locus-tag	class	description
HER15_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HER15_00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HER15_00015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HER15_00025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HER15_00030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HER15_00035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HER15_00040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HER15_00060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HER15_00090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HER15_00095	COG1528	Iron-storage protein
HER15_00125	COG0497	DNA recombination
HER15_00135	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HER15_00145	COG1216	Glycosyl transferase, family 2
HER15_00150	COG0612	Peptidase, M16
HER15_00155	COG2133	pyrroloquinoline quinone binding
HER15_00155	COG5183	chlorophyll binding
HER15_00220	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HER15_00230	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HER15_00240	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HER15_00250	COG1482	cell wall glycoprotein biosynthetic process
HER15_00260	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HER15_00265	COG1011	Hydrolase
HER15_00295	COG1595	DNA-templated transcription, initiation
HER15_00305	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HER15_00305	COG0321	lipoyl(octanoyl) transferase activity
HER15_00310	COG3022	response to hydroperoxide
HER15_00315	COG2949	membrane
HER15_00320	COG1760	l-serine dehydratase
HER15_00335	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HER15_00340	COG0205	6-phosphofructokinase activity
HER15_00345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HER15_00350	COG1803	Methylglyoxal synthase
HER15_00355	COG0251	oxidation-reduction process
HER15_00360	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HER15_00365	COG0860	N-Acetylmuramoyl-L-alanine amidase
HER15_00375	COG0247	lactate metabolic process
HER15_00375	COG2181	nitrate reductase activity
HER15_00380	COG2181	nitrate reductase activity
HER15_00380	COG0247	lactate metabolic process
HER15_00390	COG1575	Belongs to the MenA family. Type 1 subfamily
HER15_00400	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HER15_00415	COG1266	CAAX protease self-immunity
HER15_00430	COG0217	transcriptional regulatory protein
HER15_00440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HER15_00450	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HER15_00490	COG2388	GCN5-related N-acetyl-transferase
HER15_00500	COG1846	Transcriptional regulator
HER15_00510	COG0446	pyridine nucleotide-disulphide oxidoreductase
HER15_00510	COG1902	pentaerythritol trinitrate reductase activity
HER15_00520	COG0488	(ABC) transporter
HER15_00535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HER15_00540	COG0018	arginyl-trna synthetase
HER15_00590	COG0482	sulfurtransferase activity
HER15_00610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HER15_00615	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HER15_00620	COG0066	3-isopropylmalate dehydratase activity
HER15_00645	COG3279	Response regulator of the LytR AlgR family
HER15_00655	COG1028	Short-chain dehydrogenase reductase Sdr
HER15_00660	COG1942	4-Oxalocrotonate Tautomerase
HER15_00695	COG0010	Belongs to the arginase family
HER15_00700	COG1228	amidohydrolase
HER15_00720	COG0668	transmembrane transport
HER15_00735	COG1301	dicarboxylic acid transport
HER15_00740	COG2897	thiosulfate sulfurtransferase activity
HER15_00760	COG0210	DNA helicase
HER15_00770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HER15_00780	COG0583	DNA-binding transcription factor activity
HER15_00785	COG4221	oxidoreductase activity
HER15_00805	COG0776	regulation of translation
HER15_00810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HER15_00815	COG0514	ATP-dependent DNA helicase (RecQ)
HER15_00835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HER15_00840	COG0714	Associated with various cellular activities
HER15_00850	COG1733	regulation of RNA biosynthetic process
HER15_00855	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HER15_00860	COG1250	3-hydroxyacyl-CoA dehydrogenase
HER15_00870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HER15_00885	COG0813	purine-nucleoside phosphorylase activity
HER15_00915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HER15_00930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HER15_00935	COG0706	membrane insertase activity
HER15_00940	COG0504	CTP synthase activity
HER15_00945	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HER15_00955	COG0716	FMN binding
HER15_00960	COG1607	acyl-coa hydrolase
HER15_00980	COG3712	iron ion homeostasis
HER15_00985	COG1595	DNA-templated transcription, initiation
HER15_00995	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HER15_01000	COG1181	Belongs to the D-alanine--D-alanine ligase family
HER15_01010	COG0564	pseudouridine synthase activity
HER15_01015	COG0531	amino acid
HER15_01040	COG0165	Argininosuccinate lyase
HER15_01050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HER15_01060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HER15_01065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HER15_01070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HER15_01075	COG0137	argininosuccinate synthase activity
HER15_01090	COG0129	dihydroxy-acid dehydratase activity
HER15_01095	COG0028	Belongs to the TPP enzyme family
HER15_01105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HER15_01110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HER15_01115	COG3012	SEC-C Motif Domain Protein
HER15_01130	COG0784	Response regulator, receiver
HER15_01140	COG4251	negative regulation of phosphorylation
HER15_01150	COG3279	Response regulator of the LytR AlgR family
HER15_01195	COG0745	RESPONSE REGULATOR receiver
HER15_01235	COG1902	pentaerythritol trinitrate reductase activity
HER15_01240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HER15_01255	COG2207	Transcriptional regulator
HER15_01260	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HER15_01300	COG2373	Large extracellular alpha-helical protein
HER15_01305	COG4953	penicillin-binding protein 1C
HER15_01310	COG3263	regulation of cellular component size
HER15_01315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HER15_01320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HER15_01340	COG1253	flavin adenine dinucleotide binding
HER15_01375	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HER15_01380	COG0484	heat shock protein binding
HER15_01390	COG1049	propionate catabolic process, 2-methylcitrate cycle
HER15_01420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HER15_01450	COG0798	PFAM Bile acid sodium symporter
HER15_01475	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HER15_01480	COG1702	phosphate starvation-inducible protein PhoH
HER15_01490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HER15_01500	COG2010	Cytochrome c
HER15_01500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HER15_01505	COG0156	8-amino-7-oxononanoate synthase activity
HER15_01555	COG0671	phosphoesterase, PA-phosphatase related
HER15_01560	COG2259	Doxx family
HER15_01565	COG0671	phosphoesterase, PA-phosphatase related
HER15_01575	COG2207	Transcriptional regulator
HER15_01575	COG0662	Cupin 2, conserved barrel domain protein
HER15_01590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HER15_01685	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HER15_01690	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HER15_01695	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HER15_01705	COG4206	TonB-dependent receptor
HER15_01715	COG3011	Protein conserved in bacteria
HER15_01720	COG1136	(ABC) transporter
HER15_01725	COG1136	(ABC) transporter
HER15_01725	COG0577	efflux transmembrane transporter activity
HER15_01730	COG0577	efflux transmembrane transporter activity
HER15_01730	COG1136	(ABC) transporter
HER15_01740	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HER15_01745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HER15_01760	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HER15_01785	COG1028	Short-chain dehydrogenase reductase Sdr
HER15_01790	COG3956	TIGRFAM MazG family protein
HER15_01800	COG0242	peptide deformylase activity
HER15_01805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HER15_01820	COG0009	L-threonylcarbamoyladenylate synthase
HER15_01825	COG3119	arylsulfatase activity
HER15_01830	COG0617	tRNA 3'-terminal CCA addition
HER15_01830	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HER15_01830	COG0517	IMP dehydrogenase activity
HER15_01835	COG1132	(ABC) transporter
HER15_01840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HER15_01845	COG0463	Glycosyl transferase, family 2
HER15_01860	COG4974	Belongs to the 'phage' integrase family
HER15_01875	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HER15_01890	COG1183	phosphatidylcholine synthase activity
HER15_01905	COG0805	protein transport
HER15_01910	COG0517	IMP dehydrogenase activity
HER15_01910	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HER15_01915	COG0514	ATP-dependent DNA helicase (RecQ)
HER15_01935	COG0686	Belongs to the AlaDH PNT family
HER15_01940	COG0802	atpase or kinase
HER15_01945	COG2204	response regulator
HER15_01950	COG1078	dGTPase activity
HER15_01960	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HER15_01960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HER15_01965	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HER15_01970	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HER15_01980	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HER15_01985	COG1028	Short-chain dehydrogenase reductase Sdr
HER15_02040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HER15_02045	COG1690	Belongs to the RtcB family
HER15_02085	COG0300	oxidoreductase activity
HER15_02100	COG1741	Belongs to the pirin family
HER15_02140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HER15_02150	COG1061	Type III restriction enzyme res subunit
HER15_02160	COG0542	response to heat
HER15_02170	COG3047	cAMP biosynthetic process
HER15_02175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HER15_02185	COG0424	maF-like protein
HER15_02190	COG3958	Transketolase
HER15_02200	COG0545	Peptidyl-prolyl cis-trans isomerase
HER15_02205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HER15_02210	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HER15_02215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HER15_02235	COG0590	tRNA wobble adenosine to inosine editing
HER15_02270	COG2814	Major facilitator Superfamily
HER15_02280	COG1522	sequence-specific DNA binding
HER15_02300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HER15_02315	COG1739	Uncharacterized protein family UPF0029
HER15_02320	COG0697	spore germination
HER15_02325	COG1011	Hydrolase
HER15_02330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HER15_02330	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HER15_02345	COG2890	protein-(glutamine-N5) methyltransferase activity
HER15_02390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HER15_02405	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HER15_02410	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HER15_02415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HER15_02415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HER15_02430	COG2860	membrane
HER15_02455	COG0012	GTP binding
HER15_02460	COG4206	TonB-dependent receptor
HER15_02460	COG1629	transport
HER15_02465	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HER15_02475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HER15_02480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HER15_02490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HER15_02495	COG0322	excinuclease ABC activity
HER15_02500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HER15_02505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HER15_02520	COG1217	gtp-binding protein TYPA
HER15_02535	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HER15_02540	COG1196	nuclear chromosome segregation
HER15_02540	COG3264	Mechanosensitive ion channel
HER15_02545	COG0783	Belongs to the Dps family
HER15_02575	COG0438	transferase activity, transferring glycosyl groups
HER15_02580	COG3959	Transketolase, thiamine diphosphate binding domain
HER15_02610	COG2195	Cleaves the N-terminal amino acid of tripeptides
HER15_02625	COG0359	binds to the 23S rRNA
HER15_02630	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HER15_02635	COG0360	Binds together with S18 to 16S ribosomal RNA
HER15_02665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HER15_02665	COG0140	phosphoribosyl-ATP diphosphatase activity
HER15_02670	COG0107	imidazoleglycerol-phosphate synthase activity
HER15_02675	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HER15_02685	COG0131	Imidazoleglycerol-phosphate dehydratase
HER15_02690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HER15_02695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HER15_02700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HER15_02720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HER15_02730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HER15_02755	COG0076	glutamate decarboxylase activity
HER15_02765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HER15_02835	COG0527	aspartate kinase activity
HER15_02835	COG0460	homoserine dehydrogenase
HER15_02840	COG0083	homoserine kinase activity
HER15_02845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HER15_02860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HER15_02865	COG3275	phosphorelay sensor kinase activity
HER15_02870	COG3279	Response regulator of the LytR AlgR family
HER15_02885	COG0564	pseudouridine synthase activity
HER15_02890	COG2270	Major facilitator Superfamily
HER15_02915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HER15_02920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HER15_02950	COG2003	Belongs to the UPF0758 family
HER15_02955	COG3340	Belongs to the peptidase S51 family
HER15_03025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HER15_03040	COG0167	dihydroorotate dehydrogenase activity
HER15_03050	COG4733	cellulase activity
HER15_03050	COG5297	Belongs to the glycosyl hydrolase family 6
HER15_03070	COG1363	Peptidase, m42
HER15_03125	COG0488	(ABC) transporter
HER15_03135	COG0513	Belongs to the DEAD box helicase family
HER15_03150	COG1045	serine acetyltransferase
HER15_03155	COG0633	Ferredoxin
HER15_03160	COG0492	ferredoxin-NADP+ reductase activity
HER15_03165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HER15_03165	COG1648	precorrin-2 dehydrogenase activity
HER15_03170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HER15_03170	COG1648	precorrin-2 dehydrogenase activity
HER15_03175	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HER15_03180	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HER15_03190	COG0175	sulfate reduction
HER15_03195	COG0175	sulfate reduction
HER15_03205	COG1959	2 iron, 2 sulfur cluster binding
HER15_03215	COG0460	homoserine dehydrogenase
HER15_03215	COG0527	aspartate kinase activity
HER15_03225	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HER15_03230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HER15_03235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HER15_03240	COG0517	IMP dehydrogenase activity
HER15_03240	COG0516	GMP reductase activity
HER15_03260	COG0745	RESPONSE REGULATOR receiver
HER15_03265	COG2205	protein histidine kinase activity
HER15_03310	COG1595	DNA-templated transcription, initiation
HER15_03335	COG0525	valine-tRNA ligase activity
HER15_03345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HER15_03350	COG0436	Aminotransferase
HER15_03355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HER15_03375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HER15_03390	COG3876	Protein conserved in bacteria
HER15_03410	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HER15_03430	COG0714	Associated with various cellular activities
HER15_03475	COG0534	Mate efflux family protein
HER15_03490	COG1131	(ABC) transporter
HER15_03520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HER15_03520	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HER15_03530	COG0644	oxidoreductase
HER15_03540	COG0646	methionine synthase
HER15_03540	COG1410	methionine synthase
HER15_03545	COG0646	methionine synthase
HER15_03545	COG1410	methionine synthase
HER15_03550	COG2986	histidine ammonia-lyase
HER15_03555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HER15_03635	COG0433	COG0433 Predicted ATPase
HER15_03640	COG0602	queuosine metabolic process
HER15_03660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HER15_03670	COG0825	malonyl-CoA metabolic process
HER15_03685	COG0343	queuine tRNA-ribosyltransferase activity
HER15_03690	COG1187	pseudouridine synthase activity
HER15_03725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HER15_03730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HER15_03730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HER15_03745	COG1858	cytochrome C peroxidase
HER15_03770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HER15_03780	COG1012	belongs to the aldehyde dehydrogenase family
HER15_03785	COG2207	Transcriptional regulator
HER15_03795	COG0783	Belongs to the Dps family
HER15_03810	COG0659	secondary active sulfate transmembrane transporter activity
HER15_03815	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HER15_03820	COG0540	Belongs to the ATCase OTCase family
HER15_03835	COG1234	tRNA 3'-trailer cleavage
HER15_03855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HER15_03860	COG0326	Molecular chaperone. Has ATPase activity
HER15_03865	COG0564	pseudouridine synthase activity
HER15_03870	COG0336	Belongs to the RNA methyltransferase TrmD family
HER15_03875	COG0335	large ribosomal subunit rRNA binding
HER15_03930	COG1090	epimerase
HER15_03935	COG0454	-acetyltransferase
HER15_03940	COG0508	dehydrogenase complex catalyzes the overall conversion of
HER15_03945	COG0408	coproporphyrinogen oxidase activity
HER15_03960	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HER15_03965	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HER15_03975	COG0113	porphobilinogen synthase activity
HER15_03995	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HER15_04010	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HER15_04015	COG1981	membrane
HER15_04025	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HER15_04030	COG2195	Cleaves the N-terminal amino acid of tripeptides
HER15_04035	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HER15_04040	COG0405	Gamma-glutamyltransferase
HER15_04045	COG4946	Tricorn protease homolog
HER15_04045	COG0793	Belongs to the peptidase S41A family
HER15_04070	COG2326	polyphosphate kinase activity
HER15_04080	COG0592	DNA-directed DNA polymerase activity
HER15_04085	COG1192	Involved in chromosome partitioning
HER15_04090	COG1475	DNA binding
HER15_04100	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HER15_04105	COG0681	Belongs to the peptidase S26 family
HER15_04140	COG2207	Transcriptional regulator
HER15_04160	COG0456	acetyltransferase
HER15_04165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HER15_04190	COG1472	Belongs to the glycosyl hydrolase 3 family
HER15_04205	COG2326	polyphosphate kinase activity
HER15_04210	COG0655	NAD(P)H dehydrogenase (quinone) activity
HER15_04225	COG3279	Response regulator of the LytR AlgR family
HER15_04250	COG3275	phosphorelay sensor kinase activity
HER15_04275	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HER15_04280	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HER15_04285	COG1393	Belongs to the ArsC family
HER15_04295	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HER15_04340	COG1418	mRNA catabolic process
HER15_04375	COG2076	Multidrug Resistance protein
HER15_04385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HER15_04390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HER15_04395	COG1120	ATPase activity
HER15_04400	COG2234	aminopeptidase activity
HER15_04405	COG0076	glutamate decarboxylase activity
HER15_04415	COG2813	Specifically methylates the guanine in position
HER15_04420	COG0069	glutamate synthase activity
HER15_04425	COG0254	rRNA binding
HER15_04445	COG1028	Short-chain dehydrogenase reductase Sdr
HER15_04450	COG3091	SprT-like family
HER15_04465	COG1663	tetraacyldisaccharide 4'-kinase activity
HER15_04470	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HER15_04485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HER15_04495	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HER15_04495	COG3608	succinylglutamate desuccinylase aspartoacylase
HER15_04530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HER15_04570	COG0045	succinate-CoA ligase (ADP-forming) activity
HER15_04580	COG1136	(ABC) transporter
HER15_04615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HER15_04640	COG0154	amidase activity
HER15_04645	COG1733	regulation of RNA biosynthetic process
HER15_04655	COG0552	protein localization to endoplasmic reticulum
HER15_04665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HER15_04670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HER15_04675	COG1546	Belongs to the CinA family
HER15_04675	COG1058	Belongs to the CinA family
HER15_04680	COG0179	Fumarylacetoacetate (FAA) hydrolase
HER15_04695	COG2996	Protein conserved in bacteria
HER15_04700	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HER15_04705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HER15_04710	COG0300	oxidoreductase activity
HER15_04730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HER15_04750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HER15_04755	COG3119	arylsulfatase activity
HER15_04770	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HER15_04775	COG0508	dehydrogenase complex catalyzes the overall conversion of
HER15_04830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HER15_04840	COG0671	phosphoesterase, PA-phosphatase related
HER15_04845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HER15_04850	COG0545	Peptidyl-prolyl cis-trans isomerase
HER15_04860	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HER15_04870	COG0105	UTP biosynthetic process
HER15_04910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HER15_04920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HER15_04930	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HER15_04995	COG4585	Histidine kinase
HER15_05015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HER15_05020	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HER15_05025	COG4166	transmembrane transport
HER15_05035	COG2329	Antibiotic biosynthesis monooxygenase
HER15_05045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HER15_05080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HER15_05090	COG1629	transport
HER15_05095	COG0302	gtp cyclohydrolase
HER15_05100	COG0124	histidyl-tRNA synthetase
HER15_05105	COG1295	ribonuclease BN
HER15_05120	COG0339	signal peptide processing
HER15_05135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HER15_05140	COG3128	pkhd-type hydroxylase
HER15_05245	COG4974	Belongs to the 'phage' integrase family
HER15_05300	COG1607	acyl-coa hydrolase
HER15_05325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HER15_05330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HER15_05380	COG1785	Belongs to the alkaline phosphatase family
HER15_05380	COG1785	Belongs to the alkaline phosphatase family
HER15_05385	COG0702	epimerase
HER15_05390	COG4771	TonB-dependent receptor
HER15_05395	COG0745	RESPONSE REGULATOR receiver
HER15_05395	COG2205	protein histidine kinase activity
HER15_05395	COG3292	Two component regulator propeller
HER15_05455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HER15_05460	COG0116	Belongs to the methyltransferase superfamily
HER15_05475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HER15_05475	COG0662	Cupin 2, conserved barrel domain protein
HER15_05490	COG0110	maltose O-acetyltransferase activity
HER15_05510	COG1846	Transcriptional regulator
HER15_05515	COG1764	response to oxidative stress
HER15_05545	COG0259	pyridoxamine-phosphate oxidase activity
HER15_05595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HER15_05625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HER15_05670	COG0589	response to stress
HER15_05690	COG0348	domain, Protein
HER15_05695	COG2010	Cytochrome c
HER15_05705	COG3278	Belongs to the heme-copper respiratory oxidase family
HER15_05715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HER15_05720	COG0813	purine-nucleoside phosphorylase activity
HER15_05725	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HER15_05745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HER15_05750	COG0085	RNA polymerase activity
HER15_05755	COG0222	ribosome binding
HER15_05760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HER15_05765	COG0081	regulation of translation
HER15_05770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HER15_05790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HER15_05825	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HER15_05830	COG1960	acyl-CoA dehydrogenase activity
HER15_05840	COG1115	amino acid carrier protein
HER15_05850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HER15_05925	COG1611	Belongs to the LOG family
HER15_05950	COG0778	Nitroreductase
HER15_05955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HER15_05970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HER15_05975	COG1280	lysine exporter protein (LysE YggA)
HER15_05980	COG0583	DNA-binding transcription factor activity
HER15_05995	COG0450	alkyl hydroperoxide reductase
HER15_06000	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HER15_06025	COG2204	response regulator
HER15_06030	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HER15_06030	COG3264	Mechanosensitive ion channel
HER15_06035	COG1668	transmembrane transport
HER15_06040	COG4152	abc transporter atp-binding protein
HER15_06050	COG1250	3-hydroxyacyl-CoA dehydrogenase
HER15_06050	COG1024	Enoyl-CoA hydratase
HER15_06055	COG0183	Belongs to the thiolase family
HER15_06065	COG1960	acyl-CoA dehydrogenase activity
HER15_06130	COG0492	ferredoxin-NADP+ reductase activity
HER15_06195	COG2207	Transcriptional regulator
HER15_06275	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HER15_06285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HER15_06290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HER15_06300	COG2204	response regulator
HER15_06305	COG4191	Histidine kinase
HER15_06325	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HER15_06340	COG2197	response regulator
HER15_06360	COG0101	tRNA pseudouridine synthase activity
HER15_06365	COG1132	(ABC) transporter
HER15_06375	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HER15_06380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HER15_06395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HER15_06425	COG0572	uridine kinase
HER15_06435	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HER15_06435	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HER15_06445	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HER15_06445	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HER15_06455	COG0688	phosphatidylethanolamine metabolic process
HER15_06460	COG1333	cytochrome c biogenesis protein
HER15_06460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HER15_06475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HER15_06480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HER15_06490	COG0295	cytidine deaminase activity
HER15_06500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HER15_06500	COG0519	Catalyzes the synthesis of GMP from XMP
HER15_06505	COG0860	N-Acetylmuramoyl-L-alanine amidase
HER15_06505	COG1388	LysM domain
HER15_06520	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HER15_06525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HER15_06560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HER15_06610	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HER15_06625	COG0285	dihydrofolate synthase activity
HER15_06635	COG0848	biopolymer transport protein
HER15_06640	COG0811	peptide transport
HER15_06650	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HER15_06655	COG1960	acyl-CoA dehydrogenase activity
HER15_06660	COG0101	tRNA pseudouridine synthase activity
HER15_06665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HER15_06670	COG0857	belongs to the CobB CobQ family
HER15_06670	COG0280	phosphate acetyltransferase
HER15_06730	COG4251	negative regulation of phosphorylation
HER15_06735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HER15_06740	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HER15_06745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HER15_06750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HER15_06765	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HER15_06770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HER15_06775	COG0563	adenylate kinase activity
HER15_06780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HER15_06800	COG4206	TonB-dependent receptor
HER15_06800	COG1629	transport
HER15_06815	COG3279	Response regulator of the LytR AlgR family
HER15_06820	COG0791	NLP P60 protein
HER15_06825	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HER15_06835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HER15_06890	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HER15_06910	COG0658	competence protein
HER15_06910	COG2333	competence protein COMEC
HER15_06915	COG4232	protein-disulfide reductase activity
HER15_06925	COG3104	oligopeptide transport
HER15_06930	COG0823	Involved in the tonB-independent uptake of proteins
HER15_06930	COG1506	peptidase
HER15_06945	COG2081	HI0933 family
HER15_06985	COG1187	pseudouridine synthase activity
HER15_07145	COG0542	response to heat
HER15_07175	COG0138	bifunctional purine biosynthesis protein purh
HER15_07180	COG1077	Cell shape determining protein MreB Mrl
HER15_07195	COG0768	penicillin binding
HER15_07200	COG0772	Belongs to the SEDS family
HER15_07205	COG0268	Binds directly to 16S ribosomal RNA
HER15_07220	COG0442	prolyl-tRNA aminoacylation
HER15_07235	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HER15_07240	COG2226	methyltransferase
HER15_07265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HER15_07270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HER15_07280	COG0517	IMP dehydrogenase activity
HER15_07295	COG1271	oxidase subunit
HER15_07300	COG1294	oxidase, subunit
HER15_07330	COG3279	Response regulator of the LytR AlgR family
HER15_07335	COG3275	phosphorelay sensor kinase activity
HER15_07365	COG1629	transport
HER15_07365	COG4206	TonB-dependent receptor
HER15_07380	COG1610	YqeY-like protein
HER15_07385	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HER15_07400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HER15_07405	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HER15_07415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HER15_07420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HER15_07425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HER15_07430	COG0768	penicillin binding
HER15_07440	COG0275	rRNA processing
HER15_07445	COG2001	Belongs to the MraZ family
HER15_07455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HER15_07460	COG0564	pseudouridine synthase activity
HER15_07470	COG1012	belongs to the aldehyde dehydrogenase family
HER15_07510	COG5002	protein histidine kinase activity
HER15_07510	COG2198	Histidine kinase
HER15_07510	COG0784	Response regulator, receiver
HER15_07530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HER15_07540	COG0668	transmembrane transport
HER15_07545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HER15_07575	COG1309	transcriptional regulator
HER15_07615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HER15_07635	COG0612	Peptidase, M16
HER15_07650	COG4771	TonB-dependent receptor
HER15_07690	COG1522	sequence-specific DNA binding
HER15_07695	COG0626	cystathionine gamma-synthase activity
HER15_07700	COG1757	Na H antiporter
HER15_07720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HER15_07735	COG2824	Alkylphosphonate utilization operon protein PhnA
HER15_07740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HER15_07745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HER15_07750	COG0228	four-way junction DNA binding
HER15_07755	COG1278	Cold shock
HER15_07825	COG3501	Rhs element vgr protein
HER15_07870	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HER15_07880	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HER15_07890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HER15_07900	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HER15_07905	COG2086	electron transfer activity
HER15_07910	COG0022	dehydrogenase e1 component
HER15_07910	COG0508	dehydrogenase complex catalyzes the overall conversion of
HER15_07915	COG4771	TonB-dependent receptor
HER15_07920	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HER15_07925	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HER15_07930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HER15_07940	COG2267	carboxylic ester hydrolase activity
HER15_07945	COG0037	tRNA processing
HER15_07950	COG0785	Cytochrome C biogenesis protein
HER15_08015	COG4974	Belongs to the 'phage' integrase family
HER15_08050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HER15_08060	COG1528	Iron-storage protein
HER15_08065	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HER15_08080	COG3201	nicotinamide mononucleotide transporter
HER15_08130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HER15_08135	COG0439	Biotin carboxylase
HER15_08140	COG4770	biotin carboxylase activity
HER15_08155	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HER15_08160	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HER15_08165	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HER15_08170	COG1805	sodium ion transport
HER15_08180	COG1858	cytochrome C peroxidase
HER15_08205	COG2967	ApaG domain
HER15_08235	COG1012	belongs to the aldehyde dehydrogenase family
HER15_08240	COG2066	Belongs to the glutaminase family
HER15_08255	COG0513	Belongs to the DEAD box helicase family
HER15_08275	COG0357	Ribosomal RNA small subunit methyltransferase G
HER15_08280	COG3239	Fatty acid desaturase
HER15_08285	COG0436	Aminotransferase
HER15_08295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HER15_08295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HER15_08305	COG2255	four-way junction helicase activity
HER15_08310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HER15_08340	COG0437	4 iron, 4 sulfur cluster binding
HER15_08365	COG2166	iron-sulfur cluster assembly
HER15_08370	COG2151	metal-sulfur cluster biosynthetic enzyme
HER15_08390	COG1253	flavin adenine dinucleotide binding
HER15_08410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HER15_08415	COG1573	uracil-dna glycosylase
HER15_08425	COG0513	Belongs to the DEAD box helicase family
HER15_08440	COG0084	hydrolase, TatD family'
HER15_08450	COG0590	tRNA wobble adenosine to inosine editing
HER15_08460	COG4771	TonB-dependent receptor
HER15_08470	COG4771	TonB-dependent receptor
HER15_08475	COG0714	Associated with various cellular activities
HER15_08490	COG2304	oxidoreductase activity
HER15_08500	COG2304	oxidoreductase activity
HER15_08525	COG0659	secondary active sulfate transmembrane transporter activity
HER15_08535	COG0288	reversible hydration of carbon dioxide
HER15_08550	COG1028	Short-chain dehydrogenase reductase Sdr
HER15_08560	COG0792	nuclease activity
HER15_08570	COG1619	proteins homologs of microcin C7 resistance protein MccF
HER15_08575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HER15_08575	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HER15_08585	COG2183	response to ionizing radiation
HER15_08600	COG0629	single-stranded DNA binding
HER15_08615	COG0516	GMP reductase activity
HER15_08625	COG0469	pyruvate kinase activity
HER15_08635	COG0571	ribonuclease III activity
HER15_08640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HER15_08645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HER15_08650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HER15_08655	COG0328	RNA-DNA hybrid ribonuclease activity
HER15_08655	COG3341	Caulimovirus viroplasmin
HER15_08675	COG0668	transmembrane transport
HER15_08680	COG1214	PFAM Peptidase M22, glycoprotease
HER15_08695	COG2322	membrane
HER15_08700	COG1999	signal sequence binding
HER15_08715	COG1845	cytochrome c oxidase, subunit III
HER15_08720	COG1845	cytochrome c oxidase, subunit III
HER15_08725	COG0109	protoheme IX farnesyltransferase activity
HER15_08765	COG1054	Belongs to the UPF0176 family
HER15_08780	COG2226	methyltransferase
HER15_08785	COG1619	proteins homologs of microcin C7 resistance protein MccF
HER15_08790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HER15_08800	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HER15_08810	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HER15_08815	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HER15_08820	COG0297	glycogen (starch) synthase activity
HER15_08830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HER15_08850	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HER15_08860	COG1115	amino acid carrier protein
HER15_08870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HER15_08880	COG0584	glycerophosphoryl diester phosphodiesterase
HER15_08885	COG1288	antiporter activity
HER15_08900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HER15_08915	COG1999	signal sequence binding
HER15_08930	COG0460	homoserine dehydrogenase
HER15_08930	COG0527	aspartate kinase activity
HER15_08940	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HER15_08955	COG1309	transcriptional regulator
HER15_08960	COG0626	cystathionine gamma-synthase activity
HER15_09010	COG1408	metallophosphoesterase
HER15_09015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HER15_09015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HER15_09020	COG2378	regulation of single-species biofilm formation
HER15_09040	COG1040	competence protein
HER15_09060	COG0423	glycine-tRNA ligase activity
HER15_09075	COG1629	transport
HER15_09080	COG0196	riboflavin kinase activity
HER15_09090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HER15_09115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HER15_09120	COG2239	Acts as a magnesium transporter
HER15_09150	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HER15_09155	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HER15_09170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HER15_09175	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HER15_09180	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HER15_09185	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HER15_09190	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HER15_09195	COG0356	it plays a direct role in the translocation of protons across the membrane
HER15_09235	COG1388	LysM domain
HER15_09235	COG4932	domain protein
HER15_09240	COG0708	Exodeoxyribonuclease III
HER15_09250	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HER15_09255	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HER15_09265	COG1774	PSP1 C-terminal conserved region
HER15_09270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HER15_09290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HER15_09360	COG0189	ligase activity
HER15_09370	COG0513	Belongs to the DEAD box helicase family
HER15_09380	COG0006	proline dipeptidase activity
HER15_09460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HER15_09475	COG1053	succinate dehydrogenase
HER15_09480	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HER15_09495	COG4221	oxidoreductase activity
HER15_09520	COG3842	ATPase activity
HER15_09525	COG0189	ligase activity
HER15_09535	COG3590	peptidase
HER15_09540	COG1505	serine-type exopeptidase activity
HER15_09555	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HER15_09555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HER15_09560	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HER15_09570	COG2095	MarC family integral membrane protein
HER15_09580	COG2356	endonuclease I
HER15_09585	COG3279	Response regulator of the LytR AlgR family
HER15_09605	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HER15_09640	COG1595	DNA-templated transcription, initiation
HER15_09650	COG1446	asparaginase
HER15_09655	COG1012	belongs to the aldehyde dehydrogenase family
HER15_09670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HER15_09675	COG0756	dUTP diphosphatase activity
HER15_09680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HER15_09685	COG1187	pseudouridine synthase activity
HER15_09695	COG2153	protein acetylation
HER15_09700	COG0698	ribose 5-phosphate isomerase
HER15_09710	COG1597	lipid kinase activity
HER15_09715	COG0557	exoribonuclease II activity
HER15_09730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HER15_09735	COG0393	Putative heavy-metal-binding
HER15_09750	COG0500	methyltransferase
HER15_09755	COG0445	tRNA wobble uridine modification
HER15_09760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HER15_09780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HER15_09825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HER15_09830	COG2827	Endonuclease containing a URI domain
HER15_09850	COG0758	DNA mediated transformation
HER15_09850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HER15_09865	COG0628	permease
HER15_09885	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HER15_09905	COG4733	cellulase activity
HER15_09905	COG5297	Belongs to the glycosyl hydrolase family 6
HER15_09910	COG0488	(ABC) transporter
HER15_09925	COG0745	RESPONSE REGULATOR receiver
HER15_09930	COG5002	protein histidine kinase activity
HER15_09935	COG0151	Belongs to the GarS family
HER15_09945	COG0793	Belongs to the peptidase S41A family
HER15_09950	COG0594	ribonuclease P activity
HER15_09965	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HER15_09975	COG4585	Histidine kinase
HER15_09980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HER15_09985	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HER15_09990	COG0302	gtp cyclohydrolase
HER15_10010	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HER15_10020	COG3708	Transcriptional regulator
HER15_10020	COG2207	Transcriptional regulator
HER15_10030	COG0720	synthase
HER15_10035	COG0193	aminoacyl-tRNA hydrolase activity
HER15_10040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HER15_10045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HER15_10055	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HER15_10060	COG0315	cyclic pyranopterin monophosphate synthase activity
HER15_10060	COG0746	molybdenum cofactor guanylyltransferase activity
HER15_10075	COG0303	'Molybdopterin
HER15_10080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HER15_10085	COG0322	excinuclease ABC activity
HER15_10090	COG1752	Esterase of the alpha-beta hydrolase superfamily
HER15_10095	COG1530	ribonuclease E activity
HER15_10100	COG0776	regulation of translation
HER15_10120	COG4771	TonB-dependent receptor
HER15_10125	COG1194	a g-specific adenine glycosylase
HER15_10130	COG0629	single-stranded DNA binding
HER15_10165	COG0612	Peptidase, M16
HER15_10170	COG0612	Peptidase, M16
HER15_10175	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HER15_10180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HER15_10185	COG3279	Response regulator of the LytR AlgR family
HER15_10190	COG0745	RESPONSE REGULATOR receiver
HER15_10190	COG2972	Histidine kinase
HER15_10195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HER15_10205	COG0826	peptidase U32
HER15_10215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HER15_10220	COG1418	mRNA catabolic process
HER15_10225	COG1024	Enoyl-CoA hydratase
HER15_10230	COG5000	phosphorelay sensor kinase activity
HER15_10240	COG0470	DNA polymerase III
HER15_10265	COG1114	Component of the transport system for branched-chain amino acids
HER15_10275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HER15_10290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HER15_10305	COG0489	protein tyrosine kinase activity
HER15_10315	COG0492	ferredoxin-NADP+ reductase activity
HER15_10325	COG0633	Ferredoxin
HER15_10330	COG0076	glutamate decarboxylase activity
HER15_10335	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HER15_10380	COG1024	Enoyl-CoA hydratase
HER15_10405	COG1629	transport
HER15_10405	COG4206	TonB-dependent receptor
HER15_10420	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HER15_10425	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HER15_10445	COG0166	Belongs to the GPI family
HER15_10450	COG1629	transport
HER15_10450	COG4206	TonB-dependent receptor
HER15_10490	COG0314	molybdopterin synthase activity
HER15_10495	COG0126	phosphoglycerate kinase activity
HER15_10500	COG0667	Aldo Keto reductase
HER15_10515	COG0180	Tryptophanyl-tRNA synthetase
HER15_10525	COG1272	protein, Hemolysin III
HER15_10535	COG2954	triphosphatase activity
HER15_10540	COG1381	Involved in DNA repair and RecF pathway recombination
HER15_10550	COG2814	Major facilitator Superfamily
HER15_10570	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HER15_10575	COG0840	transmembrane signaling receptor activity
HER15_10580	COG0840	transmembrane signaling receptor activity
HER15_10590	COG0632	four-way junction helicase activity
HER15_10600	COG0509	glycine decarboxylation via glycine cleavage system
HER15_10630	COG1215	transferase activity, transferring glycosyl groups
HER15_10650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HER15_10670	COG4717	serine-type aminopeptidase activity
HER15_10695	COG4771	TonB-dependent receptor
HER15_10715	COG0463	Glycosyl transferase, family 2
HER15_10725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HER15_10740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HER15_10755	COG1858	cytochrome C peroxidase
HER15_10780	COG0495	leucyl-tRNA aminoacylation
HER15_10805	COG1946	Acyl-CoA thioesterase
HER15_10850	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HER15_10850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HER15_10865	COG1970	mechanosensitive ion channel activity
HER15_10870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HER15_10875	COG1435	thymidine kinase activity
HER15_10895	COG0779	Required for maturation of 30S ribosomal subunits
HER15_10900	COG0195	Participates in both transcription termination and antitermination
HER15_10900	COG2251	uridine kinase activity
HER15_10905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HER15_10930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HER15_10935	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HER15_10950	COG1595	DNA-templated transcription, initiation
HER15_10980	COG4771	TonB-dependent receptor
HER15_11010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HER15_11020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HER15_11065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HER15_11080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HER15_11090	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HER15_11100	COG0156	8-amino-7-oxononanoate synthase activity
HER15_11135	COG3209	COG3209 Rhs family protein
HER15_11185	COG0567	Dehydrogenase, E1 component
HER15_11190	COG0508	dehydrogenase complex catalyzes the overall conversion of
HER15_11205	COG2819	hydrolase of the alpha beta superfamily
HER15_11220	COG0719	Fe-S assembly protein
HER15_11225	COG0396	ATPase activity
HER15_11230	COG0719	Fe-S assembly protein
HER15_11240	COG1858	cytochrome C peroxidase
HER15_11260	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HER15_11265	COG1652	LysM domain
HER15_11275	COG1561	YicC-like family, N-terminal region
HER15_11280	COG0194	GDP metabolic process
HER15_11285	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HER15_11290	COG4942	peptidase
HER15_11300	COG2258	MOSC domain
HER15_11315	COG0793	Belongs to the peptidase S41A family
HER15_11330	COG1522	sequence-specific DNA binding
HER15_11345	COG3655	Transcriptional regulator
HER15_11350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HER15_11365	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HER15_11370	COG2885	chlorophyll binding
HER15_11375	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HER15_11395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HER15_11415	COG2391	methyltransferase activity
HER15_11420	COG1519	Transferase
HER15_11420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HER15_11425	COG0439	Biotin carboxylase
HER15_11430	COG0511	ligase activity, forming carbon-carbon bonds
HER15_11435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HER15_11440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HER15_11450	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HER15_11500	COG1309	transcriptional regulator
HER15_11530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HER15_11545	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HER15_11550	COG1968	undecaprenyl-diphosphatase activity
HER15_11560	COG2177	Part of the ABC transporter FtsEX involved in
HER15_11565	COG0346	lactoylglutathione lyase activity
HER15_11590	COG4585	Histidine kinase
HER15_11600	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HER15_11605	COG4591	ABC-type transport system involved in lipoprotein release permease component
HER15_11630	COG0481	GTPase activity
HER15_11645	COG0252	asparaginase activity
HER15_11650	COG0811	peptide transport
HER15_11685	COG0017	Asparaginyl-tRNA synthetase
HER15_11695	COG0233	cytoplasmic translational termination
HER15_11700	COG0528	UMP kinase activity
HER15_11705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HER15_11710	COG0052	Belongs to the universal ribosomal protein uS2 family
HER15_11715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HER15_11720	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HER15_11735	COG1477	protein flavinylation
HER15_11740	COG2226	methyltransferase
HER15_11755	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HER15_11770	COG0501	Belongs to the peptidase M48B family
HER15_11795	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HER15_11845	COG0702	epimerase
HER15_11855	COG0415	Belongs to the DNA photolyase family
HER15_11860	COG3046	protein related to deoxyribodipyrimidine photolyase
HER15_11865	COG0415	Belongs to the DNA photolyase family
HER15_11885	COG0302	gtp cyclohydrolase
HER15_11895	COG1028	Short-chain dehydrogenase reductase Sdr
HER15_11905	COG0386	Belongs to the glutathione peroxidase family
HER15_11920	COG0415	Belongs to the DNA photolyase family
HER15_11925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HER15_11995	COG2972	Histidine kinase
HER15_11995	COG0745	RESPONSE REGULATOR receiver
HER15_12000	COG3279	Response regulator of the LytR AlgR family
HER15_12025	COG2363	Small membrane protein
HER15_12040	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HER15_12085	COG1160	GTP binding
HER15_12095	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HER15_12125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HER15_12130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HER15_12140	COG1473	amidohydrolase
HER15_12150	COG3457	Alanine racemase
HER15_12160	COG2423	ornithine cyclodeaminase activity
HER15_12170	COG0006	proline dipeptidase activity
HER15_12175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HER15_12180	COG3938	Belongs to the proline racemase family
HER15_12190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HER15_12195	COG4977	sequence-specific DNA binding
HER15_12205	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HER15_12225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HER15_12235	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HER15_12245	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HER15_12250	COG0596	Alpha beta hydrolase
HER15_12275	COG2249	NAD(P)H dehydrogenase (quinone) activity
HER15_12285	COG1950	PFAM Membrane protein of
HER15_12290	COG0544	peptidyl-prolyl cis-trans isomerase activity
HER15_12300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HER15_12310	COG0358	DNA primase activity
HER15_12315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HER15_12330	COG1428	Deoxynucleoside kinase
HER15_12335	COG1185	polyribonucleotide nucleotidyltransferase activity
HER15_12340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HER15_12345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HER15_12350	COG0191	fructose-bisphosphate aldolase activity
HER15_12360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HER15_12365	COG0641	radical SAM
HER15_12375	COG1428	Deoxynucleoside kinase
HER15_12385	COG0321	lipoyl(octanoyl) transferase activity
HER15_12395	COG1490	D-aminoacyl-tRNA deacylase activity
HER15_12400	COG1162	GTPase activity
HER15_12405	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HER15_12415	COG0436	Aminotransferase
HER15_12440	COG3118	belongs to the thioredoxin family
HER15_12445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HER15_12455	COG0616	signal peptide processing
HER15_12465	COG0519	Catalyzes the synthesis of GMP from XMP
HER15_12480	COG4221	oxidoreductase activity
HER15_12495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HER15_12510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HER15_12510	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HER15_12515	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HER15_12520	COG1607	acyl-coa hydrolase
HER15_12525	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HER15_12535	COG1252	NADH dehydrogenase
HER15_12550	COG2363	Small membrane protein
HER15_12555	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HER15_12560	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HER15_12565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HER15_12570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HER15_12600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HER15_12605	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HER15_12610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HER15_12630	COG0459	protein refolding
HER15_12635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HER15_12660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HER15_12675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HER15_12705	COG0488	(ABC) transporter
HER15_12735	COG0791	NLP P60 protein
HER15_12735	COG1388	LysM domain
HER15_12735	COG3103	Sh3 type 3 domain protein
HER15_12750	COG3275	phosphorelay sensor kinase activity
HER15_12755	COG3279	Response regulator of the LytR AlgR family
HER15_12760	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HER15_12780	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HER15_12780	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HER15_12790	COG0542	response to heat
HER15_12805	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HER15_12830	COG1253	flavin adenine dinucleotide binding
HER15_12845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HER15_12880	COG0339	signal peptide processing
HER15_12885	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HER15_12890	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HER15_12900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HER15_12915	COG3852	Histidine kinase
HER15_12940	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HER15_12945	COG2031	fatty acid transporter
HER15_12950	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HER15_12995	COG1032	radical SAM domain protein
HER15_13005	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HER15_13025	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HER15_13045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HER15_13055	COG1595	DNA-templated transcription, initiation
HER15_13065	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HER15_13095	COG2884	Cell division ATP-binding protein ftsE
HER15_13100	COG0039	L-malate dehydrogenase activity
HER15_13115	COG0187	DNA topoisomerase II activity
HER15_13125	COG0367	asparagine synthase
HER15_13135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HER15_13140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HER15_13140	COG0512	Glutamine amidotransferase of anthranilate synthase
HER15_13145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HER15_13150	COG0134	indole-3-glycerol-phosphate synthase activity
HER15_13155	COG0135	phosphoribosylanthranilate isomerase activity
HER15_13160	COG0133	tryptophan synthase activity
HER15_13165	COG0159	tryptophan synthase activity
HER15_13170	COG0793	Belongs to the peptidase S41A family
HER15_13170	COG4946	Tricorn protease homolog
HER15_13180	COG0514	ATP-dependent DNA helicase (RecQ)
HER15_13240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HER15_13240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HER15_13240	COG1703	isobutyryl-CoA mutase activity
HER15_13250	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HER15_13275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HER15_13280	COG3279	Response regulator of the LytR AlgR family
HER15_13285	COG1629	transport
HER15_13295	COG1629	transport
HER15_13305	COG0284	orotidine-5'-phosphate decarboxylase activity
HER15_13310	COG0601	transmembrane transport
HER15_13320	COG0149	triose-phosphate isomerase activity
HER15_13325	COG2264	protein methyltransferase activity
HER15_13330	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HER15_13370	COG0010	Belongs to the arginase family
HER15_13375	COG1166	arginine decarboxylase activity
HER15_13395	COG0598	Magnesium transport protein CorA
HER15_13405	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HER15_13425	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HER15_13430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HER15_13465	COG0174	glutamine synthetase
HER15_13505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HER15_13515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HER15_13520	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HER15_13525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HER15_13555	COG2249	NAD(P)H dehydrogenase (quinone) activity
HER15_13565	COG0778	Nitroreductase
HER15_13570	COG1733	regulation of RNA biosynthetic process
HER15_13575	COG2249	NAD(P)H dehydrogenase (quinone) activity
HER15_13580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HER15_13600	COG3591	Belongs to the peptidase S1B family
HER15_13615	COG3530	Putative quorum-sensing-regulated virulence factor
HER15_13625	COG4452	Inner membrane protein CreD
HER15_13655	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HER15_13665	COG1404	Belongs to the peptidase S8 family
HER15_13695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HER15_13725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HER15_13735	COG2003	Belongs to the UPF0758 family
HER15_13765	COG2855	membrane
HER15_13770	COG0583	DNA-binding transcription factor activity
HER15_13775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HER15_13785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HER15_13795	COG4206	TonB-dependent receptor
HER15_13795	COG1629	transport
HER15_13805	COG1629	transport
HER15_13805	COG4206	TonB-dependent receptor
HER15_13810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HER15_13815	COG0049	tRNA binding
HER15_13820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HER15_13825	COG0051	transcription antitermination factor activity, RNA binding
HER15_13830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HER15_13835	COG0088	Forms part of the polypeptide exit tunnel
HER15_13840	COG0089	rRNA binding
HER15_13845	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HER15_13850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HER15_13855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HER15_13860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HER15_13865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HER15_13870	COG0255	Belongs to the universal ribosomal protein uL29 family
HER15_13875	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HER15_13880	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HER15_13885	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HER15_13890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HER15_13895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HER15_13900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HER15_13905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HER15_13910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HER15_13915	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HER15_13920	COG1841	ribosomal large subunit assembly
HER15_13925	COG0200	Binds to the 23S rRNA
HER15_13935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HER15_13940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HER15_13945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HER15_13950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HER15_13955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HER15_13960	COG0202	RNA polymerase activity
HER15_13965	COG0203	ribosomal protein L17
HER15_13970	COG0505	Belongs to the CarA family
HER15_13975	COG0148	phosphopyruvate hydratase activity
HER15_14000	COG0010	Belongs to the arginase family
HER15_14005	COG2104	thiamine diphosphate biosynthetic process
HER15_14025	COG0352	thiamine-phosphate diphosphorylase activity
HER15_14030	COG2022	thiamine diphosphate biosynthetic process
HER15_14035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HER15_14090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HER15_14100	COG1595	DNA-templated transcription, initiation
HER15_14115	COG0215	cysteine-tRNA ligase activity
HER15_14120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HER15_14125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HER15_14135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HER15_14160	COG2217	Heavy metal translocating P-type atpase
HER15_14165	COG2207	Transcriptional regulator
HER15_14170	COG0542	response to heat
HER15_14185	COG0791	NLP P60 protein
HER15_14190	COG0183	Belongs to the thiolase family
HER15_14310	COG0697	spore germination
HER15_14315	COG1917	Cupin 2, conserved barrel domain protein
HER15_14315	COG4977	sequence-specific DNA binding
HER15_14320	COG3878	Protein conserved in bacteria
HER15_14330	COG0488	(ABC) transporter
HER15_14335	COG0653	protein targeting
HER15_14350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HER15_14350	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HER15_14360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HER15_14380	COG3844	kynureninase activity
HER15_14390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HER15_14395	COG1396	sequence-specific DNA binding
HER15_14405	COG1842	Phage shock protein A
HER15_14420	COG2255	four-way junction helicase activity
HER15_14445	COG1028	Short-chain dehydrogenase reductase Sdr
HER15_14450	COG0662	Cupin 2, conserved barrel domain protein
HER15_14475	COG2274	protein secretion by the type I secretion system
HER15_14485	COG3104	oligopeptide transport
HER15_14500	COG4589	Belongs to the CDS family
HER15_14510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HER15_14515	COG0799	negative regulation of ribosome biogenesis
HER15_14530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HER15_14535	COG0494	nUDIX hydrolase
HER15_14540	COG0443	Heat shock 70 kDa protein
HER15_14555	COG2972	Histidine kinase
HER15_14555	COG0745	RESPONSE REGULATOR receiver
HER15_14560	COG3279	Response regulator of the LytR AlgR family
HER15_14580	COG1252	NADH dehydrogenase
HER15_14610	COG4656	Part of a membrane complex involved in electron transport
HER15_14635	COG2249	NAD(P)H dehydrogenase (quinone) activity
HER15_14650	COG1073	alpha beta
HER15_14685	COG2814	Major facilitator Superfamily
HER15_14690	COG0656	L-ascorbic acid biosynthetic process
HER15_14700	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HER15_14700	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HER15_14715	COG1674	ftsk spoiiie
HER15_14730	COG0534	Mate efflux family protein
HER15_14760	COG0456	acetyltransferase
HER15_14780	COG0277	FAD linked oxidase domain protein
HER15_14780	COG0247	lactate metabolic process
HER15_14790	COG5383	Protein conserved in bacteria
HER15_14800	COG0556	nucleotide-excision repair
HER15_14825	COG1131	(ABC) transporter
HER15_14845	COG0237	dephospho-CoA kinase activity
HER15_14855	COG1862	Preprotein translocase
HER15_14865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HER15_14875	COG1132	(ABC) transporter
HER15_14885	COG1169	isochorismate synthase
HER15_14905	COG0009	L-threonylcarbamoyladenylate synthase
HER15_14935	COG0531	amino acid
HER15_14940	COG3256	nitric oxide reductase
HER15_14945	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HER15_14950	COG1959	2 iron, 2 sulfur cluster binding
HER15_14970	COG0534	Mate efflux family protein
HER15_14975	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HER15_15035	COG2201	protein-glutamate methylesterase activity
HER15_15040	COG4251	negative regulation of phosphorylation
HER15_15050	COG1917	Cupin 2, conserved barrel domain protein
HER15_15050	COG4977	sequence-specific DNA binding
HER15_15080	COG1678	Uncharacterized ACR, COG1678
HER15_15085	COG3279	Response regulator of the LytR AlgR family
HER15_15090	COG3275	phosphorelay sensor kinase activity
HER15_15140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HER15_15155	COG1595	DNA-templated transcription, initiation
HER15_15160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HER15_15165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HER15_15185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HER15_15200	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HER15_15205	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HER15_15230	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HER15_15245	COG0653	protein targeting
HER15_15255	COG2096	Adenosyltransferase
HER15_15260	COG0824	Thioesterase