locus-tag	class	description
TFKS16_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TFKS16_0003	COG0335	large ribosomal subunit rRNA binding
TFKS16_0008	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TFKS16_0011	COG3590	peptidase
TFKS16_0014	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TFKS16_0015	COG1120	ATPase activity
TFKS16_0018	COG0543	2 iron, 2 sulfur cluster binding
TFKS16_0019	COG0167	dihydroorotate dehydrogenase activity
TFKS16_0022	COG1285	pathogenesis
TFKS16_0024	COG0101	tRNA pseudouridine synthase activity
TFKS16_0026	COG1797	cobyrinic acid a,c-diamide synthase activity
TFKS16_0027	COG5297	Belongs to the glycosyl hydrolase family 6
TFKS16_0027	COG3250	beta-galactosidase activity
TFKS16_0029	COG1629	transport
TFKS16_0029	COG4206	TonB-dependent receptor
TFKS16_0032	COG1629	transport
TFKS16_0032	COG4206	TonB-dependent receptor
TFKS16_0035	COG1215	transferase activity, transferring glycosyl groups
TFKS16_0037	COG2385	sporulation resulting in formation of a cellular spore
TFKS16_0037	COG2247	cell wall binding repeat
TFKS16_0038	COG2211	Major facilitator Superfamily
TFKS16_0039	COG3876	Protein conserved in bacteria
TFKS16_0042	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TFKS16_0043	COG0561	phosphatase activity
TFKS16_0056	COG0641	radical SAM
TFKS16_0058	COG3385	transposase activity
TFKS16_0075	COG3617	BRO family, N-terminal domain
TFKS16_0076	COG0175	sulfate reduction
TFKS16_0091	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TFKS16_0099	COG2274	protein secretion by the type I secretion system
TFKS16_0103	COG0438	transferase activity, transferring glycosyl groups
TFKS16_0109	COG2274	protein secretion by the type I secretion system
TFKS16_0117	COG1187	pseudouridine synthase activity
TFKS16_0122	COG1132	(ABC) transporter
TFKS16_0123	COG1132	(ABC) transporter
TFKS16_0125	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
TFKS16_0128	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TFKS16_0136	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TFKS16_0137	COG0543	2 iron, 2 sulfur cluster binding
TFKS16_0138	COG0493	'glutamate synthase
TFKS16_0139	COG3015	lipoprotein NlpE involved in copper resistance
TFKS16_0141	COG1051	belongs to the nudix hydrolase family
TFKS16_0142	COG1970	mechanosensitive ion channel activity
TFKS16_0143	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TFKS16_0145	COG2972	Histidine kinase
TFKS16_0145	COG0745	RESPONSE REGULATOR receiver
TFKS16_0150	COG4591	ABC-type transport system involved in lipoprotein release permease component
TFKS16_0150	COG1136	(ABC) transporter
TFKS16_0159	COG4191	Histidine kinase
TFKS16_0168	COG0438	transferase activity, transferring glycosyl groups
TFKS16_0170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TFKS16_0173	COG0237	dephospho-CoA kinase activity
TFKS16_0175	COG1862	Preprotein translocase
TFKS16_0176	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TFKS16_0178	COG0252	asparaginase activity
TFKS16_0182	COG4206	TonB-dependent receptor
TFKS16_0182	COG1629	transport
TFKS16_0188	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TFKS16_0192	COG1011	Hydrolase
TFKS16_0194	COG1595	DNA-templated transcription, initiation
TFKS16_0207	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TFKS16_0209	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TFKS16_0210	COG0235	Class ii aldolase
TFKS16_0212	COG4806	L-rhamnose isomerase
TFKS16_0213	COG1070	Carbohydrate kinase
TFKS16_0216	COG0442	prolyl-tRNA aminoacylation
TFKS16_0217	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TFKS16_0220	COG1704	LemA family
TFKS16_0221	COG0501	Belongs to the peptidase M48B family
TFKS16_0222	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TFKS16_0223	COG0126	phosphoglycerate kinase activity
TFKS16_0224	COG0534	Mate efflux family protein
TFKS16_0233	COG0484	heat shock protein binding
TFKS16_0234	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TFKS16_0235	COG1193	negative regulation of DNA recombination
TFKS16_0236	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TFKS16_0238	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TFKS16_0244	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TFKS16_0246	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TFKS16_0249	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TFKS16_0250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TFKS16_0253	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TFKS16_0257	COG2264	protein methyltransferase activity
TFKS16_0259	COG2197	response regulator
TFKS16_0261	COG1373	ATPase (AAA superfamily
TFKS16_0262	COG4804	nuclease activity
TFKS16_0267	COG3152	Membrane
TFKS16_0274	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TFKS16_0276	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TFKS16_0277	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TFKS16_0283	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
TFKS16_0284	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TFKS16_0288	COG4206	TonB-dependent receptor
TFKS16_0288	COG1629	transport
TFKS16_0290	COG3250	beta-galactosidase activity
TFKS16_0292	COG2431	L-lysine efflux transmembrane transporter activity
TFKS16_0293	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TFKS16_0294	COG3339	Conserved Protein
TFKS16_0297	COG0738	Major facilitator superfamily
TFKS16_0298	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TFKS16_0298	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TFKS16_0299	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TFKS16_0301	COG2885	chlorophyll binding
TFKS16_0302	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TFKS16_0302	COG1333	cytochrome c biogenesis protein
TFKS16_0303	COG1506	peptidase
TFKS16_0303	COG0823	Involved in the tonB-independent uptake of proteins
TFKS16_0305	COG3537	Alpha-1,2-mannosidase
TFKS16_0307	COG0534	Mate efflux family protein
TFKS16_0308	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TFKS16_0309	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TFKS16_0310	COG0297	glycogen (starch) synthase activity
TFKS16_0332	COG1561	YicC-like family, N-terminal region
TFKS16_0333	COG0194	GDP metabolic process
TFKS16_0334	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TFKS16_0336	COG0793	Belongs to the peptidase S41A family
TFKS16_0339	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TFKS16_0341	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TFKS16_0349	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TFKS16_0350	COG0659	secondary active sulfate transmembrane transporter activity
TFKS16_0354	COG1629	transport
TFKS16_0354	COG4206	TonB-dependent receptor
TFKS16_0360	COG0594	ribonuclease P activity
TFKS16_0361	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TFKS16_0362	COG0084	hydrolase, TatD family'
TFKS16_0379	COG2197	response regulator
TFKS16_0380	COG4585	Histidine kinase
TFKS16_0384	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TFKS16_0388	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TFKS16_0391	COG0584	glycerophosphoryl diester phosphodiesterase
TFKS16_0393	COG3475	LICD family
TFKS16_0396	COG0535	radical SAM domain protein
TFKS16_0402	COG3142	Participates in the control of copper homeostasis
TFKS16_0405	COG0556	nucleotide-excision repair
TFKS16_0407	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TFKS16_0408	COG3550	peptidyl-serine autophosphorylation
TFKS16_0409	COG3550	peptidyl-serine autophosphorylation
TFKS16_0410	COG1396	sequence-specific DNA binding
TFKS16_0421	COG4206	TonB-dependent receptor
TFKS16_0423	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TFKS16_0424	COG0569	domain protein
TFKS16_0425	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TFKS16_0427	COG0039	L-malate dehydrogenase activity
TFKS16_0430	COG0180	Tryptophanyl-tRNA synthetase
TFKS16_0434	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TFKS16_0435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TFKS16_0441	COG1629	transport
TFKS16_0441	COG4206	TonB-dependent receptor
TFKS16_0443	COG0823	Involved in the tonB-independent uptake of proteins
TFKS16_0443	COG1506	peptidase
TFKS16_0443	COG4946	Tricorn protease homolog
TFKS16_0445	COG4206	TonB-dependent receptor
TFKS16_0445	COG1629	transport
TFKS16_0450	COG3537	Alpha-1,2-mannosidase
TFKS16_0454	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TFKS16_0455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TFKS16_0457	COG1160	GTP binding
TFKS16_0458	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TFKS16_0460	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
TFKS16_0463	COG0438	transferase activity, transferring glycosyl groups
TFKS16_0465	COG0165	Argininosuccinate lyase
TFKS16_0467	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TFKS16_0469	COG2373	Large extracellular alpha-helical protein
TFKS16_0470	COG4953	penicillin-binding protein 1C
TFKS16_0472	COG0366	Alpha amylase catalytic
TFKS16_0474	COG1136	(ABC) transporter
TFKS16_0475	COG1136	(ABC) transporter
TFKS16_0475	COG0577	efflux transmembrane transporter activity
TFKS16_0481	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TFKS16_0482	COG0363	glucosamine-6-phosphate deaminase activity
TFKS16_0487	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TFKS16_0488	COG3250	beta-galactosidase activity
TFKS16_0490	COG0312	modulator of DNA gyrase
TFKS16_0494	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TFKS16_0495	COG0534	Mate efflux family protein
TFKS16_0496	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TFKS16_0497	COG0501	Belongs to the peptidase M48B family
TFKS16_0498	COG4886	Leucine-rich repeat (LRR) protein
TFKS16_0501	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TFKS16_0501	COG0519	Catalyzes the synthesis of GMP from XMP
TFKS16_0508	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_0509	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TFKS16_0511	COG0658	competence protein
TFKS16_0511	COG2333	competence protein COMEC
TFKS16_0512	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TFKS16_0514	COG1595	DNA-templated transcription, initiation
TFKS16_0524	COG0546	phosphoglycolate phosphatase activity
TFKS16_0525	COG0427	acetyl-CoA hydrolase
TFKS16_0526	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TFKS16_0527	COG0698	ribose 5-phosphate isomerase
TFKS16_0530	COG0275	rRNA processing
TFKS16_0532	COG0768	penicillin binding
TFKS16_0533	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TFKS16_0534	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TFKS16_0535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TFKS16_0536	COG0772	Belongs to the SEDS family
TFKS16_0537	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TFKS16_0538	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TFKS16_0541	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TFKS16_0542	COG1610	YqeY-like protein
TFKS16_0544	COG1629	transport
TFKS16_0544	COG4206	TonB-dependent receptor
TFKS16_0546	COG2860	membrane
TFKS16_0554	COG2255	four-way junction helicase activity
TFKS16_0557	COG3591	Belongs to the peptidase S1B family
TFKS16_0558	COG1216	Glycosyl transferase, family 2
TFKS16_0558	COG0463	Glycosyl transferase, family 2
TFKS16_0564	COG0681	Belongs to the peptidase S26 family
TFKS16_0573	COG0681	Belongs to the peptidase S26 family
TFKS16_0583	COG1022	Amp-dependent synthetase and ligase
TFKS16_0584	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TFKS16_0586	COG1215	transferase activity, transferring glycosyl groups
TFKS16_0592	COG0792	nuclease activity
TFKS16_0596	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TFKS16_0597	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TFKS16_0598	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TFKS16_0599	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TFKS16_0600	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TFKS16_0601	COG0356	it plays a direct role in the translocation of protons across the membrane
TFKS16_0603	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TFKS16_0604	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TFKS16_0607	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TFKS16_0608	COG1091	dTDP-4-dehydrorhamnose reductase activity
TFKS16_0611	COG0612	Peptidase, M16
TFKS16_0613	COG1696	Membrane protein involved in D-alanine export
TFKS16_0617	COG0443	Heat shock 70 kDa protein
TFKS16_0619	COG4974	Belongs to the 'phage' integrase family
TFKS16_0629	COG1476	TRANSCRIPTIONal
TFKS16_0647	COG5549	protein import
TFKS16_0647	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_0649	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TFKS16_0650	COG3386	PFAM SMP-30 Gluconolaconase
TFKS16_0651	COG0557	exoribonuclease II activity
TFKS16_0656	COG0778	Nitroreductase
TFKS16_0656	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
TFKS16_0660	COG2884	Cell division ATP-binding protein ftsE
TFKS16_0661	COG0527	aspartate kinase activity
TFKS16_0662	COG0019	diaminopimelate decarboxylase activity
TFKS16_0666	COG0673	inositol 2-dehydrogenase activity
TFKS16_0667	COG1629	transport
TFKS16_0667	COG4206	TonB-dependent receptor
TFKS16_0669	COG3119	arylsulfatase activity
TFKS16_0673	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TFKS16_0674	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TFKS16_0678	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TFKS16_0679	COG1127	ABC transporter
TFKS16_0680	COG0203	ribosomal protein L17
TFKS16_0681	COG0202	RNA polymerase activity
TFKS16_0682	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TFKS16_0683	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TFKS16_0684	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TFKS16_0685	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TFKS16_0686	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TFKS16_0688	COG0201	protein transport
TFKS16_0689	COG0200	Binds to the 23S rRNA
TFKS16_0690	COG1841	ribosomal large subunit assembly
TFKS16_0691	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TFKS16_0692	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TFKS16_0693	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TFKS16_0694	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TFKS16_0695	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TFKS16_0696	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TFKS16_0697	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TFKS16_0698	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TFKS16_0699	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TFKS16_0700	COG0255	Belongs to the universal ribosomal protein uL29 family
TFKS16_0701	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TFKS16_0702	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TFKS16_0704	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TFKS16_0705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TFKS16_0706	COG0089	rRNA binding
TFKS16_0707	COG0088	Forms part of the polypeptide exit tunnel
TFKS16_0708	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TFKS16_0709	COG0051	transcription antitermination factor activity, RNA binding
TFKS16_0710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TFKS16_0711	COG0049	tRNA binding
TFKS16_0712	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TFKS16_0714	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TFKS16_0717	COG1595	DNA-templated transcription, initiation
TFKS16_0718	COG0551	DNA topoisomerase type I activity
TFKS16_0718	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TFKS16_0719	COG3385	transposase activity
TFKS16_0726	COG0124	histidyl-tRNA synthetase
TFKS16_0728	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TFKS16_0732	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TFKS16_0735	COG1629	transport
TFKS16_0735	COG4206	TonB-dependent receptor
TFKS16_0739	COG0756	dUTP diphosphatase activity
TFKS16_0743	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TFKS16_0744	COG4206	TonB-dependent receptor
TFKS16_0751	COG0544	peptidyl-prolyl cis-trans isomerase activity
TFKS16_0752	COG0740	serine-type endopeptidase activity
TFKS16_0753	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TFKS16_0754	COG0514	ATP-dependent DNA helicase (RecQ)
TFKS16_0755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TFKS16_0757	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TFKS16_0760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TFKS16_0761	COG1137	ATPase activity
TFKS16_0763	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TFKS16_0764	COG2086	electron transfer activity
TFKS16_0765	COG1960	acyl-CoA dehydrogenase activity
TFKS16_0766	COG1012	belongs to the aldehyde dehydrogenase family
TFKS16_0767	COG1454	alcohol dehydrogenase
TFKS16_0768	COG0427	acetyl-CoA hydrolase
TFKS16_0775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TFKS16_0777	COG0617	tRNA 3'-terminal CCA addition
TFKS16_0778	COG1956	GAF domain-containing protein
TFKS16_0784	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TFKS16_0789	COG1629	transport
TFKS16_0789	COG4206	TonB-dependent receptor
TFKS16_0793	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TFKS16_0794	COG4591	ABC-type transport system involved in lipoprotein release permease component
TFKS16_0795	COG1121	(ABC) transporter
TFKS16_0798	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TFKS16_0802	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TFKS16_0805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TFKS16_0805	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TFKS16_0806	COG2890	protein-(glutamine-N5) methyltransferase activity
TFKS16_0810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TFKS16_0814	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TFKS16_0826	COG0012	GTP binding
TFKS16_0828	COG4206	TonB-dependent receptor
TFKS16_0828	COG1629	transport
TFKS16_0833	COG1629	transport
TFKS16_0833	COG4206	TonB-dependent receptor
TFKS16_0838	COG0463	Glycosyl transferase, family 2
TFKS16_0841	COG1629	transport
TFKS16_0841	COG4206	TonB-dependent receptor
TFKS16_0846	COG0606	chelatase, subunit chli
TFKS16_0847	COG0598	Magnesium transport protein CorA
TFKS16_0848	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TFKS16_0850	COG4974	Belongs to the 'phage' integrase family
TFKS16_0857	COG3250	beta-galactosidase activity
TFKS16_0858	COG3956	TIGRFAM MazG family protein
TFKS16_0866	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TFKS16_0867	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TFKS16_0868	COG0284	orotidine-5'-phosphate decarboxylase activity
TFKS16_0870	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TFKS16_0871	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TFKS16_0871	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TFKS16_0872	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TFKS16_0874	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TFKS16_0876	COG0813	purine-nucleoside phosphorylase activity
TFKS16_0877	COG1012	belongs to the aldehyde dehydrogenase family
TFKS16_0887	COG0826	peptidase U32
TFKS16_0890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TFKS16_0891	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TFKS16_0894	COG0280	phosphate acetyltransferase
TFKS16_0895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TFKS16_0898	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TFKS16_0899	COG1162	GTPase activity
TFKS16_0900	COG0233	cytoplasmic translational termination
TFKS16_0908	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TFKS16_0909	COG0681	Belongs to the peptidase S26 family
TFKS16_0915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TFKS16_0918	COG2096	Adenosyltransferase
TFKS16_0922	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TFKS16_0929	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TFKS16_0930	COG1028	Short-chain dehydrogenase reductase Sdr
TFKS16_0932	COG5434	Belongs to the glycosyl hydrolase 28 family
TFKS16_0935	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TFKS16_0936	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TFKS16_0936	COG2885	chlorophyll binding
TFKS16_0940	COG4206	TonB-dependent receptor
TFKS16_0940	COG1629	transport
TFKS16_0961	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TFKS16_0961	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TFKS16_0964	COG0423	glycine-tRNA ligase activity
TFKS16_0968	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TFKS16_0971	COG2197	response regulator
TFKS16_0979	COG1629	transport
TFKS16_0979	COG4206	TonB-dependent receptor
TFKS16_0985	COG0561	phosphatase activity
TFKS16_0986	COG1629	transport
TFKS16_0986	COG4206	TonB-dependent receptor
TFKS16_0987	COG2706	6-phosphogluconolactonase activity
TFKS16_0992	COG0151	Belongs to the GarS family
TFKS16_0994	COG2095	MarC family integral membrane protein
TFKS16_0998	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_0998	COG5549	protein import
TFKS16_1003	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_1003	COG5549	protein import
TFKS16_1008	COG5549	protein import
TFKS16_1008	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_1010	COG0714	Associated with various cellular activities
TFKS16_1018	COG0205	6-phosphofructokinase activity
TFKS16_1019	COG1904	glucuronate isomerase
TFKS16_1022	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TFKS16_1024	COG3119	arylsulfatase activity
TFKS16_1025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TFKS16_1026	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TFKS16_1028	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TFKS16_1030	COG2076	Multidrug Resistance protein
TFKS16_1032	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TFKS16_1034	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TFKS16_1039	COG2204	response regulator
TFKS16_1042	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TFKS16_1048	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TFKS16_1049	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TFKS16_1050	COG0509	glycine decarboxylation via glycine cleavage system
TFKS16_1052	COG1234	tRNA 3'-trailer cleavage
TFKS16_1057	COG1490	D-aminoacyl-tRNA deacylase activity
TFKS16_1058	COG0322	excinuclease ABC activity
TFKS16_1059	COG0445	tRNA wobble uridine modification
TFKS16_1062	COG0737	Belongs to the 5'-nucleotidase family
TFKS16_1063	COG0205	6-phosphofructokinase activity
TFKS16_1066	COG0571	ribonuclease III activity
TFKS16_1067	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TFKS16_1068	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TFKS16_1069	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TFKS16_1077	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TFKS16_1078	COG0793	Belongs to the peptidase S41A family
TFKS16_1078	COG3409	Peptidoglycan-binding domain 1 protein
TFKS16_1081	COG0673	inositol 2-dehydrogenase activity
TFKS16_1083	COG2244	polysaccharide biosynthetic process
TFKS16_1084	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TFKS16_1085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TFKS16_1087	COG1028	Short-chain dehydrogenase reductase Sdr
TFKS16_1093	COG2089	acid synthase
TFKS16_1094	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TFKS16_1096	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TFKS16_1097	COG1083	cytidylyl-transferase
TFKS16_1099	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TFKS16_1104	COG0367	asparagine synthase
TFKS16_1108	COG3177	Filamentation induced by cAMP protein fic
TFKS16_1109	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TFKS16_1111	COG0438	transferase activity, transferring glycosyl groups
TFKS16_1113	COG0438	transferase activity, transferring glycosyl groups
TFKS16_1118	COG1185	polyribonucleotide nucleotidyltransferase activity
TFKS16_1119	COG2195	Cleaves the N-terminal amino acid of tripeptides
TFKS16_1121	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TFKS16_1122	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TFKS16_1122	COG0517	IMP dehydrogenase activity
TFKS16_1124	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TFKS16_1129	COG2814	Major facilitator Superfamily
TFKS16_1131	COG1629	transport
TFKS16_1131	COG4206	TonB-dependent receptor
TFKS16_1143	COG0731	radical SAM domain protein
TFKS16_1143	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TFKS16_1146	COG4948	Mandelate Racemase Muconate Lactonizing
TFKS16_1150	COG0116	Belongs to the methyltransferase superfamily
TFKS16_1151	COG1506	peptidase
TFKS16_1151	COG0823	Involved in the tonB-independent uptake of proteins
TFKS16_1152	COG0726	polysaccharide deacetylase
TFKS16_1155	COG0142	geranyltranstransferase activity
TFKS16_1156	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TFKS16_1156	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TFKS16_1157	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TFKS16_1158	COG2233	PERMEase
TFKS16_1160	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TFKS16_1161	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TFKS16_1165	COG1703	isobutyryl-CoA mutase activity
TFKS16_1166	COG1940	carbohydrate kinase activity
TFKS16_1168	COG0420	3'-5' exonuclease activity
TFKS16_1181	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TFKS16_1182	COG1482	cell wall glycoprotein biosynthetic process
TFKS16_1184	COG0561	phosphatase activity
TFKS16_1185	COG4206	TonB-dependent receptor
TFKS16_1185	COG1629	transport
TFKS16_1188	COG0528	UMP kinase activity
TFKS16_1189	COG0346	lactoylglutathione lyase activity
TFKS16_1190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TFKS16_1192	COG0511	ligase activity, forming carbon-carbon bonds
TFKS16_1193	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TFKS16_1194	COG1522	sequence-specific DNA binding
TFKS16_1197	COG0811	peptide transport
TFKS16_1199	COG0084	hydrolase, TatD family'
TFKS16_1203	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TFKS16_1204	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TFKS16_1206	COG1280	lysine exporter protein (LysE YggA)
TFKS16_1207	COG1022	Amp-dependent synthetase and ligase
TFKS16_1210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TFKS16_1211	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TFKS16_1212	COG0495	leucyl-tRNA aminoacylation
TFKS16_1214	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TFKS16_1215	COG2715	membrane protein required for spore maturation
TFKS16_1216	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TFKS16_1218	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TFKS16_1229	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TFKS16_1229	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TFKS16_1231	COG0802	atpase or kinase
TFKS16_1232	COG2204	response regulator
TFKS16_1235	COG1595	DNA-templated transcription, initiation
TFKS16_1241	COG0560	Phosphoserine phosphatase
TFKS16_1245	COG1373	ATPase (AAA superfamily
TFKS16_1246	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TFKS16_1250	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TFKS16_1251	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TFKS16_1257	COG0745	RESPONSE REGULATOR receiver
TFKS16_1279	COG0540	Belongs to the ATCase OTCase family
TFKS16_1280	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TFKS16_1284	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TFKS16_1285	COG1546	Belongs to the CinA family
TFKS16_1285	COG1058	Belongs to the CinA family
TFKS16_1286	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TFKS16_1287	COG0826	peptidase U32
TFKS16_1288	COG0646	methionine synthase
TFKS16_1288	COG1410	methionine synthase
TFKS16_1298	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TFKS16_1302	COG0473	3-isopropylmalate dehydrogenase activity
TFKS16_1303	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TFKS16_1304	COG0066	3-isopropylmalate dehydratase activity
TFKS16_1306	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TFKS16_1307	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TFKS16_1310	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TFKS16_1311	COG1482	cell wall glycoprotein biosynthetic process
TFKS16_1323	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TFKS16_1323	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TFKS16_1324	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TFKS16_1326	COG2194	sulfuric ester hydrolase activity
TFKS16_1327	COG0758	DNA mediated transformation
TFKS16_1336	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TFKS16_1339	COG0733	neurotransmitter:sodium symporter activity
TFKS16_1347	COG2996	Protein conserved in bacteria
TFKS16_1351	COG2986	histidine ammonia-lyase
TFKS16_1352	COG3404	Formiminotransferase-cyclodeaminase
TFKS16_1354	COG1228	amidohydrolase
TFKS16_1357	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TFKS16_1361	COG3119	arylsulfatase activity
TFKS16_1363	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TFKS16_1366	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TFKS16_1367	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TFKS16_1368	COG0739	heme binding
TFKS16_1374	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TFKS16_1375	COG3942	CHAP domain
TFKS16_1375	COG1388	LysM domain
TFKS16_1377	COG1475	DNA binding
TFKS16_1378	COG1192	Involved in chromosome partitioning
TFKS16_1380	COG0793	Belongs to the peptidase S41A family
TFKS16_1386	COG4206	TonB-dependent receptor
TFKS16_1389	COG4152	abc transporter atp-binding protein
TFKS16_1392	COG2986	histidine ammonia-lyase
TFKS16_1393	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TFKS16_1403	COG0366	Alpha amylase catalytic
TFKS16_1404	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TFKS16_1406	COG0482	sulfurtransferase activity
TFKS16_1409	COG4771	TonB-dependent receptor
TFKS16_1418	COG1943	Transposase
TFKS16_1423	COG0428	transporter
TFKS16_1425	COG2226	methyltransferase
TFKS16_1427	COG2226	methyltransferase
TFKS16_1429	COG2226	methyltransferase
TFKS16_1432	COG1132	(ABC) transporter
TFKS16_1434	COG1132	(ABC) transporter
TFKS16_1435	COG2066	Belongs to the glutaminase family
TFKS16_1439	COG0196	riboflavin kinase activity
TFKS16_1444	COG5492	domain, Protein
TFKS16_1445	COG0641	radical SAM
TFKS16_1447	COG1053	succinate dehydrogenase
TFKS16_1449	COG0018	arginyl-trna synthetase
TFKS16_1451	COG0525	valine-tRNA ligase activity
TFKS16_1460	COG1242	4 iron, 4 sulfur cluster binding
TFKS16_1462	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TFKS16_1468	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TFKS16_1468	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TFKS16_1472	COG0779	Required for maturation of 30S ribosomal subunits
TFKS16_1473	COG0195	Participates in both transcription termination and antitermination
TFKS16_1473	COG2251	uridine kinase activity
TFKS16_1474	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TFKS16_1476	COG0719	Fe-S assembly protein
TFKS16_1477	COG0396	ATPase activity
TFKS16_1478	COG0719	Fe-S assembly protein
TFKS16_1482	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TFKS16_1483	COG0436	Aminotransferase
TFKS16_1489	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TFKS16_1492	COG0393	Putative heavy-metal-binding
TFKS16_1493	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TFKS16_1494	COG2166	iron-sulfur cluster assembly
TFKS16_1496	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TFKS16_1497	COG0187	DNA topoisomerase II activity
TFKS16_1511	COG0268	Binds directly to 16S ribosomal RNA
TFKS16_1514	COG4206	TonB-dependent receptor
TFKS16_1514	COG1629	transport
TFKS16_1515	COG4206	TonB-dependent receptor
TFKS16_1515	COG1629	transport
TFKS16_1517	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TFKS16_1519	COG3118	belongs to the thioredoxin family
TFKS16_1525	COG0228	four-way junction DNA binding
TFKS16_1529	COG0514	ATP-dependent DNA helicase (RecQ)
TFKS16_1530	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TFKS16_1530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TFKS16_1533	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TFKS16_1535	COG0542	response to heat
TFKS16_1536	COG1253	flavin adenine dinucleotide binding
TFKS16_1537	COG1760	l-serine dehydratase
TFKS16_1538	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TFKS16_1539	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TFKS16_1540	COG0612	Peptidase, M16
TFKS16_1548	COG1940	carbohydrate kinase activity
TFKS16_1559	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TFKS16_1560	COG0674	pyruvate-flavodoxin oxidoreductase activity
TFKS16_1560	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TFKS16_1561	COG1013	pyruvate-flavodoxin oxidoreductase activity
TFKS16_1562	COG2177	Part of the ABC transporter FtsEX involved in
TFKS16_1564	COG1968	undecaprenyl-diphosphatase activity
TFKS16_1565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TFKS16_1566	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TFKS16_1567	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TFKS16_1578	COG1595	DNA-templated transcription, initiation
TFKS16_1580	COG0539	negative regulation of cytoplasmic translation
TFKS16_1581	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TFKS16_1582	COG1151	hydroxylamine reductase activity
TFKS16_1585	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TFKS16_1591	COG1271	oxidase subunit
TFKS16_1593	COG1595	DNA-templated transcription, initiation
TFKS16_1595	COG4206	TonB-dependent receptor
TFKS16_1595	COG1629	transport
TFKS16_1597	COG0673	inositol 2-dehydrogenase activity
TFKS16_1600	COG0612	Peptidase, M16
TFKS16_1601	COG0038	chloride channel
TFKS16_1602	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TFKS16_1606	COG0363	glucosamine-6-phosphate deaminase activity
TFKS16_1608	COG0426	domain, Protein
TFKS16_1609	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TFKS16_1610	COG0673	inositol 2-dehydrogenase activity
TFKS16_1612	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TFKS16_1613	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TFKS16_1614	COG0137	argininosuccinate synthase activity
TFKS16_1616	COG1438	arginine binding
TFKS16_1622	COG1032	radical SAM domain protein
TFKS16_1625	COG1131	(ABC) transporter
TFKS16_1628	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TFKS16_1629	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TFKS16_1630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TFKS16_1631	COG0742	ribosomal rna small subunit methyltransferase
TFKS16_1637	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TFKS16_1639	COG1011	Hydrolase
TFKS16_1642	COG1492	cobalamin metabolic process
TFKS16_1643	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TFKS16_1644	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TFKS16_1645	COG0251	oxidation-reduction process
TFKS16_1647	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TFKS16_1648	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TFKS16_1656	COG0336	Belongs to the RNA methyltransferase TrmD family
TFKS16_1658	COG0072	phenylalanine-tRNA ligase activity
TFKS16_1658	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TFKS16_1659	COG0217	transcriptional regulatory protein
TFKS16_1665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TFKS16_1666	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TFKS16_1667	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TFKS16_1668	COG0791	NLP P60 protein
TFKS16_1669	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TFKS16_1670	COG1408	metallophosphoesterase
TFKS16_1676	COG4139	cobalamin transport
TFKS16_1679	COG0632	four-way junction helicase activity
TFKS16_1682	COG1074	ATP-dependent DNA helicase activity
TFKS16_1683	COG0688	phosphatidylethanolamine metabolic process
TFKS16_1684	COG1183	phosphatidylcholine synthase activity
TFKS16_1686	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TFKS16_1696	COG0737	Belongs to the 5'-nucleotidase family
TFKS16_1709	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TFKS16_1710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TFKS16_1713	COG1381	Involved in DNA repair and RecF pathway recombination
TFKS16_1716	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TFKS16_1718	COG2843	Capsule synthesis protein
TFKS16_1719	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TFKS16_1720	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TFKS16_1721	COG4974	Belongs to the 'phage' integrase family
TFKS16_1725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TFKS16_1728	COG0250	Participates in transcription elongation, termination and antitermination
TFKS16_1729	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TFKS16_1730	COG0081	regulation of translation
TFKS16_1731	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TFKS16_1732	COG0222	ribosome binding
TFKS16_1733	COG0085	RNA polymerase activity
TFKS16_1734	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TFKS16_1735	COG0433	COG0433 Predicted ATPase
TFKS16_1739	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TFKS16_1740	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TFKS16_1741	COG4948	Mandelate Racemase Muconate Lactonizing
TFKS16_1745	COG4974	Belongs to the 'phage' integrase family
TFKS16_1767	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TFKS16_1777	COG1216	Glycosyl transferase, family 2
TFKS16_1781	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TFKS16_1792	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TFKS16_1795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TFKS16_1795	COG0047	phosphoribosylformylglycinamidine synthase activity
TFKS16_1802	COG4206	TonB-dependent receptor
TFKS16_1802	COG1629	transport
TFKS16_1805	COG4221	oxidoreductase activity
TFKS16_1808	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TFKS16_1810	COG1368	sulfuric ester hydrolase activity
TFKS16_1811	COG1047	Peptidyl-prolyl cis-trans
TFKS16_1812	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TFKS16_1813	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_1816	COG0750	zinc metalloprotease
TFKS16_1818	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TFKS16_1819	COG4942	peptidase
TFKS16_1820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TFKS16_1823	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TFKS16_1824	COG2183	response to ionizing radiation
TFKS16_1829	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TFKS16_1832	COG0488	(ABC) transporter
TFKS16_1833	COG0516	GMP reductase activity
TFKS16_1834	COG1918	ferrous iron import across plasma membrane
TFKS16_1834	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TFKS16_1836	COG3275	phosphorelay sensor kinase activity
TFKS16_1837	COG3279	Response regulator of the LytR AlgR family
TFKS16_1850	COG0148	phosphopyruvate hydratase activity
TFKS16_1852	COG0716	FMN binding
TFKS16_1857	COG4771	TonB-dependent receptor
TFKS16_1858	COG4771	TonB-dependent receptor
TFKS16_1862	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TFKS16_1863	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TFKS16_1867	COG3876	Protein conserved in bacteria
TFKS16_1868	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TFKS16_1869	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TFKS16_1870	COG0052	Belongs to the universal ribosomal protein uS2 family
TFKS16_1871	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TFKS16_1881	COG1629	transport
TFKS16_1881	COG4206	TonB-dependent receptor
TFKS16_1889	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TFKS16_1889	COG4651	solute:proton antiporter activity
TFKS16_1891	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TFKS16_1896	COG1418	mRNA catabolic process
TFKS16_1897	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TFKS16_1898	COG0488	(ABC) transporter
TFKS16_1901	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TFKS16_1908	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TFKS16_1911	COG3876	Protein conserved in bacteria
TFKS16_1913	COG2871	sodium ion transport
TFKS16_1914	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TFKS16_1915	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TFKS16_1917	COG1805	sodium ion transport
TFKS16_1918	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TFKS16_1920	COG0739	heme binding
TFKS16_1921	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TFKS16_1922	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TFKS16_1923	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TFKS16_1924	COG0563	adenylate kinase activity
TFKS16_1926	COG3845	ABC transporter
TFKS16_1928	COG0346	lactoylglutathione lyase activity
TFKS16_1931	COG0463	Glycosyl transferase, family 2
TFKS16_1933	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TFKS16_1934	COG4452	Inner membrane protein CreD
TFKS16_1942	COG0564	pseudouridine synthase activity
TFKS16_1944	COG1028	Short-chain dehydrogenase reductase Sdr
TFKS16_1945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TFKS16_1946	COG1309	transcriptional regulator
TFKS16_1951	COG1472	Belongs to the glycosyl hydrolase 3 family
TFKS16_1952	COG2885	chlorophyll binding
TFKS16_1956	COG0542	response to heat
TFKS16_1967	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TFKS16_1969	COG2271	Major facilitator Superfamily
TFKS16_1970	COG4206	TonB-dependent receptor
TFKS16_1970	COG1629	transport
TFKS16_1973	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TFKS16_1979	COG4822	anaerobic cobalamin biosynthetic process
TFKS16_1982	COG4771	TonB-dependent receptor
TFKS16_1983	COG1477	protein flavinylation
TFKS16_1988	COG1480	7TM receptor with intracellular HD hydrolase
TFKS16_2016	COG4383	Mu-like prophage protein gp29
TFKS16_2040	COG0641	radical SAM
TFKS16_2054	COG1072	(Pantothenic acid kinase))
TFKS16_2058	COG1131	(ABC) transporter
TFKS16_2059	COG1131	(ABC) transporter
TFKS16_2060	COG0842	Transport permease protein
TFKS16_2065	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TFKS16_2066	COG4206	TonB-dependent receptor
TFKS16_2066	COG1629	transport
TFKS16_2067	COG1082	Xylose isomerase domain protein TIM barrel
TFKS16_2069	COG0343	queuine tRNA-ribosyltransferase activity
TFKS16_2071	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TFKS16_2073	COG1773	rubredoxin
TFKS16_2074	COG0583	DNA-binding transcription factor activity
TFKS16_2076	COG0668	transmembrane transport
TFKS16_2077	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TFKS16_2079	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
TFKS16_2080	COG1629	transport
TFKS16_2080	COG4206	TonB-dependent receptor
TFKS16_2082	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TFKS16_2084	COG3119	arylsulfatase activity
TFKS16_2087	COG1028	Short-chain dehydrogenase reductase Sdr
TFKS16_2089	COG2271	Major facilitator Superfamily
TFKS16_2093	COG0577	efflux transmembrane transporter activity
TFKS16_2111	COG1570	exodeoxyribonuclease VII activity
TFKS16_2114	COG2502	aspartate--ammonia ligase
TFKS16_2116	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TFKS16_2116	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TFKS16_2117	COG1752	Esterase of the alpha-beta hydrolase superfamily
TFKS16_2119	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TFKS16_2131	COG3177	Filamentation induced by cAMP protein fic
TFKS16_2134	COG1353	crispr-associated protein
TFKS16_2136	COG1337	RAMP superfamily
TFKS16_2141	COG1518	maintenance of DNA repeat elements
TFKS16_2142	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TFKS16_2147	COG1528	Iron-storage protein
TFKS16_2148	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TFKS16_2152	COG0776	regulation of translation
TFKS16_2153	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TFKS16_2155	COG1640	4-alpha-glucanotransferase
TFKS16_2159	COG4589	Belongs to the CDS family
TFKS16_2160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TFKS16_2161	COG0799	negative regulation of ribosome biogenesis
TFKS16_2166	COG4206	TonB-dependent receptor
TFKS16_2166	COG1629	transport
TFKS16_2172	COG0285	dihydrofolate synthase activity
TFKS16_2173	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TFKS16_2175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TFKS16_2188	COG3177	Filamentation induced by cAMP protein fic
TFKS16_2192	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TFKS16_2194	COG4974	Belongs to the 'phage' integrase family
TFKS16_2200	COG0497	DNA recombination
TFKS16_2201	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TFKS16_2202	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TFKS16_2203	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TFKS16_2204	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TFKS16_2205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TFKS16_2207	COG2195	Cleaves the N-terminal amino acid of tripeptides
TFKS16_2210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TFKS16_2211	COG1979	alcohol dehydrogenase
TFKS16_2216	COG3250	beta-galactosidase activity
TFKS16_2217	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TFKS16_2220	COG0470	DNA polymerase III
TFKS16_2221	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TFKS16_2223	COG0534	Mate efflux family protein
TFKS16_2225	COG1629	transport
TFKS16_2225	COG4206	TonB-dependent receptor
TFKS16_2233	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TFKS16_2234	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TFKS16_2235	COG1748	Saccharopine dehydrogenase
TFKS16_2238	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TFKS16_2239	COG1215	transferase activity, transferring glycosyl groups
TFKS16_2246	COG3209	COG3209 Rhs family protein
TFKS16_2247	COG3209	COG3209 Rhs family protein
TFKS16_2249	COG3209	COG3209 Rhs family protein
TFKS16_2250	COG3209	COG3209 Rhs family protein
TFKS16_2271	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TFKS16_2272	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TFKS16_2274	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TFKS16_2278	COG0358	DNA primase activity
TFKS16_2289	COG3344	reverse transcriptase
TFKS16_2304	COG1944	ATP diphosphatase activity
TFKS16_2306	COG1944	ATP diphosphatase activity
TFKS16_2307	COG0641	radical SAM
TFKS16_2308	COG0156	8-amino-7-oxononanoate synthase activity
TFKS16_2314	COG3344	reverse transcriptase
TFKS16_2322	COG0582	viral genome integration into host DNA
TFKS16_2327	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TFKS16_2330	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TFKS16_2335	COG4206	TonB-dependent receptor
TFKS16_2335	COG1629	transport
TFKS16_2341	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TFKS16_2344	COG0739	heme binding
TFKS16_2347	COG0149	triose-phosphate isomerase activity
TFKS16_2349	COG0302	gtp cyclohydrolase
TFKS16_2350	COG0009	L-threonylcarbamoyladenylate synthase
TFKS16_2353	COG4690	dipeptidase activity
TFKS16_2358	COG0545	Peptidyl-prolyl cis-trans isomerase
TFKS16_2359	COG0545	Peptidyl-prolyl cis-trans isomerase
TFKS16_2368	COG1629	transport
TFKS16_2368	COG4206	TonB-dependent receptor
TFKS16_2372	COG0823	Involved in the tonB-independent uptake of proteins
TFKS16_2376	COG0463	Glycosyl transferase, family 2
TFKS16_2377	COG1649	PFAM Uncharacterised BCR, COG1649
TFKS16_2378	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TFKS16_2381	COG0860	N-Acetylmuramoyl-L-alanine amidase
TFKS16_2381	COG1388	LysM domain
TFKS16_2383	COG1388	LysM domain
TFKS16_2383	COG0741	lytic transglycosylase activity
TFKS16_2384	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TFKS16_2386	COG1739	Uncharacterized protein family UPF0029
TFKS16_2389	COG0006	proline dipeptidase activity
TFKS16_2390	COG1785	Belongs to the alkaline phosphatase family
TFKS16_2393	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_2393	COG5549	protein import
TFKS16_2398	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_2398	COG5549	protein import
TFKS16_2401	COG5549	protein import
TFKS16_2401	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_2402	COG5549	protein import
TFKS16_2402	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_2405	COG5549	protein import
TFKS16_2405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_2407	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_2407	COG5549	protein import
TFKS16_2408	COG5549	protein import
TFKS16_2408	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_2410	COG5549	protein import
TFKS16_2410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_2412	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_2412	COG5549	protein import
TFKS16_2413	COG5549	protein import
TFKS16_2413	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFKS16_2421	COG1649	PFAM Uncharacterised BCR, COG1649
TFKS16_2423	COG0492	ferredoxin-NADP+ reductase activity
TFKS16_2425	COG1674	ftsk spoiiie
TFKS16_2426	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TFKS16_2427	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TFKS16_2429	COG0037	tRNA processing
TFKS16_2432	COG0450	alkyl hydroperoxide reductase
TFKS16_2434	COG2197	response regulator
TFKS16_2436	COG2985	domain, Protein
TFKS16_2436	COG0569	domain protein
TFKS16_2441	COG1620	l-lactate permease
TFKS16_2442	COG1556	Lactate utilization protein
TFKS16_2443	COG1139	Iron-sulfur cluster binding protein
TFKS16_2452	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TFKS16_2453	COG0321	lipoyl(octanoyl) transferase activity
TFKS16_2455	COG1774	PSP1 C-terminal conserved region
TFKS16_2456	COG0156	8-amino-7-oxononanoate synthase activity
TFKS16_2457	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TFKS16_2459	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TFKS16_2460	COG0402	S-adenosylhomocysteine deaminase activity
TFKS16_2471	COG4206	TonB-dependent receptor
TFKS16_2471	COG1629	transport
TFKS16_2472	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TFKS16_2474	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TFKS16_2475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TFKS16_2475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TFKS16_2477	COG0488	(ABC) transporter
TFKS16_2479	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TFKS16_2480	COG0706	membrane insertase activity
TFKS16_2481	COG0504	CTP synthase activity
TFKS16_2482	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TFKS16_2486	COG2878	Part of a membrane complex involved in electron transport
TFKS16_2486	COG1245	4Fe-4S binding domain
TFKS16_2487	COG4656	Part of a membrane complex involved in electron transport
TFKS16_2488	COG4658	electron transport chain
TFKS16_2489	COG4659	FMN binding
TFKS16_2490	COG4660	Part of a membrane complex involved in electron transport
TFKS16_2491	COG4657	Part of a membrane complex involved in electron transport
TFKS16_2499	COG2252	PERMEase
TFKS16_2503	COG3119	arylsulfatase activity
TFKS16_2505	COG2096	Adenosyltransferase
TFKS16_2507	COG2242	protein methyltransferase activity
TFKS16_2509	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TFKS16_2517	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TFKS16_2521	COG3104	oligopeptide transport
TFKS16_2526	COG4206	TonB-dependent receptor
TFKS16_2526	COG1629	transport
TFKS16_2532	COG2115	Belongs to the xylose isomerase family
TFKS16_2533	COG0477	Major facilitator Superfamily
TFKS16_2533	COG2814	Major facilitator Superfamily
TFKS16_2536	COG1629	transport
TFKS16_2536	COG4206	TonB-dependent receptor
TFKS16_2550	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TFKS16_2551	COG1032	radical SAM domain protein
TFKS16_2552	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TFKS16_2553	COG0513	Belongs to the DEAD box helicase family
TFKS16_2565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TFKS16_2567	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TFKS16_2568	COG1663	tetraacyldisaccharide 4'-kinase activity
TFKS16_2569	COG0616	signal peptide processing
TFKS16_2572	COG0534	Mate efflux family protein
TFKS16_2575	COG1505	serine-type exopeptidase activity
TFKS16_2577	COG5002	protein histidine kinase activity
TFKS16_2589	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TFKS16_2589	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TFKS16_2590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TFKS16_2591	COG0357	Ribosomal RNA small subunit methyltransferase G
TFKS16_2594	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TFKS16_2598	COG0671	phosphoesterase, PA-phosphatase related
TFKS16_2602	COG2304	oxidoreductase activity
TFKS16_2603	COG2304	oxidoreductase activity
TFKS16_2606	COG0714	Associated with various cellular activities
TFKS16_2608	COG0776	regulation of translation
TFKS16_2609	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TFKS16_2610	COG0552	protein localization to endoplasmic reticulum
TFKS16_2621	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TFKS16_2625	COG1530	ribonuclease E activity
TFKS16_2626	COG0776	regulation of translation
TFKS16_2629	COG0629	single-stranded DNA binding
TFKS16_2630	COG4535	Mg2 and Co2 transporter CorC
TFKS16_2638	COG4206	TonB-dependent receptor
TFKS16_2638	COG1629	transport
TFKS16_2642	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TFKS16_2643	COG0671	phosphoesterase, PA-phosphatase related
TFKS16_2652	COG0673	inositol 2-dehydrogenase activity
TFKS16_2653	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TFKS16_2654	COG2195	Cleaves the N-terminal amino acid of tripeptides
TFKS16_2656	COG0463	Glycosyl transferase, family 2
TFKS16_2658	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TFKS16_2660	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TFKS16_2662	COG1611	Belongs to the LOG family
TFKS16_2663	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TFKS16_2667	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TFKS16_2669	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TFKS16_2670	COG2226	methyltransferase
TFKS16_2671	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TFKS16_2675	COG0006	proline dipeptidase activity
TFKS16_2687	COG3250	beta-galactosidase activity
TFKS16_2689	COG0481	GTPase activity
TFKS16_2690	COG1629	transport
TFKS16_2690	COG4206	TonB-dependent receptor
TFKS16_2693	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TFKS16_2694	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TFKS16_2695	COG0574	Belongs to the PEP-utilizing enzyme family
TFKS16_2695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TFKS16_2700	COG0631	protein serine/threonine phosphatase activity
TFKS16_2705	COG1629	transport
TFKS16_2705	COG4206	TonB-dependent receptor
TFKS16_2709	COG0156	8-amino-7-oxononanoate synthase activity
TFKS16_2715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TFKS16_2719	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TFKS16_2726	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TFKS16_2727	COG0489	protein tyrosine kinase activity
TFKS16_2729	COG0793	Belongs to the peptidase S41A family
TFKS16_2730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TFKS16_2737	COG2194	sulfuric ester hydrolase activity
TFKS16_2746	COG0300	oxidoreductase activity
TFKS16_2749	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TFKS16_2751	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TFKS16_2752	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TFKS16_2757	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
TFKS16_2758	COG0653	protein targeting
TFKS16_2761	COG0242	peptide deformylase activity
TFKS16_2762	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TFKS16_2763	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TFKS16_2767	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TFKS16_2768	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TFKS16_2769	COG4591	ABC-type transport system involved in lipoprotein release permease component
TFKS16_2770	COG0436	Aminotransferase
TFKS16_2772	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TFKS16_2774	COG1678	Uncharacterized ACR, COG1678
TFKS16_2775	COG2873	o-acetylhomoserine
TFKS16_2776	COG1668	transmembrane transport
TFKS16_2777	COG4152	abc transporter atp-binding protein
TFKS16_2778	COG0358	DNA primase activity
TFKS16_2780	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TFKS16_2785	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TFKS16_2788	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TFKS16_2791	COG1506	peptidase
TFKS16_2791	COG0823	Involved in the tonB-independent uptake of proteins
TFKS16_2792	COG0424	maF-like protein
TFKS16_2793	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TFKS16_2798	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TFKS16_2799	COG0193	aminoacyl-tRNA hydrolase activity
TFKS16_2800	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TFKS16_2809	COG0681	Belongs to the peptidase S26 family
TFKS16_2810	COG1132	(ABC) transporter
TFKS16_2813	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TFKS16_2816	COG1575	Belongs to the MenA family. Type 1 subfamily
TFKS16_2817	COG4206	TonB-dependent receptor
TFKS16_2817	COG1629	transport
TFKS16_2823	COG0848	biopolymer transport protein
TFKS16_2824	COG0811	peptide transport
TFKS16_2825	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TFKS16_2826	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TFKS16_2831	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TFKS16_2832	COG2268	Band 7 protein
TFKS16_2837	COG0490	domain, Protein
TFKS16_2837	COG2985	domain, Protein
TFKS16_2853	COG1295	ribonuclease BN
TFKS16_2855	COG0527	aspartate kinase activity
TFKS16_2855	COG0460	homoserine dehydrogenase
TFKS16_2856	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TFKS16_2858	COG0363	glucosamine-6-phosphate deaminase activity
TFKS16_2859	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TFKS16_2867	COG2832	Protein of unknown function (DUF454)
TFKS16_2868	COG2234	aminopeptidase activity
TFKS16_2870	COG0778	Nitroreductase
TFKS16_2871	COG0318	PFAM AMP-dependent synthetase and ligase
TFKS16_2879	COG1309	transcriptional regulator
TFKS16_2890	COG1373	ATPase (AAA superfamily
TFKS16_2894	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TFKS16_2894	COG0731	radical SAM domain protein
TFKS16_2927	COG4974	Belongs to the 'phage' integrase family
TFKS16_2929	COG4974	Belongs to the 'phage' integrase family
TFKS16_2937	COG3645	SOS response
TFKS16_2940	COG2207	Transcriptional regulator
TFKS16_2940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TFKS16_2947	COG1373	ATPase (AAA superfamily
TFKS16_2955	COG1196	nuclear chromosome segregation
TFKS16_2964	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TFKS16_2966	COG0564	pseudouridine synthase activity
TFKS16_2967	COG1181	Belongs to the D-alanine--D-alanine ligase family
TFKS16_2969	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TFKS16_2970	COG0179	Fumarylacetoacetate (FAA) hydrolase
TFKS16_2973	COG0793	Belongs to the peptidase S41A family
TFKS16_2973	COG4946	Tricorn protease homolog
TFKS16_2974	COG3250	beta-galactosidase activity
TFKS16_2976	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TFKS16_2983	COG1028	Short-chain dehydrogenase reductase Sdr
TFKS16_2987	COG3022	response to hydroperoxide
TFKS16_2990	COG1629	transport
TFKS16_2990	COG4206	TonB-dependent receptor
TFKS16_2998	COG0254	rRNA binding
TFKS16_2999	COG0191	fructose-bisphosphate aldolase activity
TFKS16_3000	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TFKS16_3005	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TFKS16_3012	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TFKS16_3015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TFKS16_3016	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TFKS16_3017	COG0805	protein transport
TFKS16_3018	COG0805	protein transport
TFKS16_3019	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TFKS16_3020	COG0305	Participates in initiation and elongation during chromosome replication
TFKS16_3022	COG0488	(ABC) transporter
TFKS16_3024	COG0138	bifunctional purine biosynthesis protein purh
TFKS16_3029	COG0772	Belongs to the SEDS family
TFKS16_3030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TFKS16_3031	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TFKS16_3032	COG0166	Belongs to the GPI family
TFKS16_3034	COG0360	Binds together with S18 to 16S ribosomal RNA
TFKS16_3035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TFKS16_3036	COG0359	binds to the 23S rRNA
TFKS16_3037	COG0860	N-Acetylmuramoyl-L-alanine amidase