locus-tag	class	description
BWR18_00010	COG0556	nucleotide-excision repair
BWR18_00035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BWR18_00115	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BWR18_00175	COG0352	thiamine-phosphate diphosphorylase activity
BWR18_00180	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BWR18_00190	COG3008	intermembrane lipid transfer
BWR18_00190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BWR18_00195	COG2995	paraquat-inducible protein a
BWR18_00205	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BWR18_00210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BWR18_00225	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BWR18_00230	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BWR18_00235	COG3454	Phosphonate metabolism
BWR18_00240	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
BWR18_00250	COG4778	phosphonate C-P lyase system protein PhnL
BWR18_00255	COG4107	phosphonate C-P lyase system protein PhnK
BWR18_00265	COG3627	carbon phosphorus lyase activity
BWR18_00275	COG3626	phosphonate metabolism
BWR18_00285	COG3624	Phosphonate C-P lyase system protein PhnG
BWR18_00290	COG2188	Transcriptional regulator
BWR18_00295	COG3454	Phosphonate metabolism
BWR18_00305	COG3639	organic phosphonate transmembrane transporter activity
BWR18_00310	COG3639	organic phosphonate transmembrane transporter activity
BWR18_00315	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BWR18_00320	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BWR18_00330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BWR18_00350	COG5328	Belongs to the UPF0262 family
BWR18_00380	COG0481	GTPase activity
BWR18_00415	COG0588	phosphoglycerate mutase activity
BWR18_00420	COG0438	transferase activity, transferring glycosyl groups
BWR18_00435	COG0668	transmembrane transport
BWR18_00450	COG0601	transmembrane transport
BWR18_00470	COG1024	Enoyl-CoA hydratase
BWR18_00470	COG1250	3-hydroxyacyl-CoA dehydrogenase
BWR18_00475	COG1960	acyl-CoA dehydrogenase activity
BWR18_00480	COG1960	acyl-CoA dehydrogenase activity
BWR18_00490	COG0318	PFAM AMP-dependent synthetase and ligase
BWR18_00500	COG1070	Carbohydrate kinase
BWR18_00505	COG2115	Belongs to the xylose isomerase family
BWR18_00510	COG1858	cytochrome C peroxidase
BWR18_00525	COG4213	ABC transporter substrate-binding protein
BWR18_00530	COG4214	carbohydrate transport
BWR18_00540	COG0837	glucose binding
BWR18_00565	COG1522	sequence-specific DNA binding
BWR18_00610	COG3842	ATPase activity
BWR18_00615	COG0366	Alpha amylase catalytic
BWR18_00620	COG0395	ABC-type sugar transport system, permease component
BWR18_00625	COG1175	transmembrane transport
BWR18_00630	COG1653	transport
BWR18_00635	COG1609	Transcriptional regulator
BWR18_00640	COG2723	6-phospho-beta-galactosidase activity
BWR18_00650	COG0673	inositol 2-dehydrogenase activity
BWR18_00665	COG4989	oxidoreductase activity
BWR18_00670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BWR18_00685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR18_00705	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BWR18_00725	COG1960	acyl-CoA dehydrogenase activity
BWR18_00740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWR18_00770	COG4977	sequence-specific DNA binding
BWR18_00770	COG1917	Cupin 2, conserved barrel domain protein
BWR18_00800	COG2249	NAD(P)H dehydrogenase (quinone) activity
BWR18_00805	COG2249	NAD(P)H dehydrogenase (quinone) activity
BWR18_00815	COG0402	S-adenosylhomocysteine deaminase activity
BWR18_00820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BWR18_00840	COG3813	Protein conserved in bacteria
BWR18_00865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BWR18_00870	COG0165	Argininosuccinate lyase
BWR18_00885	COG0019	diaminopimelate decarboxylase activity
BWR18_00900	COG2884	Cell division ATP-binding protein ftsE
BWR18_00920	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BWR18_00955	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWR18_00970	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BWR18_00990	COG0045	succinate-CoA ligase (ADP-forming) activity
BWR18_01005	COG0039	L-malate dehydrogenase activity
BWR18_01025	COG2301	Belongs to the HpcH HpaI aldolase family
BWR18_01040	COG2030	dehydratase
BWR18_01100	COG0813	purine-nucleoside phosphorylase activity
BWR18_01120	COG2937	Belongs to the GPAT DAPAT family
BWR18_01145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BWR18_01155	COG0730	response to heat
BWR18_01185	COG1214	PFAM Peptidase M22, glycoprotease
BWR18_01195	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BWR18_01245	COG1272	protein, Hemolysin III
BWR18_01265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BWR18_01280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BWR18_01285	COG3524	carbohydrate:proton symporter activity
BWR18_01295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BWR18_01330	COG2943	transferase activity, transferring hexosyl groups
BWR18_01335	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BWR18_01350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BWR18_01380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BWR18_01390	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BWR18_01395	COG1643	Atp-dependent helicase
BWR18_01400	COG1703	isobutyryl-CoA mutase activity
BWR18_01405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BWR18_01420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BWR18_01430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BWR18_01435	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BWR18_01440	COG0424	maF-like protein
BWR18_01450	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BWR18_01470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BWR18_01485	COG0784	Response regulator, receiver
BWR18_01530	COG1295	ribonuclease BN
BWR18_01560	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BWR18_01585	COG0784	Response regulator, receiver
BWR18_01655	COG0569	domain protein
BWR18_01660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BWR18_01665	COG2116	formate transmembrane transporter activity
BWR18_01670	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_01675	COG0366	Alpha amylase catalytic
BWR18_01680	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_01720	COG0530	calcium, potassium:sodium antiporter activity
BWR18_01735	COG2863	cytochrome
BWR18_01750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BWR18_01825	COG0693	protein deglycase activity
BWR18_01835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BWR18_01845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BWR18_01850	COG0583	DNA-binding transcription factor activity
BWR18_01860	COG0747	negative chemotaxis
BWR18_01865	COG0601	transmembrane transport
BWR18_01870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWR18_01875	COG0444	Belongs to the ABC transporter superfamily
BWR18_01880	COG4608	Belongs to the ABC transporter superfamily
BWR18_01885	COG0747	negative chemotaxis
BWR18_01895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BWR18_01910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BWR18_01940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BWR18_01975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BWR18_01980	COG0730	response to heat
BWR18_01995	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BWR18_02000	COG4235	cytochrome complex assembly
BWR18_02005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWR18_02030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BWR18_02030	COG0446	pyridine nucleotide-disulphide oxidoreductase
BWR18_02065	COG5265	(ABC) transporter
BWR18_02095	COG1160	GTP binding
BWR18_02110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BWR18_02125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BWR18_02130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BWR18_02145	COG3737	Protein of unknown function (DUF498/DUF598)
BWR18_02150	COG4133	protoheme IX ABC transporter activity
BWR18_02155	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BWR18_02160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BWR18_02170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BWR18_02175	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_02195	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BWR18_02205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BWR18_02230	COG0644	oxidoreductase
BWR18_02240	COG0006	proline dipeptidase activity
BWR18_02285	COG1295	ribonuclease BN
BWR18_02295	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BWR18_02295	COG0321	lipoyl(octanoyl) transferase activity
BWR18_02300	COG0084	hydrolase, TatD family'
BWR18_02310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BWR18_02315	COG1686	Belongs to the peptidase S11 family
BWR18_02335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWR18_02365	COG2072	flavoprotein involved in K transport
BWR18_02380	COG2072	flavoprotein involved in K transport
BWR18_02385	COG3284	Transcriptional regulator
BWR18_02400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWR18_02410	COG3483	tryptophan 2,3-dioxygenase activity
BWR18_02425	COG0559	Belongs to the binding-protein-dependent transport system permease family
BWR18_02435	COG0411	ABC transporter
BWR18_02450	COG0740	serine-type endopeptidase activity
BWR18_02455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BWR18_02480	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BWR18_02485	COG0439	Biotin carboxylase
BWR18_02490	COG0511	ligase activity, forming carbon-carbon bonds
BWR18_02500	COG0410	ABC transporter
BWR18_02515	COG0559	Belongs to the binding-protein-dependent transport system permease family
BWR18_02525	COG1396	sequence-specific DNA binding
BWR18_02525	COG3800	Transcriptional regulator
BWR18_02530	COG0745	RESPONSE REGULATOR receiver
BWR18_02570	COG3750	Belongs to the UPF0335 family
BWR18_02590	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BWR18_02630	COG1404	Belongs to the peptidase S8 family
BWR18_02665	COG1132	(ABC) transporter
BWR18_02675	COG0559	Belongs to the binding-protein-dependent transport system permease family
BWR18_02680	COG1172	Belongs to the binding-protein-dependent transport system permease family
BWR18_02720	COG3842	ATPase activity
BWR18_02725	COG1175	transmembrane transport
BWR18_02730	COG0395	ABC-type sugar transport system, permease component
BWR18_02765	COG0395	ABC-type sugar transport system, permease component
BWR18_02810	COG4209	transmembrane transport
BWR18_02830	COG1172	Belongs to the binding-protein-dependent transport system permease family
BWR18_02845	COG1609	Transcriptional regulator
BWR18_02870	COG0673	inositol 2-dehydrogenase activity
BWR18_02885	COG3962	Belongs to the TPP enzyme family
BWR18_02895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BWR18_02910	COG0673	inositol 2-dehydrogenase activity
BWR18_02915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BWR18_02920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BWR18_02945	COG2010	Cytochrome c
BWR18_02950	COG0348	domain, Protein
BWR18_02970	COG3246	L-lysine catabolic process to acetate
BWR18_02985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BWR18_02995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BWR18_03015	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BWR18_03020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BWR18_03025	COG1999	signal sequence binding
BWR18_03050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BWR18_03055	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BWR18_03075	COG0280	phosphate acetyltransferase
BWR18_03075	COG0281	malic enzyme
BWR18_03105	COG0318	PFAM AMP-dependent synthetase and ligase
BWR18_03125	COG0667	Aldo Keto reductase
BWR18_03135	COG0662	Cupin 2, conserved barrel domain protein
BWR18_03150	COG0183	Belongs to the thiolase family
BWR18_03155	COG0435	Glutathione S-transferase
BWR18_03160	COG1960	acyl-CoA dehydrogenase activity
BWR18_03170	COG1960	acyl-CoA dehydrogenase activity
BWR18_03180	COG0589	response to stress
BWR18_03185	COG0628	permease
BWR18_03205	COG0534	Mate efflux family protein
BWR18_03210	COG0167	dihydroorotate dehydrogenase activity
BWR18_03225	COG0737	Belongs to the 5'-nucleotidase family
BWR18_03230	COG2135	peptidase activity
BWR18_03240	COG1960	acyl-CoA dehydrogenase activity
BWR18_03250	COG3842	ATPase activity
BWR18_03295	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_03325	COG2226	methyltransferase
BWR18_03345	COG4948	Mandelate Racemase Muconate Lactonizing
BWR18_03360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BWR18_03375	COG0596	Alpha beta hydrolase
BWR18_03375	COG2945	thiolester hydrolase activity
BWR18_03385	COG1047	Peptidyl-prolyl cis-trans
BWR18_03395	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BWR18_03400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BWR18_03405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BWR18_03420	COG0840	transmembrane signaling receptor activity
BWR18_03430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BWR18_03435	COG2885	chlorophyll binding
BWR18_03445	COG1702	phosphate starvation-inducible protein PhoH
BWR18_03450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BWR18_03455	COG1253	flavin adenine dinucleotide binding
BWR18_03460	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BWR18_03465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BWR18_03490	COG0539	negative regulation of cytoplasmic translation
BWR18_03495	COG0776	regulation of translation
BWR18_03505	COG0135	phosphoribosylanthranilate isomerase activity
BWR18_03515	COG0133	tryptophan synthase activity
BWR18_03540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BWR18_03550	COG0193	aminoacyl-tRNA hydrolase activity
BWR18_03555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BWR18_03560	COG0738	Major facilitator superfamily
BWR18_03580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BWR18_03585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BWR18_03600	COG0159	tryptophan synthase activity
BWR18_03610	COG0012	GTP binding
BWR18_03625	COG0154	amidase activity
BWR18_03630	COG1454	alcohol dehydrogenase
BWR18_03640	COG1959	2 iron, 2 sulfur cluster binding
BWR18_03650	COG0523	cobalamin synthesis protein
BWR18_03655	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
BWR18_03665	COG0735	belongs to the Fur family
BWR18_03670	COG1121	(ABC) transporter
BWR18_03675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BWR18_03680	COG2801	Transposase and inactivated derivatives
BWR18_03690	COG0601	transmembrane transport
BWR18_03695	COG4608	Belongs to the ABC transporter superfamily
BWR18_03700	COG0444	Belongs to the ABC transporter superfamily
BWR18_03725	COG0784	Response regulator, receiver
BWR18_03740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BWR18_03755	COG2116	formate transmembrane transporter activity
BWR18_03770	COG0395	ABC-type sugar transport system, permease component
BWR18_03780	COG3842	ATPase activity
BWR18_03785	COG3842	ATPase activity
BWR18_03795	COG1609	Transcriptional regulator
BWR18_03805	COG0673	inositol 2-dehydrogenase activity
BWR18_03815	COG1132	(ABC) transporter
BWR18_03820	COG0318	PFAM AMP-dependent synthetase and ligase
BWR18_03830	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BWR18_03855	COG4166	transmembrane transport
BWR18_03865	COG2379	hydroxypyruvate reductase
BWR18_03885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWR18_03890	COG1490	D-aminoacyl-tRNA deacylase activity
BWR18_03920	COG3853	Toxic anion resistance protein (TelA)
BWR18_03935	COG1187	pseudouridine synthase activity
BWR18_03940	COG0590	tRNA wobble adenosine to inosine editing
BWR18_03945	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BWR18_03955	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BWR18_03960	COG0154	amidase activity
BWR18_03980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BWR18_03995	COG0670	Belongs to the BI1 family
BWR18_04005	COG0583	DNA-binding transcription factor activity
BWR18_04010	COG1396	sequence-specific DNA binding
BWR18_04015	COG0483	inositol monophosphate 1-phosphatase activity
BWR18_04025	COG0402	S-adenosylhomocysteine deaminase activity
BWR18_04030	COG2239	Acts as a magnesium transporter
BWR18_04035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BWR18_04040	COG1692	metallophosphoesterase
BWR18_04050	COG0471	metal ion transport
BWR18_04050	COG3273	potassium ion transport
BWR18_04080	COG0471	metal ion transport
BWR18_04080	COG0490	domain, Protein
BWR18_04085	COG0217	transcriptional regulatory protein
BWR18_04145	COG1309	transcriptional regulator
BWR18_04150	COG3119	arylsulfatase activity
BWR18_04175	COG1396	sequence-specific DNA binding
BWR18_04175	COG3800	Transcriptional regulator
BWR18_04185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BWR18_04220	COG0439	Biotin carboxylase
BWR18_04255	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BWR18_04270	COG0248	Ppx GppA phosphatase
BWR18_04275	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BWR18_04285	COG0628	permease
BWR18_04290	COG0442	prolyl-tRNA aminoacylation
BWR18_04310	COG1136	(ABC) transporter
BWR18_04315	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BWR18_04335	COG0187	DNA topoisomerase II activity
BWR18_04365	COG0534	Mate efflux family protein
BWR18_04405	COG1846	Transcriptional regulator
BWR18_04420	COG0346	lactoylglutathione lyase activity
BWR18_04435	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
BWR18_04460	COG1278	Cold shock
BWR18_04465	COG1393	Belongs to the ArsC family
BWR18_04480	COG3220	belongs to the UPF0276 family
BWR18_04490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BWR18_04495	COG2814	Major facilitator Superfamily
BWR18_04515	COG0640	Transcriptional regulator
BWR18_04525	COG2211	Major facilitator Superfamily
BWR18_04570	COG3243	poly(R)-hydroxyalkanoic acid synthase
BWR18_04605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BWR18_04610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWR18_04615	COG0174	glutamine synthetase
BWR18_04620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BWR18_04620	COG0519	Catalyzes the synthesis of GMP from XMP
BWR18_04625	COG0174	glutamine synthetase
BWR18_04630	COG4160	amino acid transport
BWR18_04635	COG4215	(ABC) transporter
BWR18_04665	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BWR18_04685	COG0504	CTP synthase activity
BWR18_04715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BWR18_04755	COG1760	l-serine dehydratase
BWR18_04770	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BWR18_04780	COG0330	HflC and HflK could
BWR18_04785	COG0330	HflC and HflK could
BWR18_04795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BWR18_04805	COG0587	DNA-directed DNA polymerase activity
BWR18_04830	COG1570	exodeoxyribonuclease VII activity
BWR18_04840	COG3239	Fatty acid desaturase
BWR18_04855	COG0552	protein localization to endoplasmic reticulum
BWR18_04865	COG2917	probably involved in intracellular septation
BWR18_04875	COG0625	glutathione transferase activity
BWR18_04890	COG1469	GTP cyclohydrolase I activity
BWR18_04900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BWR18_04920	COG0752	glycyl-tRNA synthetase alpha subunit
BWR18_04935	COG0751	glycine-tRNA ligase activity
BWR18_04940	COG0574	Belongs to the PEP-utilizing enzyme family
BWR18_04940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BWR18_04945	COG3773	Cell wall hydrolase
BWR18_04945	COG3409	Peptidoglycan-binding domain 1 protein
BWR18_04955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BWR18_04960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BWR18_04985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BWR18_04990	COG1522	sequence-specific DNA binding
BWR18_05015	COG1802	Transcriptional regulator
BWR18_05025	COG0505	Belongs to the CarA family
BWR18_05030	COG1610	YqeY-like protein
BWR18_05065	COG0321	lipoyl(octanoyl) transferase activity
BWR18_05100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BWR18_05105	COG0784	Response regulator, receiver
BWR18_05105	COG2198	Histidine kinase
BWR18_05105	COG5002	protein histidine kinase activity
BWR18_05110	COG0544	peptidyl-prolyl cis-trans isomerase activity
BWR18_05125	COG0359	binds to the 23S rRNA
BWR18_05130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BWR18_05135	COG0360	Binds together with S18 to 16S ribosomal RNA
BWR18_05145	COG2353	YceI-like domain
BWR18_05155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BWR18_05180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BWR18_05185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BWR18_05200	COG4695	Portal protein
BWR18_05280	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWR18_05285	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWR18_05285	COG0022	dehydrogenase e1 component
BWR18_05290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BWR18_05295	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BWR18_05300	COG0300	oxidoreductase activity
BWR18_05305	COG0126	phosphoglycerate kinase activity
BWR18_05310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BWR18_05315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BWR18_05330	COG0739	heme binding
BWR18_05335	COG2833	Protein of unknown function (DUF455)
BWR18_05345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BWR18_05355	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BWR18_05370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BWR18_05410	COG1960	acyl-CoA dehydrogenase activity
BWR18_05435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BWR18_05455	COG2354	Protein conserved in bacteria
BWR18_05465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BWR18_05480	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BWR18_05495	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BWR18_05535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BWR18_05560	COG0175	sulfate reduction
BWR18_05565	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BWR18_05575	COG1648	precorrin-2 dehydrogenase activity
BWR18_05575	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BWR18_05580	COG1522	sequence-specific DNA binding
BWR18_05585	COG2124	cytochrome p450
BWR18_05600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR18_05605	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BWR18_05610	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR18_05615	COG0149	triose-phosphate isomerase activity
BWR18_05625	COG3070	regulator of competence-specific genes
BWR18_05645	COG2151	metal-sulfur cluster biosynthetic enzyme
BWR18_05655	COG0583	DNA-binding transcription factor activity
BWR18_05670	COG0343	queuine tRNA-ribosyltransferase activity
BWR18_05690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BWR18_05710	COG0406	alpha-ribazole phosphatase activity
BWR18_05730	COG1741	Belongs to the pirin family
BWR18_05770	COG0156	8-amino-7-oxononanoate synthase activity
BWR18_05780	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BWR18_05800	COG0860	N-Acetylmuramoyl-L-alanine amidase
BWR18_05805	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BWR18_05810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BWR18_05830	COG4638	Rieske (2fe-2S)
BWR18_05850	COG0028	Belongs to the TPP enzyme family
BWR18_05870	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BWR18_05880	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR18_05885	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BWR18_05955	COG0542	response to heat
BWR18_05960	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BWR18_05985	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BWR18_06040	COG4325	translation initiation factor activity
BWR18_06055	COG4536	flavin adenine dinucleotide binding
BWR18_06065	COG4974	Belongs to the 'phage' integrase family
BWR18_06080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BWR18_06085	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BWR18_06095	COG0629	single-stranded DNA binding
BWR18_06100	COG0741	lytic transglycosylase activity
BWR18_06100	COG0739	heme binding
BWR18_06100	COG1196	nuclear chromosome segregation
BWR18_06120	COG0601	transmembrane transport
BWR18_06130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BWR18_06140	COG0233	cytoplasmic translational termination
BWR18_06145	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BWR18_06150	COG0575	Belongs to the CDS family
BWR18_06155	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BWR18_06160	COG0750	zinc metalloprotease
BWR18_06165	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BWR18_06175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BWR18_06180	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWR18_06185	COG3494	Protein of unknown function (DUF1009)
BWR18_06190	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWR18_06195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BWR18_06200	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BWR18_06220	COG0148	phosphopyruvate hydratase activity
BWR18_06225	COG0697	spore germination
BWR18_06240	COG0513	Belongs to the DEAD box helicase family
BWR18_06255	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BWR18_06280	COG3956	TIGRFAM MazG family protein
BWR18_06290	COG0010	Belongs to the arginase family
BWR18_06310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BWR18_06315	COG2890	protein-(glutamine-N5) methyltransferase activity
BWR18_06325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BWR18_06330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BWR18_06335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BWR18_06355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BWR18_06370	COG2095	MarC family integral membrane protein
BWR18_06375	COG0488	(ABC) transporter
BWR18_06380	COG2814	Major facilitator Superfamily
BWR18_06385	COG0105	UTP biosynthetic process
BWR18_06405	COG2017	converts alpha-aldose to the beta-anomer
BWR18_06470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BWR18_06500	COG0326	Molecular chaperone. Has ATPase activity
BWR18_06555	COG2205	protein histidine kinase activity
BWR18_06570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BWR18_06575	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BWR18_06580	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BWR18_06590	COG2166	iron-sulfur cluster assembly
BWR18_06605	COG5012	cobalamin binding
BWR18_06615	COG0646	methionine synthase
BWR18_06615	COG1410	methionine synthase
BWR18_06630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BWR18_06635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BWR18_06640	COG0047	phosphoribosylformylglycinamidine synthase activity
BWR18_06650	COG2204	response regulator
BWR18_06655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BWR18_06670	COG1530	ribonuclease E activity
BWR18_06675	COG0425	Belongs to the sulfur carrier protein TusA family
BWR18_06680	COG0785	Cytochrome C biogenesis protein
BWR18_06690	COG2124	cytochrome p450
BWR18_06695	COG3588	fructose-bisphosphate aldolase
BWR18_06710	COG0114	fumarate hydratase activity
BWR18_06770	COG2186	Transcriptional regulator
BWR18_06790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BWR18_06795	COG0604	alcohol dehydrogenase
BWR18_06810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BWR18_06815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BWR18_06820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BWR18_06825	COG0415	Belongs to the DNA photolyase family
BWR18_06830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BWR18_06840	COG0494	nUDIX hydrolase
BWR18_06850	COG3264	Mechanosensitive ion channel
BWR18_06850	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BWR18_06855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BWR18_06865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BWR18_06870	COG1136	(ABC) transporter
BWR18_06895	COG2838	Isocitrate dehydrogenase
BWR18_06915	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
BWR18_06915	COG0028	Belongs to the TPP enzyme family
BWR18_06920	COG2201	protein-glutamate methylesterase activity
BWR18_06925	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BWR18_06935	COG0745	RESPONSE REGULATOR receiver
BWR18_06940	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BWR18_06945	COG0835	chemotaxis
BWR18_06970	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BWR18_06990	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BWR18_07000	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BWR18_07010	COG1561	YicC-like family, N-terminal region
BWR18_07015	COG0194	GDP metabolic process
BWR18_07030	COG0626	cystathionine gamma-synthase activity
BWR18_07035	COG5002	protein histidine kinase activity
BWR18_07045	COG0573	inorganic phosphate transmembrane transporter activity
BWR18_07050	COG0581	inorganic phosphate transmembrane transporter activity
BWR18_07055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BWR18_07060	COG0704	Plays a role in the regulation of phosphate uptake
BWR18_07065	COG0745	RESPONSE REGULATOR receiver
BWR18_07070	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_07075	COG1946	Acyl-CoA thioesterase
BWR18_07080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BWR18_07125	COG0183	Belongs to the thiolase family
BWR18_07130	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_07140	COG3321	synthase
BWR18_07140	COG0604	alcohol dehydrogenase
BWR18_07140	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_07150	COG2130	NADP-dependent
BWR18_07160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BWR18_07165	COG2771	luxR family
BWR18_07180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BWR18_07185	COG0052	Belongs to the universal ribosomal protein uS2 family
BWR18_07210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BWR18_07215	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BWR18_07220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BWR18_07230	COG1280	lysine exporter protein (LysE YggA)
BWR18_07245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BWR18_07250	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BWR18_07250	COG3743	rRNA binding
BWR18_07275	COG2020	methyltransferase activity
BWR18_07280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BWR18_07300	COG2133	pyrroloquinoline quinone binding
BWR18_07345	COG0433	COG0433 Predicted ATPase
BWR18_07360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BWR18_07365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWR18_07370	COG2989	Protein conserved in bacteria
BWR18_07380	COG0737	Belongs to the 5'-nucleotidase family
BWR18_07395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BWR18_07410	COG0719	Fe-S assembly protein
BWR18_07415	COG0396	ATPase activity
BWR18_07440	COG0719	Fe-S assembly protein
BWR18_07455	COG2945	thiolester hydrolase activity
BWR18_07470	COG0538	isocitrate dehydrogenase activity
BWR18_07480	COG1522	sequence-specific DNA binding
BWR18_07500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BWR18_07505	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BWR18_07525	COG0516	GMP reductase activity
BWR18_07525	COG0517	IMP dehydrogenase activity
BWR18_07540	COG2226	methyltransferase
BWR18_07555	COG0318	PFAM AMP-dependent synthetase and ligase
BWR18_07565	COG0166	Belongs to the GPI family
BWR18_07575	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BWR18_07585	COG5425	PFAM Usg family protein
BWR18_07590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BWR18_07595	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BWR18_07600	COG1612	heme a metabolic process
BWR18_07610	COG0352	thiamine-phosphate diphosphorylase activity
BWR18_07625	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BWR18_07625	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BWR18_07630	COG2313	pseudouridylate synthase activity
BWR18_07645	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_07650	COG4166	transmembrane transport
BWR18_07685	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BWR18_07705	COG2084	Dehydrogenase
BWR18_07725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BWR18_07730	COG1923	regulation of RNA biosynthetic process
BWR18_07735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BWR18_07740	COG0569	domain protein
BWR18_07745	COG3501	Rhs element vgr protein
BWR18_07775	COG2204	response regulator
BWR18_07780	COG5000	phosphorelay sensor kinase activity
BWR18_07785	COG2204	response regulator
BWR18_07790	COG3852	Histidine kinase
BWR18_07795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BWR18_07800	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BWR18_07805	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BWR18_07810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BWR18_07815	COG1546	Belongs to the CinA family
BWR18_07815	COG1058	Belongs to the CinA family
BWR18_07825	COG2867	negative regulation of translational initiation
BWR18_07840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BWR18_07865	COG0519	Catalyzes the synthesis of GMP from XMP
BWR18_07865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BWR18_07875	COG0697	spore germination
BWR18_07895	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BWR18_07900	COG0596	Alpha beta hydrolase
BWR18_07905	COG2326	polyphosphate kinase activity
BWR18_07910	COG1309	transcriptional regulator
BWR18_07920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BWR18_07925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BWR18_07940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BWR18_07955	COG1024	Enoyl-CoA hydratase
BWR18_07960	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BWR18_07970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWR18_07975	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BWR18_07990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BWR18_07995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BWR18_08000	COG0745	RESPONSE REGULATOR receiver
BWR18_08010	COG0482	sulfurtransferase activity
BWR18_08050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BWR18_08055	COG0416	fatty acid biosynthetic process
BWR18_08060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BWR18_08070	COG0776	regulation of translation
BWR18_08085	COG0717	Belongs to the dCTP deaminase family
BWR18_08100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BWR18_08105	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BWR18_08110	COG1472	Belongs to the glycosyl hydrolase 3 family
BWR18_08120	COG0018	arginyl-trna synthetase
BWR18_08125	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BWR18_08130	COG0316	Belongs to the HesB IscA family
BWR18_08180	COG2814	Major facilitator Superfamily
BWR18_08190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BWR18_08195	COG0215	cysteine-tRNA ligase activity
BWR18_08230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BWR18_08250	COG1278	Cold shock
BWR18_08255	COG0259	pyridoxamine-phosphate oxidase activity
BWR18_08260	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BWR18_08270	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BWR18_08285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BWR18_08300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BWR18_08310	COG0315	cyclic pyranopterin monophosphate synthase activity
BWR18_08320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BWR18_08325	COG2333	competence protein COMEC
BWR18_08325	COG0658	competence protein
BWR18_08330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWR18_08335	COG0372	Belongs to the citrate synthase family
BWR18_08350	COG1024	Enoyl-CoA hydratase
BWR18_08355	COG3088	subunit of a heme lyase
BWR18_08360	COG1138	Cytochrome C-type biogenesis protein
BWR18_08375	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BWR18_08380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BWR18_08385	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BWR18_08405	COG0668	transmembrane transport
BWR18_08430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BWR18_08440	COG0542	response to heat
BWR18_08475	COG0418	dihydroorotase activity
BWR18_08480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BWR18_08485	COG0305	Participates in initiation and elongation during chromosome replication
BWR18_08495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BWR18_08505	COG1127	ABC transporter
BWR18_08530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BWR18_08545	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_08550	COG4106	trans-aconitate 2-methyltransferase activity
BWR18_08555	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BWR18_08560	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BWR18_08565	COG1388	LysM domain
BWR18_08565	COG0739	heme binding
BWR18_08580	COG0805	protein transport
BWR18_08585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BWR18_08590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BWR18_08600	COG2378	regulation of single-species biofilm formation
BWR18_08610	COG3842	ATPase activity
BWR18_08625	COG4335	DNA alkylation repair
BWR18_08630	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_08650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BWR18_08665	COG0513	Belongs to the DEAD box helicase family
BWR18_08675	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BWR18_08685	COG1007	ATP synthesis coupled electron transport
BWR18_08700	COG0713	ATP synthesis coupled electron transport
BWR18_08725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWR18_08735	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BWR18_08785	COG0649	NAD binding
BWR18_08790	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWR18_08795	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BWR18_08805	COG1250	3-hydroxyacyl-CoA dehydrogenase
BWR18_08805	COG1024	Enoyl-CoA hydratase
BWR18_08830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BWR18_08835	COG3047	cAMP biosynthetic process
BWR18_08840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BWR18_08850	COG1960	acyl-CoA dehydrogenase activity
BWR18_08860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BWR18_08865	COG0546	phosphoglycolate phosphatase activity
BWR18_08870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BWR18_08890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BWR18_08895	COG1519	Transferase
BWR18_08900	COG0438	transferase activity, transferring glycosyl groups
BWR18_08905	COG1473	amidohydrolase
BWR18_08910	COG1473	amidohydrolase
BWR18_08915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWR18_08920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BWR18_08930	COG4172	Belongs to the ABC transporter superfamily
BWR18_08940	COG0601	transmembrane transport
BWR18_08945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWR18_08965	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BWR18_08980	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_08985	COG1943	Transposase
BWR18_08990	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BWR18_09000	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BWR18_09005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BWR18_09015	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BWR18_09025	COG2264	protein methyltransferase activity
BWR18_09040	COG0415	Belongs to the DNA photolyase family
BWR18_09050	COG0308	aminopeptidase N
BWR18_09060	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_09090	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BWR18_09155	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BWR18_09165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BWR18_09170	COG0849	cell division
BWR18_09175	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BWR18_09180	COG1181	Belongs to the D-alanine--D-alanine ligase family
BWR18_09185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BWR18_09210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BWR18_09215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BWR18_09230	COG2081	HI0933 family
BWR18_09235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BWR18_09245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BWR18_09250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BWR18_09255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BWR18_09270	COG0275	rRNA processing
BWR18_09275	COG2001	Belongs to the MraZ family
BWR18_09285	COG0489	protein tyrosine kinase activity
BWR18_09300	COG1595	DNA-templated transcription, initiation
BWR18_09305	COG0210	DNA helicase
BWR18_09315	COG1304	FMN binding
BWR18_09320	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BWR18_09330	COG0346	lactoylglutathione lyase activity
BWR18_09355	COG0131	Imidazoleglycerol-phosphate dehydratase
BWR18_09360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BWR18_09365	COG0140	phosphoribosyl-ATP diphosphatase activity
BWR18_09370	COG0107	imidazoleglycerol-phosphate synthase activity
BWR18_09385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BWR18_09395	COG1832	CoA-binding protein
BWR18_09440	COG2873	o-acetylhomoserine
BWR18_09470	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BWR18_09475	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BWR18_09480	COG1329	Transcriptional regulator
BWR18_09490	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BWR18_09520	COG1793	dna ligase
BWR18_09535	COG2267	carboxylic ester hydrolase activity
BWR18_09540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BWR18_09570	COG0564	pseudouridine synthase activity
BWR18_09580	COG0488	(ABC) transporter
BWR18_09615	COG1741	Belongs to the pirin family
BWR18_09620	COG1309	transcriptional regulator
BWR18_09640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BWR18_09650	COG5002	protein histidine kinase activity
BWR18_09650	COG5001	Diguanylate cyclase
BWR18_09650	COG3447	MASE1 domain protein
BWR18_09675	COG3706	GGDEF domain
BWR18_09725	COG0824	Thioesterase
BWR18_09725	COG1250	3-hydroxyacyl-CoA dehydrogenase
BWR18_09745	COG0667	Aldo Keto reductase
BWR18_09765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BWR18_09770	COG0840	transmembrane signaling receptor activity
BWR18_09785	COG1121	(ABC) transporter
BWR18_09790	COG4605	iron ion homeostasis
BWR18_09805	COG1522	sequence-specific DNA binding
BWR18_09825	COG0483	inositol monophosphate 1-phosphatase activity
BWR18_09830	COG2130	NADP-dependent
BWR18_09835	COG0583	DNA-binding transcription factor activity
BWR18_09865	COG0525	valine-tRNA ligase activity
BWR18_09905	COG0354	folic acid binding
BWR18_09920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BWR18_09945	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BWR18_09965	COG3842	ATPase activity
BWR18_10010	COG1222	aaa ATPase
BWR18_10065	COG1652	LysM domain
BWR18_10065	COG2823	Periplasmic or secreted lipoprotein
BWR18_10115	COG2197	response regulator
BWR18_10220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR18_10230	COG1802	Transcriptional regulator
BWR18_10235	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_10245	COG1012	belongs to the aldehyde dehydrogenase family
BWR18_10250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BWR18_10255	COG0745	RESPONSE REGULATOR receiver
BWR18_10305	COG2084	Dehydrogenase
BWR18_10310	COG3622	Belongs to the hyi family
BWR18_10320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BWR18_10340	COG0800	Aldolase
BWR18_10345	COG3734	2-keto-3-deoxy-galactonokinase
BWR18_10350	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_10360	COG0395	ABC-type sugar transport system, permease component
BWR18_10365	COG1175	transmembrane transport
BWR18_10385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BWR18_10415	COG0725	ABC transporter, periplasmic molybdate-binding protein
BWR18_10420	COG4149	molybdate abc transporter
BWR18_10425	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BWR18_10440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BWR18_10460	COG0659	secondary active sulfate transmembrane transporter activity
BWR18_10465	COG2226	methyltransferase
BWR18_10470	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BWR18_10480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BWR18_10485	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_10510	COG0612	Peptidase, M16
BWR18_10520	COG3346	SURF1 family
BWR18_10530	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BWR18_10540	COG0109	protoheme IX farnesyltransferase activity
BWR18_10550	COG0312	modulator of DNA gyrase
BWR18_10555	COG0758	DNA mediated transformation
BWR18_10560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BWR18_10560	COG1754	DNA topoisomerase type I activity
BWR18_10580	COG3920	Histidine kinase
BWR18_10615	COG4964	Belongs to the GSP D family
BWR18_10670	COG1201	RNA secondary structure unwinding
BWR18_10685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BWR18_10695	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BWR18_10705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BWR18_10710	COG0037	tRNA processing
BWR18_10720	COG2885	chlorophyll binding
BWR18_10725	COG0823	Involved in the tonB-independent uptake of proteins
BWR18_10745	COG0824	Thioesterase
BWR18_10750	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BWR18_10755	COG2951	lytic endotransglycosylase activity
BWR18_10770	COG2255	four-way junction helicase activity
BWR18_10775	COG0632	four-way junction helicase activity
BWR18_10780	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BWR18_10810	COG1183	phosphatidylcholine synthase activity
BWR18_10815	COG4974	Belongs to the 'phage' integrase family
BWR18_10825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BWR18_10840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BWR18_10855	COG3768	UPF0283 membrane protein
BWR18_10865	COG3106	COG3106 Predicted ATPase
BWR18_10870	COG0101	tRNA pseudouridine synthase activity
BWR18_10885	COG1960	acyl-CoA dehydrogenase activity
BWR18_10890	COG3246	L-lysine catabolic process to acetate
BWR18_10895	COG2308	Evidence 4 Homologs of previously reported genes of
BWR18_10920	COG1492	cobalamin metabolic process
BWR18_10970	COG2099	Precorrin-6x reductase
BWR18_10985	COG2875	Belongs to the precorrin methyltransferase family
BWR18_10990	COG1797	cobyrinic acid a,c-diamide synthase activity
BWR18_10995	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BWR18_10995	COG1648	precorrin-2 dehydrogenase activity
BWR18_11010	COG0829	nickel cation binding
BWR18_11015	COG0831	urea catabolic process
BWR18_11020	COG0832	Belongs to the urease beta subunit family
BWR18_11035	COG0804	urea catabolic process
BWR18_11045	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BWR18_11050	COG0830	nickel cation binding
BWR18_11055	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BWR18_11075	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BWR18_11090	COG4412	M6 family metalloprotease domain protein
BWR18_11090	COG3291	Pkd domain containing protein
BWR18_11115	COG1131	(ABC) transporter
BWR18_11120	COG0729	surface antigen
BWR18_11130	COG1802	Transcriptional regulator
BWR18_11135	COG3180	Ammonia monooxygenase
BWR18_11145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWR18_11155	COG0747	negative chemotaxis
BWR18_11160	COG0747	negative chemotaxis
BWR18_11165	COG0601	transmembrane transport
BWR18_11170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWR18_11190	COG4172	Belongs to the ABC transporter superfamily
BWR18_11230	COG1414	Transcriptional regulator
BWR18_11265	COG1175	transmembrane transport
BWR18_11270	COG0395	ABC-type sugar transport system, permease component
BWR18_11285	COG0235	Class ii aldolase
BWR18_11290	COG3395	kinase activity
BWR18_11310	COG0431	NADPH-dependent FMN reductase
BWR18_11320	COG1435	thymidine kinase activity
BWR18_11325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BWR18_11355	COG2197	response regulator
BWR18_11375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BWR18_11400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BWR18_11420	COG1522	sequence-specific DNA binding
BWR18_11425	COG0492	ferredoxin-NADP+ reductase activity
BWR18_11435	COG2046	Belongs to the sulfate adenylyltransferase family
BWR18_11435	COG0529	Catalyzes the synthesis of activated sulfate
BWR18_11440	COG0384	phenazine biosynthesis protein PhzF
BWR18_11455	COG0071	Belongs to the small heat shock protein (HSP20) family
BWR18_11470	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BWR18_11475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BWR18_11480	COG3454	Phosphonate metabolism
BWR18_11500	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BWR18_11515	COG1132	(ABC) transporter
BWR18_11520	COG0459	protein refolding
BWR18_11525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BWR18_11540	COG1227	inorganic diphosphatase activity
BWR18_11555	COG2030	dehydratase
BWR18_11560	COG0196	riboflavin kinase activity
BWR18_11565	COG2983	Belongs to the UPF0260 family
BWR18_11595	COG0765	amino acid transport
BWR18_11615	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BWR18_11620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BWR18_11625	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BWR18_11630	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BWR18_11635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BWR18_11650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BWR18_11675	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BWR18_11690	COG0287	Prephenate dehydrogenase
BWR18_11695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BWR18_11715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BWR18_11720	COG2818	Glycosylase
BWR18_11735	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_11740	COG0583	DNA-binding transcription factor activity
BWR18_11765	COG0142	geranyltranstransferase activity
BWR18_11770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BWR18_11785	COG0789	Transcriptional regulator
BWR18_11795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BWR18_11805	COG2201	protein-glutamate methylesterase activity
BWR18_11825	COG0746	molybdenum cofactor guanylyltransferase activity
BWR18_11865	COG1960	acyl-CoA dehydrogenase activity
BWR18_11870	COG0009	L-threonylcarbamoyladenylate synthase
BWR18_11875	COG1678	Uncharacterized ACR, COG1678
BWR18_11900	COG0521	Mo-molybdopterin cofactor biosynthetic process
BWR18_11905	COG1280	lysine exporter protein (LysE YggA)
BWR18_11910	COG1573	uracil-dna glycosylase
BWR18_11915	COG0540	Belongs to the ATCase OTCase family
BWR18_11930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BWR18_11935	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BWR18_11950	COG1280	lysine exporter protein (LysE YggA)
BWR18_11960	COG5598	trimethylamine methyltransferase
BWR18_11965	COG1012	belongs to the aldehyde dehydrogenase family
BWR18_11970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BWR18_11990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BWR18_12000	COG2885	chlorophyll binding
BWR18_12010	COG0314	molybdopterin synthase activity
BWR18_12020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BWR18_12025	COG0322	excinuclease ABC activity
BWR18_12045	COG0842	Transport permease protein
BWR18_12050	COG1131	(ABC) transporter
BWR18_12115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BWR18_12120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BWR18_12150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BWR18_12150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BWR18_12155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BWR18_12165	COG0432	Pfam Uncharacterised protein family UPF0047
BWR18_12175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BWR18_12180	COG0358	DNA primase activity
BWR18_12195	COG0446	pyridine nucleotide-disulphide oxidoreductase
BWR18_12195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BWR18_12205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWR18_12210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BWR18_12245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BWR18_12250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWR18_12255	COG3707	response regulator
BWR18_12260	COG1116	anion transmembrane transporter activity
BWR18_12260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BWR18_12265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BWR18_12270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BWR18_12275	COG1116	anion transmembrane transporter activity
BWR18_12280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BWR18_12285	COG2146	nitrite reductase [NAD(P)H] activity
BWR18_12290	COG0243	molybdopterin cofactor binding
BWR18_12295	COG1648	precorrin-2 dehydrogenase activity
BWR18_12295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BWR18_12305	COG0583	DNA-binding transcription factor activity
BWR18_12310	COG0583	DNA-binding transcription factor activity
BWR18_12315	COG0697	spore germination
BWR18_12320	COG4166	transmembrane transport
BWR18_12325	COG0601	transmembrane transport
BWR18_12330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWR18_12335	COG0444	Belongs to the ABC transporter superfamily
BWR18_12340	COG4608	Belongs to the ABC transporter superfamily
BWR18_12345	COG0667	Aldo Keto reductase
BWR18_12365	COG0189	ligase activity
BWR18_12370	COG4067	protein conserved in archaea
BWR18_12370	COG0189	ligase activity
BWR18_12375	COG2239	Acts as a magnesium transporter
BWR18_12460	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BWR18_12505	COG1230	cation diffusion facilitator family transporter
BWR18_12510	COG0789	Transcriptional regulator
BWR18_12550	COG2132	Multicopper oxidase
BWR18_12560	COG1937	Protein conserved in bacteria
BWR18_12575	COG1431	PFAM Stem cell self-renewal protein Piwi
BWR18_12580	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
BWR18_12590	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BWR18_12630	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BWR18_12680	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BWR18_12685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BWR18_12700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BWR18_12710	COG0124	histidyl-tRNA synthetase
BWR18_12725	COG0587	DNA-directed DNA polymerase activity
BWR18_12730	COG0640	Transcriptional regulator
BWR18_12745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BWR18_12795	COG2326	polyphosphate kinase activity
BWR18_12805	COG0667	Aldo Keto reductase
BWR18_12830	COG0277	FAD linked oxidase domain protein
BWR18_12855	COG0604	alcohol dehydrogenase
BWR18_12895	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BWR18_12900	COG0594	ribonuclease P activity
BWR18_12905	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BWR18_12915	COG0037	tRNA processing
BWR18_12920	COG5001	Diguanylate cyclase
BWR18_12920	COG3300	MHYT domain
BWR18_12925	COG0706	membrane insertase activity
BWR18_12935	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BWR18_12940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BWR18_12960	COG1126	abc transporter atp-binding protein
BWR18_12965	COG0765	amino acid transport
BWR18_12970	COG4597	amino acid ABC transporter
BWR18_12975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BWR18_12985	COG0546	phosphoglycolate phosphatase activity
BWR18_12990	COG0564	pseudouridine synthase activity
BWR18_12995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BWR18_13000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BWR18_13005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BWR18_13010	COG0203	ribosomal protein L17
BWR18_13015	COG0202	RNA polymerase activity
BWR18_13020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BWR18_13025	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BWR18_13030	COG0563	adenylate kinase activity
BWR18_13035	COG0201	protein transport
BWR18_13040	COG0200	Binds to the 23S rRNA
BWR18_13065	COG1841	ribosomal large subunit assembly
BWR18_13070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BWR18_13075	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BWR18_13080	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BWR18_13085	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BWR18_13090	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BWR18_13095	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BWR18_13100	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BWR18_13105	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BWR18_13110	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BWR18_13115	COG0255	Belongs to the universal ribosomal protein uL29 family
BWR18_13135	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BWR18_13140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BWR18_13145	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BWR18_13150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BWR18_13155	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BWR18_13165	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BWR18_13175	COG0089	rRNA binding
BWR18_13180	COG0088	Forms part of the polypeptide exit tunnel
BWR18_13185	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BWR18_13190	COG0051	transcription antitermination factor activity, RNA binding
BWR18_13195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BWR18_13200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BWR18_13205	COG0049	tRNA binding
BWR18_13210	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BWR18_13220	COG0697	spore germination
BWR18_13230	COG0642	Histidine kinase
BWR18_13250	COG2828	Protein conserved in bacteria
BWR18_13260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BWR18_13265	COG1053	succinate dehydrogenase
BWR18_13270	COG1609	Transcriptional regulator
BWR18_13275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BWR18_13280	COG4175	Glycine betaine
BWR18_13280	COG0517	IMP dehydrogenase activity
BWR18_13285	COG4176	ABC-type proline glycine betaine transport system permease component
BWR18_13300	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_13305	COG0583	DNA-binding transcription factor activity
BWR18_13315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BWR18_13320	COG0085	RNA polymerase activity
BWR18_13330	COG0222	ribosome binding
BWR18_13335	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BWR18_13360	COG0081	regulation of translation
BWR18_13365	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BWR18_13370	COG2885	chlorophyll binding
BWR18_13370	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BWR18_13380	COG3842	ATPase activity
BWR18_13405	COG0250	Participates in transcription elongation, termination and antitermination
BWR18_13410	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BWR18_13435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BWR18_13440	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
BWR18_13455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BWR18_13480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BWR18_13490	COG0300	oxidoreductase activity
BWR18_13525	COG1250	3-hydroxyacyl-CoA dehydrogenase
BWR18_13535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BWR18_13545	COG1660	Displays ATPase and GTPase activities
BWR18_13555	COG2205	protein histidine kinase activity
BWR18_13560	COG0745	RESPONSE REGULATOR receiver
BWR18_13565	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BWR18_13580	COG1396	sequence-specific DNA binding
BWR18_13605	COG1381	Involved in DNA repair and RecF pathway recombination
BWR18_13615	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BWR18_13620	COG0571	ribonuclease III activity
BWR18_13625	COG0681	Belongs to the peptidase S26 family
BWR18_13630	COG0736	holo-[acyl-carrier-protein] synthase activity
BWR18_13645	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BWR18_13655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BWR18_13660	COG1758	RNA polymerase activity
BWR18_13665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BWR18_13680	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BWR18_13690	COG1280	lysine exporter protein (LysE YggA)
BWR18_13705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BWR18_13710	COG0328	RNA-DNA hybrid ribonuclease activity
BWR18_13730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BWR18_13735	COG0242	peptide deformylase activity
BWR18_13740	COG0242	peptide deformylase activity
BWR18_13745	COG0242	peptide deformylase activity
BWR18_13750	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BWR18_13765	COG0435	Glutathione S-transferase
BWR18_13780	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BWR18_13805	COG2186	Transcriptional regulator
BWR18_13810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BWR18_13815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BWR18_13820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BWR18_13825	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BWR18_13830	COG0356	it plays a direct role in the translocation of protons across the membrane
BWR18_13840	COG0583	DNA-binding transcription factor activity
BWR18_13865	COG0583	DNA-binding transcription factor activity
BWR18_13870	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BWR18_13900	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_13910	COG1024	Enoyl-CoA hydratase
BWR18_13915	COG1960	acyl-CoA dehydrogenase activity
BWR18_13930	COG0251	oxidation-reduction process
BWR18_13935	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BWR18_13975	COG0228	four-way junction DNA binding
BWR18_13980	COG0778	Nitroreductase
BWR18_13995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BWR18_14000	COG0336	Belongs to the RNA methyltransferase TrmD family
BWR18_14005	COG0335	large ribosomal subunit rRNA binding
BWR18_14010	COG0254	rRNA binding
BWR18_14020	COG1719	4-vinyl reductase, 4VR
BWR18_14025	COG1032	radical SAM domain protein
BWR18_14030	COG0800	Aldolase
BWR18_14035	COG0129	dihydroxy-acid dehydratase activity
BWR18_14040	COG2151	metal-sulfur cluster biosynthetic enzyme
BWR18_14040	COG0489	protein tyrosine kinase activity
BWR18_14055	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BWR18_14085	COG1024	Enoyl-CoA hydratase
BWR18_14085	COG1250	3-hydroxyacyl-CoA dehydrogenase
BWR18_14090	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BWR18_14125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BWR18_14140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR18_14145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BWR18_14165	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BWR18_14170	COG0181	hydroxymethylbilane synthase activity
BWR18_14175	COG1960	acyl-CoA dehydrogenase activity
BWR18_14180	COG0408	coproporphyrinogen oxidase activity
BWR18_14190	COG2813	Specifically methylates the guanine in position
BWR18_14195	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BWR18_14205	COG1686	Belongs to the peptidase S11 family
BWR18_14210	COG3228	Belongs to the MtfA family
BWR18_14215	COG0583	DNA-binding transcription factor activity
BWR18_14225	COG4172	Belongs to the ABC transporter superfamily
BWR18_14230	COG4239	(ABC) transporter, permease
BWR18_14235	COG4174	ABC transporter (Permease)
BWR18_14260	COG2816	NAD+ diphosphatase activity
BWR18_14265	COG0737	Belongs to the 5'-nucleotidase family
BWR18_14280	COG1309	transcriptional regulator
BWR18_14300	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BWR18_14310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BWR18_14370	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BWR18_14375	COG0840	transmembrane signaling receptor activity
BWR18_14390	COG1522	sequence-specific DNA binding
BWR18_14395	COG0686	Belongs to the AlaDH PNT family
BWR18_14400	COG1970	mechanosensitive ion channel activity
BWR18_14405	COG0625	glutathione transferase activity
BWR18_14425	COG0583	DNA-binding transcription factor activity
BWR18_14430	COG0072	phenylalanine-tRNA ligase activity
BWR18_14430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BWR18_14445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BWR18_14475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BWR18_14480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BWR18_14490	COG0469	pyruvate kinase activity
BWR18_14525	COG4948	Mandelate Racemase Muconate Lactonizing
BWR18_14545	COG0739	heme binding
BWR18_14545	COG1196	nuclear chromosome segregation
BWR18_14545	COG0741	lytic transglycosylase activity
BWR18_14560	COG1522	sequence-specific DNA binding
BWR18_14570	COG0825	malonyl-CoA metabolic process
BWR18_14575	COG0642	Histidine kinase
BWR18_14600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BWR18_14605	COG1116	anion transmembrane transporter activity
BWR18_14615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BWR18_14625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BWR18_14630	COG0028	Belongs to the TPP enzyme family
BWR18_14640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BWR18_14645	COG2855	membrane
BWR18_14650	COG0243	molybdopterin cofactor binding
BWR18_14660	COG0437	4 iron, 4 sulfur cluster binding
BWR18_14670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BWR18_14675	COG0741	lytic transglycosylase activity
BWR18_14685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWR18_14685	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BWR18_14695	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
BWR18_14710	COG2885	chlorophyll binding
BWR18_14715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BWR18_14730	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BWR18_14735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BWR18_14750	COG1051	belongs to the nudix hydrolase family
BWR18_14765	COG0446	pyridine nucleotide-disulphide oxidoreductase
BWR18_14765	COG1902	pentaerythritol trinitrate reductase activity
BWR18_14780	COG1595	DNA-templated transcription, initiation
BWR18_14790	COG0583	DNA-binding transcription factor activity
BWR18_14795	COG2814	Major facilitator Superfamily
BWR18_14805	COG3209	COG3209 Rhs family protein
BWR18_14820	COG3501	Rhs element vgr protein
BWR18_14850	COG1489	DNA binding
BWR18_14855	COG0024	Methionine aminopeptidase
BWR18_14860	COG0742	ribosomal rna small subunit methyltransferase
BWR18_14870	COG0678	peroxiredoxin activity
BWR18_14875	COG0668	transmembrane transport
BWR18_14880	COG2154	pterin-4-alpha-carbinolamine dehydratase
BWR18_14895	COG0251	oxidation-reduction process
BWR18_14900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWR18_14920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BWR18_14930	COG0004	ammonium transporteR
BWR18_14935	COG0698	ribose 5-phosphate isomerase
BWR18_14945	COG2897	thiosulfate sulfurtransferase activity
BWR18_14950	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BWR18_14980	COG0116	Belongs to the methyltransferase superfamily
BWR18_14980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BWR18_15060	COG0583	DNA-binding transcription factor activity
BWR18_15075	COG0395	ABC-type sugar transport system, permease component
BWR18_15090	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BWR18_15100	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BWR18_15115	COG3454	Phosphonate metabolism
BWR18_15130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BWR18_15145	COG0596	Alpha beta hydrolase
BWR18_15155	COG0071	Belongs to the small heat shock protein (HSP20) family
BWR18_15165	COG3591	Belongs to the peptidase S1B family
BWR18_15170	COG0247	lactate metabolic process
BWR18_15180	COG0277	FAD linked oxidase domain protein
BWR18_15185	COG0277	FAD linked oxidase domain protein
BWR18_15200	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BWR18_15205	COG0799	negative regulation of ribosome biogenesis
BWR18_15230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BWR18_15235	COG3264	Mechanosensitive ion channel
BWR18_15235	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BWR18_15240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BWR18_15255	COG0066	3-isopropylmalate dehydratase activity
BWR18_15270	COG0473	3-isopropylmalate dehydrogenase activity
BWR18_15275	COG0697	spore germination
BWR18_15305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BWR18_15350	COG0745	RESPONSE REGULATOR receiver
BWR18_15360	COG1609	Transcriptional regulator
BWR18_15380	COG3842	ATPase activity
BWR18_15385	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BWR18_15405	COG3093	addiction module antidote protein HigA
BWR18_15415	COG1404	Belongs to the peptidase S8 family
BWR18_15450	COG1609	Transcriptional regulator
BWR18_15455	COG3214	Protein conserved in bacteria
BWR18_15465	COG1984	allophanate hydrolase subunit 2
BWR18_15470	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BWR18_15485	COG1231	oxidoreductase activity
BWR18_15490	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BWR18_15500	COG1312	Catalyzes the dehydration of D-mannonate
BWR18_15505	COG0673	inositol 2-dehydrogenase activity
BWR18_15520	COG1904	glucuronate isomerase
BWR18_15525	COG0246	Mannitol dehydrogenase
BWR18_15530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BWR18_15535	COG0697	spore germination
BWR18_15550	COG2721	sulfolactate sulfo-lyase activity
BWR18_15575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BWR18_15580	COG2084	Dehydrogenase
BWR18_15585	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_15590	COG0129	dihydroxy-acid dehydratase activity
BWR18_15600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWR18_15605	COG4948	Mandelate Racemase Muconate Lactonizing
BWR18_15610	COG0793	Belongs to the peptidase S41A family
BWR18_15620	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BWR18_15635	COG0587	DNA-directed DNA polymerase activity
BWR18_15655	COG0840	transmembrane signaling receptor activity
BWR18_15660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BWR18_15660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BWR18_15675	COG4603	Belongs to the binding-protein-dependent transport system permease family
BWR18_15695	COG0402	S-adenosylhomocysteine deaminase activity
BWR18_15705	COG0010	Belongs to the arginase family
BWR18_15710	COG1116	anion transmembrane transporter activity
BWR18_15710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BWR18_15725	COG0745	RESPONSE REGULATOR receiver
BWR18_15755	COG0495	leucyl-tRNA aminoacylation
BWR18_15780	COG3264	Mechanosensitive ion channel
BWR18_15780	COG1196	nuclear chromosome segregation
BWR18_15790	COG1024	Enoyl-CoA hydratase
BWR18_15795	COG4221	oxidoreductase activity
BWR18_15805	COG0312	modulator of DNA gyrase
BWR18_15825	COG1663	tetraacyldisaccharide 4'-kinase activity
BWR18_15855	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BWR18_15860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BWR18_15895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BWR18_15915	COG0288	reversible hydration of carbon dioxide
BWR18_15925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BWR18_15930	COG0791	NLP P60 protein
BWR18_15940	COG2050	protein possibly involved in aromatic compounds catabolism
BWR18_15960	COG2132	Multicopper oxidase
BWR18_16035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BWR18_16040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BWR18_16065	COG2808	Putative FMN-binding domain
BWR18_16075	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BWR18_16085	COG4143	(ABC) transporter
BWR18_16090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BWR18_16095	COG1309	transcriptional regulator
BWR18_16105	COG0697	spore germination
BWR18_16115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BWR18_16120	COG1846	Transcriptional regulator
BWR18_16125	COG0745	RESPONSE REGULATOR receiver
BWR18_16130	COG0123	including yeast histone deacetylase and acetoin utilization protein
BWR18_16135	COG1722	exodeoxyribonuclease VII activity
BWR18_16140	COG0142	geranyltranstransferase activity
BWR18_16145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BWR18_16180	COG2171	N-acyltransferase activity
BWR18_16210	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BWR18_16230	COG0560	Phosphoserine phosphatase
BWR18_16230	COG3830	Belongs to the UPF0237 family
BWR18_16235	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BWR18_16240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BWR18_16250	COG1280	lysine exporter protein (LysE YggA)
BWR18_16255	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BWR18_16260	COG1063	alcohol dehydrogenase
BWR18_16265	COG0156	8-amino-7-oxononanoate synthase activity
BWR18_16270	COG1396	sequence-specific DNA binding
BWR18_16275	COG0183	Belongs to the thiolase family
BWR18_16285	COG2226	methyltransferase
BWR18_16290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BWR18_16295	COG1024	Enoyl-CoA hydratase
BWR18_16310	COG0268	Binds directly to 16S ribosomal RNA
BWR18_16315	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BWR18_16320	COG0592	DNA-directed DNA polymerase activity
BWR18_16325	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BWR18_16330	COG1280	lysine exporter protein (LysE YggA)
BWR18_16335	COG0187	DNA topoisomerase II activity
BWR18_16365	COG2350	Protein conserved in bacteria
BWR18_16370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BWR18_16375	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BWR18_16405	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BWR18_16415	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BWR18_16425	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BWR18_16430	COG1999	signal sequence binding
BWR18_16445	COG0802	atpase or kinase
BWR18_16450	COG3178	'Phosphotransferase
BWR18_16455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BWR18_16460	COG2887	Belongs to the helicase family. UvrD subfamily
BWR18_16480	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BWR18_16485	COG0667	Aldo Keto reductase
BWR18_16495	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BWR18_16530	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BWR18_16535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BWR18_16540	COG0237	dephospho-CoA kinase activity
BWR18_16545	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BWR18_16550	COG0424	maF-like protein
BWR18_16560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BWR18_16565	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BWR18_16570	COG0445	tRNA wobble uridine modification
BWR18_16575	COG0357	Ribosomal RNA small subunit methyltransferase G
BWR18_16580	COG1192	Involved in chromosome partitioning
BWR18_16585	COG1475	DNA binding
BWR18_16590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BWR18_16595	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BWR18_16600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BWR18_16605	COG1420	regulation of RNA biosynthetic process
BWR18_16610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BWR18_16615	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BWR18_16620	COG0281	malic enzyme
BWR18_16620	COG0280	phosphate acetyltransferase
BWR18_16630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BWR18_16640	COG0137	argininosuccinate synthase activity
BWR18_16645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BWR18_16655	COG0745	RESPONSE REGULATOR receiver
BWR18_16660	COG2816	NAD+ diphosphatase activity
BWR18_16670	COG0494	nUDIX hydrolase
BWR18_16675	COG0617	tRNA 3'-terminal CCA addition
BWR18_16680	COG1132	(ABC) transporter
BWR18_16685	COG1132	(ABC) transporter
BWR18_16690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BWR18_16700	COG3034	peptidoglycan biosynthetic process
BWR18_16730	COG1040	competence protein
BWR18_16735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BWR18_16750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BWR18_16765	COG0779	Required for maturation of 30S ribosomal subunits
BWR18_16780	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BWR18_16785	COG0494	nUDIX hydrolase
BWR18_16790	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BWR18_16795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BWR18_16800	COG0653	protein targeting
BWR18_16815	COG2003	Belongs to the UPF0758 family
BWR18_16825	COG0484	heat shock protein binding
BWR18_16830	COG0443	Heat shock 70 kDa protein
BWR18_16835	COG3145	DNA-N1-methyladenine dioxygenase activity
BWR18_16855	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BWR18_16870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BWR18_16895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BWR18_16900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BWR18_16905	COG1137	ATPase activity
BWR18_16920	COG0517	IMP dehydrogenase activity
BWR18_16920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BWR18_16925	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BWR18_16935	COG2030	dehydratase
BWR18_16935	COG1012	belongs to the aldehyde dehydrogenase family
BWR18_16940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BWR18_16950	COG2151	metal-sulfur cluster biosynthetic enzyme
BWR18_16955	COG3396	Phenylacetate-CoA oxygenase
BWR18_16960	COG3460	Phenylacetate-CoA oxygenase
BWR18_16970	COG3396	Phenylacetate-CoA oxygenase
BWR18_16980	COG0022	dehydrogenase e1 component
BWR18_16985	COG1063	alcohol dehydrogenase
BWR18_16990	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_17020	COG0745	RESPONSE REGULATOR receiver
BWR18_17025	COG0642	Histidine kinase
BWR18_17050	COG0129	dihydroxy-acid dehydratase activity
BWR18_17055	COG1132	(ABC) transporter
BWR18_17065	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BWR18_17070	COG0285	dihydrofolate synthase activity
BWR18_17080	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BWR18_17095	COG2423	ornithine cyclodeaminase activity
BWR18_17105	COG1671	Belongs to the UPF0178 family
BWR18_17110	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BWR18_17115	COG0679	Auxin Efflux Carrier
BWR18_17125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BWR18_17155	COG0583	DNA-binding transcription factor activity
BWR18_17180	COG1053	succinate dehydrogenase
BWR18_17195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BWR18_17200	COG0778	Nitroreductase
BWR18_17205	COG1063	alcohol dehydrogenase
BWR18_17225	COG1968	undecaprenyl-diphosphatase activity
BWR18_17260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BWR18_17270	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BWR18_17285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BWR18_17290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BWR18_17295	COG0386	Belongs to the glutathione peroxidase family
BWR18_17315	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BWR18_17365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BWR18_17370	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BWR18_17390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BWR18_17395	COG2153	protein acetylation
BWR18_17415	COG2378	regulation of single-species biofilm formation
BWR18_17420	COG2951	lytic endotransglycosylase activity
BWR18_17440	COG3842	ATPase activity
BWR18_17445	COG0006	proline dipeptidase activity
BWR18_17460	COG3842	ATPase activity
BWR18_17465	COG1176	ABC-type spermidine putrescine transport system, permease component I
BWR18_17470	COG1177	transmembrane transport
BWR18_17475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWR18_17510	COG5443	negative regulation of bacterial-type flagellum assembly
BWR18_17520	COG1157	protein secretion by the type III secretion system
BWR18_17525	COG1815	bacterial-type flagellum-dependent cell motility
BWR18_17530	COG1558	bacterial-type flagellum-dependent cell motility
BWR18_17535	COG1677	Flagellar hook-basal body complex protein FliE
BWR18_17545	COG4786	Flagellar basal body rod
BWR18_17550	COG4786	Flagellar basal body rod
BWR18_17560	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BWR18_17575	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BWR18_17580	COG1684	flagellar biosynthetic protein fliR
BWR18_17585	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BWR18_17600	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BWR18_17620	COG1766	The M ring may be actively involved in energy transduction
BWR18_17630	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BWR18_17635	COG1338	Plays a role in the flagellum-specific transport system
BWR18_17640	COG1706	bacterial-type flagellum-dependent cell motility
BWR18_17660	COG1360	Flagellar Motor Protein
BWR18_17665	COG2271	Major facilitator Superfamily
BWR18_17675	COG1335	isochorismatase
BWR18_17680	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BWR18_17700	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BWR18_17710	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
BWR18_17735	COG0514	ATP-dependent DNA helicase (RecQ)
BWR18_17740	COG3022	response to hydroperoxide
BWR18_17745	COG0784	Response regulator, receiver
BWR18_17745	COG2205	protein histidine kinase activity
BWR18_17745	COG5002	protein histidine kinase activity
BWR18_17750	COG2373	Large extracellular alpha-helical protein
BWR18_17755	COG4953	penicillin-binding protein 1C
BWR18_17775	COG0714	Associated with various cellular activities
BWR18_17790	COG3622	Belongs to the hyi family
BWR18_17810	COG0708	Exodeoxyribonuclease III
BWR18_17820	COG3118	belongs to the thioredoxin family
BWR18_17825	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BWR18_17830	COG2835	tetraacyldisaccharide 4'-kinase activity
BWR18_17835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BWR18_17840	COG0154	amidase activity
BWR18_17845	COG0436	Aminotransferase
BWR18_17850	COG1674	ftsk spoiiie
BWR18_17875	COG0405	Gamma-glutamyltransferase
BWR18_17885	COG1366	Belongs to the anti-sigma-factor antagonist family
BWR18_17890	COG0183	Belongs to the thiolase family
BWR18_17940	COG0564	pseudouridine synthase activity
BWR18_17950	COG0450	alkyl hydroperoxide reductase
BWR18_17960	COG1185	polyribonucleotide nucleotidyltransferase activity
BWR18_17975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BWR18_17995	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BWR18_18005	COG3698	Phosphodiester glycosidase
BWR18_18010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BWR18_18015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BWR18_18030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BWR18_18030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BWR18_18040	COG0138	bifunctional purine biosynthesis protein purh
BWR18_18055	COG0612	Peptidase, M16
BWR18_18060	COG0612	Peptidase, M16
BWR18_18080	COG0745	RESPONSE REGULATOR receiver
BWR18_18085	COG2205	protein histidine kinase activity
BWR18_18090	COG0803	Belongs to the bacterial solute-binding protein 9 family
BWR18_18095	COG1121	(ABC) transporter
BWR18_18100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BWR18_18100	COG1321	iron dependent repressor
BWR18_18105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BWR18_18115	COG2351	hydroxyisourate hydrolase activity
BWR18_18125	COG3257	ureidoglycine aminohydrolase activity
BWR18_18130	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
BWR18_18140	COG1116	anion transmembrane transporter activity
BWR18_18170	COG1271	oxidase subunit
BWR18_18175	COG1294	oxidase, subunit
BWR18_18185	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BWR18_18190	COG1322	Protein conserved in bacteria
BWR18_18200	COG3806	Anti-sigma factor
BWR18_18205	COG1595	DNA-templated transcription, initiation
BWR18_18230	COG0300	oxidoreductase activity
BWR18_18245	COG0625	glutathione transferase activity
BWR18_18260	COG3383	formate dehydrogenase (NAD+) activity
BWR18_18265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BWR18_18280	COG3852	Histidine kinase
BWR18_18285	COG1022	Amp-dependent synthetase and ligase
BWR18_18295	COG0411	ABC transporter
BWR18_18305	COG0559	Belongs to the binding-protein-dependent transport system permease family
BWR18_18345	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BWR18_18350	COG5507	3-demethylubiquinone-9 3-methyltransferase
BWR18_18355	COG1178	ABC-type Fe3 transport system permease component
BWR18_18375	COG0625	glutathione transferase activity
BWR18_18395	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BWR18_18410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BWR18_18420	COG0284	orotidine-5'-phosphate decarboxylase activity
BWR18_18445	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BWR18_18450	COG0069	glutamate synthase activity
BWR18_18455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BWR18_18460	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BWR18_18495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BWR18_18535	COG0583	DNA-binding transcription factor activity
BWR18_18540	COG2080	2 iron, 2 sulfur cluster binding
BWR18_18545	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BWR18_18555	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BWR18_18570	COG4221	oxidoreductase activity
BWR18_18575	COG2207	Transcriptional regulator
BWR18_18585	COG3713	MltA-interacting MipA family protein
BWR18_18600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWR18_18620	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BWR18_18625	COG3485	protocatechuate 3,4-dioxygenase
BWR18_18630	COG3485	protocatechuate 3,4-dioxygenase
BWR18_18640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BWR18_18690	COG2514	catechol 2,3-dioxygenase activity
BWR18_18700	COG0745	RESPONSE REGULATOR receiver
BWR18_18710	COG0683	leucine binding
BWR18_18725	COG1129	ABC transporter
BWR18_18730	COG0410	ABC transporter
BWR18_18765	COG0583	DNA-binding transcription factor activity
BWR18_18795	COG0180	Tryptophanyl-tRNA synthetase
BWR18_18820	COG0366	Alpha amylase catalytic
BWR18_18825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BWR18_18830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BWR18_18835	COG0297	glycogen (starch) synthase activity
BWR18_18845	COG0033	Phosphoglucomutase
BWR18_18850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BWR18_18860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BWR18_18865	COG0792	nuclease activity
BWR18_18880	COG0606	chelatase, subunit chli
BWR18_18900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BWR18_18915	COG0756	dUTP diphosphatase activity
BWR18_18920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BWR18_18925	COG0339	signal peptide processing
BWR18_18935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BWR18_18950	COG0772	Belongs to the SEDS family
BWR18_18980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BWR18_18990	COG3046	protein related to deoxyribodipyrimidine photolyase
BWR18_19030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWR18_19035	COG0534	Mate efflux family protein
BWR18_19045	COG0483	inositol monophosphate 1-phosphatase activity
BWR18_19055	COG4181	ATPase activity
BWR18_19060	COG2755	lipolytic protein G-D-S-L family
BWR18_19070	COG1278	Cold shock
BWR18_19075	COG0493	'glutamate synthase
BWR18_19090	COG1309	transcriptional regulator
BWR18_19120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BWR18_19125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BWR18_19145	COG0488	(ABC) transporter
BWR18_19160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BWR18_19190	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
BWR18_19215	COG1252	NADH dehydrogenase
BWR18_19250	COG1278	Cold shock
BWR18_19255	COG1943	Transposase
BWR18_19270	COG0318	PFAM AMP-dependent synthetase and ligase
BWR18_19275	COG1802	Transcriptional regulator
BWR18_19280	COG0277	FAD linked oxidase domain protein
BWR18_19280	COG0247	lactate metabolic process
BWR18_19285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BWR18_19290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR18_19325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BWR18_19335	COG1414	Transcriptional regulator
BWR18_19345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BWR18_19380	COG1215	transferase activity, transferring glycosyl groups
BWR18_19390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BWR18_19400	COG1132	(ABC) transporter
BWR18_19445	COG0546	phosphoglycolate phosphatase activity
BWR18_19445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BWR18_19455	COG0277	FAD linked oxidase domain protein
BWR18_19460	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_19470	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BWR18_19490	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
BWR18_19510	COG1269	ATP hydrolysis coupled proton transport
BWR18_19540	COG3243	poly(R)-hydroxyalkanoic acid synthase
BWR18_19545	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BWR18_19555	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BWR18_19560	COG1192	Involved in chromosome partitioning
BWR18_19565	COG1475	DNA binding
BWR18_19590	COG1012	belongs to the aldehyde dehydrogenase family
BWR18_19595	COG0318	PFAM AMP-dependent synthetase and ligase
BWR18_19625	COG4558	Periplasmic binding protein
BWR18_19630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BWR18_19635	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BWR18_19640	COG1840	ABC-type Fe3 transport system, periplasmic component
BWR18_19700	COG4774	siderophore transport
BWR18_19700	COG1629	transport
BWR18_19740	COG0811	peptide transport
BWR18_19750	COG1192	Involved in chromosome partitioning
BWR18_19760	COG1414	Transcriptional regulator
BWR18_19765	COG4771	TonB-dependent receptor
BWR18_19770	COG1320	monovalent cation:proton antiporter activity
BWR18_19775	COG2212	antiporter activity
BWR18_19790	COG1006	Multisubunit Na H antiporter MnhC subunit
BWR18_19795	COG2111	Na H antiporter
BWR18_19805	COG0589	response to stress
BWR18_19825	COG0488	(ABC) transporter
BWR18_19835	COG1120	ATPase activity
BWR18_19840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BWR18_19855	COG2353	YceI-like domain
BWR18_19885	COG1116	anion transmembrane transporter activity
BWR18_19890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BWR18_19905	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BWR18_19920	COG0395	ABC-type sugar transport system, permease component
BWR18_19935	COG3842	ATPase activity
BWR18_19940	COG1609	Transcriptional regulator
BWR18_19950	COG1879	ABC-type sugar transport system periplasmic component
BWR18_19955	COG1172	Belongs to the binding-protein-dependent transport system permease family
BWR18_19970	COG1172	Belongs to the binding-protein-dependent transport system permease family
BWR18_19975	COG1129	ABC transporter
BWR18_19980	COG1609	Transcriptional regulator
BWR18_19990	COG1609	Transcriptional regulator
BWR18_20000	COG2084	Dehydrogenase
BWR18_20005	COG3265	gluconokinase activity
BWR18_20010	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_20015	COG1063	alcohol dehydrogenase
BWR18_20025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BWR18_20035	COG1280	lysine exporter protein (LysE YggA)
BWR18_20040	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BWR18_20045	COG0644	oxidoreductase
BWR18_20050	COG2211	Major facilitator Superfamily
BWR18_20055	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BWR18_20075	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BWR18_20080	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BWR18_20085	COG1429	ligase activity, forming nitrogen-metal bonds
BWR18_20090	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BWR18_20105	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BWR18_20125	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BWR18_20135	COG0156	8-amino-7-oxononanoate synthase activity
BWR18_20165	COG1192	Involved in chromosome partitioning
BWR18_20170	COG1475	DNA binding
BWR18_20180	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BWR18_20185	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BWR18_20200	COG1562	ergosterol biosynthetic process
BWR18_20205	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BWR18_20215	COG5621	secreted hydrolase
BWR18_20220	COG1233	COG1233 Phytoene dehydrogenase and related
BWR18_20225	COG0142	geranyltranstransferase activity
BWR18_20230	COG0500	methyltransferase
BWR18_20240	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BWR18_20250	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BWR18_20255	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BWR18_20290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BWR18_20305	COG3191	aminopeptidase activity
BWR18_20310	COG0662	Cupin 2, conserved barrel domain protein
BWR18_20325	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_20345	COG4172	Belongs to the ABC transporter superfamily
BWR18_20360	COG1309	transcriptional regulator
BWR18_20385	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BWR18_20390	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BWR18_20425	COG0563	adenylate kinase activity
BWR18_20435	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BWR18_20450	COG5002	protein histidine kinase activity
BWR18_20450	COG2176	DNA-directed DNA polymerase activity
BWR18_20465	COG2205	protein histidine kinase activity
BWR18_20465	COG5002	protein histidine kinase activity
BWR18_20465	COG0784	Response regulator, receiver
BWR18_20490	COG1116	anion transmembrane transporter activity
BWR18_20505	COG1131	(ABC) transporter
BWR18_20560	COG3901	Regulator of nitric oxide reductase transcription
BWR18_20560	COG0348	domain, Protein
BWR18_20575	COG0535	radical SAM domain protein
BWR18_20585	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BWR18_20615	COG0545	Peptidyl-prolyl cis-trans isomerase
BWR18_20620	COG0437	4 iron, 4 sulfur cluster binding
BWR18_20625	COG0243	molybdopterin cofactor binding
BWR18_20625	COG3383	formate dehydrogenase (NAD+) activity
BWR18_20665	COG0489	protein tyrosine kinase activity
BWR18_20760	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BWR18_20760	COG0662	Cupin 2, conserved barrel domain protein
BWR18_20790	COG1192	Involved in chromosome partitioning
BWR18_20795	COG1475	DNA binding
BWR18_20805	COG1459	type II secretion system
BWR18_20915	COG2192	nodulation
BWR18_21000	COG3267	Type II secretory pathway component ExeA
BWR18_21000	COG3409	Peptidoglycan-binding domain 1 protein
BWR18_21015	COG1192	Involved in chromosome partitioning
BWR18_21085	COG1028	Short-chain dehydrogenase reductase Sdr
BWR18_21180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BWR18_21240	COG1091	dTDP-4-dehydrorhamnose reductase activity
BWR18_21270	COG1192	Involved in chromosome partitioning