locus-tag	class	description
A7K99_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7K99_00010	COG0592	DNA-directed DNA polymerase activity
A7K99_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A7K99_00020	COG0187	DNA topoisomerase II activity
A7K99_00025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7K99_00025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7K99_00035	COG0561	phosphatase activity
A7K99_00055	COG0823	Involved in the tonB-independent uptake of proteins
A7K99_00060	COG5645	(Lipo)protein
A7K99_00065	COG0071	Belongs to the small heat shock protein (HSP20) family
A7K99_00075	COG3977	Valine--pyruvate aminotransferase
A7K99_00085	COG1609	Transcriptional regulator
A7K99_00090	COG2818	Glycosylase
A7K99_00100	COG1484	DNA-dependent DNA replication
A7K99_00105	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_00110	COG1942	4-Oxalocrotonate Tautomerase
A7K99_00115	COG0431	NADPH-dependent FMN reductase
A7K99_00120	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A7K99_00125	COG0113	porphobilinogen synthase activity
A7K99_00140	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A7K99_00145	COG0425	Belongs to the sulfur carrier protein TusA family
A7K99_00150	COG3714	YhhN family
A7K99_00160	COG3776	membrane
A7K99_00165	COG0742	ribosomal rna small subunit methyltransferase
A7K99_00170	COG0552	protein localization to endoplasmic reticulum
A7K99_00175	COG2884	Cell division ATP-binding protein ftsE
A7K99_00180	COG2177	Part of the ABC transporter FtsEX involved in
A7K99_00190	COG0456	acetyltransferase
A7K99_00205	COG0395	ABC-type sugar transport system, permease component
A7K99_00210	COG3842	ATPase activity
A7K99_00215	COG0584	glycerophosphoryl diester phosphodiesterase
A7K99_00225	COG1741	Belongs to the pirin family
A7K99_00230	COG1609	Transcriptional regulator
A7K99_00235	COG3265	gluconokinase activity
A7K99_00240	COG2610	gluconate transmembrane transporter activity
A7K99_00245	COG2095	MarC family integral membrane protein
A7K99_00250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A7K99_00255	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A7K99_00260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7K99_00270	COG1349	DNA-binding transcription factor activity
A7K99_00275	COG0316	Belongs to the HesB IscA family
A7K99_00275	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A7K99_00285	COG2267	carboxylic ester hydrolase activity
A7K99_00300	COG2183	response to ionizing radiation
A7K99_00305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7K99_00310	COG0745	RESPONSE REGULATOR receiver
A7K99_00320	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A7K99_00325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A7K99_00330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A7K99_00340	COG0494	nUDIX hydrolase
A7K99_00345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A7K99_00385	COG3266	domain, Protein
A7K99_00385	COG3266	domain, Protein
A7K99_00395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A7K99_00400	COG0546	phosphoglycolate phosphatase activity
A7K99_00410	COG0738	Major facilitator superfamily
A7K99_00430	COG1289	transmembrane transporter activity
A7K99_00440	COG1765	OsmC-like protein
A7K99_00445	COG3954	Phosphoribulokinase
A7K99_00455	COG0429	hydrolase of the alpha beta-hydrolase fold
A7K99_00465	COG0488	(ABC) transporter
A7K99_00470	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7K99_00475	COG0475	glutathione-regulated potassium exporter activity
A7K99_00475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A7K99_00480	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A7K99_00485	COG1047	Peptidyl-prolyl cis-trans
A7K99_00490	COG2900	Belongs to the SlyX family
A7K99_00495	COG0545	Peptidyl-prolyl cis-trans isomerase
A7K99_00500	COG2964	Protein conserved in bacteria
A7K99_00510	COG2923	Belongs to the DsrF TusC family
A7K99_00520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A7K99_00550	COG0051	transcription antitermination factor activity, RNA binding
A7K99_00555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A7K99_00580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A7K99_00590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A7K99_00605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A7K99_00615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A7K99_00625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A7K99_00630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A7K99_00635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A7K99_00645	COG1841	ribosomal large subunit assembly
A7K99_00650	COG0200	Binds to the 23S rRNA
A7K99_00655	COG0201	protein transport
A7K99_00665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A7K99_00680	COG0203	ribosomal protein L17
A7K99_00690	COG3036	rescue of stalled ribosome
A7K99_00695	COG1970	mechanosensitive ion channel activity
A7K99_00700	COG0569	domain protein
A7K99_00705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A7K99_00705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7K99_00710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7K99_00720	COG0758	DNA mediated transformation
A7K99_00730	COG0551	DNA topoisomerase type I activity
A7K99_00740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7K99_00750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A7K99_00785	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A7K99_00790	COG1301	dicarboxylic acid transport
A7K99_00795	COG1802	Transcriptional regulator
A7K99_00805	COG1929	Belongs to the glycerate kinase type-1 family
A7K99_00810	COG2807	transmembrane transport
A7K99_00815	COG2207	Transcriptional regulator
A7K99_00850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7K99_00855	COG2264	protein methyltransferase activity
A7K99_00860	COG4145	pantothenate transmembrane transporter activity
A7K99_00865	COG3924	membrane
A7K99_00870	COG0439	Biotin carboxylase
A7K99_00875	COG0511	ligase activity, forming carbon-carbon bonds
A7K99_00880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A7K99_00885	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A7K99_00895	COG2199	diguanylate cyclase activity
A7K99_00895	COG2200	EAL domain
A7K99_00900	COG1077	Cell shape determining protein MreB Mrl
A7K99_00905	COG1792	Involved in formation and maintenance of cell shape
A7K99_00910	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A7K99_00920	COG1530	ribonuclease E activity
A7K99_00925	COG3164	Protein of unknown function
A7K99_00930	COG0312	modulator of DNA gyrase
A7K99_00935	COG0583	DNA-binding transcription factor activity
A7K99_00945	COG1566	PFAM secretion protein HlyD family protein
A7K99_00950	COG1289	transmembrane transporter activity
A7K99_00960	COG1438	arginine binding
A7K99_00965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7K99_00970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7K99_00975	COG3105	Protein conserved in bacteria
A7K99_00980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A7K99_00985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A7K99_00990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A7K99_00995	COG0625	glutathione transferase activity
A7K99_01000	COG2969	positive regulation of protein catabolic process
A7K99_01005	COG0493	'glutamate synthase
A7K99_01010	COG0070	glutamate synthase
A7K99_01010	COG0067	glutamate synthase
A7K99_01010	COG0069	glutamate synthase activity
A7K99_01015	COG5002	protein histidine kinase activity
A7K99_01015	COG2198	Histidine kinase
A7K99_01015	COG0784	Response regulator, receiver
A7K99_01030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_01035	COG1660	Displays ATPase and GTPase activities
A7K99_01045	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A7K99_01050	COG1137	ATPase activity
A7K99_01055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A7K99_01060	COG3117	lipopolysaccharide transmembrane transporter activity
A7K99_01065	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A7K99_01075	COG0530	calcium, potassium:sodium antiporter activity
A7K99_01080	COG1127	ABC transporter
A7K99_01085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7K99_01090	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A7K99_01095	COG2854	intermembrane phospholipid transfer
A7K99_01100	COG3113	response to antibiotic
A7K99_01105	COG5007	Belongs to the BolA IbaG family
A7K99_01115	COG3423	Transcriptional regulator
A7K99_01125	COG0142	geranyltranstransferase activity
A7K99_01130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A7K99_01135	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A7K99_01140	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A7K99_01145	COG2050	protein possibly involved in aromatic compounds catabolism
A7K99_01150	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_01155	COG3433	isochorismatase activity
A7K99_01155	COG1535	isochorismatase
A7K99_01160	COG1021	2,3-dihydroxybenzoate-AMP ligase
A7K99_01165	COG1169	isochorismate synthase
A7K99_01170	COG4592	Periplasmic binding protein
A7K99_01175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7K99_01180	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7K99_01185	COG1120	ATPase activity
A7K99_01190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7K99_01190	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A7K99_01200	COG2382	esterase
A7K99_01205	COG4771	TonB-dependent receptor
A7K99_01210	COG2027	D-alanyl-D-alanine carboxypeptidase
A7K99_01215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7K99_01220	COG1534	Rna-binding protein
A7K99_01225	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A7K99_01230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A7K99_01235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A7K99_01240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7K99_01245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A7K99_01260	COG0779	Required for maturation of 30S ribosomal subunits
A7K99_01280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A7K99_01285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A7K99_01290	COG1185	polyribonucleotide nucleotidyltransferase activity
A7K99_01300	COG0513	Belongs to the DEAD box helicase family
A7K99_01305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_01325	COG3153	acetyltransferase
A7K99_01330	COG2827	Endonuclease containing a URI domain
A7K99_01335	COG3787	Belongs to the UPF0306 family
A7K99_01345	COG0602	queuosine metabolic process
A7K99_01370	COG1438	arginine binding
A7K99_01375	COG1288	antiporter activity
A7K99_01385	COG0549	Belongs to the carbamate kinase family
A7K99_01390	COG2235	arginine
A7K99_01400	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
A7K99_01425	COG1126	abc transporter atp-binding protein
A7K99_01430	COG0765	amino acid transport
A7K99_01435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_01445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A7K99_01455	COG0154	amidase activity
A7K99_01470	COG0765	amino acid transport
A7K99_01475	COG0765	amino acid transport
A7K99_01480	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A7K99_01490	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A7K99_01495	COG0525	valine-tRNA ligase activity
A7K99_01500	COG2927	DNA polymerase III (CHI subunit)
A7K99_01505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A7K99_01510	COG0795	lipopolysaccharide-transporting ATPase activity
A7K99_01515	COG0795	lipopolysaccharide-transporting ATPase activity
A7K99_01520	COG3210	domain, Protein
A7K99_01520	COG3468	outer membrane autotransporter barrel domain protein
A7K99_01525	COG2733	membrane
A7K99_01530	COG0583	DNA-binding transcription factor activity
A7K99_01540	COG0477	Major facilitator Superfamily
A7K99_01545	COG0433	COG0433 Predicted ATPase
A7K99_01605	COG2963	transposase activity
A7K99_01685	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A7K99_01685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7K99_01690	COG3835	regulator
A7K99_01695	COG3875	lactate racemase activity
A7K99_01705	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A7K99_01715	COG1691	(AIR) carboxylase
A7K99_01725	COG3708	Transcriptional regulator
A7K99_01725	COG2207	Transcriptional regulator
A7K99_01750	COG2814	Major facilitator Superfamily
A7K99_01805	COG0477	Major facilitator Superfamily
A7K99_01820	COG1741	Belongs to the pirin family
A7K99_01865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_01890	COG2011	ABC-type metal ion transport system permease component
A7K99_01900	COG0477	Major facilitator Superfamily
A7K99_01930	COG2223	nitrite transmembrane transporter activity
A7K99_01940	COG1609	Transcriptional regulator
A7K99_01955	COG1846	Transcriptional regulator
A7K99_01970	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_01980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_01995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7K99_02000	COG4948	Mandelate Racemase Muconate Lactonizing
A7K99_02005	COG0006	proline dipeptidase activity
A7K99_02010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7K99_02015	COG0504	CTP synthase activity
A7K99_02025	COG0384	phenazine biosynthesis protein PhzF
A7K99_02035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7K99_02040	COG3275	phosphorelay sensor kinase activity
A7K99_02050	COG0523	cobalamin synthesis protein
A7K99_02055	COG2879	small protein
A7K99_02060	COG1966	Carbon starvation protein
A7K99_02065	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_02065	COG2213	PTS system mannitol-specific
A7K99_02070	COG0246	Mannitol dehydrogenase
A7K99_02075	COG3722	fumarate hydratase activity
A7K99_02085	COG3210	domain, Protein
A7K99_02135	COG1129	ABC transporter
A7K99_02140	COG0410	ABC transporter
A7K99_02160	COG2271	Major facilitator Superfamily
A7K99_02165	COG0371	Dehydrogenase
A7K99_02170	COG1064	alcohol dehydrogenase
A7K99_02175	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A7K99_02175	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A7K99_02185	COG1053	succinate dehydrogenase
A7K99_02195	COG4608	Belongs to the ABC transporter superfamily
A7K99_02200	COG0444	Belongs to the ABC transporter superfamily
A7K99_02205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7K99_02210	COG0601	transmembrane transport
A7K99_02215	COG0747	negative chemotaxis
A7K99_02220	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A7K99_02230	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_02235	COG1408	metallophosphoesterase
A7K99_02250	COG1538	Outer membrane efflux protein
A7K99_02255	COG0456	acetyltransferase
A7K99_02260	COG0038	chloride channel
A7K99_02265	COG1560	Kdo2-lipid A biosynthetic process
A7K99_02285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7K99_02290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7K99_02295	COG2731	YhcH YjgK YiaL family protein
A7K99_02300	COG2271	Major facilitator Superfamily
A7K99_02310	COG0738	Major facilitator superfamily
A7K99_02315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7K99_02325	COG1609	Transcriptional regulator
A7K99_02330	COG2186	Transcriptional regulator
A7K99_02335	COG3734	2-keto-3-deoxy-galactonokinase
A7K99_02340	COG0800	Aldolase
A7K99_02355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7K99_02360	COG3385	transposase activity
A7K99_02365	COG1621	beta-fructofuranosidase activity
A7K99_02375	COG1621	beta-fructofuranosidase activity
A7K99_02385	COG3720	iron ion transport
A7K99_02390	COG4558	Periplasmic binding protein
A7K99_02395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7K99_02400	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A7K99_02410	COG0306	phosphate transporter
A7K99_02415	COG3550	peptidyl-serine autophosphorylation
A7K99_02420	COG3550	peptidyl-serine autophosphorylation
A7K99_02435	COG0673	inositol 2-dehydrogenase activity
A7K99_02445	COG0747	negative chemotaxis
A7K99_02450	COG0601	transmembrane transport
A7K99_02455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7K99_02465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_02505	COG4172	Belongs to the ABC transporter superfamily
A7K99_02510	COG1446	asparaginase
A7K99_02520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7K99_02525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7K99_02530	COG1349	DNA-binding transcription factor activity
A7K99_02555	COG2963	transposase activity
A7K99_02560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A7K99_02565	COG0235	Class ii aldolase
A7K99_02570	COG3623	hexulose-6-phosphate isomerase
A7K99_02575	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A7K99_02580	COG1070	Carbohydrate kinase
A7K99_02590	COG2731	YhcH YjgK YiaL family protein
A7K99_02600	COG1414	Transcriptional regulator
A7K99_02610	COG2211	Major facilitator Superfamily
A7K99_02625	COG0583	DNA-binding transcription factor activity
A7K99_02635	COG0431	NADPH-dependent FMN reductase
A7K99_02645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_02680	COG1802	Transcriptional regulator
A7K99_02690	COG0765	amino acid transport
A7K99_02700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_02705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7K99_02725	COG0586	Pfam SNARE associated Golgi protein
A7K99_02765	COG0791	NLP P60 protein
A7K99_02770	COG0402	S-adenosylhomocysteine deaminase activity
A7K99_02775	COG2188	Transcriptional regulator
A7K99_02785	COG2986	histidine ammonia-lyase
A7K99_02810	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A7K99_02815	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A7K99_02830	COG1063	alcohol dehydrogenase
A7K99_02835	COG2610	gluconate transmembrane transporter activity
A7K99_02840	COG2706	6-phosphogluconolactonase activity
A7K99_02880	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7K99_02895	COG3842	ATPase activity
A7K99_02900	COG0583	DNA-binding transcription factor activity
A7K99_02905	COG0129	dihydroxy-acid dehydratase activity
A7K99_02915	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_02930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7K99_02940	COG0531	amino acid
A7K99_02945	COG0697	spore germination
A7K99_02960	COG1984	allophanate hydrolase subunit 2
A7K99_02965	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A7K99_02990	COG4221	oxidoreductase activity
A7K99_03000	COG0765	amino acid transport
A7K99_03010	COG3318	Belongs to the UPF0149 family
A7K99_03010	COG3012	SEC-C Motif Domain Protein
A7K99_03020	COG4580	involved in the transport of maltose and maltodextrins
A7K99_03035	COG2182	Extracellular solute-binding protein
A7K99_03040	COG1175	transmembrane transport
A7K99_03045	COG3833	ABC-type maltose transport systems, permease component
A7K99_03065	COG1640	4-alpha-glucanotransferase
A7K99_03070	COG0058	SHG alpha-glucan phosphorylase activity
A7K99_03075	COG2909	trisaccharide binding
A7K99_03105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7K99_03110	COG0697	spore germination
A7K99_03115	COG2072	flavoprotein involved in K transport
A7K99_03130	COG1126	abc transporter atp-binding protein
A7K99_03145	COG3395	kinase activity
A7K99_03165	COG0235	Class ii aldolase
A7K99_03170	COG1349	DNA-binding transcription factor activity
A7K99_03175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A7K99_03180	COG0358	DNA primase activity
A7K99_03200	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A7K99_03210	COG0617	tRNA 3'-terminal CCA addition
A7K99_03215	COG4991	sh3 domain protein
A7K99_03220	COG3025	triphosphatase activity
A7K99_03245	COG3384	dioxygenase
A7K99_03250	COG0754	glutathionylspermidine amidase activity
A7K99_03265	COG0494	nUDIX hydrolase
A7K99_03270	COG3151	Protein conserved in bacteria
A7K99_03275	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A7K99_03280	COG3150	esterase
A7K99_03285	COG0187	DNA topoisomerase II activity
A7K99_03295	COG4771	TonB-dependent receptor
A7K99_03300	COG2819	hydrolase of the alpha beta superfamily
A7K99_03305	COG1396	sequence-specific DNA binding
A7K99_03325	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7K99_03340	COG0204	Acyl-transferase
A7K99_03345	COG2132	Multicopper oxidase
A7K99_03355	COG0656	L-ascorbic acid biosynthetic process
A7K99_03360	COG2207	Transcriptional regulator
A7K99_03365	COG0586	Pfam SNARE associated Golgi protein
A7K99_03370	COG0626	cystathionine gamma-synthase activity
A7K99_03375	COG0811	peptide transport
A7K99_03380	COG0848	biopolymer transport protein
A7K99_03395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7K99_03410	COG2308	Evidence 4 Homologs of previously reported genes of
A7K99_03420	COG1305	Transglutaminase-like
A7K99_03435	COG1528	Iron-storage protein
A7K99_03440	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A7K99_03445	COG2271	Major facilitator Superfamily
A7K99_03455	COG2823	Periplasmic or secreted lipoprotein
A7K99_03460	COG0084	hydrolase, TatD family'
A7K99_03470	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A7K99_03475	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A7K99_03495	COG0582	viral genome integration into host DNA
A7K99_03550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_03555	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_03565	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A7K99_03570	COG3622	Belongs to the hyi family
A7K99_03580	COG2837	iron assimilation
A7K99_03585	COG2822	iron ion transport
A7K99_03590	COG0672	)-iron permease
A7K99_03610	COG4993	Dehydrogenase
A7K99_03640	COG0765	amino acid transport
A7K99_03660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7K99_03675	COG1741	Belongs to the pirin family
A7K99_03685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A7K99_03705	COG0583	DNA-binding transcription factor activity
A7K99_03720	COG1902	pentaerythritol trinitrate reductase activity
A7K99_03730	COG4106	trans-aconitate 2-methyltransferase activity
A7K99_03745	COG0738	Major facilitator superfamily
A7K99_03760	COG1609	Transcriptional regulator
A7K99_03770	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_03780	COG1609	Transcriptional regulator
A7K99_03785	COG2181	nitrate reductase activity
A7K99_03790	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A7K99_03795	COG1140	nitrate reductase beta subunit
A7K99_03800	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A7K99_03805	COG2223	nitrite transmembrane transporter activity
A7K99_03810	COG2146	nitrite reductase [NAD(P)H] activity
A7K99_03815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7K99_03830	COG0702	epimerase
A7K99_03835	COG1733	regulation of RNA biosynthetic process
A7K99_03840	COG2375	cellular response to nickel ion
A7K99_03845	COG1695	Transcriptional regulator
A7K99_03855	COG0604	alcohol dehydrogenase
A7K99_03860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7K99_03870	COG1982	Orn Lys Arg decarboxylase major
A7K99_03875	COG0741	lytic transglycosylase activity
A7K99_03880	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A7K99_03885	COG1194	a g-specific adenine glycosylase
A7K99_03895	COG3171	Protein conserved in bacteria
A7K99_03905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7K99_03910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A7K99_03915	COG0762	integral membrane protein
A7K99_03920	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A7K99_03925	COG2805	Type II/IV secretion system protein
A7K99_03940	COG1678	Uncharacterized ACR, COG1678
A7K99_03950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A7K99_03960	COG2814	Major facilitator Superfamily
A7K99_03965	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A7K99_03975	COG1166	arginine decarboxylase activity
A7K99_03980	COG0010	Belongs to the arginase family
A7K99_03985	COG3753	Protein conserved in bacteria
A7K99_04005	COG1024	Enoyl-CoA hydratase
A7K99_04020	COG1473	amidohydrolase
A7K99_04030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A7K99_04040	COG0126	phosphoglycerate kinase activity
A7K99_04055	COG2084	Dehydrogenase
A7K99_04060	COG0668	transmembrane transport
A7K99_04065	COG1279	arginine transmembrane transporter activity
A7K99_04080	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A7K99_04085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7K99_04090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A7K99_04105	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A7K99_04115	COG0006	proline dipeptidase activity
A7K99_04120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7K99_04125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7K99_04130	COG1335	isochorismatase
A7K99_04140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_04160	COG0509	glycine decarboxylation via glycine cleavage system
A7K99_04175	COG1272	protein, Hemolysin III
A7K99_04180	COG0354	folic acid binding
A7K99_04185	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A7K99_04195	COG0716	FMN binding
A7K99_04200	COG4974	Belongs to the 'phage' integrase family
A7K99_04205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A7K99_04215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A7K99_04220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A7K99_04250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A7K99_04260	COG1088	dTDP-glucose 4,6-dehydratase activity
A7K99_04330	COG1482	cell wall glycoprotein biosynthetic process
A7K99_04335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7K99_04335	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_04340	COG3715	PTS system
A7K99_04345	COG3716	PTS system mannose fructose sorbose family IID component
A7K99_04360	COG1486	melibiose metabolic process
A7K99_04365	COG1447	Phosphotransferase system cellobiose-specific component IIA
A7K99_04370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7K99_04375	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A7K99_04380	COG2814	Major facilitator Superfamily
A7K99_04385	COG0583	DNA-binding transcription factor activity
A7K99_04395	COG0346	lactoylglutathione lyase activity
A7K99_04400	COG0019	diaminopimelate decarboxylase activity
A7K99_04410	COG0768	penicillin binding
A7K99_04420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7K99_04425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7K99_04440	COG0204	Acyl-transferase
A7K99_04440	COG0318	PFAM AMP-dependent synthetase and ligase
A7K99_04445	COG0477	Major facilitator Superfamily
A7K99_04450	COG0667	Aldo Keto reductase
A7K99_04460	COG0861	Integral membrane protein TerC family
A7K99_04470	COG1051	belongs to the nudix hydrolase family
A7K99_04475	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
A7K99_04480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A7K99_04510	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A7K99_04515	COG1074	ATP-dependent DNA helicase activity
A7K99_04520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7K99_04525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A7K99_04525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A7K99_04535	COG0531	amino acid
A7K99_04540	COG1982	Orn Lys Arg decarboxylase major
A7K99_04545	COG1438	arginine binding
A7K99_04575	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A7K99_04580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A7K99_04585	COG2166	iron-sulfur cluster assembly
A7K99_04590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7K99_04600	COG0583	DNA-binding transcription factor activity
A7K99_04605	COG2363	Small membrane protein
A7K99_04610	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A7K99_04620	COG1611	Belongs to the LOG family
A7K99_04635	COG3098	single-species biofilm formation
A7K99_04640	COG0564	pseudouridine synthase activity
A7K99_04645	COG0716	FMN binding
A7K99_04650	COG3437	response regulator, receiver
A7K99_04650	COG2205	protein histidine kinase activity
A7K99_04650	COG4999	Histidine kinase
A7K99_04650	COG3850	Histidine kinase
A7K99_04655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7K99_04660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A7K99_04665	COG3956	TIGRFAM MazG family protein
A7K99_04675	COG0504	CTP synthase activity
A7K99_04680	COG0148	phosphopyruvate hydratase activity
A7K99_04705	COG4964	Belongs to the GSP D family
A7K99_04760	COG0602	queuosine metabolic process
A7K99_04765	COG0720	synthase
A7K99_04770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A7K99_04775	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7K99_04780	COG0175	sulfate reduction
A7K99_04785	COG2234	aminopeptidase activity
A7K99_04790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7K99_04790	COG1648	precorrin-2 dehydrogenase activity
A7K99_04795	COG0175	sulfate reduction
A7K99_04815	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A7K99_04830	COG0585	pseudouridine synthase activity
A7K99_04835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A7K99_04845	COG4942	peptidase
A7K99_04845	COG1388	LysM domain
A7K99_04850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A7K99_04855	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A7K99_04865	COG2951	lytic endotransglycosylase activity
A7K99_04870	COG2824	Alkylphosphonate utilization operon protein PhnA
A7K99_04875	COG1546	Belongs to the CinA family
A7K99_04895	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A7K99_04935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7K99_04940	COG2918	glutathione biosynthetic process
A7K99_04945	COG1854	S-ribosylhomocysteine lyase activity
A7K99_04950	COG4536	flavin adenine dinucleotide binding
A7K99_04955	COG4137	Cytochrome C assembly protein
A7K99_04960	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A7K99_04965	COG0228	four-way junction DNA binding
A7K99_04980	COG0335	large ribosomal subunit rRNA binding
A7K99_04985	COG0531	amino acid
A7K99_05000	COG1064	alcohol dehydrogenase
A7K99_05005	COG2186	Transcriptional regulator
A7K99_05015	COG1764	response to oxidative stress
A7K99_05065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A7K99_05070	COG1671	Belongs to the UPF0178 family
A7K99_05075	COG3416	Protein conserved in bacteria
A7K99_05080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A7K99_05085	COG0765	amino acid transport
A7K99_05090	COG4597	amino acid ABC transporter
A7K99_05100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_05110	COG2974	May be involved in recombination
A7K99_05115	COG0531	amino acid
A7K99_05130	COG0419	ATPase involved in DNA repair
A7K99_05135	COG0420	3'-5' exonuclease activity
A7K99_05140	COG0745	RESPONSE REGULATOR receiver
A7K99_05145	COG5002	protein histidine kinase activity
A7K99_05150	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A7K99_05155	COG1114	Component of the transport system for branched-chain amino acids
A7K99_05165	COG0668	transmembrane transport
A7K99_05175	COG0450	alkyl hydroperoxide reductase
A7K99_05180	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
A7K99_05185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A7K99_05195	COG1862	Preprotein translocase
A7K99_05205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7K99_05210	COG3385	transposase activity
A7K99_05220	COG1652	LysM domain
A7K99_05230	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7K99_05230	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7K99_05235	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A7K99_05240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7K99_05245	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A7K99_05250	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A7K99_05255	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A7K99_05260	COG0142	geranyltranstransferase activity
A7K99_05265	COG1722	exodeoxyribonuclease VII activity
A7K99_05270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7K99_05270	COG0301	tRNA thio-modification
A7K99_05275	COG0693	protein deglycase activity
A7K99_05280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A7K99_05285	COG1666	GTP binding
A7K99_05290	COG2814	Major facilitator Superfamily
A7K99_05295	COG0109	protoheme IX farnesyltransferase activity
A7K99_05300	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A7K99_05305	COG1845	cytochrome c oxidase, subunit III
A7K99_05310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A7K99_05315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A7K99_05320	COG2223	nitrite transmembrane transporter activity
A7K99_05325	COG3056	Lipoprotein
A7K99_05330	COG0271	Belongs to the BolA IbaG family
A7K99_05340	COG0740	serine-type endopeptidase activity
A7K99_05350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7K99_05355	COG0776	regulation of translation
A7K99_05360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7K99_05365	COG1555	photosystem II stabilization
A7K99_05370	COG0824	Thioesterase
A7K99_05385	COG1522	sequence-specific DNA binding
A7K99_05390	COG1132	(ABC) transporter
A7K99_05395	COG1132	(ABC) transporter
A7K99_05400	COG0347	Belongs to the P(II) protein family
A7K99_05405	COG0004	ammonium transporteR
A7K99_05425	COG1946	Acyl-CoA thioesterase
A7K99_05430	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A7K99_05435	COG3695	enzyme binding
A7K99_05455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A7K99_05465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7K99_05470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7K99_05475	COG1309	transcriptional regulator
A7K99_05490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7K99_05500	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A7K99_05505	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A7K99_05510	COG0326	Molecular chaperone. Has ATPase activity
A7K99_05515	COG0563	adenylate kinase activity
A7K99_05520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A7K99_05525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7K99_05530	COG4651	solute:proton antiporter activity
A7K99_05530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A7K99_05545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A7K99_05550	COG3735	TraB family
A7K99_05555	COG2217	Heavy metal translocating P-type atpase
A7K99_05565	COG3118	belongs to the thioredoxin family
A7K99_05570	COG0300	oxidoreductase activity
A7K99_05575	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A7K99_05580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A7K99_05590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A7K99_05595	COG0215	cysteine-tRNA ligase activity
A7K99_05600	COG2501	S4 domain
A7K99_05615	COG3706	GGDEF domain
A7K99_05615	COG0745	RESPONSE REGULATOR receiver
A7K99_05645	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A7K99_05700	COG0583	DNA-binding transcription factor activity
A7K99_05705	COG0596	Alpha beta hydrolase
A7K99_05710	COG0745	RESPONSE REGULATOR receiver
A7K99_05715	COG2205	protein histidine kinase activity
A7K99_05755	COG2207	Transcriptional regulator
A7K99_05765	COG0432	Pfam Uncharacterised protein family UPF0047
A7K99_05770	COG2353	YceI-like domain
A7K99_05775	COG0110	maltose O-acetyltransferase activity
A7K99_05780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7K99_05810	COG1064	alcohol dehydrogenase
A7K99_05815	COG1733	regulation of RNA biosynthetic process
A7K99_05825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_05830	COG2272	Belongs to the type-B carboxylesterase lipase family
A7K99_05835	COG0667	Aldo Keto reductase
A7K99_05840	COG1742	UPF0060 membrane protein
A7K99_05845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7K99_05860	COG5285	phytanoyl-CoA dioxygenase
A7K99_05900	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A7K99_05910	COG1278	Cold shock
A7K99_05915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7K99_05920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A7K99_05925	COG0321	lipoyl(octanoyl) transferase activity
A7K99_05935	COG1686	Belongs to the peptidase S11 family
A7K99_05940	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A7K99_05945	COG0772	Belongs to the SEDS family
A7K99_05950	COG0768	penicillin binding
A7K99_05955	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A7K99_05960	COG0799	negative regulation of ribosome biogenesis
A7K99_05970	COG1466	dna polymerase III delta subunit
A7K99_05975	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A7K99_05980	COG0495	leucyl-tRNA aminoacylation
A7K99_05985	COG1126	abc transporter atp-binding protein
A7K99_05990	COG0765	amino acid transport
A7K99_05995	COG0765	amino acid transport
A7K99_06005	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A7K99_06010	COG4535	Mg2 and Co2 transporter CorC
A7K99_06020	COG1702	phosphate starvation-inducible protein PhoH
A7K99_06030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7K99_06035	COG3385	transposase activity
A7K99_06075	COG0367	asparagine synthase
A7K99_06085	COG0647	UMP catabolic process
A7K99_06090	COG1846	Transcriptional regulator
A7K99_06090	COG1940	carbohydrate kinase activity
A7K99_06095	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A7K99_06105	COG2190	(PTS) system
A7K99_06105	COG1263	PTS System
A7K99_06105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7K99_06130	COG0735	belongs to the Fur family
A7K99_06135	COG0716	FMN binding
A7K99_06145	COG0596	Alpha beta hydrolase
A7K99_06150	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A7K99_06155	COG0033	Phosphoglucomutase
A7K99_06160	COG3272	Protein of unknown function (DUF1722)
A7K99_06165	COG0415	Belongs to the DNA photolyase family
A7K99_06170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A7K99_06175	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A7K99_06180	COG1984	allophanate hydrolase subunit 2
A7K99_06190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7K99_06200	COG2009	succinate dehydrogenase
A7K99_06205	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A7K99_06210	COG1053	succinate dehydrogenase
A7K99_06215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A7K99_06220	COG0567	Dehydrogenase, E1 component
A7K99_06225	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7K99_06230	COG0045	succinate-CoA ligase (ADP-forming) activity
A7K99_06235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A7K99_06240	COG1271	oxidase subunit
A7K99_06245	COG1294	oxidase, subunit
A7K99_06250	COG3790	cyd operon protein YbgE
A7K99_06255	COG0824	Thioesterase
A7K99_06260	COG0811	peptide transport
A7K99_06265	COG0848	biopolymer transport protein
A7K99_06270	COG3064	Membrane
A7K99_06270	COG3064	Membrane
A7K99_06280	COG2885	chlorophyll binding
A7K99_06285	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A7K99_06325	COG2169	Transcriptional regulator
A7K99_06335	COG1230	cation diffusion facilitator family transporter
A7K99_06340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A7K99_06345	COG0588	phosphoglycerate mutase activity
A7K99_06350	COG2017	converts alpha-aldose to the beta-anomer
A7K99_06360	COG1085	galactose-1-phosphate uridylyltransferase
A7K99_06365	COG1119	ATPase activity
A7K99_06370	COG3585	molybdate ion transport
A7K99_06370	COG2005	Transcriptional regulator
A7K99_06375	COG0561	phosphatase activity
A7K99_06385	COG1881	PFAM PEBP family protein
A7K99_06395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A7K99_06410	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A7K99_06415	COG0410	ABC transporter
A7K99_06420	COG0556	nucleotide-excision repair
A7K99_06435	COG0521	Mo-molybdopterin cofactor biosynthetic process
A7K99_06440	COG0315	cyclic pyranopterin monophosphate synthase activity
A7K99_06445	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A7K99_06450	COG0314	molybdopterin synthase activity
A7K99_06460	COG0670	Belongs to the BI1 family
A7K99_06475	COG0513	Belongs to the DEAD box helicase family
A7K99_06480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7K99_06485	COG0477	Major facilitator Superfamily
A7K99_06490	COG1376	ErfK ybiS ycfS ynhG family protein
A7K99_06495	COG0586	Pfam SNARE associated Golgi protein
A7K99_06500	COG1686	Belongs to the peptidase S11 family
A7K99_06505	COG3264	Mechanosensitive ion channel
A7K99_06505	COG1511	domain protein
A7K99_06510	COG1472	Belongs to the glycosyl hydrolase 3 family
A7K99_06520	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A7K99_06530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7K99_06535	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A7K99_06540	COG0783	Belongs to the Dps family
A7K99_06545	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A7K99_06550	COG3385	transposase activity
A7K99_06575	COG1321	iron dependent repressor
A7K99_06580	COG2916	Histone family protein nucleoid-structuring protein H-NS
A7K99_06585	COG0488	(ABC) transporter
A7K99_06595	COG0303	'Molybdopterin
A7K99_06605	COG1686	Belongs to the peptidase S11 family
A7K99_06610	COG0671	phosphoesterase, PA-phosphatase related
A7K99_06615	COG0569	domain protein
A7K99_06615	COG2985	domain, Protein
A7K99_06620	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A7K99_06630	COG0778	Nitroreductase
A7K99_06640	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A7K99_06645	COG3842	ATPase activity
A7K99_06650	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7K99_06655	COG1177	transmembrane transport
A7K99_06665	COG4160	amino acid transport
A7K99_06670	COG4215	(ABC) transporter
A7K99_06675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_06680	COG1126	abc transporter atp-binding protein
A7K99_06685	COG3023	N-Acetylmuramoyl-L-alanine amidase
A7K99_06690	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A7K99_06695	COG0028	Belongs to the TPP enzyme family
A7K99_06700	COG3593	DNA synthesis involved in DNA repair
A7K99_06705	COG1278	Cold shock
A7K99_06710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A7K99_06715	COG0542	response to heat
A7K99_06720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A7K99_06725	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A7K99_06730	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A7K99_06735	COG4988	ABC transporter
A7K99_06740	COG0492	ferredoxin-NADP+ reductase activity
A7K99_06750	COG3107	peptidoglycan biosynthetic process
A7K99_06750	COG1674	ftsk spoiiie
A7K99_06760	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A7K99_06795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A7K99_06800	COG1882	Formate acetyltransferase
A7K99_06805	COG2116	formate transmembrane transporter activity
A7K99_06810	COG1944	ATP diphosphatase activity
A7K99_06815	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A7K99_06825	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A7K99_06830	COG0539	negative regulation of cytoplasmic translation
A7K99_06840	COG0658	competence protein
A7K99_06840	COG2333	competence protein COMEC
A7K99_06865	COG3173	Aminoglycoside phosphotransferase
A7K99_06870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A7K99_06875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7K99_06880	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
A7K99_06885	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A7K99_06895	COG2989	Protein conserved in bacteria
A7K99_06900	COG3108	Peptidase M15
A7K99_06905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7K99_06910	COG1448	Aminotransferase
A7K99_06920	COG0017	Asparaginyl-tRNA synthetase
A7K99_06930	COG0308	aminopeptidase N
A7K99_06935	COG0167	dihydroorotate dehydrogenase activity
A7K99_06945	COG0633	Ferredoxin
A7K99_06945	COG3217	Mosc domain protein beta barrel domain protein
A7K99_06950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7K99_06950	COG0116	Belongs to the methyltransferase superfamily
A7K99_06955	COG0488	(ABC) transporter
A7K99_06960	COG2995	paraquat-inducible protein a
A7K99_06965	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A7K99_06965	COG3008	intermembrane lipid transfer
A7K99_06970	COG3009	Protein conserved in bacteria
A7K99_06980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7K99_06985	COG1067	ATP-dependent peptidase activity
A7K99_06990	COG3120	sequence-specific DNA binding
A7K99_07005	COG3070	regulator of competence-specific genes
A7K99_07010	COG1289	transmembrane transporter activity
A7K99_07015	COG3304	Inner membrane component domain
A7K99_07020	COG0210	DNA helicase
A7K99_07025	COG1803	Methylglyoxal synthase
A7K99_07030	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
A7K99_07035	COG1832	CoA-binding protein
A7K99_07045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7K99_07060	COG0670	Belongs to the BI1 family
A7K99_07080	COG1113	amino acid transport
A7K99_07090	COG2197	response regulator
A7K99_07100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A7K99_07110	COG0583	DNA-binding transcription factor activity
A7K99_07135	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
A7K99_07165	COG1309	transcriptional regulator
A7K99_07175	COG1349	DNA-binding transcription factor activity
A7K99_07190	COG0154	amidase activity
A7K99_07230	COG1464	Belongs to the NlpA lipoprotein family
A7K99_07245	COG1566	PFAM secretion protein HlyD family protein
A7K99_07260	COG1454	alcohol dehydrogenase
A7K99_07265	COG0656	L-ascorbic acid biosynthetic process
A7K99_07280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_07285	COG1289	transmembrane transporter activity
A7K99_07305	COG1953	Uracil, thiamine, allantoin
A7K99_07315	COG0477	Major facilitator Superfamily
A7K99_07320	COG2814	Major facilitator Superfamily
A7K99_07350	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A7K99_07365	COG0659	secondary active sulfate transmembrane transporter activity
A7K99_07380	COG2943	transferase activity, transferring hexosyl groups
A7K99_07385	COG5645	(Lipo)protein
A7K99_07395	COG1560	Kdo2-lipid A biosynthetic process
A7K99_07425	COG0418	dihydroorotase activity
A7K99_07435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7K99_07460	COG1815	bacterial-type flagellum-dependent cell motility
A7K99_07465	COG1558	bacterial-type flagellum-dependent cell motility
A7K99_07470	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A7K99_07475	COG1749	Flagellar hook protein flgE
A7K99_07480	COG4787	bacterial-type flagellum-dependent cell motility
A7K99_07485	COG4786	Flagellar basal body rod
A7K99_07505	COG1256	bacterial-type flagellum assembly
A7K99_07515	COG1530	ribonuclease E activity
A7K99_07520	COG0564	pseudouridine synthase activity
A7K99_07525	COG0366	Alpha amylase catalytic
A7K99_07535	COG1399	metal-binding, possibly nucleic acid-binding protein
A7K99_07540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A7K99_07550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7K99_07560	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_07565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7K99_07570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7K99_07575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A7K99_07585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7K99_07590	COG0470	DNA polymerase III
A7K99_07595	COG0084	hydrolase, TatD family'
A7K99_07600	COG0537	adenosine 5'-monophosphoramidase activity
A7K99_07605	COG5633	Lipoprotein
A7K99_07610	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
A7K99_07615	COG0510	thiamine kinase activity
A7K99_07625	COG1252	NADH dehydrogenase
A7K99_07630	COG3134	Outer membrane lipoprotein
A7K99_07635	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A7K99_07640	COG4591	ABC-type transport system involved in lipoprotein release permease component
A7K99_07650	COG4591	ABC-type transport system involved in lipoprotein release permease component
A7K99_07655	COG1116	anion transmembrane transporter activity
A7K99_07660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_07670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_07680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A7K99_07685	COG0500	methyltransferase
A7K99_07690	COG3842	ATPase activity
A7K99_07700	COG2850	peptidyl-arginine hydroxylation
A7K99_07710	COG0745	RESPONSE REGULATOR receiver
A7K99_07715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A7K99_07720	COG2915	High frequency lysogenization protein hflD homolog
A7K99_07735	COG1187	pseudouridine synthase activity
A7K99_07740	COG0538	isocitrate dehydrogenase activity
A7K99_07765	COG1902	pentaerythritol trinitrate reductase activity
A7K99_07790	COG0583	DNA-binding transcription factor activity
A7K99_07815	COG1794	racemase activity, acting on amino acids and derivatives
A7K99_07820	COG0583	DNA-binding transcription factor activity
A7K99_07850	COG3122	Protein conserved in bacteria
A7K99_07860	COG1683	Conserved Protein
A7K99_07890	COG1619	proteins homologs of microcin C7 resistance protein MccF
A7K99_07900	COG2261	transglycosylase associated protein
A7K99_07910	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A7K99_07915	COG3381	protein complex oligomerization
A7K99_07930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_07940	COG0814	amino acid
A7K99_07950	COG1918	ferrous iron import across plasma membrane
A7K99_07960	COG4574	serine-type endopeptidase inhibitor activity
A7K99_07970	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7K99_07975	COG4533	DNA binding
A7K99_07995	COG0754	glutathionylspermidine amidase activity
A7K99_08000	COG0028	Belongs to the TPP enzyme family
A7K99_08005	COG0679	Auxin Efflux Carrier
A7K99_08010	COG0484	heat shock protein binding
A7K99_08040	COG0583	DNA-binding transcription factor activity
A7K99_08055	COG0411	ABC transporter
A7K99_08095	COG0456	acetyltransferase
A7K99_08100	COG0318	PFAM AMP-dependent synthetase and ligase
A7K99_08110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7K99_08115	COG0156	8-amino-7-oxononanoate synthase activity
A7K99_08120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7K99_08125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7K99_08130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7K99_08135	COG2244	polysaccharide biosynthetic process
A7K99_08145	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A7K99_08150	COG0795	lipopolysaccharide-transporting ATPase activity
A7K99_08165	COG0656	L-ascorbic acid biosynthetic process
A7K99_08190	COG1881	PFAM PEBP family protein
A7K99_08195	COG1942	4-Oxalocrotonate Tautomerase
A7K99_08200	COG4221	oxidoreductase activity
A7K99_08205	COG2010	Cytochrome c
A7K99_08230	COG0477	Major facilitator Superfamily
A7K99_08235	COG1309	transcriptional regulator
A7K99_08240	COG0789	Transcriptional regulator
A7K99_08245	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A7K99_08250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7K99_08270	COG0456	acetyltransferase
A7K99_08275	COG0702	epimerase
A7K99_08285	COG4221	oxidoreductase activity
A7K99_08290	COG0667	Aldo Keto reductase
A7K99_08295	COG0656	L-ascorbic acid biosynthetic process
A7K99_08320	COG0012	GTP binding
A7K99_08340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A7K99_08345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A7K99_08350	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A7K99_08360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A7K99_08365	COG2890	protein-(glutamine-N5) methyltransferase activity
A7K99_08370	COG3094	Invasion gene expression up-regulator, SirB
A7K99_08375	COG2912	Transglutaminase-like superfamily
A7K99_08395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7K99_08405	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_08410	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7K99_08415	COG0765	amino acid transport
A7K99_08420	COG0765	amino acid transport
A7K99_08425	COG1126	abc transporter atp-binding protein
A7K99_08430	COG0583	DNA-binding transcription factor activity
A7K99_08435	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_08445	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7K99_08450	COG0387	Pfam Sodium calcium exchanger
A7K99_08455	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A7K99_08460	COG4932	domain protein
A7K99_08470	COG3138	arginine N-succinyltransferase
A7K99_08475	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_08485	COG2988	succinylglutamate desuccinylase activity
A7K99_08490	COG3678	ATP-independent chaperone mediated protein folding
A7K99_08495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A7K99_08500	COG2814	Major facilitator Superfamily
A7K99_08505	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7K99_08515	COG1988	membrane-bound metal-dependent
A7K99_08520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7K99_08535	COG3137	Salt-induced outer membrane protein
A7K99_08545	COG1802	Transcriptional regulator
A7K99_08555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A7K99_08565	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A7K99_08570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A7K99_08585	COG0776	regulation of translation
A7K99_08590	COG0791	NLP P60 protein
A7K99_08595	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A7K99_08600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A7K99_08605	COG0628	permease
A7K99_08610	COG0277	FAD linked oxidase domain protein
A7K99_08610	COG0247	lactate metabolic process
A7K99_08620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_08625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_08635	COG3385	transposase activity
A7K99_08645	COG0366	Alpha amylase catalytic
A7K99_08650	COG1263	PTS System
A7K99_08650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7K99_08655	COG1609	Transcriptional regulator
A7K99_08680	COG0307	riboflavin synthase, alpha
A7K99_08685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A7K99_08690	COG2814	Major facilitator Superfamily
A7K99_08695	COG0583	DNA-binding transcription factor activity
A7K99_08700	COG1609	Transcriptional regulator
A7K99_08705	COG0791	NLP P60 protein
A7K99_08710	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A7K99_08720	COG0346	lactoylglutathione lyase activity
A7K99_08725	COG1902	pentaerythritol trinitrate reductase activity
A7K99_08735	COG1566	PFAM secretion protein HlyD family protein
A7K99_08750	COG3133	Outer membrane lipoprotein
A7K99_08770	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A7K99_08790	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_08795	COG0583	DNA-binding transcription factor activity
A7K99_08805	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A7K99_08810	COG4660	Part of a membrane complex involved in electron transport
A7K99_08815	COG4659	FMN binding
A7K99_08820	COG4658	electron transport chain
A7K99_08830	COG2878	Part of a membrane complex involved in electron transport
A7K99_08835	COG4657	Part of a membrane complex involved in electron transport
A7K99_08840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A7K99_08850	COG5339	Protein conserved in bacteria
A7K99_08875	COG2207	Transcriptional regulator
A7K99_08875	COG3708	Transcriptional regulator
A7K99_08905	COG3135	benzoate transporter
A7K99_08910	COG1396	sequence-specific DNA binding
A7K99_08915	COG1335	isochorismatase
A7K99_08920	COG3180	Ammonia monooxygenase
A7K99_08925	COG4772	TonB-dependent receptor
A7K99_08955	COG0535	radical SAM domain protein
A7K99_08965	COG0277	FAD linked oxidase domain protein
A7K99_08975	COG2860	membrane
A7K99_08985	COG0625	glutathione transferase activity
A7K99_08995	COG3842	ATPase activity
A7K99_09005	COG1175	transmembrane transport
A7K99_09025	COG0642	Histidine kinase
A7K99_09030	COG0745	RESPONSE REGULATOR receiver
A7K99_09040	COG3727	T/G mismatch-specific endonuclease activity
A7K99_09055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7K99_09060	COG0656	L-ascorbic acid biosynthetic process
A7K99_09070	COG3781	membrane
A7K99_09080	COG3659	wide pore channel activity
A7K99_09085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7K99_09090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7K99_09095	COG1120	ATPase activity
A7K99_09110	COG4615	Cyclic peptide transporter
A7K99_09140	COG1473	amidohydrolase
A7K99_09145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_09155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7K99_09165	COG2130	NADP-dependent
A7K99_09170	COG1309	transcriptional regulator
A7K99_09185	COG0583	DNA-binding transcription factor activity
A7K99_09205	COG0435	Glutathione S-transferase
A7K99_09210	COG0400	carboxylic ester hydrolase activity
A7K99_09235	COG3414	Phosphotransferase system galactitol-specific IIB component
A7K99_09255	COG2233	PERMEase
A7K99_09260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7K99_09270	COG0251	oxidation-reduction process
A7K99_09280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_09285	COG1309	transcriptional regulator
A7K99_09295	COG0778	Nitroreductase
A7K99_09305	COG0583	DNA-binding transcription factor activity
A7K99_09320	COG0519	Catalyzes the synthesis of GMP from XMP
A7K99_09325	COG2814	Major facilitator Superfamily
A7K99_09365	COG0024	Methionine aminopeptidase
A7K99_09370	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7K99_09380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_09390	COG2271	Major facilitator Superfamily
A7K99_09410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7K99_09415	COG1414	Transcriptional regulator
A7K99_09440	COG0477	Major facilitator Superfamily
A7K99_09450	COG0583	DNA-binding transcription factor activity
A7K99_09460	COG1942	4-Oxalocrotonate Tautomerase
A7K99_09470	COG0583	DNA-binding transcription factor activity
A7K99_09490	COG3385	transposase activity
A7K99_09495	COG2010	Cytochrome c
A7K99_09520	COG0318	PFAM AMP-dependent synthetase and ligase
A7K99_09525	COG0183	Belongs to the thiolase family
A7K99_09555	COG3622	Belongs to the hyi family
A7K99_09565	COG2267	carboxylic ester hydrolase activity
A7K99_09585	COG2267	carboxylic ester hydrolase activity
A7K99_09595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_09615	COG1063	alcohol dehydrogenase
A7K99_09620	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_09635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7K99_09640	COG0076	glutamate decarboxylase activity
A7K99_09660	COG1538	Outer membrane efflux protein
A7K99_09665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7K99_09670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7K99_09690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7K99_09695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7K99_09700	COG0583	DNA-binding transcription factor activity
A7K99_09705	COG3479	Phenolic acid decarboxylase
A7K99_09710	COG3385	transposase activity
A7K99_09735	COG3842	ATPase activity
A7K99_09750	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A7K99_09755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7K99_09760	COG0583	DNA-binding transcription factor activity
A7K99_09770	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7K99_09775	COG1177	transmembrane transport
A7K99_09780	COG2072	flavoprotein involved in K transport
A7K99_09785	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A7K99_09795	COG1309	transcriptional regulator
A7K99_09800	COG3177	Filamentation induced by cAMP protein fic
A7K99_09820	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7K99_09825	COG0667	Aldo Keto reductase
A7K99_09830	COG2068	MobA-Related Protein
A7K99_09835	COG1335	isochorismatase
A7K99_09840	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A7K99_09845	COG0154	amidase activity
A7K99_09850	COG0583	DNA-binding transcription factor activity
A7K99_09855	COG0667	Aldo Keto reductase
A7K99_09870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A7K99_09875	COG1451	nucleotide metabolic process
A7K99_09885	COG2706	6-phosphogluconolactonase activity
A7K99_09900	COG1309	transcriptional regulator
A7K99_09910	COG0402	S-adenosylhomocysteine deaminase activity
A7K99_09915	COG4221	oxidoreductase activity
A7K99_09935	COG1940	carbohydrate kinase activity
A7K99_09940	COG0583	DNA-binding transcription factor activity
A7K99_09945	COG2814	Major facilitator Superfamily
A7K99_09950	COG3038	cytochrome b561
A7K99_09960	COG3422	double-strand break repair
A7K99_09965	COG0583	DNA-binding transcription factor activity
A7K99_09970	COG2840	Smr protein MutS2
A7K99_09975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7K99_09990	COG0531	amino acid
A7K99_10000	COG0745	RESPONSE REGULATOR receiver
A7K99_10005	COG2205	protein histidine kinase activity
A7K99_10020	COG3591	Belongs to the peptidase S1B family
A7K99_10025	COG1643	Atp-dependent helicase
A7K99_10040	COG2911	Protein conserved in bacteria
A7K99_10045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7K99_10065	COG4166	transmembrane transport
A7K99_10070	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A7K99_10080	COG3768	UPF0283 membrane protein
A7K99_10085	COG3106	COG3106 Predicted ATPase
A7K99_10095	COG1983	PspC domain protein
A7K99_10105	COG1842	Phage shock protein A
A7K99_10110	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A7K99_10115	COG4166	transmembrane transport
A7K99_10120	COG4168	peptide transport system, permease
A7K99_10125	COG4171	peptide transport system, permease
A7K99_10140	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A7K99_10150	COG0583	DNA-binding transcription factor activity
A7K99_10160	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
A7K99_10170	COG0023	Translation Initiation Factor
A7K99_10180	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A7K99_10185	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A7K99_10190	COG0671	phosphoesterase, PA-phosphatase related
A7K99_10200	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A7K99_10210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A7K99_10225	COG0616	signal peptide processing
A7K99_10230	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_10240	COG0009	L-threonylcarbamoyladenylate synthase
A7K99_10245	COG0613	PHP domain protein
A7K99_10255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7K99_10255	COG0512	Glutamine amidotransferase of anthranilate synthase
A7K99_10260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7K99_10275	COG0159	tryptophan synthase activity
A7K99_10285	COG3047	cAMP biosynthetic process
A7K99_10295	COG2917	probably involved in intracellular septation
A7K99_10300	COG1607	acyl-coa hydrolase
A7K99_10310	COG2350	Protein conserved in bacteria
A7K99_10330	COG3099	Belongs to the UPF0263 family
A7K99_10335	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_10335	COG1454	alcohol dehydrogenase
A7K99_10350	COG1435	thymidine kinase activity
A7K99_10365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A7K99_10370	COG0745	RESPONSE REGULATOR receiver
A7K99_10380	COG0788	formyltetrahydrofolate deformylase activity
A7K99_10410	COG0708	Exodeoxyribonuclease III
A7K99_10420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A7K99_10425	COG0778	Nitroreductase
A7K99_10430	COG0616	signal peptide processing
A7K99_10435	COG0252	asparaginase activity
A7K99_10440	COG3139	Protein of unknown function (DUF1315)
A7K99_10465	COG3713	MltA-interacting MipA family protein
A7K99_10475	COG2766	serine protein kinase
A7K99_10480	COG2718	Belongs to the UPF0229 family
A7K99_10500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A7K99_10505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7K99_10510	COG2719	SpoVR family
A7K99_10530	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7K99_10535	COG3100	YcgL domain-containing protein
A7K99_10540	COG0850	regulation of cytokinetic process
A7K99_10545	COG2894	cell division
A7K99_10550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A7K99_10555	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A7K99_10560	COG0318	PFAM AMP-dependent synthetase and ligase
A7K99_10565	COG3065	identical protein binding
A7K99_10575	COG1199	ATP-dependent helicase activity
A7K99_10580	COG0251	oxidation-reduction process
A7K99_10600	COG1760	l-serine dehydratase
A7K99_10605	COG1253	flavin adenine dinucleotide binding
A7K99_10610	COG2226	methyltransferase
A7K99_10615	COG1278	Cold shock
A7K99_10635	COG0501	Belongs to the peptidase M48B family
A7K99_10645	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A7K99_10650	COG1956	GAF domain-containing protein
A7K99_10655	COG2995	paraquat-inducible protein a
A7K99_10660	COG3008	intermembrane lipid transfer
A7K99_10665	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A7K99_10665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A7K99_10675	COG1276	copper resistance
A7K99_10685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7K99_10690	COG1770	oligopeptidase
A7K99_10695	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A7K99_10710	COG0583	DNA-binding transcription factor activity
A7K99_10715	COG4774	siderophore transport
A7K99_10725	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A7K99_10730	COG0469	pyruvate kinase activity
A7K99_10735	COG1560	Kdo2-lipid A biosynthetic process
A7K99_10740	COG0739	heme binding
A7K99_10745	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A7K99_10750	COG1121	(ABC) transporter
A7K99_10755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7K99_10760	COG2255	four-way junction helicase activity
A7K99_10765	COG0632	four-way junction helicase activity
A7K99_10775	COG0217	transcriptional regulatory protein
A7K99_10780	COG0494	nUDIX hydrolase
A7K99_10785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A7K99_10790	COG1801	Protein of unknown function DUF72
A7K99_10800	COG0500	methyltransferase
A7K99_10805	COG3142	Participates in the control of copper homeostasis
A7K99_10810	COG3102	Protein conserved in bacteria
A7K99_10825	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A7K99_10835	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A7K99_10840	COG0745	RESPONSE REGULATOR receiver
A7K99_10850	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A7K99_10860	COG0835	chemotaxis
A7K99_10865	COG0643	Histidine kinase
A7K99_10865	COG2198	Histidine kinase
A7K99_10870	COG1360	Flagellar Motor Protein
A7K99_10905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7K99_10925	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7K99_10935	COG3069	C4-dicarboxylate transmembrane transporter activity
A7K99_10945	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A7K99_10965	COG1702	phosphate starvation-inducible protein PhoH
A7K99_10970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7K99_10975	COG0506	proline dehydrogenase activity
A7K99_10975	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A7K99_10975	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A7K99_10990	COG0583	DNA-binding transcription factor activity
A7K99_11000	COG1191	sigma factor activity
A7K99_11025	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A7K99_11050	COG2207	Transcriptional regulator
A7K99_11055	COG2113	Glycine betaine
A7K99_11070	COG1677	Flagellar hook-basal body complex protein FliE
A7K99_11080	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A7K99_11085	COG1317	bacterial-type flagellum organization
A7K99_11090	COG1157	protein secretion by the type III secretion system
A7K99_11105	COG1580	Controls the rotational direction of flagella during chemotaxis
A7K99_11120	COG3190	flagellar
A7K99_11125	COG1338	Plays a role in the flagellum-specific transport system
A7K99_11135	COG1684	flagellar biosynthetic protein fliR
A7K99_11150	COG2354	Protein conserved in bacteria
A7K99_11160	COG1418	mRNA catabolic process
A7K99_11165	COG0477	Major facilitator Superfamily
A7K99_11175	COG1121	(ABC) transporter
A7K99_11190	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A7K99_11200	COG3384	dioxygenase
A7K99_11210	COG0583	DNA-binding transcription factor activity
A7K99_11220	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A7K99_11225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A7K99_11230	COG2828	Protein conserved in bacteria
A7K99_11270	COG1959	2 iron, 2 sulfur cluster binding
A7K99_11285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7K99_11290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7K99_11295	COG0583	DNA-binding transcription factor activity
A7K99_11300	COG0640	Transcriptional regulator
A7K99_11315	COG2814	Major facilitator Superfamily
A7K99_11320	COG0583	DNA-binding transcription factor activity
A7K99_11340	COG0477	Major facilitator Superfamily
A7K99_11345	COG2186	Transcriptional regulator
A7K99_11365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7K99_11365	COG0189	ligase activity
A7K99_11370	COG1902	pentaerythritol trinitrate reductase activity
A7K99_11375	COG3684	Belongs to the aldolase LacD family
A7K99_11390	COG1349	DNA-binding transcription factor activity
A7K99_11395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7K99_11410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7K99_11440	COG0583	DNA-binding transcription factor activity
A7K99_11455	COG1902	pentaerythritol trinitrate reductase activity
A7K99_11460	COG0596	Alpha beta hydrolase
A7K99_11505	COG0583	DNA-binding transcription factor activity
A7K99_11510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A7K99_11515	COG2851	Citrate transporter
A7K99_11525	COG1174	glycine betaine transport
A7K99_11530	COG1174	glycine betaine transport
A7K99_11565	COG2814	Major facilitator Superfamily
A7K99_11580	COG4773	Receptor
A7K99_11585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_11590	COG2814	Major facilitator Superfamily
A7K99_11600	COG0656	L-ascorbic acid biosynthetic process
A7K99_11635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_11645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_11665	COG1881	PFAM PEBP family protein
A7K99_11720	COG0656	L-ascorbic acid biosynthetic process
A7K99_11725	COG0656	L-ascorbic acid biosynthetic process
A7K99_11745	COG1064	alcohol dehydrogenase
A7K99_11750	COG0656	L-ascorbic acid biosynthetic process
A7K99_11790	COG2223	nitrite transmembrane transporter activity
A7K99_11800	COG4221	oxidoreductase activity
A7K99_11805	COG0477	Major facilitator Superfamily
A7K99_11825	COG0583	DNA-binding transcription factor activity
A7K99_11850	COG1403	HNH endonuclease
A7K99_11865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7K99_11870	COG1454	alcohol dehydrogenase
A7K99_11875	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_11890	COG2199	diguanylate cyclase activity
A7K99_11890	COG2203	Gaf domain
A7K99_11910	COG4977	sequence-specific DNA binding
A7K99_11925	COG2207	Transcriptional regulator
A7K99_11935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7K99_11935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_11935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_11940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7K99_11945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7K99_11950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7K99_11975	COG0243	molybdopterin cofactor binding
A7K99_11980	COG3189	MarR family transcriptional regulator
A7K99_11990	COG0765	amino acid transport
A7K99_11995	COG1126	abc transporter atp-binding protein
A7K99_12000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_12010	COG0583	DNA-binding transcription factor activity
A7K99_12015	COG2116	formate transmembrane transporter activity
A7K99_12020	COG0625	glutathione transferase activity
A7K99_12025	COG2188	Transcriptional regulator
A7K99_12030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7K99_12035	COG1397	ADP-ribosylglycohydrolase
A7K99_12040	COG2211	Major facilitator Superfamily
A7K99_12045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A7K99_12045	COG2010	Cytochrome c
A7K99_12050	COG2080	2 iron, 2 sulfur cluster binding
A7K99_12055	COG1846	Transcriptional regulator
A7K99_12060	COG2271	Major facilitator Superfamily
A7K99_12065	COG2233	PERMEase
A7K99_12070	COG1335	isochorismatase
A7K99_12075	COG3473	Maleate cis-trans isomerase
A7K99_12080	COG0596	Alpha beta hydrolase
A7K99_12085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7K99_12090	COG2309	aminopeptidase activity
A7K99_12095	COG3608	succinylglutamate desuccinylase aspartoacylase
A7K99_12095	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A7K99_12100	COG0523	cobalamin synthesis protein
A7K99_12105	COG3300	MHYT domain
A7K99_12105	COG5001	Diguanylate cyclase
A7K99_12110	COG0534	Mate efflux family protein
A7K99_12115	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7K99_12120	COG2252	PERMEase
A7K99_12140	COG0765	amino acid transport
A7K99_12145	COG1126	abc transporter atp-binding protein
A7K99_12170	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
A7K99_12175	COG0583	DNA-binding transcription factor activity
A7K99_12190	COG0251	oxidation-reduction process
A7K99_12205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_12210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_12230	COG0371	Dehydrogenase
A7K99_12250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_12260	COG0765	amino acid transport
A7K99_12265	COG0165	Argininosuccinate lyase
A7K99_12275	COG1802	Transcriptional regulator
A7K99_12300	COG2814	Major facilitator Superfamily
A7K99_12310	COG2072	flavoprotein involved in K transport
A7K99_12320	COG2144	transferase activity, transferring acyl groups
A7K99_12345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7K99_12350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7K99_12355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7K99_12375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7K99_12380	COG1045	serine acetyltransferase
A7K99_12385	COG1116	anion transmembrane transporter activity
A7K99_12390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_12415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_12420	COG4771	TonB-dependent receptor
A7K99_12455	COG1070	Carbohydrate kinase
A7K99_12460	COG0583	DNA-binding transcription factor activity
A7K99_12470	COG4773	Receptor
A7K99_12480	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_12505	COG0667	Aldo Keto reductase
A7K99_12520	COG0583	DNA-binding transcription factor activity
A7K99_12525	COG0477	Major facilitator Superfamily
A7K99_12545	COG1120	ATPase activity
A7K99_12550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7K99_12555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7K99_12560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7K99_12595	COG1414	Transcriptional regulator
A7K99_12615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7K99_12620	COG2211	Major facilitator Superfamily
A7K99_12625	COG3940	Belongs to the glycosyl hydrolase 43 family
A7K99_12630	COG2271	Major facilitator Superfamily
A7K99_12650	COG0390	transport system, permease component
A7K99_12655	COG4619	ABC transporter
A7K99_12660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A7K99_12665	COG2926	Belongs to the UPF0265 family
A7K99_12670	COG1289	transmembrane transporter activity
A7K99_12685	COG0640	Transcriptional regulator
A7K99_12835	COG3728	DNA packaging
A7K99_12855	COG3772	lysozyme
A7K99_12865	COG0484	heat shock protein binding
A7K99_12965	COG4712	double-strand break repair protein
A7K99_13025	COG0582	viral genome integration into host DNA
A7K99_13030	COG2925	Exonuclease
A7K99_13035	COG0531	amino acid
A7K99_13040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7K99_13045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A7K99_13055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7K99_13060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A7K99_13060	COG0131	Imidazoleglycerol-phosphate dehydratase
A7K99_13065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A7K99_13070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A7K99_13080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A7K99_13080	COG0140	phosphoribosyl-ATP diphosphatase activity
A7K99_13090	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7K99_13100	COG2190	(PTS) system
A7K99_13100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7K99_13100	COG1263	PTS System
A7K99_13105	COG2723	6-phospho-beta-galactosidase activity
A7K99_13120	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A7K99_13185	COG2982	Protein involved in outer membrane biogenesis
A7K99_13205	COG0443	Heat shock 70 kDa protein
A7K99_13210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7K99_13220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7K99_13230	COG2205	protein histidine kinase activity
A7K99_13235	COG0745	RESPONSE REGULATOR receiver
A7K99_13245	COG1597	lipid kinase activity
A7K99_13250	COG0351	phosphomethylpyrimidine kinase
A7K99_13265	COG0513	Belongs to the DEAD box helicase family
A7K99_13285	COG3634	alkyl hydroperoxide reductase activity
A7K99_13290	COG0450	alkyl hydroperoxide reductase
A7K99_13300	COG0489	protein tyrosine kinase activity
A7K99_13305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7K99_13305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7K99_13310	COG0295	cytidine deaminase activity
A7K99_13315	COG0281	malic enzyme
A7K99_13340	COG2311	Membrane
A7K99_13350	COG0583	DNA-binding transcription factor activity
A7K99_13360	COG0833	amino acid
A7K99_13365	COG0583	DNA-binding transcription factor activity
A7K99_13370	COG2855	membrane
A7K99_13380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7K99_13380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7K99_13380	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A7K99_13385	COG1105	Belongs to the carbohydrate kinase PfkB family
A7K99_13390	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_13390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7K99_13400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A7K99_13405	COG0671	phosphoesterase, PA-phosphatase related
A7K99_13410	COG3385	transposase activity
A7K99_13415	COG0531	amino acid
A7K99_13425	COG0791	NLP P60 protein
A7K99_13435	COG2814	Major facilitator Superfamily
A7K99_13440	COG1187	pseudouridine synthase activity
A7K99_13445	COG1061	Type III restriction enzyme res subunit
A7K99_13450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A7K99_13460	COG3082	Protein of unknown function (DUF1414)
A7K99_13465	COG3083	sulfuric ester hydrolase activity
A7K99_13480	COG3619	membrane
A7K99_13485	COG2259	Doxx family
A7K99_13490	COG0583	DNA-binding transcription factor activity
A7K99_13520	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A7K99_13530	COG2198	Histidine kinase
A7K99_13530	COG0642	Histidine kinase
A7K99_13535	COG2197	response regulator
A7K99_13540	COG2205	protein histidine kinase activity
A7K99_13540	COG0784	Response regulator, receiver
A7K99_13550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7K99_13555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7K99_13565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7K99_13590	COG2153	protein acetylation
A7K99_13595	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_13605	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7K99_13610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A7K99_13615	COG0713	ATP synthesis coupled electron transport
A7K99_13620	COG0839	Belongs to the complex I subunit 6 family
A7K99_13630	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A7K99_13635	COG1034	ATP synthesis coupled electron transport
A7K99_13640	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A7K99_13645	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A7K99_13650	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7K99_13650	COG0649	NAD binding
A7K99_13665	COG0583	DNA-binding transcription factor activity
A7K99_13670	COG0436	Aminotransferase
A7K99_13675	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A7K99_13680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7K99_13685	COG3092	negative regulation of chromosome organization
A7K99_13695	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A7K99_13700	COG0280	phosphate acetyltransferase
A7K99_13700	COG0857	belongs to the CobB CobQ family
A7K99_13705	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A7K99_13710	COG0625	glutathione transferase activity
A7K99_13720	COG4160	amino acid transport
A7K99_13725	COG4215	(ABC) transporter
A7K99_13730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_13735	COG0163	prenyltransferase activity
A7K99_13740	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A7K99_13745	COG1286	toxin biosynthetic process
A7K99_13750	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A7K99_13755	COG0285	dihydrofolate synthase activity
A7K99_13765	COG0586	Pfam SNARE associated Golgi protein
A7K99_13770	COG0101	tRNA pseudouridine synthase activity
A7K99_13775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A7K99_13810	COG1473	amidohydrolase
A7K99_13815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7K99_13830	COG3101	peptidyl-lysine hydroxylation
A7K99_13835	COG0730	response to heat
A7K99_13845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A7K99_13855	COG2840	Smr protein MutS2
A7K99_13860	COG2062	phosphohistidine phosphatase, SixA
A7K99_13870	COG0183	Belongs to the thiolase family
A7K99_13875	COG3691	Protein conserved in bacteria
A7K99_13905	COG1138	Cytochrome C-type biogenesis protein
A7K99_13915	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7K99_13920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7K99_13925	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7K99_13935	COG2116	formate transmembrane transporter activity
A7K99_13940	COG0583	DNA-binding transcription factor activity
A7K99_13970	COG0058	SHG alpha-glucan phosphorylase activity
A7K99_13975	COG0297	glycogen (starch) synthase activity
A7K99_13980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A7K99_13985	COG1523	belongs to the glycosyl hydrolase 13 family
A7K99_13990	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A7K99_14000	COG2390	Transcriptional regulator
A7K99_14005	COG0149	triose-phosphate isomerase activity
A7K99_14010	COG2376	Dihydroxyacetone kinase
A7K99_14015	COG0698	ribose 5-phosphate isomerase
A7K99_14025	COG2271	Major facilitator Superfamily
A7K99_14030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7K99_14060	COG0531	amino acid
A7K99_14065	COG0531	amino acid
A7K99_14070	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A7K99_14070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7K99_14085	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_14095	COG0322	excinuclease ABC activity
A7K99_14100	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A7K99_14105	COG4988	ABC transporter
A7K99_14115	COG1271	oxidase subunit
A7K99_14145	COG2223	nitrite transmembrane transporter activity
A7K99_14170	COG0436	Aminotransferase
A7K99_14175	COG3275	phosphorelay sensor kinase activity
A7K99_14180	COG3279	Response regulator of the LytR AlgR family
A7K99_14185	COG0837	glucose binding
A7K99_14195	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A7K99_14205	COG0628	permease
A7K99_14220	COG3415	Transposase
A7K99_14225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7K99_14265	COG0673	inositol 2-dehydrogenase activity
A7K99_14270	COG1349	DNA-binding transcription factor activity
A7K99_14290	COG0583	DNA-binding transcription factor activity
A7K99_14295	COG0385	Bile acid
A7K99_14300	COG1566	PFAM secretion protein HlyD family protein
A7K99_14305	COG2814	Major facilitator Superfamily
A7K99_14315	COG3530	Putative quorum-sensing-regulated virulence factor
A7K99_14325	COG3115	cell septum assembly
A7K99_14335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7K99_14350	COG2190	(PTS) system
A7K99_14355	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A7K99_14360	COG0463	Glycosyl transferase, family 2
A7K99_14370	COG0726	polysaccharide deacetylase
A7K99_14375	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A7K99_14385	COG2076	Multidrug Resistance protein
A7K99_14390	COG2205	protein histidine kinase activity
A7K99_14395	COG0745	RESPONSE REGULATOR receiver
A7K99_14400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7K99_14410	COG4208	sulfate ABC transporter
A7K99_14415	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A7K99_14425	COG2837	iron assimilation
A7K99_14440	COG0456	acetyltransferase
A7K99_14455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A7K99_14460	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A7K99_14465	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A7K99_14480	COG1393	Belongs to the ArsC family
A7K99_14485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7K99_14495	COG0400	carboxylic ester hydrolase activity
A7K99_14505	COG2321	neutral zinc metallopeptidase
A7K99_14515	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A7K99_14525	COG2716	regulation of RNA biosynthetic process
A7K99_14530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A7K99_14535	COG4783	chaperone-mediated protein folding
A7K99_14540	COG1393	Belongs to the ArsC family
A7K99_14550	COG2233	PERMEase
A7K99_14565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A7K99_14570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A7K99_14575	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A7K99_14580	COG0248	Ppx GppA phosphatase
A7K99_14585	COG0500	methyltransferase
A7K99_14590	COG2239	Acts as a magnesium transporter
A7K99_14595	COG4993	Dehydrogenase
A7K99_14630	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
A7K99_14635	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A7K99_14645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7K99_14650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7K99_14665	COG0477	Major facilitator Superfamily
A7K99_14675	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_14690	COG0300	oxidoreductase activity
A7K99_14695	COG2207	Transcriptional regulator
A7K99_14700	COG2706	6-phosphogluconolactonase activity
A7K99_14730	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A7K99_14745	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A7K99_14755	COG0386	Belongs to the glutathione peroxidase family
A7K99_14770	COG0517	IMP dehydrogenase activity
A7K99_14770	COG0516	GMP reductase activity
A7K99_14775	COG1570	exodeoxyribonuclease VII activity
A7K99_14785	COG1160	GTP binding
A7K99_14790	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7K99_14795	COG2976	Protein conserved in bacteria
A7K99_14800	COG0124	histidyl-tRNA synthetase
A7K99_14805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A7K99_14825	COG0105	UTP biosynthetic process
A7K99_14830	COG2897	thiosulfate sulfurtransferase activity
A7K99_14845	COG2975	iron-sulfur cluster assembly
A7K99_14850	COG0633	Ferredoxin
A7K99_14860	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A7K99_14870	COG0822	iron-sulfur transferase activity
A7K99_14880	COG1959	2 iron, 2 sulfur cluster binding
A7K99_14890	COG0483	inositol monophosphate 1-phosphatase activity
A7K99_14895	COG3711	transcriptional antiterminator
A7K99_14900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7K99_14905	COG1017	nitric oxide dioxygenase activity
A7K99_14905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7K99_14910	COG0347	Belongs to the P(II) protein family
A7K99_14915	COG2204	response regulator
A7K99_14925	COG2205	protein histidine kinase activity
A7K99_14930	COG3385	transposase activity
A7K99_14935	COG0047	phosphoribosylformylglycinamidine synthase activity
A7K99_14935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A7K99_14940	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A7K99_14945	COG0590	tRNA wobble adenosine to inosine editing
A7K99_14975	COG0560	Phosphoserine phosphatase
A7K99_14985	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A7K99_14990	COG0736	holo-[acyl-carrier-protein] synthase activity
A7K99_14995	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A7K99_15010	COG0571	ribonuclease III activity
A7K99_15015	COG0681	Belongs to the peptidase S26 family
A7K99_15020	COG0481	GTPase activity
A7K99_15025	COG3086	response to oxidative stress
A7K99_15045	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A7K99_15050	COG0513	Belongs to the DEAD box helicase family
A7K99_15055	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
A7K99_15065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A7K99_15070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A7K99_15075	COG0497	DNA recombination
A7K99_15080	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7K99_15085	COG2914	Belongs to the UPF0125 (RnfH) family
A7K99_15090	COG2867	negative regulation of translational initiation
A7K99_15145	COG3210	domain, Protein
A7K99_15150	COG2831	hemolysin activation secretion protein
A7K99_15175	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7K99_15195	COG3775	system Galactitol-specific IIC component
A7K99_15210	COG2199	diguanylate cyclase activity
A7K99_15215	COG2885	chlorophyll binding
A7K99_15220	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_15225	COG1733	regulation of RNA biosynthetic process
A7K99_15235	COG0702	epimerase
A7K99_15245	COG4149	molybdate abc transporter
A7K99_15250	COG0725	ABC transporter, periplasmic molybdate-binding protein
A7K99_15255	COG0789	Transcriptional regulator
A7K99_15275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7K99_15285	COG2226	methyltransferase
A7K99_15290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7K99_15295	COG1388	LysM domain
A7K99_15295	COG0741	lytic transglycosylase activity
A7K99_15300	COG3021	interspecies interaction between organisms
A7K99_15305	COG2814	Major facilitator Superfamily
A7K99_15310	COG0583	DNA-binding transcription factor activity
A7K99_15320	COG4521	taurine ABC transporter
A7K99_15330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_15335	COG2175	clavaminate synthase activity
A7K99_15340	COG2814	Major facilitator Superfamily
A7K99_15375	COG0542	response to heat
A7K99_15385	COG0564	pseudouridine synthase activity
A7K99_15390	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7K99_15395	COG3385	transposase activity
A7K99_15400	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A7K99_15405	COG0077	Prephenate dehydratase
A7K99_15405	COG1605	Chorismate mutase
A7K99_15410	COG0287	Prephenate dehydrogenase
A7K99_15410	COG1605	Chorismate mutase
A7K99_15415	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A7K99_15425	COG0436	Aminotransferase
A7K99_15430	COG0583	DNA-binding transcription factor activity
A7K99_15445	COG0765	amino acid transport
A7K99_15450	COG1126	abc transporter atp-binding protein
A7K99_15470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A7K99_15485	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A7K99_15490	COG2195	Cleaves the N-terminal amino acid of tripeptides
A7K99_15505	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7K99_15515	COG3034	peptidoglycan biosynthetic process
A7K99_15520	COG0121	glutamine amidotransferase
A7K99_15530	COG1960	acyl-CoA dehydrogenase activity
A7K99_15545	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A7K99_15550	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
A7K99_15555	COG0436	Aminotransferase
A7K99_15560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7K99_15565	COG2351	hydroxyisourate hydrolase activity
A7K99_15580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A7K99_15620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7K99_15630	COG4575	ribosome binding
A7K99_15640	COG1780	Probably involved in ribonucleotide reductase function
A7K99_15645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7K99_15650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7K99_15655	COG4175	Glycine betaine
A7K99_15660	COG4176	ABC-type proline glycine betaine transport system permease component
A7K99_15670	COG1846	Transcriptional regulator
A7K99_15675	COG1566	PFAM secretion protein HlyD family protein
A7K99_15680	COG2814	Major facilitator Superfamily
A7K99_15685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7K99_15690	COG3118	belongs to the thioredoxin family
A7K99_15700	COG1042	CoA-binding domain protein
A7K99_15700	COG0045	succinate-CoA ligase (ADP-forming) activity
A7K99_15700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7K99_15705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7K99_15720	COG0477	Major facilitator Superfamily
A7K99_15750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A7K99_15760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7K99_15765	COG2011	ABC-type metal ion transport system permease component
A7K99_15780	COG1720	tRNA m6t6A37 methyltransferase activity
A7K99_15785	COG0442	prolyl-tRNA aminoacylation
A7K99_15795	COG4681	YaeQ
A7K99_15800	COG4568	rho-dependent transcription termination
A7K99_15805	COG0037	tRNA processing
A7K99_15810	COG0346	lactoylglutathione lyase activity
A7K99_15815	COG0825	malonyl-CoA metabolic process
A7K99_15820	COG0587	DNA-directed DNA polymerase activity
A7K99_15825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A7K99_15830	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7K99_15840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7K99_15850	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A7K99_15855	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7K99_15865	COG0575	Belongs to the CDS family
A7K99_15870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A7K99_15875	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A7K99_15880	COG0233	cytoplasmic translational termination
A7K99_15885	COG0528	UMP kinase activity
A7K99_15890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A7K99_15900	COG0024	Methionine aminopeptidase
A7K99_15905	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A7K99_15920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7K99_15925	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A7K99_15930	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7K99_15935	COG0316	Belongs to the HesB IscA family
A7K99_15950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7K99_15955	COG1643	Atp-dependent helicase
A7K99_15965	COG1489	DNA binding
A7K99_15970	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A7K99_15985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A7K99_15990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A7K99_15995	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A7K99_16000	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A7K99_16005	COG0842	Transport permease protein
A7K99_16010	COG1131	(ABC) transporter
A7K99_16015	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A7K99_16030	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A7K99_16035	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A7K99_16060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7K99_16065	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7K99_16070	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A7K99_16075	COG2186	Transcriptional regulator
A7K99_16085	COG3725	Membrane protein required for beta-lactamase induction
A7K99_16090	COG3023	N-Acetylmuramoyl-L-alanine amidase
A7K99_16100	COG4969	Belongs to the N-Me-Phe pilin family
A7K99_16105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A7K99_16110	COG1459	type II secretion system
A7K99_16115	COG0516	GMP reductase activity
A7K99_16120	COG0237	dephospho-CoA kinase activity
A7K99_16130	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A7K99_16135	COG0494	nUDIX hydrolase
A7K99_16150	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A7K99_16155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A7K99_16160	COG0849	cell division
A7K99_16170	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7K99_16180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A7K99_16185	COG0772	Belongs to the SEDS family
A7K99_16200	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A7K99_16205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7K99_16210	COG0768	penicillin binding
A7K99_16215	COG3116	cell division
A7K99_16220	COG0275	rRNA processing
A7K99_16225	COG2001	Belongs to the MraZ family
A7K99_16230	COG1609	Transcriptional regulator
A7K99_16240	COG0028	Belongs to the TPP enzyme family
A7K99_16245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7K99_16255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A7K99_16260	COG0066	3-isopropylmalate dehydratase activity
A7K99_16265	COG2814	Major facilitator Superfamily
A7K99_16275	COG4143	(ABC) transporter
A7K99_16280	COG1178	ABC-type Fe3 transport system permease component
A7K99_16290	COG0586	Pfam SNARE associated Golgi protein
A7K99_16295	COG0417	DNA replication proofreading
A7K99_16300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7K99_16305	COG0564	pseudouridine synthase activity
A7K99_16310	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A7K99_16325	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A7K99_16330	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A7K99_16335	COG2967	ApaG domain
A7K99_16340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A7K99_16345	COG2723	6-phospho-beta-galactosidase activity
A7K99_16370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A7K99_16375	COG0505	Belongs to the CarA family
A7K99_16380	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A7K99_16385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A7K99_16390	COG1047	Peptidyl-prolyl cis-trans
A7K99_16395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A7K99_16400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A7K99_16405	COG0196	riboflavin kinase activity
A7K99_16410	COG0268	Binds directly to 16S ribosomal RNA
A7K99_16435	COG0521	Mo-molybdopterin cofactor biosynthetic process
A7K99_16450	COG4319	ketosteroid isomerase
A7K99_16465	COG0527	aspartate kinase activity
A7K99_16465	COG0460	homoserine dehydrogenase
A7K99_16470	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A7K99_16475	COG0745	RESPONSE REGULATOR receiver
A7K99_16480	COG3045	CreA protein
A7K99_16485	COG3708	Transcriptional regulator
A7K99_16485	COG2207	Transcriptional regulator
A7K99_16495	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A7K99_16505	COG0741	lytic transglycosylase activity
A7K99_16515	COG0439	Biotin carboxylase
A7K99_16530	COG0559	Belongs to the binding-protein-dependent transport system permease family
A7K99_16540	COG0411	ABC transporter
A7K99_16560	COG0697	spore germination
A7K99_16565	COG0488	(ABC) transporter
A7K99_16580	COG0560	Phosphoserine phosphatase
A7K99_16595	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_16605	COG0583	DNA-binding transcription factor activity
A7K99_16610	COG1011	Hydrolase
A7K99_16615	COG0456	acetyltransferase
A7K99_16620	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A7K99_16655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A7K99_16660	COG2814	Major facilitator Superfamily
A7K99_16670	COG5455	response to cobalt ion
A7K99_16695	COG0411	ABC transporter
A7K99_16700	COG0410	ABC transporter
A7K99_16725	COG2079	MmgE PrpD family protein
A7K99_16735	COG1126	abc transporter atp-binding protein
A7K99_16750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7K99_16760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_16770	COG0583	DNA-binding transcription factor activity
A7K99_16775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7K99_16800	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7K99_16810	COG1012	belongs to the aldehyde dehydrogenase family
A7K99_16815	COG0463	Glycosyl transferase, family 2
A7K99_16830	COG4774	siderophore transport
A7K99_16840	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7K99_16845	COG2199	diguanylate cyclase activity
A7K99_16850	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A7K99_16860	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7K99_16860	COG1902	pentaerythritol trinitrate reductase activity
A7K99_16865	COG2813	Specifically methylates the guanine in position
A7K99_16870	COG0038	chloride channel
A7K99_16875	COG0861	Integral membrane protein TerC family
A7K99_16885	COG0586	Pfam SNARE associated Golgi protein
A7K99_16895	COG1422	Protein of unknown function (DUF1090)
A7K99_16900	COG4575	ribosome binding
A7K99_16905	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
A7K99_16915	COG0435	Glutathione S-transferase
A7K99_16920	COG0583	DNA-binding transcription factor activity
A7K99_16925	COG1741	Belongs to the pirin family
A7K99_16930	COG2823	Periplasmic or secreted lipoprotein
A7K99_16945	COG3107	peptidoglycan biosynthetic process
A7K99_16950	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A7K99_16960	COG0583	DNA-binding transcription factor activity
A7K99_16965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_16970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_16995	COG0235	Class ii aldolase
A7K99_17000	COG3783	Cytochrome b(562)
A7K99_17005	COG0312	modulator of DNA gyrase
A7K99_17015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A7K99_17020	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A7K99_17030	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A7K99_17035	COG2105	PFAM AIG2 family protein
A7K99_17045	COG0729	surface antigen
A7K99_17050	COG1253	flavin adenine dinucleotide binding
A7K99_17060	COG1218	3'(2'),5'-bisphosphate nucleotidase
A7K99_17065	COG0545	Peptidyl-prolyl cis-trans isomerase
A7K99_17070	COG3061	Opacity-associated protein A
A7K99_17090	COG0360	Binds together with S18 to 16S ribosomal RNA
A7K99_17105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7K99_17110	COG0557	exoribonuclease II activity
A7K99_17120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A7K99_17125	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A7K99_17130	COG0330	HflC and HflK could
A7K99_17135	COG0330	HflC and HflK could
A7K99_17140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A7K99_17150	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A7K99_17155	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A7K99_17165	COG0802	atpase or kinase
A7K99_17170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A7K99_17170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A7K99_17185	COG0583	DNA-binding transcription factor activity
A7K99_17220	COG0688	phosphatidylethanolamine metabolic process
A7K99_17225	COG1511	domain protein
A7K99_17225	COG3264	Mechanosensitive ion channel
A7K99_17230	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A7K99_17235	COG5510	response to toxic substance
A7K99_17245	COG1509	lysine 2,3-aminomutase activity
A7K99_17265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A7K99_17270	COG3030	protein affecting phage T7 exclusion by the F plasmid
A7K99_17275	COG1027	Aspartate ammonia-lyase
A7K99_17290	COG1309	transcriptional regulator
A7K99_17295	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A7K99_17300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A7K99_17310	COG1175	transmembrane transport
A7K99_17315	COG1840	ABC-type Fe3 transport system, periplasmic component
A7K99_17320	COG1609	Transcriptional regulator
A7K99_17345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_17360	COG1902	pentaerythritol trinitrate reductase activity
A7K99_17365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_17375	COG0583	DNA-binding transcription factor activity
A7K99_17380	COG1902	pentaerythritol trinitrate reductase activity
A7K99_17385	COG2814	Major facilitator Superfamily
A7K99_17410	COG0583	DNA-binding transcription factor activity
A7K99_17430	COG0583	DNA-binding transcription factor activity
A7K99_17435	COG0477	Major facilitator Superfamily
A7K99_17460	COG2011	ABC-type metal ion transport system permease component
A7K99_17465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7K99_17470	COG1464	Belongs to the NlpA lipoprotein family
A7K99_17485	COG2011	ABC-type metal ion transport system permease component
A7K99_17490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7K99_17495	COG1464	Belongs to the NlpA lipoprotein family
A7K99_17500	COG0436	Aminotransferase
A7K99_17510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_17515	COG0765	amino acid transport
A7K99_17520	COG0765	amino acid transport
A7K99_17525	COG1126	abc transporter atp-binding protein
A7K99_17530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_17535	COG3711	transcriptional antiterminator
A7K99_17540	COG2723	6-phospho-beta-galactosidase activity
A7K99_17545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7K99_17545	COG2190	(PTS) system
A7K99_17545	COG1263	PTS System
A7K99_17565	COG0765	amino acid transport
A7K99_17570	COG0765	amino acid transport
A7K99_17580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7K99_17600	COG2233	PERMEase
A7K99_17620	COG2372	response to copper ion
A7K99_17630	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7K99_17635	COG1129	ABC transporter
A7K99_17640	COG1879	ABC-type sugar transport system periplasmic component
A7K99_17645	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7K99_17650	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7K99_17655	COG1129	ABC transporter
A7K99_17660	COG1879	ABC-type sugar transport system periplasmic component
A7K99_17690	COG3121	Chaperone
A7K99_17705	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A7K99_17720	COG2814	Major facilitator Superfamily
A7K99_17725	COG0583	DNA-binding transcription factor activity
A7K99_17735	COG3248	Nucleoside-binding outer membrane protein
A7K99_17740	COG2271	Major facilitator Superfamily
A7K99_17760	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A7K99_17775	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A7K99_17780	COG1301	dicarboxylic acid transport
A7K99_17785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7K99_17790	COG3162	membrane
A7K99_17795	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7K99_17810	COG1380	Effector of murein hydrolase LrgA
A7K99_17815	COG0583	DNA-binding transcription factor activity
A7K99_17820	COG0025	NhaP-type Na H and K H
A7K99_17825	COG0789	Transcriptional regulator
A7K99_17850	COG4993	Dehydrogenase
A7K99_17855	COG3961	Belongs to the TPP enzyme family
A7K99_17860	COG0583	DNA-binding transcription factor activity
A7K99_17880	COG4191	Histidine kinase
A7K99_17890	COG2807	transmembrane transport
A7K99_17910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7K99_17930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7K99_17935	COG5000	phosphorelay sensor kinase activity
A7K99_17935	COG5002	protein histidine kinase activity
A7K99_17940	COG0745	RESPONSE REGULATOR receiver
A7K99_17955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A7K99_17980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7K99_17990	COG0745	RESPONSE REGULATOR receiver
A7K99_17995	COG0642	Histidine kinase
A7K99_18005	COG2963	transposase activity
A7K99_18035	COG0629	single-stranded DNA binding
A7K99_18040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A7K99_18045	COG1064	alcohol dehydrogenase
A7K99_18055	COG0667	Aldo Keto reductase
A7K99_18060	COG0583	DNA-binding transcription factor activity
A7K99_18065	COG1942	4-Oxalocrotonate Tautomerase
A7K99_18070	COG1609	Transcriptional regulator
A7K99_18075	COG1448	Aminotransferase
A7K99_18085	COG1522	sequence-specific DNA binding
A7K99_18090	COG0305	Participates in initiation and elongation during chromosome replication
A7K99_18105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7K99_18115	COG1216	Glycosyl transferase, family 2
A7K99_18115	COG1442	glycosyl transferase family 8
A7K99_18120	COG0735	belongs to the Fur family
A7K99_18125	COG0534	Mate efflux family protein
A7K99_18130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A7K99_18135	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A7K99_18145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A7K99_18155	COG3223	Belongs to the PsiE family
A7K99_18170	COG0527	aspartate kinase activity
A7K99_18180	COG1283	sodium-dependent phosphate transmembrane transporter activity
A7K99_18185	COG3842	ATPase activity
A7K99_18215	COG0667	Aldo Keto reductase
A7K99_18220	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A7K99_18225	COG0583	DNA-binding transcription factor activity
A7K99_18230	COG1473	amidohydrolase
A7K99_18240	COG3385	transposase activity
A7K99_18290	COG0151	Belongs to the GarS family
A7K99_18295	COG3385	transposase activity
A7K99_18305	COG0776	regulation of translation
A7K99_18310	COG3068	Protein conserved in bacteria
A7K99_18315	COG1515	deoxyribonuclease V activity
A7K99_18325	COG2816	NAD+ diphosphatase activity
A7K99_18340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A7K99_18345	COG2104	thiamine diphosphate biosynthetic process
A7K99_18350	COG2022	thiamine diphosphate biosynthetic process
A7K99_18360	COG5342	invasion associated locus B
A7K99_18370	COG0085	RNA polymerase activity
A7K99_18380	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A7K99_18385	COG0081	regulation of translation
A7K99_18390	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A7K99_18395	COG0250	Participates in transcription elongation, termination and antitermination
A7K99_18400	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A7K99_18435	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A7K99_18435	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A7K99_18440	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A7K99_18475	COG1739	Uncharacterized protein family UPF0029
A7K99_18490	COG0183	Belongs to the thiolase family
A7K99_18510	COG0084	hydrolase, TatD family'
A7K99_18515	COG0805	protein transport
A7K99_18525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7K99_18530	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A7K99_18535	COG3165	ubiquinone biosynthetic process from chorismate
A7K99_18540	COG2226	methyltransferase
A7K99_18545	COG1322	Protein conserved in bacteria
A7K99_18550	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A7K99_18555	COG0412	Dienelactone hydrolase
A7K99_18565	COG1187	pseudouridine synthase activity
A7K99_18570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A7K99_18575	COG0583	DNA-binding transcription factor activity
A7K99_18580	COG2271	Major facilitator Superfamily
A7K99_18585	COG0561	phosphatase activity
A7K99_18590	COG2267	carboxylic ester hydrolase activity
A7K99_18595	COG1280	lysine exporter protein (LysE YggA)
A7K99_18600	COG1280	lysine exporter protein (LysE YggA)
A7K99_18610	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
A7K99_18615	COG2050	protein possibly involved in aromatic compounds catabolism
A7K99_18625	COG2271	Major facilitator Superfamily
A7K99_18630	COG0583	DNA-binding transcription factor activity
A7K99_18635	COG0154	amidase activity
A7K99_18645	COG0583	DNA-binding transcription factor activity
A7K99_18655	COG0598	Magnesium transport protein CorA
A7K99_18660	COG0210	DNA helicase
A7K99_18665	COG1011	Hydrolase
A7K99_18680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A7K99_18685	COG5567	small periplasmic lipoprotein
A7K99_18695	COG3072	Adenylate cyclase
A7K99_18700	COG0181	hydroxymethylbilane synthase activity
A7K99_18705	COG1587	Uroporphyrinogen-III synthase
A7K99_18710	COG2959	enzyme of heme biosynthesis
A7K99_18715	COG3071	HemY protein
A7K99_18720	COG0431	NADPH-dependent FMN reductase
A7K99_18730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7K99_18765	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A7K99_18775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A7K99_18780	COG2244	polysaccharide biosynthetic process
A7K99_18785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A7K99_18790	COG0456	acetyltransferase
A7K99_18795	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A7K99_18800	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A7K99_18810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7K99_18815	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A7K99_18820	COG3118	belongs to the thioredoxin family
A7K99_18825	COG0513	Belongs to the DEAD box helicase family
A7K99_18830	COG0248	Ppx GppA phosphatase
A7K99_18840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7K99_18850	COG1309	transcriptional regulator
A7K99_18860	COG2199	diguanylate cyclase activity
A7K99_18860	COG2200	EAL domain
A7K99_18865	COG4608	Belongs to the ABC transporter superfamily
A7K99_18870	COG0444	Belongs to the ABC transporter superfamily
A7K99_18875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7K99_18880	COG0601	transmembrane transport
A7K99_18885	COG0747	negative chemotaxis
A7K99_18925	COG2990	Protein conserved in bacteria
A7K99_18935	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7K99_18940	COG1349	DNA-binding transcription factor activity
A7K99_18950	COG0751	glycine-tRNA ligase activity
A7K99_18955	COG0752	glycyl-tRNA synthetase alpha subunit
A7K99_18975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_18980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_18985	COG1116	anion transmembrane transporter activity
A7K99_19000	COG2207	Transcriptional regulator
A7K99_19015	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_19025	COG4807	Protein conserved in bacteria
A7K99_19035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7K99_19040	COG0710	3-dehydroquinate dehydratase activity
A7K99_19050	COG3420	alginic acid biosynthetic process
A7K99_19055	COG1811	Na channel or pump
A7K99_19065	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A7K99_19070	COG0583	DNA-binding transcription factor activity
A7K99_19075	COG0833	amino acid
A7K99_19080	COG2040	homocysteine
A7K99_19095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7K99_19135	COG3193	protein, possibly involved in utilization of glycolate and propanediol
A7K99_19150	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A7K99_19160	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7K99_19165	COG1129	ABC transporter
A7K99_19170	COG1879	ABC-type sugar transport system periplasmic component
A7K99_19175	COG1070	Carbohydrate kinase
A7K99_19180	COG0246	Mannitol dehydrogenase
A7K99_19190	COG4336	lyase activity
A7K99_19200	COG1984	allophanate hydrolase subunit 2
A7K99_19205	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A7K99_19215	COG0583	DNA-binding transcription factor activity
A7K99_19220	COG0583	DNA-binding transcription factor activity
A7K99_19225	COG3366	ferrous iron transmembrane transporter activity
A7K99_19230	COG0700	Nucleoside recognition
A7K99_19235	COG1473	amidohydrolase
A7K99_19260	COG0531	amino acid
A7K99_19270	COG0531	amino acid
A7K99_19275	COG0124	histidyl-tRNA synthetase
A7K99_19295	COG0583	DNA-binding transcription factor activity
A7K99_19300	COG0477	Major facilitator Superfamily
A7K99_19305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7K99_19310	COG2364	Membrane
A7K99_19325	COG2207	Transcriptional regulator
A7K99_19325	COG3708	Transcriptional regulator
A7K99_19335	COG1881	PFAM PEBP family protein
A7K99_19350	COG0583	DNA-binding transcription factor activity
A7K99_19355	COG1271	oxidase subunit
A7K99_19360	COG1294	oxidase, subunit
A7K99_19370	COG2081	HI0933 family
A7K99_19375	COG0306	phosphate transporter
A7K99_19380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A7K99_19385	COG1126	abc transporter atp-binding protein
A7K99_19390	COG0765	amino acid transport
A7K99_19395	COG0765	amino acid transport
A7K99_19415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7K99_19425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A7K99_19435	COG1802	Transcriptional regulator
A7K99_19445	COG0589	response to stress
A7K99_19450	COG0742	ribosomal rna small subunit methyltransferase
A7K99_19460	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A7K99_19470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7K99_19490	COG2851	Citrate transporter
A7K99_19505	COG2985	domain, Protein
A7K99_19510	COG4191	Histidine kinase
A7K99_19520	COG4774	siderophore transport
A7K99_19530	COG2814	Major facilitator Superfamily
A7K99_19535	COG0583	DNA-binding transcription factor activity
A7K99_19545	COG2862	Uncharacterized protein family, UPF0114
A7K99_19565	COG1132	(ABC) transporter
A7K99_19580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7K99_19585	COG0601	transmembrane transport
A7K99_19590	COG0747	negative chemotaxis
A7K99_19600	COG4172	Belongs to the ABC transporter superfamily
A7K99_19610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A7K99_19615	COG1971	Probably functions as a manganese efflux pump
A7K99_19630	COG0625	glutathione transferase activity
A7K99_19635	COG1295	ribonuclease BN
A7K99_19645	COG0477	Major facilitator Superfamily
A7K99_19655	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A7K99_19660	COG0583	DNA-binding transcription factor activity
A7K99_19670	COG0129	dihydroxy-acid dehydratase activity
A7K99_19675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A7K99_19680	COG3978	acetolactate synthase activity
A7K99_19695	COG3085	chromosome segregation
A7K99_19700	COG0583	DNA-binding transcription factor activity
A7K99_19740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7K99_19750	COG1309	transcriptional regulator
A7K99_19755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7K99_19765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A7K99_19765	COG0678	peroxiredoxin activity
A7K99_19775	COG0137	argininosuccinate synthase activity
A7K99_19785	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A7K99_19790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7K99_19795	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A7K99_19805	COG0527	aspartate kinase activity
A7K99_19805	COG0460	homoserine dehydrogenase
A7K99_19810	COG0626	cystathionine gamma-synthase activity
A7K99_19820	COG0254	rRNA binding
A7K99_19825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A7K99_19830	COG1609	Transcriptional regulator
A7K99_19835	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A7K99_19840	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A7K99_19850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A7K99_19855	COG3074	FtsZ-dependent cytokinesis
A7K99_19860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A7K99_19870	COG1494	fructose-1,6-bisphosphatase
A7K99_19875	COG2814	Major facilitator Superfamily
A7K99_19890	COG0149	triose-phosphate isomerase activity
A7K99_19895	COG2134	cdp-diacylglycerol pyrophosphatase
A7K99_19900	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A7K99_19905	COG0205	6-phosphofructokinase activity
A7K99_19915	COG3539	Fimbrial protein
A7K99_19935	COG3539	Fimbrial protein
A7K99_19940	COG3710	Transcriptional regulator
A7K99_19950	COG3678	ATP-independent chaperone mediated protein folding
A7K99_19955	COG0745	RESPONSE REGULATOR receiver
A7K99_19960	COG2205	protein histidine kinase activity
A7K99_19965	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A7K99_19975	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A7K99_19980	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A7K99_19985	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A7K99_19990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7K99_19995	COG4942	peptidase
A7K99_20000	COG2861	carbohydrate metabolic process
A7K99_20005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7K99_20010	COG0859	PFAM glycosyl transferase family 9
A7K99_20015	COG0859	PFAM glycosyl transferase family 9
A7K99_20025	COG3307	-O-antigen
A7K99_20035	COG0438	transferase activity, transferring glycosyl groups
A7K99_20040	COG0859	PFAM glycosyl transferase family 9
A7K99_20045	COG0859	PFAM glycosyl transferase family 9
A7K99_20050	COG0438	transferase activity, transferring glycosyl groups
A7K99_20055	COG1519	Transferase
A7K99_20070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A7K99_20080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A7K99_20085	COG2003	Belongs to the UPF0758 family
A7K99_20090	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A7K99_20100	COG1309	transcriptional regulator
A7K99_20110	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A7K99_20115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A7K99_20125	COG1561	YicC-like family, N-terminal region
A7K99_20130	COG1846	Transcriptional regulator
A7K99_20140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7K99_20140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7K99_20155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A7K99_20160	COG3084	Protein conserved in bacteria
A7K99_20165	COG3385	transposase activity
A7K99_20170	COG0746	molybdenum cofactor guanylyltransferase activity
A7K99_20175	COG1763	Mo-molybdopterin cofactor biosynthetic process
A7K99_20205	COG0477	Major facilitator Superfamily
A7K99_20210	COG1609	Transcriptional regulator
A7K99_20215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7K99_20220	COG1879	ABC-type sugar transport system periplasmic component
A7K99_20225	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7K99_20230	COG1129	ABC transporter
A7K99_20245	COG0714	Associated with various cellular activities
A7K99_20250	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A7K99_20255	COG1522	sequence-specific DNA binding
A7K99_20260	COG0716	FMN binding
A7K99_20275	COG3312	ion transport
A7K99_20280	COG0356	it plays a direct role in the translocation of protons across the membrane
A7K99_20295	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7K99_20300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A7K99_20305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A7K99_20310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A7K99_20325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7K99_20330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A7K99_20335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_20350	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A7K99_20355	COG1028	Short-chain dehydrogenase reductase Sdr
A7K99_20390	COG0583	DNA-binding transcription factor activity
A7K99_20395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A7K99_20435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_20435	COG1116	anion transmembrane transporter activity
A7K99_20455	COG1116	anion transmembrane transporter activity
A7K99_20460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_20470	COG0154	amidase activity
A7K99_20475	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A7K99_20480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7K99_20485	COG3539	Fimbrial protein
A7K99_20490	COG3539	Fimbrial protein
A7K99_20495	COG3121	Chaperone
A7K99_20500	COG3188	usher protein
A7K99_20505	COG3539	Fimbrial protein
A7K99_20510	COG3539	Fimbrial protein
A7K99_20515	COG3539	Fimbrial protein
A7K99_20520	COG3539	Fimbrial protein
A7K99_20545	COG3707	response regulator
A7K99_20555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7K99_20565	COG1116	anion transmembrane transporter activity
A7K99_20570	COG2146	nitrite reductase [NAD(P)H] activity
A7K99_20570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7K99_20575	COG1648	precorrin-2 dehydrogenase activity
A7K99_20575	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7K99_20580	COG0243	molybdopterin cofactor binding
A7K99_20585	COG2207	Transcriptional regulator
A7K99_20625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7K99_20630	COG1464	Belongs to the NlpA lipoprotein family
A7K99_20645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7K99_20665	COG0765	amino acid transport
A7K99_20670	COG1126	abc transporter atp-binding protein
A7K99_20685	COG4772	TonB-dependent receptor
A7K99_20690	COG3712	iron ion homeostasis
A7K99_20695	COG1595	DNA-templated transcription, initiation
A7K99_20715	COG2706	6-phosphogluconolactonase activity
A7K99_20720	COG2271	Major facilitator Superfamily
A7K99_20725	COG1609	Transcriptional regulator
A7K99_20740	COG3395	kinase activity
A7K99_20745	COG2707	UPF0756 membrane protein
A7K99_20775	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A7K99_20785	COG3078	GTPase activator activity
A7K99_20790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7K99_20800	COG3852	Histidine kinase
A7K99_20805	COG0174	glutamine synthetase
A7K99_20820	COG0477	Major facilitator Superfamily
A7K99_20830	COG2207	Transcriptional regulator
A7K99_20850	COG1011	Hydrolase
A7K99_20865	COG0456	acetyltransferase
A7K99_20870	COG2982	Protein involved in outer membrane biogenesis
A7K99_20875	COG2233	PERMEase
A7K99_20880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A7K99_20885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7K99_20890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A7K99_20895	COG1758	RNA polymerase activity
A7K99_20910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A7K99_20915	COG0573	inorganic phosphate transmembrane transporter activity
A7K99_20920	COG0581	inorganic phosphate transmembrane transporter activity
A7K99_20930	COG0704	Plays a role in the regulation of phosphate uptake
A7K99_20935	COG2814	Major facilitator Superfamily
A7K99_20965	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A7K99_20970	COG0706	membrane insertase activity
A7K99_20975	COG0594	ribonuclease P activity