locus-tag	class	description
BK011_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BK011_00010	COG0592	DNA-directed DNA polymerase activity
BK011_00025	COG0187	DNA topoisomerase II activity
BK011_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BK011_00035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BK011_00045	COG1464	Belongs to the NlpA lipoprotein family
BK011_00050	COG1368	sulfuric ester hydrolase activity
BK011_00060	COG1968	undecaprenyl-diphosphatase activity
BK011_00075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BK011_00080	COG0745	RESPONSE REGULATOR receiver
BK011_00085	COG2205	protein histidine kinase activity
BK011_00085	COG2770	Histidine kinase
BK011_00090	COG0537	adenosine 5'-monophosphoramidase activity
BK011_00095	COG4869	propanediol catabolic process
BK011_00105	COG1078	dGTPase activity
BK011_00110	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BK011_00115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BK011_00120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BK011_00125	COG2088	sporulation resulting in formation of a cellular spore
BK011_00135	COG0534	Mate efflux family protein
BK011_00140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BK011_00145	COG0193	aminoacyl-tRNA hydrolase activity
BK011_00150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BK011_00165	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BK011_00175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BK011_00180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BK011_00180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BK011_00190	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BK011_00195	COG1307	EDD domain protein, DegV family
BK011_00205	COG0539	negative regulation of cytoplasmic translation
BK011_00210	COG0166	Belongs to the GPI family
BK011_00215	COG0802	atpase or kinase
BK011_00220	COG1214	PFAM Peptidase M22, glycoprotease
BK011_00225	COG0456	acetyltransferase
BK011_00230	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BK011_00235	COG1472	Belongs to the glycosyl hydrolase 3 family
BK011_00270	COG0210	DNA helicase
BK011_00280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BK011_00285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BK011_00295	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BK011_00310	COG0492	ferredoxin-NADP+ reductase activity
BK011_00320	COG0736	holo-[acyl-carrier-protein] synthase activity
BK011_00330	COG2183	response to ionizing radiation
BK011_00335	COG0488	(ABC) transporter
BK011_00380	COG2361	Protein of unknown function DUF86
BK011_00420	COG0656	L-ascorbic acid biosynthetic process
BK011_00430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BK011_00445	COG0667	Aldo Keto reductase
BK011_00455	COG3711	transcriptional antiterminator
BK011_00455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK011_00470	COG3959	Transketolase, thiamine diphosphate binding domain
BK011_00475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BK011_00485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BK011_00495	COG1028	Short-chain dehydrogenase reductase Sdr
BK011_00510	COG3590	peptidase
BK011_00515	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BK011_00535	COG3547	Transposase (IS116 IS110 IS902 family)
BK011_00555	COG0693	protein deglycase activity
BK011_00605	COG2814	Major facilitator Superfamily
BK011_00615	COG0577	efflux transmembrane transporter activity
BK011_00615	COG1136	(ABC) transporter
BK011_00620	COG1309	transcriptional regulator
BK011_00630	COG1607	acyl-coa hydrolase
BK011_00635	COG3246	L-lysine catabolic process to acetate
BK011_00640	COG0604	alcohol dehydrogenase
BK011_00655	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BK011_00660	COG5012	cobalamin binding
BK011_00670	COG0534	Mate efflux family protein
BK011_00680	COG1228	amidohydrolase
BK011_00690	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BK011_00695	COG2986	histidine ammonia-lyase
BK011_00710	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
BK011_00720	COG3051	citrate lyase alpha subunit
BK011_00725	COG2301	Belongs to the HpcH HpaI aldolase family
BK011_00730	COG3052	prosthetic group binding
BK011_00750	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BK011_00760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BK011_00765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BK011_00775	COG0037	tRNA processing
BK011_00780	COG0424	maF-like protein
BK011_00790	COG3345	alpha-galactosidase
BK011_00805	COG2211	Major facilitator Superfamily
BK011_00810	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BK011_00815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BK011_00820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BK011_00825	COG1882	Formate acetyltransferase
BK011_00830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BK011_00835	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BK011_00840	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BK011_00855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BK011_00860	COG4656	Part of a membrane complex involved in electron transport
BK011_00865	COG1805	sodium ion transport
BK011_00880	COG4660	Part of a membrane complex involved in electron transport
BK011_00885	COG4657	Part of a membrane complex involved in electron transport
BK011_00915	COG0254	rRNA binding
BK011_00920	COG1435	thymidine kinase activity
BK011_00925	COG0590	tRNA wobble adenosine to inosine editing
BK011_00945	COG0445	tRNA wobble uridine modification
BK011_00950	COG0357	Ribosomal RNA small subunit methyltransferase G
BK011_00955	COG1192	Involved in chromosome partitioning
BK011_00960	COG1475	DNA binding
BK011_01060	COG1307	EDD domain protein, DegV family
BK011_01070	COG1940	carbohydrate kinase activity
BK011_01080	COG0051	transcription antitermination factor activity, RNA binding
BK011_01085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BK011_01090	COG0088	Forms part of the polypeptide exit tunnel
BK011_01095	COG0089	rRNA binding
BK011_01100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BK011_01105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BK011_01120	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BK011_01125	COG0255	Belongs to the universal ribosomal protein uL29 family
BK011_01135	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BK011_01140	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BK011_01145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BK011_01150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BK011_01155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BK011_01160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BK011_01165	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BK011_01170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BK011_01175	COG1841	ribosomal large subunit assembly
BK011_01180	COG0200	Binds to the 23S rRNA
BK011_01185	COG0201	protein transport
BK011_01190	COG0563	adenylate kinase activity
BK011_01195	COG0024	Methionine aminopeptidase
BK011_01200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BK011_01205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BK011_01210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BK011_01215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BK011_01220	COG0202	RNA polymerase activity
BK011_01225	COG0203	ribosomal protein L17
BK011_01230	COG2356	endonuclease I
BK011_01235	COG0667	Aldo Keto reductase
BK011_01245	COG1131	(ABC) transporter
BK011_01265	COG2081	HI0933 family
BK011_01270	COG0492	ferredoxin-NADP+ reductase activity
BK011_01275	COG3118	belongs to the thioredoxin family
BK011_01280	COG1122	ATPase activity
BK011_01290	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BK011_01295	COG0101	tRNA pseudouridine synthase activity
BK011_01300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BK011_01305	COG0470	DNA polymerase III
BK011_01310	COG1774	PSP1 C-terminal conserved region
BK011_01315	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BK011_01325	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BK011_01335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BK011_01340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK011_01340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK011_01340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK011_01345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK011_01345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK011_01345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK011_01350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK011_01350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK011_01350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK011_01365	COG2252	PERMEase
BK011_01370	COG0531	amino acid
BK011_01385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BK011_01405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BK011_01415	COG2251	uridine kinase activity
BK011_01420	COG0215	cysteine-tRNA ligase activity
BK011_01425	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BK011_01430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BK011_01450	COG0250	Participates in transcription elongation, termination and antitermination
BK011_01465	COG2514	catechol 2,3-dioxygenase activity
BK011_01470	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BK011_01480	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BK011_01485	COG0081	regulation of translation
BK011_01490	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BK011_01495	COG0222	ribosome binding
BK011_01500	COG2813	Specifically methylates the guanine in position
BK011_01505	COG0085	RNA polymerase activity
BK011_01510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BK011_01515	COG3547	Transposase (IS116 IS110 IS902 family)
BK011_01520	COG0156	8-amino-7-oxononanoate synthase activity
BK011_01525	COG0300	oxidoreductase activity
BK011_01550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BK011_01555	COG0049	tRNA binding
BK011_01560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BK011_01565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BK011_01585	COG0084	hydrolase, TatD family'
BK011_01590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BK011_01595	COG1058	Belongs to the CinA family
BK011_01595	COG1546	Belongs to the CinA family
BK011_01600	COG0360	Binds together with S18 to 16S ribosomal RNA
BK011_01605	COG0629	single-stranded DNA binding
BK011_01610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BK011_01630	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BK011_01630	COG0359	binds to the 23S rRNA
BK011_01635	COG0305	Participates in initiation and elongation during chromosome replication
BK011_01640	COG1051	belongs to the nudix hydrolase family
BK011_01640	COG1056	cytidyltransferase-related domain
BK011_01710	COG2217	Heavy metal translocating P-type atpase
BK011_01715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BK011_01745	COG0745	RESPONSE REGULATOR receiver
BK011_01770	COG3547	Transposase (IS116 IS110 IS902 family)
BK011_01805	COG0783	Belongs to the Dps family
BK011_01810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BK011_01820	COG0009	L-threonylcarbamoyladenylate synthase
BK011_01830	COG0698	ribose 5-phosphate isomerase
BK011_01835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BK011_01855	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BK011_01870	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BK011_01875	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BK011_01880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BK011_01885	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BK011_01895	COG2826	transposase and inactivated derivatives, IS30 family
BK011_01900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BK011_01905	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BK011_01915	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BK011_01930	COG2003	Belongs to the UPF0758 family
BK011_01935	COG0285	dihydrofolate synthase activity
BK011_01940	COG0525	valine-tRNA ligase activity
BK011_01945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BK011_01950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BK011_01955	COG1307	EDD domain protein, DegV family
BK011_01960	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BK011_01965	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BK011_01970	COG0544	peptidyl-prolyl cis-trans isomerase activity
BK011_02010	COG3655	Transcriptional regulator
BK011_02020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BK011_02035	COG0489	protein tyrosine kinase activity
BK011_02050	COG0174	glutamine synthetase
BK011_02065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BK011_02070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BK011_02075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BK011_02080	COG0517	IMP dehydrogenase activity
BK011_02080	COG4175	Glycine betaine
BK011_02125	COG0483	inositol monophosphate 1-phosphatase activity
BK011_02135	COG2207	Transcriptional regulator
BK011_02155	COG0375	protein maturation
BK011_02165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK011_02170	COG1120	ATPase activity
BK011_02185	COG2197	response regulator
BK011_02190	COG4585	Histidine kinase
BK011_02205	COG1131	(ABC) transporter
BK011_02210	COG3547	Transposase (IS116 IS110 IS902 family)
BK011_02215	COG1028	Short-chain dehydrogenase reductase Sdr
BK011_02220	COG2264	protein methyltransferase activity
BK011_02245	COG0395	ABC-type sugar transport system, permease component
BK011_02250	COG1175	transmembrane transport
BK011_02260	COG0366	Alpha amylase catalytic
BK011_02265	COG1609	Transcriptional regulator
BK011_02285	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BK011_02295	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BK011_02300	COG0583	DNA-binding transcription factor activity
BK011_02315	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BK011_02320	COG0519	Catalyzes the synthesis of GMP from XMP
BK011_02320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BK011_02325	COG0516	GMP reductase activity
BK011_02325	COG0517	IMP dehydrogenase activity
BK011_02335	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BK011_02340	COG0673	inositol 2-dehydrogenase activity
BK011_02375	COG0438	transferase activity, transferring glycosyl groups
BK011_02395	COG0110	maltose O-acetyltransferase activity
BK011_02410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BK011_02415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BK011_02425	COG2801	Transposase and inactivated derivatives
BK011_02490	COG3835	regulator
BK011_02495	COG3842	ATPase activity
BK011_02500	COG3833	ABC-type maltose transport systems, permease component
BK011_02505	COG1175	transmembrane transport
BK011_02515	COG0438	transferase activity, transferring glycosyl groups
BK011_02520	COG0366	Alpha amylase catalytic
BK011_02530	COG1482	cell wall glycoprotein biosynthetic process
BK011_02555	COG1175	transmembrane transport
BK011_02565	COG0395	ABC-type sugar transport system, permease component
BK011_02580	COG2188	Transcriptional regulator
BK011_02605	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BK011_02635	COG3153	acetyltransferase
BK011_02645	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BK011_02655	COG3547	Transposase (IS116 IS110 IS902 family)
BK011_02660	COG1476	TRANSCRIPTIONal
BK011_02705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BK011_02740	COG1131	(ABC) transporter
BK011_02785	COG2188	Transcriptional regulator
BK011_02800	COG0489	protein tyrosine kinase activity
BK011_02805	COG3944	biosynthesis protein
BK011_02845	COG0745	RESPONSE REGULATOR receiver
BK011_02850	COG1929	Belongs to the glycerate kinase type-1 family
BK011_02855	COG1744	ABC transporter substrate-binding protein PnrA-like
BK011_02885	COG0110	maltose O-acetyltransferase activity
BK011_02900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BK011_02905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BK011_02910	COG1272	protein, Hemolysin III
BK011_02915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BK011_02920	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BK011_02925	COG3022	response to hydroperoxide
BK011_02930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BK011_02940	COG2963	transposase activity
BK011_02945	COG2801	Transposase and inactivated derivatives
BK011_02960	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BK011_02975	COG0018	arginyl-trna synthetase
BK011_02985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BK011_02990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BK011_02995	COG0297	glycogen (starch) synthase activity
BK011_03000	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BK011_03010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BK011_03020	COG0497	DNA recombination
BK011_03025	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BK011_03030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BK011_03035	COG1722	exodeoxyribonuclease VII activity
BK011_03040	COG1570	exodeoxyribonuclease VII activity
BK011_03055	COG1309	transcriptional regulator
BK011_03190	COG5001	Diguanylate cyclase
BK011_03190	COG3300	MHYT domain
BK011_03195	COG5002	protein histidine kinase activity
BK011_03195	COG0784	Response regulator, receiver
BK011_03210	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BK011_03240	COG3547	Transposase (IS116 IS110 IS902 family)
BK011_03250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BK011_03260	COG5001	Diguanylate cyclase
BK011_03265	COG0156	8-amino-7-oxononanoate synthase activity
BK011_03270	COG1063	alcohol dehydrogenase
BK011_03275	COG0494	nUDIX hydrolase
BK011_03285	COG1012	belongs to the aldehyde dehydrogenase family
BK011_03300	COG1013	pyruvate-flavodoxin oxidoreductase activity
BK011_03300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BK011_03300	COG0674	pyruvate-flavodoxin oxidoreductase activity
BK011_03315	COG0493	'glutamate synthase
BK011_03345	COG1733	regulation of RNA biosynthetic process
BK011_03350	COG0534	Mate efflux family protein
BK011_03365	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BK011_03390	COG0569	domain protein
BK011_03420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BK011_03425	COG1028	Short-chain dehydrogenase reductase Sdr
BK011_03435	COG2070	2-Nitropropane dioxygenase
BK011_03440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BK011_03450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BK011_03455	COG0439	Biotin carboxylase
BK011_03465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BK011_03480	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BK011_03485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BK011_03490	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BK011_03500	COG0405	Gamma-glutamyltransferase
BK011_03530	COG0194	GDP metabolic process
BK011_03540	COG0009	L-threonylcarbamoyladenylate synthase
BK011_03550	COG0784	Response regulator, receiver
BK011_03550	COG2205	protein histidine kinase activity
BK011_03560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BK011_03595	COG0494	nUDIX hydrolase
BK011_03615	COG0519	Catalyzes the synthesis of GMP from XMP
BK011_03625	COG0488	(ABC) transporter
BK011_03645	COG2217	Heavy metal translocating P-type atpase
BK011_03650	COG0640	Transcriptional regulator
BK011_03655	COG0571	ribonuclease III activity
BK011_03685	COG2801	Transposase and inactivated derivatives
BK011_03715	COG1846	Transcriptional regulator
BK011_03720	COG0386	Belongs to the glutathione peroxidase family
BK011_03750	COG0513	Belongs to the DEAD box helicase family
BK011_03760	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BK011_03765	COG2137	regulation of response to DNA damage stimulus
BK011_03770	COG0793	Belongs to the peptidase S41A family
BK011_03770	COG3409	Peptidoglycan-binding domain 1 protein
BK011_03775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BK011_03780	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BK011_03785	COG0653	protein targeting
BK011_03815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BK011_03820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BK011_03825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BK011_03830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BK011_03835	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BK011_03845	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BK011_03850	COG2251	uridine kinase activity
BK011_03850	COG0195	Participates in both transcription termination and antitermination
BK011_03855	COG0779	Required for maturation of 30S ribosomal subunits
BK011_03865	COG1121	(ABC) transporter
BK011_03870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BK011_03880	COG0656	L-ascorbic acid biosynthetic process
BK011_03895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BK011_03905	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BK011_03915	COG0322	excinuclease ABC activity
BK011_03920	COG1758	RNA polymerase activity
BK011_03925	COG0194	GDP metabolic process
BK011_03950	COG4555	ABC transporter
BK011_03965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BK011_03975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BK011_03980	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BK011_03985	COG1395	domain, Protein
BK011_03990	COG1394	ATPase activity, coupled to movement of substances
BK011_04020	COG1269	ATP hydrolysis coupled proton transport
BK011_04035	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BK011_04045	COG2996	Protein conserved in bacteria
BK011_04060	COG0765	amino acid transport
BK011_04065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BK011_04070	COG1278	Cold shock
BK011_04075	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BK011_04080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BK011_04085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BK011_04090	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BK011_04095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BK011_04110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BK011_04115	COG1692	metallophosphoesterase
BK011_04120	COG1418	mRNA catabolic process
BK011_04120	COG4372	Transposase
BK011_04130	COG1136	(ABC) transporter
BK011_04135	COG1136	(ABC) transporter
BK011_04135	COG0577	efflux transmembrane transporter activity
BK011_04155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BK011_04165	COG0268	Binds directly to 16S ribosomal RNA
BK011_04170	COG2176	DNA-directed DNA polymerase activity
BK011_04175	COG1466	dna polymerase III delta subunit
BK011_04190	COG2226	methyltransferase
BK011_04210	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BK011_04215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BK011_04240	COG3906	Belongs to the UPF0473 family
BK011_04245	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BK011_04250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BK011_04260	COG0671	phosphoesterase, PA-phosphatase related
BK011_04265	COG1752	Esterase of the alpha-beta hydrolase superfamily
BK011_04270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BK011_04275	COG0557	exoribonuclease II activity
BK011_04290	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BK011_04300	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BK011_04305	COG1373	ATPase (AAA superfamily
BK011_04315	COG2084	Dehydrogenase
BK011_04320	COG2267	carboxylic ester hydrolase activity
BK011_04330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BK011_04335	COG0509	glycine decarboxylation via glycine cleavage system
BK011_04340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BK011_04345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BK011_04350	COG0489	protein tyrosine kinase activity
BK011_04370	COG0596	Alpha beta hydrolase
BK011_04385	COG4152	abc transporter atp-binding protein
BK011_04390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BK011_04400	COG1484	DNA-dependent DNA replication
BK011_04410	COG0237	dephospho-CoA kinase activity
BK011_04415	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BK011_04425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BK011_04430	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BK011_04435	COG0552	protein localization to endoplasmic reticulum
BK011_04440	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BK011_04445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BK011_04455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BK011_04460	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BK011_04470	COG1674	ftsk spoiiie
BK011_04490	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BK011_04500	COG1459	type II secretion system
BK011_04530	COG0561	phosphatase activity
BK011_04565	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BK011_04600	COG1846	Transcriptional regulator
BK011_04610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BK011_04615	COG0358	DNA primase activity
BK011_04620	COG0423	glycine-tRNA ligase activity
BK011_04635	COG0295	cytidine deaminase activity
BK011_04640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BK011_04645	COG1702	phosphate starvation-inducible protein PhoH
BK011_04650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BK011_04660	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BK011_04665	COG1045	serine acetyltransferase
BK011_04680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BK011_04685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BK011_04690	COG1760	l-serine dehydratase
BK011_04695	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BK011_04705	COG2239	Acts as a magnesium transporter
BK011_04710	COG2239	Acts as a magnesium transporter
BK011_04715	COG1321	iron dependent repressor
BK011_04725	COG0673	inositol 2-dehydrogenase activity
BK011_04735	COG1132	(ABC) transporter
BK011_04740	COG1132	(ABC) transporter
BK011_04760	COG2195	Cleaves the N-terminal amino acid of tripeptides
BK011_04775	COG0556	nucleotide-excision repair
BK011_04780	COG0704	Plays a role in the regulation of phosphate uptake
BK011_04800	COG0574	Belongs to the PEP-utilizing enzyme family
BK011_04800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BK011_04810	COG0205	6-phosphofructokinase activity
BK011_04825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BK011_04855	COG0587	DNA-directed DNA polymerase activity
BK011_04870	COG1132	(ABC) transporter
BK011_04875	COG1132	(ABC) transporter
BK011_04885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BK011_04895	COG0571	ribonuclease III activity
BK011_04900	COG0416	fatty acid biosynthetic process
BK011_04905	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BK011_04910	COG2217	Heavy metal translocating P-type atpase
BK011_04915	COG0640	Transcriptional regulator
BK011_04920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BK011_04925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BK011_04930	COG1605	Chorismate mutase
BK011_04930	COG0287	Prephenate dehydrogenase
BK011_04935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BK011_04940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BK011_04950	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BK011_04955	COG1695	Transcriptional regulator
BK011_04965	COG1307	EDD domain protein, DegV family
BK011_04970	COG1970	mechanosensitive ion channel activity
BK011_04995	COG2111	Na H antiporter
BK011_05000	COG1006	Multisubunit Na H antiporter MnhC subunit
BK011_05010	COG0546	phosphoglycolate phosphatase activity
BK011_05015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BK011_05020	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BK011_05030	COG3481	metal-dependent phosphohydrolase, HD sub domain
BK011_05040	COG1307	EDD domain protein, DegV family
BK011_05045	COG1739	Uncharacterized protein family UPF0029
BK011_05050	COG2826	transposase and inactivated derivatives, IS30 family
BK011_05060	COG0632	four-way junction helicase activity
BK011_05065	COG2255	four-way junction helicase activity
BK011_05090	COG1363	Peptidase, m42
BK011_05095	COG0656	L-ascorbic acid biosynthetic process
BK011_05110	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BK011_05115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BK011_05120	COG0006	proline dipeptidase activity
BK011_05150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BK011_05155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BK011_05165	COG1363	Peptidase, m42
BK011_05170	COG0742	ribosomal rna small subunit methyltransferase
BK011_05180	COG3763	UPF0154 protein
BK011_05190	COG0187	DNA topoisomerase II activity
BK011_05195	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BK011_05200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BK011_05210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BK011_05225	COG2030	dehydratase
BK011_05230	COG1960	acyl-CoA dehydrogenase activity
BK011_05235	COG2086	electron transfer activity
BK011_05250	COG1028	Short-chain dehydrogenase reductase Sdr
BK011_05270	COG0411	ABC transporter
BK011_05275	COG0410	ABC transporter
BK011_05285	COG0427	acetyl-CoA hydrolase
BK011_05295	COG0596	Alpha beta hydrolase
BK011_05300	COG0252	asparaginase activity
BK011_05310	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BK011_05315	COG4974	Belongs to the 'phage' integrase family
BK011_05320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BK011_05325	COG0481	GTPase activity
BK011_05335	COG4536	flavin adenine dinucleotide binding
BK011_05340	COG1253	flavin adenine dinucleotide binding
BK011_05365	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BK011_05370	COG1253	flavin adenine dinucleotide binding
BK011_05380	COG1185	polyribonucleotide nucleotidyltransferase activity
BK011_05395	COG1454	alcohol dehydrogenase
BK011_05395	COG1012	belongs to the aldehyde dehydrogenase family
BK011_05405	COG5002	protein histidine kinase activity
BK011_05405	COG5001	Diguanylate cyclase
BK011_05430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BK011_05435	COG3870	Protein conserved in bacteria
BK011_05440	COG0196	riboflavin kinase activity
BK011_05445	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BK011_05465	COG3118	belongs to the thioredoxin family
BK011_05470	COG1193	negative regulation of DNA recombination
BK011_05475	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BK011_05480	COG0564	pseudouridine synthase activity
BK011_05485	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BK011_05505	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BK011_05510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BK011_05515	COG0124	histidyl-tRNA synthetase
BK011_05520	COG0519	Catalyzes the synthesis of GMP from XMP
BK011_05535	COG1490	D-aminoacyl-tRNA deacylase activity
BK011_05540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BK011_05545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BK011_05550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BK011_05560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BK011_05565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BK011_05570	COG3457	Alanine racemase
BK011_05580	COG5012	cobalamin binding
BK011_05600	COG3804	dihydrodipicolinate reductase
BK011_05605	COG2096	Adenosyltransferase
BK011_05610	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BK011_05615	COG3331	DNA recombination
BK011_05655	COG0588	phosphoglycerate mutase activity
BK011_05665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BK011_05670	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BK011_05675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BK011_05700	COG0629	single-stranded DNA binding
BK011_05720	COG0813	purine-nucleoside phosphorylase activity
BK011_05725	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BK011_05740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BK011_05745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BK011_05750	COG1799	cell septum assembly
BK011_05755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BK011_05760	COG0012	GTP binding
BK011_05765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BK011_05770	COG0343	queuine tRNA-ribosyltransferase activity
BK011_05785	COG1194	a g-specific adenine glycosylase
BK011_05795	COG0778	Nitroreductase
BK011_05800	COG1136	(ABC) transporter
BK011_05800	COG0577	efflux transmembrane transporter activity
BK011_05805	COG0577	efflux transmembrane transporter activity
BK011_05805	COG1136	(ABC) transporter
BK011_05810	COG0546	phosphoglycolate phosphatase activity
BK011_05875	COG0346	lactoylglutathione lyase activity
BK011_05880	COG1846	Transcriptional regulator
BK011_05885	COG0400	carboxylic ester hydrolase activity
BK011_05905	COG1695	Transcriptional regulator
BK011_05915	COG0039	L-malate dehydrogenase activity
BK011_05920	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BK011_05925	COG0564	pseudouridine synthase activity
BK011_05950	COG0516	GMP reductase activity
BK011_05970	COG0697	spore germination
BK011_05995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BK011_06000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BK011_06015	COG1132	(ABC) transporter
BK011_06025	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BK011_06045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BK011_06095	COG2210	Belongs to the sulfur carrier protein TusA family
BK011_06100	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BK011_06115	COG0400	carboxylic ester hydrolase activity
BK011_06145	COG2135	peptidase activity
BK011_06170	COG0297	glycogen (starch) synthase activity
BK011_06185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BK011_06190	COG0482	sulfurtransferase activity
BK011_06200	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BK011_06210	COG1803	Methylglyoxal synthase
BK011_06215	COG0275	rRNA processing
BK011_06235	COG0095	Lipoate-protein ligase
BK011_06245	COG1461	Dihydroxyacetone kinase
BK011_06255	COG0443	Heat shock 70 kDa protein
BK011_06270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BK011_06275	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BK011_06280	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BK011_06295	COG2217	Heavy metal translocating P-type atpase
BK011_06305	COG0488	(ABC) transporter
BK011_06360	COG0395	ABC-type sugar transport system, permease component
BK011_06365	COG1175	transmembrane transport
BK011_06380	COG0395	ABC-type sugar transport system, permease component
BK011_06410	COG1609	Transcriptional regulator
BK011_06450	COG5001	Diguanylate cyclase
BK011_06460	COG0459	protein refolding
BK011_06465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BK011_06480	COG1104	cysteine desulfurase activity
BK011_06510	COG1902	pentaerythritol trinitrate reductase activity
BK011_06545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BK011_06550	COG1266	CAAX protease self-immunity
BK011_06560	COG0776	regulation of translation
BK011_06565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BK011_06570	COG1160	GTP binding
BK011_06575	COG0539	negative regulation of cytoplasmic translation
BK011_06580	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BK011_06585	COG1187	pseudouridine synthase activity
BK011_06590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BK011_06595	COG1132	(ABC) transporter
BK011_06610	COG2356	endonuclease I
BK011_06900	COG4894	glucomannan catabolic process
BK011_06925	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BK011_06925	COG0456	acetyltransferase
BK011_06955	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BK011_06955	COG0456	acetyltransferase
BK011_06990	COG1162	GTPase activity
BK011_07020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BK011_07095	COG1307	EDD domain protein, DegV family
BK011_07110	COG1131	(ABC) transporter
BK011_07115	COG1131	(ABC) transporter
BK011_07195	COG0390	transport system, permease component
BK011_07200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BK011_07255	COG2801	Transposase and inactivated derivatives
BK011_07270	COG1461	Dihydroxyacetone kinase
BK011_07275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BK011_07285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BK011_07290	COG1162	GTPase activity
BK011_07295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BK011_07305	COG0072	phenylalanine-tRNA ligase activity
BK011_07305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK011_07310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BK011_07320	COG2176	DNA-directed DNA polymerase activity
BK011_07330	COG1242	4 iron, 4 sulfur cluster binding
BK011_07335	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BK011_07355	COG0495	leucyl-tRNA aminoacylation
BK011_07360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BK011_07370	COG0765	amino acid transport
BK011_07385	COG0366	Alpha amylase catalytic
BK011_07395	COG1609	Transcriptional regulator
BK011_07405	COG1523	belongs to the glycosyl hydrolase 13 family
BK011_07410	COG0366	Alpha amylase catalytic
BK011_07415	COG0058	SHG alpha-glucan phosphorylase activity
BK011_07420	COG3833	ABC-type maltose transport systems, permease component
BK011_07425	COG1175	transmembrane transport
BK011_07430	COG2182	Extracellular solute-binding protein
BK011_07440	COG1523	belongs to the glycosyl hydrolase 13 family
BK011_07450	COG0598	Magnesium transport protein CorA
BK011_07515	COG0366	Alpha amylase catalytic
BK011_07530	COG2059	Chromate
BK011_07540	COG0584	glycerophosphoryl diester phosphodiesterase
BK011_07550	COG2211	Major facilitator Superfamily
BK011_07555	COG1501	Belongs to the glycosyl hydrolase 31 family
BK011_07580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BK011_07595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BK011_07605	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BK011_07620	COG2826	transposase and inactivated derivatives, IS30 family
BK011_07625	COG4221	oxidoreductase activity
BK011_07630	COG2235	arginine
BK011_07640	COG1811	Na channel or pump
BK011_07645	COG0667	Aldo Keto reductase
BK011_07675	COG0133	tryptophan synthase activity
BK011_07685	COG0798	PFAM Bile acid sodium symporter
BK011_07695	COG3547	Transposase (IS116 IS110 IS902 family)
BK011_07705	COG0701	Predicted permease
BK011_07715	COG3706	GGDEF domain
BK011_07790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BK011_07830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BK011_07865	COG1131	(ABC) transporter
BK011_07880	COG0667	Aldo Keto reductase
BK011_07890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BK011_07910	COG0542	response to heat
BK011_07920	COG1506	peptidase
BK011_07920	COG0823	Involved in the tonB-independent uptake of proteins
BK011_07920	COG4946	Tricorn protease homolog
BK011_07965	COG0826	peptidase U32
BK011_08000	COG3620	sequence-specific DNA binding
BK011_08085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BK011_08090	COG0572	uridine kinase
BK011_08100	COG2217	Heavy metal translocating P-type atpase
BK011_08145	COG4589	Belongs to the CDS family
BK011_08150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BK011_08155	COG0233	cytoplasmic translational termination
BK011_08160	COG0528	UMP kinase activity
BK011_08165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BK011_08170	COG0052	Belongs to the universal ribosomal protein uS2 family
BK011_08175	COG0756	dUTP diphosphatase activity
BK011_08185	COG4974	Belongs to the 'phage' integrase family
BK011_08190	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BK011_08200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BK011_08255	COG4116	CYTH
BK011_08270	COG1164	Oligoendopeptidase f
BK011_08275	COG0180	Tryptophanyl-tRNA synthetase
BK011_08285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BK011_08295	COG1609	Transcriptional regulator
BK011_08300	COG0335	large ribosomal subunit rRNA binding
BK011_08305	COG0336	Belongs to the RNA methyltransferase TrmD family
BK011_08310	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BK011_08315	COG1837	Belongs to the UPF0109 family
BK011_08320	COG0228	four-way junction DNA binding
BK011_08335	COG1187	pseudouridine synthase activity
BK011_08340	COG0242	peptide deformylase activity
BK011_08350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BK011_08360	COG1956	GAF domain-containing protein
BK011_08365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BK011_08385	COG0126	phosphoglycerate kinase activity
BK011_08395	COG3842	ATPase activity
BK011_08420	COG0822	iron-sulfur transferase activity
BK011_08425	COG3547	Transposase (IS116 IS110 IS902 family)
BK011_08430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BK011_08435	COG0719	Fe-S assembly protein
BK011_08440	COG0396	ATPase activity
BK011_08465	COG4608	Belongs to the ABC transporter superfamily
BK011_08465	COG4608	Belongs to the ABC transporter superfamily
BK011_08470	COG0444	Belongs to the ABC transporter superfamily
BK011_08475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BK011_08480	COG0601	transmembrane transport
BK011_08495	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BK011_08495	COG0674	pyruvate-flavodoxin oxidoreductase activity
BK011_08495	COG1013	pyruvate-flavodoxin oxidoreductase activity
BK011_08495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BK011_08500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BK011_08540	COG5002	protein histidine kinase activity
BK011_08550	COG0704	Plays a role in the regulation of phosphate uptake
BK011_08560	COG0581	inorganic phosphate transmembrane transporter activity
BK011_08565	COG0573	inorganic phosphate transmembrane transporter activity
BK011_08595	COG5001	Diguanylate cyclase
BK011_08605	COG1131	(ABC) transporter
BK011_08625	COG2364	Membrane
BK011_08645	COG1136	(ABC) transporter
BK011_08655	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BK011_08660	COG1307	EDD domain protein, DegV family
BK011_08665	COG2814	Major facilitator Superfamily
BK011_08675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BK011_08680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BK011_08705	COG0454	-acetyltransferase
BK011_08715	COG5290	Psort location Cytoplasmic, score
BK011_08745	COG0708	Exodeoxyribonuclease III
BK011_08775	COG0513	Belongs to the DEAD box helicase family
BK011_08815	COG0428	transporter
BK011_08820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BK011_08845	COG1131	(ABC) transporter
BK011_08865	COG5002	protein histidine kinase activity
BK011_08865	COG3850	Histidine kinase
BK011_08870	COG0745	RESPONSE REGULATOR receiver
BK011_08895	COG3620	sequence-specific DNA binding
BK011_08915	COG0456	acetyltransferase
BK011_08940	COG2207	Transcriptional regulator
BK011_08960	COG0571	ribonuclease III activity
BK011_08965	COG0514	ATP-dependent DNA helicase (RecQ)
BK011_08985	COG0494	nUDIX hydrolase
BK011_08990	COG1061	Type III restriction enzyme res subunit
BK011_09025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BK011_09035	COG1748	Saccharopine dehydrogenase
BK011_09045	COG0527	aspartate kinase activity
BK011_09050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BK011_09090	COG4555	ABC transporter
BK011_09095	COG0456	acetyltransferase
BK011_09105	COG3547	Transposase (IS116 IS110 IS902 family)
BK011_09120	COG4325	translation initiation factor activity
BK011_09130	COG1131	(ABC) transporter
BK011_09140	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BK011_09140	COG2199	diguanylate cyclase activity
BK011_09150	COG0071	Belongs to the small heat shock protein (HSP20) family
BK011_09160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BK011_09185	COG1609	Transcriptional regulator
BK011_09190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BK011_09195	COG3547	Transposase (IS116 IS110 IS902 family)
BK011_09215	COG0446	pyridine nucleotide-disulphide oxidoreductase
BK011_09220	COG1943	Transposase
BK011_09235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BK011_09240	COG0045	succinate-CoA ligase (ADP-forming) activity
BK011_09245	COG1012	belongs to the aldehyde dehydrogenase family
BK011_09255	COG0698	ribose 5-phosphate isomerase
BK011_09260	COG3958	Transketolase
BK011_09265	COG3959	Transketolase, thiamine diphosphate binding domain
BK011_09280	COG0395	ABC-type sugar transport system, permease component
BK011_09290	COG1501	Belongs to the glycosyl hydrolase 31 family
BK011_09305	COG1309	transcriptional regulator
BK011_09320	COG0330	HflC and HflK could
BK011_09355	COG3459	Glycosyltransferase 36 associated
BK011_09385	COG0395	ABC-type sugar transport system, permease component
BK011_09410	COG3119	arylsulfatase activity
BK011_09425	COG0366	Alpha amylase catalytic
BK011_09435	COG0673	inositol 2-dehydrogenase activity
BK011_09460	COG0641	radical SAM
BK011_09465	COG0561	phosphatase activity
BK011_09475	COG2304	oxidoreductase activity
BK011_09480	COG2801	Transposase and inactivated derivatives
BK011_09530	COG1840	ABC-type Fe3 transport system, periplasmic component
BK011_09535	COG1178	ABC-type Fe3 transport system permease component
BK011_09550	COG0561	phosphatase activity
BK011_09555	COG4399	Belongs to the UPF0754 family
BK011_09575	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BK011_09580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BK011_09580	COG0140	phosphoribosyl-ATP diphosphatase activity
BK011_09590	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BK011_09595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BK011_09605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BK011_09610	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BK011_09620	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BK011_09635	COG1175	transmembrane transport
BK011_09640	COG3833	ABC-type maltose transport systems, permease component
BK011_09650	COG1609	Transcriptional regulator
BK011_09680	COG0601	transmembrane transport
BK011_09685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BK011_09690	COG0444	Belongs to the ABC transporter superfamily
BK011_09695	COG4608	Belongs to the ABC transporter superfamily
BK011_09700	COG4166	transmembrane transport
BK011_09720	COG1619	proteins homologs of microcin C7 resistance protein MccF
BK011_09760	COG5658	integral membrane protein
BK011_09770	COG1597	lipid kinase activity
BK011_09800	COG2031	fatty acid transporter
BK011_09810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BK011_09815	COG1309	transcriptional regulator
BK011_09830	COG2801	Transposase and inactivated derivatives
BK011_09860	COG1373	ATPase (AAA superfamily
BK011_09865	COG3547	Transposase (IS116 IS110 IS902 family)
BK011_09875	COG1982	Orn Lys Arg decarboxylase major
BK011_09880	COG0668	transmembrane transport
BK011_09885	COG2207	Transcriptional regulator
BK011_09885	COG3708	Transcriptional regulator
BK011_09905	COG3706	GGDEF domain
BK011_09925	COG3639	organic phosphonate transmembrane transporter activity
BK011_09935	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BK011_09945	COG0737	Belongs to the 5'-nucleotidase family
BK011_09950	COG0280	phosphate acetyltransferase
BK011_09955	COG3426	butyrate kinase activity
BK011_09960	COG0501	Belongs to the peptidase M48B family
BK011_09965	COG3033	Beta-eliminating lyase
BK011_09985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BK011_10005	COG0765	amino acid transport
BK011_10020	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BK011_10025	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BK011_10035	COG4658	electron transport chain
BK011_10045	COG1012	belongs to the aldehyde dehydrogenase family
BK011_10050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BK011_10075	COG1136	(ABC) transporter
BK011_10090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BK011_10095	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BK011_10115	COG0251	oxidation-reduction process
BK011_10140	COG4496	protein, YerC YecD
BK011_10145	COG1764	response to oxidative stress
BK011_10170	COG1024	Enoyl-CoA hydratase
BK011_10175	COG3706	GGDEF domain
BK011_10180	COG4191	Histidine kinase
BK011_10200	COG2971	BadF BadG BcrA BcrD
BK011_10205	COG1472	Belongs to the glycosyl hydrolase 3 family
BK011_10210	COG3876	Protein conserved in bacteria
BK011_10220	COG0395	ABC-type sugar transport system, permease component
BK011_10245	COG0395	ABC-type sugar transport system, permease component
BK011_10270	COG5632	N-Acetylmuramoyl-L-alanine amidase
BK011_10270	COG3409	Peptidoglycan-binding domain 1 protein
BK011_10275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BK011_10285	COG1649	PFAM Uncharacterised BCR, COG1649
BK011_10290	COG1486	melibiose metabolic process
BK011_10305	COG0277	FAD linked oxidase domain protein
BK011_10340	COG2081	HI0933 family
BK011_10370	COG0504	CTP synthase activity
BK011_10390	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BK011_10395	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BK011_10400	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BK011_10405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BK011_10410	COG1285	pathogenesis
BK011_10415	COG0037	tRNA processing
BK011_10420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BK011_10425	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BK011_10440	COG0737	Belongs to the 5'-nucleotidase family
BK011_10440	COG1525	nuclease
BK011_10440	COG4085	toxin activity
BK011_10460	COG3842	ATPase activity
BK011_10465	COG0017	Asparaginyl-tRNA synthetase
BK011_10485	COG0706	membrane insertase activity
BK011_10490	COG0594	ribonuclease P activity