locus-tag	class	description
BK010_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BK010_00010	COG0592	DNA-directed DNA polymerase activity
BK010_00025	COG0187	DNA topoisomerase II activity
BK010_00035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BK010_00040	COG2011	ABC-type metal ion transport system permease component
BK010_00045	COG1464	Belongs to the NlpA lipoprotein family
BK010_00055	COG1368	sulfuric ester hydrolase activity
BK010_00065	COG1968	undecaprenyl-diphosphatase activity
BK010_00080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BK010_00085	COG0745	RESPONSE REGULATOR receiver
BK010_00090	COG2770	Histidine kinase
BK010_00090	COG2205	protein histidine kinase activity
BK010_00095	COG0537	adenosine 5'-monophosphoramidase activity
BK010_00100	COG4869	propanediol catabolic process
BK010_00105	COG1078	dGTPase activity
BK010_00115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BK010_00120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BK010_00125	COG2088	sporulation resulting in formation of a cellular spore
BK010_00140	COG0534	Mate efflux family protein
BK010_00145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BK010_00150	COG0193	aminoacyl-tRNA hydrolase activity
BK010_00155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BK010_00175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BK010_00180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BK010_00180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BK010_00190	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BK010_00195	COG1307	EDD domain protein, DegV family
BK010_00205	COG0539	negative regulation of cytoplasmic translation
BK010_00210	COG0166	Belongs to the GPI family
BK010_00215	COG0802	atpase or kinase
BK010_00220	COG1214	PFAM Peptidase M22, glycoprotease
BK010_00225	COG0456	acetyltransferase
BK010_00230	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BK010_00235	COG1472	Belongs to the glycosyl hydrolase 3 family
BK010_00255	COG2226	methyltransferase
BK010_00260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BK010_00275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BK010_00280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BK010_00290	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BK010_00300	COG0546	phosphoglycolate phosphatase activity
BK010_00305	COG0492	ferredoxin-NADP+ reductase activity
BK010_00315	COG0736	holo-[acyl-carrier-protein] synthase activity
BK010_00325	COG2183	response to ionizing radiation
BK010_00330	COG0488	(ABC) transporter
BK010_00360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BK010_00390	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BK010_00440	COG2003	Belongs to the UPF0758 family
BK010_00530	COG0656	L-ascorbic acid biosynthetic process
BK010_00565	COG0667	Aldo Keto reductase
BK010_00575	COG1028	Short-chain dehydrogenase reductase Sdr
BK010_00590	COG3590	peptidase
BK010_00730	COG1607	acyl-coa hydrolase
BK010_00735	COG3246	L-lysine catabolic process to acetate
BK010_00740	COG0604	alcohol dehydrogenase
BK010_00755	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BK010_00760	COG5012	cobalamin binding
BK010_00765	COG0384	phenazine biosynthesis protein PhzF
BK010_00770	COG0534	Mate efflux family protein
BK010_00780	COG2801	Transposase and inactivated derivatives
BK010_00790	COG1228	amidohydrolase
BK010_00800	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BK010_00805	COG2986	histidine ammonia-lyase
BK010_00820	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
BK010_00830	COG3051	citrate lyase alpha subunit
BK010_00835	COG2301	Belongs to the HpcH HpaI aldolase family
BK010_00840	COG3052	prosthetic group binding
BK010_00860	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BK010_00870	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BK010_00875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BK010_00885	COG0037	tRNA processing
BK010_00890	COG0424	maF-like protein
BK010_00915	COG2211	Major facilitator Superfamily
BK010_00925	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BK010_00930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BK010_00935	COG2801	Transposase and inactivated derivatives
BK010_00945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BK010_00950	COG1882	Formate acetyltransferase
BK010_00955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BK010_00960	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BK010_00965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BK010_00975	COG0217	transcriptional regulatory protein
BK010_00980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BK010_00985	COG4656	Part of a membrane complex involved in electron transport
BK010_01005	COG4660	Part of a membrane complex involved in electron transport
BK010_01010	COG4657	Part of a membrane complex involved in electron transport
BK010_01040	COG0254	rRNA binding
BK010_01045	COG1435	thymidine kinase activity
BK010_01050	COG0590	tRNA wobble adenosine to inosine editing
BK010_01065	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BK010_01070	COG0445	tRNA wobble uridine modification
BK010_01075	COG0357	Ribosomal RNA small subunit methyltransferase G
BK010_01080	COG1192	Involved in chromosome partitioning
BK010_01085	COG1475	DNA binding
BK010_01175	COG1307	EDD domain protein, DegV family
BK010_01185	COG1940	carbohydrate kinase activity
BK010_01195	COG0051	transcription antitermination factor activity, RNA binding
BK010_01200	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BK010_01205	COG0088	Forms part of the polypeptide exit tunnel
BK010_01210	COG0089	rRNA binding
BK010_01215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BK010_01220	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BK010_01235	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BK010_01240	COG0255	Belongs to the universal ribosomal protein uL29 family
BK010_01250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BK010_01255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BK010_01260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BK010_01265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BK010_01270	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BK010_01275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BK010_01280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BK010_01285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BK010_01290	COG1841	ribosomal large subunit assembly
BK010_01295	COG0200	Binds to the 23S rRNA
BK010_01300	COG0201	protein transport
BK010_01305	COG0563	adenylate kinase activity
BK010_01310	COG0024	Methionine aminopeptidase
BK010_01315	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BK010_01320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BK010_01325	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BK010_01330	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BK010_01335	COG0202	RNA polymerase activity
BK010_01340	COG0203	ribosomal protein L17
BK010_01345	COG2356	endonuclease I
BK010_01350	COG0667	Aldo Keto reductase
BK010_01360	COG4555	ABC transporter
BK010_01380	COG2081	HI0933 family
BK010_01400	COG0492	ferredoxin-NADP+ reductase activity
BK010_01405	COG3118	belongs to the thioredoxin family
BK010_01410	COG1122	ATPase activity
BK010_01425	COG0101	tRNA pseudouridine synthase activity
BK010_01430	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BK010_01435	COG0470	DNA polymerase III
BK010_01455	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BK010_01460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK010_01460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK010_01465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BK010_01470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK010_01470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK010_01470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK010_01475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK010_01475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK010_01475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK010_01480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK010_01480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK010_01480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK010_01485	COG2252	PERMEase
BK010_01490	COG0531	amino acid
BK010_01505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BK010_01510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BK010_01520	COG2801	Transposase and inactivated derivatives
BK010_01540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BK010_01550	COG2251	uridine kinase activity
BK010_01555	COG0215	cysteine-tRNA ligase activity
BK010_01560	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BK010_01565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BK010_01585	COG0250	Participates in transcription elongation, termination and antitermination
BK010_01590	COG2514	catechol 2,3-dioxygenase activity
BK010_01595	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BK010_01605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BK010_01610	COG0081	regulation of translation
BK010_01615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BK010_01620	COG0222	ribosome binding
BK010_01625	COG2813	Specifically methylates the guanine in position
BK010_01630	COG0085	RNA polymerase activity
BK010_01635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BK010_01655	COG0156	8-amino-7-oxononanoate synthase activity
BK010_01660	COG4221	oxidoreductase activity
BK010_01675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BK010_01680	COG0049	tRNA binding
BK010_01685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BK010_01690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BK010_01700	COG0084	hydrolase, TatD family'
BK010_01705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BK010_01715	COG0360	Binds together with S18 to 16S ribosomal RNA
BK010_01720	COG0629	single-stranded DNA binding
BK010_01725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BK010_01745	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BK010_01745	COG0359	binds to the 23S rRNA
BK010_01750	COG0305	Participates in initiation and elongation during chromosome replication
BK010_01760	COG0783	Belongs to the Dps family
BK010_01765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BK010_01775	COG0009	L-threonylcarbamoyladenylate synthase
BK010_01785	COG0698	ribose 5-phosphate isomerase
BK010_01790	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BK010_01810	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BK010_01820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BK010_01825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BK010_01830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BK010_01835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BK010_01840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BK010_01850	COG2826	transposase and inactivated derivatives, IS30 family
BK010_01855	COG1739	Uncharacterized protein family UPF0029
BK010_01860	COG1307	EDD domain protein, DegV family
BK010_01870	COG3481	metal-dependent phosphohydrolase, HD sub domain
BK010_01880	COG2801	Transposase and inactivated derivatives
BK010_01910	COG2801	Transposase and inactivated derivatives
BK010_01925	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BK010_01930	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BK010_01945	COG2801	Transposase and inactivated derivatives
BK010_01955	COG1006	Multisubunit Na H antiporter MnhC subunit
BK010_01960	COG2111	Na H antiporter
BK010_01985	COG1970	mechanosensitive ion channel activity
BK010_01990	COG1307	EDD domain protein, DegV family
BK010_02000	COG1695	Transcriptional regulator
BK010_02005	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BK010_02015	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BK010_02020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BK010_02025	COG1605	Chorismate mutase
BK010_02025	COG0287	Prephenate dehydrogenase
BK010_02030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BK010_02035	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BK010_02040	COG0640	Transcriptional regulator
BK010_02045	COG2217	Heavy metal translocating P-type atpase
BK010_02050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BK010_02055	COG0416	fatty acid biosynthetic process
BK010_02060	COG0571	ribonuclease III activity
BK010_02070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BK010_02080	COG1132	(ABC) transporter
BK010_02085	COG1132	(ABC) transporter
BK010_02100	COG0587	DNA-directed DNA polymerase activity
BK010_02145	COG2801	Transposase and inactivated derivatives
BK010_02150	COG0205	6-phosphofructokinase activity
BK010_02160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BK010_02160	COG0574	Belongs to the PEP-utilizing enzyme family
BK010_02165	COG0704	Plays a role in the regulation of phosphate uptake
BK010_02170	COG0556	nucleotide-excision repair
BK010_02185	COG2195	Cleaves the N-terminal amino acid of tripeptides
BK010_02205	COG1132	(ABC) transporter
BK010_02210	COG1132	(ABC) transporter
BK010_02215	COG0673	inositol 2-dehydrogenase activity
BK010_02235	COG1070	Carbohydrate kinase
BK010_02245	COG4214	carbohydrate transport
BK010_02260	COG1321	iron dependent repressor
BK010_02260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BK010_02265	COG2239	Acts as a magnesium transporter
BK010_02270	COG2239	Acts as a magnesium transporter
BK010_02275	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BK010_02280	COG1760	l-serine dehydratase
BK010_02285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BK010_02300	COG1045	serine acetyltransferase
BK010_02305	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BK010_02310	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BK010_02315	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BK010_02320	COG1702	phosphate starvation-inducible protein PhoH
BK010_02325	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BK010_02330	COG0295	cytidine deaminase activity
BK010_02345	COG0423	glycine-tRNA ligase activity
BK010_02350	COG0358	DNA primase activity
BK010_02355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BK010_02365	COG1846	Transcriptional regulator
BK010_02390	COG4974	Belongs to the 'phage' integrase family
BK010_02485	COG0561	phosphatase activity
BK010_02515	COG1459	type II secretion system
BK010_02525	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BK010_02545	COG1674	ftsk spoiiie
BK010_02555	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BK010_02560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BK010_02570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BK010_02575	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BK010_02580	COG0552	protein localization to endoplasmic reticulum
BK010_02585	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BK010_02590	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BK010_02600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BK010_02605	COG0237	dephospho-CoA kinase activity
BK010_02615	COG1484	DNA-dependent DNA replication
BK010_02620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BK010_02625	COG4152	abc transporter atp-binding protein
BK010_02645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK010_02645	COG1263	PTS System
BK010_02645	COG2190	(PTS) system
BK010_02650	COG0489	protein tyrosine kinase activity
BK010_02665	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BK010_02670	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BK010_02675	COG0509	glycine decarboxylation via glycine cleavage system
BK010_02680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BK010_02685	COG2267	carboxylic ester hydrolase activity
BK010_02690	COG2084	Dehydrogenase
BK010_02700	COG1373	ATPase (AAA superfamily
BK010_02705	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BK010_02710	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BK010_02725	COG0557	exoribonuclease II activity
BK010_02730	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BK010_02735	COG1752	Esterase of the alpha-beta hydrolase superfamily
BK010_02740	COG0671	phosphoesterase, PA-phosphatase related
BK010_02755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BK010_02760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BK010_02765	COG3906	Belongs to the UPF0473 family
BK010_02790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BK010_02795	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BK010_02815	COG2226	methyltransferase
BK010_02830	COG1466	dna polymerase III delta subunit
BK010_02835	COG2176	DNA-directed DNA polymerase activity
BK010_02840	COG0268	Binds directly to 16S ribosomal RNA
BK010_02845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BK010_02850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BK010_02870	COG0577	efflux transmembrane transporter activity
BK010_02870	COG1136	(ABC) transporter
BK010_02875	COG1136	(ABC) transporter
BK010_02885	COG4372	Transposase
BK010_02885	COG1418	mRNA catabolic process
BK010_02890	COG1692	metallophosphoesterase
BK010_02895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BK010_02910	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BK010_02915	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BK010_02920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BK010_02930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BK010_02935	COG1278	Cold shock
BK010_02950	COG1126	abc transporter atp-binding protein
BK010_02960	COG2996	Protein conserved in bacteria
BK010_02970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BK010_02985	COG1269	ATP hydrolysis coupled proton transport
BK010_03015	COG1394	ATPase activity, coupled to movement of substances
BK010_03025	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BK010_03030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BK010_03040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BK010_03050	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BK010_03060	COG0194	GDP metabolic process
BK010_03065	COG1758	RNA polymerase activity
BK010_03070	COG0322	excinuclease ABC activity
BK010_03080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BK010_03090	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BK010_03100	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BK010_03105	COG0656	L-ascorbic acid biosynthetic process
BK010_03115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BK010_03120	COG1121	(ABC) transporter
BK010_03125	COG0803	Belongs to the bacterial solute-binding protein 9 family
BK010_03130	COG0779	Required for maturation of 30S ribosomal subunits
BK010_03135	COG0195	Participates in both transcription termination and antitermination
BK010_03135	COG2251	uridine kinase activity
BK010_03140	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BK010_03150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BK010_03155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BK010_03160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BK010_03165	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BK010_03170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BK010_03195	COG0653	protein targeting
BK010_03200	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BK010_03205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BK010_03210	COG0793	Belongs to the peptidase S41A family
BK010_03210	COG3409	Peptidoglycan-binding domain 1 protein
BK010_03215	COG2137	regulation of response to DNA damage stimulus
BK010_03230	COG0513	Belongs to the DEAD box helicase family
BK010_03260	COG3547	Transposase (IS116 IS110 IS902 family)
BK010_03270	COG0386	Belongs to the glutathione peroxidase family
BK010_03275	COG1846	Transcriptional regulator
BK010_03325	COG2801	Transposase and inactivated derivatives
BK010_03345	COG0640	Transcriptional regulator
BK010_03355	COG0640	Transcriptional regulator
BK010_03360	COG2217	Heavy metal translocating P-type atpase
BK010_03365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BK010_03370	COG2217	Heavy metal translocating P-type atpase
BK010_03390	COG2226	methyltransferase
BK010_03440	COG3328	transposase activity
BK010_03460	COG2176	DNA-directed DNA polymerase activity
BK010_03475	COG0571	ribonuclease III activity
BK010_03485	COG0640	Transcriptional regulator
BK010_03490	COG2217	Heavy metal translocating P-type atpase
BK010_03500	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BK010_03515	COG2217	Heavy metal translocating P-type atpase
BK010_03520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BK010_03550	COG0745	RESPONSE REGULATOR receiver
BK010_03605	COG1609	Transcriptional regulator
BK010_03615	COG2801	Transposase and inactivated derivatives
BK010_03620	COG0494	nUDIX hydrolase
BK010_03665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BK010_03675	COG2205	protein histidine kinase activity
BK010_03675	COG0784	Response regulator, receiver
BK010_03685	COG0009	L-threonylcarbamoyladenylate synthase
BK010_03695	COG0748	coenzyme F420 binding
BK010_03725	COG1595	DNA-templated transcription, initiation
BK010_03735	COG0405	Gamma-glutamyltransferase
BK010_03745	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BK010_03750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BK010_03765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BK010_03775	COG0439	Biotin carboxylase
BK010_03780	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BK010_03785	COG0825	malonyl-CoA metabolic process
BK010_03790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BK010_03795	COG2070	2-Nitropropane dioxygenase
BK010_03805	COG1028	Short-chain dehydrogenase reductase Sdr
BK010_03810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BK010_03820	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BK010_03820	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BK010_03840	COG0569	domain protein
BK010_03865	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BK010_03875	COG0534	Mate efflux family protein
BK010_03880	COG1733	regulation of RNA biosynthetic process
BK010_03900	COG0493	'glutamate synthase
BK010_03900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BK010_03930	COG1012	belongs to the aldehyde dehydrogenase family
BK010_03935	COG2199	diguanylate cyclase activity
BK010_03945	COG0494	nUDIX hydrolase
BK010_03950	COG1063	alcohol dehydrogenase
BK010_03955	COG0156	8-amino-7-oxononanoate synthase activity
BK010_03960	COG5001	Diguanylate cyclase
BK010_03970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BK010_04010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BK010_04025	COG2205	protein histidine kinase activity
BK010_04025	COG2198	Histidine kinase
BK010_04025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BK010_04025	COG0784	Response regulator, receiver
BK010_04030	COG3300	MHYT domain
BK010_04030	COG5001	Diguanylate cyclase
BK010_04160	COG1309	transcriptional regulator
BK010_04170	COG3839	Belongs to the ABC transporter superfamily
BK010_04175	COG1176	ABC-type spermidine putrescine transport system, permease component I
BK010_04180	COG1177	transmembrane transport
BK010_04195	COG1570	exodeoxyribonuclease VII activity
BK010_04200	COG1722	exodeoxyribonuclease VII activity
BK010_04205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BK010_04210	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BK010_04215	COG0497	DNA recombination
BK010_04220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BK010_04225	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BK010_04230	COG0513	Belongs to the DEAD box helicase family
BK010_04235	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BK010_04240	COG2801	Transposase and inactivated derivatives
BK010_04255	COG0297	glycogen (starch) synthase activity
BK010_04265	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BK010_04285	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BK010_04305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BK010_04310	COG3022	response to hydroperoxide
BK010_04315	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BK010_04320	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BK010_04325	COG1272	protein, Hemolysin III
BK010_04330	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BK010_04335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BK010_04355	COG0110	maltose O-acetyltransferase activity
BK010_04395	COG1929	Belongs to the glycerate kinase type-1 family
BK010_04400	COG0745	RESPONSE REGULATOR receiver
BK010_04440	COG3944	biosynthesis protein
BK010_04445	COG0489	protein tyrosine kinase activity
BK010_04510	COG1476	TRANSCRIPTIONal
BK010_04535	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BK010_04570	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BK010_04595	COG2188	Transcriptional regulator
BK010_04610	COG0395	ABC-type sugar transport system, permease component
BK010_04620	COG1175	transmembrane transport
BK010_04645	COG1482	cell wall glycoprotein biosynthetic process
BK010_04655	COG0366	Alpha amylase catalytic
BK010_04660	COG0438	transferase activity, transferring glycosyl groups
BK010_04670	COG1175	transmembrane transport
BK010_04675	COG3833	ABC-type maltose transport systems, permease component
BK010_04680	COG3842	ATPase activity
BK010_04685	COG3835	regulator
BK010_04755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BK010_04760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BK010_04780	COG1250	3-hydroxyacyl-CoA dehydrogenase
BK010_04830	COG0673	inositol 2-dehydrogenase activity
BK010_04865	COG0516	GMP reductase activity
BK010_04865	COG0517	IMP dehydrogenase activity
BK010_04870	COG0519	Catalyzes the synthesis of GMP from XMP
BK010_04870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BK010_04880	COG0483	inositol monophosphate 1-phosphatase activity
BK010_04890	COG0446	pyridine nucleotide-disulphide oxidoreductase
BK010_04910	COG4176	ABC-type proline glycine betaine transport system permease component
BK010_04915	COG4175	Glycine betaine
BK010_04915	COG0517	IMP dehydrogenase activity
BK010_04920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BK010_04925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BK010_04930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BK010_04945	COG0174	glutamine synthetase
BK010_04960	COG0489	protein tyrosine kinase activity
BK010_04975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BK010_05000	COG0544	peptidyl-prolyl cis-trans isomerase activity
BK010_05005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BK010_05010	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BK010_05015	COG1307	EDD domain protein, DegV family
BK010_05020	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BK010_05030	COG0525	valine-tRNA ligase activity
BK010_05035	COG0285	dihydrofolate synthase activity
BK010_05040	COG2003	Belongs to the UPF0758 family
BK010_05055	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BK010_05065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BK010_05070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BK010_05080	COG0632	four-way junction helicase activity
BK010_05085	COG2255	four-way junction helicase activity
BK010_05110	COG1363	Peptidase, m42
BK010_05115	COG0656	L-ascorbic acid biosynthetic process
BK010_05130	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BK010_05135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BK010_05140	COG0006	proline dipeptidase activity
BK010_05155	COG4152	abc transporter atp-binding protein
BK010_05170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BK010_05175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BK010_05185	COG1363	Peptidase, m42
BK010_05190	COG0742	ribosomal rna small subunit methyltransferase
BK010_05210	COG1943	Transposase
BK010_05220	COG0187	DNA topoisomerase II activity
BK010_05225	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BK010_05230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BK010_05240	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BK010_05255	COG2030	dehydratase
BK010_05260	COG1960	acyl-CoA dehydrogenase activity
BK010_05265	COG2086	electron transfer activity
BK010_05280	COG1028	Short-chain dehydrogenase reductase Sdr
BK010_05300	COG0411	ABC transporter
BK010_05305	COG0410	ABC transporter
BK010_05315	COG0427	acetyl-CoA hydrolase
BK010_05325	COG0508	dehydrogenase complex catalyzes the overall conversion of
BK010_05325	COG0596	Alpha beta hydrolase
BK010_05330	COG0252	asparaginase activity
BK010_05340	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BK010_05345	COG4974	Belongs to the 'phage' integrase family
BK010_05350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BK010_05355	COG0481	GTPase activity
BK010_05365	COG4536	flavin adenine dinucleotide binding
BK010_05370	COG1253	flavin adenine dinucleotide binding
BK010_05390	COG0596	Alpha beta hydrolase
BK010_05395	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BK010_05400	COG1253	flavin adenine dinucleotide binding
BK010_05410	COG1185	polyribonucleotide nucleotidyltransferase activity
BK010_05415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BK010_05420	COG3870	Protein conserved in bacteria
BK010_05425	COG0196	riboflavin kinase activity
BK010_05430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BK010_05435	COG3118	belongs to the thioredoxin family
BK010_05440	COG1193	negative regulation of DNA recombination
BK010_05445	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BK010_05450	COG0564	pseudouridine synthase activity
BK010_05455	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BK010_05480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BK010_05485	COG0124	histidyl-tRNA synthetase
BK010_05490	COG0519	Catalyzes the synthesis of GMP from XMP
BK010_05495	COG1490	D-aminoacyl-tRNA deacylase activity
BK010_05500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BK010_05505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BK010_05510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BK010_05520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BK010_05525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BK010_05530	COG3457	Alanine racemase
BK010_05540	COG5012	cobalamin binding
BK010_05550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BK010_05560	COG3804	dihydrodipicolinate reductase
BK010_05570	COG2096	Adenosyltransferase
BK010_05575	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BK010_05580	COG3331	DNA recombination
BK010_05660	COG0395	ABC-type sugar transport system, permease component
BK010_05675	COG1175	transmembrane transport
BK010_05680	COG0395	ABC-type sugar transport system, permease component
BK010_05690	COG0745	RESPONSE REGULATOR receiver
BK010_05715	COG1051	belongs to the nudix hydrolase family
BK010_05715	COG1056	cytidyltransferase-related domain
BK010_05725	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BK010_05740	COG0488	(ABC) transporter
BK010_05750	COG2217	Heavy metal translocating P-type atpase
BK010_05760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BK010_05765	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BK010_05770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BK010_05785	COG0443	Heat shock 70 kDa protein
BK010_05795	COG1461	Dihydroxyacetone kinase
BK010_05805	COG0095	Lipoate-protein ligase
BK010_05825	COG0275	rRNA processing
BK010_05830	COG1803	Methylglyoxal synthase
BK010_05840	COG2801	Transposase and inactivated derivatives
BK010_05850	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BK010_05855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BK010_05855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BK010_05860	COG0482	sulfurtransferase activity
BK010_05865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BK010_05875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BK010_05880	COG0297	glycogen (starch) synthase activity
BK010_05910	COG2801	Transposase and inactivated derivatives
BK010_05920	COG2135	peptidase activity
BK010_05945	COG2801	Transposase and inactivated derivatives
BK010_05960	COG0400	carboxylic ester hydrolase activity
BK010_05975	COG2801	Transposase and inactivated derivatives
BK010_05985	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BK010_06055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BK010_06075	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BK010_06085	COG1132	(ABC) transporter
BK010_06100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BK010_06105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BK010_06120	COG1695	Transcriptional regulator
BK010_06145	COG0516	GMP reductase activity
BK010_06160	COG0564	pseudouridine synthase activity
BK010_06175	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BK010_06180	COG0039	L-malate dehydrogenase activity
BK010_06185	COG0366	Alpha amylase catalytic
BK010_06190	COG0346	lactoylglutathione lyase activity
BK010_06195	COG1695	Transcriptional regulator
BK010_06220	COG0400	carboxylic ester hydrolase activity
BK010_06225	COG1846	Transcriptional regulator
BK010_06230	COG0346	lactoylglutathione lyase activity
BK010_06250	COG1187	pseudouridine synthase activity
BK010_06275	COG0546	phosphoglycolate phosphatase activity
BK010_06280	COG1136	(ABC) transporter
BK010_06280	COG0577	efflux transmembrane transporter activity
BK010_06285	COG0577	efflux transmembrane transporter activity
BK010_06285	COG1136	(ABC) transporter
BK010_06290	COG0778	Nitroreductase
BK010_06300	COG1194	a g-specific adenine glycosylase
BK010_06315	COG0343	queuine tRNA-ribosyltransferase activity
BK010_06320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BK010_06325	COG0012	GTP binding
BK010_06330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BK010_06335	COG1799	cell septum assembly
BK010_06340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BK010_06360	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BK010_06365	COG0813	purine-nucleoside phosphorylase activity
BK010_06380	COG0629	single-stranded DNA binding
BK010_06400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BK010_06405	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BK010_06410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BK010_06465	COG5001	Diguanylate cyclase
BK010_06475	COG1104	cysteine desulfurase activity
BK010_06500	COG1902	pentaerythritol trinitrate reductase activity
BK010_06535	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BK010_06540	COG1266	CAAX protease self-immunity
BK010_06550	COG0776	regulation of translation
BK010_06555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BK010_06560	COG1160	GTP binding
BK010_06565	COG0539	negative regulation of cytoplasmic translation
BK010_06570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BK010_06575	COG1187	pseudouridine synthase activity
BK010_06580	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BK010_06585	COG1132	(ABC) transporter
BK010_06590	COG1132	(ABC) transporter
BK010_06600	COG2356	endonuclease I
BK010_06625	COG0668	transmembrane transport
BK010_06675	COG2801	Transposase and inactivated derivatives
BK010_06685	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BK010_06685	COG0456	acetyltransferase
BK010_06735	COG3177	Filamentation induced by cAMP protein fic
BK010_06790	COG1461	Dihydroxyacetone kinase
BK010_06795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BK010_06805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BK010_06810	COG1162	GTPase activity
BK010_06815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BK010_06820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK010_06820	COG0072	phenylalanine-tRNA ligase activity
BK010_06825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BK010_06835	COG2176	DNA-directed DNA polymerase activity
BK010_06850	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BK010_06870	COG0495	leucyl-tRNA aminoacylation
BK010_06875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BK010_06890	COG0765	amino acid transport
BK010_06905	COG0366	Alpha amylase catalytic
BK010_06915	COG1609	Transcriptional regulator
BK010_06925	COG1523	belongs to the glycosyl hydrolase 13 family
BK010_06930	COG0366	Alpha amylase catalytic
BK010_06935	COG0058	SHG alpha-glucan phosphorylase activity
BK010_06940	COG3833	ABC-type maltose transport systems, permease component
BK010_06945	COG1175	transmembrane transport
BK010_06950	COG2182	Extracellular solute-binding protein
BK010_06960	COG1523	belongs to the glycosyl hydrolase 13 family
BK010_06980	COG0598	Magnesium transport protein CorA
BK010_07045	COG0366	Alpha amylase catalytic
BK010_07060	COG2059	Chromate
BK010_07105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BK010_07120	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BK010_07130	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BK010_07140	COG4221	oxidoreductase activity
BK010_07145	COG2235	arginine
BK010_07150	COG2801	Transposase and inactivated derivatives
BK010_07165	COG1811	Na channel or pump
BK010_07170	COG0667	Aldo Keto reductase
BK010_07200	COG0133	tryptophan synthase activity
BK010_07210	COG0798	PFAM Bile acid sodium symporter
BK010_07215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BK010_07235	COG3706	GGDEF domain
BK010_07265	COG3177	Filamentation induced by cAMP protein fic
BK010_07310	COG2801	Transposase and inactivated derivatives
BK010_07340	COG2226	methyltransferase
BK010_07365	COG4912	Dna alkylation repair
BK010_07425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BK010_07440	COG2226	methyltransferase
BK010_07630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BK010_07645	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BK010_07675	COG1061	Type III restriction enzyme res subunit
BK010_07740	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BK010_07780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BK010_07785	COG0572	uridine kinase
BK010_07795	COG2217	Heavy metal translocating P-type atpase
BK010_07835	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BK010_07840	COG4589	Belongs to the CDS family
BK010_07845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BK010_07850	COG0233	cytoplasmic translational termination
BK010_07855	COG0528	UMP kinase activity
BK010_07860	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BK010_07865	COG0052	Belongs to the universal ribosomal protein uS2 family
BK010_07870	COG0756	dUTP diphosphatase activity
BK010_07880	COG4974	Belongs to the 'phage' integrase family
BK010_07885	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BK010_07895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BK010_07935	COG4116	CYTH
BK010_07950	COG1164	Oligoendopeptidase f
BK010_07955	COG0180	Tryptophanyl-tRNA synthetase
BK010_07965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BK010_07970	COG1943	Transposase
BK010_07975	COG1609	Transcriptional regulator
BK010_07980	COG0335	large ribosomal subunit rRNA binding
BK010_07985	COG0336	Belongs to the RNA methyltransferase TrmD family
BK010_07990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BK010_07995	COG1837	Belongs to the UPF0109 family
BK010_08000	COG0228	four-way junction DNA binding
BK010_08015	COG1187	pseudouridine synthase activity
BK010_08020	COG0242	peptide deformylase activity
BK010_08030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BK010_08040	COG1956	GAF domain-containing protein
BK010_08045	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BK010_08065	COG0126	phosphoglycerate kinase activity
BK010_08075	COG3842	ATPase activity
BK010_08100	COG0822	iron-sulfur transferase activity
BK010_08105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BK010_08110	COG0719	Fe-S assembly protein
BK010_08115	COG0396	ATPase activity
BK010_08135	COG4608	Belongs to the ABC transporter superfamily
BK010_08145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BK010_08150	COG0601	transmembrane transport
BK010_08165	COG0674	pyruvate-flavodoxin oxidoreductase activity
BK010_08165	COG1013	pyruvate-flavodoxin oxidoreductase activity
BK010_08165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BK010_08165	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BK010_08170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BK010_08205	COG3615	Tellurite resistance protein tehB
BK010_08205	COG0500	methyltransferase
BK010_08220	COG5002	protein histidine kinase activity
BK010_08230	COG0704	Plays a role in the regulation of phosphate uptake
BK010_08240	COG0581	inorganic phosphate transmembrane transporter activity
BK010_08245	COG0573	inorganic phosphate transmembrane transporter activity
BK010_08250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BK010_08265	COG5001	Diguanylate cyclase
BK010_08275	COG1131	(ABC) transporter
BK010_08290	COG2364	Membrane
BK010_08320	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BK010_08325	COG1307	EDD domain protein, DegV family
BK010_08330	COG2814	Major facilitator Superfamily
BK010_08340	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BK010_08345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BK010_08355	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BK010_08365	COG1304	FMN binding
BK010_08370	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BK010_08385	COG1335	isochorismatase
BK010_08395	COG2508	Transcriptional regulator
BK010_08450	COG0708	Exodeoxyribonuclease III
BK010_08470	COG1695	Transcriptional regulator
BK010_08480	COG1943	Transposase
BK010_08485	COG1609	Transcriptional regulator
BK010_08490	COG0335	large ribosomal subunit rRNA binding
BK010_08495	COG0336	Belongs to the RNA methyltransferase TrmD family
BK010_08500	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BK010_08505	COG1837	Belongs to the UPF0109 family
BK010_08510	COG0228	four-way junction DNA binding
BK010_08525	COG1187	pseudouridine synthase activity
BK010_08530	COG0242	peptide deformylase activity
BK010_08540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BK010_08550	COG1956	GAF domain-containing protein
BK010_08555	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BK010_08575	COG0126	phosphoglycerate kinase activity
BK010_08585	COG3842	ATPase activity
BK010_08610	COG0822	iron-sulfur transferase activity
BK010_08615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BK010_08620	COG0719	Fe-S assembly protein
BK010_08625	COG0396	ATPase activity
BK010_08645	COG4608	Belongs to the ABC transporter superfamily
BK010_08655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BK010_08660	COG0601	transmembrane transport
BK010_08675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BK010_08675	COG1013	pyruvate-flavodoxin oxidoreductase activity
BK010_08675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BK010_08675	COG0674	pyruvate-flavodoxin oxidoreductase activity
BK010_08680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BK010_08715	COG3615	Tellurite resistance protein tehB
BK010_08715	COG0500	methyltransferase
BK010_08730	COG5002	protein histidine kinase activity
BK010_08740	COG0704	Plays a role in the regulation of phosphate uptake
BK010_08750	COG0581	inorganic phosphate transmembrane transporter activity
BK010_08755	COG0573	inorganic phosphate transmembrane transporter activity
BK010_08760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BK010_08775	COG5001	Diguanylate cyclase
BK010_08785	COG1131	(ABC) transporter
BK010_08800	COG2364	Membrane
BK010_08830	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BK010_08835	COG1307	EDD domain protein, DegV family
BK010_08840	COG2814	Major facilitator Superfamily
BK010_08850	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BK010_08855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BK010_08865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BK010_08875	COG1304	FMN binding
BK010_08880	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BK010_08895	COG1335	isochorismatase
BK010_08905	COG2508	Transcriptional regulator
BK010_08960	COG0708	Exodeoxyribonuclease III
BK010_08980	COG1695	Transcriptional regulator
BK010_08990	COG1943	Transposase
BK010_09005	COG0513	Belongs to the DEAD box helicase family
BK010_09050	COG0428	transporter
BK010_09065	COG1131	(ABC) transporter
BK010_09080	COG5002	protein histidine kinase activity
BK010_09085	COG0745	RESPONSE REGULATOR receiver
BK010_09145	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BK010_09145	COG0493	'glutamate synthase
BK010_09150	COG0649	NAD binding
BK010_09155	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BK010_09160	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BK010_09165	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BK010_09175	COG0651	ATP synthesis coupled electron transport
BK010_09180	COG1006	Multisubunit Na H antiporter MnhC subunit
BK010_09185	COG2111	Na H antiporter
BK010_09195	COG1320	monovalent cation:proton antiporter activity
BK010_09200	COG2212	antiporter activity
BK010_09205	COG1863	multisubunit Na H antiporter MnhE subunit
BK010_09220	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BK010_09235	COG0514	ATP-dependent DNA helicase (RecQ)
BK010_09245	COG0542	response to heat
BK010_09260	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BK010_09310	COG0326	Molecular chaperone. Has ATPase activity
BK010_09355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BK010_09365	COG1748	Saccharopine dehydrogenase
BK010_09375	COG0527	aspartate kinase activity
BK010_09380	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BK010_09385	COG2801	Transposase and inactivated derivatives
BK010_09430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BK010_09435	COG1609	Transcriptional regulator
BK010_09460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BK010_09470	COG0071	Belongs to the small heat shock protein (HSP20) family
BK010_09480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BK010_09480	COG2199	diguanylate cyclase activity
BK010_09490	COG1131	(ABC) transporter
BK010_09510	COG4325	translation initiation factor activity
BK010_09545	COG0446	pyridine nucleotide-disulphide oxidoreductase
BK010_09555	COG0596	Alpha beta hydrolase
BK010_09565	COG2197	response regulator
BK010_09585	COG0045	succinate-CoA ligase (ADP-forming) activity
BK010_09590	COG1012	belongs to the aldehyde dehydrogenase family
BK010_09600	COG0698	ribose 5-phosphate isomerase
BK010_09605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BK010_09610	COG3959	Transketolase, thiamine diphosphate binding domain
BK010_09625	COG0395	ABC-type sugar transport system, permease component
BK010_09635	COG1501	Belongs to the glycosyl hydrolase 31 family
BK010_09650	COG0330	HflC and HflK could
BK010_09655	COG1840	ABC-type Fe3 transport system, periplasmic component
BK010_09665	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BK010_09675	COG0561	phosphatase activity
BK010_09685	COG2304	oxidoreductase activity
BK010_09690	COG0745	RESPONSE REGULATOR receiver
BK010_09695	COG5002	protein histidine kinase activity
BK010_09750	COG1619	proteins homologs of microcin C7 resistance protein MccF
BK010_09790	COG1597	lipid kinase activity
BK010_09805	COG2031	fatty acid transporter
BK010_09815	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BK010_09820	COG1309	transcriptional regulator
BK010_09845	COG0010	Belongs to the arginase family
BK010_09850	COG1982	Orn Lys Arg decarboxylase major
BK010_09855	COG0668	transmembrane transport
BK010_09880	COG3706	GGDEF domain
BK010_09895	COG2801	Transposase and inactivated derivatives
BK010_09910	COG0280	phosphate acetyltransferase
BK010_09915	COG3426	butyrate kinase activity
BK010_09920	COG0501	Belongs to the peptidase M48B family
BK010_09925	COG3033	Beta-eliminating lyase
BK010_09940	COG0456	acetyltransferase
BK010_09950	COG1126	abc transporter atp-binding protein
BK010_09955	COG0765	amino acid transport
BK010_09970	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BK010_09975	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BK010_09985	COG4658	electron transport chain
BK010_09995	COG1012	belongs to the aldehyde dehydrogenase family
BK010_10005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BK010_10015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BK010_10020	COG0457	Tetratricopeptide repeat
BK010_10020	COG0705	Rhomboid family
BK010_10025	COG1136	(ABC) transporter
BK010_10025	COG0577	efflux transmembrane transporter activity
BK010_10030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BK010_10060	COG0251	oxidation-reduction process
BK010_10070	COG1105	Belongs to the carbohydrate kinase PfkB family
BK010_10080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BK010_10085	COG4496	protein, YerC YecD
BK010_10095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BK010_10095	COG1199	ATP-dependent helicase activity
BK010_10110	COG1024	Enoyl-CoA hydratase
BK010_10115	COG3706	GGDEF domain
BK010_10120	COG2203	Gaf domain
BK010_10120	COG2199	diguanylate cyclase activity
BK010_10155	COG2081	HI0933 family
BK010_10185	COG0504	CTP synthase activity
BK010_10205	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BK010_10210	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BK010_10215	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BK010_10220	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BK010_10225	COG1285	pathogenesis
BK010_10230	COG0037	tRNA processing
BK010_10235	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BK010_10240	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BK010_10255	COG4085	toxin activity
BK010_10255	COG0737	Belongs to the 5'-nucleotidase family
BK010_10255	COG1525	nuclease
BK010_10270	COG1175	transmembrane transport
BK010_10275	COG3842	ATPase activity
BK010_10295	COG0017	Asparaginyl-tRNA synthetase
BK010_10320	COG0594	ribonuclease P activity
BK010_10345	COG5001	Diguanylate cyclase
BK010_10355	COG0823	Involved in the tonB-independent uptake of proteins
BK010_10355	COG1506	peptidase
BK010_10355	COG4946	Tricorn protease homolog
BK010_10365	COG2826	transposase and inactivated derivatives, IS30 family
BK010_10375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BK010_10385	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BK010_10420	COG3935	DnaD domain protein
BK010_10655	COG1185	polyribonucleotide nucleotidyltransferase activity
BK010_10665	COG1012	belongs to the aldehyde dehydrogenase family
BK010_10665	COG1454	alcohol dehydrogenase
BK010_10675	COG3328	transposase activity
BK010_10700	COG0640	Transcriptional regulator
BK010_10710	COG0640	Transcriptional regulator
BK010_10715	COG2217	Heavy metal translocating P-type atpase
BK010_10720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BK010_10725	COG2217	Heavy metal translocating P-type atpase
BK010_10750	COG2801	Transposase and inactivated derivatives
BK010_10790	COG2801	Transposase and inactivated derivatives