locus-tag	class	description
HB776_00005	COG0583	DNA-binding transcription factor activity
HB776_00010	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_00015	COG3959	Transketolase, thiamine diphosphate binding domain
HB776_00020	COG3958	Transketolase
HB776_00025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB776_00075	COG0523	cobalamin synthesis protein
HB776_00080	COG0523	cobalamin synthesis protein
HB776_00110	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HB776_00270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB776_00305	COG4608	Belongs to the ABC transporter superfamily
HB776_00310	COG0444	Belongs to the ABC transporter superfamily
HB776_00315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_00320	COG0601	transmembrane transport
HB776_00330	COG0523	cobalamin synthesis protein
HB776_00360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_00375	COG1045	serine acetyltransferase
HB776_00380	COG1464	Belongs to the NlpA lipoprotein family
HB776_00395	COG1116	anion transmembrane transporter activity
HB776_00400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_00405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_00420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_00425	COG0747	negative chemotaxis
HB776_00430	COG0601	transmembrane transport
HB776_00435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_00455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_00460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_00470	COG1116	anion transmembrane transporter activity
HB776_00470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_00495	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_00525	COG0438	transferase activity, transferring glycosyl groups
HB776_00540	COG3693	PFAM glycoside hydrolase, family 10
HB776_00570	COG0489	protein tyrosine kinase activity
HB776_00570	COG3206	protein involved in exopolysaccharide biosynthesis
HB776_00600	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HB776_00625	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HB776_00630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB776_00645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_00650	COG4172	Belongs to the ABC transporter superfamily
HB776_00655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_00660	COG0601	transmembrane transport
HB776_00665	COG0747	negative chemotaxis
HB776_00670	COG0753	catalase activity
HB776_00690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB776_00715	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_00765	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_00770	COG0028	Belongs to the TPP enzyme family
HB776_00805	COG0747	negative chemotaxis
HB776_00810	COG0601	transmembrane transport
HB776_00815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_00835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_00840	COG0601	transmembrane transport
HB776_00845	COG0747	negative chemotaxis
HB776_00850	COG2072	flavoprotein involved in K transport
HB776_00855	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_00860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB776_00865	COG1802	Transcriptional regulator
HB776_00895	COG0583	DNA-binding transcription factor activity
HB776_00915	COG1012	belongs to the aldehyde dehydrogenase family
HB776_00925	COG0667	Aldo Keto reductase
HB776_00930	COG1012	belongs to the aldehyde dehydrogenase family
HB776_00950	COG1802	Transcriptional regulator
HB776_00955	COG0444	Belongs to the ABC transporter superfamily
HB776_00960	COG4608	Belongs to the ABC transporter superfamily
HB776_00980	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_01015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB776_01025	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HB776_01085	COG2201	protein-glutamate methylesterase activity
HB776_01095	COG0754	glutathionylspermidine amidase activity
HB776_01105	COG3766	membrane
HB776_01145	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HB776_01200	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HB776_01285	COG0494	nUDIX hydrolase
HB776_01295	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HB776_01300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HB776_01335	COG3547	Transposase (IS116 IS110 IS902 family)
HB776_01375	COG0746	molybdenum cofactor guanylyltransferase activity
HB776_01380	COG0425	Belongs to the sulfur carrier protein TusA family
HB776_01385	COG2223	nitrite transmembrane transporter activity
HB776_01405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB776_01425	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HB776_01450	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HB776_01460	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HB776_01465	COG0366	Alpha amylase catalytic
HB776_01470	COG0366	Alpha amylase catalytic
HB776_01475	COG1640	4-alpha-glucanotransferase
HB776_01490	COG3265	gluconokinase activity
HB776_01495	COG0363	glucosamine-6-phosphate deaminase activity
HB776_01500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HB776_01505	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HB776_01510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HB776_01535	COG0535	radical SAM domain protein
HB776_01545	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HB776_01550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HB776_01575	COG0154	amidase activity
HB776_01580	COG0386	Belongs to the glutathione peroxidase family
HB776_01595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_01600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_01605	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB776_01610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HB776_01625	COG2267	carboxylic ester hydrolase activity
HB776_01650	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_01655	COG1024	Enoyl-CoA hydratase
HB776_01675	COG0410	ABC transporter
HB776_01680	COG1137	ATPase activity
HB776_01685	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_01690	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_01720	COG2207	Transcriptional regulator
HB776_01770	COG1024	Enoyl-CoA hydratase
HB776_01790	COG2814	Major facilitator Superfamily
HB776_01795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB776_01810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB776_01820	COG2203	Gaf domain
HB776_01820	COG3706	GGDEF domain
HB776_01820	COG4251	negative regulation of phosphorylation
HB776_01820	COG5001	Diguanylate cyclase
HB776_01835	COG2897	thiosulfate sulfurtransferase activity
HB776_01845	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_01850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB776_01865	COG4106	trans-aconitate 2-methyltransferase activity
HB776_01925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB776_01950	COG2204	response regulator
HB776_01955	COG2391	methyltransferase activity
HB776_01965	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HB776_01975	COG2022	thiamine diphosphate biosynthetic process
HB776_02030	COG1388	LysM domain
HB776_02030	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_02035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_02045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_02055	COG1309	transcriptional regulator
HB776_02070	COG5265	(ABC) transporter
HB776_02090	COG3795	YCII-related domain
HB776_02095	COG4941	Belongs to the sigma-70 factor family
HB776_02100	COG3023	N-Acetylmuramoyl-L-alanine amidase
HB776_02120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HB776_02130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HB776_02135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HB776_02150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HB776_02160	COG0583	DNA-binding transcription factor activity
HB776_02165	COG2814	Major facilitator Superfamily
HB776_02170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HB776_02175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HB776_02185	COG1181	Belongs to the D-alanine--D-alanine ligase family
HB776_02190	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HB776_02195	COG0849	cell division
HB776_02200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HB776_02210	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB776_02225	COG2814	Major facilitator Superfamily
HB776_02230	COG0006	proline dipeptidase activity
HB776_02230	COG0006	proline dipeptidase activity
HB776_02240	COG2264	protein methyltransferase activity
HB776_02245	COG1233	COG1233 Phytoene dehydrogenase and related
HB776_02265	COG0842	Transport permease protein
HB776_02270	COG1131	(ABC) transporter
HB776_02280	COG0210	DNA helicase
HB776_02285	COG5487	UPF0391 membrane protein
HB776_02295	COG0277	FAD linked oxidase domain protein
HB776_02300	COG2271	Major facilitator Superfamily
HB776_02320	COG0114	fumarate hydratase activity
HB776_02360	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HB776_02390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HB776_02455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB776_02455	COG2010	Cytochrome c
HB776_02470	COG1294	oxidase, subunit
HB776_02500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_02520	COG4191	Histidine kinase
HB776_02545	COG4566	intracellular signal transduction
HB776_02550	COG0745	RESPONSE REGULATOR receiver
HB776_02565	COG5002	protein histidine kinase activity
HB776_02570	COG1309	transcriptional regulator
HB776_02575	COG1566	PFAM secretion protein HlyD family protein
HB776_02585	COG0656	L-ascorbic acid biosynthetic process
HB776_02590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB776_02595	COG4977	sequence-specific DNA binding
HB776_02625	COG1942	4-Oxalocrotonate Tautomerase
HB776_02630	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_02635	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB776_02640	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HB776_02655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB776_02655	COG1017	nitric oxide dioxygenase activity
HB776_02660	COG2267	carboxylic ester hydrolase activity
HB776_02675	COG1024	Enoyl-CoA hydratase
HB776_02675	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB776_02695	COG0596	Alpha beta hydrolase
HB776_02705	COG1764	response to oxidative stress
HB776_02735	COG0330	HflC and HflK could
HB776_02740	COG0330	HflC and HflK could
HB776_02755	COG0560	Phosphoserine phosphatase
HB776_02760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HB776_02765	COG3549	Plasmid maintenance system killer
HB776_02770	COG3093	addiction module antidote protein HigA
HB776_02775	COG0028	Belongs to the TPP enzyme family
HB776_02780	COG0440	acetolactate synthase activity
HB776_02795	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HB776_02810	COG0300	oxidoreductase activity
HB776_02815	COG2186	Transcriptional regulator
HB776_02835	COG1174	glycine betaine transport
HB776_02840	COG0517	IMP dehydrogenase activity
HB776_02840	COG1125	glycine betaine transport
HB776_02850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_02855	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HB776_02870	COG2326	polyphosphate kinase activity
HB776_02875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB776_02880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HB776_02950	COG1024	Enoyl-CoA hydratase
HB776_02960	COG0463	Glycosyl transferase, family 2
HB776_02970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB776_02975	COG1408	metallophosphoesterase
HB776_02985	COG0247	lactate metabolic process
HB776_02985	COG0277	FAD linked oxidase domain protein
HB776_02990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HB776_02995	COG1024	Enoyl-CoA hydratase
HB776_03000	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_03020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_03045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HB776_03045	COG2755	lipolytic protein G-D-S-L family
HB776_03055	COG1696	Membrane protein involved in D-alanine export
HB776_03100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB776_03125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB776_03130	COG1216	Glycosyl transferase, family 2
HB776_03145	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HB776_03145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HB776_03150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HB776_03155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB776_03160	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HB776_03170	COG3959	Transketolase, thiamine diphosphate binding domain
HB776_03175	COG3958	Transketolase
HB776_03180	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB776_03200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HB776_03205	COG2942	2-epimerase
HB776_03240	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_03245	COG1022	Amp-dependent synthetase and ligase
HB776_03265	COG0411	ABC transporter
HB776_03285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_03340	COG0410	ABC transporter
HB776_03345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HB776_03365	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HB776_03380	COG0270	DNA (cytosine-5-)-methyltransferase activity
HB776_03400	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HB776_03410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HB776_03415	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HB776_03435	COG1132	(ABC) transporter
HB776_03440	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HB776_03445	COG2207	Transcriptional regulator
HB776_03465	COG0859	PFAM glycosyl transferase family 9
HB776_03475	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HB776_03475	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HB776_03480	COG1086	Polysaccharide biosynthesis protein
HB776_03495	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HB776_03495	COG0662	Cupin 2, conserved barrel domain protein
HB776_03500	COG0673	inositol 2-dehydrogenase activity
HB776_03515	COG0728	peptidoglycan biosynthetic process
HB776_03585	COG1088	dTDP-glucose 4,6-dehydratase activity
HB776_03595	COG1045	serine acetyltransferase
HB776_03660	COG3944	biosynthesis protein
HB776_03695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HB776_03735	COG1450	Type ii and iii secretion system protein
HB776_03750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HB776_03755	COG1459	type II secretion system
HB776_03795	COG2165	general secretion pathway protein
HB776_03835	COG3909	cytochrome
HB776_03855	COG2010	Cytochrome c
HB776_03925	COG3386	PFAM SMP-30 Gluconolaconase
HB776_03930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB776_03935	COG0129	dihydroxy-acid dehydratase activity
HB776_03945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB776_03960	COG1309	transcriptional regulator
HB776_03965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_03975	COG1116	anion transmembrane transporter activity
HB776_03985	COG0673	inositol 2-dehydrogenase activity
HB776_04005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_04010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB776_04020	COG1573	uracil-dna glycosylase
HB776_04040	COG0587	DNA-directed DNA polymerase activity
HB776_04065	COG4251	negative regulation of phosphorylation
HB776_04075	COG0427	acetyl-CoA hydrolase
HB776_04100	COG0492	ferredoxin-NADP+ reductase activity
HB776_04105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB776_04155	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HB776_04160	COG1703	isobutyryl-CoA mutase activity
HB776_04200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HB776_04210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HB776_04225	COG0433	COG0433 Predicted ATPase
HB776_04245	COG0235	Class ii aldolase
HB776_04250	COG4977	sequence-specific DNA binding
HB776_04295	COG4957	zinc ion binding
HB776_04305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HB776_04310	COG2166	iron-sulfur cluster assembly
HB776_04320	COG2205	protein histidine kinase activity
HB776_04380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HB776_04385	COG2983	Belongs to the UPF0260 family
HB776_04390	COG2814	Major facilitator Superfamily
HB776_04430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HB776_04530	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_04600	COG0625	glutathione transferase activity
HB776_04605	COG4235	cytochrome complex assembly
HB776_04610	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HB776_04615	COG1138	Cytochrome C-type biogenesis protein
HB776_04620	COG3088	subunit of a heme lyase
HB776_04625	COG1802	Transcriptional regulator
HB776_04650	COG0745	RESPONSE REGULATOR receiver
HB776_04680	COG2205	protein histidine kinase activity
HB776_04685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HB776_04705	COG2202	Pas domain
HB776_04705	COG2205	protein histidine kinase activity
HB776_04710	COG0604	alcohol dehydrogenase
HB776_04710	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_04710	COG3321	synthase
HB776_04725	COG2080	2 iron, 2 sulfur cluster binding
HB776_04730	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HB776_04735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB776_04775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_04795	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HB776_04810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_04825	COG1024	Enoyl-CoA hydratase
HB776_04830	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_04880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_04885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB776_04910	COG2205	protein histidine kinase activity
HB776_04910	COG2202	Pas domain
HB776_04915	COG2084	Dehydrogenase
HB776_04920	COG0489	protein tyrosine kinase activity
HB776_04925	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HB776_04930	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HB776_04955	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HB776_04965	COG0546	phosphoglycolate phosphatase activity
HB776_04970	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HB776_04990	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HB776_04995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HB776_05020	COG0215	cysteine-tRNA ligase activity
HB776_05040	COG5265	(ABC) transporter
HB776_05045	COG0688	phosphatidylethanolamine metabolic process
HB776_05050	COG1183	phosphatidylcholine synthase activity
HB776_05065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HB776_05075	COG3158	transport of potassium into the cell
HB776_05080	COG3158	transport of potassium into the cell
HB776_05090	COG0436	Aminotransferase
HB776_05095	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HB776_05100	COG1560	Kdo2-lipid A biosynthetic process
HB776_05105	COG0604	alcohol dehydrogenase
HB776_05105	COG3321	synthase
HB776_05110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB776_05120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HB776_05125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB776_05140	COG1285	pathogenesis
HB776_05155	COG0583	DNA-binding transcription factor activity
HB776_05170	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HB776_05190	COG1953	Uracil, thiamine, allantoin
HB776_05215	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_05220	COG0367	asparagine synthase
HB776_05225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HB776_05230	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HB776_05235	COG0840	transmembrane signaling receptor activity
HB776_05240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HB776_05255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB776_05260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_05270	COG4774	siderophore transport
HB776_05275	COG3128	pkhd-type hydroxylase
HB776_05285	COG0848	biopolymer transport protein
HB776_05295	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_05300	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_05305	COG0129	dihydroxy-acid dehydratase activity
HB776_05310	COG3842	ATPase activity
HB776_05330	COG0395	ABC-type sugar transport system, permease component
HB776_05335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB776_05340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB776_05345	COG0800	Aldolase
HB776_05350	COG0183	Belongs to the thiolase family
HB776_05355	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_05360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_05370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB776_05380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB776_05380	COG0045	succinate-CoA ligase (ADP-forming) activity
HB776_05380	COG1042	CoA-binding domain protein
HB776_05385	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB776_05400	COG0415	Belongs to the DNA photolyase family
HB776_05410	COG0450	alkyl hydroperoxide reductase
HB776_05440	COG4770	biotin carboxylase activity
HB776_05445	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HB776_05450	COG1254	Belongs to the acylphosphatase family
HB776_05455	COG0321	lipoyl(octanoyl) transferase activity
HB776_05580	COG3293	Transposase
HB776_05665	COG2239	Acts as a magnesium transporter
HB776_05690	COG0656	L-ascorbic acid biosynthetic process
HB776_05740	COG2030	dehydratase
HB776_05745	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_05765	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_05995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB776_06025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB776_06030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB776_06035	COG2271	Major facilitator Superfamily
HB776_06040	COG0183	Belongs to the thiolase family
HB776_06045	COG1024	Enoyl-CoA hydratase
HB776_06045	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB776_06060	COG1960	acyl-CoA dehydrogenase activity
HB776_06075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB776_06085	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_06090	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB776_06090	COG0493	'glutamate synthase
HB776_06100	COG0488	(ABC) transporter
HB776_06105	COG1671	Belongs to the UPF0178 family
HB776_06135	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_06155	COG0416	fatty acid biosynthetic process
HB776_06160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HB776_06165	COG0776	regulation of translation
HB776_06235	COG1612	heme a metabolic process
HB776_06240	COG0672	)-iron permease
HB776_06255	COG1024	Enoyl-CoA hydratase
HB776_06265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HB776_06270	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HB776_06290	COG0628	permease
HB776_06300	COG0174	glutamine synthetase
HB776_06305	COG0347	Belongs to the P(II) protein family
HB776_06310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HB776_06310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HB776_06325	COG0544	peptidyl-prolyl cis-trans isomerase activity
HB776_06330	COG0740	serine-type endopeptidase activity
HB776_06335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HB776_06360	COG3916	Acyl-homoserine-lactone synthase
HB776_06365	COG2197	response regulator
HB776_06375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB776_06380	COG2195	Cleaves the N-terminal amino acid of tripeptides
HB776_06385	COG0776	regulation of translation
HB776_06410	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB776_06420	COG0649	NAD binding
HB776_06440	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HB776_06450	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HB776_06465	COG0713	ATP synthesis coupled electron transport
HB776_06480	COG1007	ATP synthesis coupled electron transport
HB776_06495	COG0346	lactoylglutathione lyase activity
HB776_06510	COG0442	prolyl-tRNA aminoacylation
HB776_06520	COG1136	(ABC) transporter
HB776_06535	COG0052	Belongs to the universal ribosomal protein uS2 family
HB776_06540	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HB776_06545	COG0528	UMP kinase activity
HB776_06550	COG0233	cytoplasmic translational termination
HB776_06555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HB776_06565	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HB776_06570	COG0750	zinc metalloprotease
HB776_06575	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB776_06580	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB776_06585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HB776_06590	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB776_06600	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB776_06605	COG0372	Belongs to the citrate synthase family
HB776_06610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB776_06615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB776_06625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB776_06630	COG0456	acetyltransferase
HB776_06635	COG1982	Orn Lys Arg decarboxylase major
HB776_06660	COG1011	Hydrolase
HB776_06670	COG2124	cytochrome p450
HB776_06700	COG0315	cyclic pyranopterin monophosphate synthase activity
HB776_06705	COG0134	indole-3-glycerol-phosphate synthase activity
HB776_06710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HB776_06730	COG0149	triose-phosphate isomerase activity
HB776_06740	COG0504	CTP synthase activity
HB776_06780	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HB776_06790	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HB776_06815	COG2020	methyltransferase activity
HB776_06840	COG0431	NADPH-dependent FMN reductase
HB776_06850	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB776_06855	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB776_06855	COG0022	dehydrogenase e1 component
HB776_06865	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB776_06875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB776_06885	COG0129	dihydroxy-acid dehydratase activity
HB776_06890	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HB776_06920	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HB776_06925	COG0018	arginyl-trna synthetase
HB776_06935	COG1472	Belongs to the glycosyl hydrolase 3 family
HB776_06940	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HB776_06945	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HB776_06950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HB776_06955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HB776_06960	COG0805	protein transport
HB776_06970	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HB776_06980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HB776_06990	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HB776_07000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HB776_07010	COG1862	Preprotein translocase
HB776_07015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB776_07040	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HB776_07085	COG0546	phosphoglycolate phosphatase activity
HB776_07100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HB776_07115	COG0629	single-stranded DNA binding
HB776_07140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HB776_07145	COG1335	isochorismatase
HB776_07150	COG0583	DNA-binding transcription factor activity
HB776_07155	COG3158	transport of potassium into the cell
HB776_07190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HB776_07195	COG0343	queuine tRNA-ribosyltransferase activity
HB776_07220	COG0697	spore germination
HB776_07270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HB776_07280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HB776_07300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HB776_07335	COG0679	Auxin Efflux Carrier
HB776_07340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB776_07345	COG1183	phosphatidylcholine synthase activity
HB776_07350	COG1253	flavin adenine dinucleotide binding
HB776_07360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HB776_07365	COG3707	response regulator
HB776_07370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_07370	COG1116	anion transmembrane transporter activity
HB776_07375	COG0175	sulfate reduction
HB776_07390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB776_07410	COG1116	anion transmembrane transporter activity
HB776_07415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_07420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_07430	COG1960	acyl-CoA dehydrogenase activity
HB776_07435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_07445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB776_07450	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HB776_07455	COG1984	allophanate hydrolase subunit 2
HB776_07465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB776_07475	COG1522	sequence-specific DNA binding
HB776_07480	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HB776_07500	COG0154	amidase activity
HB776_07505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB776_07600	COG1686	Belongs to the peptidase S11 family
HB776_07605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HB776_07615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB776_07620	COG0084	hydrolase, TatD family'
HB776_07625	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HB776_07625	COG0321	lipoyl(octanoyl) transferase activity
HB776_07635	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_07640	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HB776_07645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB776_07650	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_07690	COG4459	periplasmic nitrate reductase
HB776_07700	COG0243	molybdopterin cofactor binding
HB776_07710	COG3005	denitrification pathway
HB776_07745	COG0588	phosphoglycerate mutase activity
HB776_07765	COG0038	chloride channel
HB776_07775	COG1595	DNA-templated transcription, initiation
HB776_07815	COG0813	purine-nucleoside phosphorylase activity
HB776_07855	COG2059	Chromate
HB776_07930	COG0277	FAD linked oxidase domain protein
HB776_07935	COG2186	Transcriptional regulator
HB776_07940	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_07945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB776_07950	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HB776_07955	COG3956	TIGRFAM MazG family protein
HB776_07965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HB776_07970	COG1923	regulation of RNA biosynthetic process
HB776_07980	COG2204	response regulator
HB776_07985	COG5000	phosphorelay sensor kinase activity
HB776_08005	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HB776_08005	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HB776_08015	COG2867	negative regulation of translational initiation
HB776_08020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB776_08025	COG2094	Belongs to the DNA glycosylase MPG family
HB776_08035	COG0525	valine-tRNA ligase activity
HB776_08050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HB776_08075	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_08080	COG0823	Involved in the tonB-independent uptake of proteins
HB776_08115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB776_08135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HB776_08145	COG1126	abc transporter atp-binding protein
HB776_08150	COG0765	amino acid transport
HB776_08155	COG4597	amino acid ABC transporter
HB776_08160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB776_08165	COG0626	cystathionine gamma-synthase activity
HB776_08175	COG0463	Glycosyl transferase, family 2
HB776_08190	COG4953	penicillin-binding protein 1C
HB776_08195	COG2373	Large extracellular alpha-helical protein
HB776_08225	COG4191	Histidine kinase
HB776_08225	COG0784	Response regulator, receiver
HB776_08245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB776_08270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB776_08305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB776_08320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB776_08350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HB776_08445	COG0625	glutathione transferase activity
HB776_08565	COG1509	lysine 2,3-aminomutase activity
HB776_08570	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HB776_08575	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HB776_08585	COG0114	fumarate hydratase activity
HB776_08595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB776_08600	COG2188	Transcriptional regulator
HB776_08610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HB776_08615	COG0546	phosphoglycolate phosphatase activity
HB776_08635	COG0436	Aminotransferase
HB776_08645	COG3243	poly(R)-hydroxyalkanoic acid synthase
HB776_08655	COG2066	Belongs to the glutaminase family
HB776_08665	COG0174	glutamine synthetase
HB776_08675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HB776_08695	COG0586	Pfam SNARE associated Golgi protein
HB776_08715	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_08720	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_08725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB776_08755	COG3706	GGDEF domain
HB776_08765	COG0316	Belongs to the HesB IscA family
HB776_08775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB776_08780	COG0719	Fe-S assembly protein
HB776_08785	COG0396	ATPase activity
HB776_08800	COG1104	cysteine desulfurase activity
HB776_08805	COG2945	thiolester hydrolase activity
HB776_08815	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HB776_08820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HB776_08840	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_08870	COG2192	nodulation
HB776_08880	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB776_08905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HB776_08910	COG0860	N-Acetylmuramoyl-L-alanine amidase
HB776_08915	COG1530	ribonuclease E activity
HB776_08915	COG1530	ribonuclease E activity
HB776_08920	COG1301	dicarboxylic acid transport
HB776_08925	COG1268	BioY protein
HB776_08930	COG0436	Aminotransferase
HB776_08960	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HB776_08980	COG4993	Dehydrogenase
HB776_09000	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HB776_09015	COG5002	protein histidine kinase activity
HB776_09020	COG0784	Response regulator, receiver
HB776_09025	COG3920	Histidine kinase
HB776_09055	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HB776_09060	COG0471	metal ion transport
HB776_09065	COG1252	NADH dehydrogenase
HB776_09070	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HB776_09085	COG0657	acetylesterase activity
HB776_09100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB776_09105	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HB776_09135	COG2205	protein histidine kinase activity
HB776_09145	COG3038	cytochrome b561
HB776_09150	COG0697	spore germination
HB776_09155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB776_09165	COG3621	Patatin-like phospholipase
HB776_09235	COG1335	isochorismatase
HB776_09255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_09260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_09265	COG1116	anion transmembrane transporter activity
HB776_09290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_09295	COG1228	amidohydrolase
HB776_09300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HB776_09305	COG0154	amidase activity
HB776_09315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_09325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_09335	COG1053	succinate dehydrogenase
HB776_09350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB776_09355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_09360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_09375	COG1522	sequence-specific DNA binding
HB776_09380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_09385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_09390	COG1116	anion transmembrane transporter activity
HB776_09410	COG1396	sequence-specific DNA binding
HB776_09455	COG2897	thiosulfate sulfurtransferase activity
HB776_09495	COG0412	Dienelactone hydrolase
HB776_09510	COG1464	Belongs to the NlpA lipoprotein family
HB776_09515	COG4608	Belongs to the ABC transporter superfamily
HB776_09520	COG0444	Belongs to the ABC transporter superfamily
HB776_09525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_09530	COG0601	transmembrane transport
HB776_09535	COG0747	negative chemotaxis
HB776_09600	COG0183	Belongs to the thiolase family
HB776_09610	COG1960	acyl-CoA dehydrogenase activity
HB776_09620	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_09640	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_09655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_09665	COG1024	Enoyl-CoA hydratase
HB776_09685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_09700	COG1304	FMN binding
HB776_09765	COG2837	iron assimilation
HB776_09815	COG1309	transcriptional regulator
HB776_09825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HB776_09860	COG0625	glutathione transferase activity
HB776_09875	COG4753	response regulator
HB776_09875	COG2207	Transcriptional regulator
HB776_09895	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_09935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_09945	COG2814	Major facilitator Superfamily
HB776_09950	COG2814	Major facilitator Superfamily
HB776_09955	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_09960	COG0513	Belongs to the DEAD box helicase family
HB776_09965	COG1285	pathogenesis
HB776_10050	COG0386	Belongs to the glutathione peroxidase family
HB776_10070	COG0281	malic enzyme
HB776_10070	COG0280	phosphate acetyltransferase
HB776_10075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HB776_10090	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HB776_10095	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HB776_10105	COG0248	Ppx GppA phosphatase
HB776_10110	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HB776_10125	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HB776_10130	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HB776_10140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB776_10150	COG1309	transcriptional regulator
HB776_10155	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HB776_10165	COG1278	Cold shock
HB776_10175	COG0861	Integral membrane protein TerC family
HB776_10180	COG0105	UTP biosynthetic process
HB776_10195	COG0488	(ABC) transporter
HB776_10210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HB776_10225	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HB776_10235	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HB776_10240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HB776_10275	COG1178	ABC-type Fe3 transport system permease component
HB776_10285	COG3842	ATPase activity
HB776_10300	COG0194	GDP metabolic process
HB776_10305	COG1561	YicC-like family, N-terminal region
HB776_10310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HB776_10315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB776_10330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HB776_10335	COG0360	Binds together with S18 to 16S ribosomal RNA
HB776_10340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HB776_10350	COG0359	binds to the 23S rRNA
HB776_10360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HB776_10370	COG0305	Participates in initiation and elongation during chromosome replication
HB776_10375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB776_10415	COG1286	toxin biosynthetic process
HB776_10420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HB776_10425	COG0300	oxidoreductase activity
HB776_10470	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
HB776_10475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_10490	COG2020	methyltransferase activity
HB776_10515	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HB776_10525	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_10575	COG0306	phosphate transporter
HB776_10580	COG1392	Phosphate transport regulator
HB776_10585	COG4214	carbohydrate transport
HB776_10590	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_10620	COG1393	Belongs to the ArsC family
HB776_10630	COG1846	Transcriptional regulator
HB776_10640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HB776_10650	COG1418	mRNA catabolic process
HB776_10660	COG0596	Alpha beta hydrolase
HB776_10670	COG0242	peptide deformylase activity
HB776_10700	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB776_10765	COG1049	propionate catabolic process, 2-methylcitrate cycle
HB776_10775	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_10785	COG0698	ribose 5-phosphate isomerase
HB776_10790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB776_10790	COG0519	Catalyzes the synthesis of GMP from XMP
HB776_10815	COG2130	NADP-dependent
HB776_10845	COG1309	transcriptional regulator
HB776_10850	COG0697	spore germination
HB776_10855	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HB776_10880	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HB776_10885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HB776_10890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HB776_10900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB776_10900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB776_10905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HB776_10910	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HB776_10945	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_10955	COG0113	porphobilinogen synthase activity
HB776_10985	COG1914	H( )-stimulated, divalent metal cation uptake system
HB776_10995	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HB776_11010	COG2814	Major facilitator Superfamily
HB776_11025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_11030	COG1253	flavin adenine dinucleotide binding
HB776_11050	COG1393	Belongs to the ArsC family
HB776_11055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HB776_11090	COG1381	Involved in DNA repair and RecF pathway recombination
HB776_11100	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HB776_11105	COG0571	ribonuclease III activity
HB776_11110	COG0681	Belongs to the peptidase S26 family
HB776_11115	COG0736	holo-[acyl-carrier-protein] synthase activity
HB776_11120	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HB776_11130	COG1758	RNA polymerase activity
HB776_11150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HB776_11155	COG1970	mechanosensitive ion channel activity
HB776_11160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB776_11165	COG0741	lytic transglycosylase activity
HB776_11185	COG1335	isochorismatase
HB776_11200	COG2207	Transcriptional regulator
HB776_11220	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB776_11230	COG3920	Histidine kinase
HB776_11235	COG0154	amidase activity
HB776_11245	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB776_11270	COG0679	Auxin Efflux Carrier
HB776_11280	COG1960	acyl-CoA dehydrogenase activity
HB776_11290	COG1309	transcriptional regulator
HB776_11295	COG2814	Major facilitator Superfamily
HB776_11300	COG0540	Belongs to the ATCase OTCase family
HB776_11305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB776_11310	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HB776_11315	COG0789	Transcriptional regulator
HB776_11320	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB776_11335	COG1733	regulation of RNA biosynthetic process
HB776_11340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HB776_11345	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_11360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HB776_11365	COG0557	exoribonuclease II activity
HB776_11390	COG0583	DNA-binding transcription factor activity
HB776_11395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_11400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HB776_11415	COG0784	Response regulator, receiver
HB776_11425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB776_11435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB776_11470	COG0537	adenosine 5'-monophosphoramidase activity
HB776_11475	COG1720	tRNA m6t6A37 methyltransferase activity
HB776_11515	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HB776_11530	COG1686	Belongs to the peptidase S11 family
HB776_11550	COG1192	Involved in chromosome partitioning
HB776_11555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HB776_11570	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HB776_11600	COG2267	carboxylic ester hydrolase activity
HB776_11615	COG2860	membrane
HB776_11655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB776_11680	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HB776_11700	COG0778	Nitroreductase
HB776_11710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HB776_11715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB776_11720	COG1733	regulation of RNA biosynthetic process
HB776_11735	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_11740	COG0203	ribosomal protein L17
HB776_11745	COG0202	RNA polymerase activity
HB776_11750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HB776_11755	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HB776_11760	COG0563	adenylate kinase activity
HB776_11765	COG0201	protein transport
HB776_11770	COG0200	Binds to the 23S rRNA
HB776_11775	COG1841	ribosomal large subunit assembly
HB776_11780	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HB776_11785	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HB776_11790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HB776_11795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HB776_11800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HB776_11805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HB776_11810	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HB776_11815	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HB776_11820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HB776_11825	COG0255	Belongs to the universal ribosomal protein uL29 family
HB776_11830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HB776_11835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HB776_11840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HB776_11845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HB776_11850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HB776_11855	COG0089	rRNA binding
HB776_11860	COG0088	Forms part of the polypeptide exit tunnel
HB776_11865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HB776_11870	COG0051	transcription antitermination factor activity, RNA binding
HB776_11875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HB776_11880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HB776_11890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HB776_11895	COG0251	oxidation-reduction process
HB776_11905	COG1132	(ABC) transporter
HB776_11910	COG1231	oxidoreductase activity
HB776_11920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HB776_11925	COG0085	RNA polymerase activity
HB776_11930	COG0222	ribosome binding
HB776_11935	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HB776_11970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB776_11975	COG0081	regulation of translation
HB776_11980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HB776_11990	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HB776_12010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HB776_12055	COG1960	acyl-CoA dehydrogenase activity
HB776_12095	COG1464	Belongs to the NlpA lipoprotein family
HB776_12100	COG2011	ABC-type metal ion transport system permease component
HB776_12105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB776_12110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_12115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_12130	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HB776_12140	COG2723	6-phospho-beta-galactosidase activity
HB776_12145	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB776_12160	COG4149	molybdate abc transporter
HB776_12185	COG3706	GGDEF domain
HB776_12205	COG1063	alcohol dehydrogenase
HB776_12210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB776_12220	COG3842	ATPase activity
HB776_12225	COG1177	transmembrane transport
HB776_12230	COG1176	ABC-type spermidine putrescine transport system, permease component I
HB776_12245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB776_12260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB776_12290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HB776_12310	COG3258	Cytochrome c
HB776_12315	COG2010	Cytochrome c
HB776_12330	COG0785	Cytochrome C biogenesis protein
HB776_12340	COG0640	Transcriptional regulator
HB776_12360	COG2391	methyltransferase activity
HB776_12470	COG0783	Belongs to the Dps family
HB776_12480	COG0596	Alpha beta hydrolase
HB776_12490	COG1275	C4-dicarboxylate transporter malic acid transport protein
HB776_12505	COG2207	Transcriptional regulator
HB776_12560	COG2149	membrane
HB776_12580	COG3258	Cytochrome c
HB776_12595	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_12655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HB776_12685	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HB776_12690	COG0302	gtp cyclohydrolase
HB776_12710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HB776_12725	COG2814	Major facilitator Superfamily
HB776_12730	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HB776_12745	COG5001	Diguanylate cyclase
HB776_12755	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB776_12850	COG2197	response regulator
HB776_12865	COG2267	carboxylic ester hydrolase activity
HB776_12895	COG1349	DNA-binding transcription factor activity
HB776_12900	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HB776_12905	COG3395	kinase activity
HB776_12925	COG0477	Major facilitator Superfamily
HB776_12930	COG0251	oxidation-reduction process
HB776_12945	COG0747	negative chemotaxis
HB776_12950	COG0747	negative chemotaxis
HB776_12960	COG0601	transmembrane transport
HB776_12965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_12980	COG1473	amidohydrolase
HB776_12985	COG1024	Enoyl-CoA hydratase
HB776_13005	COG0625	glutathione transferase activity
HB776_13010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HB776_13020	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HB776_13025	COG1546	Belongs to the CinA family
HB776_13025	COG1058	Belongs to the CinA family
HB776_13030	COG2308	Evidence 4 Homologs of previously reported genes of
HB776_13055	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_13060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HB776_13075	COG5425	PFAM Usg family protein
HB776_13080	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HB776_13085	COG0459	protein refolding
HB776_13090	COG0251	oxidation-reduction process
HB776_13095	COG0640	Transcriptional regulator
HB776_13100	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_13160	COG1959	2 iron, 2 sulfur cluster binding
HB776_13175	COG3186	Phenylalanine-4-hydroxylase
HB776_13185	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HB776_13195	COG0463	Glycosyl transferase, family 2
HB776_13235	COG2068	MobA-Related Protein
HB776_13240	COG3608	succinylglutamate desuccinylase aspartoacylase
HB776_13240	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HB776_13275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB776_13285	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB776_13345	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HB776_13350	COG0785	Cytochrome C biogenesis protein
HB776_13355	COG3191	aminopeptidase activity
HB776_13385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB776_13410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HB776_13415	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HB776_13430	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HB776_13440	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB776_13445	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HB776_13465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB776_13470	COG2197	response regulator
HB776_13480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB776_13495	COG0384	phenazine biosynthesis protein PhzF
HB776_13505	COG4829	muconolactone delta-isomerase
HB776_13525	COG0583	DNA-binding transcription factor activity
HB776_13535	COG2610	gluconate transmembrane transporter activity
HB776_13545	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_13550	COG0047	phosphoribosylformylglycinamidine synthase activity
HB776_13555	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB776_13560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HB776_13570	COG4774	siderophore transport
HB776_13580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_13600	COG3708	Transcriptional regulator
HB776_13600	COG2207	Transcriptional regulator
HB776_13610	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HB776_13615	COG1116	anion transmembrane transporter activity
HB776_13615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_13620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_13625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_13665	COG0538	isocitrate dehydrogenase activity
HB776_13670	COG1505	serine-type exopeptidase activity
HB776_13680	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_13685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB776_13685	COG4651	solute:proton antiporter activity
HB776_13690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HB776_13695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HB776_13700	COG0509	glycine decarboxylation via glycine cleavage system
HB776_13705	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HB776_13705	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HB776_13710	COG3685	Protein conserved in bacteria
HB776_13715	COG1473	amidohydrolase
HB776_13740	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HB776_13750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HB776_13755	COG1657	PFAM Prenyltransferase squalene oxidase
HB776_13760	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HB776_13765	COG1562	ergosterol biosynthetic process
HB776_13770	COG1562	ergosterol biosynthetic process
HB776_13800	COG4303	Ethanolamine ammonia lyase large subunit
HB776_13805	COG2081	HI0933 family
HB776_13825	COG2721	sulfolactate sulfo-lyase activity
HB776_13830	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_13860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_13865	COG1846	Transcriptional regulator
HB776_13875	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HB776_13900	COG1846	Transcriptional regulator
HB776_13905	COG3971	2-oxopent-4-enoate hydratase activity
HB776_13925	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB776_13930	COG0028	Belongs to the TPP enzyme family
HB776_13945	COG3145	DNA-N1-methyladenine dioxygenase activity
HB776_13980	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_13985	COG0477	Major facilitator Superfamily
HB776_14000	COG3386	PFAM SMP-30 Gluconolaconase
HB776_14005	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HB776_14030	COG1024	Enoyl-CoA hydratase
HB776_14075	COG2267	carboxylic ester hydrolase activity
HB776_14080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB776_14080	COG2124	cytochrome p450
HB776_14095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_14100	COG0747	negative chemotaxis
HB776_14110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_14115	COG0444	Belongs to the ABC transporter superfamily
HB776_14120	COG4608	Belongs to the ABC transporter superfamily
HB776_14125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HB776_14240	COG2917	probably involved in intracellular septation
HB776_14260	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HB776_14260	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HB776_14300	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HB776_14305	COG1684	flagellar biosynthetic protein fliR
HB776_14310	COG1987	bacterial-type flagellum assembly
HB776_14315	COG1677	Flagellar hook-basal body complex protein FliE
HB776_14320	COG1558	bacterial-type flagellum-dependent cell motility
HB776_14335	COG1338	Plays a role in the flagellum-specific transport system
HB776_14365	COG4786	Flagellar basal body rod
HB776_14370	COG4786	Flagellar basal body rod
HB776_14385	COG3971	2-oxopent-4-enoate hydratase activity
HB776_14405	COG1706	bacterial-type flagellum-dependent cell motility
HB776_14455	COG1256	bacterial-type flagellum assembly
HB776_14460	COG1749	Flagellar hook protein flgE
HB776_14465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HB776_14470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_14470	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HB776_14495	COG3685	Protein conserved in bacteria
HB776_14510	COG0477	Major facilitator Superfamily
HB776_14515	COG0583	DNA-binding transcription factor activity
HB776_14530	COG0492	ferredoxin-NADP+ reductase activity
HB776_14540	COG0633	Ferredoxin
HB776_14565	COG3218	ABC-type transport auxiliary lipoprotein component
HB776_14565	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HB776_14570	COG1127	ABC transporter
HB776_14575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HB776_14580	COG4948	Mandelate Racemase Muconate Lactonizing
HB776_14585	COG2814	Major facilitator Superfamily
HB776_14600	COG0438	transferase activity, transferring glycosyl groups
HB776_14655	COG0351	phosphomethylpyrimidine kinase
HB776_14670	COG1522	sequence-specific DNA binding
HB776_14675	COG5001	Diguanylate cyclase
HB776_14675	COG3300	MHYT domain
HB776_14680	COG0697	spore germination
HB776_14685	COG0656	L-ascorbic acid biosynthetic process
HB776_14705	COG1129	ABC transporter
HB776_14725	COG2198	Histidine kinase
HB776_14725	COG5002	protein histidine kinase activity
HB776_14725	COG0784	Response regulator, receiver
HB776_14730	COG0745	RESPONSE REGULATOR receiver
HB776_14740	COG1053	succinate dehydrogenase
HB776_14745	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_14765	COG1653	transport
HB776_14775	COG3833	ABC-type maltose transport systems, permease component
HB776_14780	COG0243	molybdopterin cofactor binding
HB776_14785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB776_14800	COG1116	anion transmembrane transporter activity
HB776_14805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_14810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_14820	COG3485	protocatechuate 3,4-dioxygenase
HB776_14830	COG1396	sequence-specific DNA binding
HB776_14835	COG1301	dicarboxylic acid transport
HB776_14850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB776_14870	COG3845	ABC transporter
HB776_14875	COG4603	Belongs to the binding-protein-dependent transport system permease family
HB776_14905	COG2080	2 iron, 2 sulfur cluster binding
HB776_14905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB776_14955	COG2267	carboxylic ester hydrolase activity
HB776_14965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB776_14970	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HB776_14990	COG1492	cobalamin metabolic process
HB776_15025	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HB776_15035	COG5001	Diguanylate cyclase
HB776_15035	COG3300	MHYT domain
HB776_15045	COG4221	oxidoreductase activity
HB776_15050	COG1960	acyl-CoA dehydrogenase activity
HB776_15070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_15075	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HB776_15095	COG1272	protein, Hemolysin III
HB776_15100	COG3106	COG3106 Predicted ATPase
HB776_15105	COG3768	UPF0283 membrane protein
HB776_15115	COG0640	Transcriptional regulator
HB776_15135	COG1278	Cold shock
HB776_15160	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HB776_15180	COG0625	glutathione transferase activity
HB776_15195	COG1704	LemA family
HB776_15200	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_15215	COG2814	Major facilitator Superfamily
HB776_15220	COG0297	glycogen (starch) synthase activity
HB776_15260	COG0583	DNA-binding transcription factor activity
HB776_15275	COG4771	TonB-dependent receptor
HB776_15285	COG4558	Periplasmic binding protein
HB776_15290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB776_15295	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HB776_15305	COG0402	S-adenosylhomocysteine deaminase activity
HB776_15310	COG2072	flavoprotein involved in K transport
HB776_15315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_15355	COG1012	belongs to the aldehyde dehydrogenase family
HB776_15395	COG0297	glycogen (starch) synthase activity
HB776_15445	COG1228	amidohydrolase
HB776_15450	COG0683	leucine binding
HB776_15460	COG4638	Rieske (2fe-2S)
HB776_15495	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HB776_15500	COG3454	Phosphonate metabolism
HB776_15505	COG4778	phosphonate C-P lyase system protein PhnL
HB776_15510	COG4107	phosphonate C-P lyase system protein PhnK
HB776_15515	COG3627	carbon phosphorus lyase activity
HB776_15520	COG3626	phosphonate metabolism
HB776_15525	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HB776_15530	COG3624	Phosphonate C-P lyase system protein PhnG
HB776_15535	COG2188	Transcriptional regulator
HB776_15545	COG0824	Thioesterase
HB776_15555	COG3321	synthase
HB776_15555	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_15555	COG0604	alcohol dehydrogenase
HB776_15565	COG1615	UPF0182 protein
HB776_15580	COG2255	four-way junction helicase activity
HB776_15590	COG0632	four-way junction helicase activity
HB776_15595	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HB776_15610	COG0840	transmembrane signaling receptor activity
HB776_15635	COG1692	metallophosphoesterase
HB776_15640	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HB776_15670	COG0126	phosphoglycerate kinase activity
HB776_15685	COG3588	fructose-bisphosphate aldolase
HB776_15690	COG0352	thiamine-phosphate diphosphorylase activity
HB776_15700	COG0483	inositol monophosphate 1-phosphatase activity
HB776_15710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_15730	COG1132	(ABC) transporter
HB776_15735	COG0254	rRNA binding
HB776_15750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HB776_15750	COG2755	lipolytic protein G-D-S-L family
HB776_15765	COG0604	alcohol dehydrogenase
HB776_15790	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_15805	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HB776_15810	COG4208	sulfate ABC transporter
HB776_15815	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HB776_15830	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB776_15840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HB776_15840	COG1648	precorrin-2 dehydrogenase activity
HB776_15855	COG4208	sulfate ABC transporter
HB776_15860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HB776_15870	COG0840	transmembrane signaling receptor activity
HB776_15885	COG1388	LysM domain
HB776_15885	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_15890	COG0628	permease
HB776_15925	COG0583	DNA-binding transcription factor activity
HB776_15935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_15940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_15950	COG0784	Response regulator, receiver
HB776_16030	COG0300	oxidoreductase activity
HB776_16030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB776_16030	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_16030	COG3321	synthase
HB776_16030	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_16035	COG1024	Enoyl-CoA hydratase
HB776_16125	COG1024	Enoyl-CoA hydratase
HB776_16135	COG1960	acyl-CoA dehydrogenase activity
HB776_16140	COG1960	acyl-CoA dehydrogenase activity
HB776_16150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB776_16180	COG1797	cobyrinic acid a,c-diamide synthase activity
HB776_16195	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HB776_16215	COG0406	alpha-ribazole phosphatase activity
HB776_16220	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HB776_16245	COG0259	pyridoxamine-phosphate oxidase activity
HB776_16250	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_16255	COG0598	Magnesium transport protein CorA
HB776_16260	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_16260	COG1388	LysM domain
HB776_16270	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_16285	COG0505	Belongs to the CarA family
HB776_16295	COG3258	Cytochrome c
HB776_16315	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB776_16330	COG2080	2 iron, 2 sulfur cluster binding
HB776_16340	COG3800	Transcriptional regulator
HB776_16340	COG1396	sequence-specific DNA binding
HB776_16360	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB776_16365	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB776_16370	COG1129	ABC transporter
HB776_16375	COG0277	FAD linked oxidase domain protein
HB776_16380	COG3485	protocatechuate 3,4-dioxygenase
HB776_16385	COG2084	Dehydrogenase
HB776_16390	COG0402	S-adenosylhomocysteine deaminase activity
HB776_16400	COG1609	Transcriptional regulator
HB776_16420	COG1129	ABC transporter
HB776_16425	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB776_16430	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB776_16435	COG1879	ABC-type sugar transport system periplasmic component
HB776_16465	COG3485	protocatechuate 3,4-dioxygenase
HB776_16470	COG1609	Transcriptional regulator
HB776_16485	COG3246	L-lysine catabolic process to acetate
HB776_16490	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB776_16495	COG1129	ABC transporter
HB776_16535	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_16545	COG1024	Enoyl-CoA hydratase
HB776_16550	COG2050	protein possibly involved in aromatic compounds catabolism
HB776_16565	COG1012	belongs to the aldehyde dehydrogenase family
HB776_16565	COG2030	dehydratase
HB776_16585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB776_16590	COG2151	metal-sulfur cluster biosynthetic enzyme
HB776_16595	COG3396	Phenylacetate-CoA oxygenase
HB776_16600	COG3460	Phenylacetate-CoA oxygenase
HB776_16605	COG3396	Phenylacetate-CoA oxygenase
HB776_16610	COG3327	negative regulation of DNA-templated transcription, initiation
HB776_16695	COG3237	CsbD-like
HB776_16725	COG0784	Response regulator, receiver
HB776_16725	COG4191	Histidine kinase
HB776_16740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB776_16745	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HB776_16750	COG2080	2 iron, 2 sulfur cluster binding
HB776_16755	COG1335	isochorismatase
HB776_16795	COG0784	Response regulator, receiver
HB776_16795	COG4191	Histidine kinase
HB776_16890	COG2943	transferase activity, transferring hexosyl groups
HB776_16895	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HB776_16970	COG0628	permease
HB776_16980	COG1278	Cold shock
HB776_17080	COG0776	regulation of translation
HB776_17095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HB776_17170	COG3920	Histidine kinase
HB776_17185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB776_17195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB776_17205	COG0702	epimerase
HB776_17245	COG3920	Histidine kinase
HB776_17280	COG4191	Histidine kinase
HB776_17280	COG0784	Response regulator, receiver
HB776_17300	COG0588	phosphoglycerate mutase activity
HB776_17315	COG0038	chloride channel
HB776_17340	COG1012	belongs to the aldehyde dehydrogenase family
HB776_17365	COG1063	alcohol dehydrogenase
HB776_17390	COG1175	transmembrane transport
HB776_17400	COG1653	transport
HB776_17415	COG0456	acetyltransferase
HB776_17415	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HB776_17430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HB776_17445	COG1609	Transcriptional regulator
HB776_17455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB776_17460	COG1175	transmembrane transport
HB776_17505	COG1396	sequence-specific DNA binding
HB776_17520	COG0028	Belongs to the TPP enzyme family
HB776_17525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB776_17540	COG0604	alcohol dehydrogenase
HB776_17555	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB776_17555	COG0596	Alpha beta hydrolase
HB776_17560	COG0431	NADPH-dependent FMN reductase
HB776_17565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_17585	COG2188	Transcriptional regulator
HB776_17600	COG1012	belongs to the aldehyde dehydrogenase family
HB776_17615	COG1733	regulation of RNA biosynthetic process
HB776_17620	COG0702	epimerase
HB776_17665	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_17680	COG1802	Transcriptional regulator
HB776_17685	COG2186	Transcriptional regulator
HB776_17705	COG3052	prosthetic group binding
HB776_17740	COG1126	abc transporter atp-binding protein
HB776_17745	COG0765	amino acid transport
HB776_17760	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HB776_17770	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HB776_17800	COG4948	Mandelate Racemase Muconate Lactonizing
HB776_17835	COG3958	Transketolase
HB776_17840	COG3959	Transketolase, thiamine diphosphate binding domain
HB776_17845	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_17850	COG0583	DNA-binding transcription factor activity
HB776_17860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB776_17870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB776_17880	COG0154	amidase activity
HB776_17900	COG0683	leucine binding
HB776_17910	COG0402	S-adenosylhomocysteine deaminase activity
HB776_17925	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_17935	COG1228	amidohydrolase
HB776_17960	COG4214	carbohydrate transport
HB776_18060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB776_18070	COG1129	ABC transporter
HB776_18080	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB776_18085	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_18110	COG3971	2-oxopent-4-enoate hydratase activity
HB776_18115	COG3485	protocatechuate 3,4-dioxygenase
HB776_18120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HB776_18140	COG2814	Major facilitator Superfamily
HB776_18145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HB776_18150	COG2197	response regulator
HB776_18155	COG3916	Acyl-homoserine-lactone synthase
HB776_18205	COG2755	lipolytic protein G-D-S-L family
HB776_18205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HB776_18215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB776_18225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HB776_18240	COG0582	viral genome integration into host DNA
HB776_18250	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HB776_18255	COG0424	maF-like protein
HB776_18260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB776_18265	COG5328	Belongs to the UPF0262 family
HB776_18270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HB776_18280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB776_18315	COG3634	alkyl hydroperoxide reductase activity
HB776_18330	COG1522	sequence-specific DNA binding
HB776_18335	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_18340	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_18345	COG4608	Belongs to the ABC transporter superfamily
HB776_18350	COG0444	Belongs to the ABC transporter superfamily
HB776_18355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_18360	COG0601	transmembrane transport
HB776_18390	COG1794	racemase activity, acting on amino acids and derivatives
HB776_18425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB776_18430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HB776_18480	COG0765	amino acid transport
HB776_18485	COG0765	amino acid transport
HB776_18490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB776_18500	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HB776_18530	COG1278	Cold shock
HB776_18595	COG4451	ribulose bisphosphate carboxylase, small
HB776_18600	COG1850	ribulose-bisphosphate carboxylase activity
HB776_18620	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HB776_18640	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_18650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB776_18665	COG0747	negative chemotaxis
HB776_18675	COG3218	ABC-type transport auxiliary lipoprotein component
HB776_18675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HB776_18680	COG1127	ABC transporter
HB776_18695	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HB776_18700	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HB776_18720	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HB776_18725	COG4177	L-phenylalanine transmembrane transporter activity
HB776_18755	COG0251	oxidation-reduction process
HB776_18770	COG1126	abc transporter atp-binding protein
HB776_18780	COG3791	Glutathione-dependent formaldehyde-activating
HB776_18785	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB776_18860	COG0583	DNA-binding transcription factor activity
HB776_18880	COG1131	(ABC) transporter
HB776_18900	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HB776_18925	COG1960	acyl-CoA dehydrogenase activity
HB776_18930	COG1024	Enoyl-CoA hydratase
HB776_18935	COG0737	Belongs to the 5'-nucleotidase family
HB776_18935	COG4085	toxin activity
HB776_18935	COG1525	nuclease
HB776_18940	COG5002	protein histidine kinase activity
HB776_18940	COG5001	Diguanylate cyclase
HB776_18945	COG0123	including yeast histone deacetylase and acetoin utilization protein
HB776_18950	COG1722	exodeoxyribonuclease VII activity
HB776_18960	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HB776_18970	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HB776_18975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HB776_18980	COG2267	carboxylic ester hydrolase activity
HB776_18985	COG1960	acyl-CoA dehydrogenase activity
HB776_18995	COG1024	Enoyl-CoA hydratase
HB776_19000	COG0583	DNA-binding transcription factor activity
HB776_19005	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_19020	COG0583	DNA-binding transcription factor activity
HB776_19030	COG1058	Belongs to the CinA family
HB776_19030	COG1546	Belongs to the CinA family
HB776_19035	COG0444	Belongs to the ABC transporter superfamily
HB776_19040	COG0154	amidase activity
HB776_19050	COG4608	Belongs to the ABC transporter superfamily
HB776_19055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_19060	COG0601	transmembrane transport
HB776_19065	COG4166	transmembrane transport
HB776_19070	COG0747	negative chemotaxis
HB776_19075	COG0366	Alpha amylase catalytic
HB776_19085	COG0010	Belongs to the arginase family
HB776_19115	COG2205	protein histidine kinase activity
HB776_19115	COG0784	Response regulator, receiver
HB776_19125	COG0210	DNA helicase
HB776_19130	COG0583	DNA-binding transcription factor activity
HB776_19135	COG0346	lactoylglutathione lyase activity
HB776_19140	COG0400	carboxylic ester hydrolase activity
HB776_19155	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HB776_19165	COG5398	heme oxygenase
HB776_19170	COG0408	coproporphyrinogen oxidase activity
HB776_19175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HB776_19185	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB776_19210	COG0683	leucine binding
HB776_19220	COG1129	ABC transporter
HB776_19230	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HB776_19235	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB776_19250	COG1116	anion transmembrane transporter activity
HB776_19250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_19255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_19270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB776_19300	COG0583	DNA-binding transcription factor activity
HB776_19350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB776_19355	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB776_19360	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_19380	COG2814	Major facilitator Superfamily
HB776_19385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HB776_19390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB776_19400	COG1522	sequence-specific DNA binding
HB776_19405	COG0492	ferredoxin-NADP+ reductase activity
HB776_19410	COG0583	DNA-binding transcription factor activity
HB776_19420	COG1937	Protein conserved in bacteria
HB776_19425	COG3300	MHYT domain
HB776_19425	COG5001	Diguanylate cyclase
HB776_19430	COG1192	Involved in chromosome partitioning
HB776_19565	COG2205	protein histidine kinase activity
HB776_19585	COG0642	Histidine kinase
HB776_19595	COG4774	siderophore transport
HB776_19600	COG1840	ABC-type Fe3 transport system, periplasmic component
HB776_19635	COG1177	transmembrane transport
HB776_19640	COG1176	ABC-type spermidine putrescine transport system, permease component I
HB776_19645	COG3842	ATPase activity
HB776_19650	COG5001	Diguanylate cyclase
HB776_19650	COG3300	MHYT domain
HB776_19655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_19690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HB776_19695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HB776_19700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HB776_19720	COG0387	Pfam Sodium calcium exchanger
HB776_19780	COG0861	Integral membrane protein TerC family
HB776_19785	COG2204	response regulator
HB776_19790	COG2989	Protein conserved in bacteria
HB776_19795	COG3108	Peptidase M15
HB776_19820	COG1764	response to oxidative stress
HB776_19845	COG0668	transmembrane transport
HB776_19855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HB776_19860	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_19895	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HB776_19910	COG2186	Transcriptional regulator
HB776_19925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB776_19935	COG0596	Alpha beta hydrolase
HB776_19940	COG2733	membrane
HB776_19950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB776_19955	COG0354	folic acid binding
HB776_19960	COG0519	Catalyzes the synthesis of GMP from XMP
HB776_19965	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HB776_19985	COG0028	Belongs to the TPP enzyme family
HB776_19990	COG1116	anion transmembrane transporter activity
HB776_19995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_20005	COG0154	amidase activity
HB776_20020	COG1054	Belongs to the UPF0176 family
HB776_20025	COG2900	Belongs to the SlyX family
HB776_20030	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_20045	COG0181	hydroxymethylbilane synthase activity
HB776_20060	COG1902	pentaerythritol trinitrate reductase activity
HB776_20070	COG2192	nodulation
HB776_20100	COG1126	abc transporter atp-binding protein
HB776_20105	COG0765	amino acid transport
HB776_20110	COG0765	amino acid transport
HB776_20125	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HB776_20150	COG0483	inositol monophosphate 1-phosphatase activity
HB776_20155	COG0583	DNA-binding transcription factor activity
HB776_20165	COG1280	lysine exporter protein (LysE YggA)
HB776_20175	COG0071	Belongs to the small heat shock protein (HSP20) family
HB776_20185	COG0069	glutamate synthase activity
HB776_20185	COG0067	glutamate synthase
HB776_20185	COG0070	glutamate synthase
HB776_20220	COG3237	CsbD-like
HB776_20225	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_20230	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_20245	COG2951	lytic endotransglycosylase activity
HB776_20250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HB776_20255	COG2203	Gaf domain
HB776_20255	COG5001	Diguanylate cyclase
HB776_20255	COG4251	negative regulation of phosphorylation
HB776_20255	COG3706	GGDEF domain
HB776_20290	COG0330	HflC and HflK could
HB776_20295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HB776_20330	COG0251	oxidation-reduction process
HB776_20335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB776_20345	COG4689	acetoacetate decarboxylase
HB776_20365	COG0523	cobalamin synthesis protein
HB776_20370	COG0803	Belongs to the bacterial solute-binding protein 9 family
HB776_20380	COG1121	(ABC) transporter
HB776_20390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HB776_20395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HB776_20400	COG2271	Major facilitator Superfamily
HB776_20420	COG0174	glutamine synthetase
HB776_20425	COG0069	glutamate synthase activity
HB776_20430	COG2218	PFAM glutamate synthase alpha subunit domain protein
HB776_20435	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HB776_20450	COG2309	aminopeptidase activity
HB776_20460	COG2226	methyltransferase
HB776_20465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB776_20470	COG2146	nitrite reductase [NAD(P)H] activity
HB776_20475	COG2116	formate transmembrane transporter activity
HB776_20480	COG0515	serine threonine protein kinase
HB776_20480	COG2815	serine threonine protein kinase
HB776_20490	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_20500	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_20570	COG0739	heme binding
HB776_20575	COG0702	epimerase
HB776_20580	COG0542	response to heat
HB776_20595	COG2813	Specifically methylates the guanine in position
HB776_20595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB776_20600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB776_20610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HB776_20615	COG0287	Prephenate dehydrogenase
HB776_20645	COG2884	Cell division ATP-binding protein ftsE
HB776_20655	COG2204	response regulator
HB776_20665	COG0019	diaminopimelate decarboxylase activity
HB776_20675	COG0165	Argininosuccinate lyase
HB776_20680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB776_20685	COG5507	3-demethylubiquinone-9 3-methyltransferase
HB776_20710	COG0583	DNA-binding transcription factor activity
HB776_20715	COG1942	4-Oxalocrotonate Tautomerase
HB776_20720	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB776_20725	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HB776_20730	COG2086	electron transfer activity
HB776_20750	COG5002	protein histidine kinase activity
HB776_20750	COG2198	Histidine kinase
HB776_20750	COG0784	Response regulator, receiver
HB776_20755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB776_20760	COG0583	DNA-binding transcription factor activity
HB776_20765	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_20775	COG1388	LysM domain
HB776_20775	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_20780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HB776_20790	COG4772	TonB-dependent receptor
HB776_20800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB776_20815	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB776_20835	COG0038	chloride channel
HB776_20845	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_20850	COG1733	regulation of RNA biosynthetic process
HB776_20865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB776_20865	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HB776_20900	COG4774	siderophore transport
HB776_20915	COG0582	viral genome integration into host DNA
HB776_20945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_20955	COG0598	Magnesium transport protein CorA
HB776_20965	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_20975	COG0306	phosphate transporter
HB776_20990	COG0784	Response regulator, receiver
HB776_20990	COG4191	Histidine kinase
HB776_20995	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HB776_21030	COG1238	metal cluster binding
HB776_21035	COG0140	phosphoribosyl-ATP diphosphatase activity
HB776_21050	COG1132	(ABC) transporter
HB776_21055	COG1686	Belongs to the peptidase S11 family
HB776_21060	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_21080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HB776_21085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HB776_21105	COG2824	Alkylphosphonate utilization operon protein PhnA
HB776_21110	COG3047	cAMP biosynthetic process
HB776_21135	COG2358	TRAP transporter, solute receptor (TAXI family
HB776_21150	COG2358	TRAP transporter, solute receptor (TAXI family
HB776_21175	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HB776_21185	COG0494	nUDIX hydrolase
HB776_21195	COG1040	competence protein
HB776_21200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HB776_21215	COG2766	serine protein kinase
HB776_21220	COG2718	Belongs to the UPF0229 family
HB776_21225	COG2719	SpoVR family
HB776_21240	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_21255	COG1846	Transcriptional regulator
HB776_21260	COG1764	response to oxidative stress
HB776_21315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB776_21325	COG0527	aspartate kinase activity
HB776_21335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HB776_21340	COG2890	protein-(glutamine-N5) methyltransferase activity
HB776_21395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB776_21470	COG5001	Diguanylate cyclase
HB776_21500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HB776_21525	COG1960	acyl-CoA dehydrogenase activity
HB776_21530	COG1024	Enoyl-CoA hydratase
HB776_21545	COG1024	Enoyl-CoA hydratase
HB776_21570	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HB776_21650	COG2207	Transcriptional regulator
HB776_21655	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_21660	COG4251	negative regulation of phosphorylation
HB776_21660	COG3706	GGDEF domain
HB776_21660	COG5001	Diguanylate cyclase
HB776_21660	COG2203	Gaf domain
HB776_21665	COG5001	Diguanylate cyclase
HB776_21695	COG0825	malonyl-CoA metabolic process
HB776_21700	COG4977	sequence-specific DNA binding
HB776_21705	COG4221	oxidoreductase activity
HB776_21710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB776_21715	COG0653	protein targeting
HB776_21720	COG1285	pathogenesis
HB776_21725	COG3034	peptidoglycan biosynthetic process
HB776_21745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HB776_21750	COG3383	formate dehydrogenase (NAD+) activity
HB776_21765	COG0583	DNA-binding transcription factor activity
HB776_21815	COG0559	Belongs to the binding-protein-dependent transport system permease family
HB776_21840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB776_21885	COG2010	Cytochrome c
HB776_21900	COG3278	Belongs to the heme-copper respiratory oxidase family
HB776_21905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB776_21910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HB776_21915	COG2271	Major facilitator Superfamily
HB776_21945	COG0326	Molecular chaperone. Has ATPase activity
HB776_21965	COG0840	transmembrane signaling receptor activity
HB776_21980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB776_21990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_21995	COG0129	dihydroxy-acid dehydratase activity
HB776_22000	COG3246	L-lysine catabolic process to acetate
HB776_22015	COG0514	ATP-dependent DNA helicase (RecQ)
HB776_22040	COG0583	DNA-binding transcription factor activity
HB776_22050	COG0601	transmembrane transport
HB776_22110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB776_22110	COG2111	Na H antiporter
HB776_22115	COG0651	ATP synthesis coupled electron transport
HB776_22120	COG1006	Multisubunit Na H antiporter MnhC subunit
HB776_22125	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB776_22125	COG2111	Na H antiporter
HB776_22130	COG1320	monovalent cation:proton antiporter activity
HB776_22155	COG2235	arginine
HB776_22180	COG2197	response regulator
HB776_22190	COG0628	permease
HB776_22230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB776_22260	COG2188	Transcriptional regulator
HB776_22265	COG2084	Dehydrogenase
HB776_22290	COG0745	RESPONSE REGULATOR receiver
HB776_22295	COG1181	Belongs to the D-alanine--D-alanine ligase family
HB776_22315	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_22350	COG0596	Alpha beta hydrolase
HB776_22355	COG0662	Cupin 2, conserved barrel domain protein
HB776_22365	COG4221	oxidoreductase activity
HB776_22385	COG2226	methyltransferase
HB776_22410	COG1475	DNA binding
HB776_22440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HB776_22460	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HB776_22465	COG1877	trehalose-phosphatase activity
HB776_22470	COG2271	Major facilitator Superfamily
HB776_22495	COG4172	Belongs to the ABC transporter superfamily
HB776_22500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_22505	COG0601	transmembrane transport
HB776_22525	COG0848	biopolymer transport protein
HB776_22535	COG1653	transport
HB776_22545	COG3437	response regulator, receiver
HB776_22545	COG0784	Response regulator, receiver
HB776_22560	COG1271	oxidase subunit
HB776_22565	COG1294	oxidase, subunit
HB776_22580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB776_22585	COG1960	acyl-CoA dehydrogenase activity
HB776_22590	COG1960	acyl-CoA dehydrogenase activity
HB776_22600	COG2514	catechol 2,3-dioxygenase activity
HB776_22610	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HB776_22625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB776_22700	COG0501	Belongs to the peptidase M48B family
HB776_22725	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_22745	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
HB776_22750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_22760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB776_22765	COG1116	anion transmembrane transporter activity
HB776_22770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_22775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_22780	COG5001	Diguanylate cyclase
HB776_22805	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HB776_22815	COG2226	methyltransferase
HB776_22870	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HB776_22885	COG5443	negative regulation of bacterial-type flagellum assembly
HB776_22905	COG1749	Flagellar hook protein flgE
HB776_22910	COG0741	lytic transglycosylase activity
HB776_22945	COG1338	Plays a role in the flagellum-specific transport system
HB776_22955	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HB776_22965	COG1706	bacterial-type flagellum-dependent cell motility
HB776_22975	COG4786	Flagellar basal body rod
HB776_22980	COG1677	Flagellar hook-basal body complex protein FliE
HB776_22985	COG1558	bacterial-type flagellum-dependent cell motility
HB776_22990	COG1815	bacterial-type flagellum-dependent cell motility
HB776_22995	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HB776_23000	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HB776_23005	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HB776_23020	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HB776_23030	COG4786	Flagellar basal body rod
HB776_23035	COG1157	protein secretion by the type III secretion system
HB776_23040	COG2986	histidine ammonia-lyase
HB776_23060	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_23085	COG0412	Dienelactone hydrolase
HB776_23100	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HB776_23110	COG0268	Binds directly to 16S ribosomal RNA
HB776_23115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HB776_23125	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HB776_23150	COG1024	Enoyl-CoA hydratase
HB776_23155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_23165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB776_23175	COG1116	anion transmembrane transporter activity
HB776_23190	COG0402	S-adenosylhomocysteine deaminase activity
HB776_23195	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HB776_23205	COG3346	SURF1 family
HB776_23210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HB776_23215	COG1845	cytochrome c oxidase, subunit III
HB776_23220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB776_23225	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB776_23230	COG0477	Major facilitator Superfamily
HB776_23270	COG3278	Belongs to the heme-copper respiratory oxidase family
HB776_23310	COG0583	DNA-binding transcription factor activity
HB776_23320	COG1741	Belongs to the pirin family
HB776_23325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HB776_23370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB776_23380	COG0180	Tryptophanyl-tRNA synthetase
HB776_23415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB776_23420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HB776_23430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HB776_23435	COG1253	flavin adenine dinucleotide binding
HB776_23440	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HB776_23445	COG1396	sequence-specific DNA binding
HB776_23450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HB776_23475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HB776_23485	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HB776_23495	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HB776_23510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HB776_23520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HB776_23525	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HB776_23530	COG4133	protoheme IX ABC transporter activity
HB776_23535	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HB776_23555	COG0670	Belongs to the BI1 family
HB776_23560	COG0577	efflux transmembrane transporter activity
HB776_23560	COG1136	(ABC) transporter
HB776_23565	COG4181	ATPase activity
HB776_23575	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HB776_23580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HB776_23590	COG0045	succinate-CoA ligase (ADP-forming) activity
HB776_23595	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HB776_23615	COG1309	transcriptional regulator
HB776_23625	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB776_23630	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_23635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB776_23645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB776_23655	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HB776_23670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HB776_23680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HB776_23685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HB776_23690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HB776_23695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HB776_23700	COG0494	nUDIX hydrolase
HB776_23705	COG1051	belongs to the nudix hydrolase family
HB776_23715	COG0793	Belongs to the peptidase S41A family
HB776_23725	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HB776_23730	COG0799	negative regulation of ribosome biogenesis
HB776_23735	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HB776_23740	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HB776_23745	COG0583	DNA-binding transcription factor activity
HB776_23755	COG1335	isochorismatase
HB776_23760	COG0251	oxidation-reduction process
HB776_23765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_23770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB776_23775	COG1116	anion transmembrane transporter activity
HB776_23800	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HB776_23805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HB776_23820	COG2264	protein methyltransferase activity
HB776_23830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB776_23840	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_23865	COG0138	bifunctional purine biosynthesis protein purh
HB776_23875	COG0405	Gamma-glutamyltransferase
HB776_23880	COG2814	Major facilitator Superfamily
HB776_23900	COG0534	Mate efflux family protein
HB776_23915	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HB776_23940	COG3118	belongs to the thioredoxin family
HB776_23950	COG2835	tetraacyldisaccharide 4'-kinase activity
HB776_23975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB776_23980	COG1946	Acyl-CoA thioesterase
HB776_23985	COG0347	Belongs to the P(II) protein family
HB776_23990	COG0347	Belongs to the P(II) protein family
HB776_23995	COG0004	ammonium transporteR
HB776_24000	COG0436	Aminotransferase
HB776_24005	COG1674	ftsk spoiiie
HB776_24010	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HB776_24025	COG0745	RESPONSE REGULATOR receiver
HB776_24035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HB776_24045	COG0495	leucyl-tRNA aminoacylation
HB776_24070	COG0357	Ribosomal RNA small subunit methyltransferase G
HB776_24085	COG0445	tRNA wobble uridine modification
HB776_24090	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HB776_24095	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HB776_24100	COG1981	membrane
HB776_24105	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HB776_24110	COG0424	maF-like protein
HB776_24115	COG0237	dephospho-CoA kinase activity
HB776_24135	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HB776_24155	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HB776_24160	COG0131	Imidazoleglycerol-phosphate dehydratase
HB776_24170	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HB776_24175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HB776_24185	COG0140	phosphoribosyl-ATP diphosphatase activity
HB776_24190	COG1072	(Pantothenic acid kinase))
HB776_24200	COG5002	protein histidine kinase activity
HB776_24200	COG2205	protein histidine kinase activity
HB776_24200	COG0784	Response regulator, receiver
HB776_24215	COG3447	MASE1 domain protein
HB776_24215	COG5001	Diguanylate cyclase
HB776_24215	COG5002	protein histidine kinase activity
HB776_24235	COG0792	nuclease activity
HB776_24240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HB776_24250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HB776_24255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HB776_24260	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HB776_24265	COG1420	regulation of RNA biosynthetic process
HB776_24270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HB776_24275	COG1335	isochorismatase
HB776_24285	COG0443	Heat shock 70 kDa protein
HB776_24290	COG0484	heat shock protein binding
HB776_24295	COG3963	phosphatidate phosphatase activity
HB776_24300	COG0431	NADPH-dependent FMN reductase
HB776_24305	COG0284	orotidine-5'-phosphate decarboxylase activity
HB776_24315	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HB776_24320	COG0588	phosphoglycerate mutase activity
HB776_24330	COG1802	Transcriptional regulator
HB776_24335	COG1012	belongs to the aldehyde dehydrogenase family
HB776_24340	COG2814	Major facilitator Superfamily
HB776_24345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB776_24355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HB776_24370	COG1175	transmembrane transport
HB776_24390	COG1234	tRNA 3'-trailer cleavage
HB776_24400	COG0072	phenylalanine-tRNA ligase activity
HB776_24400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB776_24405	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HB776_24410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HB776_24415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HB776_24440	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HB776_24450	COG1968	undecaprenyl-diphosphatase activity
HB776_24465	COG4974	Belongs to the 'phage' integrase family
HB776_24475	COG1476	TRANSCRIPTIONal
HB776_24515	COG0800	Aldolase
HB776_24520	COG3734	2-keto-3-deoxy-galactonokinase
HB776_24540	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HB776_24545	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HB776_24550	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HB776_24555	COG2205	protein histidine kinase activity
HB776_24570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB776_24575	COG2368	4-hydroxyphenylacetate
HB776_24600	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HB776_24605	COG1137	ATPase activity
HB776_24610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HB776_24615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HB776_24620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB776_24640	COG0071	Belongs to the small heat shock protein (HSP20) family
HB776_24645	COG3842	ATPase activity
HB776_24650	COG0395	ABC-type sugar transport system, permease component
HB776_24655	COG1175	transmembrane transport
HB776_24660	COG1653	transport
HB776_24665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_24670	COG1764	response to oxidative stress
HB776_24675	COG1846	Transcriptional regulator
HB776_24695	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HB776_24700	COG0539	negative regulation of cytoplasmic translation
HB776_24705	COG0616	signal peptide processing
HB776_24710	COG0776	regulation of translation
HB776_24720	COG0135	phosphoribosylanthranilate isomerase activity
HB776_24725	COG0133	tryptophan synthase activity
HB776_24730	COG0159	tryptophan synthase activity
HB776_24735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HB776_24740	COG0285	dihydrofolate synthase activity
HB776_24755	COG1074	ATP-dependent DNA helicase activity
HB776_24775	COG3178	'Phosphotransferase
HB776_24780	COG2205	protein histidine kinase activity
HB776_24785	COG0756	dUTP diphosphatase activity
HB776_24790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HB776_24795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HB776_24800	COG2226	methyltransferase
HB776_24805	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HB776_24815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_24820	COG2226	methyltransferase
HB776_24830	COG1487	ribonuclease activity
HB776_24845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HB776_24850	COG0667	Aldo Keto reductase
HB776_24865	COG0779	Required for maturation of 30S ribosomal subunits
HB776_24880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HB776_24885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HB776_24890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HB776_24895	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HB776_24905	COG1185	polyribonucleotide nucleotidyltransferase activity
HB776_24915	COG2917	probably involved in intracellular septation
HB776_24920	COG0552	protein localization to endoplasmic reticulum
HB776_24925	COG0564	pseudouridine synthase activity
HB776_24930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HB776_24950	COG2910	NAD(P)H-binding
HB776_24960	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HB776_24965	COG0228	four-way junction DNA binding
HB776_24975	COG0702	epimerase
HB776_24985	COG0335	large ribosomal subunit rRNA binding
HB776_24995	COG3214	Protein conserved in bacteria
HB776_25025	COG0066	3-isopropylmalate dehydratase activity
HB776_25035	COG2301	Belongs to the HpcH HpaI aldolase family
HB776_25040	COG0288	reversible hydration of carbon dioxide
HB776_25045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HB776_25060	COG0473	3-isopropylmalate dehydrogenase activity
HB776_25065	COG0477	Major facilitator Superfamily
HB776_25070	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HB776_25075	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HB776_25080	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HB776_25085	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_25095	COG0730	response to heat
HB776_25120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_25130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_25140	COG4178	(ABC) transporter
HB776_25165	COG1785	Belongs to the alkaline phosphatase family
HB776_25170	COG1309	transcriptional regulator
HB776_25180	COG0137	argininosuccinate synthase activity
HB776_25185	COG0671	phosphoesterase, PA-phosphatase related
HB776_25195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HB776_25205	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_25220	COG2154	pterin-4-alpha-carbinolamine dehydratase
HB776_25235	COG4774	siderophore transport
HB776_25245	COG1217	gtp-binding protein TYPA
HB776_25250	COG0625	glutathione transferase activity
HB776_25260	COG3011	Protein conserved in bacteria
HB776_25270	COG1247	-acetyltransferase
HB776_25275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HB776_25280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB776_25285	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HB776_25290	COG1872	DUF167
HB776_25305	COG4221	oxidoreductase activity
HB776_25335	COG2814	Major facilitator Superfamily
HB776_25345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HB776_25350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HB776_25365	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HB776_25370	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HB776_25375	COG4948	Mandelate Racemase Muconate Lactonizing
HB776_25380	COG0583	DNA-binding transcription factor activity
HB776_25450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_25460	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB776_25460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HB776_25470	COG1760	l-serine dehydratase
HB776_25475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HB776_25500	COG0411	ABC transporter
HB776_25530	COG1595	DNA-templated transcription, initiation
HB776_25535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HB776_25540	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HB776_25555	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HB776_25560	COG1749	Flagellar hook protein flgE
HB776_25590	COG2197	response regulator
HB776_25595	COG2197	response regulator
HB776_25600	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HB776_25605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HB776_25610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HB776_25615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB776_25625	COG1596	polysaccharide export
HB776_25635	COG0438	transferase activity, transferring glycosyl groups
HB776_25650	COG2894	cell division
HB776_25735	COG1172	Belongs to the binding-protein-dependent transport system permease family
HB776_25770	COG4566	intracellular signal transduction
HB776_25775	COG4566	intracellular signal transduction
HB776_25780	COG4191	Histidine kinase
HB776_25815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HB776_25830	COG0402	S-adenosylhomocysteine deaminase activity
HB776_25845	COG0488	(ABC) transporter
HB776_25850	COG1522	sequence-specific DNA binding
HB776_25855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB776_25860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_25875	COG0243	molybdopterin cofactor binding
HB776_25880	COG0243	molybdopterin cofactor binding
HB776_25890	COG1902	pentaerythritol trinitrate reductase activity
HB776_25895	COG0243	molybdopterin cofactor binding
HB776_25955	COG0025	NhaP-type Na H and K H
HB776_25960	COG0438	transferase activity, transferring glycosyl groups
HB776_25970	COG1132	(ABC) transporter
HB776_25990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HB776_26065	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HB776_26070	COG3813	Protein conserved in bacteria
HB776_26075	COG1522	sequence-specific DNA binding
HB776_26085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB776_26110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB776_26130	COG1335	isochorismatase
HB776_26140	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HB776_26140	COG0517	IMP dehydrogenase activity
HB776_26140	COG0617	tRNA 3'-terminal CCA addition
HB776_26165	COG5002	protein histidine kinase activity
HB776_26170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HB776_26175	COG0573	inorganic phosphate transmembrane transporter activity
HB776_26180	COG0581	inorganic phosphate transmembrane transporter activity
HB776_26185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB776_26190	COG0704	Plays a role in the regulation of phosphate uptake
HB776_26195	COG0745	RESPONSE REGULATOR receiver
HB776_26205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB776_26210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HB776_26255	COG0717	Belongs to the dCTP deaminase family
HB776_26270	COG0667	Aldo Keto reductase
HB776_26280	COG2721	sulfolactate sulfo-lyase activity
HB776_26325	COG0598	Magnesium transport protein CorA
HB776_26345	COG1999	signal sequence binding
HB776_26360	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HB776_26380	COG0167	dihydroorotate dehydrogenase activity
HB776_26385	COG0534	Mate efflux family protein
HB776_26395	COG1793	dna ligase
HB776_26410	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HB776_26430	COG1201	RNA secondary structure unwinding
HB776_26445	COG0583	DNA-binding transcription factor activity
HB776_26470	COG0730	response to heat
HB776_26495	COG1960	acyl-CoA dehydrogenase activity
HB776_26500	COG0183	Belongs to the thiolase family
HB776_26505	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB776_26505	COG1024	Enoyl-CoA hydratase
HB776_26550	COG0681	Belongs to the peptidase S26 family
HB776_26555	COG0312	modulator of DNA gyrase
HB776_26565	COG1733	regulation of RNA biosynthetic process
HB776_26590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB776_26595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB776_26600	COG0109	protoheme IX farnesyltransferase activity
HB776_26610	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HB776_26625	COG3346	SURF1 family
HB776_26635	COG0612	Peptidase, M16
HB776_26640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HB776_26650	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HB776_26665	COG0356	it plays a direct role in the translocation of protons across the membrane
HB776_26695	COG0432	Pfam Uncharacterised protein family UPF0047
HB776_26710	COG2198	Histidine kinase
HB776_26710	COG2205	protein histidine kinase activity
HB776_26710	COG0784	Response regulator, receiver
HB776_26720	COG0156	8-amino-7-oxononanoate synthase activity
HB776_26730	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HB776_26750	COG0129	dihydroxy-acid dehydratase activity
HB776_26755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB776_26770	COG2176	DNA-directed DNA polymerase activity
HB776_26780	COG0183	Belongs to the thiolase family
HB776_26785	COG0402	S-adenosylhomocysteine deaminase activity
HB776_26805	COG1132	(ABC) transporter
HB776_26815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB776_26830	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HB776_26835	COG1228	amidohydrolase
HB776_26840	COG0402	S-adenosylhomocysteine deaminase activity
HB776_26870	COG2202	Pas domain
HB776_26870	COG2200	EAL domain
HB776_26870	COG2199	diguanylate cyclase activity
HB776_26875	COG0784	Response regulator, receiver
HB776_26875	COG4191	Histidine kinase
HB776_26880	COG0784	Response regulator, receiver
HB776_26880	COG4191	Histidine kinase
HB776_26890	COG2130	NADP-dependent
HB776_26895	COG1301	dicarboxylic acid transport
HB776_26905	COG0285	dihydrofolate synthase activity
HB776_26910	COG2918	glutathione biosynthetic process
HB776_26910	COG1181	Belongs to the D-alanine--D-alanine ligase family
HB776_26920	COG0069	glutamate synthase activity
HB776_26950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_26955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB776_26970	COG2003	Belongs to the UPF0758 family
HB776_26975	COG0024	Methionine aminopeptidase
HB776_26980	COG1489	DNA binding
HB776_26985	COG3264	Mechanosensitive ion channel
HB776_26985	COG1511	domain protein
HB776_26995	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HB776_27000	COG4149	molybdate abc transporter
HB776_27015	COG3585	molybdate ion transport
HB776_27020	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HB776_27025	COG5001	Diguanylate cyclase
HB776_27035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB776_27045	COG0583	DNA-binding transcription factor activity
HB776_27055	COG0640	Transcriptional regulator
HB776_27060	COG1393	Belongs to the ArsC family
HB776_27065	COG0798	PFAM Bile acid sodium symporter
HB776_27085	COG0481	GTPase activity
HB776_27095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB776_27100	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB776_27100	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HB776_27105	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HB776_27110	COG2205	protein histidine kinase activity
HB776_27115	COG0745	RESPONSE REGULATOR receiver
HB776_27125	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HB776_27135	COG0058	SHG alpha-glucan phosphorylase activity
HB776_27155	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HB776_27160	COG0625	glutathione transferase activity
HB776_27165	COG1280	lysine exporter protein (LysE YggA)
HB776_27175	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HB776_27175	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HB776_27190	COG1643	Atp-dependent helicase
HB776_27195	COG3577	Aspartyl protease
HB776_27200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB776_27205	COG0583	DNA-binding transcription factor activity
HB776_27210	COG2855	membrane
HB776_27215	COG1522	sequence-specific DNA binding
HB776_27240	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HB776_27245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HB776_27250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HB776_27260	COG2223	nitrite transmembrane transporter activity
HB776_27275	COG0242	peptide deformylase activity
HB776_27280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HB776_27285	COG0101	tRNA pseudouridine synthase activity
HB776_27290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HB776_27295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB776_27305	COG2171	N-acyltransferase activity
HB776_27320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HB776_27330	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HB776_27335	COG0706	membrane insertase activity
HB776_27345	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HB776_27350	COG3852	Histidine kinase
HB776_27360	COG2902	Dehydrogenase
HB776_27370	COG3181	Tripartite tricarboxylate transporter family receptor
HB776_27375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB776_27380	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB776_27385	COG3971	2-oxopent-4-enoate hydratase activity
HB776_27390	COG0251	oxidation-reduction process
HB776_27405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB776_27410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB776_27440	COG0330	HflC and HflK could
HB776_27465	COG1473	amidohydrolase
HB776_27480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HB776_27480	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HB776_27485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HB776_27490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB776_27515	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HB776_27520	COG0235	Class ii aldolase
HB776_27525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB776_27535	COG2814	Major facilitator Superfamily
HB776_27600	COG3300	MHYT domain
HB776_27600	COG5001	Diguanylate cyclase
HB776_27615	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HB776_27620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB776_27645	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HB776_27655	COG0735	belongs to the Fur family
HB776_27675	COG1566	PFAM secretion protein HlyD family protein
HB776_27680	COG2814	Major facilitator Superfamily
HB776_27685	COG3485	protocatechuate 3,4-dioxygenase
HB776_27690	COG3485	protocatechuate 3,4-dioxygenase
HB776_27695	COG0183	Belongs to the thiolase family
HB776_27700	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HB776_27720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_27730	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HB776_27740	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HB776_27760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB776_27775	COG4974	Belongs to the 'phage' integrase family
HB776_27790	COG1309	transcriptional regulator
HB776_27800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HB776_27805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HB776_27810	COG1253	flavin adenine dinucleotide binding
HB776_27845	COG0683	leucine binding
HB776_27855	COG0402	S-adenosylhomocysteine deaminase activity
HB776_27860	COG0154	amidase activity
HB776_27865	COG2183	response to ionizing radiation
HB776_27870	COG0443	Heat shock 70 kDa protein
HB776_27915	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB776_27915	COG1024	Enoyl-CoA hydratase
HB776_27920	COG1607	acyl-coa hydrolase
HB776_27940	COG3842	ATPase activity
HB776_27945	COG3842	ATPase activity
HB776_27955	COG0395	ABC-type sugar transport system, permease component
HB776_27970	COG1902	pentaerythritol trinitrate reductase activity
HB776_28010	COG1051	belongs to the nudix hydrolase family
HB776_28060	COG0714	Associated with various cellular activities
HB776_28080	COG0617	tRNA 3'-terminal CCA addition
HB776_28120	COG0602	queuosine metabolic process
HB776_28135	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HB776_28145	COG4774	siderophore transport
HB776_28150	COG4774	siderophore transport
HB776_28160	COG0723	plastoquinol--plastocyanin reductase activity
HB776_28165	COG2857	Cytochrome c1
HB776_28165	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HB776_28170	COG0385	Bile acid
HB776_28175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB776_28205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HB776_28235	COG1566	PFAM secretion protein HlyD family protein
HB776_28260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB776_28270	COG0438	transferase activity, transferring glycosyl groups
HB776_28275	COG0583	DNA-binding transcription factor activity
HB776_28280	COG1741	Belongs to the pirin family
HB776_28285	COG0655	NAD(P)H dehydrogenase (quinone) activity
HB776_28295	COG2005	Transcriptional regulator
HB776_28295	COG3585	molybdate ion transport
HB776_28300	COG1618	nucleotide phosphatase activity, acting on free nucleotides
HB776_28300	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HB776_28305	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HB776_28310	COG0477	Major facilitator Superfamily
HB776_28325	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_28330	COG2207	Transcriptional regulator
HB776_28330	COG0662	Cupin 2, conserved barrel domain protein
HB776_28350	COG0604	alcohol dehydrogenase
HB776_28355	COG0142	geranyltranstransferase activity
HB776_28365	COG2890	protein-(glutamine-N5) methyltransferase activity
HB776_28380	COG0752	glycyl-tRNA synthetase alpha subunit
HB776_28385	COG0751	glycine-tRNA ligase activity
HB776_28405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HB776_28405	COG0574	Belongs to the PEP-utilizing enzyme family
HB776_28425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HB776_28430	COG0604	alcohol dehydrogenase
HB776_28440	COG0501	Belongs to the peptidase M48B family
HB776_28445	COG1704	LemA family
HB776_28470	COG1196	nuclear chromosome segregation
HB776_28490	COG2076	Multidrug Resistance protein
HB776_28495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB776_28495	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HB776_28505	COG1194	a g-specific adenine glycosylase
HB776_28515	COG0840	transmembrane signaling receptor activity
HB776_28540	COG0625	glutathione transferase activity
HB776_28545	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HB776_28550	COG2321	neutral zinc metallopeptidase
HB776_28555	COG0521	Mo-molybdopterin cofactor biosynthetic process
HB776_28580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HB776_28590	COG1573	uracil-dna glycosylase
HB776_28605	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HB776_28610	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_28615	COG0473	3-isopropylmalate dehydrogenase activity
HB776_28620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HB776_28635	COG4336	lyase activity
HB776_28675	COG0235	Class ii aldolase
HB776_28680	COG2084	Dehydrogenase
HB776_28685	COG3622	Belongs to the hyi family
HB776_28690	COG3395	kinase activity
HB776_28695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB776_28700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB776_28715	COG2070	2-Nitropropane dioxygenase
HB776_28720	COG2072	flavoprotein involved in K transport
HB776_28730	COG1024	Enoyl-CoA hydratase
HB776_28745	COG1024	Enoyl-CoA hydratase
HB776_28775	COG2135	peptidase activity
HB776_28780	COG0456	acetyltransferase
HB776_28785	COG0277	FAD linked oxidase domain protein
HB776_28790	COG0009	L-threonylcarbamoyladenylate synthase
HB776_28800	COG2186	Transcriptional regulator
HB776_28815	COG3842	ATPase activity
HB776_28825	COG0395	ABC-type sugar transport system, permease component
HB776_28835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HB776_28845	COG0392	lysyltransferase activity
HB776_28845	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HB776_28880	COG0683	leucine binding
HB776_28885	COG0346	lactoylglutathione lyase activity
HB776_28900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HB776_28905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB776_28935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB776_28955	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB776_28955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HB776_28965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB776_28970	COG0656	L-ascorbic acid biosynthetic process
HB776_28975	COG0864	Transcriptional regulator
HB776_28980	COG4774	siderophore transport
HB776_28985	COG2706	6-phosphogluconolactonase activity
HB776_28995	COG1960	acyl-CoA dehydrogenase activity
HB776_29000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB776_29000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB776_29005	COG0475	glutathione-regulated potassium exporter activity
HB776_29005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB776_29010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB776_29020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB776_29030	COG1280	lysine exporter protein (LysE YggA)
HB776_29055	COG2814	Major facilitator Superfamily
HB776_29070	COG3253	May function as heme-dependent peroxidase
HB776_29085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HB776_29100	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HB776_29120	COG2951	lytic endotransglycosylase activity
HB776_29150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HB776_29155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HB776_29185	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HB776_29195	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HB776_29200	COG1766	The M ring may be actively involved in energy transduction
HB776_29210	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HB776_29220	COG0482	sulfurtransferase activity
HB776_29235	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HB776_29235	COG1082	Xylose isomerase domain protein TIM barrel
HB776_29250	COG4177	L-phenylalanine transmembrane transporter activity
HB776_29265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HB776_29270	COG0583	DNA-binding transcription factor activity
HB776_29275	COG0438	transferase activity, transferring glycosyl groups
HB776_29295	COG0405	Gamma-glutamyltransferase
HB776_29300	COG2199	diguanylate cyclase activity
HB776_29305	COG0523	cobalamin synthesis protein
HB776_29310	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HB776_29315	COG3454	Phosphonate metabolism
HB776_29325	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HB776_29335	COG3639	organic phosphonate transmembrane transporter activity
HB776_29340	COG3639	organic phosphonate transmembrane transporter activity
HB776_29345	COG0625	glutathione transferase activity
HB776_29355	COG3795	YCII-related domain
HB776_29360	COG4941	Belongs to the sigma-70 factor family
HB776_29375	COG2814	Major facilitator Superfamily
HB776_29385	COG4774	siderophore transport
HB776_29390	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_29415	COG1335	isochorismatase
HB776_29420	COG0583	DNA-binding transcription factor activity
HB776_29430	COG3795	YCII-related domain
HB776_29435	COG1309	transcriptional regulator
HB776_29450	COG0848	biopolymer transport protein
HB776_29460	COG0823	Involved in the tonB-independent uptake of proteins
HB776_29465	COG5001	Diguanylate cyclase
HB776_29475	COG2885	chlorophyll binding
HB776_29490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB776_29515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB776_29515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HB776_29520	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB776_29535	COG1309	transcriptional regulator
HB776_29540	COG3474	cytochrome
HB776_29545	COG0277	FAD linked oxidase domain protein
HB776_29550	COG0277	FAD linked oxidase domain protein
HB776_29555	COG0247	lactate metabolic process
HB776_29575	COG4178	(ABC) transporter
HB776_29580	COG1620	l-lactate permease
HB776_29595	COG0459	protein refolding
HB776_29600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HB776_29620	COG1388	LysM domain
HB776_29620	COG1376	ErfK ybiS ycfS ynhG family protein
HB776_29625	COG3416	Protein conserved in bacteria
HB776_29650	COG0463	Glycosyl transferase, family 2
HB776_29655	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HB776_29660	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HB776_29680	COG0583	DNA-binding transcription factor activity
HB776_29690	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
HB776_29690	COG0028	Belongs to the TPP enzyme family
HB776_29700	COG0277	FAD linked oxidase domain protein
HB776_29710	COG0312	modulator of DNA gyrase
HB776_29715	COG0483	inositol monophosphate 1-phosphatase activity
HB776_29730	COG1519	Transferase
HB776_29735	COG1663	tetraacyldisaccharide 4'-kinase activity
HB776_29745	COG1570	exodeoxyribonuclease VII activity
HB776_29770	COG0151	Belongs to the GarS family
HB776_29780	COG0590	tRNA wobble adenosine to inosine editing
HB776_29785	COG1187	pseudouridine synthase activity
HB776_29790	COG0742	ribosomal rna small subunit methyltransferase
HB776_29800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HB776_29815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HB776_29820	COG0612	Peptidase, M16
HB776_29825	COG0612	Peptidase, M16
HB776_29835	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HB776_29840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HB776_29850	COG0196	riboflavin kinase activity
HB776_29855	COG0745	RESPONSE REGULATOR receiver
HB776_29880	COG0124	histidyl-tRNA synthetase
HB776_29885	COG1942	4-Oxalocrotonate Tautomerase
HB776_29915	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HB776_29920	COG1278	Cold shock
HB776_29930	COG0322	excinuclease ABC activity
HB776_29935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HB776_29945	COG0314	molybdopterin synthase activity
HB776_29950	COG2890	protein-(glutamine-N5) methyltransferase activity
HB776_29960	COG0534	Mate efflux family protein
HB776_29970	COG1846	Transcriptional regulator
HB776_29975	COG0745	RESPONSE REGULATOR receiver
HB776_29985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HB776_29990	COG0456	acetyltransferase
HB776_30000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HB776_30005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB776_30035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HB776_30040	COG0193	aminoacyl-tRNA hydrolase activity
HB776_30045	COG0012	GTP binding
HB776_30055	COG2030	dehydratase
HB776_30105	COG1301	dicarboxylic acid transport
HB776_30110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB776_30130	COG0556	nucleotide-excision repair
HB776_30140	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HB776_30165	COG1999	signal sequence binding
HB776_30175	COG0625	glutathione transferase activity
HB776_30185	COG3706	GGDEF domain
HB776_30205	COG0667	Aldo Keto reductase
HB776_30225	COG2133	pyrroloquinoline quinone binding
HB776_30245	COG0436	Aminotransferase
HB776_30260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HB776_30275	COG0659	secondary active sulfate transmembrane transporter activity
HB776_30280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HB776_30295	COG1304	FMN binding
HB776_30305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB776_30320	COG0625	glutathione transferase activity
HB776_30330	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HB776_30335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB776_30340	COG0840	transmembrane signaling receptor activity
HB776_30350	COG0840	transmembrane signaling receptor activity
HB776_30385	COG0840	transmembrane signaling receptor activity
HB776_30385	COG3290	protein histidine kinase activity
HB776_30390	COG4774	siderophore transport
HB776_30410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HB776_30430	COG2140	Oxalate decarboxylase
HB776_30440	COG0384	phenazine biosynthesis protein PhzF
HB776_30455	COG1278	Cold shock
HB776_30465	COG0784	Response regulator, receiver
HB776_30465	COG4191	Histidine kinase
HB776_30470	COG2202	Pas domain
HB776_30470	COG3920	Histidine kinase
HB776_30485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HB776_30495	COG4774	siderophore transport
HB776_30505	COG2514	catechol 2,3-dioxygenase activity
HB776_30550	COG2207	Transcriptional regulator
HB776_30565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB776_30590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_30595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB776_30600	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_30610	COG2186	Transcriptional regulator
HB776_30625	COG4106	trans-aconitate 2-methyltransferase activity
HB776_30705	COG0318	PFAM AMP-dependent synthetase and ligase
HB776_30710	COG0183	Belongs to the thiolase family
HB776_30715	COG1960	acyl-CoA dehydrogenase activity
HB776_30725	COG1028	Short-chain dehydrogenase reductase Sdr
HB776_30730	COG0445	tRNA wobble uridine modification
HB776_30735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HB776_30755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB776_30765	COG3795	YCII-related domain
HB776_30770	COG1605	Chorismate mutase
HB776_30770	COG0077	Prephenate dehydratase
HB776_30775	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HB776_30780	COG3474	cytochrome
HB776_30785	COG4166	transmembrane transport
HB776_30790	COG4166	transmembrane transport
HB776_30795	COG4174	ABC transporter (Permease)
HB776_30800	COG4239	(ABC) transporter, permease
HB776_30805	COG4172	Belongs to the ABC transporter superfamily
HB776_30820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HB776_30855	COG4964	Belongs to the GSP D family
HB776_30895	COG1278	Cold shock
HB776_30900	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HB776_30905	COG0513	Belongs to the DEAD box helicase family
HB776_30925	COG1129	ABC transporter
HB776_30935	COG0829	nickel cation binding
HB776_30940	COG0831	urea catabolic process
HB776_30945	COG0832	Belongs to the urease beta subunit family
HB776_30960	COG0804	urea catabolic process
HB776_30970	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HB776_30975	COG0830	nickel cation binding
HB776_30990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HB776_31075	COG0454	-acetyltransferase
HB776_31100	COG1278	Cold shock
HB776_31110	COG3293	Transposase
HB776_31115	COG5001	Diguanylate cyclase
HB776_31115	COG3300	MHYT domain
HB776_31120	COG3706	GGDEF domain
HB776_31225	COG2875	Belongs to the precorrin methyltransferase family
HB776_31235	COG0038	chloride channel
HB776_31265	COG2814	Major facilitator Superfamily
HB776_31275	COG1742	UPF0060 membrane protein
HB776_31280	COG0642	Histidine kinase
HB776_31305	COG4962	Type ii secretion system protein e
HB776_31310	COG3838	Conjugal transfer protein Trbc
HB776_31320	COG3451	type IV secretory pathway VirB4
HB776_31335	COG0477	Major facilitator Superfamily
HB776_31340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB776_31345	COG0583	DNA-binding transcription factor activity
HB776_31355	COG0477	Major facilitator Superfamily
HB776_31360	COG1942	4-Oxalocrotonate Tautomerase
HB776_31385	COG0604	alcohol dehydrogenase
HB776_31390	COG1309	transcriptional regulator
HB776_31410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB776_31415	COG0028	Belongs to the TPP enzyme family
HB776_31430	COG1396	sequence-specific DNA binding
HB776_31450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs