locus-tag	class	description
KUI_0005	COG4608	Belongs to the ABC transporter superfamily
KUI_0006	COG0601	transmembrane transport
KUI_0007	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KUI_0008	COG0444	Belongs to the ABC transporter superfamily
KUI_0009	COG4166	transmembrane transport
KUI_0011	COG1074	ATP-dependent DNA helicase activity
KUI_0014	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KUI_0014	COG0551	DNA topoisomerase type I activity
KUI_0015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KUI_0017	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KUI_0018	COG2922	Belongs to the Smg family
KUI_0020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KUI_0022	COG0018	arginyl-trna synthetase
KUI_0024	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KUI_0030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KUI_0034	COG1160	GTP binding
KUI_0038	COG2431	L-lysine efflux transmembrane transporter activity
KUI_0040	COG4215	(ABC) transporter
KUI_0041	COG4160	amino acid transport
KUI_0042	COG4598	ABC transporter
KUI_0043	COG0730	response to heat
KUI_0046	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KUI_0048	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KUI_0050	COG1994	Peptidase M50
KUI_0051	COG0859	PFAM glycosyl transferase family 9
KUI_0054	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KUI_0056	COG2945	thiolester hydrolase activity
KUI_0057	COG1686	Belongs to the peptidase S11 family
KUI_0059	COG2921	Belongs to the UPF0250 family
KUI_0060	COG0321	lipoyl(octanoyl) transferase activity
KUI_0063	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KUI_0064	COG1088	dTDP-glucose 4,6-dehydratase activity
KUI_0065	COG2814	Major facilitator Superfamily
KUI_0066	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KUI_0070	COG0513	Belongs to the DEAD box helicase family
KUI_0071	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KUI_0072	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KUI_0072	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KUI_0075	COG2204	response regulator
KUI_0076	COG0569	domain protein
KUI_0078	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KUI_0079	COG1040	competence protein
KUI_0080	COG2226	methyltransferase
KUI_0111	COG3501	Rhs element vgr protein
KUI_0145	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KUI_0146	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KUI_0147	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KUI_0149	COG0588	phosphoglycerate mutase activity
KUI_0150	COG4942	peptidase
KUI_0151	COG0793	Belongs to the peptidase S41A family
KUI_0152	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KUI_0153	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KUI_0156	COG0356	it plays a direct role in the translocation of protons across the membrane
KUI_0158	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KUI_0159	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KUI_0160	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KUI_0161	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KUI_0162	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KUI_0163	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KUI_0168	COG1131	(ABC) transporter
KUI_0174	COG0523	cobalamin synthesis protein
KUI_0175	COG0735	belongs to the Fur family
KUI_0177	COG1121	(ABC) transporter
KUI_0178	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KUI_0180	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KUI_0183	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KUI_0185	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KUI_0186	COG1077	Cell shape determining protein MreB Mrl
KUI_0189	COG0768	penicillin binding
KUI_0190	COG0772	Belongs to the SEDS family
KUI_0191	COG2177	Part of the ABC transporter FtsEX involved in
KUI_0192	COG2884	Cell division ATP-binding protein ftsE
KUI_0193	COG4597	amino acid ABC transporter
KUI_0194	COG0765	amino acid transport
KUI_0195	COG1126	abc transporter atp-binding protein
KUI_0199	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KUI_0203	COG0237	dephospho-CoA kinase activity
KUI_0204	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
KUI_0205	COG1045	serine acetyltransferase
KUI_0208	COG0142	geranyltranstransferase activity
KUI_0209	COG0129	dihydroxy-acid dehydratase activity
KUI_0210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KUI_0213	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KUI_0214	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KUI_0216	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KUI_0218	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KUI_0219	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KUI_0220	COG0179	Fumarylacetoacetate (FAA) hydrolase
KUI_0225	COG1518	maintenance of DNA repeat elements
KUI_0232	COG0601	transmembrane transport
KUI_0233	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KUI_0235	COG4608	Belongs to the ABC transporter superfamily
KUI_0240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KUI_0242	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KUI_0243	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
KUI_0244	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KUI_0246	COG2823	Periplasmic or secreted lipoprotein
KUI_0247	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KUI_0248	COG0792	nuclease activity
KUI_0252	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KUI_0254	COG1137	ATPase activity
KUI_0257	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KUI_0259	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KUI_0260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KUI_0262	COG0745	RESPONSE REGULATOR receiver
KUI_0263	COG2226	methyltransferase
KUI_0265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KUI_0266	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KUI_0268	COG0351	phosphomethylpyrimidine kinase
KUI_0269	COG2326	polyphosphate kinase activity
KUI_0273	COG0720	synthase
KUI_0274	COG0602	queuosine metabolic process
KUI_0279	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KUI_0280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KUI_0281	COG2890	protein-(glutamine-N5) methyltransferase activity
KUI_0282	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KUI_0285	COG0471	metal ion transport
KUI_0292	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KUI_0292	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KUI_0294	COG2830	Protein of unknown function (DUF452)
KUI_0295	COG0500	methyltransferase
KUI_0296	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KUI_0297	COG0584	glycerophosphoryl diester phosphodiesterase
KUI_0298	COG1063	alcohol dehydrogenase
KUI_0301	COG2119	membrane
KUI_0303	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KUI_0303	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KUI_0305	COG4771	TonB-dependent receptor
KUI_0305	COG1629	transport
KUI_0306	COG0037	tRNA processing
KUI_0308	COG0492	ferredoxin-NADP+ reductase activity
KUI_0311	COG4215	(ABC) transporter
KUI_0312	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KUI_0314	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KUI_0315	COG0589	response to stress
KUI_0316	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KUI_0317	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KUI_0327	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KUI_0328	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KUI_0329	COG1652	LysM domain
KUI_0330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KUI_0336	COG0717	Belongs to the dCTP deaminase family
KUI_0337	COG2081	HI0933 family
KUI_0339	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KUI_0340	COG0509	glycine decarboxylation via glycine cleavage system
KUI_0341	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KUI_0341	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KUI_0342	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KUI_0343	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KUI_0344	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KUI_0346	COG0277	FAD linked oxidase domain protein
KUI_0347	COG0457	Tetratricopeptide repeat
KUI_0348	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KUI_0349	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KUI_0351	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KUI_0352	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KUI_0358	COG0193	aminoacyl-tRNA hydrolase activity
KUI_0360	COG0012	GTP binding
KUI_0361	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KUI_0362	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KUI_0363	COG0742	ribosomal rna small subunit methyltransferase
KUI_0368	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KUI_0369	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KUI_0370	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KUI_0371	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KUI_0372	COG1546	Belongs to the CinA family
KUI_0373	COG0284	orotidine-5'-phosphate decarboxylase activity
KUI_0374	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KUI_0375	COG0459	protein refolding
KUI_0376	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KUI_0377	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KUI_0383	COG0823	Involved in the tonB-independent uptake of proteins
KUI_0386	COG0811	peptide transport
KUI_0387	COG0824	Thioesterase
KUI_0388	COG0442	prolyl-tRNA aminoacylation
KUI_0389	COG0494	nUDIX hydrolase
KUI_0395	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KUI_0395	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KUI_0395	COG0506	proline dehydrogenase activity
KUI_0396	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KUI_0397	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KUI_0405	COG5295	Hep Hag repeat protein
KUI_0406	COG0733	neurotransmitter:sodium symporter activity
KUI_0409	COG0438	transferase activity, transferring glycosyl groups
KUI_0416	COG0367	asparagine synthase
KUI_0419	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KUI_0427	COG0418	dihydroorotase activity
KUI_0430	COG0747	negative chemotaxis
KUI_0431	COG0747	negative chemotaxis
KUI_0432	COG0601	transmembrane transport
KUI_0433	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KUI_0434	COG0444	Belongs to the ABC transporter superfamily
KUI_0435	COG4608	Belongs to the ABC transporter superfamily
KUI_0438	COG0149	triose-phosphate isomerase activity
KUI_0439	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KUI_0444	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
KUI_0445	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KUI_0446	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KUI_0448	COG0649	NAD binding
KUI_0449	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KUI_0451	COG1034	ATP synthesis coupled electron transport
KUI_0452	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KUI_0453	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KUI_0455	COG0713	ATP synthesis coupled electron transport
KUI_0458	COG1007	ATP synthesis coupled electron transport
KUI_0460	COG0560	Phosphoserine phosphatase
KUI_0461	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KUI_0462	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KUI_0462	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KUI_0463	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KUI_0464	COG0450	alkyl hydroperoxide reductase
KUI_0465	COG2205	protein histidine kinase activity
KUI_0466	COG0745	RESPONSE REGULATOR receiver
KUI_0467	COG1214	PFAM Peptidase M22, glycoprotease
KUI_0470	COG1196	nuclear chromosome segregation
KUI_0472	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KUI_0473	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KUI_0475	COG2917	probably involved in intracellular septation
KUI_0480	COG0411	ABC transporter
KUI_0481	COG0410	ABC transporter
KUI_0482	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KUI_0483	COG2878	Part of a membrane complex involved in electron transport
KUI_0484	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KUI_0486	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KUI_0487	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KUI_0488	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KUI_0489	COG1530	ribonuclease E activity
KUI_0490	COG0564	pseudouridine synthase activity
KUI_0493	COG0424	maF-like protein
KUI_0495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KUI_0496	COG0416	fatty acid biosynthetic process
KUI_0497	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KUI_0498	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KUI_0499	COG1028	Short-chain dehydrogenase reductase Sdr
KUI_0500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KUI_0501	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KUI_0503	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KUI_0504	COG0481	GTPase activity
KUI_0505	COG0681	Belongs to the peptidase S26 family
KUI_0506	COG0571	ribonuclease III activity
KUI_0507	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KUI_0508	COG1381	Involved in DNA repair and RecF pathway recombination
KUI_0509	COG0670	Belongs to the BI1 family
KUI_0511	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KUI_0513	COG0583	DNA-binding transcription factor activity
KUI_0514	COG3226	Transcriptional regulator
KUI_0517	COG0791	NLP P60 protein
KUI_0521	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KUI_0522	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KUI_0525	COG0254	rRNA binding
KUI_0526	COG2003	Belongs to the UPF0758 family
KUI_0527	COG1047	Peptidyl-prolyl cis-trans
KUI_0529	COG0424	maF-like protein
KUI_0530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KUI_0531	COG0799	negative regulation of ribosome biogenesis
KUI_0532	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KUI_0534	COG0217	transcriptional regulatory protein
KUI_0535	COG0433	COG0433 Predicted ATPase
KUI_0536	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
KUI_0537	COG0308	aminopeptidase N
KUI_0538	COG0312	modulator of DNA gyrase
KUI_0539	COG0482	sulfurtransferase activity
KUI_0541	COG3909	cytochrome
KUI_0545	COG0069	glutamate synthase activity
KUI_0547	COG4290	ribonuclease
KUI_0551	COG2951	lytic endotransglycosylase activity
KUI_0552	COG0793	Belongs to the peptidase S41A family
KUI_0558	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KUI_0559	COG1605	Chorismate mutase
KUI_0559	COG0077	Prephenate dehydratase
KUI_0560	COG0287	Prephenate dehydrogenase
KUI_0561	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KUI_0563	COG0776	regulation of translation
KUI_0565	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KUI_0566	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KUI_0567	COG1555	photosystem II stabilization
KUI_0567	COG1596	polysaccharide export
KUI_0568	COG2608	mercury ion transmembrane transporter activity
KUI_0568	COG2217	Heavy metal translocating P-type atpase
KUI_0570	COG3278	Belongs to the heme-copper respiratory oxidase family
KUI_0576	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KUI_0578	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KUI_0580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KUI_0586	COG0495	leucyl-tRNA aminoacylation
KUI_0587	COG2195	Cleaves the N-terminal amino acid of tripeptides
KUI_0588	COG2850	peptidyl-arginine hydroxylation
KUI_0589	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KUI_0590	COG0668	transmembrane transport
KUI_0593	COG1968	undecaprenyl-diphosphatase activity
KUI_0594	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KUI_0597	COG0215	cysteine-tRNA ligase activity
KUI_0598	COG0825	malonyl-CoA metabolic process
KUI_0599	COG0037	tRNA processing
KUI_0606	COG4178	(ABC) transporter
KUI_0610	COG1666	GTP binding
KUI_0611	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KUI_0613	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KUI_0614	COG1049	propionate catabolic process, 2-methylcitrate cycle
KUI_0617	COG0180	Tryptophanyl-tRNA synthetase
KUI_0618	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
KUI_0619	COG0671	phosphoesterase, PA-phosphatase related
KUI_0623	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KUI_0625	COG0187	DNA topoisomerase II activity
KUI_0629	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KUI_0630	COG0425	Belongs to the sulfur carrier protein TusA family
KUI_0631	COG0228	four-way junction DNA binding
KUI_0632	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KUI_0633	COG0336	Belongs to the RNA methyltransferase TrmD family
KUI_0634	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KUI_0636	COG1104	cysteine desulfurase activity
KUI_0637	COG0822	iron-sulfur transferase activity
KUI_0638	COG0316	Belongs to the HesB IscA family
KUI_0639	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KUI_0640	COG0443	Heat shock 70 kDa protein
KUI_0641	COG0633	Ferredoxin
KUI_0646	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KUI_0647	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KUI_0648	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KUI_0651	COG1136	(ABC) transporter
KUI_0652	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KUI_0653	COG0084	hydrolase, TatD family'
KUI_0655	COG0613	PHP domain protein
KUI_0657	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KUI_0658	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KUI_0659	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KUI_0660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KUI_0661	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KUI_0662	COG0072	phenylalanine-tRNA ligase activity
KUI_0662	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KUI_0663	COG0776	regulation of translation
KUI_0665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KUI_0666	COG1304	FMN binding
KUI_0667	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KUI_0669	COG0210	DNA helicase
KUI_0671	COG1610	YqeY-like protein
KUI_0673	COG1686	Belongs to the peptidase S11 family
KUI_0674	COG0047	phosphoribosylformylglycinamidine synthase activity
KUI_0674	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KUI_0677	COG0519	Catalyzes the synthesis of GMP from XMP
KUI_0677	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KUI_0685	COG4145	pantothenate transmembrane transporter activity
KUI_0686	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KUI_0687	COG4166	transmembrane transport
KUI_0691	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KUI_0697	COG1132	(ABC) transporter
KUI_0698	COG1132	(ABC) transporter
KUI_0699	COG0786	glutamate:sodium symporter activity
KUI_0702	COG0280	phosphate acetyltransferase
KUI_0702	COG0281	malic enzyme
KUI_0703	COG0567	Dehydrogenase, E1 component
KUI_0704	COG0508	dehydrogenase complex catalyzes the overall conversion of
KUI_0705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KUI_0706	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KUI_0710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KUI_0711	COG1758	RNA polymerase activity
KUI_0712	COG0194	GDP metabolic process
KUI_0713	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KUI_0714	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KUI_0719	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KUI_0721	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KUI_0722	COG3842	ATPase activity
KUI_0723	COG1176	ABC-type spermidine putrescine transport system, permease component I
KUI_0724	COG1177	transmembrane transport
KUI_0725	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KUI_0726	COG0704	Plays a role in the regulation of phosphate uptake
KUI_0727	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
KUI_0728	COG1643	Atp-dependent helicase
KUI_0731	COG1132	(ABC) transporter
KUI_0732	COG1530	ribonuclease E activity
KUI_0733	COG0302	gtp cyclohydrolase
KUI_0745	COG2833	Protein of unknown function (DUF455)
KUI_0746	COG4178	(ABC) transporter
KUI_0747	COG2153	protein acetylation
KUI_0749	COG0730	response to heat
KUI_0750	COG0557	exoribonuclease II activity
KUI_0751	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KUI_0752	COG0626	cystathionine gamma-synthase activity
KUI_0753	COG0776	regulation of translation
KUI_0755	COG0842	Transport permease protein
KUI_0755	COG1129	ABC transporter
KUI_0756	COG0842	Transport permease protein
KUI_0759	COG0137	argininosuccinate synthase activity
KUI_0760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KUI_0762	COG0268	Binds directly to 16S ribosomal RNA
KUI_0763	COG0728	peptidoglycan biosynthetic process
KUI_0764	COG0563	adenylate kinase activity
KUI_0765	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KUI_0766	COG2835	tetraacyldisaccharide 4'-kinase activity
KUI_0767	COG1663	tetraacyldisaccharide 4'-kinase activity
KUI_0768	COG1570	exodeoxyribonuclease VII activity
KUI_0769	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KUI_0774	COG0411	ABC transporter
KUI_0775	COG0410	ABC transporter
KUI_0776	COG1999	signal sequence binding
KUI_0777	COG0339	signal peptide processing
KUI_0778	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KUI_0782	COG0508	dehydrogenase complex catalyzes the overall conversion of
KUI_0783	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KUI_0784	COG3038	cytochrome b561
KUI_0785	COG0285	dihydrofolate synthase activity
KUI_0787	COG1286	toxin biosynthetic process
KUI_0792	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KUI_0793	COG0024	Methionine aminopeptidase
KUI_0794	COG0052	Belongs to the universal ribosomal protein uS2 family
KUI_0795	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KUI_0796	COG0528	UMP kinase activity
KUI_0797	COG0233	cytoplasmic translational termination
KUI_0798	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KUI_0799	COG0575	Belongs to the CDS family
KUI_0800	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KUI_0801	COG0750	zinc metalloprotease
KUI_0804	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KUI_0805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KUI_0806	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KUI_0807	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KUI_0808	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KUI_0810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KUI_0811	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KUI_0815	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KUI_0817	COG2914	Belongs to the UPF0125 (RnfH) family
KUI_0819	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KUI_0820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KUI_0821	COG0470	DNA polymerase III
KUI_0822	COG0084	hydrolase, TatD family'
KUI_0825	COG2212	antiporter activity
KUI_0826	COG1863	multisubunit Na H antiporter MnhE subunit
KUI_0827	COG0651	ATP synthesis coupled electron transport
KUI_0828	COG1006	Multisubunit Na H antiporter MnhC subunit
KUI_0829	COG2111	Na H antiporter
KUI_0829	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KUI_0834	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KUI_0835	COG0778	Nitroreductase
KUI_0841	COG0697	spore germination
KUI_0843	COG3181	Tripartite tricarboxylate transporter family receptor
KUI_0845	COG0708	Exodeoxyribonuclease III
KUI_0847	COG1187	pseudouridine synthase activity
KUI_0849	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KUI_0849	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KUI_0850	COG0165	Argininosuccinate lyase
KUI_0851	COG0859	PFAM glycosyl transferase family 9
KUI_0852	COG2137	regulation of response to DNA damage stimulus
KUI_0853	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KUI_0856	COG0556	nucleotide-excision repair
KUI_0858	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KUI_0862	COG0628	permease
KUI_0867	COG2171	N-acyltransferase activity
KUI_0868	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KUI_0869	COG2890	protein-(glutamine-N5) methyltransferase activity
KUI_0872	COG4120	Belongs to the binding-protein-dependent transport system permease family
KUI_0874	COG0101	tRNA pseudouridine synthase activity
KUI_0875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KUI_0876	COG0473	3-isopropylmalate dehydrogenase activity
KUI_0877	COG0066	3-isopropylmalate dehydratase activity
KUI_0878	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KUI_0880	COG1295	ribonuclease BN
KUI_0881	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KUI_0882	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KUI_0883	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KUI_0884	COG0038	chloride channel
KUI_0885	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KUI_0888	COG2086	electron transfer activity
KUI_0890	COG0322	excinuclease ABC activity
KUI_0891	COG1472	Belongs to the glycosyl hydrolase 3 family
KUI_0892	COG0736	holo-[acyl-carrier-protein] synthase activity
KUI_0893	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KUI_0894	COG1162	GTPase activity
KUI_0895	COG0335	large ribosomal subunit rRNA binding
KUI_0901	COG4964	Belongs to the GSP D family
KUI_0907	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KUI_0912	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KUI_0914	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KUI_0915	COG0330	HflC and HflK could
KUI_0916	COG0330	HflC and HflK could
KUI_0917	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KUI_0918	COG1923	regulation of RNA biosynthetic process
KUI_0919	COG1160	GTP binding
KUI_0920	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KUI_0921	COG2976	Protein conserved in bacteria
KUI_0922	COG0124	histidyl-tRNA synthetase
KUI_0923	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KUI_0925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KUI_0926	COG0105	UTP biosynthetic process
KUI_0927	COG0525	valine-tRNA ligase activity
KUI_0929	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KUI_0933	COG0181	hydroxymethylbilane synthase activity
KUI_0934	COG0861	Integral membrane protein TerC family
KUI_0935	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KUI_0936	COG0045	succinate-CoA ligase (ADP-forming) activity
KUI_0938	COG0405	Gamma-glutamyltransferase
KUI_0940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KUI_0942	COG4942	peptidase
KUI_0943	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KUI_0944	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KUI_0945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KUI_0946	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KUI_0947	COG2252	PERMEase
KUI_0949	COG0488	(ABC) transporter
KUI_0950	COG1619	proteins homologs of microcin C7 resistance protein MccF
KUI_0951	COG0590	tRNA wobble adenosine to inosine editing
KUI_0957	COG1629	transport
KUI_0957	COG4206	TonB-dependent receptor
KUI_0958	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KUI_0963	COG0523	cobalamin synthesis protein
KUI_0968	COG1840	ABC-type Fe3 transport system, periplasmic component
KUI_0972	COG0372	Belongs to the citrate synthase family
KUI_0973	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KUI_0974	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KUI_0975	COG1053	succinate dehydrogenase
KUI_0977	COG2009	succinate dehydrogenase
KUI_0978	COG0039	L-malate dehydrogenase activity
KUI_0985	COG3209	COG3209 Rhs family protein
KUI_0988	COG3209	COG3209 Rhs family protein
KUI_0990	COG3209	COG3209 Rhs family protein
KUI_0997	COG3501	Rhs element vgr protein
KUI_1000	COG3501	Rhs element vgr protein
KUI_1002	COG3501	Rhs element vgr protein
KUI_1005	COG0542	response to heat
KUI_1007	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KUI_1008	COG0148	phosphopyruvate hydratase activity
KUI_1009	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KUI_1010	COG0504	CTP synthase activity
KUI_1012	COG0583	DNA-binding transcription factor activity
KUI_1013	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KUI_1015	COG1012	belongs to the aldehyde dehydrogenase family
KUI_1016	COG2423	ornithine cyclodeaminase activity
KUI_1017	COG1301	dicarboxylic acid transport
KUI_1018	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KUI_1019	COG5383	Protein conserved in bacteria
KUI_1025	COG2841	Protein conserved in bacteria
KUI_1027	COG1629	transport
KUI_1027	COG4206	TonB-dependent receptor
KUI_1029	COG0748	coenzyme F420 binding
KUI_1033	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KUI_1034	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KUI_1035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KUI_1036	COG0195	Participates in both transcription termination and antitermination
KUI_1036	COG2251	uridine kinase activity
KUI_1037	COG0779	Required for maturation of 30S ribosomal subunits
KUI_1038	COG1187	pseudouridine synthase activity
KUI_1039	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KUI_1043	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KUI_1045	COG0210	DNA helicase
KUI_1046	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KUI_1046	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KUI_1047	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KUI_1048	COG0196	riboflavin kinase activity
KUI_1049	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KUI_1051	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KUI_1052	COG0586	Pfam SNARE associated Golgi protein
KUI_1053	COG0756	dUTP diphosphatase activity
KUI_1054	COG1629	transport
KUI_1054	COG4771	TonB-dependent receptor
KUI_1057	COG0542	response to heat
KUI_1058	COG1278	Cold shock
KUI_1060	COG0583	DNA-binding transcription factor activity
KUI_1061	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KUI_1063	COG1840	ABC-type Fe3 transport system, periplasmic component
KUI_1064	COG1178	ABC-type Fe3 transport system permease component
KUI_1065	COG3842	ATPase activity
KUI_1068	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KUI_1069	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KUI_1070	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KUI_1071	COG1561	YicC-like family, N-terminal region
KUI_1072	COG0305	Participates in initiation and elongation during chromosome replication
KUI_1073	COG0359	binds to the 23S rRNA
KUI_1074	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KUI_1076	COG0360	Binds together with S18 to 16S ribosomal RNA
KUI_1077	COG1469	GTP cyclohydrolase I activity
KUI_1078	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KUI_1079	COG0142	geranyltranstransferase activity
KUI_1080	COG1722	exodeoxyribonuclease VII activity
KUI_1082	COG1228	amidohydrolase
KUI_1083	COG2986	histidine ammonia-lyase
KUI_1084	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KUI_1085	COG2188	Transcriptional regulator
KUI_1088	COG0501	Belongs to the peptidase M48B family
KUI_1089	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KUI_1089	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KUI_1090	COG1611	Belongs to the LOG family
KUI_1091	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KUI_1093	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KUI_1094	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KUI_1096	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KUI_1097	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KUI_1099	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KUI_1100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KUI_1101	COG0740	serine-type endopeptidase activity
KUI_1102	COG0544	peptidyl-prolyl cis-trans isomerase activity
KUI_1105	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KUI_1106	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KUI_1114	COG3451	type IV secretory pathway VirB4
KUI_1164	COG0582	viral genome integration into host DNA
KUI_1168	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KUI_1170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KUI_1171	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
KUI_1177	COG0577	efflux transmembrane transporter activity
KUI_1177	COG1136	(ABC) transporter
KUI_1179	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KUI_1183	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KUI_1185	COG1185	polyribonucleotide nucleotidyltransferase activity
KUI_1186	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KUI_1188	COG1115	amino acid carrier protein
KUI_1190	COG0440	acetolactate synthase activity
KUI_1191	COG0028	Belongs to the TPP enzyme family
KUI_1192	COG3022	response to hydroperoxide
KUI_1193	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KUI_1194	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KUI_1196	COG1674	ftsk spoiiie
KUI_1197	COG0492	ferredoxin-NADP+ reductase activity
KUI_1199	COG2707	UPF0756 membrane protein
KUI_1201	COG2855	membrane
KUI_1204	COG0484	heat shock protein binding
KUI_1205	COG0443	Heat shock 70 kDa protein
KUI_1206	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KUI_1207	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KUI_1208	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KUI_1209	COG1420	regulation of RNA biosynthetic process
KUI_1210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KUI_1211	COG0497	DNA recombination
KUI_1212	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KUI_1213	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KUI_1214	COG0735	belongs to the Fur family
KUI_1215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KUI_1217	COG1230	cation diffusion facilitator family transporter
KUI_1219	COG2837	iron assimilation
KUI_1221	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KUI_1225	COG0248	Ppx GppA phosphatase
KUI_1227	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KUI_1228	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KUI_1229	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KUI_1230	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KUI_1231	COG1534	Rna-binding protein
KUI_1232	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KUI_1233	COG2233	PERMEase
KUI_1235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KUI_1236	COG0505	Belongs to the CarA family
KUI_1237	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KUI_1240	COG1074	ATP-dependent DNA helicase activity
KUI_1244	COG3384	dioxygenase
KUI_1250	COG4974	Belongs to the 'phage' integrase family
KUI_1251	COG0802	atpase or kinase
KUI_1252	COG0860	N-Acetylmuramoyl-L-alanine amidase
KUI_1253	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KUI_1254	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KUI_1255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KUI_1256	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KUI_1257	COG0617	tRNA 3'-terminal CCA addition
KUI_1258	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KUI_1261	COG3258	Cytochrome c
KUI_1268	COG0167	dihydroorotate dehydrogenase activity
KUI_1270	COG0513	Belongs to the DEAD box helicase family
KUI_1274	COG0138	bifunctional purine biosynthesis protein purh
KUI_1275	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KUI_1276	COG0632	four-way junction helicase activity
KUI_1282	COG2022	thiamine diphosphate biosynthetic process
KUI_1289	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KUI_1289	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KUI_1290	COG2239	Acts as a magnesium transporter
KUI_1291	COG0653	protein targeting
KUI_1292	COG0739	heme binding
KUI_1294	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KUI_1295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KUI_1297	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KUI_1298	COG1181	Belongs to the D-alanine--D-alanine ligase family
KUI_1299	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KUI_1300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KUI_1301	COG0772	Belongs to the SEDS family
KUI_1302	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KUI_1303	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KUI_1304	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KUI_1307	COG0275	rRNA processing
KUI_1308	COG2001	Belongs to the MraZ family
KUI_1309	COG0753	catalase activity
KUI_1310	COG0752	glycyl-tRNA synthetase alpha subunit
KUI_1311	COG0751	glycine-tRNA ligase activity
KUI_1312	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KUI_1315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KUI_1316	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KUI_1317	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KUI_1321	COG0745	RESPONSE REGULATOR receiver
KUI_1322	COG2205	protein histidine kinase activity
KUI_1323	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KUI_1324	COG0850	regulation of cytokinetic process
KUI_1325	COG2894	cell division
KUI_1326	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KUI_1327	COG0488	(ABC) transporter
KUI_1330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KUI_1331	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KUI_1332	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KUI_1333	COG0259	pyridoxamine-phosphate oxidase activity
KUI_1334	COG1858	cytochrome C peroxidase
KUI_1335	COG0009	L-threonylcarbamoyladenylate synthase
KUI_1336	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KUI_1337	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KUI_1338	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KUI_1340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KUI_1341	COG0126	phosphoglycerate kinase activity
KUI_1342	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KUI_1343	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KUI_1344	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KUI_1347	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KUI_1351	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KUI_1352	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KUI_1354	COG1862	Preprotein translocase
KUI_1355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KUI_1356	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KUI_1357	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KUI_1358	COG1702	phosphate starvation-inducible protein PhoH
KUI_1359	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KUI_1360	COG4535	Mg2 and Co2 transporter CorC
KUI_1365	COG4172	Belongs to the ABC transporter superfamily
KUI_1366	COG0747	negative chemotaxis
KUI_1367	COG0601	transmembrane transport
KUI_1368	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KUI_1372	COG0328	RNA-DNA hybrid ribonuclease activity
KUI_1374	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KUI_1375	COG0741	lytic transglycosylase activity
KUI_1375	COG1388	LysM domain
KUI_1379	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KUI_1379	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KUI_1380	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KUI_1381	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KUI_1382	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KUI_1383	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KUI_1384	COG0316	Belongs to the HesB IscA family
KUI_1386	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KUI_1387	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KUI_1388	COG0312	modulator of DNA gyrase
KUI_1390	COG0400	carboxylic ester hydrolase activity
KUI_1391	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KUI_1396	COG2264	protein methyltransferase activity
KUI_1398	COG0511	ligase activity, forming carbon-carbon bonds
KUI_1399	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KUI_1400	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
KUI_1402	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KUI_1405	COG0540	Belongs to the ATCase OTCase family
KUI_1406	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KUI_1408	COG1773	rubredoxin
KUI_1409	COG0352	thiamine-phosphate diphosphorylase activity
KUI_1410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KUI_1411	COG0513	Belongs to the DEAD box helicase family
KUI_1413	COG0617	tRNA 3'-terminal CCA addition
KUI_1417	COG3209	COG3209 Rhs family protein
KUI_1419	COG3209	COG3209 Rhs family protein
KUI_1423	COG2879	small protein
KUI_1424	COG1966	Carbon starvation protein
KUI_1427	COG3180	Ammonia monooxygenase
KUI_1431	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KUI_1432	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KUI_1433	COG1560	Kdo2-lipid A biosynthetic process
KUI_1434	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KUI_1435	COG0708	Exodeoxyribonuclease III
KUI_1437	COG2223	nitrite transmembrane transporter activity
KUI_1439	COG3245	cytochrome
KUI_1442	COG1982	Orn Lys Arg decarboxylase major
KUI_1447	COG4566	intracellular signal transduction
KUI_1451	COG1858	cytochrome C peroxidase
KUI_1462	COG2969	positive regulation of protein catabolic process
KUI_1463	COG0625	glutathione transferase activity
KUI_1464	COG2857	Cytochrome c1
KUI_1465	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KUI_1466	COG0723	plastoquinol--plastocyanin reductase activity
KUI_1467	COG1970	mechanosensitive ion channel activity
KUI_1468	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KUI_1469	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KUI_1470	COG0805	protein transport
KUI_1471	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KUI_1472	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KUI_1473	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KUI_1474	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KUI_1476	COG0842	Transport permease protein
KUI_1477	COG1131	(ABC) transporter
KUI_1479	COG2853	Lipoprotein
KUI_1480	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KUI_1481	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KUI_1482	COG1127	ABC transporter
KUI_1483	COG0758	DNA mediated transformation
KUI_1484	COG0242	peptide deformylase activity
KUI_1485	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KUI_1486	COG1253	flavin adenine dinucleotide binding
KUI_1487	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KUI_1491	COG0629	single-stranded DNA binding
KUI_1492	COG2814	Major facilitator Superfamily
KUI_1495	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KUI_1497	COG0019	diaminopimelate decarboxylase activity
KUI_1499	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KUI_1500	COG1333	cytochrome c biogenesis protein
KUI_1502	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KUI_1505	COG4232	protein-disulfide reductase activity
KUI_1507	COG0786	glutamate:sodium symporter activity
KUI_1508	COG0010	Belongs to the arginase family
KUI_1511	COG0203	ribosomal protein L17
KUI_1512	COG0202	RNA polymerase activity
KUI_1513	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KUI_1514	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KUI_1515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KUI_1517	COG0201	protein transport
KUI_1518	COG0200	Binds to the 23S rRNA
KUI_1519	COG1841	ribosomal large subunit assembly
KUI_1520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KUI_1521	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KUI_1522	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KUI_1523	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KUI_1524	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KUI_1525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KUI_1526	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KUI_1527	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KUI_1528	COG2056	Na+-H+ antiporter family
KUI_1529	COG2056	Na+-H+ antiporter family
KUI_1530	COG2132	Multicopper oxidase
KUI_1531	COG1999	signal sequence binding
KUI_1533	COG2217	Heavy metal translocating P-type atpase
KUI_1537	COG0625	glutathione transferase activity
KUI_1539	COG1373	ATPase (AAA superfamily
KUI_1545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KUI_1546	COG0255	Belongs to the universal ribosomal protein uL29 family
KUI_1547	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KUI_1548	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KUI_1549	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KUI_1550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KUI_1551	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KUI_1552	COG0089	rRNA binding
KUI_1553	COG0088	Forms part of the polypeptide exit tunnel
KUI_1554	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KUI_1555	COG1322	Protein conserved in bacteria
KUI_1558	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KUI_1562	COG0051	transcription antitermination factor activity, RNA binding
KUI_1563	COG1132	(ABC) transporter
KUI_1565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KUI_1566	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KUI_1567	COG0049	tRNA binding
KUI_1568	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KUI_1572	COG2301	Belongs to the HpcH HpaI aldolase family
KUI_1574	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
KUI_1575	COG1960	acyl-CoA dehydrogenase activity
KUI_1580	COG3313	Fe-S protein
KUI_1581	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KUI_1582	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KUI_1583	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KUI_1586	COG0010	Belongs to the arginase family
KUI_1587	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KUI_1588	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KUI_1589	COG0085	RNA polymerase activity
KUI_1590	COG0222	ribosome binding
KUI_1591	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KUI_1592	COG0081	regulation of translation
KUI_1593	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KUI_1595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KUI_1597	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KUI_1602	COG1475	DNA binding
KUI_1603	COG1192	Involved in chromosome partitioning
KUI_1604	COG0357	Ribosomal RNA small subunit methyltransferase G
KUI_1605	COG0445	tRNA wobble uridine modification
KUI_1606	COG0537	adenosine 5'-monophosphoramidase activity
KUI_1608	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KUI_1609	COG0594	ribonuclease P activity
KUI_1610	COG0230	Belongs to the bacterial ribosomal protein bL34 family