locus-tag	class	description
KIH39_00200	COG2204	response regulator
KIH39_00270	COG3335	DDE superfamily endonuclease
KIH39_00280	COG3781	membrane
KIH39_00290	COG3781	membrane
KIH39_00310	COG1064	alcohol dehydrogenase
KIH39_00320	COG3119	arylsulfatase activity
KIH39_00350	COG3852	Histidine kinase
KIH39_00360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KIH39_00365	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KIH39_00375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KIH39_00390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KIH39_00405	COG1028	Short-chain dehydrogenase reductase Sdr
KIH39_00435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KIH39_00440	COG0314	molybdopterin synthase activity
KIH39_00445	COG0277	FAD linked oxidase domain protein
KIH39_00450	COG0302	gtp cyclohydrolase
KIH39_00460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KIH39_00525	COG1131	(ABC) transporter
KIH39_00580	COG0135	phosphoribosylanthranilate isomerase activity
KIH39_00585	COG0307	riboflavin synthase, alpha
KIH39_00590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KIH39_00600	COG2975	iron-sulfur cluster assembly
KIH39_00605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KIH39_00610	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KIH39_00615	COG0375	protein maturation
KIH39_00620	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KIH39_00625	COG0298	carbon dioxide binding
KIH39_00635	COG0309	Hydrogenase expression formation protein (HypE)
KIH39_00665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KIH39_00670	COG0515	serine threonine protein kinase
KIH39_00675	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KIH39_00680	COG0126	phosphoglycerate kinase activity
KIH39_00685	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KIH39_00730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_00795	COG3118	belongs to the thioredoxin family
KIH39_00805	COG2814	Major facilitator Superfamily
KIH39_00850	COG0440	acetolactate synthase activity
KIH39_00870	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KIH39_00875	COG0305	Participates in initiation and elongation during chromosome replication
KIH39_00880	COG0359	binds to the 23S rRNA
KIH39_00885	COG0629	single-stranded DNA binding
KIH39_00890	COG0360	Binds together with S18 to 16S ribosomal RNA
KIH39_00900	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KIH39_00910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KIH39_00915	COG1193	negative regulation of DNA recombination
KIH39_00945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KIH39_00945	COG0321	lipoyl(octanoyl) transferase activity
KIH39_00950	COG1834	amidinotransferase
KIH39_00960	COG1131	(ABC) transporter
KIH39_00990	COG2205	protein histidine kinase activity
KIH39_00995	COG2271	Major facilitator Superfamily
KIH39_01000	COG2815	serine threonine protein kinase
KIH39_01000	COG0515	serine threonine protein kinase
KIH39_01015	COG0673	inositol 2-dehydrogenase activity
KIH39_01070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KIH39_01080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KIH39_01090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KIH39_01105	COG0515	serine threonine protein kinase
KIH39_01105	COG2815	serine threonine protein kinase
KIH39_01115	COG0745	RESPONSE REGULATOR receiver
KIH39_01130	COG5002	protein histidine kinase activity
KIH39_01135	COG0573	inorganic phosphate transmembrane transporter activity
KIH39_01155	COG0546	phosphoglycolate phosphatase activity
KIH39_01165	COG0459	protein refolding
KIH39_01170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KIH39_01175	COG0459	protein refolding
KIH39_01180	COG0484	heat shock protein binding
KIH39_01195	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KIH39_01205	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KIH39_01215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KIH39_01220	COG1872	DUF167
KIH39_01235	COG1136	(ABC) transporter
KIH39_01240	COG0484	heat shock protein binding
KIH39_01255	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KIH39_01260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KIH39_01275	COG1714	RDD family
KIH39_01285	COG0848	biopolymer transport protein
KIH39_01325	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KIH39_01345	COG0501	Belongs to the peptidase M48B family
KIH39_01350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KIH39_01360	COG2815	serine threonine protein kinase
KIH39_01360	COG0515	serine threonine protein kinase
KIH39_01370	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KIH39_01380	COG0515	serine threonine protein kinase
KIH39_01380	COG2815	serine threonine protein kinase
KIH39_01390	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KIH39_01395	COG0724	RNA recognition motif
KIH39_01400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KIH39_01410	COG5002	protein histidine kinase activity
KIH39_01415	COG2204	response regulator
KIH39_01430	COG0542	response to heat
KIH39_01435	COG2304	oxidoreductase activity
KIH39_01455	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KIH39_01460	COG0586	Pfam SNARE associated Golgi protein
KIH39_01470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KIH39_01475	COG0156	8-amino-7-oxononanoate synthase activity
KIH39_01480	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KIH39_01535	COG3119	arylsulfatase activity
KIH39_01560	COG0515	serine threonine protein kinase
KIH39_01580	COG2815	serine threonine protein kinase
KIH39_01580	COG0515	serine threonine protein kinase
KIH39_01620	COG0528	UMP kinase activity
KIH39_01660	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KIH39_01665	COG0531	amino acid
KIH39_01710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KIH39_01715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KIH39_01720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KIH39_01725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KIH39_01730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KIH39_01740	COG4208	sulfate ABC transporter
KIH39_01755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KIH39_01770	COG1396	sequence-specific DNA binding
KIH39_01785	COG1082	Xylose isomerase domain protein TIM barrel
KIH39_01810	COG0515	serine threonine protein kinase
KIH39_01810	COG2815	serine threonine protein kinase
KIH39_01815	COG0515	serine threonine protein kinase
KIH39_01815	COG2815	serine threonine protein kinase
KIH39_01820	COG1716	ATPase activity
KIH39_01820	COG1131	(ABC) transporter
KIH39_01820	COG0842	Transport permease protein
KIH39_01860	COG0515	serine threonine protein kinase
KIH39_01970	COG0346	lactoylglutathione lyase activity
KIH39_02070	COG0457	Tetratricopeptide repeat
KIH39_02070	COG0705	Rhomboid family
KIH39_02125	COG2226	methyltransferase
KIH39_02130	COG1131	(ABC) transporter
KIH39_02150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KIH39_02160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KIH39_02170	COG0606	chelatase, subunit chli
KIH39_02195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KIH39_02220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KIH39_02225	COG1716	ATPase activity
KIH39_02230	COG1381	Involved in DNA repair and RecF pathway recombination
KIH39_02245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KIH39_02250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KIH39_02260	COG0443	Heat shock 70 kDa protein
KIH39_02270	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KIH39_02285	COG1104	cysteine desulfurase activity
KIH39_02310	COG0742	ribosomal rna small subunit methyltransferase
KIH39_02320	COG0617	tRNA 3'-terminal CCA addition
KIH39_02325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KIH39_02330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KIH39_02340	COG0515	serine threonine protein kinase
KIH39_02340	COG2815	serine threonine protein kinase
KIH39_02350	COG2027	D-alanyl-D-alanine carboxypeptidase
KIH39_02360	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KIH39_02365	COG0459	protein refolding
KIH39_02370	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KIH39_02375	COG1690	Belongs to the RtcB family
KIH39_02380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KIH39_02390	COG0457	Tetratricopeptide repeat
KIH39_02390	COG0515	serine threonine protein kinase
KIH39_02400	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
KIH39_02430	COG2379	hydroxypyruvate reductase
KIH39_02435	COG0163	prenyltransferase activity
KIH39_02450	COG0693	protein deglycase activity
KIH39_02455	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KIH39_02475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KIH39_02480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KIH39_02485	COG1940	carbohydrate kinase activity
KIH39_02495	COG2353	YceI-like domain
KIH39_02500	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KIH39_02510	COG0166	Belongs to the GPI family
KIH39_02520	COG0750	zinc metalloprotease
KIH39_02525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KIH39_02530	COG0515	serine threonine protein kinase
KIH39_02540	COG0347	Belongs to the P(II) protein family
KIH39_02545	COG1028	Short-chain dehydrogenase reductase Sdr
KIH39_02565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KIH39_02595	COG0443	Heat shock 70 kDa protein
KIH39_02615	COG0363	glucosamine-6-phosphate deaminase activity
KIH39_02620	COG2022	thiamine diphosphate biosynthetic process
KIH39_02625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KIH39_02635	COG1131	(ABC) transporter
KIH39_02640	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KIH39_02645	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KIH39_02665	COG2323	membrane
KIH39_02675	COG0228	four-way junction DNA binding
KIH39_02680	COG0336	Belongs to the RNA methyltransferase TrmD family
KIH39_02685	COG0335	large ribosomal subunit rRNA binding
KIH39_02690	COG0792	nuclease activity
KIH39_02695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KIH39_02700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KIH39_02705	COG4581	dead DEAH box helicase
KIH39_02725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KIH39_02730	COG2062	phosphohistidine phosphatase, SixA
KIH39_02740	COG1331	Highly conserved protein containing a thioredoxin domain
KIH39_02750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KIH39_02755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KIH39_02770	COG0848	biopolymer transport protein
KIH39_02780	COG1215	transferase activity, transferring glycosyl groups
KIH39_02805	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KIH39_02815	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KIH39_02820	COG1126	abc transporter atp-binding protein
KIH39_02840	COG5002	protein histidine kinase activity
KIH39_02845	COG0745	RESPONSE REGULATOR receiver
KIH39_02850	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KIH39_02860	COG0174	glutamine synthetase
KIH39_02875	COG0004	ammonium transporteR
KIH39_02880	COG0347	Belongs to the P(II) protein family
KIH39_02890	COG0776	regulation of translation
KIH39_02900	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KIH39_02905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KIH39_02915	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KIH39_02935	COG1122	ATPase activity
KIH39_02965	COG0463	Glycosyl transferase, family 2
KIH39_02970	COG0047	phosphoribosylformylglycinamidine synthase activity
KIH39_02980	COG0018	arginyl-trna synthetase
KIH39_02990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KIH39_02995	COG0631	protein serine/threonine phosphatase activity
KIH39_03000	COG0438	transferase activity, transferring glycosyl groups
KIH39_03020	COG0537	adenosine 5'-monophosphoramidase activity
KIH39_03035	COG2815	serine threonine protein kinase
KIH39_03035	COG0515	serine threonine protein kinase
KIH39_03055	COG0300	oxidoreductase activity
KIH39_03065	COG0802	atpase or kinase
KIH39_03080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KIH39_03090	COG1607	acyl-coa hydrolase
KIH39_03095	COG1172	Belongs to the binding-protein-dependent transport system permease family
KIH39_03135	COG0442	prolyl-tRNA aminoacylation
KIH39_03150	COG1477	protein flavinylation
KIH39_03180	COG0577	efflux transmembrane transporter activity
KIH39_03180	COG1136	(ABC) transporter
KIH39_03185	COG1136	(ABC) transporter
KIH39_03185	COG0577	efflux transmembrane transporter activity
KIH39_03190	COG0488	(ABC) transporter
KIH39_03205	COG0714	Associated with various cellular activities
KIH39_03230	COG3046	protein related to deoxyribodipyrimidine photolyase
KIH39_03235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KIH39_03250	COG2815	serine threonine protein kinase
KIH39_03250	COG0515	serine threonine protein kinase
KIH39_03260	COG0436	Aminotransferase
KIH39_03280	COG0300	oxidoreductase activity
KIH39_03310	COG1082	Xylose isomerase domain protein TIM barrel
KIH39_03320	COG1555	photosystem II stabilization
KIH39_03320	COG1596	polysaccharide export
KIH39_03370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KIH39_03380	COG1921	L-seryl-tRNASec selenium transferase activity
KIH39_03390	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KIH39_03395	COG0706	membrane insertase activity
KIH39_03395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_03400	COG4912	Dna alkylation repair
KIH39_03410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KIH39_03420	COG2197	response regulator
KIH39_03425	COG4585	Histidine kinase
KIH39_03430	COG0784	Response regulator, receiver
KIH39_03430	COG4191	Histidine kinase
KIH39_03435	COG3437	response regulator, receiver
KIH39_03450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KIH39_03455	COG0438	transferase activity, transferring glycosyl groups
KIH39_03470	COG0859	PFAM glycosyl transferase family 9
KIH39_03475	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KIH39_03475	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KIH39_03505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KIH39_03510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KIH39_03535	COG1090	epimerase
KIH39_03550	COG0574	Belongs to the PEP-utilizing enzyme family
KIH39_03550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KIH39_03570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_03575	COG0750	zinc metalloprotease
KIH39_03580	COG1024	Enoyl-CoA hydratase
KIH39_03580	COG1250	3-hydroxyacyl-CoA dehydrogenase
KIH39_03595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KIH39_03600	COG0183	Belongs to the thiolase family
KIH39_03605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KIH39_03615	COG1061	Type III restriction enzyme res subunit
KIH39_03625	COG2814	Major facilitator Superfamily
KIH39_03645	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KIH39_03650	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KIH39_03655	COG4968	Prepilin-type N-terminal cleavage methylation domain
KIH39_03675	COG0275	rRNA processing
KIH39_03680	COG1234	tRNA 3'-trailer cleavage
KIH39_03695	COG0724	RNA recognition motif
KIH39_03705	COG0352	thiamine-phosphate diphosphorylase activity
KIH39_03730	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KIH39_03735	COG0187	DNA topoisomerase II activity
KIH39_03745	COG0598	Magnesium transport protein CorA
KIH39_03775	COG0504	CTP synthase activity
KIH39_03785	COG0483	inositol monophosphate 1-phosphatase activity
KIH39_03790	COG1940	carbohydrate kinase activity
KIH39_03805	COG1091	dTDP-4-dehydrorhamnose reductase activity
KIH39_03830	COG1595	DNA-templated transcription, initiation
KIH39_03850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KIH39_03865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KIH39_03880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KIH39_03885	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KIH39_03895	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KIH39_03900	COG0009	L-threonylcarbamoyladenylate synthase
KIH39_03915	COG0463	Glycosyl transferase, family 2
KIH39_03930	COG0438	transferase activity, transferring glycosyl groups
KIH39_03935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_03955	COG2719	SpoVR family
KIH39_03960	COG2718	Belongs to the UPF0229 family
KIH39_03975	COG2766	serine protein kinase
KIH39_03985	COG0438	transferase activity, transferring glycosyl groups
KIH39_03990	COG0297	glycogen (starch) synthase activity
KIH39_03995	COG0673	inositol 2-dehydrogenase activity
KIH39_04015	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KIH39_04040	COG0824	Thioesterase
KIH39_04050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KIH39_04065	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KIH39_04070	COG1088	dTDP-glucose 4,6-dehydratase activity
KIH39_04080	COG0354	folic acid binding
KIH39_04090	COG3494	Protein of unknown function (DUF1009)
KIH39_04095	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KIH39_04120	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KIH39_04145	COG1331	Highly conserved protein containing a thioredoxin domain
KIH39_04165	COG0393	Putative heavy-metal-binding
KIH39_04185	COG2084	Dehydrogenase
KIH39_04190	COG0745	RESPONSE REGULATOR receiver
KIH39_04195	COG5002	protein histidine kinase activity
KIH39_04200	COG1058	Belongs to the CinA family
KIH39_04200	COG1546	Belongs to the CinA family
KIH39_04205	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KIH39_04230	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KIH39_04235	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KIH39_04240	COG0295	cytidine deaminase activity
KIH39_04300	COG0612	Peptidase, M16
KIH39_04340	COG0793	Belongs to the peptidase S41A family
KIH39_04345	COG0436	Aminotransferase
KIH39_04350	COG0515	serine threonine protein kinase
KIH39_04355	COG1012	belongs to the aldehyde dehydrogenase family
KIH39_04360	COG1082	Xylose isomerase domain protein TIM barrel
KIH39_04370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KIH39_04375	COG1045	serine acetyltransferase
KIH39_04390	COG1024	Enoyl-CoA hydratase
KIH39_04420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KIH39_04425	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KIH39_04430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KIH39_04435	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KIH39_04440	COG1643	Atp-dependent helicase
KIH39_04565	COG3458	cephalosporin-C deacetylase activity
KIH39_04570	COG1285	pathogenesis
KIH39_04585	COG5487	UPF0391 membrane protein
KIH39_04615	COG2897	thiosulfate sulfurtransferase activity
KIH39_04640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KIH39_04640	COG2207	Transcriptional regulator
KIH39_04765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KIH39_04815	COG1064	alcohol dehydrogenase
KIH39_04820	COG0084	hydrolase, TatD family'
KIH39_04825	COG1007	ATP synthesis coupled electron transport
KIH39_04835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KIH39_04840	COG0713	ATP synthesis coupled electron transport
KIH39_04845	COG0839	Belongs to the complex I subunit 6 family
KIH39_04850	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KIH39_04855	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KIH39_04860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KIH39_04875	COG2217	Heavy metal translocating P-type atpase
KIH39_04920	COG0437	4 iron, 4 sulfur cluster binding
KIH39_04930	COG0730	response to heat
KIH39_04965	COG0243	molybdopterin cofactor binding
KIH39_04980	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KIH39_04980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KIH39_05000	COG0515	serine threonine protein kinase
KIH39_05000	COG2815	serine threonine protein kinase
KIH39_05035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KIH39_05040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KIH39_05045	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KIH39_05050	COG0416	fatty acid biosynthetic process
KIH39_05055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KIH39_05065	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KIH39_05070	COG4956	integral membrane protein (PIN domain superfamily)
KIH39_05080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KIH39_05095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KIH39_05115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KIH39_05130	COG4191	Histidine kinase
KIH39_05135	COG2204	response regulator
KIH39_05165	COG1073	alpha beta
KIH39_05170	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KIH39_05175	COG0303	'Molybdopterin
KIH39_05185	COG1131	(ABC) transporter
KIH39_05195	COG0686	Belongs to the AlaDH PNT family
KIH39_05200	COG1570	exodeoxyribonuclease VII activity
KIH39_05215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KIH39_05225	COG1611	Belongs to the LOG family
KIH39_05235	COG0284	orotidine-5'-phosphate decarboxylase activity
KIH39_05260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KIH39_05280	COG2217	Heavy metal translocating P-type atpase
KIH39_05285	COG0657	acetylesterase activity
KIH39_05285	COG2755	lipolytic protein G-D-S-L family
KIH39_05295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KIH39_05300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KIH39_05305	COG0493	'glutamate synthase
KIH39_05305	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
KIH39_05310	COG0116	Belongs to the methyltransferase superfamily
KIH39_05310	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KIH39_05330	COG2814	Major facilitator Superfamily
KIH39_05335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KIH39_05340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KIH39_05340	COG0519	Catalyzes the synthesis of GMP from XMP
KIH39_05345	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KIH39_05360	COG0134	indole-3-glycerol-phosphate synthase activity
KIH39_05380	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KIH39_05405	COG0107	imidazoleglycerol-phosphate synthase activity
KIH39_05415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KIH39_05435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KIH39_05440	COG0318	PFAM AMP-dependent synthetase and ligase
KIH39_05445	COG0596	Alpha beta hydrolase
KIH39_05450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KIH39_05455	COG4221	oxidoreductase activity
KIH39_05455	COG0300	oxidoreductase activity
KIH39_05455	COG3321	synthase
KIH39_05455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KIH39_05460	COG0604	alcohol dehydrogenase
KIH39_05460	COG3321	synthase
KIH39_05460	COG0604	alcohol dehydrogenase
KIH39_05460	COG3321	synthase
KIH39_05465	COG2070	2-Nitropropane dioxygenase
KIH39_05465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KIH39_05470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KIH39_05475	COG1519	Transferase
KIH39_05480	COG0653	protein targeting
KIH39_05500	COG0746	molybdenum cofactor guanylyltransferase activity
KIH39_05515	COG0159	tryptophan synthase activity
KIH39_05520	COG0133	tryptophan synthase activity
KIH39_05525	COG0072	phenylalanine-tRNA ligase activity
KIH39_05525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KIH39_05530	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KIH39_05535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KIH39_05540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KIH39_05550	COG0343	queuine tRNA-ribosyltransferase activity
KIH39_05560	COG0202	RNA polymerase activity
KIH39_05570	COG0116	Belongs to the methyltransferase superfamily
KIH39_05580	COG2813	Specifically methylates the guanine in position
KIH39_05590	COG2010	Cytochrome c
KIH39_05600	COG0673	inositol 2-dehydrogenase activity
KIH39_05605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KIH39_05610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KIH39_05615	COG0701	Predicted permease
KIH39_05640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KIH39_05645	COG4636	protein conserved in cyanobacteria
KIH39_05650	COG0423	glycine-tRNA ligase activity
KIH39_05660	COG1132	(ABC) transporter
KIH39_05670	COG1215	transferase activity, transferring glycosyl groups
KIH39_05685	COG0714	Associated with various cellular activities
KIH39_05690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KIH39_05710	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KIH39_05730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KIH39_05775	COG1028	Short-chain dehydrogenase reductase Sdr
KIH39_05785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KIH39_05810	COG0322	excinuclease ABC activity
KIH39_05815	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
KIH39_05820	COG1702	phosphate starvation-inducible protein PhoH
KIH39_05825	COG0575	Belongs to the CDS family
KIH39_05830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KIH39_05835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KIH39_05840	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KIH39_05860	COG0142	geranyltranstransferase activity
KIH39_05875	COG0740	serine-type endopeptidase activity
KIH39_05880	COG0740	serine-type endopeptidase activity
KIH39_05885	COG0544	peptidyl-prolyl cis-trans isomerase activity
KIH39_05910	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KIH39_05925	COG1543	Belongs to the glycosyl hydrolase 57 family
KIH39_05930	COG0402	S-adenosylhomocysteine deaminase activity
KIH39_05935	COG2962	Rard protein
KIH39_05945	COG1028	Short-chain dehydrogenase reductase Sdr
KIH39_05985	COG1013	pyruvate-flavodoxin oxidoreductase activity
KIH39_05990	COG0674	pyruvate-flavodoxin oxidoreductase activity
KIH39_05990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KIH39_05995	COG1125	glycine betaine transport
KIH39_05995	COG0517	IMP dehydrogenase activity
KIH39_06010	COG0277	FAD linked oxidase domain protein
KIH39_06015	COG0277	FAD linked oxidase domain protein
KIH39_06020	COG0247	lactate metabolic process
KIH39_06025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KIH39_06035	COG0564	pseudouridine synthase activity
KIH39_06045	COG2382	esterase
KIH39_06050	COG0217	transcriptional regulatory protein
KIH39_06055	COG1032	radical SAM domain protein
KIH39_06065	COG2208	phosphoserine phosphatase activity
KIH39_06080	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
KIH39_06095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KIH39_06095	COG3320	Male sterility
KIH39_06110	COG0673	inositol 2-dehydrogenase activity
KIH39_06160	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KIH39_06180	COG1028	Short-chain dehydrogenase reductase Sdr
KIH39_06185	COG0515	serine threonine protein kinase
KIH39_06185	COG2815	serine threonine protein kinase
KIH39_06190	COG1368	sulfuric ester hydrolase activity
KIH39_06205	COG2814	Major facilitator Superfamily
KIH39_06210	COG2814	Major facilitator Superfamily
KIH39_06220	COG1621	beta-fructofuranosidase activity
KIH39_06275	COG3259	Nickel-dependent hydrogenase
KIH39_06280	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
KIH39_06285	COG3383	formate dehydrogenase (NAD+) activity
KIH39_06290	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KIH39_06295	COG0823	Involved in the tonB-independent uptake of proteins
KIH39_06295	COG1506	peptidase
KIH39_06295	COG4946	Tricorn protease homolog
KIH39_06340	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KIH39_06350	COG0366	Alpha amylase catalytic
KIH39_06405	COG2815	serine threonine protein kinase
KIH39_06405	COG0515	serine threonine protein kinase
KIH39_06415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KIH39_06450	COG0308	aminopeptidase N
KIH39_06480	COG3206	protein involved in exopolysaccharide biosynthesis
KIH39_06480	COG0489	protein tyrosine kinase activity
KIH39_06495	COG0515	serine threonine protein kinase
KIH39_06495	COG2815	serine threonine protein kinase
KIH39_06500	COG0643	Histidine kinase
KIH39_06500	COG0784	Response regulator, receiver
KIH39_06500	COG2198	Histidine kinase
KIH39_06505	COG0835	chemotaxis
KIH39_06515	COG2201	protein-glutamate methylesterase activity
KIH39_06540	COG0438	transferase activity, transferring glycosyl groups
KIH39_06595	COG2202	Pas domain
KIH39_06595	COG2205	protein histidine kinase activity
KIH39_06665	COG0705	Rhomboid family
KIH39_06665	COG0457	Tetratricopeptide repeat
KIH39_06700	COG0427	acetyl-CoA hydrolase
KIH39_06725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KIH39_06735	COG0489	protein tyrosine kinase activity
KIH39_06745	COG0515	serine threonine protein kinase
KIH39_06750	COG1696	Membrane protein involved in D-alanine export
KIH39_06770	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KIH39_06775	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KIH39_06795	COG0028	Belongs to the TPP enzyme family
KIH39_06815	COG0545	Peptidyl-prolyl cis-trans isomerase
KIH39_06820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KIH39_06855	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KIH39_06865	COG0515	serine threonine protein kinase
KIH39_06865	COG2815	serine threonine protein kinase
KIH39_06875	COG0758	DNA mediated transformation
KIH39_06875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KIH39_06895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KIH39_06910	COG3186	Phenylalanine-4-hydroxylase
KIH39_06925	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KIH39_06930	COG1966	Carbon starvation protein
KIH39_06935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KIH39_06965	COG2814	Major facilitator Superfamily
KIH39_06970	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KIH39_06985	COG1606	tRNA processing
KIH39_07000	COG1363	Peptidase, m42
KIH39_07005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KIH39_07015	COG4191	Histidine kinase
KIH39_07050	COG0436	Aminotransferase
KIH39_07055	COG1028	Short-chain dehydrogenase reductase Sdr
KIH39_07065	COG1968	undecaprenyl-diphosphatase activity
KIH39_07075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KIH39_07090	COG1131	(ABC) transporter
KIH39_07095	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KIH39_07165	COG2017	converts alpha-aldose to the beta-anomer
KIH39_07170	COG1131	(ABC) transporter
KIH39_07205	COG0402	S-adenosylhomocysteine deaminase activity
KIH39_07210	COG0604	alcohol dehydrogenase
KIH39_07215	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KIH39_07220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KIH39_07230	COG0179	Fumarylacetoacetate (FAA) hydrolase
KIH39_07240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KIH39_07260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KIH39_07265	COG0165	Argininosuccinate lyase
KIH39_07270	COG0019	diaminopimelate decarboxylase activity
KIH39_07285	COG2815	serine threonine protein kinase
KIH39_07285	COG0515	serine threonine protein kinase
KIH39_07295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KIH39_07300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KIH39_07305	COG1984	allophanate hydrolase subunit 2
KIH39_07345	COG0646	methionine synthase
KIH39_07345	COG1410	methionine synthase
KIH39_07360	COG0521	Mo-molybdopterin cofactor biosynthetic process
KIH39_07365	COG1454	alcohol dehydrogenase
KIH39_07380	COG1252	NADH dehydrogenase
KIH39_07390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KIH39_07405	COG4946	Tricorn protease homolog
KIH39_07405	COG1506	peptidase
KIH39_07405	COG0823	Involved in the tonB-independent uptake of proteins
KIH39_07410	COG2815	serine threonine protein kinase
KIH39_07410	COG0515	serine threonine protein kinase
KIH39_07435	COG0515	serine threonine protein kinase
KIH39_07435	COG2815	serine threonine protein kinase
KIH39_07450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KIH39_07495	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KIH39_07505	COG3119	arylsulfatase activity
KIH39_07525	COG3119	arylsulfatase activity
KIH39_07530	COG3119	arylsulfatase activity
KIH39_07620	COG0110	maltose O-acetyltransferase activity
KIH39_07640	COG0438	transferase activity, transferring glycosyl groups
KIH39_07645	COG0438	transferase activity, transferring glycosyl groups
KIH39_07665	COG0438	transferase activity, transferring glycosyl groups
KIH39_07690	COG1793	dna ligase
KIH39_07695	COG1201	RNA secondary structure unwinding
KIH39_07710	COG3335	DDE superfamily endonuclease
KIH39_07725	COG0438	transferase activity, transferring glycosyl groups
KIH39_07730	COG0438	transferase activity, transferring glycosyl groups
KIH39_07740	COG0297	glycogen (starch) synthase activity
KIH39_07770	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KIH39_07770	COG2755	lipolytic protein G-D-S-L family
KIH39_07795	COG0438	transferase activity, transferring glycosyl groups
KIH39_07805	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KIH39_07810	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KIH39_07810	COG2755	lipolytic protein G-D-S-L family
KIH39_07855	COG1216	Glycosyl transferase, family 2
KIH39_07865	COG5433	transposase activity
KIH39_07980	COG0515	serine threonine protein kinase
KIH39_08005	COG3436	PFAM IS66 Orf2 family protein
KIH39_08025	COG3344	reverse transcriptase
KIH39_08035	COG5433	transposase activity
KIH39_08060	COG5433	transposase activity
KIH39_08075	COG4191	Histidine kinase
KIH39_08075	COG0784	Response regulator, receiver
KIH39_08080	COG0784	Response regulator, receiver
KIH39_08085	COG4251	negative regulation of phosphorylation
KIH39_08090	COG0745	RESPONSE REGULATOR receiver
KIH39_08120	COG5002	protein histidine kinase activity
KIH39_08125	COG0784	Response regulator, receiver
KIH39_08135	COG0784	Response regulator, receiver
KIH39_08135	COG4191	Histidine kinase
KIH39_08160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KIH39_08185	COG5433	transposase activity
KIH39_08210	COG5433	transposase activity
KIH39_08230	COG0714	Associated with various cellular activities
KIH39_08260	COG2815	serine threonine protein kinase
KIH39_08260	COG0515	serine threonine protein kinase
KIH39_08320	COG0515	serine threonine protein kinase
KIH39_08320	COG2815	serine threonine protein kinase
KIH39_08330	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KIH39_08340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KIH39_08420	COG3436	PFAM IS66 Orf2 family protein
KIH39_08425	COG4372	Transposase
KIH39_08435	COG2205	protein histidine kinase activity
KIH39_08435	COG3437	response regulator, receiver
KIH39_08435	COG3850	Histidine kinase
KIH39_08435	COG4999	Histidine kinase
KIH39_08460	COG5433	transposase activity
KIH39_08475	COG1595	DNA-templated transcription, initiation
KIH39_08565	COG3436	PFAM IS66 Orf2 family protein
KIH39_08575	COG1309	transcriptional regulator
KIH39_08620	COG0515	serine threonine protein kinase
KIH39_08620	COG0457	Tetratricopeptide repeat
KIH39_08690	COG0793	Belongs to the peptidase S41A family
KIH39_08690	COG4946	Tricorn protease homolog
KIH39_08755	COG4585	Histidine kinase
KIH39_08760	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KIH39_08770	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
KIH39_08830	COG1595	DNA-templated transcription, initiation
KIH39_08870	COG2815	serine threonine protein kinase
KIH39_08870	COG0515	serine threonine protein kinase
KIH39_08930	COG0515	serine threonine protein kinase
KIH39_08930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KIH39_08950	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
KIH39_09005	COG1595	DNA-templated transcription, initiation
KIH39_09035	COG0300	oxidoreductase activity
KIH39_09065	COG2205	protein histidine kinase activity
KIH39_09100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KIH39_09190	COG0784	Response regulator, receiver
KIH39_09190	COG2198	Histidine kinase
KIH39_09190	COG5002	protein histidine kinase activity
KIH39_09200	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KIH39_09205	COG0330	HflC and HflK could
KIH39_09220	COG3228	Belongs to the MtfA family
KIH39_09225	COG2326	polyphosphate kinase activity
KIH39_09235	COG3588	fructose-bisphosphate aldolase
KIH39_09240	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
KIH39_09250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KIH39_09255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KIH39_09265	COG0356	it plays a direct role in the translocation of protons across the membrane
KIH39_09285	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KIH39_09295	COG0698	ribose 5-phosphate isomerase
KIH39_09320	COG0829	nickel cation binding
KIH39_09335	COG0804	urea catabolic process
KIH39_09340	COG0831	urea catabolic process
KIH39_09340	COG0832	Belongs to the urease beta subunit family
KIH39_09345	COG0831	urea catabolic process
KIH39_09460	COG4191	Histidine kinase
KIH39_09460	COG0784	Response regulator, receiver
KIH39_09465	COG2197	response regulator
KIH39_09470	COG4585	Histidine kinase
KIH39_09510	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
KIH39_09550	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KIH39_09555	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
KIH39_09590	COG4968	Prepilin-type N-terminal cleavage methylation domain
KIH39_09620	COG5433	transposase activity
KIH39_09630	COG0477	Major facilitator Superfamily
KIH39_09635	COG1671	Belongs to the UPF0178 family
KIH39_09665	COG3002	Belongs to the UPF0753 family
KIH39_09670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KIH39_09675	COG0583	DNA-binding transcription factor activity
KIH39_09680	COG0667	Aldo Keto reductase
KIH39_09720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KIH39_09725	COG0617	tRNA 3'-terminal CCA addition
KIH39_09815	COG1222	aaa ATPase
KIH39_09850	COG4964	Belongs to the GSP D family
KIH39_09935	COG0667	Aldo Keto reductase
KIH39_09940	COG0673	inositol 2-dehydrogenase activity
KIH39_09970	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KIH39_10055	COG0247	lactate metabolic process
KIH39_10055	COG0277	FAD linked oxidase domain protein
KIH39_10060	COG0698	ribose 5-phosphate isomerase
KIH39_10130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_10135	COG3590	peptidase
KIH39_10140	COG2755	lipolytic protein G-D-S-L family
KIH39_10140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KIH39_10160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KIH39_10165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KIH39_10170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KIH39_10185	COG0531	amino acid
KIH39_10190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KIH39_10260	COG1733	regulation of RNA biosynthetic process
KIH39_10310	COG4106	trans-aconitate 2-methyltransferase activity
KIH39_10330	COG0488	(ABC) transporter
KIH39_10445	COG0114	fumarate hydratase activity
KIH39_10480	COG0297	glycogen (starch) synthase activity
KIH39_10495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KIH39_10505	COG1193	negative regulation of DNA recombination
KIH39_10515	COG0698	ribose 5-phosphate isomerase
KIH39_10520	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KIH39_10565	COG1663	tetraacyldisaccharide 4'-kinase activity
KIH39_10590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KIH39_10595	COG0525	valine-tRNA ligase activity
KIH39_10600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KIH39_10620	COG2183	response to ionizing radiation
KIH39_10625	COG1301	dicarboxylic acid transport
KIH39_10645	COG0515	serine threonine protein kinase
KIH39_10645	COG2815	serine threonine protein kinase
KIH39_10650	COG1191	sigma factor activity
KIH39_10660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KIH39_10670	COG0515	serine threonine protein kinase
KIH39_10670	COG2815	serine threonine protein kinase
KIH39_10680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KIH39_10755	COG0318	PFAM AMP-dependent synthetase and ligase
KIH39_10755	COG0204	Acyl-transferase
KIH39_10780	COG1136	(ABC) transporter
KIH39_10790	COG0577	efflux transmembrane transporter activity
KIH39_10795	COG0477	Major facilitator Superfamily
KIH39_10845	COG1459	type II secretion system
KIH39_10850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KIH39_10870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KIH39_10885	COG1214	PFAM Peptidase M22, glycoprotease
KIH39_10890	COG0328	RNA-DNA hybrid ribonuclease activity
KIH39_10945	COG2095	MarC family integral membrane protein
KIH39_10950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KIH39_10960	COG1132	(ABC) transporter
KIH39_10970	COG4974	Belongs to the 'phage' integrase family
KIH39_10980	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KIH39_10990	COG0515	serine threonine protein kinase
KIH39_10990	COG2815	serine threonine protein kinase
KIH39_11035	COG4191	Histidine kinase
KIH39_11040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KIH39_11045	COG0765	amino acid transport
KIH39_11050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KIH39_11060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KIH39_11080	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KIH39_11085	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
KIH39_11090	COG1126	abc transporter atp-binding protein
KIH39_11100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KIH39_11105	COG0443	Heat shock 70 kDa protein
KIH39_11110	COG0077	Prephenate dehydratase
KIH39_11110	COG1605	Chorismate mutase
KIH39_11115	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KIH39_11120	COG0149	triose-phosphate isomerase activity
KIH39_11125	COG2321	neutral zinc metallopeptidase
KIH39_11130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KIH39_11150	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KIH39_11155	COG0456	acetyltransferase
KIH39_11180	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KIH39_11260	COG0300	oxidoreductase activity
KIH39_11280	COG1063	alcohol dehydrogenase
KIH39_11290	COG0826	peptidase U32
KIH39_11295	COG0268	Binds directly to 16S ribosomal RNA
KIH39_11300	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KIH39_11305	COG0052	Belongs to the universal ribosomal protein uS2 family
KIH39_11395	COG2204	response regulator
KIH39_11410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KIH39_11415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KIH39_11420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KIH39_11425	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KIH39_11445	COG0481	GTPase activity
KIH39_11455	COG3852	Histidine kinase
KIH39_11470	COG0745	RESPONSE REGULATOR receiver
KIH39_11505	COG4948	Mandelate Racemase Muconate Lactonizing
KIH39_11525	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KIH39_11535	COG1547	Domain of unknown function (DUF309)
KIH39_11540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KIH39_11545	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KIH39_11555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KIH39_11560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KIH39_11565	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KIH39_11575	COG0584	glycerophosphoryl diester phosphodiesterase
KIH39_11580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KIH39_11585	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KIH39_11595	COG1515	deoxyribonuclease V activity
KIH39_11615	COG0438	transferase activity, transferring glycosyl groups
KIH39_11645	COG0516	GMP reductase activity
KIH39_11645	COG0517	IMP dehydrogenase activity
KIH39_11650	COG0673	inositol 2-dehydrogenase activity
KIH39_11675	COG0642	Histidine kinase
KIH39_11735	COG2815	serine threonine protein kinase
KIH39_11735	COG0515	serine threonine protein kinase
KIH39_11745	COG1505	serine-type exopeptidase activity
KIH39_11765	COG0673	inositol 2-dehydrogenase activity
KIH39_11770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KIH39_11795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KIH39_11820	COG0527	aspartate kinase activity
KIH39_11870	COG5002	protein histidine kinase activity
KIH39_11875	COG0784	Response regulator, receiver
KIH39_11880	COG4251	negative regulation of phosphorylation
KIH39_11885	COG2204	response regulator
KIH39_11890	COG3459	Glycosyltransferase 36 associated
KIH39_11905	COG2267	carboxylic ester hydrolase activity
KIH39_11915	COG5487	UPF0391 membrane protein
KIH39_11930	COG0628	permease
KIH39_11950	COG2226	methyltransferase
KIH39_12025	COG0505	Belongs to the CarA family
KIH39_12035	COG0515	serine threonine protein kinase
KIH39_12035	COG2815	serine threonine protein kinase
KIH39_12045	COG0131	Imidazoleglycerol-phosphate dehydratase
KIH39_12050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KIH39_12055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KIH39_12060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KIH39_12070	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KIH39_12085	COG0154	amidase activity
KIH39_12160	COG2819	hydrolase of the alpha beta superfamily
KIH39_12180	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KIH39_12190	COG2313	pseudouridylate synthase activity
KIH39_12200	COG1692	metallophosphoesterase
KIH39_12205	COG1418	mRNA catabolic process
KIH39_12220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KIH39_12255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KIH39_12260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KIH39_12270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KIH39_12295	COG1082	Xylose isomerase domain protein TIM barrel
KIH39_12305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KIH39_12305	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KIH39_12330	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KIH39_12335	COG0233	cytoplasmic translational termination
KIH39_12345	COG1595	DNA-templated transcription, initiation
KIH39_12355	COG1082	Xylose isomerase domain protein TIM barrel
KIH39_12375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KIH39_12380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KIH39_12385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KIH39_12395	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KIH39_12420	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KIH39_12425	COG2204	response regulator
KIH39_12440	COG1247	-acetyltransferase
KIH39_12445	COG0424	maF-like protein
KIH39_12450	COG0859	PFAM glycosyl transferase family 9
KIH39_12465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KIH39_12490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KIH39_12500	COG2091	lysine biosynthetic process via aminoadipic acid
KIH39_12535	COG0552	protein localization to endoplasmic reticulum
KIH39_12540	COG0010	Belongs to the arginase family
KIH39_12580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KIH39_12595	COG4636	protein conserved in cyanobacteria
KIH39_12605	COG1121	(ABC) transporter
KIH39_12610	COG0803	Belongs to the bacterial solute-binding protein 9 family
KIH39_12625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_12630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_12635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_12675	COG0714	Associated with various cellular activities
KIH39_12725	COG2721	sulfolactate sulfo-lyase activity
KIH39_12760	COG0805	protein transport
KIH39_12810	COG1131	(ABC) transporter
KIH39_12835	COG0156	8-amino-7-oxononanoate synthase activity
KIH39_12840	COG2706	6-phosphogluconolactonase activity
KIH39_12860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KIH39_12865	COG2890	protein-(glutamine-N5) methyltransferase activity
KIH39_12890	COG0673	inositol 2-dehydrogenase activity
KIH39_12895	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KIH39_12930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KIH39_12935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KIH39_12950	COG1741	Belongs to the pirin family
KIH39_12960	COG0022	dehydrogenase e1 component
KIH39_12965	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KIH39_12975	COG2308	Evidence 4 Homologs of previously reported genes of
KIH39_12995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KIH39_13035	COG0028	Belongs to the TPP enzyme family
KIH39_13040	COG0475	glutathione-regulated potassium exporter activity
KIH39_13065	COG1229	Formylmethanofuran dehydrogenase subunit A
KIH39_13080	COG3963	phosphatidate phosphatase activity
KIH39_13105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KIH39_13120	COG0189	ligase activity
KIH39_13125	COG3422	double-strand break repair
KIH39_13160	COG0196	riboflavin kinase activity
KIH39_13165	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KIH39_13180	COG0534	Mate efflux family protein
KIH39_13250	COG1104	cysteine desulfurase activity
KIH39_13260	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KIH39_13270	COG0463	Glycosyl transferase, family 2
KIH39_13285	COG0745	RESPONSE REGULATOR receiver
KIH39_13290	COG2205	protein histidine kinase activity
KIH39_13290	COG0784	Response regulator, receiver
KIH39_13290	COG5002	protein histidine kinase activity
KIH39_13300	COG0784	Response regulator, receiver
KIH39_13300	COG4191	Histidine kinase
KIH39_13305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KIH39_13310	COG0612	Peptidase, M16
KIH39_13320	COG0049	tRNA binding
KIH39_13325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KIH39_13335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KIH39_13350	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KIH39_13350	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KIH39_13360	COG1063	alcohol dehydrogenase
KIH39_13390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KIH39_13395	COG1012	belongs to the aldehyde dehydrogenase family
KIH39_13410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KIH39_13415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KIH39_13420	COG0151	Belongs to the GarS family
KIH39_13445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KIH39_13450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KIH39_13455	COG0166	Belongs to the GPI family
KIH39_13460	COG5001	Diguanylate cyclase
KIH39_13475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KIH39_13485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KIH39_13495	COG1530	ribonuclease E activity
KIH39_13495	COG1530	ribonuclease E activity
KIH39_13510	COG0142	geranyltranstransferase activity
KIH39_13545	COG3869	Catalyzes the specific phosphorylation of arginine residues in
KIH39_13565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KIH39_13570	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KIH39_13610	COG4946	Tricorn protease homolog
KIH39_13610	COG0793	Belongs to the peptidase S41A family
KIH39_13615	COG0564	pseudouridine synthase activity
KIH39_13625	COG1774	PSP1 C-terminal conserved region
KIH39_13630	COG1028	Short-chain dehydrogenase reductase Sdr
KIH39_13690	COG3119	arylsulfatase activity
KIH39_13695	COG0557	exoribonuclease II activity
KIH39_13710	COG5285	phytanoyl-CoA dioxygenase
KIH39_13735	COG0784	Response regulator, receiver
KIH39_13735	COG2198	Histidine kinase
KIH39_13735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KIH39_13735	COG2205	protein histidine kinase activity
KIH39_13745	COG0667	Aldo Keto reductase
KIH39_13770	COG1132	(ABC) transporter
KIH39_13780	COG0673	inositol 2-dehydrogenase activity
KIH39_13785	COG5002	protein histidine kinase activity
KIH39_13790	COG4251	negative regulation of phosphorylation
KIH39_13795	COG4251	negative regulation of phosphorylation
KIH39_13800	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KIH39_13810	COG5002	protein histidine kinase activity
KIH39_13835	COG0326	Molecular chaperone. Has ATPase activity
KIH39_13850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KIH39_13860	COG1482	cell wall glycoprotein biosynthetic process
KIH39_13870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KIH39_13875	COG1560	Kdo2-lipid A biosynthetic process
KIH39_13880	COG0673	inositol 2-dehydrogenase activity
KIH39_13885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KIH39_13890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KIH39_13905	COG1595	DNA-templated transcription, initiation
KIH39_13920	COG0709	Synthesizes selenophosphate from selenide and ATP
KIH39_13925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KIH39_13935	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KIH39_13950	COG0405	Gamma-glutamyltransferase
KIH39_13955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KIH39_13970	COG5564	TIM-barrel signal transduction protein
KIH39_14020	COG1064	alcohol dehydrogenase
KIH39_14065	COG3012	SEC-C Motif Domain Protein
KIH39_14065	COG1405	negative regulation of cell septum assembly
KIH39_14080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KIH39_14085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KIH39_14150	COG1518	maintenance of DNA repeat elements
KIH39_14150	COG1468	defense response to virus
KIH39_14155	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KIH39_14195	COG0477	Major facilitator Superfamily
KIH39_14200	COG0438	transferase activity, transferring glycosyl groups
KIH39_14225	COG2226	methyltransferase
KIH39_14235	COG1053	succinate dehydrogenase
KIH39_14265	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
KIH39_14270	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KIH39_14280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KIH39_14285	COG0793	Belongs to the peptidase S41A family
KIH39_14315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KIH39_14320	COG0250	Participates in transcription elongation, termination and antitermination
KIH39_14325	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KIH39_14335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KIH39_14360	COG2205	protein histidine kinase activity
KIH39_14370	COG0653	protein targeting
KIH39_14380	COG0501	Belongs to the peptidase M48B family
KIH39_14405	COG2165	general secretion pathway protein
KIH39_14415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KIH39_14415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KIH39_14480	COG4591	ABC-type transport system involved in lipoprotein release permease component
KIH39_14485	COG1136	(ABC) transporter
KIH39_14500	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KIH39_14500	COG4651	solute:proton antiporter activity
KIH39_14525	COG0673	inositol 2-dehydrogenase activity
KIH39_14540	COG0714	Associated with various cellular activities
KIH39_14570	COG0657	acetylesterase activity
KIH39_14580	COG1899	peptidyl-lysine modification to peptidyl-hypusine
KIH39_14610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KIH39_14615	COG0509	glycine decarboxylation via glycine cleavage system
KIH39_14630	COG5433	transposase activity
KIH39_14675	COG4232	protein-disulfide reductase activity
KIH39_14695	COG0714	Associated with various cellular activities
KIH39_14705	COG0095	Lipoate-protein ligase
KIH39_14740	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KIH39_14745	COG0372	Belongs to the citrate synthase family
KIH39_14815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KIH39_14825	COG2226	methyltransferase
KIH39_14855	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KIH39_14860	COG0509	glycine decarboxylation via glycine cleavage system
KIH39_14865	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KIH39_14875	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KIH39_14915	COG0714	Associated with various cellular activities
KIH39_14955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KIH39_15000	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KIH39_15025	COG0783	Belongs to the Dps family
KIH39_15060	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
KIH39_15085	COG1160	GTP binding
KIH39_15090	COG0717	Belongs to the dCTP deaminase family
KIH39_15130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KIH39_15135	COG0714	Associated with various cellular activities
KIH39_15155	COG2030	dehydratase
KIH39_15160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KIH39_15165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KIH39_15170	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KIH39_15210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KIH39_15260	COG0412	Dienelactone hydrolase
KIH39_15425	COG0515	serine threonine protein kinase
KIH39_15425	COG2815	serine threonine protein kinase
KIH39_15520	COG0457	Tetratricopeptide repeat
KIH39_15520	COG0463	Glycosyl transferase, family 2
KIH39_15555	COG3344	reverse transcriptase
KIH39_15665	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KIH39_15710	COG0515	serine threonine protein kinase
KIH39_15710	COG2815	serine threonine protein kinase
KIH39_15715	COG0750	zinc metalloprotease
KIH39_15750	COG0515	serine threonine protein kinase
KIH39_15810	COG0210	DNA helicase
KIH39_15815	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KIH39_15820	COG4372	Transposase
KIH39_15915	COG3209	COG3209 Rhs family protein
KIH39_16015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KIH39_16020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KIH39_16025	COG0237	dephospho-CoA kinase activity
KIH39_16035	COG0714	Associated with various cellular activities
KIH39_16080	COG2855	membrane
KIH39_16105	COG0523	cobalamin synthesis protein
KIH39_16145	COG2204	response regulator
KIH39_16175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KIH39_16180	COG1136	(ABC) transporter
KIH39_16195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KIH39_16210	COG1233	COG1233 Phytoene dehydrogenase and related
KIH39_16220	COG1595	DNA-templated transcription, initiation
KIH39_16235	COG1215	transferase activity, transferring glycosyl groups
KIH39_16240	COG1012	belongs to the aldehyde dehydrogenase family
KIH39_16245	COG1819	glycosyl
KIH39_16275	COG0754	glutathionylspermidine amidase activity
KIH39_16290	COG1490	D-aminoacyl-tRNA deacylase activity
KIH39_16295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_16300	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KIH39_16345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KIH39_16350	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KIH39_16355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_16360	COG0067	glutamate synthase
KIH39_16360	COG0069	glutamate synthase activity
KIH39_16360	COG0070	glutamate synthase
KIH39_16435	COG0154	amidase activity
KIH39_16450	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KIH39_16475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KIH39_16495	COG0488	(ABC) transporter
KIH39_16525	COG2815	serine threonine protein kinase
KIH39_16525	COG0515	serine threonine protein kinase
KIH39_16545	COG0300	oxidoreductase activity
KIH39_16550	COG0275	rRNA processing
KIH39_16570	COG3507	Belongs to the glycosyl hydrolase 43 family
KIH39_16570	COG2382	esterase
KIH39_16570	COG3693	PFAM glycoside hydrolase, family 10
KIH39_16590	COG1595	DNA-templated transcription, initiation
KIH39_16615	COG2706	6-phosphogluconolactonase activity
KIH39_16670	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KIH39_16690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_16695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KIH39_16725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KIH39_16735	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KIH39_16755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KIH39_16760	COG3876	Protein conserved in bacteria
KIH39_16785	COG0259	pyridoxamine-phosphate oxidase activity
KIH39_16795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KIH39_16800	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KIH39_16815	COG0045	succinate-CoA ligase (ADP-forming) activity
KIH39_16825	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KIH39_16845	COG0571	ribonuclease III activity
KIH39_16855	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KIH39_16865	COG3481	metal-dependent phosphohydrolase, HD sub domain
KIH39_16870	COG0557	exoribonuclease II activity
KIH39_16880	COG2211	Major facilitator Superfamily
KIH39_16890	COG0825	malonyl-CoA metabolic process
KIH39_16920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KIH39_16980	COG0275	rRNA processing
KIH39_17005	COG1213	nucleotidyl transferase
KIH39_17025	COG0288	reversible hydration of carbon dioxide
KIH39_17030	COG2115	Belongs to the xylose isomerase family
KIH39_17040	COG0552	protein localization to endoplasmic reticulum
KIH39_17070	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
KIH39_17080	COG0515	serine threonine protein kinase
KIH39_17100	COG3437	response regulator, receiver
KIH39_17110	COG0495	leucyl-tRNA aminoacylation
KIH39_17135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KIH39_17140	COG0254	rRNA binding
KIH39_17160	COG0727	PFAM Uncharacterised protein family (UPF0153)
KIH39_17175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KIH39_17185	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KIH39_17195	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KIH39_17200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KIH39_17205	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KIH39_17215	COG0539	negative regulation of cytoplasmic translation
KIH39_17220	COG0515	serine threonine protein kinase
KIH39_17220	COG2815	serine threonine protein kinase
KIH39_17240	COG0113	porphobilinogen synthase activity
KIH39_17265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KIH39_17270	COG0012	GTP binding
KIH39_17280	COG1196	nuclear chromosome segregation
KIH39_17295	COG1054	Belongs to the UPF0176 family
KIH39_17330	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KIH39_17340	COG2205	protein histidine kinase activity
KIH39_17355	COG0443	Heat shock 70 kDa protein
KIH39_17370	COG0076	glutamate decarboxylase activity
KIH39_17385	COG2096	Adenosyltransferase
KIH39_17425	COG2239	Acts as a magnesium transporter
KIH39_17445	COG2304	oxidoreductase activity
KIH39_17460	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KIH39_17475	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
KIH39_17510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KIH39_17520	COG1561	YicC-like family, N-terminal region
KIH39_17525	COG0194	GDP metabolic process
KIH39_17530	COG1758	RNA polymerase activity
KIH39_17550	COG2815	serine threonine protein kinase
KIH39_17550	COG0515	serine threonine protein kinase
KIH39_17555	COG0564	pseudouridine synthase activity
KIH39_17565	COG0432	Pfam Uncharacterised protein family UPF0047
KIH39_17580	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KIH39_17595	COG0616	signal peptide processing
KIH39_17600	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KIH39_17605	COG0210	DNA helicase
KIH39_17650	COG0515	serine threonine protein kinase
KIH39_17660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KIH39_17665	COG0101	tRNA pseudouridine synthase activity
KIH39_17670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KIH39_17695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KIH39_17700	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KIH39_17705	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KIH39_17740	COG0488	(ABC) transporter
KIH39_17770	COG0793	Belongs to the peptidase S41A family
KIH39_17770	COG4946	Tricorn protease homolog
KIH39_17820	COG2755	lipolytic protein G-D-S-L family
KIH39_17820	COG0657	acetylesterase activity
KIH39_17870	COG3119	arylsulfatase activity
KIH39_17960	COG3795	YCII-related domain
KIH39_17970	COG4941	Belongs to the sigma-70 factor family
KIH39_17980	COG1846	Transcriptional regulator
KIH39_17995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KIH39_18000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KIH39_18005	COG0640	Transcriptional regulator
KIH39_18010	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
KIH39_18050	COG3548	integral membrane protein
KIH39_18065	COG3119	arylsulfatase activity
KIH39_18075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KIH39_18100	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KIH39_18125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KIH39_18220	COG1459	type II secretion system
KIH39_18225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KIH39_18235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KIH39_18250	COG4974	Belongs to the 'phage' integrase family
KIH39_18290	COG1192	Involved in chromosome partitioning
KIH39_18325	COG4372	Transposase
KIH39_18470	COG0443	Heat shock 70 kDa protein
KIH39_18475	COG1028	Short-chain dehydrogenase reductase Sdr
KIH39_18510	COG3685	Protein conserved in bacteria
KIH39_18515	COG1295	ribonuclease BN
KIH39_18545	COG0024	Methionine aminopeptidase
KIH39_18550	COG0563	adenylate kinase activity
KIH39_18555	COG0201	protein transport
KIH39_18560	COG0200	Binds to the 23S rRNA
KIH39_18565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KIH39_18570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KIH39_18580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KIH39_18585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KIH39_18590	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KIH39_18595	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KIH39_18600	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KIH39_18605	COG0255	Belongs to the universal ribosomal protein uL29 family
KIH39_18610	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KIH39_18615	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KIH39_18620	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KIH39_18625	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KIH39_18630	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KIH39_18635	COG0089	rRNA binding
KIH39_18640	COG0088	Forms part of the polypeptide exit tunnel
KIH39_18645	COG0051	transcription antitermination factor activity, RNA binding
KIH39_18680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KIH39_18685	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KIH39_18730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KIH39_18740	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KIH39_18760	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KIH39_18775	COG0745	RESPONSE REGULATOR receiver
KIH39_18785	COG0840	transmembrane signaling receptor activity
KIH39_18790	COG2198	Histidine kinase
KIH39_18790	COG0784	Response regulator, receiver
KIH39_18790	COG0643	Histidine kinase
KIH39_18850	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KIH39_18875	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KIH39_18875	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KIH39_18880	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
KIH39_18890	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KIH39_18985	COG0649	NAD binding
KIH39_18990	COG1119	ATPase activity
KIH39_19000	COG0439	Biotin carboxylase
KIH39_19005	COG0511	ligase activity, forming carbon-carbon bonds
KIH39_19010	COG0006	proline dipeptidase activity
KIH39_19025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KIH39_19070	COG3842	ATPase activity
KIH39_19090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KIH39_19095	COG1331	Highly conserved protein containing a thioredoxin domain
KIH39_19115	COG1305	Transglutaminase-like
KIH39_19130	COG1054	Belongs to the UPF0176 family
KIH39_19150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KIH39_19245	COG1858	cytochrome C peroxidase
KIH39_19250	COG3132	Protein of unknown function, DUF480
KIH39_19255	COG1187	pseudouridine synthase activity
KIH39_19260	COG0543	2 iron, 2 sulfur cluster binding
KIH39_19285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KIH39_19295	COG0864	Transcriptional regulator
KIH39_19305	COG4968	Prepilin-type N-terminal cleavage methylation domain
KIH39_19325	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KIH39_19355	COG0673	inositol 2-dehydrogenase activity
KIH39_19360	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KIH39_19450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KIH39_19460	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KIH39_19495	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KIH39_19500	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
KIH39_19510	COG0469	pyruvate kinase activity
KIH39_19515	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KIH39_19535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KIH39_19550	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KIH39_19630	COG0386	Belongs to the glutathione peroxidase family
KIH39_19635	COG2132	Multicopper oxidase
KIH39_19640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KIH39_19660	COG0105	UTP biosynthetic process
KIH39_19730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KIH39_19785	COG2815	serine threonine protein kinase
KIH39_19785	COG0515	serine threonine protein kinase
KIH39_19805	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KIH39_19835	COG0667	Aldo Keto reductase
KIH39_19845	COG4302	ethanolamine ammonia-lyase activity
KIH39_19855	COG4303	Ethanolamine ammonia lyase large subunit
KIH39_19880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KIH39_19905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KIH39_19910	COG0450	alkyl hydroperoxide reductase
KIH39_19920	COG1131	(ABC) transporter
KIH39_19955	COG1297	OPT oligopeptide transporter protein
KIH39_19960	COG0482	sulfurtransferase activity
KIH39_19970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KIH39_19990	COG0673	inositol 2-dehydrogenase activity
KIH39_19995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KIH39_20005	COG0181	hydroxymethylbilane synthase activity
KIH39_20015	COG0242	peptide deformylase activity
KIH39_20025	COG0622	Phosphoesterase
KIH39_20030	COG1408	metallophosphoesterase
KIH39_20085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KIH39_20090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KIH39_20120	COG0673	inositol 2-dehydrogenase activity
KIH39_20125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KIH39_20130	COG0463	Glycosyl transferase, family 2
KIH39_20145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KIH39_20150	COG0438	transferase activity, transferring glycosyl groups
KIH39_20170	COG0438	transferase activity, transferring glycosyl groups
KIH39_20190	COG1216	Glycosyl transferase, family 2
KIH39_20215	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KIH39_20240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KIH39_20245	COG0066	3-isopropylmalate dehydratase activity
KIH39_20260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KIH39_20260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KIH39_20315	COG1796	DNA polymerase
KIH39_20315	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KIH39_20325	COG1475	DNA binding
KIH39_20360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KIH39_20415	COG1162	GTPase activity
KIH39_20425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KIH39_20475	COG0445	tRNA wobble uridine modification
KIH39_20510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KIH39_20515	COG0592	DNA-directed DNA polymerase activity
KIH39_20565	COG1136	(ABC) transporter
KIH39_20565	COG0577	efflux transmembrane transporter activity
KIH39_20595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KIH39_20620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KIH39_20695	COG3119	arylsulfatase activity
KIH39_20730	COG0175	sulfate reduction
KIH39_20735	COG1959	2 iron, 2 sulfur cluster binding
KIH39_20740	COG2046	Belongs to the sulfate adenylyltransferase family
KIH39_20830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KIH39_20835	COG1028	Short-chain dehydrogenase reductase Sdr
KIH39_20840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KIH39_20845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KIH39_20850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KIH39_20855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KIH39_20875	COG3591	Belongs to the peptidase S1B family
KIH39_20880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KIH39_20890	COG1959	2 iron, 2 sulfur cluster binding
KIH39_20925	COG0539	negative regulation of cytoplasmic translation
KIH39_20925	COG2183	response to ionizing radiation
KIH39_20930	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
KIH39_20965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KIH39_20970	COG0493	'glutamate synthase
KIH39_20980	COG2815	serine threonine protein kinase
KIH39_20980	COG0515	serine threonine protein kinase
KIH39_20990	COG0515	serine threonine protein kinase
KIH39_20990	COG2815	serine threonine protein kinase
KIH39_21015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KIH39_21020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KIH39_21030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KIH39_21040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KIH39_21055	COG2165	general secretion pathway protein
KIH39_21060	COG1366	Belongs to the anti-sigma-factor antagonist family
KIH39_21065	COG1366	Belongs to the anti-sigma-factor antagonist family
KIH39_21070	COG2172	sigma factor antagonist activity
KIH39_21080	COG2205	protein histidine kinase activity
KIH39_21085	COG2205	protein histidine kinase activity
KIH39_21085	COG0784	Response regulator, receiver
KIH39_21105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KIH39_21135	COG2755	lipolytic protein G-D-S-L family
KIH39_21135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KIH39_21140	COG1506	peptidase
KIH39_21140	COG0823	Involved in the tonB-independent uptake of proteins
KIH39_21160	COG0842	Transport permease protein
KIH39_21165	COG0842	Transport permease protein
KIH39_21170	COG1131	(ABC) transporter
KIH39_21180	COG1309	transcriptional regulator
KIH39_21190	COG0326	Molecular chaperone. Has ATPase activity
KIH39_21335	COG2815	serine threonine protein kinase
KIH39_21335	COG0515	serine threonine protein kinase
KIH39_21350	COG1446	asparaginase
KIH39_21355	COG0824	Thioesterase
KIH39_21385	COG0457	Tetratricopeptide repeat
KIH39_21385	COG0515	serine threonine protein kinase
KIH39_21390	COG0667	Aldo Keto reductase
KIH39_21400	COG0515	serine threonine protein kinase
KIH39_21400	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KIH39_21425	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KIH39_21500	COG0515	serine threonine protein kinase
KIH39_21500	COG2815	serine threonine protein kinase
KIH39_21515	COG1228	amidohydrolase
KIH39_21545	COG0784	Response regulator, receiver
KIH39_21550	COG4251	negative regulation of phosphorylation
KIH39_21555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KIH39_21575	COG0515	serine threonine protein kinase
KIH39_21575	COG2815	serine threonine protein kinase
KIH39_21610	COG1192	Involved in chromosome partitioning
KIH39_21615	COG1192	Involved in chromosome partitioning
KIH39_21625	COG0473	3-isopropylmalate dehydrogenase activity
KIH39_21635	COG0138	bifunctional purine biosynthesis protein purh
KIH39_21655	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KIH39_21655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KIH39_21670	COG0346	lactoylglutathione lyase activity
KIH39_21675	COG5433	transposase activity
KIH39_21680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KIH39_21710	COG3386	PFAM SMP-30 Gluconolaconase
KIH39_21715	COG0215	cysteine-tRNA ligase activity
KIH39_21730	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KIH39_21735	COG0632	four-way junction helicase activity
KIH39_21745	COG2255	four-way junction helicase activity
KIH39_21755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KIH39_21770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KIH39_21785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KIH39_21795	COG3850	Histidine kinase
KIH39_21795	COG5002	protein histidine kinase activity
KIH39_21870	COG0515	serine threonine protein kinase
KIH39_21870	COG2815	serine threonine protein kinase
KIH39_21900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KIH39_21905	COG1550	Protein conserved in bacteria
KIH39_21910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KIH39_21970	COG0287	Prephenate dehydrogenase
KIH39_21975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KIH39_22010	COG2207	Transcriptional regulator
KIH39_22015	COG3059	membrane
KIH39_22070	COG1136	(ABC) transporter
KIH39_22150	COG1272	protein, Hemolysin III
KIH39_22155	COG2815	serine threonine protein kinase
KIH39_22155	COG0515	serine threonine protein kinase
KIH39_22160	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
KIH39_22165	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KIH39_22170	COG0633	Ferredoxin
KIH39_22210	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KIH39_22215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KIH39_22220	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KIH39_22230	COG0649	NAD binding
KIH39_22240	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KIH39_22260	COG1034	ATP synthesis coupled electron transport
KIH39_22265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KIH39_22270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KIH39_22275	COG0839	Belongs to the complex I subunit 6 family
KIH39_22280	COG0713	ATP synthesis coupled electron transport
KIH39_22295	COG1007	ATP synthesis coupled electron transport
KIH39_22315	COG2135	peptidase activity
KIH39_22320	COG3278	Belongs to the heme-copper respiratory oxidase family
KIH39_22335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KIH39_22345	COG1222	aaa ATPase
KIH39_22350	COG0124	histidyl-tRNA synthetase
KIH39_22355	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
KIH39_22365	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KIH39_22370	COG0714	Associated with various cellular activities
KIH39_22375	COG4537	Required for transformation and DNA binding
KIH39_22420	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KIH39_22445	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KIH39_22445	COG2199	diguanylate cyclase activity
KIH39_22450	COG0730	response to heat
KIH39_22460	COG0217	transcriptional regulatory protein
KIH39_22485	COG1473	amidohydrolase
KIH39_22490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KIH39_22515	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KIH39_22565	COG3119	arylsulfatase activity
KIH39_22610	COG0714	Associated with various cellular activities
KIH39_22620	COG3552	Protein containing von Willebrand factor type A (VWA) domain
KIH39_22730	COG1192	Involved in chromosome partitioning
KIH39_22755	COG4227	nucleotidyltransferase activity
KIH39_22795	COG0515	serine threonine protein kinase
KIH39_22795	COG2815	serine threonine protein kinase
KIH39_23015	COG0783	Belongs to the Dps family
KIH39_23020	COG1028	Short-chain dehydrogenase reductase Sdr
KIH39_23025	COG1028	Short-chain dehydrogenase reductase Sdr
KIH39_23045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KIH39_23055	COG2815	serine threonine protein kinase
KIH39_23055	COG0515	serine threonine protein kinase
KIH39_23065	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KIH39_23105	COG0596	Alpha beta hydrolase
KIH39_23115	COG1764	response to oxidative stress
KIH39_23130	COG2815	serine threonine protein kinase
KIH39_23130	COG0515	serine threonine protein kinase
KIH39_23155	COG0457	Tetratricopeptide repeat
KIH39_23155	COG0515	serine threonine protein kinase
KIH39_23160	COG5433	transposase activity
KIH39_23185	COG0604	alcohol dehydrogenase
KIH39_23185	COG4221	oxidoreductase activity
KIH39_23185	COG3321	synthase
KIH39_23185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KIH39_23200	COG3693	PFAM glycoside hydrolase, family 10
KIH39_23200	COG3507	Belongs to the glycosyl hydrolase 43 family
KIH39_23200	COG2382	esterase
KIH39_23215	COG1595	DNA-templated transcription, initiation
KIH39_23290	COG4152	abc transporter atp-binding protein
KIH39_23325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_23335	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KIH39_23360	COG3383	formate dehydrogenase (NAD+) activity
KIH39_23365	COG0243	molybdopterin cofactor binding
KIH39_23370	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KIH39_23380	COG1164	Oligoendopeptidase f
KIH39_23390	COG1902	pentaerythritol trinitrate reductase activity
KIH39_23405	COG2172	sigma factor antagonist activity
KIH39_23415	COG0793	Belongs to the peptidase S41A family
KIH39_23440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KIH39_23485	COG1691	(AIR) carboxylase
KIH39_23490	COG1028	Short-chain dehydrogenase reductase Sdr
KIH39_23495	COG0367	asparagine synthase
KIH39_23555	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KIH39_23560	COG3012	SEC-C Motif Domain Protein
KIH39_23565	COG2814	Major facilitator Superfamily
KIH39_23585	COG0515	serine threonine protein kinase
KIH39_23585	COG2815	serine threonine protein kinase
KIH39_23590	COG1764	response to oxidative stress
KIH39_23600	COG1064	alcohol dehydrogenase
KIH39_23605	COG3384	dioxygenase
KIH39_23635	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KIH39_23700	COG0492	ferredoxin-NADP+ reductase activity
KIH39_23705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KIH39_23710	COG1620	l-lactate permease
KIH39_23715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_23720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_23745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KIH39_23750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KIH39_23755	COG0154	amidase activity
KIH39_23785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KIH39_23785	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KIH39_23795	COG2197	response regulator
KIH39_23810	COG1970	mechanosensitive ion channel activity
KIH39_23905	COG3119	arylsulfatase activity
KIH39_23930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KIH39_23935	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KIH39_23945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KIH39_23950	COG4974	Belongs to the 'phage' integrase family
KIH39_23965	COG0346	lactoylglutathione lyase activity
KIH39_23980	COG0784	Response regulator, receiver
KIH39_23985	COG4251	negative regulation of phosphorylation
KIH39_24010	COG0438	transferase activity, transferring glycosyl groups
KIH39_24015	COG0367	asparagine synthase
KIH39_24045	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KIH39_24060	COG1216	Glycosyl transferase, family 2
KIH39_24070	COG2204	response regulator
KIH39_24110	COG3842	ATPase activity
KIH39_24115	COG0195	Participates in both transcription termination and antitermination
KIH39_24140	COG2201	protein-glutamate methylesterase activity
KIH39_24160	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KIH39_24165	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KIH39_24170	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
KIH39_24175	COG2205	protein histidine kinase activity
KIH39_24180	COG0745	RESPONSE REGULATOR receiver
KIH39_24195	COG0823	Involved in the tonB-independent uptake of proteins
KIH39_24195	COG1506	peptidase
KIH39_24235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KIH39_24255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KIH39_24280	COG4537	Required for transformation and DNA binding
KIH39_24285	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
KIH39_24305	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KIH39_24310	COG0673	inositol 2-dehydrogenase activity
KIH39_24315	COG0612	Peptidase, M16
KIH39_24345	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KIH39_24350	COG0673	inositol 2-dehydrogenase activity
KIH39_24365	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
KIH39_24375	COG1192	Involved in chromosome partitioning
KIH39_24385	COG4122	O-methyltransferase activity
KIH39_24390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KIH39_24400	COG0529	Catalyzes the synthesis of activated sulfate
KIH39_24415	COG4464	protein tyrosine phosphatase activity
KIH39_24425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KIH39_24430	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KIH39_24435	COG0667	Aldo Keto reductase
KIH39_24460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_24505	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KIH39_24510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_24525	COG4555	ABC transporter
KIH39_24530	COG0616	signal peptide processing
KIH39_24535	COG0285	dihydrofolate synthase activity
KIH39_24550	COG1136	(ABC) transporter
KIH39_24550	COG0577	efflux transmembrane transporter activity
KIH39_24560	COG0577	efflux transmembrane transporter activity
KIH39_24560	COG1136	(ABC) transporter
KIH39_24565	COG1136	(ABC) transporter
KIH39_24565	COG0577	efflux transmembrane transporter activity
KIH39_24575	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KIH39_24595	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KIH39_24600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KIH39_24610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KIH39_24615	COG0640	Transcriptional regulator
KIH39_24620	COG3069	C4-dicarboxylate transmembrane transporter activity
KIH39_24640	COG0508	dehydrogenase complex catalyzes the overall conversion of
KIH39_24645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KIH39_24660	COG3958	Transketolase
KIH39_24665	COG3959	Transketolase, thiamine diphosphate binding domain
KIH39_24680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KIH39_24690	COG0443	Heat shock 70 kDa protein
KIH39_24695	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KIH39_24720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIH39_24725	COG0542	response to heat
KIH39_24760	COG0372	Belongs to the citrate synthase family
KIH39_24770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KIH39_24800	COG0463	Glycosyl transferase, family 2
KIH39_24820	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KIH39_24825	COG0148	phosphopyruvate hydratase activity
KIH39_24835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KIH39_24840	COG0322	excinuclease ABC activity
KIH39_24870	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KIH39_24915	COG0386	Belongs to the glutathione peroxidase family
KIH39_24920	COG0612	Peptidase, M16
KIH39_24935	COG1028	Short-chain dehydrogenase reductase Sdr
KIH39_24945	COG0776	regulation of translation
KIH39_24955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KIH39_25000	COG0515	serine threonine protein kinase
KIH39_25005	COG0167	dihydroorotate dehydrogenase activity
KIH39_25010	COG1253	flavin adenine dinucleotide binding
KIH39_25015	COG1994	Peptidase M50
KIH39_25040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KIH39_25045	COG0594	ribonuclease P activity
KIH39_25050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KIH39_25055	COG1028	Short-chain dehydrogenase reductase Sdr
KIH39_25085	COG0724	RNA recognition motif
KIH39_25130	COG2140	Oxalate decarboxylase
KIH39_25160	COG0408	coproporphyrinogen oxidase activity
KIH39_25175	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KIH39_25190	COG3541	Predicted nucleotidyltransferase
KIH39_25215	COG0129	dihydroxy-acid dehydratase activity
KIH39_25290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KIH39_25300	COG4948	Mandelate Racemase Muconate Lactonizing
KIH39_25330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KIH39_25335	COG1185	polyribonucleotide nucleotidyltransferase activity
KIH39_25340	COG2165	general secretion pathway protein
KIH39_25375	COG0585	pseudouridine synthase activity
KIH39_25380	COG1012	belongs to the aldehyde dehydrogenase family
KIH39_25405	COG4948	Mandelate Racemase Muconate Lactonizing
KIH39_25415	COG3119	arylsulfatase activity
KIH39_25505	COG2211	Major facilitator Superfamily
KIH39_25570	COG0180	Tryptophanyl-tRNA synthetase
KIH39_25590	COG2081	HI0933 family
KIH39_25605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KIH39_25635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KIH39_25645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KIH39_25655	COG0564	pseudouridine synthase activity
KIH39_25665	COG4336	lyase activity
KIH39_25695	COG0154	amidase activity
KIH39_25700	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KIH39_25705	COG0586	Pfam SNARE associated Golgi protein
KIH39_25710	COG0156	8-amino-7-oxononanoate synthase activity
KIH39_25725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KIH39_25730	COG1030	water channel activity
KIH39_25740	COG4864	UPF0365 protein
KIH39_25755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KIH39_25770	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KIH39_25775	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KIH39_25780	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KIH39_25785	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KIH39_25790	COG0202	RNA polymerase activity
KIH39_25795	COG0203	ribosomal protein L17
KIH39_25810	COG2195	Cleaves the N-terminal amino acid of tripeptides
KIH39_25835	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KIH39_25845	COG0187	DNA topoisomerase II activity
KIH39_25860	COG0515	serine threonine protein kinase
KIH39_25860	COG2815	serine threonine protein kinase
KIH39_25865	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KIH39_25900	COG0602	queuosine metabolic process
KIH39_25925	COG0861	Integral membrane protein TerC family
KIH39_25960	COG0012	GTP binding
KIH39_25965	COG0714	Associated with various cellular activities
KIH39_25985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KIH39_25990	COG1674	ftsk spoiiie
KIH39_25995	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KIH39_26005	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KIH39_26010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KIH39_26015	COG0085	RNA polymerase activity
KIH39_26020	COG0222	ribosome binding
KIH39_26025	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KIH39_26030	COG0081	regulation of translation
KIH39_26035	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KIH39_26045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KIH39_26050	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KIH39_26065	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KIH39_26080	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KIH39_26100	COG3481	metal-dependent phosphohydrolase, HD sub domain
KIH39_26175	COG0564	pseudouridine synthase activity
KIH39_26180	COG0646	methionine synthase
KIH39_26180	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KIH39_26185	COG0405	Gamma-glutamyltransferase
KIH39_26200	COG0556	nucleotide-excision repair
KIH39_26215	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KIH39_26225	COG3104	oligopeptide transport
KIH39_26235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KIH39_26250	COG0205	6-phosphofructokinase activity
KIH39_26260	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KIH39_26265	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KIH39_26275	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KIH39_26280	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KIH39_26285	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KIH39_26290	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KIH39_26300	COG0356	it plays a direct role in the translocation of protons across the membrane
KIH39_26315	COG1166	arginine decarboxylase activity
KIH39_26345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair