locus-tag	class	description
PG912_00010	COG1597	lipid kinase activity
PG912_00015	COG0557	exoribonuclease II activity
PG912_00030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PG912_00035	COG0393	Putative heavy-metal-binding
PG912_00055	COG0445	tRNA wobble uridine modification
PG912_00060	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PG912_00075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PG912_00075	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
PG912_00090	COG0420	3'-5' exonuclease activity
PG912_00095	COG0419	ATPase involved in DNA repair
PG912_00105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PG912_00110	COG1988	membrane-bound metal-dependent
PG912_00115	COG0697	spore germination
PG912_00125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PG912_00125	COG0758	DNA mediated transformation
PG912_00135	COG1607	acyl-coa hydrolase
PG912_00140	COG0628	permease
PG912_00160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PG912_00165	COG4172	Belongs to the ABC transporter superfamily
PG912_00175	COG0488	(ABC) transporter
PG912_00185	COG0745	RESPONSE REGULATOR receiver
PG912_00190	COG5002	protein histidine kinase activity
PG912_00205	COG0793	Belongs to the peptidase S41A family
PG912_00210	COG0594	ribonuclease P activity
PG912_00240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PG912_00245	COG2197	response regulator
PG912_00265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PG912_00280	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PG912_00290	COG0720	synthase
PG912_00295	COG0193	aminoacyl-tRNA hydrolase activity
PG912_00300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PG912_00305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PG912_00345	COG0598	Magnesium transport protein CorA
PG912_00355	COG0189	ligase activity
PG912_00365	COG0315	cyclic pyranopterin monophosphate synthase activity
PG912_00365	COG0746	molybdenum cofactor guanylyltransferase activity
PG912_00370	COG0315	cyclic pyranopterin monophosphate synthase activity
PG912_00375	COG2827	Endonuclease containing a URI domain
PG912_00380	COG2827	Endonuclease containing a URI domain
PG912_00385	COG0303	'Molybdopterin
PG912_00390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PG912_00395	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PG912_00405	COG1752	Esterase of the alpha-beta hydrolase superfamily
PG912_00410	COG1530	ribonuclease E activity
PG912_00415	COG0776	regulation of translation
PG912_00420	COG1194	a g-specific adenine glycosylase
PG912_00425	COG0629	single-stranded DNA binding
PG912_00455	COG0612	Peptidase, M16
PG912_00460	COG0612	Peptidase, M16
PG912_00465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PG912_00470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PG912_00515	COG0356	it plays a direct role in the translocation of protons across the membrane
PG912_00520	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PG912_00525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PG912_00530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PG912_00535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PG912_00540	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PG912_00545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PG912_00550	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PG912_00605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PG912_00630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PG912_00635	COG0196	riboflavin kinase activity
PG912_00640	COG1629	transport
PG912_00650	COG0423	glycine-tRNA ligase activity
PG912_00670	COG1040	competence protein
PG912_00685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PG912_00685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PG912_00690	COG1408	metallophosphoesterase
PG912_00715	COG3275	phosphorelay sensor kinase activity
PG912_00745	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PG912_00755	COG0460	homoserine dehydrogenase
PG912_00755	COG0527	aspartate kinase activity
PG912_00770	COG1999	signal sequence binding
PG912_00800	COG0584	glycerophosphoryl diester phosphodiesterase
PG912_00825	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PG912_00840	COG1115	amino acid carrier protein
PG912_00855	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PG912_00860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PG912_00870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PG912_00895	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PG912_00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PG912_00920	COG0297	glycogen (starch) synthase activity
PG912_00925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PG912_00940	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PG912_00950	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PG912_00975	COG1054	Belongs to the UPF0176 family
PG912_01010	COG0109	protoheme IX farnesyltransferase activity
PG912_01035	COG1999	signal sequence binding
PG912_01040	COG2322	membrane
PG912_01055	COG1214	PFAM Peptidase M22, glycoprotease
PG912_01060	COG0668	transmembrane transport
PG912_01065	COG3759	membrane
PG912_01080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PG912_01085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PG912_01090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PG912_01095	COG0571	ribonuclease III activity
PG912_01105	COG0469	pyruvate kinase activity
PG912_01120	COG0519	Catalyzes the synthesis of GMP from XMP
PG912_01125	COG0629	single-stranded DNA binding
PG912_01130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PG912_01165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PG912_01165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PG912_01170	COG1619	proteins homologs of microcin C7 resistance protein MccF
PG912_01175	COG0792	nuclease activity
PG912_01185	COG1028	Short-chain dehydrogenase reductase Sdr
PG912_01200	COG0288	reversible hydration of carbon dioxide
PG912_01205	COG0659	secondary active sulfate transmembrane transporter activity
PG912_01240	COG2304	oxidoreductase activity
PG912_01245	COG2304	oxidoreductase activity
PG912_01275	COG0590	tRNA wobble adenosine to inosine editing
PG912_01290	COG0084	hydrolase, TatD family'
PG912_01310	COG0436	Aminotransferase
PG912_01315	COG3239	Fatty acid desaturase
PG912_01320	COG0357	Ribosomal RNA small subunit methyltransferase G
PG912_01360	COG4771	TonB-dependent receptor
PG912_01370	COG0803	Belongs to the bacterial solute-binding protein 9 family
PG912_01385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PG912_01390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PG912_01395	COG1074	ATP-dependent DNA helicase activity
PG912_01400	COG0156	8-amino-7-oxononanoate synthase activity
PG912_01410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PG912_01415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PG912_01420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PG912_01435	COG1595	DNA-templated transcription, initiation
PG912_01445	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PG912_01450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PG912_01470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PG912_01475	COG2268	Band 7 protein
PG912_01495	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PG912_01505	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PG912_01535	COG0508	dehydrogenase complex catalyzes the overall conversion of
PG912_01570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PG912_01585	COG0719	Fe-S assembly protein
PG912_01590	COG0396	ATPase activity
PG912_01600	COG0719	Fe-S assembly protein
PG912_01615	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PG912_01620	COG1652	LysM domain
PG912_01630	COG1561	YicC-like family, N-terminal region
PG912_01635	COG0194	GDP metabolic process
PG912_01640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PG912_01645	COG4942	peptidase
PG912_01660	COG5002	protein histidine kinase activity
PG912_01665	COG3279	Response regulator of the LytR AlgR family
PG912_01670	COG2258	MOSC domain
PG912_01675	COG3409	Peptidoglycan-binding domain 1 protein
PG912_01675	COG0793	Belongs to the peptidase S41A family
PG912_01690	COG1522	sequence-specific DNA binding
PG912_01710	COG3655	Transcriptional regulator
PG912_01715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PG912_01730	COG0484	heat shock protein binding
PG912_01735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PG912_01750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PG912_01765	COG2391	methyltransferase activity
PG912_01780	COG0439	Biotin carboxylase
PG912_01785	COG0511	ligase activity, forming carbon-carbon bonds
PG912_01790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PG912_01795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PG912_01805	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PG912_01810	COG0307	riboflavin synthase, alpha
PG912_01850	COG3275	phosphorelay sensor kinase activity
PG912_01860	COG2137	regulation of response to DNA damage stimulus
PG912_01870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PG912_01885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PG912_01890	COG1968	undecaprenyl-diphosphatase activity
PG912_01900	COG2177	Part of the ABC transporter FtsEX involved in
PG912_01905	COG0346	lactoylglutathione lyase activity
PG912_01920	COG4585	Histidine kinase
PG912_01930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PG912_01935	COG4591	ABC-type transport system involved in lipoprotein release permease component
PG912_01940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PG912_01945	COG0481	GTPase activity
PG912_01955	COG0252	asparaginase activity
PG912_01960	COG0811	peptide transport
PG912_01970	COG0848	biopolymer transport protein
PG912_01990	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PG912_01995	COG0017	Asparaginyl-tRNA synthetase
PG912_02015	COG0233	cytoplasmic translational termination
PG912_02020	COG0528	UMP kinase activity
PG912_02025	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PG912_02030	COG0052	Belongs to the universal ribosomal protein uS2 family
PG912_02035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PG912_02040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PG912_02045	COG1368	sulfuric ester hydrolase activity
PG912_02055	COG1477	protein flavinylation
PG912_02060	COG2226	methyltransferase
PG912_02080	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PG912_02090	COG0501	Belongs to the peptidase M48B family
PG912_02095	COG3186	Phenylalanine-4-hydroxylase
PG912_02110	COG0789	Transcriptional regulator
PG912_02115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PG912_02140	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
PG912_02150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PG912_02160	COG0702	epimerase
PG912_02175	COG0386	Belongs to the glutathione peroxidase family
PG912_02185	COG0415	Belongs to the DNA photolyase family
PG912_02205	COG1704	LemA family
PG912_02240	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PG912_02265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PG912_02285	COG1160	GTP binding
PG912_02295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PG912_02315	COG1032	radical SAM domain protein
PG912_02325	COG1032	radical SAM domain protein
PG912_02335	COG2192	nodulation
PG912_02340	COG2192	nodulation
PG912_02370	COG2264	protein methyltransferase activity
PG912_02375	COG1032	radical SAM domain protein
PG912_02380	COG0641	radical SAM
PG912_02420	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PG912_02425	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PG912_02425	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PG912_02430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PG912_02435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PG912_02440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PG912_02470	COG3938	Belongs to the proline racemase family
PG912_02480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PG912_02495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PG912_02515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PG912_02525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PG912_02535	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PG912_02540	COG0596	Alpha beta hydrolase
PG912_02545	COG0101	tRNA pseudouridine synthase activity
PG912_02555	COG1950	PFAM Membrane protein of
PG912_02560	COG0544	peptidyl-prolyl cis-trans isomerase activity
PG912_02570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PG912_02580	COG0358	DNA primase activity
PG912_02585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PG912_02605	COG1428	Deoxynucleoside kinase
PG912_02610	COG1185	polyribonucleotide nucleotidyltransferase activity
PG912_02615	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PG912_02620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PG912_02625	COG0191	fructose-bisphosphate aldolase activity
PG912_02635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PG912_02640	COG1428	Deoxynucleoside kinase
PG912_02675	COG0321	lipoyl(octanoyl) transferase activity
PG912_02685	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PG912_02695	COG1490	D-aminoacyl-tRNA deacylase activity
PG912_02700	COG1162	GTPase activity
PG912_02710	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PG912_02720	COG0436	Aminotransferase
PG912_02730	COG0612	Peptidase, M16
PG912_02755	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PG912_02760	COG0616	signal peptide processing
PG912_02770	COG0519	Catalyzes the synthesis of GMP from XMP
PG912_02795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PG912_02805	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PG912_02805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PG912_02815	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PG912_02825	COG0596	Alpha beta hydrolase
PG912_02835	COG2363	Small membrane protein
PG912_02840	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PG912_02845	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PG912_02850	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PG912_02860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PG912_02870	COG2814	Major facilitator Superfamily
PG912_02900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PG912_02905	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PG912_02910	COG0492	ferredoxin-NADP+ reductase activity
PG912_02920	COG0459	protein refolding
PG912_02925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PG912_02945	COG3604	Transcriptional regulator
PG912_02950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PG912_02960	COG0010	Belongs to the arginase family
PG912_02965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PG912_02995	COG0488	(ABC) transporter
PG912_03000	COG2066	Belongs to the glutaminase family
PG912_03005	COG2515	1-aminocyclopropane-1-carboxylate deaminase
PG912_03010	COG3942	CHAP domain
PG912_03010	COG1705	Flagellar rod assembly protein muramidase FlgJ
PG912_03025	COG3275	phosphorelay sensor kinase activity
PG912_03030	COG3279	Response regulator of the LytR AlgR family
PG912_03035	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PG912_03060	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PG912_03090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PG912_03100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PG912_03120	COG0339	signal peptide processing
PG912_03125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PG912_03130	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PG912_03140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PG912_03155	COG4191	Histidine kinase
PG912_03180	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PG912_03185	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PG912_03200	COG2072	flavoprotein involved in K transport
PG912_03220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PG912_03235	COG0159	tryptophan synthase activity
PG912_03245	COG0135	phosphoribosylanthranilate isomerase activity
PG912_03250	COG0134	indole-3-glycerol-phosphate synthase activity
PG912_03255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PG912_03260	COG0512	Glutamine amidotransferase of anthranilate synthase
PG912_03265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PG912_03270	COG0367	asparagine synthase
PG912_03275	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
PG912_03280	COG0187	DNA topoisomerase II activity
PG912_03300	COG2884	Cell division ATP-binding protein ftsE
PG912_03325	COG1574	metal-dependent hydrolase with the TIM-barrel fold
PG912_03330	COG1595	DNA-templated transcription, initiation
PG912_03345	COG4946	Tricorn protease homolog
PG912_03345	COG0793	Belongs to the peptidase S41A family
PG912_03355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PG912_03360	COG0284	orotidine-5'-phosphate decarboxylase activity
PG912_03365	COG0601	transmembrane transport
PG912_03375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PG912_03385	COG0149	triose-phosphate isomerase activity
PG912_03390	COG2264	protein methyltransferase activity
PG912_03405	COG2885	chlorophyll binding
PG912_03410	COG2885	chlorophyll binding
PG912_03455	COG0174	glutamine synthetase
PG912_03495	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PG912_03540	COG1129	ABC transporter
PG912_03545	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PG912_03565	COG3530	Putative quorum-sensing-regulated virulence factor
PG912_03580	COG4452	Inner membrane protein CreD
PG912_03630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PG912_03640	COG0569	domain protein
PG912_03645	COG2003	Belongs to the UPF0758 family
PG912_03660	COG1011	Hydrolase
PG912_03670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PG912_03680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PG912_03690	COG1629	transport
PG912_03690	COG4206	TonB-dependent receptor
PG912_03700	COG1629	transport
PG912_03705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PG912_03710	COG0049	tRNA binding
PG912_03715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PG912_03720	COG0051	transcription antitermination factor activity, RNA binding
PG912_03725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PG912_03730	COG0088	Forms part of the polypeptide exit tunnel
PG912_03735	COG0089	rRNA binding
PG912_03740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PG912_03745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PG912_03750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PG912_03755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PG912_03760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PG912_03765	COG0255	Belongs to the universal ribosomal protein uL29 family
PG912_03770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PG912_03775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PG912_03780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PG912_03790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PG912_03795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PG912_03800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PG912_03805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PG912_03810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PG912_03815	COG1841	ribosomal large subunit assembly
PG912_03820	COG0200	Binds to the 23S rRNA
PG912_03830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PG912_03835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PG912_03840	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PG912_03845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PG912_03850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PG912_03855	COG0202	RNA polymerase activity
PG912_03860	COG0203	ribosomal protein L17
PG912_03865	COG0505	Belongs to the CarA family
PG912_03870	COG0148	phosphopyruvate hydratase activity
PG912_03880	COG0010	Belongs to the arginase family
PG912_03890	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PG912_03910	COG2022	thiamine diphosphate biosynthetic process
PG912_03915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PG912_03925	COG0300	oxidoreductase activity
PG912_03930	COG2234	aminopeptidase activity
PG912_03935	COG1120	ATPase activity
PG912_03940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PG912_03945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PG912_03960	COG1476	TRANSCRIPTIONal
PG912_03965	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PG912_03975	COG0339	signal peptide processing
PG912_03985	COG1295	ribonuclease BN
PG912_03990	COG0124	histidyl-tRNA synthetase
PG912_03995	COG0302	gtp cyclohydrolase
PG912_04000	COG1278	Cold shock
PG912_04005	COG1278	Cold shock
PG912_04035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PG912_04045	COG2329	Antibiotic biosynthesis monooxygenase
PG912_04055	COG4166	transmembrane transport
PG912_04075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PG912_04085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PG912_04095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PG912_04105	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PG912_04120	COG0105	UTP biosynthetic process
PG912_04125	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PG912_04140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PG912_04145	COG0671	phosphoesterase, PA-phosphatase related
PG912_04155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PG912_04175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PG912_04245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PG912_04250	COG0542	response to heat
PG912_04265	COG0791	NLP P60 protein
PG912_04270	COG0183	Belongs to the thiolase family
PG912_04295	COG3422	double-strand break repair
PG912_04305	COG1476	TRANSCRIPTIONal
PG912_04395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PG912_04455	COG1678	Uncharacterized ACR, COG1678
PG912_04460	COG3279	Response regulator of the LytR AlgR family
PG912_04465	COG3275	phosphorelay sensor kinase activity
PG912_04505	COG4771	TonB-dependent receptor
PG912_04515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PG912_04520	COG1595	DNA-templated transcription, initiation
PG912_04525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PG912_04530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PG912_04545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PG912_04560	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
PG912_04570	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
PG912_04575	COG1902	pentaerythritol trinitrate reductase activity
PG912_04600	COG0681	Belongs to the peptidase S26 family
PG912_04605	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PG912_04615	COG1475	DNA binding
PG912_04620	COG1192	Involved in chromosome partitioning
PG912_04625	COG0592	DNA-directed DNA polymerase activity
PG912_04635	COG2326	polyphosphate kinase activity
PG912_04655	COG1104	cysteine desulfurase activity
PG912_04690	COG1663	tetraacyldisaccharide 4'-kinase activity
PG912_04745	COG0254	rRNA binding
PG912_04750	COG0069	glutamate synthase activity
PG912_04755	COG2813	Specifically methylates the guanine in position
PG912_04775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PG912_04780	COG1414	Transcriptional regulator
PG912_04795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PG912_04855	COG1132	(ABC) transporter
PG912_04865	COG3104	oligopeptide transport
PG912_04870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PG912_04885	COG4589	Belongs to the CDS family
PG912_04895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PG912_04900	COG0799	negative regulation of ribosome biogenesis
PG912_04915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PG912_04920	COG1051	belongs to the nudix hydrolase family
PG912_04925	COG0443	Heat shock 70 kDa protein
PG912_04930	COG3275	phosphorelay sensor kinase activity
PG912_04935	COG3275	phosphorelay sensor kinase activity
PG912_04940	COG3279	Response regulator of the LytR AlgR family
PG912_04990	COG1252	NADH dehydrogenase
PG912_05005	COG2207	Transcriptional regulator
PG912_05010	COG0655	NAD(P)H dehydrogenase (quinone) activity
PG912_05015	COG2326	polyphosphate kinase activity
PG912_05030	COG1472	Belongs to the glycosyl hydrolase 3 family
PG912_05055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PG912_05115	COG0326	Molecular chaperone. Has ATPase activity
PG912_05120	COG0673	inositol 2-dehydrogenase activity
PG912_05125	COG0673	inositol 2-dehydrogenase activity
PG912_05130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PG912_05145	COG1234	tRNA 3'-trailer cleavage
PG912_05165	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PG912_05170	COG0659	secondary active sulfate transmembrane transporter activity
PG912_05175	COG0583	DNA-binding transcription factor activity
PG912_05180	COG0783	Belongs to the Dps family
PG912_05190	COG1858	cytochrome C peroxidase
PG912_05200	COG1917	Cupin 2, conserved barrel domain protein
PG912_05200	COG2207	Transcriptional regulator
PG912_05205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PG912_05220	COG1132	(ABC) transporter
PG912_05255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PG912_05260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PG912_05290	COG1702	phosphate starvation-inducible protein PhoH
PG912_05300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PG912_05310	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PG912_05330	COG0156	8-amino-7-oxononanoate synthase activity
PG912_05445	COG3275	phosphorelay sensor kinase activity
PG912_05450	COG0793	Belongs to the peptidase S41A family
PG912_05465	COG0527	aspartate kinase activity
PG912_05465	COG0460	homoserine dehydrogenase
PG912_05475	COG1959	2 iron, 2 sulfur cluster binding
PG912_05485	COG0175	sulfate reduction
PG912_05490	COG0175	sulfate reduction
PG912_05500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PG912_05505	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PG912_05520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PG912_05520	COG1648	precorrin-2 dehydrogenase activity
PG912_05530	COG0633	Ferredoxin
PG912_05535	COG1045	serine acetyltransferase
PG912_05565	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PG912_05575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PG912_05580	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PG912_05585	COG0066	3-isopropylmalate dehydratase activity
PG912_05605	COG0165	Argininosuccinate lyase
PG912_05615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PG912_05625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PG912_05635	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PG912_05640	COG0137	argininosuccinate synthase activity
PG912_05655	COG0129	dihydroxy-acid dehydratase activity
PG912_05660	COG0028	Belongs to the TPP enzyme family
PG912_05665	COG0440	acetolactate synthase activity
PG912_05670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PG912_05675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PG912_05680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PG912_05690	COG0076	glutamate decarboxylase activity
PG912_05700	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PG912_05710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PG912_05735	COG0360	Binds together with S18 to 16S ribosomal RNA
PG912_05740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PG912_05745	COG0359	binds to the 23S rRNA
PG912_05750	COG0019	diaminopimelate decarboxylase activity
PG912_05760	COG0776	regulation of translation
PG912_05765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PG912_05770	COG0514	ATP-dependent DNA helicase (RecQ)
PG912_05790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PG912_05795	COG0714	Associated with various cellular activities
PG912_05805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PG912_05810	COG1250	3-hydroxyacyl-CoA dehydrogenase
PG912_05815	COG0673	inositol 2-dehydrogenase activity
PG912_05820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PG912_05835	COG0813	purine-nucleoside phosphorylase activity
PG912_05865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PG912_05870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PG912_05875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PG912_05875	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
PG912_05915	COG0714	Associated with various cellular activities
PG912_05940	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PG912_05990	COG3340	Belongs to the peptidase S51 family
PG912_05995	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PG912_06000	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PG912_06035	COG2270	Major facilitator Superfamily
PG912_06040	COG0564	pseudouridine synthase activity
PG912_06045	COG1022	Amp-dependent synthetase and ligase
PG912_06050	COG1022	Amp-dependent synthetase and ligase
PG912_06055	COG3279	Response regulator of the LytR AlgR family
PG912_06060	COG3275	phosphorelay sensor kinase activity
PG912_06070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PG912_06075	COG1131	(ABC) transporter
PG912_06095	COG3279	Response regulator of the LytR AlgR family
PG912_06100	COG3275	phosphorelay sensor kinase activity
PG912_06105	COG1131	(ABC) transporter
PG912_06120	COG3275	phosphorelay sensor kinase activity
PG912_06125	COG3279	Response regulator of the LytR AlgR family
PG912_06155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PG912_06165	COG1476	TRANSCRIPTIONal
PG912_06170	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PG912_06175	COG0083	homoserine kinase activity
PG912_06200	COG0437	4 iron, 4 sulfur cluster binding
PG912_06245	COG0515	serine threonine protein kinase
PG912_06245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PG912_06280	COG1166	arginine decarboxylase activity
PG912_06285	COG0010	Belongs to the arginase family
PG912_06320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PG912_06350	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PG912_06350	COG0047	phosphoribosylformylglycinamidine synthase activity
PG912_06375	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PG912_06380	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PG912_06390	COG3958	Transketolase
PG912_06395	COG0424	maF-like protein
PG912_06405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PG912_06420	COG0542	response to heat
PG912_06435	COG2340	Cysteine-rich secretory protein family
PG912_06450	COG2373	Large extracellular alpha-helical protein
PG912_06470	COG0513	Belongs to the DEAD box helicase family
PG912_06480	COG4953	penicillin-binding protein 1C
PG912_06495	COG3263	regulation of cellular component size
PG912_06500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PG912_06505	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PG912_06525	COG1253	flavin adenine dinucleotide binding
PG912_06540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PG912_06545	COG2346	COG2346, Truncated hemoglobins
PG912_06560	COG1607	acyl-coa hydrolase
PG912_06590	COG0488	(ABC) transporter
PG912_06625	COG1363	Peptidase, m42
PG912_06650	COG0167	dihydroorotate dehydrogenase activity
PG912_06665	COG2318	DinB family
PG912_06675	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PG912_06680	COG0564	pseudouridine synthase activity
PG912_06685	COG3279	Response regulator of the LytR AlgR family
PG912_06690	COG3275	phosphorelay sensor kinase activity
PG912_06735	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PG912_06775	COG3813	Protein conserved in bacteria
PG912_06785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PG912_06790	COG2890	protein-(glutamine-N5) methyltransferase activity
PG912_06810	COG1011	Hydrolase
PG912_06815	COG0697	spore germination
PG912_06820	COG1739	Uncharacterized protein family UPF0029
PG912_06840	COG2267	carboxylic ester hydrolase activity
PG912_06850	COG0539	negative regulation of cytoplasmic translation
PG912_06860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PG912_06875	COG1522	sequence-specific DNA binding
PG912_06880	COG0564	pseudouridine synthase activity
PG912_06885	COG2814	Major facilitator Superfamily
PG912_06895	COG0604	alcohol dehydrogenase
PG912_06905	COG0783	Belongs to the Dps family
PG912_07005	COG1136	(ABC) transporter
PG912_07010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PG912_07015	COG2204	response regulator
PG912_07020	COG4191	Histidine kinase
PG912_07035	COG1278	Cold shock
PG912_07055	COG1322	Protein conserved in bacteria
PG912_07060	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PG912_07070	COG1028	Short-chain dehydrogenase reductase Sdr
PG912_07075	COG0612	Peptidase, M16
PG912_07080	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PG912_07085	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PG912_07090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PG912_07095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PG912_07100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PG912_07100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PG912_07105	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PG912_07110	COG1078	dGTPase activity
PG912_07115	COG2204	response regulator
PG912_07125	COG0686	Belongs to the AlaDH PNT family
PG912_07140	COG0514	ATP-dependent DNA helicase (RecQ)
PG912_07150	COG0805	protein transport
PG912_07160	COG1137	ATPase activity
PG912_07165	COG1183	phosphatidylcholine synthase activity
PG912_07180	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PG912_07190	COG4974	Belongs to the 'phage' integrase family
PG912_07205	COG0463	Glycosyl transferase, family 2
PG912_07210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PG912_07215	COG1132	(ABC) transporter
PG912_07220	COG0517	IMP dehydrogenase activity
PG912_07220	COG0617	tRNA 3'-terminal CCA addition
PG912_07220	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PG912_07235	COG0438	transferase activity, transferring glycosyl groups
PG912_07255	COG0242	peptide deformylase activity
PG912_07265	COG3956	TIGRFAM MazG family protein
PG912_07270	COG1028	Short-chain dehydrogenase reductase Sdr
PG912_07285	COG3279	Response regulator of the LytR AlgR family
PG912_07315	COG2972	Histidine kinase
PG912_07325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PG912_07335	COG0456	acetyltransferase
PG912_07345	COG1028	Short-chain dehydrogenase reductase Sdr
PG912_07350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PG912_07365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PG912_07370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PG912_07380	COG0577	efflux transmembrane transporter activity
PG912_07380	COG1136	(ABC) transporter
PG912_07385	COG0577	efflux transmembrane transporter activity
PG912_07385	COG1136	(ABC) transporter
PG912_07390	COG1136	(ABC) transporter
PG912_07395	COG3011	Protein conserved in bacteria
PG912_07445	COG1595	DNA-templated transcription, initiation
PG912_07470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PG912_07475	COG0402	S-adenosylhomocysteine deaminase activity
PG912_07480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PG912_07495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PG912_07510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PG912_07525	COG0484	heat shock protein binding
PG912_07530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PG912_07535	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PG912_07565	COG2897	thiosulfate sulfurtransferase activity
PG912_07570	COG1301	dicarboxylic acid transport
PG912_07600	COG0668	transmembrane transport
PG912_07620	COG0517	IMP dehydrogenase activity
PG912_07620	COG0516	GMP reductase activity
PG912_07645	COG1730	sister chromatid segregation
PG912_07665	COG1595	DNA-templated transcription, initiation
PG912_07685	COG0525	valine-tRNA ligase activity
PG912_07700	COG0436	Aminotransferase
PG912_07705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PG912_07725	COG3119	arylsulfatase activity
PG912_07750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PG912_07765	COG3876	Protein conserved in bacteria
PG912_07775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PG912_07780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PG912_07780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PG912_07795	COG2860	membrane
PG912_07820	COG0012	GTP binding
PG912_07825	COG4771	TonB-dependent receptor
PG912_07830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PG912_07845	COG1131	(ABC) transporter
PG912_07875	COG0302	gtp cyclohydrolase
PG912_07880	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PG912_07885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PG912_07895	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PG912_07900	COG0322	excinuclease ABC activity
PG912_07905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PG912_07910	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PG912_07935	COG0697	spore germination
PG912_07950	COG0140	phosphoribosyl-ATP diphosphatase activity
PG912_07950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PG912_07955	COG0107	imidazoleglycerol-phosphate synthase activity
PG912_07960	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PG912_07970	COG0131	Imidazoleglycerol-phosphate dehydratase
PG912_07975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PG912_07980	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PG912_07985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PG912_08020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PG912_08025	COG0438	transferase activity, transferring glycosyl groups
PG912_08030	COG3959	Transketolase, thiamine diphosphate binding domain
PG912_08040	COG1715	Restriction endonuclease
PG912_08060	COG2195	Cleaves the N-terminal amino acid of tripeptides
PG912_08080	COG0116	Belongs to the methyltransferase superfamily
PG912_08085	COG0500	methyltransferase
PG912_08105	COG0433	COG0433 Predicted ATPase
PG912_08135	COG0343	queuine tRNA-ribosyltransferase activity
PG912_08140	COG1187	pseudouridine synthase activity
PG912_08180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PG912_08190	COG0564	pseudouridine synthase activity
PG912_08200	COG1181	Belongs to the D-alanine--D-alanine ligase family
PG912_08210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PG912_08220	COG1595	DNA-templated transcription, initiation
PG912_08245	COG1607	acyl-coa hydrolase
PG912_08260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PG912_08275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PG912_08280	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PG912_08285	COG0504	CTP synthase activity
PG912_08290	COG0706	membrane insertase activity
PG912_08295	COG1446	asparaginase
PG912_08315	COG0590	tRNA wobble adenosine to inosine editing
PG912_08325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PG912_08330	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PG912_08350	COG1595	DNA-templated transcription, initiation
PG912_08360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PG912_08400	COG1090	epimerase
PG912_08415	COG0508	dehydrogenase complex catalyzes the overall conversion of
PG912_08420	COG0556	nucleotide-excision repair
PG912_08430	COG0408	coproporphyrinogen oxidase activity
PG912_08445	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PG912_08455	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PG912_08460	COG0113	porphobilinogen synthase activity
PG912_08470	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PG912_08485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PG912_08495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PG912_08500	COG2195	Cleaves the N-terminal amino acid of tripeptides
PG912_08505	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
PG912_08510	COG0405	Gamma-glutamyltransferase
PG912_08525	COG0336	Belongs to the RNA methyltransferase TrmD family
PG912_08530	COG0463	Glycosyl transferase, family 2
PG912_08535	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PG912_08540	COG0335	large ribosomal subunit rRNA binding
PG912_08550	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
PG912_08590	COG1418	mRNA catabolic process
PG912_08625	COG4974	Belongs to the 'phage' integrase family
PG912_08655	COG2826	transposase and inactivated derivatives, IS30 family
PG912_08750	COG3541	Predicted nucleotidyltransferase
PG912_08775	COG2815	serine threonine protein kinase
PG912_08775	COG0515	serine threonine protein kinase
PG912_08785	COG0732	type I restriction modification DNA specificity domain
PG912_08830	COG0739	heme binding
PG912_08950	COG2826	transposase and inactivated derivatives, IS30 family
PG912_08965	COG2826	transposase and inactivated derivatives, IS30 family
PG912_08980	COG1393	Belongs to the ArsC family
PG912_08985	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PG912_09010	COG3275	phosphorelay sensor kinase activity
PG912_09035	COG3279	Response regulator of the LytR AlgR family
PG912_09040	COG0010	Belongs to the arginase family
PG912_09045	COG1228	amidohydrolase
PG912_09055	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PG912_09060	COG0497	DNA recombination
PG912_09085	COG1528	Iron-storage protein
PG912_09090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PG912_09135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PG912_09140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PG912_09150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PG912_09160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PG912_09165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PG912_09170	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PG912_09175	COG0824	Thioesterase
PG912_09190	COG0653	protein targeting
PG912_09220	COG0534	Mate efflux family protein
PG912_09225	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PG912_09235	COG1674	ftsk spoiiie
PG912_09250	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PG912_09250	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PG912_09265	COG0482	sulfurtransferase activity
PG912_09300	COG0018	arginyl-trna synthetase
PG912_09305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PG912_09315	COG0488	(ABC) transporter
PG912_09325	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PG912_09335	COG1741	Belongs to the pirin family
PG912_09380	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PG912_09390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PG912_09405	COG0217	transcriptional regulatory protein
PG912_09410	COG1629	transport
PG912_09420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PG912_09425	COG1266	CAAX protease self-immunity
PG912_09430	COG4948	Mandelate Racemase Muconate Lactonizing
PG912_09440	COG1575	Belongs to the MenA family. Type 1 subfamily
PG912_09445	COG2181	nitrate reductase activity
PG912_09445	COG0247	lactate metabolic process
PG912_09450	COG2181	nitrate reductase activity
PG912_09450	COG0247	lactate metabolic process
PG912_09465	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PG912_09470	COG0251	oxidation-reduction process
PG912_09485	COG1803	Methylglyoxal synthase
PG912_09500	COG0205	6-phosphofructokinase activity
PG912_09510	COG1609	Transcriptional regulator
PG912_09515	COG1609	Transcriptional regulator
PG912_09525	COG3525	Glycosyl hydrolase, family 20, catalytic domain
PG912_09530	COG0363	glucosamine-6-phosphate deaminase activity
PG912_09540	COG1629	transport
PG912_09550	COG3279	Response regulator of the LytR AlgR family
PG912_09570	COG1760	l-serine dehydratase
PG912_09580	COG3022	response to hydroperoxide
PG912_09585	COG0321	lipoyl(octanoyl) transferase activity
PG912_09585	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PG912_09645	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
PG912_09650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PG912_09660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PG912_09685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PG912_09705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PG912_09710	COG0488	(ABC) transporter
PG912_09785	COG2050	protein possibly involved in aromatic compounds catabolism
PG912_09795	COG1169	isochorismate synthase
PG912_09810	COG1132	(ABC) transporter
PG912_09820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PG912_09830	COG1862	Preprotein translocase
PG912_09855	COG1131	(ABC) transporter
PG912_09890	COG0556	nucleotide-excision repair
PG912_09905	COG0045	succinate-CoA ligase (ADP-forming) activity
PG912_09945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PG912_09960	COG0552	protein localization to endoplasmic reticulum
PG912_09970	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PG912_09975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PG912_09980	COG1058	Belongs to the CinA family
PG912_09980	COG1546	Belongs to the CinA family
PG912_09985	COG0179	Fumarylacetoacetate (FAA) hydrolase
PG912_10000	COG2996	Protein conserved in bacteria
PG912_10005	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
PG912_10010	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PG912_10030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PG912_10105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PG912_10150	COG2072	flavoprotein involved in K transport
PG912_10175	COG1073	alpha beta
PG912_10205	COG0589	response to stress
PG912_10220	COG0348	domain, Protein
PG912_10250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PG912_10255	COG0813	purine-nucleoside phosphorylase activity
PG912_10260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PG912_10270	COG2217	Heavy metal translocating P-type atpase
PG912_10285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PG912_10295	COG0222	ribosome binding
PG912_10300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PG912_10305	COG0081	regulation of translation
PG912_10310	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PG912_10330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PG912_10365	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PG912_10380	COG1115	amino acid carrier protein
PG912_10395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PG912_10425	COG0778	Nitroreductase
PG912_10430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PG912_10475	COG3279	Response regulator of the LytR AlgR family
PG912_10485	COG3118	belongs to the thioredoxin family
PG912_10490	COG0450	alkyl hydroperoxide reductase
PG912_10500	COG3264	Mechanosensitive ion channel
PG912_10500	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
PG912_10505	COG1668	transmembrane transport
PG912_10510	COG4152	abc transporter atp-binding protein
PG912_10520	COG1024	Enoyl-CoA hydratase
PG912_10520	COG1250	3-hydroxyacyl-CoA dehydrogenase
PG912_10525	COG0183	Belongs to the thiolase family
PG912_10530	COG1960	acyl-CoA dehydrogenase activity
PG912_10565	COG0492	ferredoxin-NADP+ reductase activity
PG912_10605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PG912_10620	COG2197	response regulator
PG912_10630	COG4585	Histidine kinase
PG912_10640	COG0101	tRNA pseudouridine synthase activity
PG912_10645	COG1132	(ABC) transporter
PG912_10665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PG912_10680	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PG912_10705	COG0572	uridine kinase
PG912_10715	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PG912_10725	COG0688	phosphatidylethanolamine metabolic process
PG912_10730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PG912_10730	COG1333	cytochrome c biogenesis protein
PG912_10750	COG0489	protein tyrosine kinase activity
PG912_10750	COG3206	protein involved in exopolysaccharide biosynthesis
PG912_10755	COG4464	protein tyrosine phosphatase activity
PG912_10765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PG912_10770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PG912_10785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PG912_10790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PG912_10790	COG0519	Catalyzes the synthesis of GMP from XMP
PG912_10815	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PG912_10820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PG912_10825	COG0110	maltose O-acetyltransferase activity
PG912_10830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PG912_10840	COG0297	glycogen (starch) synthase activity
PG912_10840	COG0438	transferase activity, transferring glycosyl groups
PG912_10845	COG0367	asparagine synthase
PG912_10850	COG1215	transferase activity, transferring glycosyl groups
PG912_10865	COG0438	transferase activity, transferring glycosyl groups
PG912_10870	COG0438	transferase activity, transferring glycosyl groups
PG912_10875	COG0438	transferase activity, transferring glycosyl groups
PG912_10900	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PG912_10905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PG912_10925	COG0285	dihydrofolate synthase activity
PG912_10945	COG0848	biopolymer transport protein
PG912_10950	COG0811	peptide transport
PG912_10965	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PG912_10970	COG1960	acyl-CoA dehydrogenase activity
PG912_10980	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PG912_11040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PG912_11045	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PG912_11050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PG912_11065	COG2759	Belongs to the formate--tetrahydrofolate ligase family
PG912_11070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PG912_11080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PG912_11105	COG4206	TonB-dependent receptor
PG912_11105	COG1629	transport
PG912_11120	COG3279	Response regulator of the LytR AlgR family
PG912_11125	COG0791	NLP P60 protein
PG912_11130	COG0791	NLP P60 protein
PG912_11135	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PG912_11150	COG0793	Belongs to the peptidase S41A family
PG912_11210	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PG912_11225	COG2333	competence protein COMEC
PG912_11225	COG0658	competence protein
PG912_11230	COG4232	protein-disulfide reductase activity
PG912_11240	COG3104	oligopeptide transport
PG912_11245	COG1506	peptidase
PG912_11245	COG0823	Involved in the tonB-independent uptake of proteins
PG912_11330	COG3279	Response regulator of the LytR AlgR family
PG912_11355	COG1187	pseudouridine synthase activity
PG912_11380	COG0138	bifunctional purine biosynthesis protein purh
PG912_11385	COG1077	Cell shape determining protein MreB Mrl
PG912_11400	COG0768	penicillin binding
PG912_11405	COG0772	Belongs to the SEDS family
PG912_11410	COG0268	Binds directly to 16S ribosomal RNA
PG912_11425	COG0442	prolyl-tRNA aminoacylation
PG912_11440	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PG912_11445	COG2226	methyltransferase
PG912_11465	COG1595	DNA-templated transcription, initiation
PG912_11470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PG912_11475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PG912_11480	COG0517	IMP dehydrogenase activity
PG912_11495	COG1610	YqeY-like protein
PG912_11500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PG912_11515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PG912_11520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PG912_11525	COG0772	Belongs to the SEDS family
PG912_11530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PG912_11535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PG912_11540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PG912_11545	COG0768	penicillin binding
PG912_11555	COG0275	rRNA processing
PG912_11560	COG2001	Belongs to the MraZ family
PG912_11565	COG2267	carboxylic ester hydrolase activity
PG912_11570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PG912_11575	COG0564	pseudouridine synthase activity
PG912_11585	COG1012	belongs to the aldehyde dehydrogenase family
PG912_11615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PG912_11625	COG0668	transmembrane transport
PG912_11630	COG0668	transmembrane transport
PG912_11755	COG1522	sequence-specific DNA binding
PG912_11765	COG2095	MarC family integral membrane protein
PG912_11775	COG1757	Na H antiporter
PG912_11795	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PG912_11805	COG2824	Alkylphosphonate utilization operon protein PhnA
PG912_11810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PG912_11815	COG0228	four-way junction DNA binding
PG912_11820	COG1278	Cold shock
PG912_11840	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PG912_11850	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PG912_11860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PG912_11870	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PG912_11875	COG2086	electron transfer activity
PG912_11885	COG4771	TonB-dependent receptor
PG912_11890	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PG912_11895	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
PG912_11900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PG912_11915	COG2267	carboxylic ester hydrolase activity
PG912_11920	COG0037	tRNA processing
PG912_11925	COG0785	Cytochrome C biogenesis protein
PG912_11930	COG0606	chelatase, subunit chli
PG912_11935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PG912_11940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PG912_11985	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
PG912_11990	COG3256	nitric oxide reductase
PG912_12010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PG912_12010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PG912_12050	COG0583	DNA-binding transcription factor activity
PG912_12090	COG0514	ATP-dependent DNA helicase (RecQ)
PG912_12095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PG912_12100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PG912_12125	COG0437	4 iron, 4 sulfur cluster binding
PG912_12140	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PG912_12150	COG2166	iron-sulfur cluster assembly
PG912_12155	COG2151	metal-sulfur cluster biosynthetic enzyme
PG912_12175	COG1253	flavin adenine dinucleotide binding
PG912_12200	COG1573	uracil-dna glycosylase
PG912_12210	COG0513	Belongs to the DEAD box helicase family
PG912_12225	COG2197	response regulator
PG912_12230	COG3920	Histidine kinase
PG912_12240	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PG912_12250	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PG912_12255	COG1805	sodium ion transport
PG912_12260	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
PG912_12295	COG1012	belongs to the aldehyde dehydrogenase family
PG912_12305	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PG912_12310	COG0195	Participates in both transcription termination and antitermination
PG912_12315	COG0779	Required for maturation of 30S ribosomal subunits
PG912_12335	COG1435	thymidine kinase activity
PG912_12340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PG912_12345	COG1970	mechanosensitive ion channel activity
PG912_12360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PG912_12360	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
PG912_12405	COG1946	Acyl-CoA thioesterase
PG912_12425	COG0495	leucyl-tRNA aminoacylation
PG912_12445	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PG912_12465	COG0463	Glycosyl transferase, family 2
PG912_12480	COG0306	phosphate transporter
PG912_12505	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PG912_12525	COG1215	transferase activity, transferring glycosyl groups
PG912_12555	COG0509	glycine decarboxylation via glycine cleavage system
PG912_12565	COG0632	four-way junction helicase activity
PG912_12575	COG0840	transmembrane signaling receptor activity
PG912_12580	COG0840	transmembrane signaling receptor activity
PG912_12640	COG2095	MarC family integral membrane protein
PG912_12650	COG3279	Response regulator of the LytR AlgR family
PG912_12655	COG3275	phosphorelay sensor kinase activity
PG912_12675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PG912_12680	COG1053	succinate dehydrogenase
PG912_12715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PG912_12745	COG0006	proline dipeptidase activity
PG912_12755	COG0513	Belongs to the DEAD box helicase family
PG912_12820	COG1309	transcriptional regulator
PG912_12825	COG4335	DNA alkylation repair
PG912_12830	COG2207	Transcriptional regulator
PG912_12875	COG0024	Methionine aminopeptidase
PG912_12885	COG0110	maltose O-acetyltransferase activity
PG912_12970	COG2814	Major facilitator Superfamily
PG912_12975	COG4206	TonB-dependent receptor
PG912_12980	COG1381	Involved in DNA repair and RecF pathway recombination
PG912_12985	COG2954	triphosphatase activity
PG912_12990	COG1272	protein, Hemolysin III
PG912_13010	COG0667	Aldo Keto reductase
PG912_13015	COG0126	phosphoglycerate kinase activity
PG912_13020	COG0314	molybdopterin synthase activity
PG912_13050	COG1629	transport
PG912_13050	COG4206	TonB-dependent receptor
PG912_13055	COG0166	Belongs to the GPI family
PG912_13075	COG3185	4-Hydroxyphenylpyruvate dioxygenase
PG912_13080	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
PG912_13095	COG0492	ferredoxin-NADP+ reductase activity
PG912_13105	COG0489	protein tyrosine kinase activity
PG912_13115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PG912_13130	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PG912_13135	COG2267	carboxylic ester hydrolase activity
PG912_13170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PG912_13175	COG5000	phosphorelay sensor kinase activity
PG912_13180	COG1024	Enoyl-CoA hydratase
PG912_13190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PG912_13200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PG912_13205	COG0745	RESPONSE REGULATOR receiver
PG912_13205	COG2972	Histidine kinase
PG912_13210	COG3279	Response regulator of the LytR AlgR family
PG912_13225	COG0708	Exodeoxyribonuclease III
PG912_13240	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PG912_13245	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PG912_13250	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PG912_13260	COG1774	PSP1 C-terminal conserved region
PG912_13265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PG912_13285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PG912_13340	COG1028	Short-chain dehydrogenase reductase Sdr
PG912_13355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PG912_13365	COG2378	regulation of single-species biofilm formation
PG912_13390	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PG912_13395	COG3279	Response regulator of the LytR AlgR family
PG912_13400	COG2972	Histidine kinase
PG912_13415	COG3279	Response regulator of the LytR AlgR family
PG912_13420	COG2972	Histidine kinase
PG912_13425	COG0515	serine threonine protein kinase
PG912_13425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PG912_13440	COG2234	aminopeptidase activity
PG912_13445	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PG912_13455	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PG912_13455	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PG912_13470	COG1505	serine-type exopeptidase activity
PG912_13475	COG3590	peptidase
PG912_13505	COG4221	oxidoreductase activity
PG912_13525	COG3537	Alpha-1,2-mannosidase
PG912_13530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PG912_13550	COG1131	(ABC) transporter
PG912_13570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PG912_13595	COG0756	dUTP diphosphatase activity
PG912_13605	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PG912_13615	COG1187	pseudouridine synthase activity
PG912_13620	COG2153	protein acetylation
PG912_13625	COG0698	ribose 5-phosphate isomerase