locus-tag	class	description
HF295_00020	ENOG4106M28	alanine racemase domain protein
HF295_00030	ENOG4105EQ5	D-Lysine 5,6-aminomutase alpha subunit
HF295_00035	ENOG4105KIJ	D-ornithine aminomutase S component
HF295_00040	ENOG4107RH1	pyridoxal-5'-phosphate-dependent protein beta subunit
HF295_00045	ENOG4105Z5Q	
HF295_00050	ENOG4108KR4	dihydrodipicolinate reductase
HF295_00055	ENOG4105C5B	carbamate kinase
HF295_00060	ENOG4105DBV	ornithine carbamoyltransferase
HF295_00070	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HF295_00085	ENOG4105VYW	UPF0251 protein
HF295_00095	ENOG4105D3R	alkyl hydroperoxide reductase
HF295_00110	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HF295_00115	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HF295_00120	ENOG4105ETE	Transcriptional regulator (LacI family
HF295_00135	ENOG4105C59	p-type ATPase
HF295_00140	ENOG4107QSE	Dipeptidase
HF295_00145	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HF295_00160	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HF295_00170	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HF295_00175	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HF295_00190	ENOG4105C22	threonyL-tRNA synthetase
HF295_00200	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HF295_00205	ENOG4105ZAD	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HF295_00210	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HF295_00225	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HF295_00230	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HF295_00240	ENOG4108RAC	Rubrerythrin
HF295_00245	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HF295_00250	ENOG4105DJV	ribulose-phosphate 3-epimerase
HF295_00260	ENOG4105C0H	protease
HF295_00265	ENOG4105C0H	protease
HF295_00270	ENOG4105KME	endoribonuclease L-psp
HF295_00280	ENOG4105DP4	dak2 domain fusion protein ylov
HF295_00285	ENOG4105CB5	ATP-dependent DNA helicase recG
HF295_00290	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HF295_00305	ENOG4105CSM	endonuclease III
HF295_00315	ENOG4105D1F	ATP-binding protein
HF295_00325	ENOG41067VY	50S ribosomal protein L32
HF295_00330	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HF295_00510	ENOG4105DQ6	Transposase
HF295_00515	ENOG4105E4P	ATPase (AAA
HF295_00530	ENOG4105D8X	mechanosensitive ion channel
HF295_00535	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HF295_00540	ENOG4105D60	lipoprotein releasing system transmembrane protein
HF295_00550	ENOG4105C5S	asparaginyl-tRNA synthetase
HF295_00555	ENOG4105D3G	Pseudouridine synthase
HF295_00560	ENOG4105CKN	UDP-glucose-hexose-1-phosphate uridylyltransferase
HF295_00565	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HF295_00580	ENOG4105EPR	degv family
HF295_00585	ENOG4105BZ1	(ABC) transporter
HF295_00590	ENOG4105BZ1	(ABC) transporter
HF295_00605	ENOG4105BZ1	(ABC) transporter
HF295_00610	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HF295_00640	ENOG4105KRI	phosphocarrier protein (HPr
HF295_00650	ENOG4105C31	Tryptophanyl-tRNA synthetase
HF295_00655	ENOG4105DPN	Oligoendopeptidase f
HF295_00660	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
HF295_00675	ENOG4107RAQ	aminopeptidase
HF295_00680	ENOG4105C7H	Helicase, RecD TraA family
HF295_00685	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HF295_00690	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HF295_00695	ENOG4105VPH	UPF0473 protein
HF295_00710	ENOG4105CFP	Peptidase U32
HF295_00715	ENOG4107YHV	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HF295_00720	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HF295_00730	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
HF295_00735	ENOG4105CQW	ribosome biogenesis GTPase YqeH
HF295_00740	ENOG4108WF2	Metal Dependent Phosphohydrolase
HF295_00745	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HF295_00750	ENOG4105DXX	methyltransferase
HF295_00755	ENOG4105KQC	Competence protein
HF295_00760	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
HF295_00780	ENOG4105CA9	Pyruvate kinase
HF295_00800	ENOG4105C5H	ABC transporter
HF295_00805	ENOG4105C75	arginyL-tRNA synthetase
HF295_00810	ENOG4105BZ1	(ABC) transporter
HF295_00815	ENOG4105BZ1	(ABC) transporter
HF295_00820	ENOG4105EFZ	amidohydrolase
HF295_00845	ENOG4105WD1	Membrane
HF295_00850	ENOG4105C3M	thioredoxin reductase
HF295_00860	ENOG4105C26	Dehydrogenase
HF295_00900	ENOG4105CEY	Amp-dependent synthetase and ligase
HF295_00915	ENOG41083NF	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HF295_00930	ENOG4105C7W	Xanthine dehydrogenase
HF295_00940	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
HF295_00950	ENOG4105CD3	dihydroorotase
HF295_00955	ENOG4107UUR	Chlorohydrolase aminohydrolase
HF295_00960	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
HF295_00980	ENOG4105CPN	adenine deaminase
HF295_00995	ENOG4107S4Y	M20 DapE family protein YgeY
HF295_01000	ENOG4105IW6	Carbamoyltransferase
HF295_01010	ENOG4107Y2X	deaminase
HF295_01025	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HF295_01030	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HF295_01035	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HF295_01040	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HF295_01055	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HF295_01060	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HF295_01065	ENOG4107R37	Glutamate dehydrogenase
HF295_01080	ENOG4108JQ1	Dehydrogenase
HF295_01085	ENOG41087P5	50S ribosomal protein L33
HF295_01095	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HF295_01100	ENOG4105CV8	reductase
HF295_01115	ENOG4105E08	Glycoside hydrolase, family 9
HF295_01130	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HF295_01135	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
HF295_01155	ENOG4105DRS	transport system, permease
HF295_01165	ENOG4105ETE	Transcriptional regulator (LacI family
HF295_01175	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
HF295_01225	ENOG4105C2J	ABC transporter
HF295_01230	ENOG4105CNN	ABC, transporter
HF295_01235	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HF295_01240	ENOG41082SB	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HF295_01245	ENOG4105CFG	Acts as a chaperone (By similarity)
HF295_01250	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HF295_01280	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HF295_01295	ENOG4105C9A	Phoh family
HF295_01300	ENOG41080V7	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HF295_01305	ENOG4105KG3	cytidine deaminase
HF295_01310	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HF295_01320	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HF295_01325	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HF295_01330	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HF295_01335	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HF295_01350	ENOG4105EPR	degv family
HF295_01355	ENOG410834F	Transcriptional regulator
HF295_01365	ENOG410853A	UPF0154 protein
HF295_01370	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HF295_01375	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HF295_01395	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HF295_01400	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HF295_01405	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HF295_01410	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HF295_01420	ENOG4105CUT	histidyl-tRNA synthetase
HF295_01425	ENOG4105C02	permease
HF295_01435	ENOG4105CUZ	uba thif-type nad fad binding protein
HF295_01440	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HF295_01445	ENOG4107YWA	deoxycytidylate deaminase
HF295_01450	ENOG41063PX	domain protein
HF295_01475	ENOG4107TEJ	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HF295_01480	ENOG4105C34	Pseudouridine synthase
HF295_01485	ENOG4107FSS	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HF295_01490	ENOG4105C98	muts2 protein
HF295_01495	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HF295_01500	ENOG4105DTN	riboflavin biosynthesis protein ribF
HF295_01510	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HF295_01515	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HF295_01535	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HF295_01540	ENOG4107QUF	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HF295_01550	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HF295_01555	ENOG4105CSA	Coproporphyrinogen iii oxidase
HF295_01560	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HF295_01565	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
HF295_01580	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HF295_01585	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HF295_01595	ENOG4108VPX	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity)
HF295_01600	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HF295_01605	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HF295_01610	ENOG4105CJW	magnesium transporter
HF295_01615	ENOG4105CJW	magnesium transporter
HF295_01625	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HF295_01635	ENOG4105DFA	alanine racemase domain protein
HF295_01640	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
HF295_01650	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HF295_01680	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HF295_01695	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HF295_01700	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HF295_01705	ENOG4105W5Q	DNA repair protein (RadC
HF295_01740	ENOG41082AV	single-stranded DNA-binding protein
HF295_01745	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HF295_01750	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
HF295_01755	ENOG4105E9Q	Acyl-transferase
HF295_01760	ENOG4105FGV	Chromate
HF295_01785	ENOG4105C0H	protease
HF295_01800	ENOG4105CGH	5'-nucleotidase
HF295_01805	ENOG4105BZU	Histidine kinase
HF295_01810	ENOG4108TGR	phosphatase
HF295_01825	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HF295_01835	ENOG4105C5F	glutamine synthetase
HF295_01850	ENOG4105BZU	Histidine kinase
HF295_01855	ENOG4107QJZ	Glycosyl transferase, family 2
HF295_01865	ENOG4105D1H	recombination factor protein RarA
HF295_01875	ENOG4105HDK	L-asparaginase
HF295_01880	ENOG410852I	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HF295_01885	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HF295_01900	ENOG4105K46	50S ribosomal protein l27
HF295_01905	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HF295_01915	ENOG4105C59	p-type ATPase
HF295_01920	ENOG4108IUM	Glycogen debranching enzyme
HF295_01925	ENOG4105CG3	alpha amylase, catalytic region
HF295_01930	ENOG4105EG2	ABC transporter, permease
HF295_01945	ENOG4105CG3	alpha amylase, catalytic region
HF295_01965	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HF295_01970	ENOG4106H78	methyltransferase
HF295_01980	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HF295_01990	ENOG4108IUW	ABC transporter
HF295_02000	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HF295_02005	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HF295_02015	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HF295_02045	ENOG4108SDH	ABC, transporter
HF295_02050	ENOG4108IUW	ABC transporter
HF295_02055	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HF295_02060	ENOG4105VJV	50s ribosomal protein L35
HF295_02070	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HF295_02075	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HF295_02080	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HF295_02110	ENOG4105C59	p-type ATPase
HF295_02115	ENOG4105BZU	Histidine kinase
HF295_02120	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HF295_02140	ENOG4105DQ6	Transposase
HF295_02155	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HF295_02165	ENOG4108521	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HF295_02170	ENOG4105DER	m42 family
HF295_02175	ENOG4105EMS	pseudouridine synthase
HF295_02180	ENOG4105EVI	UPF0374 protein
HF295_02205	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HF295_02215	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HF295_02220	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HF295_02225	ENOG4107Y1F	Involved in the transcription termination process (By similarity)
HF295_02240	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HF295_02245	ENOG4107ZYR	domain protein
HF295_02255	ENOG4105BZU	Histidine kinase
HF295_02260	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HF295_02265	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HF295_02270	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HF295_02275	ENOG4105E2Z	phosphate ABC transporter (Permease
HF295_02280	ENOG4105C8U	phosphate abc transporter
HF295_02290	ENOG4105K70	DNA-binding protein
HF295_02305	ENOG4105CAT	Cytidine monophosphate kinase
HF295_02310	ENOG4105FE9	pseudouridine synthase
HF295_02320	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HF295_02330	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HF295_02340	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HF295_02350	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HF295_02355	ENOG4105D48	metallophosphoesterase
HF295_02365	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
HF295_02370	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HF295_02375	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HF295_02380	ENOG4105CDY	transcriptional regulatory protein
HF295_02385	ENOG4105QNR	S1 RNA binding domain protein
HF295_02395	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HF295_02420	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HF295_02440	ENOG4105C6T	cysteine synthase
HF295_02445	ENOG4105D7W	serine acetyltransferase
HF295_02455	ENOG4107QI6	Cysteine desulfurase
HF295_02465	ENOG4107QN2	dihydrolipoyl dehydrogenase
HF295_02485	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HF295_02535	ENOG4108ZMX	Domain of unknown function (DU1801)
HF295_02555	ENOG4105EPR	degv family
HF295_02585	ENOG4105DQ6	Transposase
HF295_02590	ENOG4105DQ6	Transposase
HF295_02665	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HF295_02695	ENOG4107XU6	Glycosyl transferase (Group 1
HF295_02710	ENOG4108IAJ	Nad-dependent epimerase dehydratase
HF295_02720	ENOG4105K64	Glycosyl transferase, family 2
HF295_02730	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HF295_02860	ENOG4108K8S	endonuclease I
HF295_02920	ENOG4105DBI	uridine monophosphokinase
HF295_02925	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
HF295_02940	ENOG4105E0A	ABC, transporter
HF295_02955	ENOG4105D64	Mechanosensitive ion channel
HF295_02965	ENOG4105C5H	ABC transporter
HF295_02980	ENOG4107QSA	Oxaloacetate decarboxylase
HF295_02990	ENOG4108JIK	carboxylase
HF295_02995	ENOG4105D9Q	decarboxylase (Beta subunit)
HF295_03020	ENOG4105FDK	ABC transporter
HF295_03025	ENOG4105DSE	periplasmic solute binding protein
HF295_03055	ENOG4108HW3	(ABC) transporter
HF295_03065	ENOG4105CDA	abc transporter atp-binding protein
HF295_03080	ENOG4105BZU	Histidine kinase
HF295_03090	ENOG4105CKM	Branched-chain carboxylic acid kinase
HF295_03095	ENOG4107RE7	phosphate butyryltransferase
HF295_03115	ENOG4105WGB	oxidoreductase, delta subunit
HF295_03125	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HF295_03130	ENOG4108K8S	endonuclease I
HF295_03145	ENOG4106CC8	Bacterial inner membrane protein
HF295_03155	ENOG4105C7N	Xanthine uracil vitamin C permease
HF295_03165	ENOG410815Q	OsmC family
HF295_03170	ENOG4105C26	Dehydrogenase
HF295_03210	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
HF295_03215	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HF295_03220	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HF295_03225	ENOG4105UQX	Mate efflux family protein
HF295_03240	ENOG4105CTQ	phosphohexokinase
HF295_03250	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HF295_03255	ENOG4105CPQ	Dehydrogenase
HF295_03270	ENOG4108U5N	UPF0316 protein
HF295_03275	ENOG4105E0M	Sulfatase
HF295_03280	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HF295_03285	ENOG4108Z0R	Transferase
HF295_03290	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HF295_03295	ENOG4105DMC	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3
HF295_03310	ENOG4108JQ7	(ABC) transporter
HF295_03325	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HF295_03330	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HF295_03345	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HF295_03355	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HF295_03365	ENOG41090A1	ferritin
HF295_03400	ENOG4105DAP	Nicotinate phosphoribosyltransferase
HF295_03415	ENOG4108UT2	hemolysin iii
HF295_03425	ENOG4108YZG	isomerase
HF295_03435	ENOG4105CDA	abc transporter atp-binding protein
HF295_03440	ENOG4105EAD	ABC transporter
HF295_03445	ENOG4106PMH	Extracellular solute-binding protein family 3
HF295_03450	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HF295_03465	ENOG4105C5F	glutamine synthetase
HF295_03495	ENOG4105CBX	hi0933 family
HF295_03500	ENOG4108UH6	UPF0754 membrane protein
HF295_03505	ENOG4105CGK	Exodeoxyribonuclease III
HF295_03540	ENOG4108WVK	Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity)
HF295_03590	ENOG4108WVK	Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity)
HF295_03600	ENOG4105DQ6	Transposase
HF295_03620	ENOG4105Y5S	NADH ubiquinone oxidoreductase, 24 kD
HF295_03630	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
HF295_03635	ENOG4105CMU	LysR family (Transcriptional regulator
HF295_03640	ENOG4105C10	Electron transfer flavoprotein
HF295_03645	ENOG4105BZJ	Electron transfer flavoprotein
HF295_03650	ENOG4105C1G	acyl-Coa dehydrogenase
HF295_03660	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HF295_03665	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HF295_03685	ENOG4106AKJ	
HF295_03700	ENOG4105C59	p-type ATPase
HF295_03715	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HF295_03720	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HF295_03730	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HF295_03740	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HF295_03755	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HF295_03770	ENOG4108DBC	nitroreductase
HF295_03785	ENOG4108SAX	Membrane
HF295_03800	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HF295_03805	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HF295_03820	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
HF295_03830	ENOG4105MS2	ribosomal subunit Interface protein
HF295_03845	ENOG4105C8T	Leucyl-tRNA synthetase
HF295_03855	ENOG4105N5T	Radical SAM Protein
HF295_03860	ENOG4105SX7	Transporter
HF295_03885	ENOG4108W5N	phosphatidylglycerophosphatase a
HF295_03890	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HF295_03895	ENOG4105C25	Primosomal protein n'
HF295_03900	ENOG4105CN5	Metallo-Beta-Lactamase
HF295_03910	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HF295_03915	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HF295_03920	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HF295_03930	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
HF295_03935	ENOG4105CHV	Transcription elongation factor NusA
HF295_03940	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HF295_03950	ENOG4108RWN	rrna methyltransferase
HF295_03970	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
HF295_03975	ENOG4108ZGC	gaf domain protein
HF295_03980	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HF295_03985	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HF295_03990	ENOG4105CP7	Triose-phosphate isomerase
HF295_03995	ENOG4105BZA	Phosphoglycerate kinase
HF295_04005	ENOG4105X0R	protein from nitrogen regulatory protein P-II
HF295_04020	ENOG4105DIW	FeS assembly protein SUFB
HF295_04025	ENOG4108UNV	SUF system FeS assembly protein, NifU family
HF295_04030	ENOG4105C9B	Cysteine desulfurase
HF295_04040	ENOG4105C3K	feS assembly ATPase SufC
HF295_04045	ENOG4105KT7	mgtC SapB transporter
HF295_04065	ENOG4105Q2H	domain protein
HF295_04110	ENOG41081E8	Alpha beta hydrolase
HF295_04115	ENOG4107RCM	Releases the N-terminal proline from various substrates (By similarity)
HF295_04120	ENOG4105CYC	Transferase
HF295_04130	ENOG4108IV0	ABC, transporter
HF295_04135	ENOG4105C0Z	ABC transporter
HF295_04140	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
HF295_04150	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HF295_04155	ENOG4105CHR	reductase
HF295_04160	ENOG4105CHU	acetyl-coa acetyltransferase
HF295_04165	ENOG4105PF9	Transcriptional regulator
HF295_04200	ENOG4108IUM	Glycogen debranching enzyme
HF295_04205	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HF295_04210	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HF295_04245	ENOG4105EPR	degv family
HF295_04260	ENOG4105VB6	UPF0109 protein
HF295_04265	ENOG4105K5M	30s ribosomal protein S16
HF295_04275	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HF295_04280	ENOG4105CNW	domain protein
HF295_04290	ENOG4105CTZ	aminopeptidase c
HF295_04300	ENOG4105CTZ	aminopeptidase c
HF295_04305	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
HF295_04310	ENOG4105BZ8	glutamate synthase
HF295_04340	ENOG4105C87	Aminotransferase class I and II
HF295_04345	ENOG4105BZU	Histidine kinase
HF295_04350	ENOG4105D7N	magnesium and cobalt transport protein CorA
HF295_04360	ENOG410841Q	phosphoesterase PA-phosphatase related protein
HF295_04400	ENOG4105E4P	ATPase (AAA
HF295_04420	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HF295_04440	ENOG4107R3N	Filamentation induced by cAMP protein fic
HF295_04625	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HF295_04630	ENOG4105C79	DNA protecting protein DprA
HF295_04650	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HF295_04700	ENOG4105PNS	DnaD domain protein
HF295_04715	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HF295_04760	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
HF295_04770	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HF295_04780	ENOG4105CEM	UPF0597 protein
HF295_04785	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
HF295_04790	ENOG4107RUY	(E1 component), alpha subunit
HF295_04795	ENOG4105CPP	Dehydrogenase, E1 component
HF295_04800	ENOG4105C7S	Dehydrogenase
HF295_04805	ENOG4107QN2	dihydrolipoyl dehydrogenase
HF295_04810	ENOG4105DF9	Lipoate-protein, ligase
HF295_04820	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HF295_04825	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HF295_04830	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HF295_04855	ENOG4105KJM	monovalent cation h antiporter subunit g
HF295_04865	ENOG4105SC1	monovalent cation H antiporter subunit E
HF295_04885	ENOG4105D1Q	UPF0246 protein
HF295_04890	ENOG4105E0M	Sulfatase
HF295_04895	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HF295_04915	ENOG4105BZU	Histidine kinase
HF295_04940	ENOG4105BZU	Histidine kinase
HF295_04955	ENOG4105E4P	ATPase (AAA
HF295_04985	ENOG4105DZP	Membrane-associated zinc metalloprotease
HF295_04990	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HF295_04995	ENOG4105KNE	Phosphatidate cytidylyltransferase
HF295_05005	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HF295_05010	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HF295_05015	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HF295_05020	ENOG4105CE9	30S ribosomal protein S2
HF295_05025	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HF295_05030	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HF295_05035	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HF295_05040	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HF295_05045	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HF295_05050	ENOG4106F7A	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HF295_05055	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
HF295_05060	ENOG4105VH4	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HF295_05065	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
HF295_05080	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HF295_05085	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HF295_05090	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HF295_05095	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HF295_05115	ENOG4108KP7	hydrolase
HF295_05130	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HF295_05135	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HF295_05140	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HF295_05145	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HF295_05150	ENOG4105CDU	Replicative dna helicase
HF295_05155	ENOG4105BZR	domain protein
HF295_05160	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HF295_05165	ENOG4108UUM	single-stranded DNA-binding protein
HF295_05170	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HF295_05185	ENOG4105CEV	competence damage-inducible protein
HF295_05190	ENOG4105C3G	gtp-binding protein
HF295_05195	ENOG4105F8V	Hydrolase, tatD family
HF295_05200	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HF295_05205	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HF295_05210	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HF295_05215	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HF295_05220	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HF295_05225	ENOG4105M6F	mutator MutT protein
HF295_05235	ENOG4105CH6	catalase
HF295_05240	ENOG4105WD1	Membrane
HF295_05250	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HF295_05300	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HF295_05305	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HF295_05310	ENOG4107Y49	methyltransferase
HF295_05315	ENOG41082SK	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HF295_05325	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HF295_05330	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HF295_05335	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HF295_05340	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HF295_05345	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HF295_05365	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HF295_05370	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HF295_05375	ENOG4105C8N	cysteinyl-tRNA synthetase
HF295_05380	ENOG4105VEQ	Cold shock protein
HF295_05390	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HF295_05395	ENOG4105KWI	UPF0339 protein
HF295_05400	ENOG4108UJD	30S ribosomal protein S9
HF295_05405	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HF295_05415	ENOG4108Z0Z	intracellular protease Pfpi family
HF295_05420	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HF295_05425	ENOG41060K3	Methyltransferase
HF295_05430	ENOG4105MA4	psp1 domain protein
HF295_05435	ENOG4105FA2	dna polymerase iii
HF295_05440	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HF295_05445	ENOG4105FDK	ABC transporter
HF295_05450	ENOG4105FAV	ABC, transporter
HF295_05455	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HF295_05460	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
HF295_05465	ENOG4108JJB	ABC transporter
HF295_05470	ENOG4108JJB	ABC transporter
HF295_05480	ENOG4108ZT0	50S ribosomal protein l17
HF295_05485	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HF295_05490	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HF295_05495	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HF295_05500	ENOG41067V7	50S ribosomal protein L36
HF295_05505	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HF295_05510	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HF295_05515	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HF295_05520	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HF295_05530	ENOG4105VPB	50S ribosomal protein L30
HF295_05540	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HF295_05545	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HF295_05550	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HF295_05555	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HF295_05565	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HF295_05570	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HF295_05580	ENOG41082SA	50s ribosomal protein l29
HF295_05590	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HF295_05595	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HF295_05600	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HF295_05605	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HF295_05610	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HF295_05615	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HF295_05620	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HF295_05625	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HF295_05630	ENOG4105DVT	helicase
HF295_05645	ENOG4105WKZ	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
HF295_05655	ENOG4107SFZ	crispr-associated protein
HF295_05660	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
HF295_05665	ENOG4107QW4	alcohol dehydrogenase
HF295_05670	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HF295_05675	ENOG4105ECY	inositol monophosphatase
HF295_05715	ENOG4107XJU	UPF0178 protein
HF295_05745	ENOG4105BZU	Histidine kinase
HF295_05815	ENOG4105FA0	parb-like partition protein
HF295_05820	ENOG4107QJE	Chromosome Partitioning Protein
HF295_05835	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HF295_05840	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HF295_05845	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HF295_05860	ENOG4108Z6B	deaminase
HF295_05865	ENOG4107104	thymidine kinase
HF295_05870	ENOG41082DI	50s ribosomal protein l31
HF295_05875	ENOG4105C6K	Malic enzyme
HF295_05880	ENOG4108Z03	MAF-like protein
HF295_05885	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HF295_05890	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HF295_05895	ENOG41082I2	s4 domain protein
HF295_05905	ENOG4105CRK	lysyL-tRNA synthetase
HF295_05925	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HF295_05930	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HF295_05935	ENOG4105CTD	carboxy-peptidase
HF295_05950	ENOG4105EAM	Na Pi-cotransporter
HF295_05955	ENOG4105SFS	phosphoesterase RecJ domain protein
HF295_05960	ENOG4105SFS	phosphoesterase RecJ domain protein
HF295_05965	ENOG4108K8S	endonuclease I
HF295_05985	ENOG4105DR3	abc transporter permease protein
HF295_05990	ENOG4107Z33	ABC transporter, permease
HF295_05995	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HF295_06020	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HF295_06025	ENOG4105C6E	dna polymerase iii
HF295_06035	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HF295_06040	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HF295_06065	ENOG4105C5S	asparaginyl-tRNA synthetase
HF295_06085	ENOG4105K4W	Could be involved in septation (By similarity)
HF295_06090	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HF295_06100	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HF295_06105	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HF295_06110	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HF295_06115	ENOG4105D49	3-dehydroquinate synthase
HF295_06120	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HF295_06130	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HF295_06135	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
HF295_06200	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HF295_06205	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HF295_06210	ENOG4105VG0	50S ribosomal protein l34
HF295_06215	ENOG4108585	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HF295_06235	ENOG4105K59	histidine triad (HIT) protein
HF295_06240	ENOG4107XGZ	Hydrolase
HF295_06245	ENOG4105CBD	Diacylglycerol kinase
HF295_06250	ENOG4105HVR	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity)
HF295_06255	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HF295_06260	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HF295_06265	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HF295_06270	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HF295_06275	ENOG4105CPI	Metal Dependent Phosphohydrolase
HF295_06300	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HF295_06315	ENOG4105IHM	Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity)
HF295_06320	ENOG4105C8B	TIGR00159 family
HF295_06335	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HF295_06340	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HF295_06350	ENOG41083MR	nifu domain-containing protein
HF295_06365	ENOG4107QYV	phosphohexose isomerase
HF295_06375	ENOG4105K8N	protein family UPF0079, ATPase
HF295_06380	ENOG41072GX	Peptidase M22 Glycoprotease
HF295_06390	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HF295_06410	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HF295_06425	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
HF295_06430	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HF295_06435	ENOG4105CIE	May be required for sporulation (By similarity)
HF295_06505	ENOG4107S21	permease
HF295_06520	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HF295_06525	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HF295_06530	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HF295_06535	ENOG410848D	S4 domain protein YaaA
HF295_06540	ENOG4108JA2	transcriptioN-repair coupling factor
HF295_06545	ENOG4108IXY	short-chain dehydrogenase reductase
HF295_06565	ENOG4108UYI	beta-alanyl-CoA ammonia lyase
HF295_06570	ENOG4105DE9	3-keto-5-aminohexanoate cleavage enzyme
HF295_06575	ENOG4105FRY	Dehydrogenase
HF295_06580	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
HF295_06590	ENOG4105EQ5	D-Lysine 5,6-aminomutase alpha subunit
HF295_06595	ENOG4107CHF	5,6-aminomutase beta subunit
HF295_06600	ENOG4108WBT	adenosyltransferase
HF295_06605	ENOG4107YT1	Glutamate mutase subunit sigma
HF295_06625	ENOG4105XGS	Covalent carrier of the coenzyme of citrate lyase (By similarity)
HF295_06635	ENOG4105CHY	citrate lyase, alpha
HF295_06655	ENOG4107QJQ	Mate efflux family protein
HF295_06730	ENOG4107WUB	V-type ATPase 116 kDa subunit
HF295_06750	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
HF295_06755	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
HF295_06760	ENOG4106C6A	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HF295_06780	ENOG4105DFM	M18 family aminopeptidase
HF295_06790	ENOG4105PAD	Hydrolase
HF295_06795	ENOG4105HFT	AraC family transcriptional regulator
HF295_06805	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
HF295_06815	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HF295_06825	ENOG4105EPR	degv family
HF295_06830	ENOG4108UW5	maltose o-acetyltransferase
HF295_06855	ENOG4105DQ6	Transposase
HF295_06920	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HF295_06925	ENOG4108K8S	endonuclease I
HF295_06935	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HF295_06940	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HF295_06950	ENOG4105C0B	DNA polymerase III (alpha subunit)
HF295_06985	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HF295_07020	ENOG4105C59	p-type ATPase
HF295_07075	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HF295_07085	ENOG4105CNN	ABC, transporter
HF295_07090	ENOG4108RVA	ribokinase
HF295_07095	ENOG410804X	Transcriptional regulator
HF295_07100	ENOG4105UP7	3-epimerase
HF295_07110	ENOG4108YZG	isomerase
HF295_07150	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
HF295_07155	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HF295_07160	ENOG41075D4	Aminoglycoside 6-adenylyltransferase
HF295_07185	ENOG410749K	Uncharacterized protein conserved in bacteria (DUF2179)
HF295_07195	ENOG4107R7I	amino acid
HF295_07200	ENOG4105CVR	type I restriction-modification system
HF295_07205	ENOG4105EKX	Restriction modification system DNA (Specificity
HF295_07210	ENOG4105DZR	Type I site-specific deoxyribonuclease
HF295_07235	ENOG4108HED	Type II restriction
HF295_07330	ENOG4105DD7	kinase (PfkB family
HF295_07340	ENOG4108Z0Z	intracellular protease Pfpi family
HF295_07375	ENOG4105C1J	atp-dependent rna helicase
HF295_07390	ENOG4105EJV	Membrane
HF295_07395	ENOG4108MTT	Glutamate-rich protein grpB
HF295_07410	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
HF295_07415	ENOG4107SVH	Potassium channel protein
HF295_07425	ENOG4105DP4	dak2 domain fusion protein ylov
HF295_07430	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HF295_07440	ENOG4105C0F	tryptophanase EC 4.1.99.1
HF295_07485	ENOG4105MAX	Superoxide reductase
HF295_07490	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HF295_07495	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HF295_07515	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HF295_07520	ENOG4105BZU	Histidine kinase
HF295_07530	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HF295_07550	ENOG4107QI1	Mate efflux family protein
HF295_07555	ENOG4105BZ1	(ABC) transporter
HF295_07575	ENOG4105KST	dependent repressor
HF295_07580	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
HF295_07585	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HF295_07590	ENOG4105CG3	alpha amylase, catalytic region
HF295_07660	ENOG4105KNA	-acetyltransferase
HF295_07675	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
HF295_07685	ENOG4105DVE	abc transporter atp-binding protein
HF295_07725	ENOG4105C9K	Endothelin-converting enzyme 1
HF295_07740	ENOG4105BZU	Histidine kinase
HF295_07745	ENOG4105BZU	Histidine kinase
HF295_07765	ENOG4105FE9	pseudouridine synthase
HF295_07770	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HF295_07790	ENOG4105UIB	(ABC) transporter
HF295_07795	ENOG4108JQ9	ABC transporter
HF295_07800	ENOG4107TFB	basic membrane
HF295_07830	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HF295_07840	ENOG4105D6A	Electron transport complex
HF295_07845	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HF295_07895	ENOG4108FN7	Aldo keto reductase
HF295_07930	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HF295_07935	ENOG4105C83	adenylosuccinate lyase
HF295_07940	ENOG4107ZXI	Rhomboid family
HF295_07945	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HF295_07950	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HF295_07955	ENOG4105CHR	reductase
HF295_07960	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HF295_07970	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HF295_07975	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HF295_07980	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HF295_07985	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HF295_07990	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HF295_08035	ENOG4105F38	ABC transporter, permease
HF295_08055	ENOG4108Z5K	methylglyoxal synthase
HF295_08065	ENOG4108RVA	ribokinase
HF295_08080	ENOG4105CHM	Aminotransferase
HF295_08085	ENOG4107ZE5	PPIases accelerate the folding of proteins
HF295_08090	ENOG4108SA1	esterase
HF295_08105	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HF295_08110	ENOG4107VWA	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity)
HF295_08115	ENOG4105JAB	phenazine biosynthesis protein, phzf family
HF295_08120	ENOG4105Y3U	Transglycosylase-associated protein
HF295_08125	ENOG410630P	Transcriptional regulator
HF295_08135	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HF295_08175	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
HF295_08180	ENOG4105EJQ	L-serine dehydratase
HF295_08190	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
HF295_08195	ENOG4107QIZ	NADH dehydrogenase
HF295_08200	ENOG4107QHI	-hydrogenase
HF295_08220	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HF295_08225	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HF295_08245	ENOG4105E4P	ATPase (AAA
HF295_08255	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HF295_08275	ENOG4108JU3	Alkyl hydroperoxide reductase
HF295_08280	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HF295_08285	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
HF295_08325	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HF295_08345	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HF295_08355	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HF295_08360	ENOG4105CEN	a g-specific adenine glycosylase
HF295_08365	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HF295_08400	ENOG4105FBA	Phospholipase Carboxylesterase
HF295_08410	ENOG4105CJ1	ABC, transporter
HF295_08420	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HF295_08425	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HF295_08450	ENOG4108K8S	endonuclease I
HF295_08465	ENOG4105DG4	malate L-lactate dehydrogenase
HF295_08490	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HF295_08500	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HF295_08530	ENOG4105CZN	Potassium uptake protein
HF295_08535	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HF295_08545	ENOG4105K63	Thioredoxin
HF295_08550	ENOG4105C3M	thioredoxin reductase
HF295_08570	ENOG4105CI3	gtp-binding protein typa
HF295_08575	ENOG4105CIG	ABC transporter
HF295_08590	ENOG4105CXN	decarboxylase
HF295_08605	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
HF295_08610	ENOG4105D6A	Electron transport complex
HF295_08625	ENOG4105DZB	Electron transport complex
HF295_08630	ENOG4105DGN	Electron transport complex
HF295_08645	ENOG4105C84	Histidine ammonia-lyase
HF295_08650	ENOG4105CGP	Urocanate hydratase
HF295_08655	ENOG4105CCS	Glutamate formiminotransferase
HF295_08660	ENOG4105CI2	imidazolone-5-propionate hydrolase
HF295_08665	ENOG410908R	Methenyltetrahydrofolate cyclohydrolase
HF295_08670	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HF295_08685	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HF295_08695	ENOG4105E1F	short-chain dehydrogenase reductase
HF295_08705	ENOG4108V06	Glutathione peroxidase