locus-tag	class	description
H0I30_00045	COG2826	transposase and inactivated derivatives, IS30 family
H0I30_00055	COG0460	homoserine dehydrogenase
H0I30_00055	COG0527	aspartate kinase activity
H0I30_00065	COG1959	2 iron, 2 sulfur cluster binding
H0I30_00075	COG0175	sulfate reduction
H0I30_00080	COG0175	sulfate reduction
H0I30_00090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0I30_00095	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0I30_00105	COG1648	precorrin-2 dehydrogenase activity
H0I30_00105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H0I30_00110	COG0492	ferredoxin-NADP+ reductase activity
H0I30_00115	COG0633	Ferredoxin
H0I30_00120	COG1045	serine acetyltransferase
H0I30_00130	COG0646	methionine synthase
H0I30_00130	COG1410	methionine synthase
H0I30_00140	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H0I30_00145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0I30_00155	COG0076	glutamate decarboxylase activity
H0I30_00165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0I30_00175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0I30_00200	COG0360	Binds together with S18 to 16S ribosomal RNA
H0I30_00205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H0I30_00210	COG0359	binds to the 23S rRNA
H0I30_00215	COG0019	diaminopimelate decarboxylase activity
H0I30_00220	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0I30_00245	COG3959	Transketolase, thiamine diphosphate binding domain
H0I30_00250	COG0438	transferase activity, transferring glycosyl groups
H0I30_00285	COG0783	Belongs to the Dps family
H0I30_00295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H0I30_00310	COG1217	gtp-binding protein TYPA
H0I30_00315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0I30_00320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0I30_00325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0I30_00330	COG0131	Imidazoleglycerol-phosphate dehydratase
H0I30_00340	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H0I30_00345	COG0107	imidazoleglycerol-phosphate synthase activity
H0I30_00350	COG0140	phosphoribosyl-ATP diphosphatase activity
H0I30_00350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0I30_00355	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H0I30_00365	COG0697	spore germination
H0I30_00390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H0I30_00395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0I30_00400	COG2176	DNA-directed DNA polymerase activity
H0I30_00405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H0I30_00415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0I30_00420	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H0I30_00430	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0I30_00435	COG1629	transport
H0I30_00435	COG4206	TonB-dependent receptor
H0I30_00440	COG0012	GTP binding
H0I30_00450	COG0534	Mate efflux family protein
H0I30_00465	COG2860	membrane
H0I30_00480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0I30_00480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H0I30_00485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0I30_00535	COG3340	Belongs to the peptidase S51 family
H0I30_00540	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H0I30_00545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0I30_00575	COG2270	Major facilitator Superfamily
H0I30_00580	COG0564	pseudouridine synthase activity
H0I30_00585	COG1022	Amp-dependent synthetase and ligase
H0I30_00590	COG1022	Amp-dependent synthetase and ligase
H0I30_00595	COG3012	SEC-C Motif Domain Protein
H0I30_00605	COG0784	Response regulator, receiver
H0I30_00615	COG4251	negative regulation of phosphorylation
H0I30_00625	COG4251	negative regulation of phosphorylation
H0I30_00635	COG3279	Response regulator of the LytR AlgR family
H0I30_00680	COG0745	RESPONSE REGULATOR receiver
H0I30_00690	COG1482	cell wall glycoprotein biosynthetic process
H0I30_00695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0I30_00735	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0I30_00745	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H0I30_00755	COG2340	Cysteine-rich secretory protein family
H0I30_00775	COG2373	Large extracellular alpha-helical protein
H0I30_00865	COG2197	response regulator
H0I30_00870	COG0513	Belongs to the DEAD box helicase family
H0I30_00880	COG4953	penicillin-binding protein 1C
H0I30_00895	COG3263	regulation of cellular component size
H0I30_00900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0I30_00905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0I30_00925	COG0861	Integral membrane protein TerC family
H0I30_00940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0I30_00945	COG2346	COG2346, Truncated hemoglobins
H0I30_00965	COG1607	acyl-coa hydrolase
H0I30_00995	COG0488	(ABC) transporter
H0I30_01030	COG1363	Peptidase, m42
H0I30_01060	COG0167	dihydroorotate dehydrogenase activity
H0I30_01075	COG2318	DinB family
H0I30_01085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H0I30_01090	COG0564	pseudouridine synthase activity
H0I30_01110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H0I30_01145	COG3813	Protein conserved in bacteria
H0I30_01155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0I30_01160	COG2890	protein-(glutamine-N5) methyltransferase activity
H0I30_01175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0I30_01175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0I30_01180	COG1011	Hydrolase
H0I30_01185	COG0697	spore germination
H0I30_01190	COG1739	Uncharacterized protein family UPF0029
H0I30_01210	COG0539	negative regulation of cytoplasmic translation
H0I30_01220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0I30_01235	COG1522	sequence-specific DNA binding
H0I30_01245	COG0564	pseudouridine synthase activity
H0I30_01250	COG2814	Major facilitator Superfamily
H0I30_01260	COG0300	oxidoreductase activity
H0I30_01280	COG2207	Transcriptional regulator
H0I30_01285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0I30_01290	COG3938	Belongs to the proline racemase family
H0I30_01315	COG2095	MarC family integral membrane protein
H0I30_01335	COG0668	transmembrane transport
H0I30_01345	COG1064	alcohol dehydrogenase
H0I30_01350	COG1764	response to oxidative stress
H0I30_01355	COG1902	pentaerythritol trinitrate reductase activity
H0I30_01370	COG1309	transcriptional regulator
H0I30_01385	COG1979	alcohol dehydrogenase
H0I30_01400	COG1278	Cold shock
H0I30_01425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H0I30_01445	COG0542	response to heat
H0I30_01455	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H0I30_01465	COG0424	maF-like protein
H0I30_01470	COG3958	Transketolase
H0I30_01485	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H0I30_01490	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H0I30_01495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H0I30_01515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0I30_01515	COG0047	phosphoribosylformylglycinamidine synthase activity
H0I30_01540	COG1136	(ABC) transporter
H0I30_01540	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0I30_01550	COG2204	response regulator
H0I30_01555	COG4191	Histidine kinase
H0I30_01565	COG1028	Short-chain dehydrogenase reductase Sdr
H0I30_01570	COG0612	Peptidase, M16
H0I30_01575	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H0I30_01585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0I30_01590	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0I30_01595	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H0I30_01595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0I30_01600	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0I30_01605	COG1078	dGTPase activity
H0I30_01610	COG2204	response regulator
H0I30_01615	COG0802	atpase or kinase
H0I30_01620	COG0686	Belongs to the AlaDH PNT family
H0I30_01635	COG0514	ATP-dependent DNA helicase (RecQ)
H0I30_01645	COG0805	protein transport
H0I30_01655	COG1137	ATPase activity
H0I30_01660	COG1183	phosphatidylcholine synthase activity
H0I30_01675	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H0I30_01685	COG4974	Belongs to the 'phage' integrase family
H0I30_01700	COG0463	Glycosyl transferase, family 2
H0I30_01705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0I30_01710	COG1132	(ABC) transporter
H0I30_01715	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H0I30_01715	COG0617	tRNA 3'-terminal CCA addition
H0I30_01715	COG0517	IMP dehydrogenase activity
H0I30_01720	COG0009	L-threonylcarbamoyladenylate synthase
H0I30_01725	COG0438	transferase activity, transferring glycosyl groups
H0I30_01730	COG1086	Polysaccharide biosynthesis protein
H0I30_01740	COG1083	cytidylyl-transferase
H0I30_01750	COG2089	acid synthase
H0I30_01760	COG2171	N-acyltransferase activity
H0I30_01765	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0I30_01770	COG0242	peptide deformylase activity
H0I30_01780	COG3956	TIGRFAM MazG family protein
H0I30_01785	COG1028	Short-chain dehydrogenase reductase Sdr
H0I30_01790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0I30_01805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I30_01810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H0I30_01820	COG1136	(ABC) transporter
H0I30_01820	COG0577	efflux transmembrane transporter activity
H0I30_01825	COG1136	(ABC) transporter
H0I30_01825	COG0577	efflux transmembrane transporter activity
H0I30_01830	COG1136	(ABC) transporter
H0I30_01835	COG3011	Protein conserved in bacteria
H0I30_01840	COG4206	TonB-dependent receptor
H0I30_01935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0I30_01955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H0I30_01970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0I30_01985	COG0484	heat shock protein binding
H0I30_01990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H0I30_02000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H0I30_02010	COG0210	DNA helicase
H0I30_02035	COG2897	thiosulfate sulfurtransferase activity
H0I30_02040	COG1301	dicarboxylic acid transport
H0I30_02060	COG0668	transmembrane transport
H0I30_02075	COG0516	GMP reductase activity
H0I30_02075	COG0517	IMP dehydrogenase activity
H0I30_02100	COG1730	sister chromatid segregation
H0I30_02120	COG1595	DNA-templated transcription, initiation
H0I30_02145	COG0525	valine-tRNA ligase activity
H0I30_02160	COG0436	Aminotransferase
H0I30_02165	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H0I30_02185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0I30_02200	COG3876	Protein conserved in bacteria
H0I30_02230	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H0I30_02250	COG0714	Associated with various cellular activities
H0I30_02280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0I30_02280	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
H0I30_02285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0I30_02300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H0I30_02330	COG0813	purine-nucleoside phosphorylase activity
H0I30_02345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H0I30_02350	COG0673	inositol 2-dehydrogenase activity
H0I30_02355	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0I30_02365	COG0714	Associated with various cellular activities
H0I30_02370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0I30_02380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0I30_02395	COG0514	ATP-dependent DNA helicase (RecQ)
H0I30_02400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H0I30_02405	COG0776	regulation of translation
H0I30_02425	COG0116	Belongs to the methyltransferase superfamily
H0I30_02440	COG0662	Cupin 2, conserved barrel domain protein
H0I30_02440	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H0I30_02450	COG0433	COG0433 Predicted ATPase
H0I30_02455	COG0602	queuosine metabolic process
H0I30_02465	COG0825	malonyl-CoA metabolic process
H0I30_02480	COG0343	queuine tRNA-ribosyltransferase activity
H0I30_02485	COG1187	pseudouridine synthase activity
H0I30_02510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H0I30_02520	COG0564	pseudouridine synthase activity
H0I30_02530	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0I30_02535	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H0I30_02545	COG1595	DNA-templated transcription, initiation
H0I30_02570	COG1607	acyl-coa hydrolase
H0I30_02600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H0I30_02605	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H0I30_02610	COG0504	CTP synthase activity
H0I30_02615	COG0706	membrane insertase activity
H0I30_02620	COG1446	asparaginase
H0I30_02645	COG0590	tRNA wobble adenosine to inosine editing
H0I30_02655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H0I30_02660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H0I30_02665	COG0215	cysteine-tRNA ligase activity
H0I30_02680	COG1595	DNA-templated transcription, initiation
H0I30_02690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0I30_02690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0I30_02700	COG1228	amidohydrolase
H0I30_02710	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H0I30_02715	COG3279	Response regulator of the LytR AlgR family
H0I30_02740	COG3275	phosphorelay sensor kinase activity
H0I30_02770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H0I30_02775	COG1393	Belongs to the ArsC family
H0I30_02790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H0I30_02800	COG0497	DNA recombination
H0I30_02825	COG1528	Iron-storage protein
H0I30_02830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0I30_02865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0I30_02885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0I30_02890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H0I30_02900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0I30_02930	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H0I30_02935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0I30_02940	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0I30_02960	COG0653	protein targeting
H0I30_02965	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H0I30_02995	COG0534	Mate efflux family protein
H0I30_03000	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H0I30_03010	COG1674	ftsk spoiiie
H0I30_03025	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0I30_03025	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0I30_03040	COG0482	sulfurtransferase activity
H0I30_03070	COG0018	arginyl-trna synthetase
H0I30_03075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0I30_03090	COG0488	(ABC) transporter
H0I30_03100	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0I30_03105	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0I30_03105	COG1902	pentaerythritol trinitrate reductase activity
H0I30_03110	COG1741	Belongs to the pirin family
H0I30_03155	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H0I30_03165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0I30_03175	COG0217	transcriptional regulatory protein
H0I30_03185	COG1266	CAAX protease self-immunity
H0I30_03190	COG4948	Mandelate Racemase Muconate Lactonizing
H0I30_03200	COG1575	Belongs to the MenA family. Type 1 subfamily
H0I30_03205	COG0247	lactate metabolic process
H0I30_03205	COG2181	nitrate reductase activity
H0I30_03210	COG0247	lactate metabolic process
H0I30_03210	COG2181	nitrate reductase activity
H0I30_03220	COG0860	N-Acetylmuramoyl-L-alanine amidase
H0I30_03230	COG0251	oxidation-reduction process
H0I30_03250	COG0205	6-phosphofructokinase activity
H0I30_03270	COG1760	l-serine dehydratase
H0I30_03275	COG2949	membrane
H0I30_03280	COG3022	response to hydroperoxide
H0I30_03285	COG0321	lipoyl(octanoyl) transferase activity
H0I30_03285	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H0I30_03295	COG1595	DNA-templated transcription, initiation
H0I30_03335	COG1482	cell wall glycoprotein biosynthetic process
H0I30_03345	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H0I30_03350	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H0I30_03360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0I30_03380	COG3547	Transposase (IS116 IS110 IS902 family)
H0I30_03400	COG1104	cysteine desulfurase activity
H0I30_03430	COG0592	DNA-directed DNA polymerase activity
H0I30_03435	COG1192	Involved in chromosome partitioning
H0I30_03440	COG1475	DNA binding
H0I30_03450	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H0I30_03455	COG0681	Belongs to the peptidase S26 family
H0I30_03520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0I30_03545	COG1472	Belongs to the glycosyl hydrolase 3 family
H0I30_03560	COG2326	polyphosphate kinase activity
H0I30_03565	COG0655	NAD(P)H dehydrogenase (quinone) activity
H0I30_03590	COG1252	NADH dehydrogenase
H0I30_03605	COG3279	Response regulator of the LytR AlgR family
H0I30_03610	COG3275	phosphorelay sensor kinase activity
H0I30_03615	COG0443	Heat shock 70 kDa protein
H0I30_03625	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H0I30_03640	COG0799	negative regulation of ribosome biogenesis
H0I30_03645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0I30_03655	COG4589	Belongs to the CDS family
H0I30_03675	COG3104	oligopeptide transport
H0I30_03685	COG2274	protein secretion by the type I secretion system
H0I30_03715	COG1028	Short-chain dehydrogenase reductase Sdr
H0I30_03745	COG2827	Endonuclease containing a URI domain
H0I30_03750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0I30_03755	COG3844	kynureninase activity
H0I30_03760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0I30_03770	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H0I30_03770	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H0I30_03780	COG2813	Specifically methylates the guanine in position
H0I30_03785	COG0069	glutamate synthase activity
H0I30_03790	COG0254	rRNA binding
H0I30_03805	COG0402	S-adenosylhomocysteine deaminase activity
H0I30_03820	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H0I30_03820	COG0662	Cupin 2, conserved barrel domain protein
H0I30_03830	COG1663	tetraacyldisaccharide 4'-kinase activity
H0I30_03835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0I30_03850	COG0189	ligase activity
H0I30_03860	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H0I30_03880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H0I30_03885	COG0488	(ABC) transporter
H0I30_03920	COG1846	Transcriptional regulator
H0I30_03930	COG2076	Multidrug Resistance protein
H0I30_03945	COG0628	permease
H0I30_03995	COG2095	MarC family integral membrane protein
H0I30_04030	COG0009	L-threonylcarbamoyladenylate synthase
H0I30_04040	COG2050	protein possibly involved in aromatic compounds catabolism
H0I30_04050	COG1169	isochorismate synthase
H0I30_04060	COG1132	(ABC) transporter
H0I30_04070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0I30_04080	COG1862	Preprotein translocase
H0I30_04090	COG0237	dephospho-CoA kinase activity
H0I30_04105	COG1131	(ABC) transporter
H0I30_04140	COG0556	nucleotide-excision repair
H0I30_04160	COG0045	succinate-CoA ligase (ADP-forming) activity
H0I30_04170	COG1136	(ABC) transporter
H0I30_04185	COG3275	phosphorelay sensor kinase activity
H0I30_04190	COG3279	Response regulator of the LytR AlgR family
H0I30_04215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0I30_04225	COG0552	protein localization to endoplasmic reticulum
H0I30_04235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H0I30_04240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H0I30_04245	COG1058	Belongs to the CinA family
H0I30_04245	COG1546	Belongs to the CinA family
H0I30_04250	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0I30_04265	COG2996	Protein conserved in bacteria
H0I30_04270	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H0I30_04275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0I30_04280	COG0300	oxidoreductase activity
H0I30_04290	COG5383	Protein conserved in bacteria
H0I30_04305	COG0247	lactate metabolic process
H0I30_04305	COG0277	FAD linked oxidase domain protein
H0I30_04325	COG2072	flavoprotein involved in K transport
H0I30_04335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I30_04360	COG1073	alpha beta
H0I30_04395	COG0589	response to stress
H0I30_04410	COG0348	domain, Protein
H0I30_04435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0I30_04440	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H0I30_04465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H0I30_04470	COG0085	RNA polymerase activity
H0I30_04475	COG0222	ribosome binding
H0I30_04480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0I30_04485	COG0081	regulation of translation
H0I30_04490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H0I30_04510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0I30_04545	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H0I30_04550	COG1960	acyl-CoA dehydrogenase activity
H0I30_04560	COG1115	amino acid carrier protein
H0I30_04580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0I30_04585	COG1611	Belongs to the LOG family
H0I30_04610	COG0778	Nitroreductase
H0I30_04615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0I30_04635	COG0450	alkyl hydroperoxide reductase
H0I30_04670	COG3264	Mechanosensitive ion channel
H0I30_04670	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H0I30_04675	COG1668	transmembrane transport
H0I30_04680	COG4152	abc transporter atp-binding protein
H0I30_04690	COG1024	Enoyl-CoA hydratase
H0I30_04690	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0I30_04695	COG0183	Belongs to the thiolase family
H0I30_04700	COG1960	acyl-CoA dehydrogenase activity
H0I30_04710	COG4106	trans-aconitate 2-methyltransferase activity
H0I30_04725	COG0492	ferredoxin-NADP+ reductase activity
H0I30_04735	COG4974	Belongs to the 'phage' integrase family
H0I30_04745	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0I30_04760	COG2132	Multicopper oxidase
H0I30_04805	COG2217	Heavy metal translocating P-type atpase
H0I30_04825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0I30_04850	COG0347	Belongs to the P(II) protein family
H0I30_04865	COG2217	Heavy metal translocating P-type atpase
H0I30_04940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0I30_04955	COG2197	response regulator
H0I30_04965	COG4585	Histidine kinase
H0I30_04975	COG0101	tRNA pseudouridine synthase activity
H0I30_04980	COG1132	(ABC) transporter
H0I30_04990	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H0I30_04995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0I30_05010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H0I30_05045	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0I30_05050	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0I30_05050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0I30_05055	COG0688	phosphatidylethanolamine metabolic process
H0I30_05060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H0I30_05060	COG1333	cytochrome c biogenesis protein
H0I30_05075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0I30_05080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0I30_05090	COG0295	cytidine deaminase activity
H0I30_05095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0I30_05100	COG0519	Catalyzes the synthesis of GMP from XMP
H0I30_05100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0I30_05120	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H0I30_05130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0I30_05135	COG1215	transferase activity, transferring glycosyl groups
H0I30_05185	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H0I30_05195	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H0I30_05230	COG0848	biopolymer transport protein
H0I30_05235	COG0811	peptide transport
H0I30_05250	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H0I30_05255	COG1960	acyl-CoA dehydrogenase activity
H0I30_05345	COG0156	8-amino-7-oxononanoate synthase activity
H0I30_05360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0I30_05370	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H0I30_05380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H0I30_05385	COG0737	Belongs to the 5'-nucleotidase family
H0I30_05395	COG1702	phosphate starvation-inducible protein PhoH
H0I30_05430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H0I30_05460	COG1132	(ABC) transporter
H0I30_05480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0I30_05495	COG4191	Histidine kinase
H0I30_05510	COG1858	cytochrome C peroxidase
H0I30_05520	COG0783	Belongs to the Dps family
H0I30_05530	COG0659	secondary active sulfate transmembrane transporter activity
H0I30_05535	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H0I30_05540	COG0540	Belongs to the ATCase OTCase family
H0I30_05555	COG1234	tRNA 3'-trailer cleavage
H0I30_05565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0I30_05570	COG0326	Molecular chaperone. Has ATPase activity
H0I30_05575	COG4628	conserved protein (DUF2132)
H0I30_05645	COG1090	epimerase
H0I30_05660	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0I30_05670	COG0408	coproporphyrinogen oxidase activity
H0I30_05685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H0I30_05695	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H0I30_05700	COG0113	porphobilinogen synthase activity
H0I30_05710	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H0I30_05725	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H0I30_05730	COG1981	membrane
H0I30_05735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0I30_05740	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0I30_05745	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H0I30_05750	COG0405	Gamma-glutamyltransferase
H0I30_05765	COG0336	Belongs to the RNA methyltransferase TrmD family
H0I30_05770	COG0463	Glycosyl transferase, family 2
H0I30_05775	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H0I30_05780	COG0335	large ribosomal subunit rRNA binding
H0I30_05790	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H0I30_05835	COG1418	mRNA catabolic process
H0I30_05900	COG3177	Filamentation induced by cAMP protein fic
H0I30_05950	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H0I30_06065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0I30_06070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0I30_06220	COG2732	(Barnase) inhibitor
H0I30_06240	COG3547	Transposase (IS116 IS110 IS902 family)
H0I30_06260	COG1902	pentaerythritol trinitrate reductase activity
H0I30_06265	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H0I30_06270	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H0I30_06285	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H0I30_06300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0I30_06305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0I30_06310	COG1595	DNA-templated transcription, initiation
H0I30_06315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0I30_06330	COG4771	TonB-dependent receptor
H0I30_06365	COG3275	phosphorelay sensor kinase activity
H0I30_06370	COG3279	Response regulator of the LytR AlgR family
H0I30_06375	COG1678	Uncharacterized ACR, COG1678
H0I30_06400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0I30_06440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H0I30_06445	COG0626	cystathionine gamma-synthase activity
H0I30_06490	COG0183	Belongs to the thiolase family
H0I30_06495	COG0791	NLP P60 protein
H0I30_06510	COG0542	response to heat
H0I30_06515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I30_06520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I30_06580	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H0I30_06590	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H0I30_06600	COG0671	phosphoesterase, PA-phosphatase related
H0I30_06605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0I30_06620	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H0I30_06625	COG0105	UTP biosynthetic process
H0I30_06635	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H0I30_06645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H0I30_06655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0I30_06680	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H0I30_06690	COG3608	succinylglutamate desuccinylase aspartoacylase
H0I30_06690	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H0I30_06695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H0I30_06705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0I30_06730	COG0259	pyridoxamine-phosphate oxidase activity
H0I30_06785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0I30_06815	COG4166	transmembrane transport
H0I30_06825	COG2329	Antibiotic biosynthesis monooxygenase
H0I30_06835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0I30_06855	COG4895	conserved protein (DUF2196)
H0I30_06860	COG1278	Cold shock
H0I30_06865	COG1278	Cold shock
H0I30_06870	COG1278	Cold shock
H0I30_06885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0I30_06900	COG0302	gtp cyclohydrolase
H0I30_06905	COG0124	histidyl-tRNA synthetase
H0I30_06910	COG1295	ribonuclease BN
H0I30_06920	COG0339	signal peptide processing
H0I30_06930	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H0I30_06945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H0I30_06950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0I30_06955	COG1120	ATPase activity
H0I30_06960	COG2234	aminopeptidase activity
H0I30_06970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H0I30_06975	COG2022	thiamine diphosphate biosynthetic process
H0I30_06980	COG0352	thiamine-phosphate diphosphorylase activity
H0I30_06995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H0I30_07010	COG0010	Belongs to the arginase family
H0I30_07025	COG0148	phosphopyruvate hydratase activity
H0I30_07030	COG0505	Belongs to the CarA family
H0I30_07035	COG0203	ribosomal protein L17
H0I30_07040	COG0202	RNA polymerase activity
H0I30_07045	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H0I30_07050	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H0I30_07055	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H0I30_07060	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H0I30_07065	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H0I30_07075	COG0200	Binds to the 23S rRNA
H0I30_07080	COG1841	ribosomal large subunit assembly
H0I30_07085	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H0I30_07090	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H0I30_07095	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H0I30_07100	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H0I30_07105	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H0I30_07110	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H0I30_07115	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H0I30_07120	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H0I30_07125	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H0I30_07130	COG0255	Belongs to the universal ribosomal protein uL29 family
H0I30_07135	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H0I30_07140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H0I30_07145	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H0I30_07150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H0I30_07155	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H0I30_07160	COG0089	rRNA binding
H0I30_07165	COG0088	Forms part of the polypeptide exit tunnel
H0I30_07170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H0I30_07175	COG0051	transcription antitermination factor activity, RNA binding
H0I30_07180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H0I30_07185	COG0049	tRNA binding
H0I30_07190	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H0I30_07195	COG1629	transport
H0I30_07195	COG4206	TonB-dependent receptor
H0I30_07205	COG1629	transport
H0I30_07220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0I30_07230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0I30_07240	COG1011	Hydrolase
H0I30_07250	COG2003	Belongs to the UPF0758 family
H0I30_07255	COG0569	domain protein
H0I30_07260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0I30_07295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0I30_07300	COG1629	transport
H0I30_07315	COG1404	Belongs to the peptidase S8 family
H0I30_07335	COG3530	Putative quorum-sensing-regulated virulence factor
H0I30_07410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H0I30_07435	COG1459	type II secretion system
H0I30_07475	COG1166	arginine decarboxylase activity
H0I30_07480	COG0010	Belongs to the arginase family
H0I30_07485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0I30_07485	COG3153	acetyltransferase
H0I30_07490	COG1899	peptidyl-lysine modification to peptidyl-hypusine
H0I30_07500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0I30_07505	COG1129	ABC transporter
H0I30_07535	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H0I30_07570	COG0174	glutamine synthetase
H0I30_07600	COG2885	chlorophyll binding
H0I30_07625	COG2264	protein methyltransferase activity
H0I30_07630	COG0149	triose-phosphate isomerase activity
H0I30_07640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I30_07650	COG0601	transmembrane transport
H0I30_07655	COG0284	orotidine-5'-phosphate decarboxylase activity
H0I30_07660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H0I30_07685	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H0I30_07690	COG2986	histidine ammonia-lyase
H0I30_07695	COG0583	DNA-binding transcription factor activity
H0I30_07705	COG1703	isobutyryl-CoA mutase activity
H0I30_07705	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0I30_07705	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0I30_07745	COG0514	ATP-dependent DNA helicase (RecQ)
H0I30_07750	COG4946	Tricorn protease homolog
H0I30_07750	COG0793	Belongs to the peptidase S41A family
H0I30_07755	COG1629	transport
H0I30_07760	COG1047	Peptidyl-prolyl cis-trans
H0I30_07765	COG0159	tryptophan synthase activity
H0I30_07770	COG0133	tryptophan synthase activity
H0I30_07775	COG0135	phosphoribosylanthranilate isomerase activity
H0I30_07780	COG0134	indole-3-glycerol-phosphate synthase activity
H0I30_07785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0I30_07790	COG0512	Glutamine amidotransferase of anthranilate synthase
H0I30_07795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0I30_07805	COG0367	asparagine synthase
H0I30_07810	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H0I30_07820	COG0187	DNA topoisomerase II activity
H0I30_07835	COG0039	L-malate dehydrogenase activity
H0I30_07840	COG2884	Cell division ATP-binding protein ftsE
H0I30_07865	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H0I30_07870	COG0545	Peptidyl-prolyl cis-trans isomerase
H0I30_07875	COG1595	DNA-templated transcription, initiation
H0I30_07885	COG1032	radical SAM domain protein
H0I30_07900	COG2072	flavoprotein involved in K transport
H0I30_07910	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H0I30_07915	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H0I30_07955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0I30_07965	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H0I30_07970	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H0I30_07975	COG0339	signal peptide processing
H0I30_07985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0I30_07995	COG1253	flavin adenine dinucleotide binding
H0I30_08020	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H0I30_08045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0I30_08050	COG3279	Response regulator of the LytR AlgR family
H0I30_08055	COG3275	phosphorelay sensor kinase activity
H0I30_08065	COG1705	Flagellar rod assembly protein muramidase FlgJ
H0I30_08065	COG3942	CHAP domain
H0I30_08075	COG0488	(ABC) transporter
H0I30_08105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0I30_08120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0I30_08125	COG3604	Transcriptional regulator
H0I30_08145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H0I30_08150	COG0459	protein refolding
H0I30_08170	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H0I30_08175	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H0I30_08200	COG2814	Major facilitator Superfamily
H0I30_08210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0I30_08215	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H0I30_08220	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H0I30_08225	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H0I30_08230	COG2363	Small membrane protein
H0I30_08245	COG0596	Alpha beta hydrolase
H0I30_08250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H0I30_08255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0I30_08255	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H0I30_08265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0I30_08295	COG0519	Catalyzes the synthesis of GMP from XMP
H0I30_08305	COG0616	signal peptide processing
H0I30_08310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0I30_08335	COG0612	Peptidase, M16
H0I30_08345	COG0436	Aminotransferase
H0I30_08355	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H0I30_08360	COG1162	GTPase activity
H0I30_08365	COG1490	D-aminoacyl-tRNA deacylase activity
H0I30_08375	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H0I30_08385	COG0321	lipoyl(octanoyl) transferase activity
H0I30_08425	COG1428	Deoxynucleoside kinase
H0I30_08430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0I30_08440	COG0191	fructose-bisphosphate aldolase activity
H0I30_08445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H0I30_08450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H0I30_08455	COG1185	polyribonucleotide nucleotidyltransferase activity
H0I30_08460	COG1428	Deoxynucleoside kinase
H0I30_08475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0I30_08480	COG0358	DNA primase activity
H0I30_08490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H0I30_08500	COG0544	peptidyl-prolyl cis-trans isomerase activity
H0I30_08505	COG1950	PFAM Membrane protein of
H0I30_08515	COG0101	tRNA pseudouridine synthase activity
H0I30_08520	COG2267	carboxylic ester hydrolase activity
H0I30_08525	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0I30_08535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0I30_08545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0I30_08565	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0I30_08610	COG0415	Belongs to the DNA photolyase family
H0I30_08620	COG3046	protein related to deoxyribodipyrimidine photolyase
H0I30_08630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0I30_08640	COG1160	GTP binding
H0I30_08660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0I30_08675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0I30_08685	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H0I30_08705	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H0I30_08720	COG2363	Small membrane protein
H0I30_08740	COG1704	LemA family
H0I30_08755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H0I30_08765	COG2314	TM2 domain
H0I30_08770	COG0415	Belongs to the DNA photolyase family
H0I30_08780	COG0386	Belongs to the glutathione peroxidase family
H0I30_08790	COG0300	oxidoreductase activity
H0I30_08795	COG0702	epimerase
H0I30_08805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0I30_08815	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H0I30_08855	COG3186	Phenylalanine-4-hydroxylase
H0I30_08860	COG0501	Belongs to the peptidase M48B family
H0I30_08875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0I30_08895	COG2226	methyltransferase
H0I30_08900	COG1477	protein flavinylation
H0I30_08910	COG1368	sulfuric ester hydrolase activity
H0I30_08915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0I30_08920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0I30_08925	COG0052	Belongs to the universal ribosomal protein uS2 family
H0I30_08930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H0I30_08935	COG0528	UMP kinase activity
H0I30_08940	COG0233	cytoplasmic translational termination
H0I30_08950	COG0017	Asparaginyl-tRNA synthetase
H0I30_08985	COG0811	peptide transport
H0I30_08990	COG0252	asparaginase activity
H0I30_09000	COG0481	GTPase activity
H0I30_09005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0I30_09010	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0I30_09015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H0I30_09025	COG4585	Histidine kinase
H0I30_09040	COG0346	lactoylglutathione lyase activity
H0I30_09045	COG2177	Part of the ABC transporter FtsEX involved in
H0I30_09055	COG1968	undecaprenyl-diphosphatase activity
H0I30_09060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0I30_09075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0I30_09085	COG2137	regulation of response to DNA damage stimulus
H0I30_09095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0I30_09105	COG1309	transcriptional regulator
H0I30_09125	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0I30_09135	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H0I30_09140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0I30_09145	COG0511	ligase activity, forming carbon-carbon bonds
H0I30_09150	COG0439	Biotin carboxylase
H0I30_09175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H0I30_09190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0I30_09195	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H0I30_09210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0I30_09215	COG3655	Transcriptional regulator
H0I30_09235	COG1522	sequence-specific DNA binding
H0I30_09250	COG3409	Peptidoglycan-binding domain 1 protein
H0I30_09250	COG0793	Belongs to the peptidase S41A family
H0I30_09255	COG2258	MOSC domain
H0I30_09265	COG5002	protein histidine kinase activity
H0I30_09280	COG0739	heme binding
H0I30_09285	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H0I30_09290	COG0194	GDP metabolic process
H0I30_09295	COG1561	YicC-like family, N-terminal region
H0I30_09305	COG1652	LysM domain
H0I30_09310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0I30_09330	COG1858	cytochrome C peroxidase
H0I30_09340	COG0719	Fe-S assembly protein
H0I30_09350	COG0396	ATPase activity
H0I30_09355	COG0719	Fe-S assembly protein
H0I30_09365	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0I30_09415	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H0I30_09425	COG0156	8-amino-7-oxononanoate synthase activity
H0I30_09435	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H0I30_09445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H0I30_09465	COG2268	Band 7 protein
H0I30_09470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H0I30_09490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0I30_09495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H0I30_09510	COG1595	DNA-templated transcription, initiation
H0I30_09520	COG4122	O-methyltransferase activity
H0I30_09525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H0I30_09530	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H0I30_09535	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H0I30_09545	COG0156	8-amino-7-oxononanoate synthase activity
H0I30_09550	COG1074	ATP-dependent DNA helicase activity
H0I30_09555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0I30_09560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0I30_09570	COG1121	(ABC) transporter
H0I30_09575	COG0803	Belongs to the bacterial solute-binding protein 9 family
H0I30_09585	COG4771	TonB-dependent receptor
H0I30_09605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H0I30_09610	COG0195	Participates in both transcription termination and antitermination
H0I30_09610	COG2251	uridine kinase activity
H0I30_09615	COG0779	Required for maturation of 30S ribosomal subunits
H0I30_09630	COG1435	thymidine kinase activity
H0I30_09635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0I30_09640	COG1970	mechanosensitive ion channel activity
H0I30_09655	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0I30_09655	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H0I30_09695	COG1946	Acyl-CoA thioesterase
H0I30_09710	COG0495	leucyl-tRNA aminoacylation
H0I30_09730	COG4771	TonB-dependent receptor
H0I30_09745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0I30_09760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H0I30_09765	COG0463	Glycosyl transferase, family 2
H0I30_09780	COG0306	phosphate transporter
H0I30_09795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0I30_09805	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H0I30_09825	COG1215	transferase activity, transferring glycosyl groups
H0I30_09855	COG0509	glycine decarboxylation via glycine cleavage system
H0I30_09865	COG0632	four-way junction helicase activity
H0I30_09870	COG0280	phosphate acetyltransferase
H0I30_09870	COG0281	malic enzyme
H0I30_09875	COG0840	transmembrane signaling receptor activity
H0I30_09930	COG4206	TonB-dependent receptor
H0I30_09935	COG1381	Involved in DNA repair and RecF pathway recombination
H0I30_09940	COG2954	triphosphatase activity
H0I30_09945	COG1272	protein, Hemolysin III
H0I30_09965	COG0667	Aldo Keto reductase
H0I30_09970	COG0126	phosphoglycerate kinase activity
H0I30_09975	COG0314	molybdopterin synthase activity
H0I30_09985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0I30_10010	COG4206	TonB-dependent receptor
H0I30_10010	COG1629	transport
H0I30_10015	COG0166	Belongs to the GPI family
H0I30_10030	COG3483	tryptophan 2,3-dioxygenase activity
H0I30_10035	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H0I30_10045	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H0I30_10060	COG0492	ferredoxin-NADP+ reductase activity
H0I30_10070	COG0489	protein tyrosine kinase activity
H0I30_10080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0I30_10095	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H0I30_10100	COG2267	carboxylic ester hydrolase activity
H0I30_10110	COG1114	Component of the transport system for branched-chain amino acids
H0I30_10130	COG0470	DNA polymerase III
H0I30_10140	COG5000	phosphorelay sensor kinase activity
H0I30_10145	COG1024	Enoyl-CoA hydratase
H0I30_10160	COG1418	mRNA catabolic process
H0I30_10165	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H0I30_10175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0I30_10185	COG3279	Response regulator of the LytR AlgR family
H0I30_10190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H0I30_10195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H0I30_10200	COG0612	Peptidase, M16
H0I30_10205	COG0612	Peptidase, M16
H0I30_10235	COG0629	single-stranded DNA binding
H0I30_10240	COG1194	a g-specific adenine glycosylase
H0I30_10245	COG0776	regulation of translation
H0I30_10250	COG1530	ribonuclease E activity
H0I30_10260	COG0322	excinuclease ABC activity
H0I30_10265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H0I30_10270	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H0I30_10280	COG0303	'Molybdopterin
H0I30_10285	COG2827	Endonuclease containing a URI domain
H0I30_10290	COG0315	cyclic pyranopterin monophosphate synthase activity
H0I30_10290	COG0746	molybdenum cofactor guanylyltransferase activity
H0I30_10295	COG0315	cyclic pyranopterin monophosphate synthase activity
H0I30_10295	COG0746	molybdenum cofactor guanylyltransferase activity
H0I30_10305	COG0189	ligase activity
H0I30_10305	COG4067	protein conserved in archaea
H0I30_10345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0I30_10350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H0I30_10355	COG0193	aminoacyl-tRNA hydrolase activity
H0I30_10360	COG0720	synthase
H0I30_10385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H0I30_10400	COG4585	Histidine kinase
H0I30_10410	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0I30_10430	COG0594	ribonuclease P activity
H0I30_10435	COG0793	Belongs to the peptidase S41A family
H0I30_10445	COG0151	Belongs to the GarS family
H0I30_10450	COG5002	protein histidine kinase activity
H0I30_10455	COG0745	RESPONSE REGULATOR receiver
H0I30_10465	COG0488	(ABC) transporter
H0I30_10475	COG5297	Belongs to the glycosyl hydrolase family 6
H0I30_10475	COG4733	cellulase activity
H0I30_10490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H0I30_10510	COG0628	permease
H0I30_10515	COG1607	acyl-coa hydrolase
H0I30_10525	COG0758	DNA mediated transformation
H0I30_10525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0I30_10540	COG0697	spore germination
H0I30_10545	COG1988	membrane-bound metal-dependent
H0I30_10550	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0I30_10555	COG0419	ATPase involved in DNA repair
H0I30_10560	COG0420	3'-5' exonuclease activity
H0I30_10575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0I30_10590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H0I30_10595	COG0445	tRNA wobble uridine modification
H0I30_10620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H0I30_10630	COG0557	exoribonuclease II activity
H0I30_10635	COG1597	lipid kinase activity
H0I30_10645	COG0698	ribose 5-phosphate isomerase
H0I30_10650	COG2153	protein acetylation
H0I30_10655	COG1187	pseudouridine synthase activity
H0I30_10665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H0I30_10675	COG1228	amidohydrolase
H0I30_10685	COG0756	dUTP diphosphatase activity
H0I30_10690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H0I30_10720	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H0I30_10735	COG1012	belongs to the aldehyde dehydrogenase family
H0I30_10745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0I30_10770	COG4221	oxidoreductase activity
H0I30_10805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0I30_10810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0I30_10815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0I30_10830	COG3842	ATPase activity
H0I30_10845	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H0I30_10875	COG0584	glycerophosphoryl diester phosphodiesterase
H0I30_10880	COG3590	peptidase
H0I30_10885	COG1505	serine-type exopeptidase activity
H0I30_10900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0I30_10900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H0I30_10915	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H0I30_10935	COG2095	MarC family integral membrane protein
H0I30_10945	COG2356	endonuclease I
H0I30_10950	COG3279	Response regulator of the LytR AlgR family
H0I30_10955	COG3275	phosphorelay sensor kinase activity
H0I30_10970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0I30_10975	COG1053	succinate dehydrogenase
H0I30_10985	COG1051	belongs to the nudix hydrolase family
H0I30_10990	COG0598	Magnesium transport protein CorA
H0I30_11020	COG0006	proline dipeptidase activity
H0I30_11030	COG0513	Belongs to the DEAD box helicase family
H0I30_11065	COG0189	ligase activity
H0I30_11090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0I30_11110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0I30_11115	COG1774	PSP1 C-terminal conserved region
H0I30_11125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H0I30_11130	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0I30_11135	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0I30_11150	COG0708	Exodeoxyribonuclease III
H0I30_11155	COG4932	domain protein
H0I30_11155	COG1388	LysM domain
H0I30_11200	COG0356	it plays a direct role in the translocation of protons across the membrane
H0I30_11205	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0I30_11210	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H0I30_11215	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0I30_11220	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H0I30_11225	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H0I30_11235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H0I30_11240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H0I30_11290	COG2239	Acts as a magnesium transporter
H0I30_11295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0I30_11315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H0I30_11320	COG0196	riboflavin kinase activity
H0I30_11325	COG1629	transport
H0I30_11335	COG0423	glycine-tRNA ligase activity
H0I30_11355	COG1040	competence protein
H0I30_11375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0I30_11375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0I30_11380	COG1408	metallophosphoesterase
H0I30_11415	COG0626	cystathionine gamma-synthase activity
H0I30_11425	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H0I30_11435	COG0460	homoserine dehydrogenase
H0I30_11435	COG0527	aspartate kinase activity
H0I30_11450	COG1999	signal sequence binding
H0I30_11465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H0I30_11480	COG1115	amino acid carrier protein
H0I30_11490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H0I30_11495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0I30_11505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0I30_11515	COG0297	glycogen (starch) synthase activity
H0I30_11520	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H0I30_11525	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H0I30_11535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H0I30_11545	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H0I30_11555	COG2226	methyltransferase
H0I30_11570	COG1054	Belongs to the UPF0176 family
H0I30_11605	COG0109	protoheme IX farnesyltransferase activity
H0I30_11610	COG1845	cytochrome c oxidase, subunit III
H0I30_11630	COG1999	signal sequence binding
H0I30_11635	COG2322	membrane
H0I30_11650	COG1214	PFAM Peptidase M22, glycoprotease
H0I30_11655	COG0668	transmembrane transport
H0I30_11660	COG3759	membrane
H0I30_11670	COG3341	Caulimovirus viroplasmin
H0I30_11670	COG0328	RNA-DNA hybrid ribonuclease activity
H0I30_11675	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H0I30_11680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0I30_11685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0I30_11690	COG0571	ribonuclease III activity
H0I30_11700	COG0469	pyruvate kinase activity
H0I30_11710	COG0517	IMP dehydrogenase activity
H0I30_11710	COG0516	GMP reductase activity
H0I30_11725	COG0629	single-stranded DNA binding
H0I30_11745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0I30_11745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0I30_11750	COG1619	proteins homologs of microcin C7 resistance protein MccF
H0I30_11755	COG0792	nuclease activity
H0I30_11765	COG1028	Short-chain dehydrogenase reductase Sdr
H0I30_11795	COG0288	reversible hydration of carbon dioxide
H0I30_11800	COG0659	secondary active sulfate transmembrane transporter activity
H0I30_11825	COG2304	oxidoreductase activity
H0I30_11830	COG2304	oxidoreductase activity
H0I30_11845	COG0714	Associated with various cellular activities
H0I30_11865	COG0084	hydrolase, TatD family'
H0I30_11880	COG0436	Aminotransferase
H0I30_11885	COG3239	Fatty acid desaturase
H0I30_11890	COG0357	Ribosomal RNA small subunit methyltransferase G
H0I30_11910	COG0513	Belongs to the DEAD box helicase family
H0I30_11925	COG0494	nUDIX hydrolase
H0I30_11930	COG2066	Belongs to the glutaminase family
H0I30_11940	COG1012	belongs to the aldehyde dehydrogenase family
H0I30_11955	COG2967	ApaG domain
H0I30_11965	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H0I30_11970	COG1805	sodium ion transport
H0I30_11975	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H0I30_11980	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H0I30_11985	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H0I30_11995	COG0513	Belongs to the DEAD box helicase family
H0I30_12005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0I30_12010	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H0I30_12025	COG1253	flavin adenine dinucleotide binding
H0I30_12045	COG2151	metal-sulfur cluster biosynthetic enzyme
H0I30_12050	COG2166	iron-sulfur cluster assembly
H0I30_12060	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H0I30_12070	COG3474	cytochrome
H0I30_12075	COG0437	4 iron, 4 sulfur cluster binding
H0I30_12105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0I30_12110	COG2255	four-way junction helicase activity
H0I30_12125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H0I30_12125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0I30_12150	COG1045	serine acetyltransferase
H0I30_12185	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H0I30_12190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0I30_12195	COG0606	chelatase, subunit chli
H0I30_12200	COG0785	Cytochrome C biogenesis protein
H0I30_12205	COG0037	tRNA processing
H0I30_12210	COG2267	carboxylic ester hydrolase activity
H0I30_12225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0I30_12230	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H0I30_12235	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0I30_12245	COG0022	dehydrogenase e1 component
H0I30_12245	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0I30_12250	COG2086	electron transfer activity
H0I30_12255	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H0I30_12265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H0I30_12270	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H0I30_12280	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H0I30_12305	COG1278	Cold shock
H0I30_12310	COG0228	four-way junction DNA binding
H0I30_12315	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0I30_12320	COG2824	Alkylphosphonate utilization operon protein PhnA
H0I30_12330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0I30_12350	COG1757	Na H antiporter
H0I30_12360	COG2095	MarC family integral membrane protein
H0I30_12420	COG0668	transmembrane transport
H0I30_12430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H0I30_12460	COG1012	belongs to the aldehyde dehydrogenase family
H0I30_12470	COG0564	pseudouridine synthase activity
H0I30_12475	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H0I30_12485	COG2001	Belongs to the MraZ family
H0I30_12490	COG0275	rRNA processing
H0I30_12500	COG0768	penicillin binding
H0I30_12505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0I30_12510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0I30_12515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H0I30_12520	COG0772	Belongs to the SEDS family
H0I30_12525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H0I30_12530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0I30_12535	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H0I30_12545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0I30_12550	COG1610	YqeY-like protein
H0I30_12565	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0I30_12570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0I30_12575	COG1595	DNA-templated transcription, initiation
H0I30_12600	COG2226	methyltransferase
H0I30_12605	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H0I30_12620	COG0442	prolyl-tRNA aminoacylation
H0I30_12635	COG0268	Binds directly to 16S ribosomal RNA
H0I30_12640	COG0772	Belongs to the SEDS family
H0I30_12645	COG0768	penicillin binding
H0I30_12660	COG1077	Cell shape determining protein MreB Mrl
H0I30_12665	COG0138	bifunctional purine biosynthesis protein purh
H0I30_12690	COG1187	pseudouridine synthase activity
H0I30_12715	COG3279	Response regulator of the LytR AlgR family
H0I30_12755	COG2081	HI0933 family
H0I30_12770	COG1506	peptidase
H0I30_12770	COG0823	Involved in the tonB-independent uptake of proteins
H0I30_12785	COG4232	protein-disulfide reductase activity
H0I30_12790	COG0658	competence protein
H0I30_12790	COG2333	competence protein COMEC
H0I30_12805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H0I30_12855	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H0I30_12865	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0I30_12870	COG0791	NLP P60 protein
H0I30_12880	COG0791	NLP P60 protein
H0I30_12890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H0I30_12895	COG0563	adenylate kinase activity
H0I30_12900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0I30_12905	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H0I30_12920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H0I30_12925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H0I30_12930	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H0I30_12935	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)