
TFKS16_0776	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
TFKS16_0777	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
TFKS16_0784	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
TFKS16_0785	ENOG4105CA9	Pyruvate kinase
TFKS16_0789	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0793	ENOG4105H4N	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
TFKS16_0794	ENOG4105D60	lipoprotein releasing system transmembrane protein
TFKS16_0795	ENOG4105FDK	ABC transporter
TFKS16_0798	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
TFKS16_0802	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
TFKS16_0805	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
TFKS16_0806	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
TFKS16_0808	ENOG4105MJ2	Competence protein
TFKS16_0809	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
TFKS16_0810	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
TFKS16_0814	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
TFKS16_0818	ENOG4108JJA	ABC, transporter
TFKS16_0826	ENOG4105C3G	gtp-binding protein
TFKS16_0828	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0833	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0841	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0846	ENOG4105C0P	Mg chelatase subunit ChlI
TFKS16_0847	ENOG4105D7N	magnesium and cobalt transport protein CorA
TFKS16_0848	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
TFKS16_0850	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TFKS16_0857	ENOG4105CNT	hydrolase family 2
TFKS16_0858	ENOG4105DXN	mazG family
TFKS16_0866	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
TFKS16_0867	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
TFKS16_0868	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
TFKS16_0870	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
TFKS16_0871	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
TFKS16_0872	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
TFKS16_0874	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
TFKS16_0876	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
TFKS16_0877	ENOG4105C26	Dehydrogenase
TFKS16_0887	ENOG4105CFP	Peptidase U32
TFKS16_0890	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
TFKS16_0891	ENOG4105EEI	dihydropteroate synthase
TFKS16_0894	ENOG4108IJ2	phosphate acetyltransferase
TFKS16_0895	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
TFKS16_0899	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
TFKS16_0900	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
TFKS16_0908	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
TFKS16_0909	ENOG4105C3F	Signal peptidase i
TFKS16_0915	ENOG4105E6M	Sulphatase-modifying factor protein
TFKS16_0918	ENOG4108WBT	adenosyltransferase
TFKS16_0929	ENOG41086VD	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
TFKS16_0932	ENOG41084I7	Alpha-galactosidase. Removes both branched alpha-1,3- linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures
TFKS16_0935	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
TFKS16_0936	ENOG4105UYK	outer membrane protein a
TFKS16_0940	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0952	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
TFKS16_0961	ENOG4107GFK	fumarate
TFKS16_0964	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
TFKS16_0968	ENOG4105E6M	Sulphatase-modifying factor protein
TFKS16_0971	ENOG4108Q9V	regulatoR
TFKS16_0979	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0985	ENOG4105TT1	Ragb susd domain-containing protein
TFKS16_0986	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_0987	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
TFKS16_0992	ENOG4105C12	Phosphoribosylglycinamide synthetase
TFKS16_0994	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
TFKS16_1010	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
TFKS16_1018	ENOG4105CTQ	phosphohexokinase
TFKS16_1019	ENOG4105D2H	Uronic isomerase
TFKS16_1020	ENOG4105EAM	Na Pi-cotransporter
TFKS16_1022	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
TFKS16_1024	ENOG4105ENH	Sulfatase
TFKS16_1025	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
TFKS16_1026	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
TFKS16_1028	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
TFKS16_1030	ENOG41060GT	Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity)
TFKS16_1032	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
TFKS16_1034	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
TFKS16_1039	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
TFKS16_1042	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
TFKS16_1048	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
TFKS16_1049	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
TFKS16_1050	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
TFKS16_1051	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TFKS16_1052	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
TFKS16_1057	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
TFKS16_1058	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
TFKS16_1059	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
TFKS16_1061	ENOG4108KPZ	tonB-dependent Receptor
TFKS16_1062	ENOG4105CGH	5'-nucleotidase
TFKS16_1063	ENOG4105CTQ	phosphohexokinase
TFKS16_1066	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
TFKS16_1067	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
TFKS16_1068	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
TFKS16_1069	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
TFKS16_1076	ENOG4105DNX	Dna topoisomerase iv (Subunit b)
TFKS16_1077	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
TFKS16_1078	ENOG4105CN1	protease
TFKS16_1081	ENOG4105CK5	oxidoreductase
TFKS16_1084	ENOG4108IAJ	Nad-dependent epimerase dehydratase
TFKS16_1085	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
TFKS16_1087	ENOG4105CHR	reductase
TFKS16_1093	ENOG4105D2T	synthase
TFKS16_1094	ENOG4107SE4	UDP-N-acetylglucosamine 2-epimerase
TFKS16_1097	ENOG4105F0R	Cytidylyltransferase
TFKS16_1099	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
TFKS16_1104	ENOG4105CAQ	asparagine synthetase
TFKS16_1105	ENOG4105CB5	ATP-dependent DNA helicase recG
TFKS16_1108	ENOG4107R3N	Filamentation induced by cAMP protein fic
TFKS16_1109	ENOG4108IJ1	Dehydrogenase
TFKS16_1111	ENOG4108NMT	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity)
TFKS16_1113	ENOG4105CPK	Glycosyl transferase (Group 1
TFKS16_1118	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TFKS16_1119	ENOG4105CIN	aminoacyl-histidine dipeptidase
TFKS16_1122	ENOG4105C2X	Arabinose 5-phosphate isomerase
TFKS16_1124	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
TFKS16_1131	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_1143	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TFKS16_1146	ENOG4105DTQ	mandelate racemase muconate lactonizing
TFKS16_1151	ENOG4105C5Z	peptidase
TFKS16_1152	ENOG4108ZJ4	polysaccharide deacetylase
TFKS16_1155	ENOG4105EAH	synthase
TFKS16_1156	ENOG4105C2M	dna polymerase I
TFKS16_1157	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
TFKS16_1158	ENOG4105C2W	permease
TFKS16_1160	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
TFKS16_1161	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
TFKS16_1165	ENOG4105DJT	lAO AO transport system ATPase
TFKS16_1166	ENOG4105DKQ	ROK family
TFKS16_1167	ENOG4105EYH	Exonuclease
TFKS16_1168	ENOG4107RH8	nuclease SbcCD subunit D
TFKS16_1181	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
TFKS16_1182	ENOG4105DG6	mannose-6-phosphate isomerase
TFKS16_1184	ENOG4105TT1	Ragb susd domain-containing protein
TFKS16_1185	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_1188	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
TFKS16_1189	ENOG4108ZVT	methylmalonyl-coA epimerase
TFKS16_1190	ENOG4107QX3	carboxylase
TFKS16_1192	ENOG4106063	Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit
TFKS16_1193	ENOG4105D9Q	decarboxylase (Beta subunit)
TFKS16_1194	ENOG4108VVK	transcriptional Regulator, AsnC
TFKS16_1199	ENOG4105F8V	Hydrolase, tatD family
TFKS16_1203	ENOG4105CAT	Cytidine monophosphate kinase
TFKS16_1204	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
TFKS16_1207	ENOG4108IQE	Amp-dependent synthetase and ligase
TFKS16_1210	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
TFKS16_1211	ENOG4108JYZ	YitT family
TFKS16_1212	ENOG4105C8T	Leucyl-tRNA synthetase
TFKS16_1214	ENOG41080AX	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
TFKS16_1215	ENOG4108JIC	nucleoside recognition domain protein
TFKS16_1216	ENOG4105C5I	Dehydrogenase
TFKS16_1218	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
TFKS16_1229	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
TFKS16_1231	ENOG4105K8N	protein family UPF0079, ATPase
TFKS16_1232	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
TFKS16_1235	ENOG4105JVQ	RNA Polymerase
TFKS16_1241	ENOG41083B3	HAD-superfamily subfamily IB hydrolase
TFKS16_1245	ENOG4105E4P	ATPase (AAA
TFKS16_1246	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
TFKS16_1250	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
TFKS16_1251	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
TFKS16_1257	ENOG4108RQS	Two component transcriptional regulator (Winged helix family
TFKS16_1279	ENOG4105CXT	aspartate transcarbamylase
TFKS16_1280	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
TFKS16_1284	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TFKS16_1285	ENOG4105CEV	competence damage-inducible protein
TFKS16_1286	ENOG4105CVG	Homoserine O-transsuccinylase
TFKS16_1287	ENOG4105CFP	Peptidase U32
TFKS16_1288	ENOG4105C3R	Methionine synthase
TFKS16_1298	ENOG4108RWN	rrna methyltransferase
TFKS16_1302	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
TFKS16_1303	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
TFKS16_1304	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TFKS16_1306	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TFKS16_1307	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
TFKS16_1310	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
TFKS16_1311	ENOG4105DG6	mannose-6-phosphate isomerase
TFKS16_1312	ENOG4105CIG	ABC transporter
TFKS16_1323	ENOG4105E0X	reductase
TFKS16_1324	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
TFKS16_1326	ENOG4105DIJ	Phosphoethanolamine transferase
TFKS16_1327	ENOG4105C79	DNA protecting protein DprA
TFKS16_1336	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
TFKS16_1338	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
TFKS16_1339	ENOG4105C8J	)-transporter
TFKS16_1341	ENOG4108U5N	UPF0316 protein
TFKS16_1342	ENOG4105D6F	Phosphatase
TFKS16_1344	ENOG4105SBG	acid phosphatase
TFKS16_1347	ENOG4105QNR	S1 RNA binding domain protein
TFKS16_1351	ENOG4105C84	Histidine ammonia-lyase
TFKS16_1352	ENOG410908R	Methenyltetrahydrofolate cyclohydrolase
TFKS16_1354	ENOG4105CI2	imidazolone-5-propionate hydrolase
TFKS16_1355	ENOG4105CCS	Glutamate formiminotransferase
TFKS16_1357	ENOG4105CGP	Urocanate hydratase
TFKS16_1358	ENOG4105EPC	oxidoreductase
TFKS16_1361	ENOG41061MV	Arylsulfatase
TFKS16_1363	ENOG4107QZC	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
TFKS16_1366	ENOG4105D49	3-dehydroquinate synthase
TFKS16_1367	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TFKS16_1368	ENOG4105DR5	peptidase
TFKS16_1374	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
TFKS16_1375	ENOG41068JE	domain protein
TFKS16_1377	ENOG4105FA0	parb-like partition protein
TFKS16_1378	ENOG4107QJE	Chromosome Partitioning Protein
TFKS16_1380	ENOG4105CN1	protease
TFKS16_1382	ENOG4105DF5	DNA topoisomerase IV, subunit A
TFKS16_1386	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
TFKS16_1389	ENOG4108IUX	(ABC) transporter
TFKS16_1392	ENOG4105C84	Histidine ammonia-lyase
TFKS16_1393	ENOG4105DZS	Phenylacetate-CoA ligase
TFKS16_1403	ENOG4105CG3	alpha amylase, catalytic region
TFKS16_1404	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
TFKS16_1406	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
TFKS16_1409	ENOG4105D05	Receptor
TFKS16_1418	ENOG41090HT	Inherit from COG: transposase
TFKS16_1423	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
TFKS16_1425	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TFKS16_1427	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TFKS16_1429	ENOG4108I0C	methyltransferase
TFKS16_1432	ENOG4105BZ1	(ABC) transporter
TFKS16_1434	ENOG4105BZ1	(ABC) transporter
TFKS16_1435	ENOG4105CSV	Glutaminase
TFKS16_1445	ENOG4105C4X	radical SAM domain protein
TFKS16_1449	ENOG4105C75	arginyL-tRNA synthetase
TFKS16_1451	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
TFKS16_1460	ENOG4105N5T	Radical SAM Protein
TFKS16_1462	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
TFKS16_1467	ENOG4105CHM	Aminotransferase
TFKS16_1468	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
TFKS16_1472	ENOG41090IP	Required for maturation of 30S ribosomal subunits (By similarity)
TFKS16_1473	ENOG4105CHV	Transcription elongation factor NusA
TFKS16_1474	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
TFKS16_1482	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
TFKS16_1483	ENOG4105CHM	Aminotransferase
TFKS16_1489	ENOG4105C9B	Cysteine desulfurase
TFKS16_1492	ENOG4105K8R	UPF0145 protein
TFKS16_1493	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
TFKS16_1494	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
TFKS16_1496	ENOG4108Z86	Glutamine amidotransferase
TFKS16_1497	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
TFKS16_1511	ENOG4105RA3	Binds directly to 16S ribosomal RNA (By similarity)
TFKS16_1514	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_1515	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_1519	ENOG4105K63	Thioredoxin
TFKS16_1520	ENOG4105C0B	DNA polymerase III (alpha subunit)
TFKS16_1525	ENOG4105K5M	30s ribosomal protein S16
TFKS16_1526	ENOG4105NGQ	Thioredoxin
TFKS16_1529	ENOG4105C9U	ATP-dependent DNA helicase RecQ
TFKS16_1530	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
TFKS16_1533	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
TFKS16_1535	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
TFKS16_1537	ENOG4105EJQ	L-serine dehydratase
TFKS16_1538	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
TFKS16_1539	ENOG4105CSM	endonuclease III
TFKS16_1540	ENOG4107RAN	Peptidase, M16
TFKS16_1548	ENOG4105E2R	ROK family
TFKS16_1550	ENOG4105NGQ	Thioredoxin
TFKS16_1559	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
TFKS16_1560	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
TFKS16_1561	ENOG4105DQU	oxidoreductase, subunit beta
TFKS16_1562	ENOG4107RJ9	Cell division protein FtsX
TFKS16_1564	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
TFKS16_1565	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
TFKS16_1566	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
TFKS16_1567	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TFKS16_1577	ENOG4105C87	Aminotransferase class I and II
TFKS16_1578	ENOG4105EMN	RNA polymerase sigma factor
TFKS16_1580	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
TFKS16_1582	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
TFKS16_1584	ENOG4105CI3	gtp-binding protein typa
TFKS16_1585	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
TFKS16_1586	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
TFKS16_1591	ENOG4105C4M	(Ubiquinol oxidase) subunit I
TFKS16_1593	ENOG410904A	RNA polymerase
TFKS16_1595	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_1597	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
TFKS16_1600	ENOG4105C1V	Peptidase, M16
TFKS16_1603	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TFKS16_1606	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
TFKS16_1608	ENOG4105CNW	domain protein
TFKS16_1609	ENOG4107QZC	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
TFKS16_1610	ENOG4105DGA	Diaminopimelate dehydrogenase
TFKS16_1612	ENOG4105C8Y	Acetylornithine aminotransferase
TFKS16_1613	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
TFKS16_1614	ENOG4105CDH	Citrulline--aspartate ligase
TFKS16_1616	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
TFKS16_1622	ENOG4107G43	radical SAM domain protein
TFKS16_1625	ENOG4105CJ1	ABC, transporter
TFKS16_1628	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
TFKS16_1629	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
TFKS16_1630	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
TFKS16_1631	ENOG4106H78	methyltransferase
TFKS16_1639	ENOG4105PAD	Hydrolase
TFKS16_1642	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
TFKS16_1643	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
TFKS16_1644	ENOG4105CIH	Imidazole acetol-phosphate transaminase
TFKS16_1645	ENOG4105KME	endoribonuclease L-psp
TFKS16_1647	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
TFKS16_1648	ENOG4105D1H	recombination factor protein RarA
TFKS16_1653	ENOG4108Z6B	deaminase
TFKS16_1656	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
TFKS16_1658	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
TFKS16_1659	ENOG4105CDY	transcriptional regulatory protein
TFKS16_1664	ENOG4105C2N	RNA methyltransferase TrmH family group 3
TFKS16_1665	ENOG4107QKV	phosphomannomutase
TFKS16_1666	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
TFKS16_1667	ENOG4105K46	50S ribosomal protein l27
TFKS16_1668	ENOG4107TT5	NLP P60 protein
TFKS16_1669	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
TFKS16_1670	ENOG4107RN3	metallophosphoesterase
TFKS16_1676	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
TFKS16_1679	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
TFKS16_1682	ENOG4107QKA	exodeoxyribonuclease V beta
TFKS16_1683	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
TFKS16_1684	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
TFKS16_1686	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
TFKS16_1696	ENOG4105CGH	5'-nucleotidase
TFKS16_1709	ENOG4105E2D	ec 3.2.1.52
TFKS16_1710	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
TFKS16_1713	ENOG41060VI	Involved in DNA repair and RecF pathway recombination (By similarity)
TFKS16_1716	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
TFKS16_1718	ENOG4105PNM	synthesis protein
TFKS16_1719	ENOG4108Z0R	Transferase
TFKS16_1720	ENOG41083X6	30S ribosomal protein S21
TFKS16_1721	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TFKS16_1725	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
TFKS16_1728	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
TFKS16_1729	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
TFKS16_1730	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
TFKS16_1731	ENOG4107VNI	ribosomal protein l10
TFKS16_1732	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
TFKS16_1733	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TFKS16_1734	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TFKS16_1735	ENOG4105D7A	ATP-binding protein
TFKS16_1738	ENOG4105E4F	Isochorismate synthase
TFKS16_1739	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
TFKS16_1740	ENOG4108IPT	Naphthoate synthase
TFKS16_1741	ENOG4105DIA	mandelate racemase muconate lactonizing
TFKS16_1745	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TFKS16_1767	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
TFKS16_1777	ENOG4107R51	Glycosyl transferase, family 2
TFKS16_1781	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
TFKS16_1783	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
TFKS16_1785	ENOG4105J5G	Transferase hexapeptide repeat containing protein
TFKS16_1786	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
TFKS16_1792	ENOG4107QUV	Domain protein
TFKS16_1795	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
TFKS16_1802	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_1805	ENOG4105EMU	Dehydrogenase
TFKS16_1808	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
TFKS16_1809	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TFKS16_1811	ENOG4108YZY	peptidylprolyl cis-trans isomerase
TFKS16_1812	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
TFKS16_1813	ENOG4105C0H	protease
TFKS16_1816	ENOG4105DZP	Membrane-associated zinc metalloprotease
TFKS16_1818	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
TFKS16_1819	ENOG41063SB	peptidase
TFKS16_1820	ENOG4107YAY	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
TFKS16_1823	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
TFKS16_1824	ENOG4105BZM	domain protein
TFKS16_1827	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
TFKS16_1829	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
TFKS16_1832	ENOG4105C5H	ABC transporter
TFKS16_1833	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TFKS16_1834	ENOG4105CE1	Ferrous iron transport protein b
TFKS16_1836	ENOG4108HRK	Histidine kinase
TFKS16_1837	ENOG4105DY9	regulatoR
TFKS16_1850	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
TFKS16_1856	ENOG4105CTK	cobaltochelatase, cobn subunit
TFKS16_1857	ENOG4105D05	Receptor
TFKS16_1858	ENOG4105D05	Receptor
TFKS16_1862	ENOG4107QYD	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
TFKS16_1863	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
TFKS16_1867	ENOG4105EHZ	conserved protein UCP016719
TFKS16_1868	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
TFKS16_1869	ENOG4108UJD	30S ribosomal protein S9
TFKS16_1870	ENOG4105CE9	30S ribosomal protein S2
TFKS16_1871	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
TFKS16_1881	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_1889	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
TFKS16_1891	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
TFKS16_1896	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
TFKS16_1897	ENOG4107RH7	Nicotinate phosphoribosyltransferase
TFKS16_1898	ENOG4105C5H	ABC transporter
TFKS16_1901	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
TFKS16_1908	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
TFKS16_1911	ENOG4105EHZ	conserved protein UCP016719
TFKS16_1913	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
TFKS16_1914	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
TFKS16_1915	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
TFKS16_1916	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
TFKS16_1917	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
TFKS16_1918	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
TFKS16_1920	ENOG4105DR5	peptidase
TFKS16_1922	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
TFKS16_1923	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TFKS16_1924	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
TFKS16_1926	ENOG4108JJB	ABC transporter
TFKS16_1928	ENOG4105KHA	Glyoxalase Bleomycin resistance protein (Dioxygenase
TFKS16_1931	ENOG4105CKK	Glycosyl transferase, family 2
TFKS16_1933	ENOG4107RJ1	sodium solute
TFKS16_1934	ENOG4105CT7	inner membrane cred family protein
TFKS16_1942	ENOG4105DR9	pseudouridine synthase
TFKS16_1944	ENOG4105CHR	reductase
TFKS16_1945	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
TFKS16_1951	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
TFKS16_1952	ENOG41090EK	ompa motb domain protein
TFKS16_1956	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
TFKS16_1957	ENOG41072GX	Peptidase M22 Glycoprotease
TFKS16_1967	ENOG4107SCR	N-acetylneuraminate lyase
TFKS16_1969	ENOG4108I5G	Major Facilitator superfamily
TFKS16_1970	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_1973	ENOG4105E2D	ec 3.2.1.52
TFKS16_1978	ENOG4105E0K	tonB-dependent siderophore receptor
TFKS16_1979	ENOG4107PPM	cobalt chelatase
TFKS16_1982	ENOG4105D05	Receptor
TFKS16_1983	ENOG4105CJ2	(LipO)protein
TFKS16_1988	ENOG4105CTJ	Metal Dependent Phosphohydrolase
TFKS16_2010	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
TFKS16_2016	ENOG4105QIB	mu-like prophage Flumu protein gp29
TFKS16_2020	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
TFKS16_2023	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
TFKS16_2040	ENOG4105C4X	radical SAM domain protein
TFKS16_2054	ENOG4105CS9	pantothenic acid kinase
TFKS16_2058	ENOG4105CJ1	ABC, transporter
TFKS16_2059	ENOG4105CJ1	ABC, transporter
TFKS16_2060	ENOG4107QWP	ABC-2 type transporter
TFKS16_2064	ENOG4106MPV	outer membrane protein SusE
TFKS16_2066	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_2069	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
TFKS16_2071	ENOG4107SH3	glycosyl transferase, family 39
TFKS16_2073	ENOG4105VCQ	rubredoxin
TFKS16_2074	ENOG4105C5Q	Transcriptional regulator
TFKS16_2076	ENOG4105D64	Mechanosensitive ion channel
TFKS16_2077	ENOG4105CUZ	uba thif-type nad fad binding protein
TFKS16_2079	ENOG4105EP8	Glycosyl Hydrolase Family 88
TFKS16_2080	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_2082	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
TFKS16_2084	ENOG4105CBG	Sulfatase
TFKS16_2087	ENOG4105CHR	reductase
TFKS16_2089	ENOG4105DPW	Major facilitator superfamily MFS_1
TFKS16_2093	ENOG4107RBB	ABC transporter, permease
TFKS16_2111	ENOG4107SVC	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
TFKS16_2114	ENOG4105CU9	asparagine synthetase A
TFKS16_2116	ENOG4108DWA	Nad synthetase
TFKS16_2117	ENOG4105D78	K07001 NTE family protein
TFKS16_2119	ENOG4105WPN	DNA integration recombination invertion protein
TFKS16_2134	ENOG410695F	Crispr-associated protein, Csm1 family
TFKS16_2136	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
TFKS16_2138	ENOG4105G15	CRISPR-associated RAMP protein, Csm5 family
TFKS16_2141	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
TFKS16_2142	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
TFKS16_2147	ENOG41090A1	ferritin
TFKS16_2148	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TFKS16_2151	ENOG4105C4R	Atp-dependent dna helicase
TFKS16_2152	ENOG4105K70	DNA-binding protein
TFKS16_2153	ENOG4105KRF	dihydroneopterin aldolase
TFKS16_2155	ENOG4107S1W	4-alpha-glucanotransferase
TFKS16_2159	ENOG4105KNE	Phosphatidate cytidylyltransferase
TFKS16_2160	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
TFKS16_2166	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_2170	ENOG4105EA8	2-Nitropropane dioxygenase
TFKS16_2172	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
TFKS16_2173	ENOG4108IAB	Phoh family
TFKS16_2175	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
TFKS16_2184	ENOG4105ENX	hydrolase
TFKS16_2192	ENOG4105NAE	bifunctional deaminase-reductase domain protein
TFKS16_2194	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TFKS16_2196	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
TFKS16_2200	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
TFKS16_2201	ENOG4105C2N	RNA methyltransferase TrmH family group 3
TFKS16_2202	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
TFKS16_2203	ENOG4105VJV	50s ribosomal protein L35
TFKS16_2204	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
TFKS16_2205	ENOG4105C22	threonyL-tRNA synthetase
TFKS16_2207	ENOG4105CIN	aminoacyl-histidine dipeptidase
TFKS16_2210	ENOG4105CE4	GlcNAc 6-P deacetylase
TFKS16_2216	ENOG4105CNT	hydrolase family 2
TFKS16_2217	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
TFKS16_2220	ENOG4105FA2	dna polymerase iii
TFKS16_2221	ENOG4105SYT	Methylenetetrahydrofolate reductase
TFKS16_2223	ENOG4107QI1	Mate efflux family protein
TFKS16_2225	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_2230	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
TFKS16_2233	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
TFKS16_2234	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TFKS16_2235	ENOG4105E3Q	saccharopine dehydrogenase
TFKS16_2238	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
TFKS16_2239	ENOG4108PBI	Polysaccharide metabolism
TFKS16_2246	ENOG4105CNA	YD repeat protein
TFKS16_2247	ENOG4105CNA	YD repeat protein
TFKS16_2249	ENOG4105CNA	YD repeat protein
TFKS16_2250	ENOG4105CNA	YD repeat protein
TFKS16_2271	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
TFKS16_2272	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TFKS16_2274	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
TFKS16_2289	ENOG4105EKQ	RNA-directed DNA polymerase
TFKS16_2304	ENOG4105DDY	UPF0142 protein ycaO
TFKS16_2306	ENOG4105DDY	UPF0142 protein ycaO
TFKS16_2307	ENOG4105C4X	radical SAM domain protein
TFKS16_2308	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
TFKS16_2314	ENOG4105EKQ	RNA-directed DNA polymerase
TFKS16_2322	ENOG4105VTR	Integrase
TFKS16_2327	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
TFKS16_2330	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TFKS16_2332	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
TFKS16_2335	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_2341	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
TFKS16_2344	ENOG4105DR5	peptidase
TFKS16_2347	ENOG4105CP7	Triose-phosphate isomerase
TFKS16_2349	ENOG4105EUJ	GTP cyclohydrolase i
TFKS16_2350	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
TFKS16_2353	ENOG4105DZW	Dipeptidase
TFKS16_2356	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
TFKS16_2358	ENOG4108V1T	peptidylprolyl cis-trans isomerase
TFKS16_2359	ENOG4108V1T	peptidylprolyl cis-trans isomerase
TFKS16_2368	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_2371	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
TFKS16_2372	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
TFKS16_2375	ENOG4105CD3	dihydroorotase
TFKS16_2376	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
TFKS16_2377	ENOG4105F32	YngK protein
TFKS16_2378	ENOG4108IAJ	Nad-dependent epimerase dehydratase
TFKS16_2381	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
TFKS16_2383	ENOG4105E9H	Lytic Murein transglycosylase
TFKS16_2384	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
TFKS16_2386	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
TFKS16_2389	ENOG4105DC7	peptidase M24
TFKS16_2390	ENOG4105G6Z	alkaline phosphatase
TFKS16_2406	ENOG4107VE4	peptidase S8 and S53, subtilisin, kexin, sedolisin
TFKS16_2421	ENOG4105F32	YngK protein
TFKS16_2423	ENOG4105C3M	thioredoxin reductase
TFKS16_2425	ENOG4105CNU	cell division protein FtsK
TFKS16_2426	ENOG4105C9M	aspartyl-trna synthetase
TFKS16_2427	ENOG4105EGD	dinuclear metal center protein, YbgI family
TFKS16_2429	ENOG4107THF	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
TFKS16_2430	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
TFKS16_2432	ENOG4105D3R	alkyl hydroperoxide reductase
TFKS16_2434	ENOG4105WH1	Two component transcriptional regulator luxr family
TFKS16_2436	ENOG4105D0C	transport protein
TFKS16_2440	ENOG4107QSA	Oxaloacetate decarboxylase
TFKS16_2442	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
TFKS16_2443	ENOG4107QR9	Iron-sulfur cluster binding protein
TFKS16_2452	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
TFKS16_2453	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
TFKS16_2454	ENOG410647Z	gliding motility-associated lipoprotein GldH
TFKS16_2455	ENOG4105MA4	psp1 domain protein
TFKS16_2456	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
TFKS16_2457	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
TFKS16_2459	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
TFKS16_2460	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
TFKS16_2471	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_2474	ENOG4105CMN	Methylmalonyl-coA mutase
TFKS16_2475	ENOG4105D5P	Methylmalonyl-coA mutase
TFKS16_2477	ENOG4105C5H	ABC transporter
TFKS16_2479	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
TFKS16_2480	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
TFKS16_2481	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
TFKS16_2482	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
TFKS16_2486	ENOG4107SVV	electron transport complex, RnfABCDGE type, B subunit
TFKS16_2487	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
TFKS16_2488	ENOG4105D6A	Electron transport complex
TFKS16_2489	ENOG4108UQQ	Electron transport complex
TFKS16_2490	ENOG4105DZB	Electron transport complex
TFKS16_2491	ENOG4105DGN	Electron transport complex
TFKS16_2499	ENOG4105C7N	Xanthine uracil vitamin C permease
TFKS16_2503	ENOG4105CBG	Sulfatase
TFKS16_2505	ENOG4108WBT	adenosyltransferase
TFKS16_2506	ENOG4105E4R	Precorrin-3B C17-methyltransferase
TFKS16_2507	ENOG4107XSI	cobalt-precorrin-6y C15-methyltransferase
TFKS16_2508	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
TFKS16_2509	ENOG4107UA7	cobalamin biosynthesis protein CbiD
TFKS16_2510	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
TFKS16_2517	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
TFKS16_2518	ENOG4105DFG	type I secretion outer membrane protein
TFKS16_2521	ENOG4105DUX	Transporter
TFKS16_2523	ENOG4107REN	Carbamoyltransferase
TFKS16_2526	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_2531	ENOG4105CMG	Carbohydrate kinase
TFKS16_2532	ENOG4105C93	Xylose Isomerase
TFKS16_2533	ENOG4107QNK	)-transporter
TFKS16_2536	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_2550	ENOG4107T6X	nag kinase
TFKS16_2551	ENOG4105CCT	upf0313 protein
TFKS16_2552	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
TFKS16_2553	ENOG4105C1J	atp-dependent rna helicase
TFKS16_2554	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
TFKS16_2565	ENOG4105CX6	glutaminyL-tRNA synthetase
TFKS16_2567	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
TFKS16_2568	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
TFKS16_2572	ENOG4105C3S	Mate efflux family protein
TFKS16_2577	ENOG4105BZU	Histidine kinase
TFKS16_2589	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TFKS16_2590	ENOG4105C5X	domain protein
TFKS16_2591	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
TFKS16_2594	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
TFKS16_2598	ENOG4108WIQ	phosphoesterase PA-phosphatase related protein
TFKS16_2602	ENOG4107QVM	von Willebrand factor, type A
TFKS16_2606	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
TFKS16_2608	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
TFKS16_2609	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
TFKS16_2610	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
TFKS16_2621	ENOG4105FYV	Amp nucleosidase
TFKS16_2625	ENOG4105C03	ribonuclease
TFKS16_2626	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
TFKS16_2629	ENOG4108UUM	single-stranded DNA-binding protein
TFKS16_2630	ENOG4108JU5	Magnesium and cobalt efflux protein
TFKS16_2638	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_2642	ENOG4105EXW	epimerase dehydratase
TFKS16_2643	ENOG4105YVM	Phosphoesterase, PA-phosphatase related
TFKS16_2652	ENOG4105EE0	oxidoreductase
TFKS16_2653	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
TFKS16_2654	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
TFKS16_2656	ENOG4105CKK	Glycosyl transferase, family 2
TFKS16_2658	ENOG4107T7F	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
TFKS16_2660	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
TFKS16_2663	ENOG4108UKJ	Cdp-alcohol phosphatidyltransferase
TFKS16_2667	ENOG4107QQG	Dehydrogenase
TFKS16_2669	ENOG4105E2X	shikimate dehydrogenase
TFKS16_2670	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TFKS16_2671	ENOG4107QWK	SAICAR synthetase
TFKS16_2675	ENOG4107RAQ	aminopeptidase
TFKS16_2687	ENOG4105CNT	hydrolase family 2
TFKS16_2689	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
TFKS16_2690	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_2693	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
TFKS16_2694	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TFKS16_2695	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
TFKS16_2700	ENOG4108ZF3	Phosphatase
TFKS16_2705	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_2709	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
TFKS16_2715	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
TFKS16_2719	ENOG4107YDW	inorganic pyrophosphatase EC 3.6.1.1
TFKS16_2726	ENOG4107UGT	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
TFKS16_2729	ENOG4105CN1	protease
TFKS16_2743	ENOG4108JUA	Transcriptional regulator
TFKS16_2746	ENOG4108RKS	Short-chain dehydrogenase reductase Sdr
TFKS16_2749	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
TFKS16_2751	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
TFKS16_2752	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
TFKS16_2758	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
TFKS16_2761	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
TFKS16_2762	ENOG4107ZNS	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
TFKS16_2763	ENOG4105D3Q	Sugar transferase
TFKS16_2768	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
TFKS16_2769	ENOG4105D60	lipoprotein releasing system transmembrane protein
TFKS16_2770	ENOG4105CHM	Aminotransferase
TFKS16_2772	ENOG4107QN2	dihydrolipoyl dehydrogenase
TFKS16_2774	ENOG4108UJU	UPF0301 protein
TFKS16_2775	ENOG4108IQK	o-acetylhomoserine
TFKS16_2776	ENOG4105RHA	ABC transporter, permease
TFKS16_2777	ENOG4108IUX	(ABC) transporter
TFKS16_2778	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
TFKS16_2780	ENOG4105WKZ	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
TFKS16_2782	ENOG4105E9M	CRISPR-associated protein, Csn1 family
TFKS16_2785	ENOG4105C6E	dna polymerase iii
TFKS16_2788	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
TFKS16_2791	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
TFKS16_2792	ENOG4108Z03	MAF-like protein
TFKS16_2793	ENOG4105C30	Nad-dependent epimerase dehydratase
TFKS16_2798	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
TFKS16_2799	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
TFKS16_2800	ENOG4105VEJ	Heat shock protein
TFKS16_2809	ENOG4105C3F	Signal peptidase i
TFKS16_2810	ENOG4105BZ1	(ABC) transporter
TFKS16_2813	ENOG4107KET	secretion protein, HlyD family
TFKS16_2816	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
TFKS16_2817	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_2821	ENOG4107S0N	DJ-1 family
TFKS16_2823	ENOG4109015	Biopolymer transport protein exbD tolR
TFKS16_2825	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
TFKS16_2826	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
TFKS16_2831	ENOG4105CM2	brancheD-chain amino acid aminotransferase
TFKS16_2837	ENOG4105D0C	transport protein
TFKS16_2853	ENOG4107S2Z	UPF0761 membrane protein
TFKS16_2855	ENOG4105CFH	Aspartokinase
TFKS16_2856	ENOG4105E3H	phosphoglycerate mutase
TFKS16_2858	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
TFKS16_2859	ENOG4105C25	Primosomal protein n'
TFKS16_2865	ENOG4108UVJ	appr-1-p processing domain protein
TFKS16_2867	ENOG4105WD1	Membrane
TFKS16_2868	ENOG4105IIU	Aminopeptidase
TFKS16_2870	ENOG4107Y03	Nitroreductase
TFKS16_2871	ENOG4105CEY	Amp-dependent synthetase and ligase
TFKS16_2879	ENOG4108Q5F	Tetr family transcriptional regulator
TFKS16_2890	ENOG4105E4P	ATPase (AAA
TFKS16_2894	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TFKS16_2927	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TFKS16_2929	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TFKS16_2936	ENOG4105KVH	Transcriptional regulator
TFKS16_2937	ENOG4105F5P	DNA-damage-inducible protein d
TFKS16_2940	ENOG410874W	AraC family transcriptional regulator
TFKS16_2941	ENOG4105C3S	Mate efflux family protein
TFKS16_2947	ENOG4105E4P	ATPase (AAA
TFKS16_2955	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
TFKS16_2964	ENOG4105VG0	50S ribosomal protein l34
TFKS16_2966	ENOG4105C34	Pseudouridine synthase
TFKS16_2967	ENOG4105CPF	Cell wall formation (By similarity)
TFKS16_2969	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
TFKS16_2970	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
TFKS16_2974	ENOG4105CNT	hydrolase family 2
TFKS16_2976	ENOG4105CZ7	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
TFKS16_2983	ENOG4105DMW	Dehydrogenase reductase
TFKS16_2987	ENOG4105D1Q	UPF0246 protein
TFKS16_2990	ENOG4105C27	TonB-dependent Receptor Plug
TFKS16_2998	ENOG41081WG	50s ribosomal protein l31
TFKS16_2999	ENOG4105D2N	Aldolase
TFKS16_3000	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
TFKS16_3005	ENOG4105DZ0	fad dependent oxidoreductase
TFKS16_3012	ENOG4105DR4	Methyltransferase
TFKS16_3015	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
TFKS16_3016	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
TFKS16_3017	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
TFKS16_3018	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
TFKS16_3019	ENOG4108JQC	penicillin-binding protein 1A
TFKS16_3020	ENOG4105CDU	Replicative dna helicase
TFKS16_3022	ENOG4105C5H	ABC transporter
TFKS16_3024	ENOG4105DC1	bifunctional purine biosynthesis protein purh
TFKS16_3029	ENOG4105CNI	cell division protein FtsW
TFKS16_3030	ENOG4105CRK	lysyL-tRNA synthetase
TFKS16_3031	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
TFKS16_3032	ENOG4107QP8	phosphohexose isomerase
TFKS16_3034	ENOG41080B9	Binds together with S18 to 16S ribosomal RNA (By similarity)
TFKS16_3035	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
TFKS16_3036	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
TFKS16_3037	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase