locus-tag	class	description
LPB136_00025	COG1595	DNA-templated transcription, initiation
LPB136_00030	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LPB136_00055	COG2884	Cell division ATP-binding protein ftsE
LPB136_00085	COG3530	Putative quorum-sensing-regulated virulence factor
LPB136_00100	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LPB136_00105	COG2885	chlorophyll binding
LPB136_00105	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LPB136_00110	COG2234	aminopeptidase activity
LPB136_00115	COG1404	Belongs to the peptidase S8 family
LPB136_00135	COG4206	TonB-dependent receptor
LPB136_00135	COG1629	transport
LPB136_00140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPB136_00155	COG0569	domain protein
LPB136_00160	COG2003	Belongs to the UPF0758 family
LPB136_00180	COG0438	transferase activity, transferring glycosyl groups
LPB136_00195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPB136_00205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LPB136_00220	COG4206	TonB-dependent receptor
LPB136_00220	COG1629	transport
LPB136_00230	COG4206	TonB-dependent receptor
LPB136_00230	COG1629	transport
LPB136_00245	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LPB136_00250	COG0049	tRNA binding
LPB136_00255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LPB136_00260	COG0051	transcription antitermination factor activity, RNA binding
LPB136_00265	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LPB136_00270	COG0088	Forms part of the polypeptide exit tunnel
LPB136_00275	COG0089	rRNA binding
LPB136_00280	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LPB136_00285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LPB136_00290	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LPB136_00295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LPB136_00300	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LPB136_00305	COG0255	Belongs to the universal ribosomal protein uL29 family
LPB136_00310	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LPB136_00315	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LPB136_00320	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LPB136_00325	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LPB136_00330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LPB136_00335	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LPB136_00340	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LPB136_00345	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LPB136_00350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LPB136_00355	COG1841	ribosomal large subunit assembly
LPB136_00360	COG0200	Binds to the 23S rRNA
LPB136_00365	COG0201	protein transport
LPB136_00370	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LPB136_00375	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LPB136_00380	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LPB136_00385	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LPB136_00390	COG0202	RNA polymerase activity
LPB136_00395	COG0203	ribosomal protein L17
LPB136_00400	COG0505	Belongs to the CarA family
LPB136_00405	COG0148	phosphopyruvate hydratase activity
LPB136_00425	COG2339	peptidase activity
LPB136_00455	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPB136_00480	COG0662	Cupin 2, conserved barrel domain protein
LPB136_00480	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LPB136_00500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LPB136_00515	COG0254	rRNA binding
LPB136_00520	COG0069	glutamate synthase activity
LPB136_00525	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPB136_00525	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPB136_00535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LPB136_00540	COG3844	kynureninase activity
LPB136_00545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPB136_00580	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_00585	COG1917	Cupin 2, conserved barrel domain protein
LPB136_00610	COG4589	Belongs to the CDS family
LPB136_00620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LPB136_00625	COG0799	negative regulation of ribosome biogenesis
LPB136_00630	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LPB136_00630	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LPB136_00640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LPB136_00645	COG1051	belongs to the nudix hydrolase family
LPB136_00650	COG0443	Heat shock 70 kDa protein
LPB136_00660	COG1252	NADH dehydrogenase
LPB136_00685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPB136_00695	COG3608	succinylglutamate desuccinylase aspartoacylase
LPB136_00695	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LPB136_00705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LPB136_00735	COG0386	Belongs to the glutathione peroxidase family
LPB136_00750	COG0492	ferredoxin-NADP+ reductase activity
LPB136_00760	COG0484	heat shock protein binding
LPB136_00765	COG1960	acyl-CoA dehydrogenase activity
LPB136_00770	COG0183	Belongs to the thiolase family
LPB136_00775	COG1250	3-hydroxyacyl-CoA dehydrogenase
LPB136_00775	COG1024	Enoyl-CoA hydratase
LPB136_00785	COG4152	abc transporter atp-binding protein
LPB136_00790	COG1668	transmembrane transport
LPB136_00795	COG3264	Mechanosensitive ion channel
LPB136_00795	COG1196	nuclear chromosome segregation
LPB136_00815	COG0450	alkyl hydroperoxide reductase
LPB136_00820	COG3118	belongs to the thioredoxin family
LPB136_00830	COG0189	ligase activity
LPB136_00840	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LPB136_00890	COG0655	NAD(P)H dehydrogenase (quinone) activity
LPB136_00895	COG2326	polyphosphate kinase activity
LPB136_00910	COG1472	Belongs to the glycosyl hydrolase 3 family
LPB136_00930	COG0662	Cupin 2, conserved barrel domain protein
LPB136_00930	COG2207	Transcriptional regulator
LPB136_00990	COG0681	Belongs to the peptidase S26 family
LPB136_00995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LPB136_01005	COG1475	DNA binding
LPB136_01010	COG1192	Involved in chromosome partitioning
LPB136_01015	COG2195	Cleaves the N-terminal amino acid of tripeptides
LPB136_01050	COG1611	Belongs to the LOG family
LPB136_01075	COG1115	amino acid carrier protein
LPB136_01085	COG1960	acyl-CoA dehydrogenase activity
LPB136_01090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LPB136_01100	COG1187	pseudouridine synthase activity
LPB136_01105	COG0343	queuine tRNA-ribosyltransferase activity
LPB136_01115	COG0697	spore germination
LPB136_01120	COG0825	malonyl-CoA metabolic process
LPB136_01130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPB136_01135	COG2986	histidine ammonia-lyase
LPB136_01145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LPB136_01145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LPB136_01150	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LPB136_01170	COG1090	epimerase
LPB136_01225	COG0326	Molecular chaperone. Has ATPase activity
LPB136_01240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPB136_01270	COG1234	tRNA 3'-trailer cleavage
LPB136_01285	COG0540	Belongs to the ATCase OTCase family
LPB136_01295	COG0659	secondary active sulfate transmembrane transporter activity
LPB136_01320	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LPB136_01325	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPB136_01335	COG0564	pseudouridine synthase activity
LPB136_01345	COG0542	response to heat
LPB136_01360	COG0791	NLP P60 protein
LPB136_01365	COG0183	Belongs to the thiolase family
LPB136_01415	COG0653	protein targeting
LPB136_01430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPB136_01440	COG0489	protein tyrosine kinase activity
LPB136_01450	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LPB136_01455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LPB136_01460	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LPB136_01470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LPB136_01480	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LPB136_01485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPB136_01500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LPB136_01520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LPB136_01525	COG1528	Iron-storage protein
LPB136_01550	COG0497	DNA recombination
LPB136_01560	COG1216	Glycosyl transferase, family 2
LPB136_01565	COG1393	Belongs to the ArsC family
LPB136_01570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LPB136_01605	COG3275	phosphorelay sensor kinase activity
LPB136_01625	COG3279	Response regulator of the LytR AlgR family
LPB136_01640	COG0010	Belongs to the arginase family
LPB136_01645	COG1228	amidohydrolase
LPB136_01655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LPB136_01660	COG0590	tRNA wobble adenosine to inosine editing
LPB136_01675	COG0706	membrane insertase activity
LPB136_01680	COG0504	CTP synthase activity
LPB136_01685	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LPB136_01690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPB136_01700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPB136_01705	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_01750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LPB136_01785	COG3813	Protein conserved in bacteria
LPB136_01795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LPB136_01800	COG2890	protein-(glutamine-N5) methyltransferase activity
LPB136_01805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPB136_01810	COG0456	acetyltransferase
LPB136_01820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPB136_01820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPB136_01825	COG1011	Hydrolase
LPB136_01830	COG0697	spore germination
LPB136_01835	COG1739	Uncharacterized protein family UPF0029
LPB136_01855	COG0539	negative regulation of cytoplasmic translation
LPB136_01860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPB136_01915	COG1678	Uncharacterized ACR, COG1678
LPB136_01920	COG0776	regulation of translation
LPB136_01925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LPB136_01930	COG0514	ATP-dependent DNA helicase (RecQ)
LPB136_01945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPB136_01955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPB136_01960	COG0714	Associated with various cellular activities
LPB136_02000	COG2326	polyphosphate kinase activity
LPB136_02015	COG1104	cysteine desulfurase activity
LPB136_02050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LPB136_02055	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LPB136_02085	COG2270	Major facilitator Superfamily
LPB136_02090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPB136_02110	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LPB136_02120	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LPB136_02165	COG0321	lipoyl(octanoyl) transferase activity
LPB136_02165	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LPB136_02170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LPB136_02185	COG4771	TonB-dependent receptor
LPB136_02205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPB136_02230	COG0482	sulfurtransferase activity
LPB136_02270	COG1595	DNA-templated transcription, initiation
LPB136_02275	COG0300	oxidoreductase activity
LPB136_02280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LPB136_02285	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LPB136_02290	COG2996	Protein conserved in bacteria
LPB136_02305	COG0179	Fumarylacetoacetate (FAA) hydrolase
LPB136_02310	COG1546	Belongs to the CinA family
LPB136_02310	COG1058	Belongs to the CinA family
LPB136_02315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LPB136_02320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LPB136_02330	COG0552	protein localization to endoplasmic reticulum
LPB136_02335	COG0154	amidase activity
LPB136_02340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LPB136_02355	COG1136	(ABC) transporter
LPB136_02365	COG0045	succinate-CoA ligase (ADP-forming) activity
LPB136_02370	COG0583	DNA-binding transcription factor activity
LPB136_02375	COG1280	lysine exporter protein (LysE YggA)
LPB136_02390	COG0556	nucleotide-excision repair
LPB136_02410	COG1131	(ABC) transporter
LPB136_02445	COG1132	(ABC) transporter
LPB136_02450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LPB136_02455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPB136_02465	COG1862	Preprotein translocase
LPB136_02475	COG0237	dephospho-CoA kinase activity
LPB136_02490	COG0009	L-threonylcarbamoyladenylate synthase
LPB136_02525	COG2234	aminopeptidase activity
LPB136_02530	COG1120	ATPase activity
LPB136_02535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LPB136_02540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LPB136_02550	COG2183	response to ionizing radiation
LPB136_02555	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LPB136_02565	COG0339	signal peptide processing
LPB136_02580	COG1295	ribonuclease BN
LPB136_02585	COG0124	histidyl-tRNA synthetase
LPB136_02590	COG0302	gtp cyclohydrolase
LPB136_02595	COG1278	Cold shock
LPB136_02600	COG4895	conserved protein (DUF2196)
LPB136_02625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LPB136_02635	COG2329	Antibiotic biosynthesis monooxygenase
LPB136_02645	COG4166	transmembrane transport
LPB136_02665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LPB136_02675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LPB136_02685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPB136_02695	COG0583	DNA-binding transcription factor activity
LPB136_02705	COG0105	UTP biosynthetic process
LPB136_02710	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LPB136_02725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPB136_02740	COG1703	isobutyryl-CoA mutase activity
LPB136_02745	COG1595	DNA-templated transcription, initiation
LPB136_02760	COG0215	cysteine-tRNA ligase activity
LPB136_02765	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LPB136_02770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LPB136_02810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LPB136_02815	COG0602	queuosine metabolic process
LPB136_02820	COG0433	COG0433 Predicted ATPase
LPB136_02850	COG0116	Belongs to the methyltransferase superfamily
LPB136_02880	COG2356	endonuclease I
LPB136_02885	COG5297	Belongs to the glycosyl hydrolase family 6
LPB136_02885	COG4733	cellulase activity
LPB136_02890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPB136_02890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LPB136_02895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LPB136_02915	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_02920	COG3956	TIGRFAM MazG family protein
LPB136_02930	COG0242	peptide deformylase activity
LPB136_02940	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LPB136_02950	COG0463	Glycosyl transferase, family 2
LPB136_02960	COG0617	tRNA 3'-terminal CCA addition
LPB136_02970	COG1132	(ABC) transporter
LPB136_02975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPB136_02980	COG0463	Glycosyl transferase, family 2
LPB136_02995	COG4974	Belongs to the 'phage' integrase family
LPB136_03015	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LPB136_03030	COG0167	dihydroorotate dehydrogenase activity
LPB136_03055	COG1730	sister chromatid segregation
LPB136_03075	COG0516	GMP reductase activity
LPB136_03075	COG0517	IMP dehydrogenase activity
LPB136_03105	COG1794	racemase activity, acting on amino acids and derivatives
LPB136_03115	COG0668	transmembrane transport
LPB136_03125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LPB136_03130	COG1914	H( )-stimulated, divalent metal cation uptake system
LPB136_03135	COG2186	Transcriptional regulator
LPB136_03145	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_03155	COG4771	TonB-dependent receptor
LPB136_03175	COG0210	DNA helicase
LPB136_03185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LPB136_03195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LPB136_03200	COG0484	heat shock protein binding
LPB136_03235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LPB136_03260	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LPB136_03265	COG0083	homoserine kinase activity
LPB136_03270	COG0460	homoserine dehydrogenase
LPB136_03270	COG0527	aspartate kinase activity
LPB136_03280	COG0686	Belongs to the AlaDH PNT family
LPB136_03290	COG2204	response regulator
LPB136_03295	COG1078	dGTPase activity
LPB136_03300	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPB136_03305	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LPB136_03305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPB136_03310	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPB136_03315	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LPB136_03325	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LPB136_03330	COG0612	Peptidase, M16
LPB136_03335	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_03350	COG1607	acyl-coa hydrolase
LPB136_03365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LPB136_03375	COG0402	S-adenosylhomocysteine deaminase activity
LPB136_03440	COG1522	sequence-specific DNA binding
LPB136_03445	COG0022	dehydrogenase e1 component
LPB136_03450	COG2130	NADP-dependent
LPB136_03455	COG1132	(ABC) transporter
LPB136_03460	COG0564	pseudouridine synthase activity
LPB136_03465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPB136_03470	COG2814	Major facilitator Superfamily
LPB136_03485	COG3279	Response regulator of the LytR AlgR family
LPB136_03490	COG3275	phosphorelay sensor kinase activity
LPB136_03505	COG1136	(ABC) transporter
LPB136_03510	COG1136	(ABC) transporter
LPB136_03510	COG0577	efflux transmembrane transporter activity
LPB136_03525	COG1309	transcriptional regulator
LPB136_03540	COG1979	alcohol dehydrogenase
LPB136_03570	COG2249	NAD(P)H dehydrogenase (quinone) activity
LPB136_03585	COG1733	regulation of RNA biosynthetic process
LPB136_03595	COG4181	ATPase activity
LPB136_03635	COG0352	thiamine-phosphate diphosphorylase activity
LPB136_03645	COG2066	Belongs to the glutaminase family
LPB136_03655	COG1278	Cold shock
LPB136_03660	COG1388	LysM domain
LPB136_03660	COG0791	NLP P60 protein
LPB136_03710	COG0012	GTP binding
LPB136_03715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LPB136_03725	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LPB136_03735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LPB136_03745	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LPB136_03765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPB136_03770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LPB136_03795	COG4452	Inner membrane protein CreD
LPB136_03800	COG4682	membrane
LPB136_03810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LPB136_03810	COG0140	phosphoribosyl-ATP diphosphatase activity
LPB136_03815	COG0107	imidazoleglycerol-phosphate synthase activity
LPB136_03820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LPB136_03830	COG0131	Imidazoleglycerol-phosphate dehydratase
LPB136_03835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LPB136_03840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LPB136_03845	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LPB136_03850	COG0697	spore germination
LPB136_03880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LPB136_03885	COG0438	transferase activity, transferring glycosyl groups
LPB136_03890	COG3959	Transketolase, thiamine diphosphate binding domain
LPB136_03920	COG2195	Cleaves the N-terminal amino acid of tripeptides
LPB136_03925	COG0019	diaminopimelate decarboxylase activity
LPB136_03935	COG0359	binds to the 23S rRNA
LPB136_03940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LPB136_03945	COG0360	Binds together with S18 to 16S ribosomal RNA
LPB136_03955	COG0579	oxidoreductase
LPB136_03965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LPB136_03985	COG4628	conserved protein (DUF2132)
LPB136_03990	COG0006	proline dipeptidase activity
LPB136_03995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LPB136_04010	COG1322	Protein conserved in bacteria
LPB136_04015	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LPB136_04030	COG1899	peptidyl-lysine modification to peptidyl-hypusine
LPB136_04035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPB136_04035	COG3153	acetyltransferase
LPB136_04040	COG0010	Belongs to the arginase family
LPB136_04060	COG0598	Magnesium transport protein CorA
LPB136_04075	COG0542	response to heat
LPB136_04095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LPB136_04105	COG0424	maF-like protein
LPB136_04110	COG3958	Transketolase
LPB136_04125	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LPB136_04130	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LPB136_04135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LPB136_04155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPB136_04165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LPB136_04195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LPB136_04200	COG1022	Amp-dependent synthetase and ligase
LPB136_04205	COG1022	Amp-dependent synthetase and ligase
LPB136_04225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPB136_04230	COG3263	regulation of cellular component size
LPB136_04235	COG4953	penicillin-binding protein 1C
LPB136_04240	COG2373	Large extracellular alpha-helical protein
LPB136_04245	COG0513	Belongs to the DEAD box helicase family
LPB136_04275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LPB136_04285	COG4974	Belongs to the 'phage' integrase family
LPB136_04385	COG0456	acetyltransferase
LPB136_04385	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LPB136_04400	COG3279	Response regulator of the LytR AlgR family
LPB136_04405	COG3275	phosphorelay sensor kinase activity
LPB136_04425	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LPB136_04430	COG1690	Belongs to the RtcB family
LPB136_04465	COG1131	(ABC) transporter
LPB136_04470	COG1363	Peptidase, m42
LPB136_04500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPB136_04505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LPB136_04515	COG2204	response regulator
LPB136_04520	COG3852	Histidine kinase
LPB136_04530	COG1253	flavin adenine dinucleotide binding
LPB136_04535	COG0783	Belongs to the Dps family
LPB136_04545	COG0488	(ABC) transporter
LPB136_04560	COG0514	ATP-dependent DNA helicase (RecQ)
LPB136_04565	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LPB136_04565	COG0517	IMP dehydrogenase activity
LPB136_04570	COG0805	protein transport
LPB136_04580	COG1137	ATPase activity
LPB136_04585	COG1183	phosphatidylcholine synthase activity
LPB136_04605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LPB136_04665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LPB136_04675	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LPB136_04685	COG0463	Glycosyl transferase, family 2
LPB136_04690	COG2089	acid synthase
LPB136_04695	COG1083	cytidylyl-transferase
LPB136_04710	COG1216	Glycosyl transferase, family 2
LPB136_04745	COG2885	chlorophyll binding
LPB136_04775	COG1418	mRNA catabolic process
LPB136_04810	COG1047	Peptidyl-prolyl cis-trans
LPB136_04815	COG0156	8-amino-7-oxononanoate synthase activity
LPB136_04840	COG4977	sequence-specific DNA binding
LPB136_04860	COG0783	Belongs to the Dps family
LPB136_04865	COG0668	transmembrane transport
LPB136_04885	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LPB136_04905	COG0714	Associated with various cellular activities
LPB136_04935	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LPB136_04940	COG0668	transmembrane transport
LPB136_04980	COG0813	purine-nucleoside phosphorylase activity
LPB136_05000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LPB136_05020	COG0534	Mate efflux family protein
LPB136_05025	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LPB136_05035	COG1674	ftsk spoiiie
LPB136_05050	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LPB136_05050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LPB136_05055	COG3340	Belongs to the peptidase S51 family
LPB136_05105	COG2318	DinB family
LPB136_05115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPB136_05115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPB136_05135	COG0277	FAD linked oxidase domain protein
LPB136_05135	COG0247	lactate metabolic process
LPB136_05145	COG0525	valine-tRNA ligase activity
LPB136_05160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPB136_05165	COG0436	Aminotransferase
LPB136_05170	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LPB136_05175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LPB136_05200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LPB136_05230	COG3876	Protein conserved in bacteria
LPB136_05260	COG0018	arginyl-trna synthetase
LPB136_05270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPB136_05325	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
LPB136_05355	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LPB136_05360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LPB136_05365	COG1595	DNA-templated transcription, initiation
LPB136_05380	COG4771	TonB-dependent receptor
LPB136_05425	COG3275	phosphorelay sensor kinase activity
LPB136_05430	COG1408	metallophosphoesterase
LPB136_05435	COG3279	Response regulator of the LytR AlgR family
LPB136_05445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LPB136_05450	COG0626	cystathionine gamma-synthase activity
LPB136_05475	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPB136_05480	COG0673	inositol 2-dehydrogenase activity
LPB136_05485	COG1250	3-hydroxyacyl-CoA dehydrogenase
LPB136_05500	COG1136	(ABC) transporter
LPB136_05500	COG0577	efflux transmembrane transporter activity
LPB136_05505	COG1136	(ABC) transporter
LPB136_05505	COG0577	efflux transmembrane transporter activity
LPB136_05510	COG1136	(ABC) transporter
LPB136_05515	COG3011	Protein conserved in bacteria
LPB136_05535	COG2897	thiosulfate sulfurtransferase activity
LPB136_05540	COG0189	ligase activity
LPB136_05545	COG1301	dicarboxylic acid transport
LPB136_05580	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LPB136_05585	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LPB136_05590	COG1702	phosphate starvation-inducible protein PhoH
LPB136_05620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPB136_05625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LPB136_05680	COG0592	DNA-directed DNA polymerase activity
LPB136_05695	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
LPB136_05700	COG0405	Gamma-glutamyltransferase
LPB136_05715	COG0564	pseudouridine synthase activity
LPB136_05720	COG0336	Belongs to the RNA methyltransferase TrmD family
LPB136_05725	COG0335	large ribosomal subunit rRNA binding
LPB136_05735	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LPB136_05775	COG2197	response regulator
LPB136_05795	COG0488	(ABC) transporter
LPB136_05815	COG1902	pentaerythritol trinitrate reductase activity
LPB136_05815	COG0446	pyridine nucleotide-disulphide oxidoreductase
LPB136_05825	COG1846	Transcriptional regulator
LPB136_05900	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LPB136_05910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LPB136_05920	COG0217	transcriptional regulatory protein
LPB136_05945	COG4948	Mandelate Racemase Muconate Lactonizing
LPB136_05960	COG1575	Belongs to the MenA family. Type 1 subfamily
LPB136_05965	COG0247	lactate metabolic process
LPB136_05965	COG2181	nitrate reductase activity
LPB136_05970	COG0247	lactate metabolic process
LPB136_05970	COG2181	nitrate reductase activity
LPB136_05980	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPB136_05985	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LPB136_05995	COG1803	Methylglyoxal synthase
LPB136_06005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LPB136_06010	COG0205	6-phosphofructokinase activity
LPB136_06015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPB136_06025	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LPB136_06040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPB136_06115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LPB136_06120	COG0085	RNA polymerase activity
LPB136_06125	COG0222	ribosome binding
LPB136_06130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LPB136_06135	COG0081	regulation of translation
LPB136_06140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LPB136_06190	COG4974	Belongs to the 'phage' integrase family
LPB136_06195	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LPB136_06255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LPB136_06260	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPB136_06275	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPB136_06280	COG0408	coproporphyrinogen oxidase activity
LPB136_06295	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LPB136_06300	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LPB136_06310	COG0113	porphobilinogen synthase activity
LPB136_06320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LPB136_06335	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LPB136_06345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LPB136_06350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPB136_06355	COG1902	pentaerythritol trinitrate reductase activity
LPB136_06365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LPB136_06370	COG0259	pyridoxamine-phosphate oxidase activity
LPB136_06395	COG1663	tetraacyldisaccharide 4'-kinase activity
LPB136_06400	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LPB136_06415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LPB136_06440	COG1760	l-serine dehydratase
LPB136_06445	COG3022	response to hydroperoxide
LPB136_06455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LPB136_06455	COG1333	cytochrome c biogenesis protein
LPB136_06470	COG4464	protein tyrosine phosphatase activity
LPB136_06480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPB136_06485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LPB136_06500	COG0295	cytidine deaminase activity
LPB136_06510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPB136_06515	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LPB136_06515	COG0519	Catalyzes the synthesis of GMP from XMP
LPB136_06520	COG1388	LysM domain
LPB136_06520	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPB136_06525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LPB136_06535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LPB136_06555	COG0673	inositol 2-dehydrogenase activity
LPB136_06590	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LPB136_06595	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LPB136_06600	COG1482	cell wall glycoprotein biosynthetic process
LPB136_06620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LPB136_06625	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LPB136_06630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPB136_06645	COG0285	dihydrofolate synthase activity
LPB136_06655	COG0848	biopolymer transport protein
LPB136_06665	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LPB136_06680	COG1960	acyl-CoA dehydrogenase activity
LPB136_06685	COG0101	tRNA pseudouridine synthase activity
LPB136_06740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LPB136_06745	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LPB136_06750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LPB136_06770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LPB136_06790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LPB136_06825	COG0174	glutamine synthetase
LPB136_06915	COG2010	Cytochrome c
LPB136_06935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPB136_06940	COG2217	Heavy metal translocating P-type atpase
LPB136_06960	COG2264	protein methyltransferase activity
LPB136_06965	COG0149	triose-phosphate isomerase activity
LPB136_06970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPB136_06985	COG0284	orotidine-5'-phosphate decarboxylase activity
LPB136_06990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LPB136_07010	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LPB136_07020	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LPB136_07020	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LPB136_07020	COG1703	isobutyryl-CoA mutase activity
LPB136_07050	COG0159	tryptophan synthase activity
LPB136_07055	COG0133	tryptophan synthase activity
LPB136_07060	COG0135	phosphoribosylanthranilate isomerase activity
LPB136_07065	COG0134	indole-3-glycerol-phosphate synthase activity
LPB136_07075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LPB136_07080	COG0512	Glutamine amidotransferase of anthranilate synthase
LPB136_07085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPB136_07115	COG1397	ADP-ribosylglycohydrolase
LPB136_07120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LPB136_07125	COG0154	amidase activity
LPB136_07135	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LPB136_07140	COG0187	DNA topoisomerase II activity
LPB136_07160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPB136_07165	COG0563	adenylate kinase activity
LPB136_07170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LPB136_07205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LPB136_07210	COG2814	Major facilitator Superfamily
LPB136_07255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LPB136_07260	COG0848	biopolymer transport protein
LPB136_07265	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LPB136_07275	COG1132	(ABC) transporter
LPB136_07280	COG0101	tRNA pseudouridine synthase activity
LPB136_07300	COG2197	response regulator
LPB136_07315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPB136_07320	COG1253	flavin adenine dinucleotide binding
LPB136_07345	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LPB136_07360	COG0589	response to stress
LPB136_07365	COG2885	chlorophyll binding
LPB136_07365	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LPB136_07385	COG0668	transmembrane transport
LPB136_07400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LPB136_07410	COG3279	Response regulator of the LytR AlgR family
LPB136_07415	COG3275	phosphorelay sensor kinase activity
LPB136_07420	COG4206	TonB-dependent receptor
LPB136_07420	COG1629	transport
LPB136_07435	COG1705	Flagellar rod assembly protein muramidase FlgJ
LPB136_07440	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LPB136_07450	COG0488	(ABC) transporter
LPB136_07480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LPB136_07495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LPB136_07525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LPB136_07530	COG0459	protein refolding
LPB136_07575	COG0138	bifunctional purine biosynthesis protein purh
LPB136_07580	COG1077	Cell shape determining protein MreB Mrl
LPB136_07595	COG0768	penicillin binding
LPB136_07600	COG0772	Belongs to the SEDS family
LPB136_07605	COG0268	Binds directly to 16S ribosomal RNA
LPB136_07615	COG0442	prolyl-tRNA aminoacylation
LPB136_07630	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LPB136_07635	COG2226	methyltransferase
LPB136_07655	COG1595	DNA-templated transcription, initiation
LPB136_07660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPB136_07665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LPB136_07680	COG1271	oxidase subunit
LPB136_07685	COG1294	oxidase, subunit
LPB136_07715	COG1610	YqeY-like protein
LPB136_07720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LPB136_07735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPB136_07740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LPB136_07750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LPB136_07755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPB136_07760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LPB136_07765	COG0768	penicillin binding
LPB136_07775	COG0275	rRNA processing
LPB136_07780	COG2001	Belongs to the MraZ family
LPB136_07790	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LPB136_07795	COG0564	pseudouridine synthase activity
LPB136_07800	COG1012	belongs to the aldehyde dehydrogenase family
LPB136_07825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LPB136_07835	COG0612	Peptidase, M16
LPB136_07840	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LPB136_07880	COG2226	methyltransferase
LPB136_07890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LPB136_07935	COG2824	Alkylphosphonate utilization operon protein PhnA
LPB136_07960	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LPB136_07965	COG2363	Small membrane protein
LPB136_07975	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LPB136_08010	COG1490	D-aminoacyl-tRNA deacylase activity
LPB136_08035	COG1522	sequence-specific DNA binding
LPB136_08040	COG0626	cystathionine gamma-synthase activity
LPB136_08045	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LPB136_08050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LPB136_08055	COG0228	four-way junction DNA binding
LPB136_08075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPB136_08080	COG1131	(ABC) transporter
LPB136_08090	COG0321	lipoyl(octanoyl) transferase activity
LPB136_08105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPB136_08115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LPB136_08125	COG0463	Glycosyl transferase, family 2
LPB136_08135	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LPB136_08135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPB136_08145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LPB136_08160	COG2081	HI0933 family
LPB136_08180	COG1506	peptidase
LPB136_08180	COG0823	Involved in the tonB-independent uptake of proteins
LPB136_08185	COG3104	oligopeptide transport
LPB136_08190	COG4232	protein-disulfide reductase activity
LPB136_08195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPB136_08200	COG2333	competence protein COMEC
LPB136_08200	COG0658	competence protein
LPB136_08205	COG0791	NLP P60 protein
LPB136_08210	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPB136_08220	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LPB136_08245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LPB136_08260	COG1215	transferase activity, transferring glycosyl groups
LPB136_08270	COG1609	Transcriptional regulator
LPB136_08295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LPB136_08300	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LPB136_08320	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LPB136_08360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPB136_08370	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LPB136_08375	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LPB136_08380	COG0339	signal peptide processing
LPB136_08400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPB136_08415	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LPB136_08435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LPB136_08440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LPB136_08445	COG0006	proline dipeptidase activity
LPB136_08450	COG0006	proline dipeptidase activity
LPB136_08465	COG3938	Belongs to the proline racemase family
LPB136_08495	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LPB136_08500	COG1185	polyribonucleotide nucleotidyltransferase activity
LPB136_08505	COG4974	Belongs to the 'phage' integrase family
LPB136_08630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPB136_08705	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPB136_08750	COG1428	Deoxynucleoside kinase
LPB136_08765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LPB136_08770	COG0358	DNA primase activity
LPB136_08775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LPB136_08785	COG0544	peptidyl-prolyl cis-trans isomerase activity
LPB136_08790	COG1950	PFAM Membrane protein of
LPB136_08815	COG0596	Alpha beta hydrolase
LPB136_08820	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LPB136_08830	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LPB136_08840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LPB136_08860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LPB136_08870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LPB136_08875	COG0745	RESPONSE REGULATOR receiver
LPB136_08880	COG5002	protein histidine kinase activity
LPB136_08890	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPB136_08915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LPB136_08925	COG1160	GTP binding
LPB136_08945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPB136_08950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPB136_08960	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPB136_08975	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LPB136_08980	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LPB136_08995	COG2363	Small membrane protein
LPB136_09020	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_09040	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_09045	COG1960	acyl-CoA dehydrogenase activity
LPB136_09060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LPB136_09065	COG0415	Belongs to the DNA photolyase family
LPB136_09080	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_09095	COG0702	epimerase
LPB136_09105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LPB136_09115	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
LPB136_09145	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LPB136_09175	COG4585	Histidine kinase
LPB136_09195	COG0501	Belongs to the peptidase M48B family
LPB136_09205	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LPB136_09225	COG2226	methyltransferase
LPB136_09230	COG1477	protein flavinylation
LPB136_09255	COG0513	Belongs to the DEAD box helicase family
LPB136_09300	COG0668	transmembrane transport
LPB136_09310	COG1214	PFAM Peptidase M22, glycoprotease
LPB136_09325	COG2322	membrane
LPB136_09330	COG1999	signal sequence binding
LPB136_09355	COG0109	protoheme IX farnesyltransferase activity
LPB136_09370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LPB136_09390	COG0509	glycine decarboxylation via glycine cleavage system
LPB136_09400	COG0632	four-way junction helicase activity
LPB136_09425	COG2814	Major facilitator Superfamily
LPB136_09430	COG0314	molybdopterin synthase activity
LPB136_09450	COG0315	cyclic pyranopterin monophosphate synthase activity
LPB136_09450	COG0746	molybdenum cofactor guanylyltransferase activity
LPB136_09460	COG0303	'Molybdopterin
LPB136_09470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LPB136_09475	COG0322	excinuclease ABC activity
LPB136_09480	COG1752	Esterase of the alpha-beta hydrolase superfamily
LPB136_09500	COG1530	ribonuclease E activity
LPB136_09505	COG0776	regulation of translation
LPB136_09510	COG1194	a g-specific adenine glycosylase
LPB136_09515	COG0629	single-stranded DNA binding
LPB136_09545	COG0697	spore germination
LPB136_09550	COG0612	Peptidase, M16
LPB136_09555	COG0612	Peptidase, M16
LPB136_09560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LPB136_09565	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LPB136_09590	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LPB136_09600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LPB136_09605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LPB136_09615	COG0484	heat shock protein binding
LPB136_09625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LPB136_09645	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LPB136_09650	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LPB136_09660	COG1805	sodium ion transport
LPB136_09675	COG2967	ApaG domain
LPB136_09690	COG1012	belongs to the aldehyde dehydrogenase family
LPB136_09700	COG0513	Belongs to the DEAD box helicase family
LPB136_09705	COG0357	Ribosomal RNA small subunit methyltransferase G
LPB136_09710	COG3239	Fatty acid desaturase
LPB136_09730	COG0084	hydrolase, TatD family'
LPB136_09775	COG3119	arylsulfatase activity
LPB136_09780	COG1114	Component of the transport system for branched-chain amino acids
LPB136_09800	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LPB136_09820	COG0719	Fe-S assembly protein
LPB136_09830	COG0396	ATPase activity
LPB136_09835	COG0719	Fe-S assembly protein
LPB136_09840	COG0688	phosphatidylethanolamine metabolic process
LPB136_09845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPB136_09865	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPB136_09890	COG0784	Response regulator, receiver
LPB136_09890	COG2205	protein histidine kinase activity
LPB136_09910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPB136_09915	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LPB136_09920	COG0193	aminoacyl-tRNA hydrolase activity
LPB136_09925	COG0720	synthase
LPB136_09935	COG0534	Mate efflux family protein
LPB136_09980	COG0166	Belongs to the GPI family
LPB136_10000	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LPB136_10010	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LPB136_10025	COG0492	ferredoxin-NADP+ reductase activity
LPB136_10035	COG0489	protein tyrosine kinase activity
LPB136_10045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LPB136_10060	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LPB136_10065	COG1652	LysM domain
LPB136_10075	COG1561	YicC-like family, N-terminal region
LPB136_10080	COG0194	GDP metabolic process
LPB136_10085	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LPB136_10090	COG4942	peptidase
LPB136_10100	COG2258	MOSC domain
LPB136_10105	COG1970	mechanosensitive ion channel activity
LPB136_10110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LPB136_10150	COG0626	cystathionine gamma-synthase activity
LPB136_10165	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LPB136_10175	COG0527	aspartate kinase activity
LPB136_10185	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LPB136_10190	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LPB136_10195	COG2885	chlorophyll binding
LPB136_10195	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LPB136_10200	COG0156	8-amino-7-oxononanoate synthase activity
LPB136_10205	COG1074	ATP-dependent DNA helicase activity
LPB136_10220	COG4771	TonB-dependent receptor
LPB136_10240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LPB136_10255	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LPB136_10260	COG0463	Glycosyl transferase, family 2
LPB136_10275	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LPB136_10290	COG2095	MarC family integral membrane protein
LPB136_10300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPB136_10315	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LPB136_10320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LPB136_10340	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LPB136_10365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPB136_10370	COG1328	CTP reductase activity
LPB136_10370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LPB136_10375	COG1278	Cold shock
LPB136_10380	COG3279	Response regulator of the LytR AlgR family
LPB136_10385	COG0745	RESPONSE REGULATOR receiver
LPB136_10385	COG2972	Histidine kinase
LPB136_10390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LPB136_10395	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPB136_10415	COG0640	Transcriptional regulator
LPB136_10420	COG1253	flavin adenine dinucleotide binding
LPB136_10440	COG2151	metal-sulfur cluster biosynthetic enzyme
LPB136_10445	COG2166	iron-sulfur cluster assembly
LPB136_10465	COG0741	lytic transglycosylase activity
LPB136_10465	COG1388	LysM domain
LPB136_10470	COG0708	Exodeoxyribonuclease III
LPB136_10485	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LPB136_10490	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LPB136_10500	COG1774	PSP1 C-terminal conserved region
LPB136_10545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LPB136_10555	COG1505	serine-type exopeptidase activity
LPB136_10560	COG2072	flavoprotein involved in K transport
LPB136_10565	COG3590	peptidase
LPB136_10570	COG3842	ATPase activity
LPB136_10605	COG4221	oxidoreductase activity
LPB136_10645	COG1012	belongs to the aldehyde dehydrogenase family
LPB136_10650	COG1446	asparaginase
LPB136_10660	COG0300	oxidoreductase activity
LPB136_10675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LPB136_10695	COG0756	dUTP diphosphatase activity
LPB136_10705	COG2153	protein acetylation
LPB136_10710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LPB136_10715	COG1187	pseudouridine synthase activity
LPB136_10735	COG2153	protein acetylation
LPB136_10740	COG0698	ribose 5-phosphate isomerase
LPB136_10745	COG1597	lipid kinase activity
LPB136_10750	COG0557	exoribonuclease II activity
LPB136_10760	COG0393	Putative heavy-metal-binding
LPB136_10770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPB136_10800	COG0445	tRNA wobble uridine modification
LPB136_10805	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LPB136_10830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPB136_10845	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LPB136_10895	COG0628	permease
LPB136_10915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LPB136_10935	COG0488	(ABC) transporter
LPB136_10945	COG0745	RESPONSE REGULATOR receiver
LPB136_10950	COG5002	protein histidine kinase activity
LPB136_10955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LPB136_10960	COG0151	Belongs to the GarS family
LPB136_11015	COG0793	Belongs to the peptidase S41A family
LPB136_11020	COG0594	ribonuclease P activity
LPB136_11065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LPB136_11070	COG1757	Na H antiporter
LPB136_11090	COG1538	Outer membrane efflux protein
LPB136_11100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPB136_11110	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LPB136_11140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LPB136_11145	COG1053	succinate dehydrogenase
LPB136_11155	COG0300	oxidoreductase activity
LPB136_11160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPB136_11175	COG1040	competence protein
LPB136_11185	COG0423	glycine-tRNA ligase activity
LPB136_11200	COG0006	proline dipeptidase activity
LPB136_11205	COG0513	Belongs to the DEAD box helicase family
LPB136_11290	COG2217	Heavy metal translocating P-type atpase
LPB136_11325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPB136_11335	COG2217	Heavy metal translocating P-type atpase
LPB136_11400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LPB136_11405	COG0066	3-isopropylmalate dehydratase activity
LPB136_11410	COG0473	3-isopropylmalate dehydrogenase activity
LPB136_11415	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LPB136_11420	COG0004	ammonium transporteR
LPB136_11425	COG0347	Belongs to the P(II) protein family
LPB136_11435	COG0067	glutamate synthase
LPB136_11435	COG0070	glutamate synthase
LPB136_11435	COG0069	glutamate synthase activity
LPB136_11445	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LPB136_11450	COG0165	Argininosuccinate lyase
LPB136_11460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LPB136_11470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LPB136_11475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LPB136_11480	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LPB136_11485	COG0137	argininosuccinate synthase activity
LPB136_11495	COG0129	dihydroxy-acid dehydratase activity
LPB136_11500	COG0028	Belongs to the TPP enzyme family
LPB136_11510	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LPB136_11515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LPB136_11520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPB136_11540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LPB136_11575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPB136_11600	COG0356	it plays a direct role in the translocation of protons across the membrane
LPB136_11605	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LPB136_11610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LPB136_11615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LPB136_11620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LPB136_11625	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LPB136_11630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LPB136_11655	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LPB136_11655	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LPB136_11670	COG1573	uracil-dna glycosylase
LPB136_11685	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LPB136_11690	COG2020	methyltransferase activity
LPB136_11715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LPB136_11725	COG1288	antiporter activity
LPB136_11735	COG0584	glycerophosphoryl diester phosphodiesterase
LPB136_11750	COG0196	riboflavin kinase activity
LPB136_11755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LPB136_11775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LPB136_11780	COG2239	Acts as a magnesium transporter
LPB136_11790	COG4585	Histidine kinase
LPB136_11800	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LPB136_11805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPB136_11825	COG1595	DNA-templated transcription, initiation
LPB136_11835	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LPB136_11840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LPB136_11860	COG1999	signal sequence binding
LPB136_11880	COG2268	Band 7 protein
LPB136_11915	COG0495	leucyl-tRNA aminoacylation
LPB136_11925	COG1946	Acyl-CoA thioesterase
LPB136_11940	COG1381	Involved in DNA repair and RecF pathway recombination
LPB136_11955	COG1272	protein, Hemolysin III
LPB136_11965	COG0180	Tryptophanyl-tRNA synthetase
LPB136_11975	COG0667	Aldo Keto reductase
LPB136_11990	COG0126	phosphoglycerate kinase activity
LPB136_11995	COG0470	DNA polymerase III
LPB136_12005	COG1024	Enoyl-CoA hydratase
LPB136_12030	COG2169	Transcriptional regulator
LPB136_12035	COG1418	mRNA catabolic process
LPB136_12055	COG3655	Transcriptional regulator
LPB136_12090	COG0629	single-stranded DNA binding
LPB136_12115	COG1629	transport
LPB136_12115	COG4206	TonB-dependent receptor
LPB136_12145	COG0469	pyruvate kinase activity
LPB136_12155	COG0571	ribonuclease III activity
LPB136_12160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPB136_12165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LPB136_12175	COG0328	RNA-DNA hybrid ribonuclease activity
LPB136_12175	COG3341	Caulimovirus viroplasmin
LPB136_12215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LPB136_12230	COG2267	carboxylic ester hydrolase activity
LPB136_12240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPB136_12240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPB136_12245	COG1619	proteins homologs of microcin C7 resistance protein MccF
LPB136_12255	COG0792	nuclease activity
LPB136_12270	COG0300	oxidoreductase activity
LPB136_12295	COG1061	Type III restriction enzyme res subunit
LPB136_12305	COG0288	reversible hydration of carbon dioxide
LPB136_12310	COG0659	secondary active sulfate transmembrane transporter activity
LPB136_12335	COG2304	oxidoreductase activity
LPB136_12340	COG2304	oxidoreductase activity
LPB136_12355	COG0714	Associated with various cellular activities
LPB136_12375	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPB136_12380	COG0793	Belongs to the peptidase S41A family
LPB136_12395	COG1522	sequence-specific DNA binding
LPB136_12400	COG0439	Biotin carboxylase
LPB136_12405	COG0511	ligase activity, forming carbon-carbon bonds
LPB136_12410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPB136_12415	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LPB136_12425	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LPB136_12450	COG1309	transcriptional regulator
LPB136_12490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPB136_12505	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LPB136_12510	COG1968	undecaprenyl-diphosphatase activity
LPB136_12520	COG2177	Part of the ABC transporter FtsEX involved in
LPB136_12525	COG0346	lactoylglutathione lyase activity
LPB136_12550	COG4585	Histidine kinase
LPB136_12560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LPB136_12565	COG4591	ABC-type transport system involved in lipoprotein release permease component
LPB136_12570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPB136_12575	COG0481	GTPase activity
LPB136_12585	COG0252	asparaginase activity
LPB136_12590	COG0811	peptide transport
LPB136_12600	COG0848	biopolymer transport protein
LPB136_12620	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LPB136_12625	COG0017	Asparaginyl-tRNA synthetase
LPB136_12635	COG0233	cytoplasmic translational termination
LPB136_12640	COG0528	UMP kinase activity
LPB136_12645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LPB136_12650	COG0052	Belongs to the universal ribosomal protein uS2 family
LPB136_12655	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LPB136_12660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LPB136_12670	COG0564	pseudouridine synthase activity
LPB136_12685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPB136_12685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPB136_12690	COG1408	metallophosphoesterase
LPB136_12715	COG0589	response to stress
LPB136_12720	COG0779	Required for maturation of 30S ribosomal subunits
LPB136_12725	COG0195	Participates in both transcription termination and antitermination
LPB136_12730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LPB136_12740	COG3474	cytochrome
LPB136_12745	COG0437	4 iron, 4 sulfur cluster binding
LPB136_12775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LPB136_12780	COG2255	four-way junction helicase activity
LPB136_12795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPB136_12795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPB136_12835	COG2226	methyltransferase
LPB136_12865	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
LPB136_12885	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LPB136_12890	COG0563	adenylate kinase activity
LPB136_12905	COG0606	chelatase, subunit chli
LPB136_12915	COG4232	protein-disulfide reductase activity
LPB136_12920	COG0037	tRNA processing
LPB136_12940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPB136_12945	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LPB136_12950	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LPB136_12960	COG0022	dehydrogenase e1 component
LPB136_12960	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPB136_12965	COG2086	electron transfer activity
LPB136_12970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LPB136_12980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LPB136_12985	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LPB136_12995	COG0436	Aminotransferase
LPB136_13000	COG0287	Prephenate dehydrogenase
LPB136_13005	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LPB136_13010	COG1162	GTPase activity
LPB136_13015	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LPB136_13020	COG0191	fructose-bisphosphate aldolase activity
LPB136_13030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LPB136_13035	COG1428	Deoxynucleoside kinase
LPB136_13070	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LPB136_13080	COG0527	aspartate kinase activity
LPB136_13080	COG0460	homoserine dehydrogenase
LPB136_13090	COG1959	2 iron, 2 sulfur cluster binding
LPB136_13100	COG0175	sulfate reduction
LPB136_13105	COG0175	sulfate reduction
LPB136_13115	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LPB136_13125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LPB136_13125	COG1648	precorrin-2 dehydrogenase activity
LPB136_13130	COG0492	ferredoxin-NADP+ reductase activity
LPB136_13135	COG0633	Ferredoxin
LPB136_13140	COG1045	serine acetyltransferase
LPB136_13155	COG2329	Antibiotic biosynthesis monooxygenase
LPB136_13165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LPB136_13190	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LPB136_13200	COG0519	Catalyzes the synthesis of GMP from XMP
LPB136_13215	COG4221	oxidoreductase activity
LPB136_13235	COG3275	phosphorelay sensor kinase activity
LPB136_13240	COG3279	Response regulator of the LytR AlgR family
LPB136_13265	COG1187	pseudouridine synthase activity
LPB136_13285	COG1032	radical SAM domain protein
LPB136_13315	COG1595	DNA-templated transcription, initiation
LPB136_13320	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LPB136_13345	COG2884	Cell division ATP-binding protein ftsE
LPB136_13400	COG0270	DNA (cytosine-5-)-methyltransferase activity
LPB136_13420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LPB136_13515	COG0732	type I restriction modification DNA specificity domain
LPB136_13545	COG0535	radical SAM domain protein
LPB136_13560	COG3530	Putative quorum-sensing-regulated virulence factor
LPB136_13575	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LPB136_13580	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LPB136_13580	COG2885	chlorophyll binding
LPB136_13585	COG2234	aminopeptidase activity
LPB136_13590	COG1404	Belongs to the peptidase S8 family