locus-tag	class	description
AUW17_00005	COG0557	exoribonuclease II activity
AUW17_00015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AUW17_00020	COG0393	Putative heavy-metal-binding
AUW17_00040	COG0445	tRNA wobble uridine modification
AUW17_00045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AUW17_00055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AUW17_00070	COG0420	3'-5' exonuclease activity
AUW17_00075	COG0419	ATPase involved in DNA repair
AUW17_00095	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AUW17_00110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AUW17_00110	COG0758	DNA mediated transformation
AUW17_00130	COG4067	protein conserved in archaea
AUW17_00130	COG0189	ligase activity
AUW17_00135	COG0746	molybdenum cofactor guanylyltransferase activity
AUW17_00140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AUW17_00150	COG2827	Endonuclease containing a URI domain
AUW17_00155	COG0303	'Molybdopterin
AUW17_00160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AUW17_00165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AUW17_00170	COG0322	excinuclease ABC activity
AUW17_00175	COG1752	Esterase of the alpha-beta hydrolase superfamily
AUW17_00180	COG1530	ribonuclease E activity
AUW17_00185	COG0776	regulation of translation
AUW17_00205	COG1629	transport
AUW17_00205	COG4206	TonB-dependent receptor
AUW17_00215	COG0629	single-stranded DNA binding
AUW17_00250	COG0612	Peptidase, M16
AUW17_00255	COG0612	Peptidase, M16
AUW17_00260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AUW17_00265	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AUW17_00270	COG3279	Response regulator of the LytR AlgR family
AUW17_00275	COG2972	Histidine kinase
AUW17_00275	COG0745	RESPONSE REGULATOR receiver
AUW17_00285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AUW17_00290	COG1418	mRNA catabolic process
AUW17_00295	COG1024	Enoyl-CoA hydratase
AUW17_00320	COG0470	DNA polymerase III
AUW17_00355	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AUW17_00370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AUW17_00380	COG0489	protein tyrosine kinase activity
AUW17_00390	COG0492	ferredoxin-NADP+ reductase activity
AUW17_00400	COG0633	Ferredoxin
AUW17_00405	COG2116	formate transmembrane transporter activity
AUW17_00410	COG0716	FMN binding
AUW17_00435	COG1607	acyl-coa hydrolase
AUW17_00440	COG0628	permease
AUW17_00460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AUW17_00475	COG0488	(ABC) transporter
AUW17_00485	COG0745	RESPONSE REGULATOR receiver
AUW17_00490	COG5002	protein histidine kinase activity
AUW17_00505	COG0793	Belongs to the peptidase S41A family
AUW17_00510	COG0594	ribonuclease P activity
AUW17_00535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AUW17_00540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AUW17_00545	COG0193	aminoacyl-tRNA hydrolase activity
AUW17_00560	COG0720	synthase
AUW17_00570	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AUW17_00575	COG0534	Mate efflux family protein
AUW17_00580	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AUW17_00590	COG4585	Histidine kinase
AUW17_00600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AUW17_00605	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AUW17_00610	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AUW17_00615	COG3483	tryptophan 2,3-dioxygenase activity
AUW17_00625	COG0739	heme binding
AUW17_00630	COG0166	Belongs to the GPI family
AUW17_00670	COG0314	molybdopterin synthase activity
AUW17_00675	COG0126	phosphoglycerate kinase activity
AUW17_00680	COG0667	Aldo Keto reductase
AUW17_00695	COG2885	chlorophyll binding
AUW17_00695	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AUW17_00705	COG0180	Tryptophanyl-tRNA synthetase
AUW17_00715	COG1272	protein, Hemolysin III
AUW17_00790	COG0840	transmembrane signaling receptor activity
AUW17_00800	COG0632	four-way junction helicase activity
AUW17_00810	COG0509	glycine decarboxylation via glycine cleavage system
AUW17_00835	COG0463	Glycosyl transferase, family 2
AUW17_00840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AUW17_00865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AUW17_00880	COG1858	cytochrome C peroxidase
AUW17_00890	COG4771	TonB-dependent receptor
AUW17_00905	COG0495	leucyl-tRNA aminoacylation
AUW17_00925	COG1946	Acyl-CoA thioesterase
AUW17_00930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AUW17_00930	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AUW17_00940	COG1970	mechanosensitive ion channel activity
AUW17_00945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AUW17_00950	COG1435	thymidine kinase activity
AUW17_00970	COG0779	Required for maturation of 30S ribosomal subunits
AUW17_00975	COG0195	Participates in both transcription termination and antitermination
AUW17_00980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AUW17_01175	COG4771	TonB-dependent receptor
AUW17_01185	COG0803	Belongs to the bacterial solute-binding protein 9 family
AUW17_01190	COG1121	(ABC) transporter
AUW17_01195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AUW17_01200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AUW17_01205	COG1074	ATP-dependent DNA helicase activity
AUW17_01210	COG0156	8-amino-7-oxononanoate synthase activity
AUW17_01215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AUW17_01215	COG2885	chlorophyll binding
AUW17_01220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AUW17_01230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AUW17_01240	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AUW17_01245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AUW17_01255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AUW17_01270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AUW17_01275	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AUW17_01285	COG0156	8-amino-7-oxononanoate synthase activity
AUW17_01305	COG0508	dehydrogenase complex catalyzes the overall conversion of
AUW17_01310	COG1012	belongs to the aldehyde dehydrogenase family
AUW17_01315	COG0564	pseudouridine synthase activity
AUW17_01320	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AUW17_01325	COG2267	carboxylic ester hydrolase activity
AUW17_01330	COG2001	Belongs to the MraZ family
AUW17_01335	COG0275	rRNA processing
AUW17_01345	COG0768	penicillin binding
AUW17_01350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AUW17_01355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AUW17_01360	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AUW17_01365	COG0772	Belongs to the SEDS family
AUW17_01370	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AUW17_01375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AUW17_01390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AUW17_01395	COG1610	YqeY-like protein
AUW17_01410	COG0517	IMP dehydrogenase activity
AUW17_01415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AUW17_01420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AUW17_01425	COG1595	DNA-templated transcription, initiation
AUW17_01430	COG1595	DNA-templated transcription, initiation
AUW17_01450	COG2226	methyltransferase
AUW17_01455	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AUW17_01470	COG0442	prolyl-tRNA aminoacylation
AUW17_01485	COG0268	Binds directly to 16S ribosomal RNA
AUW17_01500	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AUW17_01505	COG1968	undecaprenyl-diphosphatase activity
AUW17_01515	COG2177	Part of the ABC transporter FtsEX involved in
AUW17_01520	COG0346	lactoylglutathione lyase activity
AUW17_01525	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AUW17_01550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AUW17_01560	COG0431	NADPH-dependent FMN reductase
AUW17_01570	COG0481	GTPase activity
AUW17_01585	COG1629	transport
AUW17_01585	COG4206	TonB-dependent receptor
AUW17_01600	COG0252	asparaginase activity
AUW17_01605	COG0811	peptide transport
AUW17_01615	COG0848	biopolymer transport protein
AUW17_01635	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AUW17_01640	COG0017	Asparaginyl-tRNA synthetase
AUW17_01655	COG0233	cytoplasmic translational termination
AUW17_01660	COG0528	UMP kinase activity
AUW17_01665	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AUW17_01670	COG0052	Belongs to the universal ribosomal protein uS2 family
AUW17_01675	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AUW17_01680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AUW17_01690	COG1477	protein flavinylation
AUW17_01695	COG2226	methyltransferase
AUW17_01710	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AUW17_01715	COG0501	Belongs to the peptidase M48B family
AUW17_01720	COG3186	Phenylalanine-4-hydroxylase
AUW17_01770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AUW17_01780	COG0702	epimerase
AUW17_01785	COG0386	Belongs to the glutathione peroxidase family
AUW17_01795	COG0415	Belongs to the DNA photolyase family
AUW17_01800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AUW17_01815	COG1629	transport
AUW17_01815	COG4206	TonB-dependent receptor
AUW17_01850	COG3540	Alkaline phosphatase
AUW17_01860	COG2363	Small membrane protein
AUW17_01870	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AUW17_01875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AUW17_01880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AUW17_01895	COG1160	GTP binding
AUW17_01905	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AUW17_01940	COG2423	ornithine cyclodeaminase activity
AUW17_01950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AUW17_01960	COG0653	protein targeting
AUW17_01965	COG0006	proline dipeptidase activity
AUW17_01970	COG0006	proline dipeptidase activity
AUW17_01975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AUW17_01985	COG3938	Belongs to the proline racemase family
AUW17_01995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AUW17_02010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AUW17_02030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AUW17_02040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AUW17_02050	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AUW17_02055	COG0596	Alpha beta hydrolase
AUW17_02060	COG1950	PFAM Membrane protein of
AUW17_02065	COG0544	peptidyl-prolyl cis-trans isomerase activity
AUW17_02075	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AUW17_02085	COG0358	DNA primase activity
AUW17_02090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AUW17_02105	COG1428	Deoxynucleoside kinase
AUW17_02115	COG1185	polyribonucleotide nucleotidyltransferase activity
AUW17_02120	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AUW17_02125	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AUW17_02130	COG0191	fructose-bisphosphate aldolase activity
AUW17_02140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AUW17_02145	COG1428	Deoxynucleoside kinase
AUW17_02155	COG0321	lipoyl(octanoyl) transferase activity
AUW17_02165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AUW17_02185	COG1490	D-aminoacyl-tRNA deacylase activity
AUW17_02190	COG1162	GTPase activity
AUW17_02195	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AUW17_02200	COG0287	Prephenate dehydrogenase
AUW17_02200	COG1605	Chorismate mutase
AUW17_02265	COG0857	belongs to the CobB CobQ family
AUW17_02265	COG0280	phosphate acetyltransferase
AUW17_02270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AUW17_02275	COG0101	tRNA pseudouridine synthase activity
AUW17_02280	COG1960	acyl-CoA dehydrogenase activity
AUW17_02285	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AUW17_02295	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AUW17_02315	COG0285	dihydrofolate synthase activity
AUW17_02360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AUW17_02365	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AUW17_02380	COG1086	Polysaccharide biosynthesis protein
AUW17_02410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AUW17_02415	COG0110	maltose O-acetyltransferase activity
AUW17_02420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AUW17_02425	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AUW17_02450	COG0519	Catalyzes the synthesis of GMP from XMP
AUW17_02450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AUW17_02455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AUW17_02460	COG0295	cytidine deaminase activity
AUW17_02475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AUW17_02490	COG1333	cytochrome c biogenesis protein
AUW17_02490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AUW17_02495	COG0688	phosphatidylethanolamine metabolic process
AUW17_02500	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AUW17_02500	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AUW17_02505	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AUW17_02540	COG1917	Cupin 2, conserved barrel domain protein
AUW17_02540	COG2207	Transcriptional regulator
AUW17_02545	COG4716	Myosin-crossreactive antigen
AUW17_02570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AUW17_02575	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AUW17_02585	COG1132	(ABC) transporter
AUW17_02590	COG0101	tRNA pseudouridine synthase activity
AUW17_02600	COG4585	Histidine kinase
AUW17_02625	COG2197	response regulator
AUW17_02640	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AUW17_02645	COG2315	Protein conserved in bacteria
AUW17_02655	COG0492	ferredoxin-NADP+ reductase activity
AUW17_02670	COG2866	Carboxypeptidase
AUW17_02680	COG3579	cysteine-type endopeptidase activity
AUW17_02900	COG3392	D12 class N6 adenine-specific DNA methyltransferase
AUW17_02920	COG1215	transferase activity, transferring glycosyl groups
AUW17_02930	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AUW17_02930	COG2885	chlorophyll binding
AUW17_02945	COG0259	pyridoxamine-phosphate oxidase activity
AUW17_02955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AUW17_02960	COG0105	UTP biosynthetic process
AUW17_02970	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AUW17_02985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AUW17_02990	COG0671	phosphoesterase, PA-phosphatase related
AUW17_03000	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AUW17_03030	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AUW17_03080	COG2885	chlorophyll binding
AUW17_03080	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AUW17_03190	COG0616	signal peptide processing
AUW17_03320	COG3279	Response regulator of the LytR AlgR family
AUW17_03325	COG3275	phosphorelay sensor kinase activity
AUW17_03335	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AUW17_03355	COG4771	TonB-dependent receptor
AUW17_03365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AUW17_03370	COG1595	DNA-templated transcription, initiation
AUW17_03375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AUW17_03380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AUW17_03395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AUW17_03410	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AUW17_03425	COG0681	Belongs to the peptidase S26 family
AUW17_03430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AUW17_03440	COG0592	DNA-directed DNA polymerase activity
AUW17_03470	COG1104	cysteine desulfurase activity
AUW17_03485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AUW17_03490	COG1663	tetraacyldisaccharide 4'-kinase activity
AUW17_03495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AUW17_03500	COG1136	(ABC) transporter
AUW17_03510	COG0045	succinate-CoA ligase (ADP-forming) activity
AUW17_03530	COG0556	nucleotide-excision repair
AUW17_03550	COG1278	Cold shock
AUW17_03555	COG1278	Cold shock
AUW17_03560	COG1278	Cold shock
AUW17_03565	COG4895	conserved protein (DUF2196)
AUW17_03585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AUW17_03595	COG2329	Antibiotic biosynthesis monooxygenase
AUW17_03600	COG4166	transmembrane transport
AUW17_03620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AUW17_03630	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AUW17_03640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AUW17_03655	COG0300	oxidoreductase activity
AUW17_03660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AUW17_03665	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AUW17_03670	COG2996	Protein conserved in bacteria
AUW17_03690	COG1546	Belongs to the CinA family
AUW17_03690	COG1058	Belongs to the CinA family
AUW17_03695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AUW17_03700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AUW17_03705	COG0552	protein localization to endoplasmic reticulum
AUW17_03715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AUW17_03720	COG0443	Heat shock 70 kDa protein
AUW17_03745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AUW17_03770	COG1702	phosphate starvation-inducible protein PhoH
AUW17_03780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AUW17_03790	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AUW17_03800	COG0156	8-amino-7-oxononanoate synthase activity
AUW17_03845	COG1482	cell wall glycoprotein biosynthetic process
AUW17_03855	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AUW17_03870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AUW17_03890	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AUW17_03935	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AUW17_03935	COG0321	lipoyl(octanoyl) transferase activity
AUW17_03940	COG3022	response to hydroperoxide
AUW17_03945	COG2949	membrane
AUW17_03950	COG1760	l-serine dehydratase
AUW17_03970	COG0205	6-phosphofructokinase activity
AUW17_03975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AUW17_03980	COG0251	oxidation-reduction process
AUW17_03985	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AUW17_03990	COG0860	N-Acetylmuramoyl-L-alanine amidase
AUW17_04000	COG2181	nitrate reductase activity
AUW17_04000	COG0247	lactate metabolic process
AUW17_04005	COG2181	nitrate reductase activity
AUW17_04005	COG0247	lactate metabolic process
AUW17_04015	COG1575	Belongs to the MenA family. Type 1 subfamily
AUW17_04020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AUW17_04030	COG4948	Mandelate Racemase Muconate Lactonizing
AUW17_04035	COG1266	CAAX protease self-immunity
AUW17_04050	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AUW17_04055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AUW17_04060	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AUW17_04065	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AUW17_04070	COG1841	ribosomal large subunit assembly
AUW17_04075	COG0200	Binds to the 23S rRNA
AUW17_04080	COG0201	protein transport
AUW17_04085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AUW17_04090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AUW17_04095	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AUW17_04100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AUW17_04105	COG0202	RNA polymerase activity
AUW17_04110	COG0203	ribosomal protein L17
AUW17_04115	COG0505	Belongs to the CarA family
AUW17_04120	COG1629	transport
AUW17_04120	COG4206	TonB-dependent receptor
AUW17_04135	COG0612	Peptidase, M16
AUW17_04140	COG0148	phosphopyruvate hydratase activity
AUW17_04150	COG0010	Belongs to the arginase family
AUW17_04160	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AUW17_04170	COG0351	phosphomethylpyrimidine kinase
AUW17_04175	COG0352	thiamine-phosphate diphosphorylase activity
AUW17_04180	COG2022	thiamine diphosphate biosynthetic process
AUW17_04185	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AUW17_04210	COG0300	oxidoreductase activity
AUW17_04220	COG2234	aminopeptidase activity
AUW17_04225	COG1120	ATPase activity
AUW17_04230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AUW17_04235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AUW17_04245	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AUW17_04255	COG0339	signal peptide processing
AUW17_04260	COG1295	ribonuclease BN
AUW17_04265	COG0124	histidyl-tRNA synthetase
AUW17_04270	COG0302	gtp cyclohydrolase
AUW17_04275	COG1629	transport
AUW17_04275	COG4206	TonB-dependent receptor
AUW17_04310	COG1862	Preprotein translocase
AUW17_04320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AUW17_04330	COG1132	(ABC) transporter
AUW17_04340	COG1169	isochorismate synthase
AUW17_04345	COG2050	protein possibly involved in aromatic compounds catabolism
AUW17_04355	COG0009	L-threonylcarbamoyladenylate synthase
AUW17_04375	COG0488	(ABC) transporter
AUW17_04380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AUW17_04400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AUW17_04430	COG1418	mRNA catabolic process
AUW17_04435	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AUW17_04475	COG0335	large ribosomal subunit rRNA binding
AUW17_04480	COG0336	Belongs to the RNA methyltransferase TrmD family
AUW17_04485	COG0564	pseudouridine synthase activity
AUW17_04490	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AUW17_04495	COG2195	Cleaves the N-terminal amino acid of tripeptides
AUW17_04500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AUW17_04520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AUW17_04535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AUW17_04545	COG0113	porphobilinogen synthase activity
AUW17_04550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AUW17_04555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AUW17_04570	COG0408	coproporphyrinogen oxidase activity
AUW17_04575	COG0508	dehydrogenase complex catalyzes the overall conversion of
AUW17_04580	COG1090	epimerase
AUW17_04595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AUW17_04595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AUW17_04605	COG0215	cysteine-tRNA ligase activity
AUW17_04610	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AUW17_04615	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AUW17_04625	COG0590	tRNA wobble adenosine to inosine editing
AUW17_04650	COG0706	membrane insertase activity
AUW17_04655	COG0504	CTP synthase activity
AUW17_04660	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AUW17_04665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AUW17_04675	COG1607	acyl-coa hydrolase
AUW17_04705	COG4628	conserved protein (DUF2132)
AUW17_04720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AUW17_04725	COG1408	metallophosphoesterase
AUW17_04765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AUW17_04775	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AUW17_04780	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AUW17_04785	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
AUW17_04790	COG4206	TonB-dependent receptor
AUW17_04800	COG3011	Protein conserved in bacteria
AUW17_04805	COG1136	(ABC) transporter
AUW17_04810	COG0577	efflux transmembrane transporter activity
AUW17_04810	COG1136	(ABC) transporter
AUW17_04815	COG1136	(ABC) transporter
AUW17_04815	COG0577	efflux transmembrane transporter activity
AUW17_04825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AUW17_04830	COG4628	conserved protein (DUF2132)
AUW17_04835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AUW17_04840	COG1028	Short-chain dehydrogenase reductase Sdr
AUW17_04845	COG3956	TIGRFAM MazG family protein
AUW17_04855	COG0242	peptide deformylase activity
AUW17_04860	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AUW17_04865	COG2171	N-acyltransferase activity
AUW17_04870	COG0438	transferase activity, transferring glycosyl groups
AUW17_04875	COG1215	transferase activity, transferring glycosyl groups
AUW17_04900	COG0617	tRNA 3'-terminal CCA addition
AUW17_04905	COG1132	(ABC) transporter
AUW17_04910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AUW17_04915	COG0463	Glycosyl transferase, family 2
AUW17_04925	COG4974	Belongs to the 'phage' integrase family
AUW17_04940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AUW17_04955	COG1183	phosphatidylcholine synthase activity
AUW17_04960	COG1137	ATPase activity
AUW17_04970	COG0805	protein transport
AUW17_04980	COG0514	ATP-dependent DNA helicase (RecQ)
AUW17_04990	COG0686	Belongs to the AlaDH PNT family
AUW17_05000	COG2204	response regulator
AUW17_05005	COG1078	dGTPase activity
AUW17_05010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AUW17_05015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AUW17_05015	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AUW17_05020	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AUW17_05025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AUW17_05035	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AUW17_05050	COG2096	Adenosyltransferase
AUW17_05055	COG1797	cobyrinic acid a,c-diamide synthase activity
AUW17_05060	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AUW17_05070	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AUW17_05080	COG2875	Belongs to the precorrin methyltransferase family
AUW17_05090	COG0778	Nitroreductase
AUW17_05110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AUW17_05110	COG1648	precorrin-2 dehydrogenase activity
AUW17_05135	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AUW17_05140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AUW17_05145	COG1492	cobalamin metabolic process
AUW17_05150	COG1943	Transposase
AUW17_05175	COG3002	Belongs to the UPF0753 family
AUW17_05180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AUW17_05185	COG0659	secondary active sulfate transmembrane transporter activity
AUW17_05195	COG1401	restriction endodeoxyribonuclease activity
AUW17_05195	COG1401	restriction endodeoxyribonuclease activity
AUW17_05200	COG0732	type I restriction modification DNA specificity domain
AUW17_05235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AUW17_05330	COG0616	signal peptide processing
AUW17_05470	COG4804	nuclease activity
AUW17_05480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AUW17_05500	COG2885	chlorophyll binding
AUW17_05520	COG2373	Large extracellular alpha-helical protein
AUW17_05550	COG0527	aspartate kinase activity
AUW17_05550	COG0460	homoserine dehydrogenase
AUW17_05560	COG1959	2 iron, 2 sulfur cluster binding
AUW17_05570	COG0175	sulfate reduction
AUW17_05575	COG0175	sulfate reduction
AUW17_05585	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AUW17_05590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AUW17_05590	COG1648	precorrin-2 dehydrogenase activity
AUW17_05595	COG1648	precorrin-2 dehydrogenase activity
AUW17_05595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AUW17_05600	COG0492	ferredoxin-NADP+ reductase activity
AUW17_05605	COG1045	serine acetyltransferase
AUW17_05625	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AUW17_05635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AUW17_05640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AUW17_05645	COG0066	3-isopropylmalate dehydratase activity
AUW17_05650	COG0473	3-isopropylmalate dehydrogenase activity
AUW17_05665	COG0129	dihydroxy-acid dehydratase activity
AUW17_05670	COG0028	Belongs to the TPP enzyme family
AUW17_05680	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AUW17_05685	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AUW17_05690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AUW17_05700	COG0076	glutamate decarboxylase activity
AUW17_05705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AUW17_05715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AUW17_05725	COG0360	Binds together with S18 to 16S ribosomal RNA
AUW17_05730	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AUW17_05735	COG0359	binds to the 23S rRNA
AUW17_05745	COG2195	Cleaves the N-terminal amino acid of tripeptides
AUW17_05775	COG0438	transferase activity, transferring glycosyl groups
AUW17_05780	COG1250	3-hydroxyacyl-CoA dehydrogenase
AUW17_05790	COG0673	inositol 2-dehydrogenase activity
AUW17_05795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AUW17_05805	COG0813	purine-nucleoside phosphorylase activity
AUW17_05845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AUW17_05850	COG2885	chlorophyll binding
AUW17_05860	COG0668	transmembrane transport
AUW17_05865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AUW17_05870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AUW17_05870	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AUW17_05890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AUW17_05920	COG0513	Belongs to the DEAD box helicase family
AUW17_05930	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AUW17_05965	COG0210	DNA helicase
AUW17_05975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AUW17_05980	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AUW17_05985	COG0484	heat shock protein binding
AUW17_06010	COG1028	Short-chain dehydrogenase reductase Sdr
AUW17_06045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AUW17_06050	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AUW17_06055	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AUW17_06070	COG3958	Transketolase
AUW17_06075	COG0424	maF-like protein
AUW17_06085	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AUW17_06090	COG3047	cAMP biosynthetic process
AUW17_06095	COG0542	response to heat
AUW17_06115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AUW17_06150	COG1278	Cold shock
AUW17_06160	COG1278	Cold shock
AUW17_06170	COG1979	alcohol dehydrogenase
AUW17_06180	COG1309	transcriptional regulator
AUW17_06190	COG1522	sequence-specific DNA binding
AUW17_06195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AUW17_06205	COG0564	pseudouridine synthase activity
AUW17_06210	COG1522	sequence-specific DNA binding
AUW17_06230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AUW17_06235	COG0539	negative regulation of cytoplasmic translation
AUW17_06250	COG1739	Uncharacterized protein family UPF0029
AUW17_06255	COG0697	spore germination
AUW17_06260	COG1011	Hydrolase
AUW17_06265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AUW17_06265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AUW17_06275	COG2890	protein-(glutamine-N5) methyltransferase activity
AUW17_06290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AUW17_06310	COG0564	pseudouridine synthase activity
AUW17_06315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AUW17_06330	COG0167	dihydroorotate dehydrogenase activity
AUW17_06340	COG2356	endonuclease I
AUW17_06370	COG1363	Peptidase, m42
AUW17_06400	COG0488	(ABC) transporter
AUW17_06450	COG1607	acyl-coa hydrolase
AUW17_06480	COG4771	TonB-dependent receptor
AUW17_06485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AUW17_06545	COG1301	dicarboxylic acid transport
AUW17_06560	COG0668	transmembrane transport
AUW17_06585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AUW17_06585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AUW17_06585	COG1333	cytochrome c biogenesis protein
AUW17_06585	COG1333	cytochrome c biogenesis protein
AUW17_06590	COG0517	IMP dehydrogenase activity
AUW17_06590	COG0516	GMP reductase activity
AUW17_06650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AUW17_06685	COG3842	ATPase activity
AUW17_06690	COG1175	transmembrane transport
AUW17_06725	COG1840	ABC-type Fe3 transport system, periplasmic component
AUW17_06770	COG0525	valine-tRNA ligase activity
AUW17_06790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AUW17_06795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AUW17_06815	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AUW17_06840	COG3876	Protein conserved in bacteria
AUW17_06875	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AUW17_06885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AUW17_06885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AUW17_06915	COG0012	GTP binding
AUW17_06935	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AUW17_06940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AUW17_06945	COG3340	Belongs to the peptidase S51 family
AUW17_06975	COG0714	Associated with various cellular activities
AUW17_06980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AUW17_07000	COG0514	ATP-dependent DNA helicase (RecQ)
AUW17_07005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AUW17_07010	COG0776	regulation of translation
AUW17_07015	COG2249	NAD(P)H dehydrogenase (quinone) activity
AUW17_07020	COG0116	Belongs to the methyltransferase superfamily
AUW17_07040	COG0602	queuosine metabolic process
AUW17_07045	COG0825	malonyl-CoA metabolic process
AUW17_07060	COG0343	queuine tRNA-ribosyltransferase activity
AUW17_07065	COG1187	pseudouridine synthase activity
AUW17_07090	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AUW17_07095	COG0564	pseudouridine synthase activity
AUW17_07105	COG1181	Belongs to the D-alanine--D-alanine ligase family
AUW17_07110	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AUW17_07135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AUW17_07150	COG0745	RESPONSE REGULATOR receiver
AUW17_07195	COG3279	Response regulator of the LytR AlgR family
AUW17_07205	COG4251	negative regulation of phosphorylation
AUW17_07215	COG4251	negative regulation of phosphorylation
AUW17_07225	COG0784	Response regulator, receiver
AUW17_07255	COG0243	molybdopterin cofactor binding
AUW17_07275	COG3012	SEC-C Motif Domain Protein
AUW17_07280	COG0527	aspartate kinase activity
AUW17_07280	COG0460	homoserine dehydrogenase
AUW17_07285	COG0083	homoserine kinase activity
AUW17_07290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AUW17_07295	COG1022	Amp-dependent synthetase and ligase
AUW17_07300	COG0564	pseudouridine synthase activity
AUW17_07305	COG2270	Major facilitator Superfamily
AUW17_07325	COG1629	transport
AUW17_07325	COG4206	TonB-dependent receptor
AUW17_07330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AUW17_07340	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AUW17_07345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AUW17_07355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AUW17_07365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AUW17_07370	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AUW17_07390	COG0140	phosphoribosyl-ATP diphosphatase activity
AUW17_07390	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AUW17_07395	COG0107	imidazoleglycerol-phosphate synthase activity
AUW17_07400	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AUW17_07410	COG0131	Imidazoleglycerol-phosphate dehydratase
AUW17_07415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AUW17_07420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AUW17_07425	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AUW17_07445	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AUW17_07450	COG1228	amidohydrolase
AUW17_07465	COG0010	Belongs to the arginase family
AUW17_07500	COG3279	Response regulator of the LytR AlgR family
AUW17_07505	COG2972	Histidine kinase
AUW17_07525	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AUW17_07530	COG1393	Belongs to the ArsC family
AUW17_07540	COG0463	Glycosyl transferase, family 2
AUW17_07540	COG1216	Glycosyl transferase, family 2
AUW17_07550	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AUW17_07555	COG0497	DNA recombination
AUW17_07585	COG1528	Iron-storage protein
AUW17_07590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AUW17_07610	COG4974	Belongs to the 'phage' integrase family
AUW17_07665	COG1506	peptidase
AUW17_07725	COG2161	toxin-antitoxin pair type II binding
AUW17_07730	COG4115	mRNA cleavage
AUW17_07835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AUW17_07840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AUW17_07850	COG0280	phosphate acetyltransferase
AUW17_07875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AUW17_07885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AUW17_07890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AUW17_07900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AUW17_07940	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AUW17_07945	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AUW17_07950	COG0824	Thioesterase
AUW17_07955	COG2096	Adenosyltransferase
AUW17_07965	COG0653	protein targeting
AUW17_07980	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AUW17_07990	COG1620	l-lactate permease
AUW17_07995	COG1304	FMN binding
AUW17_08020	COG0534	Mate efflux family protein
AUW17_08050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AUW17_08050	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AUW17_08060	COG0482	sulfurtransferase activity
AUW17_08075	COG3118	belongs to the thioredoxin family
AUW17_08085	COG0018	arginyl-trna synthetase
AUW17_08090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AUW17_08145	COG0488	(ABC) transporter
AUW17_08155	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AUW17_08160	COG0446	pyridine nucleotide-disulphide oxidoreductase
AUW17_08160	COG1902	pentaerythritol trinitrate reductase activity
AUW17_08180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AUW17_08190	COG0217	transcriptional regulatory protein
AUW17_08365	COG3620	sequence-specific DNA binding
AUW17_08395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AUW17_08400	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AUW17_08405	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AUW17_08410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AUW17_08415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AUW17_08420	COG0255	Belongs to the universal ribosomal protein uL29 family
AUW17_08425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AUW17_08430	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AUW17_08435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AUW17_08440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AUW17_08445	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AUW17_08450	COG0089	rRNA binding
AUW17_08455	COG0088	Forms part of the polypeptide exit tunnel
AUW17_08460	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AUW17_08465	COG0051	transcription antitermination factor activity, RNA binding
AUW17_08470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AUW17_08475	COG0049	tRNA binding
AUW17_08480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AUW17_08485	COG1629	transport
AUW17_08485	COG4206	TonB-dependent receptor
AUW17_08495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AUW17_08505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AUW17_08520	COG2003	Belongs to the UPF0758 family
AUW17_08525	COG0569	domain protein
AUW17_08530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AUW17_08545	COG2274	protein secretion by the type I secretion system
AUW17_08570	COG0662	Cupin 2, conserved barrel domain protein
AUW17_08590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AUW17_08595	COG3844	kynureninase activity
AUW17_08605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AUW17_08615	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AUW17_08615	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AUW17_08620	COG0076	glutamate decarboxylase activity
AUW17_08630	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AUW17_08630	COG2885	chlorophyll binding
AUW17_08645	COG2885	chlorophyll binding
AUW17_08645	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AUW17_08660	COG2813	Specifically methylates the guanine in position
AUW17_08665	COG0069	glutamate synthase activity
AUW17_08670	COG0254	rRNA binding
AUW17_08710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AUW17_08715	COG1917	Cupin 2, conserved barrel domain protein
AUW17_08715	COG2207	Transcriptional regulator
AUW17_08720	COG0730	response to heat
AUW17_08725	COG1858	cytochrome C peroxidase
AUW17_08735	COG1253	flavin adenine dinucleotide binding
AUW17_08740	COG0783	Belongs to the Dps family
AUW17_08750	COG0659	secondary active sulfate transmembrane transporter activity
AUW17_08760	COG0540	Belongs to the ATCase OTCase family
AUW17_08775	COG1234	tRNA 3'-trailer cleavage
AUW17_08790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AUW17_08795	COG0326	Molecular chaperone. Has ATPase activity
AUW17_08805	COG1629	transport
AUW17_08805	COG4206	TonB-dependent receptor
AUW17_08860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AUW17_08875	COG1472	Belongs to the glycosyl hydrolase 3 family
AUW17_08935	COG0443	Heat shock 70 kDa protein
AUW17_08940	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AUW17_08950	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AUW17_08950	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AUW17_08955	COG0799	negative regulation of ribosome biogenesis
AUW17_08960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AUW17_08970	COG4589	Belongs to the CDS family
AUW17_09005	COG0277	FAD linked oxidase domain protein
AUW17_09005	COG0247	lactate metabolic process
AUW17_09020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AUW17_09035	COG2373	Large extracellular alpha-helical protein
AUW17_09055	COG1404	Belongs to the peptidase S8 family
AUW17_09060	COG2234	aminopeptidase activity
AUW17_09065	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AUW17_09075	COG3530	Putative quorum-sensing-regulated virulence factor
AUW17_09115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AUW17_09150	COG2072	flavoprotein involved in K transport
AUW17_09180	COG0589	response to stress
AUW17_09195	COG0348	domain, Protein
AUW17_09225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AUW17_09235	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AUW17_09260	COG1842	Phage shock protein A
AUW17_09270	COG1396	sequence-specific DNA binding
AUW17_09280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AUW17_09285	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AUW17_09295	COG2217	Heavy metal translocating P-type atpase
AUW17_09310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AUW17_09315	COG0085	RNA polymerase activity
AUW17_09320	COG0222	ribosome binding
AUW17_09325	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AUW17_09330	COG0081	regulation of translation
AUW17_09335	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AUW17_09385	COG4974	Belongs to the 'phage' integrase family
AUW17_09390	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AUW17_09395	COG1960	acyl-CoA dehydrogenase activity
AUW17_09405	COG1115	amino acid carrier protein
AUW17_09445	COG1611	Belongs to the LOG family
AUW17_09465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AUW17_09475	COG2816	NAD+ diphosphatase activity
AUW17_09480	COG0778	Nitroreductase
AUW17_09485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AUW17_09510	COG0450	alkyl hydroperoxide reductase
AUW17_09520	COG3264	Mechanosensitive ion channel
AUW17_09520	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AUW17_09525	COG1668	transmembrane transport
AUW17_09530	COG4152	abc transporter atp-binding protein
AUW17_09535	COG1846	Transcriptional regulator
AUW17_09540	COG1024	Enoyl-CoA hydratase
AUW17_09540	COG1250	3-hydroxyacyl-CoA dehydrogenase
AUW17_09545	COG0183	Belongs to the thiolase family
AUW17_09550	COG1960	acyl-CoA dehydrogenase activity
AUW17_09565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AUW17_09575	COG0174	glutamine synthetase
AUW17_09665	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AUW17_09670	COG2264	protein methyltransferase activity
AUW17_09675	COG0149	triose-phosphate isomerase activity
AUW17_09685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AUW17_09700	COG0284	orotidine-5'-phosphate decarboxylase activity
AUW17_09710	COG1629	transport
AUW17_09710	COG4206	TonB-dependent receptor
AUW17_09715	COG3279	Response regulator of the LytR AlgR family
AUW17_09730	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AUW17_09735	COG2986	histidine ammonia-lyase
AUW17_09740	COG0583	DNA-binding transcription factor activity
AUW17_09750	COG1703	isobutyryl-CoA mutase activity
AUW17_09750	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AUW17_09750	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AUW17_09770	COG0159	tryptophan synthase activity
AUW17_09775	COG0133	tryptophan synthase activity
AUW17_09780	COG0135	phosphoribosylanthranilate isomerase activity
AUW17_09785	COG0134	indole-3-glycerol-phosphate synthase activity
AUW17_09790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AUW17_09795	COG0512	Glutamine amidotransferase of anthranilate synthase
AUW17_09800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AUW17_09805	COG0367	asparagine synthase
AUW17_09810	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AUW17_09815	COG0187	DNA topoisomerase II activity
AUW17_09830	COG2884	Cell division ATP-binding protein ftsE
AUW17_09850	COG0545	Peptidyl-prolyl cis-trans isomerase
AUW17_09855	COG1595	DNA-templated transcription, initiation
AUW17_09870	COG1127	ABC transporter
AUW17_09875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AUW17_09910	COG0183	Belongs to the thiolase family
AUW17_09915	COG0791	NLP P60 protein
AUW17_09925	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AUW17_09930	COG0542	response to heat
AUW17_09935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AUW17_09960	COG2733	membrane
AUW17_09980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AUW17_09990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AUW17_10005	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AUW17_10020	COG0732	type I restriction modification DNA specificity domain
AUW17_10025	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AUW17_10075	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AUW17_10080	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AUW17_10110	COG4191	Histidine kinase
AUW17_10120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AUW17_10130	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AUW17_10145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AUW17_10150	COG0339	signal peptide processing
AUW17_10215	COG1253	flavin adenine dinucleotide binding
AUW17_10240	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AUW17_10270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AUW17_10280	COG1388	LysM domain
AUW17_10280	COG1705	Flagellar rod assembly protein muramidase FlgJ
AUW17_10295	COG0488	(ABC) transporter
AUW17_10325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AUW17_10330	COG0010	Belongs to the arginase family
AUW17_10340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AUW17_10345	COG3604	Transcriptional regulator
AUW17_10360	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AUW17_10365	COG0459	protein refolding
AUW17_10380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AUW17_10385	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AUW17_10405	COG2814	Major facilitator Superfamily
AUW17_10415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AUW17_10425	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AUW17_10430	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AUW17_10435	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AUW17_10440	COG2363	Small membrane protein
AUW17_10460	COG1943	Transposase
AUW17_10465	COG1271	oxidase subunit
AUW17_10470	COG1294	oxidase, subunit
AUW17_10480	COG2267	carboxylic ester hydrolase activity
AUW17_10485	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AUW17_10490	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AUW17_10490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AUW17_10495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AUW17_10525	COG0519	Catalyzes the synthesis of GMP from XMP
AUW17_10530	COG0616	signal peptide processing
AUW17_10535	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AUW17_10580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AUW17_10585	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AUW17_10590	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AUW17_10595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AUW17_10610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AUW17_10615	COG0563	adenylate kinase activity
AUW17_10620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AUW17_10625	COG0791	NLP P60 protein
AUW17_10630	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AUW17_10640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AUW17_10645	COG0793	Belongs to the peptidase S41A family
AUW17_10660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AUW17_10665	COG0658	competence protein
AUW17_10665	COG2333	competence protein COMEC
AUW17_10675	COG3104	oligopeptide transport
AUW17_10680	COG3104	oligopeptide transport
AUW17_10685	COG1506	peptidase
AUW17_10685	COG0823	Involved in the tonB-independent uptake of proteins
AUW17_10700	COG2081	HI0933 family
AUW17_10725	COG1629	transport
AUW17_10725	COG4206	TonB-dependent receptor
AUW17_10790	COG0138	bifunctional purine biosynthesis protein purh
AUW17_10795	COG1077	Cell shape determining protein MreB Mrl
AUW17_10800	COG1792	Involved in formation and maintenance of cell shape
AUW17_10810	COG0768	penicillin binding
AUW17_10815	COG0772	Belongs to the SEDS family
AUW17_10885	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AUW17_10895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AUW17_10900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AUW17_10905	COG0511	ligase activity, forming carbon-carbon bonds
AUW17_10910	COG0439	Biotin carboxylase
AUW17_10915	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AUW17_10915	COG1519	Transferase
AUW17_10920	COG2391	methyltransferase activity
AUW17_10940	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AUW17_10960	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AUW17_10965	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AUW17_10980	COG3655	Transcriptional regulator
AUW17_10990	COG1522	sequence-specific DNA binding
AUW17_11005	COG0793	Belongs to the peptidase S41A family
AUW17_11005	COG3409	Peptidoglycan-binding domain 1 protein
AUW17_11010	COG3279	Response regulator of the LytR AlgR family
AUW17_11015	COG2205	protein histidine kinase activity
AUW17_11025	COG4942	peptidase
AUW17_11030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AUW17_11035	COG0194	GDP metabolic process
AUW17_11040	COG1561	YicC-like family, N-terminal region
AUW17_11050	COG1652	LysM domain
AUW17_11055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AUW17_11070	COG0719	Fe-S assembly protein
AUW17_11075	COG0396	ATPase activity
AUW17_11080	COG0719	Fe-S assembly protein
AUW17_11085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AUW17_11110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AUW17_11115	COG0668	transmembrane transport
AUW17_11120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AUW17_11130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AUW17_11140	COG1522	sequence-specific DNA binding
AUW17_11155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AUW17_11165	COG2824	Alkylphosphonate utilization operon protein PhnA
AUW17_11170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AUW17_11175	COG0228	four-way junction DNA binding
AUW17_11180	COG1278	Cold shock
AUW17_11210	COG0792	nuclease activity
AUW17_11215	COG1619	proteins homologs of microcin C7 resistance protein MccF
AUW17_11230	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AUW17_11230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AUW17_11245	COG2183	response to ionizing radiation
AUW17_11250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AUW17_11255	COG0629	single-stranded DNA binding
AUW17_11275	COG0469	pyruvate kinase activity
AUW17_11285	COG0571	ribonuclease III activity
AUW17_11290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AUW17_11295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AUW17_11305	COG3341	Caulimovirus viroplasmin
AUW17_11305	COG0328	RNA-DNA hybrid ribonuclease activity
AUW17_11320	COG0668	transmembrane transport
AUW17_11325	COG1214	PFAM Peptidase M22, glycoprotease
AUW17_11340	COG2322	membrane
AUW17_11345	COG1999	signal sequence binding
AUW17_11360	COG1845	cytochrome c oxidase, subunit III
AUW17_11370	COG0109	protoheme IX farnesyltransferase activity
AUW17_11425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AUW17_11430	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AUW17_11435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AUW17_11445	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AUW17_11450	COG2086	electron transfer activity
AUW17_11465	COG0022	dehydrogenase e1 component
AUW17_11465	COG0508	dehydrogenase complex catalyzes the overall conversion of
AUW17_11475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AUW17_11480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AUW17_11495	COG0037	tRNA processing
AUW17_11500	COG0785	Cytochrome C biogenesis protein
AUW17_11505	COG0606	chelatase, subunit chli
AUW17_11510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AUW17_11520	COG1528	Iron-storage protein
AUW17_11525	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AUW17_11550	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AUW17_11560	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AUW17_11575	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AUW17_11580	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AUW17_11595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AUW17_11615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AUW17_11640	COG1476	TRANSCRIPTIONal
AUW17_11645	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AUW17_11695	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AUW17_11705	COG0464	growth
AUW17_11750	COG0584	glycerophosphoryl diester phosphodiesterase
AUW17_11755	COG1288	antiporter activity
AUW17_11765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AUW17_11780	COG1999	signal sequence binding
AUW17_11785	COG0750	zinc metalloprotease
AUW17_11800	COG0527	aspartate kinase activity
AUW17_11810	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AUW17_11845	COG3118	belongs to the thioredoxin family
AUW17_11845	COG0492	ferredoxin-NADP+ reductase activity
AUW17_11850	COG1408	metallophosphoesterase
AUW17_11855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AUW17_11855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AUW17_11875	COG1040	competence protein
AUW17_11880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AUW17_11895	COG0423	glycine-tRNA ligase activity
AUW17_11915	COG2814	Major facilitator Superfamily
AUW17_11925	COG1381	Involved in DNA repair and RecF pathway recombination
AUW17_11945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AUW17_11945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AUW17_11955	COG2255	four-way junction helicase activity
AUW17_11960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AUW17_11990	COG0437	4 iron, 4 sulfur cluster binding
AUW17_12005	COG1253	flavin adenine dinucleotide binding
AUW17_12020	COG2151	metal-sulfur cluster biosynthetic enzyme
AUW17_12025	COG2166	iron-sulfur cluster assembly
AUW17_12035	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AUW17_12050	COG4771	TonB-dependent receptor
AUW17_12065	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AUW17_12070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AUW17_12080	COG0513	Belongs to the DEAD box helicase family
AUW17_12090	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AUW17_12095	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AUW17_12100	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AUW17_12105	COG1805	sodium ion transport
AUW17_12110	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AUW17_12120	COG2967	ApaG domain
AUW17_12145	COG1012	belongs to the aldehyde dehydrogenase family
AUW17_12150	COG0612	Peptidase, M16
AUW17_12155	COG0494	nUDIX hydrolase
AUW17_12165	COG0513	Belongs to the DEAD box helicase family
AUW17_12180	COG0357	Ribosomal RNA small subunit methyltransferase G
AUW17_12185	COG3239	Fatty acid desaturase
AUW17_12200	COG0084	hydrolase, TatD family'
AUW17_12215	COG0590	tRNA wobble adenosine to inosine editing
AUW17_12220	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AUW17_12230	COG0714	Associated with various cellular activities
AUW17_12245	COG2304	oxidoreductase activity
AUW17_12250	COG2304	oxidoreductase activity
AUW17_12280	COG0288	reversible hydration of carbon dioxide
AUW17_12285	COG0196	riboflavin kinase activity
AUW17_12295	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AUW17_12310	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AUW17_12315	COG2239	Acts as a magnesium transporter
AUW17_12325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AUW17_12350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AUW17_12355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AUW17_12360	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AUW17_12365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AUW17_12370	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AUW17_12375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AUW17_12380	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AUW17_12385	COG0356	it plays a direct role in the translocation of protons across the membrane
AUW17_12420	COG1388	LysM domain
AUW17_12420	COG0791	NLP P60 protein
AUW17_12425	COG0708	Exodeoxyribonuclease III
AUW17_12435	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AUW17_12440	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AUW17_12445	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AUW17_12465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AUW17_12475	COG0006	proline dipeptidase activity
AUW17_12480	COG0513	Belongs to the DEAD box helicase family
AUW17_12490	COG0189	ligase activity
AUW17_12510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AUW17_12535	COG2095	MarC family integral membrane protein
AUW17_12545	COG2356	endonuclease I
AUW17_12555	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AUW17_12560	COG1053	succinate dehydrogenase
AUW17_12570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AUW17_12570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AUW17_12585	COG1505	serine-type exopeptidase activity
AUW17_12590	COG3842	ATPase activity
AUW17_12595	COG3361	conserved protein (COG2071)
AUW17_12630	COG1012	belongs to the aldehyde dehydrogenase family
AUW17_12655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AUW17_12670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AUW17_12675	COG0756	dUTP diphosphatase activity
AUW17_12680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AUW17_12690	COG1187	pseudouridine synthase activity
AUW17_12700	COG2153	protein acetylation